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https://www.readbyqxmd.com/read/27933751/synthesis-of-acetone-derived-c6-c9-and-c12-carbon-scaffolds-for-chemical-and-fuel-applications
#1
Cameron M Moore, Rhodri W Jenkins, Michael T Janicke, William L Kubic, Evgueni Polikarpov, Troy A Semelsberger, Andrew D Sutton
A simple, inexpensive catalyst system (Amberlyst 15 and Ni/SiO2 -Al2 O3 ) is described for the upgrading of acetone to a range of chemicals and potential fuels. Stepwise hydrodeoxygenation of the produced ketones can yield branched alcohols, alkenes, and alkanes. An analysis of these products is provided, which demonstrates that this approach can provide a product profile of valuable bioproducts and potential biofuels.
December 9, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27933725/cellular-engineering-for-therapeutic-protein-production-product-quality-host-modification-and-process-improvement
#2
REVIEW
Evan Wells, Anne Skaja Robinson
Recombinant proteins offer many therapeutic advantages unavailable in traditional small molecule drugs, but the need for cellular versus chemical synthesis complicates production. Avenues for producing therapeutic biologics are continuously expanding, and developments in biochemistry, cell biology, and bioengineering fuel new discoveries that promise safer, more efficient, and cheaper drugs for consumers. Numerous approaches to express recombinant proteins exist, but Escherichia coli, Saccharomyces cerevisiae, and mammalian systems (e...
December 9, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27933723/comfa-topomer-comfa-and-hqsar-studies-on-a-series-of-novel-hiv-1-protease-inhibitors
#3
Afsane Heidari, Mohammad H Fatemi
Comparative molecular field analysis (CoMFA), topomer CoMFA and hologram QSAR (HQSAR) as three efficient methods of QSAR have been performed on 40 newly synthesized inhibitors against HIV-1 protease. Molecular alignment was done by aid of crystallographic structure of template inhibitor (indirectly alignment) and also by the molecular mechanic (MM) minimized structure. Both alignment methods produced satisfactory statistics for training set, but indirectly alignment had more predictive power. Generated counter maps, especially by topomer CoMFA, give comprehensive information about structural features affecting the inhibitory activities of studied chemicals...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933719/depth-profiling-cross-linked-poly-methyl-methacrylate-films-a-tof-sims-approach
#4
Soheila Naderi-Gohar, Kevin M H Huang, Yiliang Wu, Woon Ming Lau, Heng-Yong Nie
RATIONALE: In order to determine the degree of cross-linking on the surface and its variations in a nanometer-scale depth of organic materials, we developed an approach based on time-of-flight secondary ion mass spectrometry (TOF-SIMS), which provides rich chemical information in the form of fragment ions. TOF-SIMS is extremely surface sensitive and capable of depth profiling with the use of a sputter ion beam to remove controllable amounts of substance. METHODS: Poly(methyl methacrylate) (PMMA) films spin-coated on a Si substrate were cross-linked using a recently developed, surface sensitive, hyperthermal hydrogen projectile bombardment technique...
December 9, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27933714/development-of-chemical-tools-to-monitor-and-control-isoaspartyl-peptide-methyltransferase-activity
#5
Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuteru Urano
We have established a coupled assay system targeting protein l-isoaspartyl methyltransferase (PIMT), a key enzyme in the metabolism of isoaspartyl peptides and proteins. The system utilizes a fluorogenic peptide probe containing an isoaspartyl residue at the P1' position of the caspase-3 recognition sequence. Following PIMT-catalyzed methyl transfer reaction, the methylated probe is specifically cleaved by caspase-3 to give fluorescence activation. High-throughput screening of our chemical library with this assay system identified PIMT inhibitors that may be useful as leads in the design of chemical probes for controlling PIMT activity...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933702/multiparameter-particle-display-mppd-a-quantitative-screening-method-for-the-discovery-of-highly-specific-aptamers
#6
Jinpeng Wang, Jingwen Yu, Qin Yang, John McDermott, Alexander Scott, Matthew Vukovich, Remy Lagrois, Qiang Gong, William Greenleaf, Michael Eisenstein, B Scott Ferguson, H Tom Soh
Aptamers are a promising class of affinity reagents because they are chemically synthesized, thus making them highly reproducible and distributable as sequence information rather than a physical entity. Although many high-quality aptamers have been previously reported, it is difficult to routinely generate aptamers that possess both high affinity and specificity. One of the reasons is that conventional aptamer selection can only be performed either for affinity (positive selection) or for specificity (negative selection), but not both simultaneously...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933699/room-temperature-arylation-of-thiols-breakthrough-with-aryl-chlorides
#7
Min Jiang, Haifang Li, Haijun Yang, Hua Fu
The formation of aryl C-S bonds is an important chemical transformation because aryl sulfides are valuable building blocks for the synthesis of biologically and pharmaceutically active molecules and organic materials. Aryl sulfides have traditionally been synthesized through the transition-metal-catalyzed cross-coupling of aryl halides with thiols. However, the aryl halides used are usually bromides and iodides; readily available, low-cost aryl chlorides often not reactive enough. Furthermore, the deactivation of transition-metal catalysts by thiols has forced chemists to use high catalyst loadings, specially designed ligands, high temperatures, and/or strong bases, thus leading to high costs and the incompatibility of some functional groups...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933684/enhancement-of-ag-based-plasmonic-photocatalysis-in-the-hydrogen-production-from-ammonia-borane-by-the-assist-of-single-site-ti-oxide-moiety-within-the-silica-framework
#8
Priyanka Verma, Yasutaka Kuwahara, Kohsuke Mori, Hiromi Yamashita
Ag nanoparticles (NPs) have gained great attention owing to their interesting plasmonic properties showing efficient catalysis under visible light irradiation. In this study, Ag-based plasmonic catalyst supported on the mesoporous silica involving isolated and tetrahedrally coordinated single-site Ti-oxide moieties, Ag/Ti-SBA-15, has been designed with the purpose of utilizing the broad spectrum range of solar energy. The Ti-SBA-15 support allows the deposition of small Ag NPs with a narrow size distribution...
