keyword
MENU ▼
Read by QxMD icon Read
search

trans

keyword
https://www.readbyqxmd.com/read/29679762/scavenger-receptor-b-promotes-bacteria-clearance-by-enhancing-phagocytosis-and-attenuates-white-spot-syndrome-virus-proliferation-in-scylla-paramamosian
#1
Tongtong Kong, Yi Gong, Yan Liu, Xiaobo Wen, Ngoc Tuan Tran, Jude Juventus Aweya, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Phagocytosis and apoptosis are key cellular innate immune responses against bacteria and virus in invertebrates. Class B scavenger receptors (SRBs), which contain a CD36 domain, are critical pattern recognition receptors (PRRs) of phagocytosis for bacteria and apoptotic cells. In the present study, we identified a member of SRB subfamily in mud crab Scylla paramamosain, named Sp-SRB. The full-length cDNA of Sp-SRB is 2593 bp with a 1629 bp open reading frame (ORF) encoding a putative protein of 542 amino acids, and predicted to contain a CD36 domain with two transmembrane regions at the C- and N-terminals...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679733/il-6-trans-signalling-mediates-trabecular-but-not-cortical-bone-loss-after-ovariectomy
#2
Leah Lazzaro, Brett A Tonkin, Ingrid J Poulton, Narelle E McGregor, Walter Ferlin, Natalie A Sims
Bone loss associated with estrogen deficiency occurs due to a high level of bone remodelling, with a greater increase in the level of osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Early studies showed that Interleukin-6 (IL-6) inhibition could prevent the increase in osteoclast numbers associated with ovariectomy. However, IL-6 signals through two possible pathways: classic IL-6 signalling (cis) utilizes a membrane-bound IL-6 receptor (IL-6R), while IL-6 trans-signalling occurs through a soluble IL-6R (sIL-6R)...
April 18, 2018: Bone
https://www.readbyqxmd.com/read/29679455/light-induced-bending-of-needle-like-crystals-of-naphthylvinylbenzoxazole-triggered-by-trans-cis-isomerization
#3
Jiang Peng, Jinyu Zhao, Kaiqi Ye, Hongqiang Gao, Jingbo Sun, Ran Lu
We synthesized new diarylethene derivatives bearing benzoxazole (NBO) and benzothiazole (NBT). It was found that the light-induced trans-cis isomerization of NBO and NBT took place in crystals, and it only induced the needle-like crystals of NBO to bend backwards the UV light source. We deemed that the movement of the atoms would take place during the isomerization of NBO, hence, the strain would be produced and accumulated rapidly in the surface of crystals exposed to UV light. The uniform release of the strain led to the bending of needle-like crystals...
April 20, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29679373/cytokine-producing-b-cells-promote-immune-mediated-bile-duct-injury-in-murine-biliary-atresia
#4
Joseph Bednarek, Brianna Traxinger, Dania Brigham, Jonathan Roach, David Orlicky, Dong Wang, Roberta Pelanda, Cara L Mack
Biliary atresia (BA) is a neonatal T cell-mediated inflammatory, sclerosing cholangiopathy. In the Rhesus rotavirus (RRV)-induced neonatal mouse model of BA (murine BA), mice lacking B cells do not develop BA, and the lack of B cells is associated with loss of T cell and macrophage activation. The aim of this study was to determine the mechanism of B cell-mediated immune activation (antigen presentation versus cytokine production) in murine BA. RESULTS: Normal neonatal B cells in the liver are predominantly at pro-B and pre-B cellular development...
April 20, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29679239/comparative-analysis-of-the-root-transcriptomes-of-cultivated-and-wild-rice-varieties-in-response-to-magnaporthe-oryzae-infection-revealed-both-common-and-species-specific-pathogen-responses
#5
Lei Tian, Shaohua Shi, Fahad Nasir, Chunling Chang, Weiqiang Li, Lam-Son Phan Tran, Chunjie Tian
BACKGROUND: Magnaporthe oryzae, the causal fungus of rice blast disease, negatively impacts global rice production. Wild rice (Oryza rufipogon), a relative of cultivated rice (O. sativa), possesses unique attributes that enable it to resist pathogen invasion. Although wild rice represents a major resource for disease resistance, relative to current cultivated rice varieties, no prior studies have compared the immune and transcriptional responses in the roots of wild and cultivated rice to M...
