Hongming Tang, Tao Hou, Han Zhou, Han Liao, Fangfang Xu, Xiaomin Xie, Wenjie Yuan, Zhixin Guo, Yanfang Liu, Jixia Wang, Weijia Zhou, Xinmiao Liang
Histamine 4 receptor (H4R), the most recently identified subtype of histamine receptor, primarily induces inflammatory reactions upon activation. Several H4R antagonists have been developed for the treatment of inflammatory bowel disease (IBD) and atopic dermatitis (AD), but their use has been limited by adverse side effects, such as a short half-life and toxicity. Natural products, as an important source of anti-inflammatory agents, offer minimal side effects and reduced toxicity. This work aimed to identify novel H4R antagonists from natural products...
April 18, 2024: Bioorganic Chemistry