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27933669/characterization-of-nitrated-sugar-alcohols-by-atmospheric-pressure-chemical-ionization-mass-spectrometry
#9
Alla Ostrinskaya, Jude A Kelley, Roderick R Kunz
RATIONALE: The nitrated sugar alcohols mannitol hexanitrate (MHN), sorbitol hexanitrate (SHN) and xylitol pentanitrate (XPN) are in the same class of compounds as the powerful military grade explosive pentaerythritol tetranitrate (PETN) and the homemade explosive erythritol tetranitrate (ETN) but, unlike for PETN and ETN, ways to detect MHN, SHN and XPN by mass spectrometry (MS) have not been fully investigated. METHODS: Atmospheric-pressure chemical-ionization mass spectrometry (APCI-MS) was used to detect ions characteristic of nitrated sugar alcohols...
December 9, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27933609/the-role-of-electrical-and-jasmonate-signalling-in-the-recognition-of-captured-prey-in-the-carnivorous-sundew-plant-drosera-capensis
#10
Miroslav Krausko, Zdeněk Perutka, Marek Šebela, Olga Šamajová, Jozef Šamaj, Ondřej Novák, Andrej Pavlovič
The carnivorous sundew plant (Drosera capensis) captures prey using sticky tentacles. We investigated the tentacle and trap reactions in response to the electrical and jasmonate signalling evoked by different stimuli to reveal how carnivorous sundews recognize digestible captured prey in their traps. We measured the electrical signals, phytohormone concentration, enzyme activities and Chla fluorescence in response to mechanical stimulation, wounding or insect feeding in local and systemic traps. Seven new proteins in the digestive fluid were identified using mass spectrometry...
December 9, 2016: New Phytologist
https://www.readbyqxmd.com/read/27933587/development-of-a-more-efficient-albumin-based-delivery-system-for-gambogic-acid-with-low-toxicity-for-lung-cancer-therapy
#11
Yan Zhang, Zhijie Yang, Xinyi Tan, Xing Tang, Zaixing Yang
Gambogic acid (GA) has been proven to be a potent chemotherapeutic agent for the treatment of lung cancer in clinical trials. However, GA is limited in its therapeutic value by properties such as poor water solubility and low chemical stability. In clinical trials, cationic arginine (Arg) was added to solubilize GA, and this may also cause other side effects. Here, we have designed and developed a more efficient human serum albumin (HSA)-based delivery system for GA with low toxicity which helps improve its solubility, chemical stability and increases its antitumor efficacy...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27933577/environmental-and-health-impacts-of-effluents-from-textile-industries-in-ethiopia-the-case-of-gelan-and-dukem-oromia-regional-state
#12
Diriba Dadi, Till Stellmacher, Feyera Senbeta, Steven Van Passel, Hossein Azadi
This study focuses on four textile industries (DH-GEDA, NOYA, ALMHADI, and ALSAR) established between 2005 and 2008 in the peri-urban areas of Dukem and Gelan. The objectives of the study were to generate baseline information regarding the concentration levels of selected pollutants and to analyze their effects on biophysical environments. This study also attempts to explore the level of exposure that humans and livestock have to polluted effluents and the effects thereof. The findings of this study are based on data empirically collected from two sources: laboratory analysis of sample effluents from the four selected textile plants and quantitative as well as qualitative socioeconomic data collection...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27933554/use-of-anticoagulant-rodenticides-by-pest-management-professionals-in-massachusetts-usa
#13
Kristin Memmott, Maureen Murray, Allen Rutberg
Secondary exposure to chemical rodenticides, specifically second-generation anticoagulant rodenticides (SGARs), poses a threat to non-target wildlife including birds of prey. Federal regulations in the United States currently limit homeowner access to SGARs as a way of minimizing this threat. With legal access to SGARs, pest management professionals (PMPs) represent a potential linkage to non-target exposure. There is limited research focused on rodent control practices, chemical rodenticide preferences, level of concern and awareness, or opinions on rodenticide regulations as they relate to PMPs...