April 20, 2018: Rice
https://www.readbyqxmd.com/read/29679149/totally-endoscopic-implant-to-effect-a-gastric-bypass-12-month-safety-and-efficacy-outcomes
#6
Bryan J Sandler, Laurent Biertho, Mehran Anvari, Roberto Rumbaut, Luis Alonso Morales-Garza, Gustavo Torres-Barrera, Simon Marceau, Dennis Hong, C Daniel Smith, Santiago Horgan
BACKGROUND: Only a small percentage of candidates for bariatric surgery ever undergo a procedure for weight loss. Devices duplicating key effects of bariatric surgeries with removable, fully trans-oral implants could extend their benefits to patients unwilling to undergo anatomy-altering abdominal surgeries. METHODS: Thirty-two obese subjects (mean BMI: 42.3) were enrolled in a prospective, multicenter, single-arm, feasibility trial of the first fully trans-oral endoscopic gastrointestinal bypass device...
April 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29679052/differential-contribution-of-cis-and-trans-gene-transcription-regulatory-mechanisms-in-amygdala-and-prefrontal-cortex-and-modulation-by-social-stress
#7
Eli Reuveni, Dmitry Getselter, Oded Oron, Evan Elliott
While both individual transcription factors and cis-acting sites have been studied in relation to psychiatric disorders, there is little knowledge of the relative contribution of trans-acting and cis-acting factors to gene transcription in the brain. Using an RNA-seq approach in mice bred from two evolutionary-distinct mice strains, we determined the contribution of cis and trans factors to gene expression in the prefrontal cortex and amygdala, two regions of the brain relevant to the stress response, and the contribution of cis and trans factors in the prefrontal cortex after Chronic Social Defeat (CSD) in mice...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679037/the-therapeutic-potential-and-molecular-mechanism-of-isoflavone-extract-against-psoriasis
#8
Hsin-Ju Li, Nan-Lin Wu, Gon-Ann Lee, Chi-Feng Hung
Psoriasis is a common inflammatory disease. It affects 1-3% of the population worldwide and is associated with increasing medical costs every year. Typical psoriatic skin lesions are reddish, thick, scaly plaques that can occur on multiple skin sites all over the body. Topical application of imiquimod (IMQ), a toll-like receptor (TLR)7 agonist and potent immune system activator, can induce and exacerbate psoriasis. Previous studies have demonstrated that isoflavone extract has an antioxidant effect which may help decrease inflammation and inflammatory pain...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678743/the-orphan-nuclear-receptor-nr4a1-attenuates-oxidative-stress-induced-%C3%AE-cells-apoptosis-via-up-regulation-of-glutathione-peroxidase-1
#9
Yingfeng Yang, Fangyu Xie, Dandan Qin, Chen Zong, Feng Han, Zeqing Pu, Dong Liu, Xia Li, Yuchao Zhang, Yuantao Liu, Xiangdong Wang
AIMS: Our previous study showed that NR4A1 protects against oxidative stress-induced cell apoptosis. However, the targets downstream of NR4A1 are incompletely known. Glutathione peroxidase 1 (GPX1) is the most common antioxidant enzyme in the glutathione peroxidase class. In this study, we aimed to investigate whether GPX1 is a mediator of the protective effects of NR4A1 in pancreatic β cells. MAIN METHODS: A pancreatic β cell line, MIN6, was used to generate NR4A1 over-expression cell line...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29678458/immunization-of-balb-c-mice-with-a-combination-of-four-recombinant-brucella-abortus-proteins-aspc-dps-inpb-and-ndk-confers-a-marked-protection-against-a-virulent-strain-of-brucella-abortus
#10
Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Alisha Wehdnesday Bernardo Reyes, WonGi Min, Hu Jang Lee, Soo Jong Park, Hong Hee Chang, Suk Kim
In this study, we assessed the protective efficacy of single subunit vaccines, encoded by the B. abortus 544 genes aspC, dps, yaeC and inpB, against B. abortus infection in mice. First, immunization with these antigens, with the exception of the YaeC protein, was found to elicit both humoral and cellular immune responses with IgG2a being dominant over IgG1. In addition, a massive production of IFN-γ but lower degree of IL-10 was observed, suggesting that all three antigens were able to induce predominantly cell-mediated immunity in response to B...
