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Zhongqiao Hu, Jianwen Jiang
A microscopic understanding of chiral separation mechanisms in liquid chromatography is significant in the pharmaceutical industry to facilitate the rational design of novel stationary phases and the optimization of separation processes. A molecular simulation study is reported to investigate the chiral separation of racemic D/L-phenylglycines. Thermolysin crystal and water act as the chiral stationary phase and the mobile phase, respectively. D-phenylglycine is observed to transport more slowly than L-phenylglycine, in accord with experimentally observed elution order...
December 3, 2009: Journal of Physical Chemistry. B
J V Rogers, Y W Choi
Many aspects of biodefense research require quantitative growth assessments of the test agent. This study evaluated the BioNanoPore (BNP) technology to quantitate Bacillus anthracis and Yersinia pestis faster than traditional plate counting methods. The BNP technology enabled quantification of B. anthracis and Y. pestis in phosphate-buffered saline and naïve rabbit blood at 6 and 24 h, respectively. After 6 h of growth, counts for B. anthracis ranged from 6.19-6.45 log(10) CFU ml(-1) on BNP, while counts after 24 h on tryptic soy agar (TSA) ranged from 6...
June 2009: Letters in Applied Microbiology
Zhongqiao Hu, Jianwen Jiang
The spatial and temporal properties of water and ions in bionanoporous materials-protein crystals-have been investigated using molecular dynamics simulations. Three protein crystals are considered systematically with different morphologies and chemical topologies: tetragonal lysozyme, orthorhombic lysozyme, and tetragonal thermolysin. It is found that the thermal fluctuations of C(alpha) atoms in the secondary structures of protein molecules are relatively weak due to hydrogen bonding. The solvent-accessible surface area per residue is nearly identical in the three protein crystals; the hydrophobic and hydrophilic residues in each crystal possess approximately the same solvent-accessible surface area...
April 15, 2008: Langmuir: the ACS Journal of Surfaces and Colloids
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