December 8, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27933552/use-of-low-density-polyethylene-membranes-for-assessment-of-genotoxicity-of-pahs-in-the-seine-river
#14
Françoise Vincent-Hubert, Emmanuelle Uher, Carole Di Giorgio, Cécile Michel, Michel De Meo, Catherine Gourlay-France
The genotoxicity of river water dissolved contaminants is usually estimated after grab sampling of river water. Water contamination can now be obtained with passive samplers that allow a time-integrated sampling of contaminants. Since it was verified that low density polyethylene membranes (LDPE) accumulate labile hydrophobic compounds, their use was proposed as a passive sampler. This study was designed to test the applicability of passive sampling for combined chemical and genotoxicity measurements. The LDPE extracts were tested with the umu test (TA1535/pSK1002 ± S9) and the Ames assay (TA98, TA100 and YG1041 ± S9)...
December 8, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27933454/improved-production-of-adipate-with-escherichia-coli-by-reversal-of-%C3%AE-oxidation
#15
Nicolai Kallscheuer, Jochem Gätgens, Marvin Lübcke, Jörg Pietruszka, Michael Bott, Tino Polen
The linear C6 dicarboxylic acid adipic acid is an important bulk chemical in the petrochemical industry as precursor of the polymer nylon-6,6-polyamide. In recent years, efforts were made towards the biotechnological production of adipate from renewable carbon sources using microbial cells. One strategy is to produce adipate via a reversed β-oxidation pathway. Hitherto, the adipate titers were very low due to limiting enzyme activities for this pathway. In most cases, the CoA intermediates are non-natural substrates for the tested enzymes and were therefore barely converted...
December 8, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27933436/emerging-biotechnologies-for-production-of-itaconic-acid-and-its-applications-as-a-platform-chemical
#16
REVIEW
Badal C Saha
Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L(-1)) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L(-1)). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A...
December 8, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27933421/erratum-to-an-experimental-framework-for-generating-evolvable-chemical-systems-in-the-laboratory
#17
David A Baum, Kalin Vetsigian
No abstract text is available yet for this article.
December 8, 2016: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/27933420/comparative-simulation-study-of-chemical-synthesis-of-functional-dadne-material
#18
Min Hsien Liu, Chuan Wen Liu
Amorphous molecular simulation to model the reaction species in the synthesis of chemically inert and energetic 1,1-diamino-2,2-dinitroethene (DADNE) explosive material was performed in this work. Nitromethane was selected as the starting reactant to undergo halogenation, nitration, deprotonation, intermolecular condensation, and dehydration to produce the target DADNE product. The Materials Studio (MS) forcite program allowed fast energy calculations and reliable geometric optimization of all aqueous molecular reaction systems (0...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27933323/assessing-collagen-and-micro-permeability-at-the-proanthocyanidin-treated-resin-dentin-interface
#19
Berdan Aydin, Lina Saleh Hassan, Grace Viana, Ana K Bedran-Russo
PURPOSE: To establish a fluorescence-based method to simultaneously assess micro-permeability and collagen cross-linking induced by chemical agents at the resin-dentin interface. MATERIALS AND METHODS: Three chemical agents were investigated (proanthocyanidin-rich grape seed extract: GSE; carbodiimide hydrochloride/N-hydroxysuccinimide: EDC/NHS; glutaraldehyde: GD) along with a control (distilled water) as primers applied on flat occlusal dentin surfaces of 48 teeth and restored with two commercially available etch-and-rinse adhesives...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27933257/assessment-of-the-quality-of-groundwater-for-drinking-purposes-in-the-upper-west-and-northern-regions-of-ghana
#20
Sixtus Bieranye Bayaa Martin Saana, Samuel Asiedu Fosu, Godfred Etsey Sebiawu, Napoleon Jackson, Thomas Karikari
BACKGROUND: Underground water is an important natural resource serving as a reliable source of drinking water for many people worldwide, especially in developing countries. Underground water quality needs to be given a primary research and quality control attention due to possible contamination. This study was therefore designed to determine the physico-chemical and bacteriological quality of borehole water in the Upper West and Northern regions of Ghana. METHODS: The study was conducted in seven districts in Ghana (including six in the Upper West region and one in the Northern region)...
2016: SpringerPlus
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