April 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29678001/a-qualitative-evaluation-of-a-decision-support-system-for-district-level-disease-surveillance-in-sierra-leone
#11
Meenal Pore, Anna-Lena Arnold, Purity Mugambi, Ralph Myers, David Sengeh, Tom Sesay, Anh-Minh Tran
A decision support system for district-level disease surveillance was piloted with the Port Loko District Health Management Team in Sierra Leone. Through a qualitative evaluation, the study explores the impact of the system on disease surveillance workflows. Results indicate that the system aided decision making for operational tasks, and reduced the time taken to analyze and report surveillance data. In addition, the study discusses the challenges of deploying a pilot system during the Ebola recovery in Sierra Leone, and proposes a high-level architecture for a modular, interoperable decision support system for disease surveillance for public health decision makers in low-resource health systems...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677745/one-pot-synthesis-of-magnesium-aminoclay-titanium-dioxide-nanocomposites-for-improved-photocatalytic-performance
#12
Vu K H Bui, Duckshin Park, Vinh V Tran, Go-Woon Lee, Seo Yeong Oh, Yun Suk Huh, Young-Chul Lee
TiO2 nanoparticles (NPs) with their excellent photocatalytic performance are among the hottest research subjects for environmental-cleanup applications. In the present work, we developed a method of one-pot synthesis of magnesium aminoclay-titanium dioxide [MgAC-TiO2] nanocomposites in ethanol solution and then treated the obtained nanocomposites in a 350 °C muffle furnace for 3 hours. The obtained X-ray diffraction (XRD) patterns confirmed the growth of the anatase TiO2 NPs in the amorphous MgAC phase. In the scanning electron microscopy (SEM) morphological observation, the MgAC-TiO2 nanocomposites exhibited an aggregate form of 246...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677631/enhancement-of-monoclonal-antibody-production-after-single-and-combination-treatment-of-the-hybridoma-cells-with-all-trans-retinoic-acid-and-docosahexaenoic-acid-an-in-vitro-and-in-vivo-study
#13
Mohsen Rokni, Ali Reza Razavi, Fazel Shokri, Kazem Ahmadi Kia, Farid Solaymani-Mohammadi, Reza Chahardoli, Ali Akbar Saboor-Yaraghi
Murine hybridoma cells can produce monoclonal antibody (MAb) and the production of these antibodies in culture and peritoneum can be affected by different factors, including stimulants, inhibitors and supplements. Among these factors, the impact of micronutrients on the production of MAbs by mouse hybridoma cells has not fully been explored. In this study the murine hybridoma cells, M3C5, were cultured and treated with different concentrations of ATRA and DHA, alone, in combinations, and at different time of exposure...
April 17, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29677516/structural-basis-for-teneurin-function-in-circuit-wiring-a-toxin-motif-at-the-synapse
#14
Jingxian Li, Moran Shalev-Benami, Richard Sando, Xian Jiang, Amanuel Kibrom, Jie Wang, Katherine Leon, Christopher Katanski, Olha Nazarko, Yue C Lu, Thomas C Südhof, Georgios Skiniotis, Demet Araç
Teneurins (TENs) are cell-surface adhesion proteins with critical roles in tissue development and axon guidance. Here, we report the 3.1-Å cryoelectron microscopy structure of the human TEN2 extracellular region (ECR), revealing a striking similarity to bacterial Tc-toxins. The ECR includes a large β barrel that partially encapsulates a C-terminal domain, which emerges to the solvent through an opening in the mid-barrel region. An immunoglobulin (Ig)-like domain seals the bottom of the barrel while a β propeller is attached in a perpendicular orientation...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677354/retinoic-acid-maintains-function-of-neural-crest-derived-ocular-and-craniofacial-structures-in-adult-zebrafish
#15
Bahaar Chawla, William Swain, Antionette L Williams, Brenda L Bohnsack
Purpose: Retinoic acid (RA) is required for embryonic formation of the anterior segment of the eye and craniofacial structures. The present study further investigated the role of RA in maintaining the function of these neural crest-derived structures in adult zebrafish. Methods: Morphology and histology were analyzed by using live imaging, methylacrylate sections, and TUNEL assay. Functional analysis of vision and aqueous humor outflow were assayed with real-time imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29676920/aliphatic-c-h-bond-oxidation-with-hydrogen-peroxide-catalyzed-by-manganese-complexes-directing-selectivity-through-torsional-effects
#16
Michela Milan, Massimo Bietti, Miquel Costas
Substituted N-cyclohexyl amides undergo aliphatic C-H bond oxidation with H2 O2 catalyzed by manganese complexes. The reactions are directed by torsional effects leading to site-selective oxidation of cis-1,4-, trans-1,3-, and cis-1,2-cyclohexanediamides. The corresponding diastereoisomers are unreactive under the same conditions. Competitive oxidation of cis- trans mixtures of 4-substituted N-cyclohexylamides leads to quantitative conversion of the cis-isomers, allowing isolation and successive conversion of the trans-isomers into densely functionalized oxidation products with excellent site selectivity and good enantioselectivity...
April 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29676822/site-selective-trans-hydrostannation-of-1-3-and-1-n-diynes-application-to-the-total-synthesis-of-typhonosides-e-and-f-and-a-fluorinated-cerebroside-analogue
#17
Alois Fürstner, Xiaobin Mo, Aurelien Letort, Dragos-Adrian Rosca, Kosuge Higashida
Propargyl alcohols are privileged substrates for stereochemically unorthodox trans-hydrostannation reactions catalyzed by [Cp*RuCl]4, because an incipient hydrogen bond between the -OH group and the polarized [RuCl] unit assists substrate binding. For this very reason it is also possible to subject diyne derivatives carrying one -OH group to site-selective stannylation, even if the acetylene units are conjugated and hence electronically coupled. An unusual temperature dependence was observed in that heating tends to improve site-selectivity, whereas per-stannylation is favored when the reaction is carried out in the cold...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29676596/lung-dendritic-cells-drive-nk-cytotoxicity-in-chronic-obstructive-pulmonary-disease-via-il-15r%C3%AE
#18
Donna K Finch, Valerie R Stolberg, John Ferguson, Henrih Alikaj, Mohamed R Kady, Bradley W Richmond, Vasiliy V Polosukhin, Timothy S Blackwell, Lisa McCloskey, Jeffrey L Curtis, Christine M Freeman
RATIONALE: Lung natural killer (NK) cells kill a greater percentage of autologous lung parenchymal cells in COPD than in non-obstructed smokers. To become cytotoxic, NKs require priming, typically by dendritic cells (DC), but whether priming occurs in the lungs in COPD is unknown. METHODS: We used lung tissue and in some cases peripheral blood from patients undergoing clinically-indicated resections to determine in vitro killing of CD326+ lung epithelial cells by isolated lung CD56+ NKs...
April 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29676594/four-new-phenolic-constituents-from-the-rhizomes-of-gastrodia-elata-blume
#19
Zhi-Wei Wang, Yun Li, Da-Hui Liu, Yan Mu, Hong-Jing Dong, Hong-Lei Zhou, Lan-Ping Guo, Xiao Wang
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC50 values of 10.5 and 10.2 μM, respectively.
April 20, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29676205/effects-of-peptidyl-prolyl-isomerase-1-depletion-in-animal-models-of-prion-diseases
#20
Giuseppe Legname, Tommaso Virgilio, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Marcella Catania, Paola Zago, Elisa Isopi, Ilaria Campagnani, Fabrizio Tagliavini, Giorgio Giaccone, Fabio Moda
Pin1 is a peptidyl-prolyl isomerase that induces the cis-trans conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1+/+ ), hemizygous (Pin1+/- ) or knock-out (Pin1-/- ) background for Pin1 were experimentally infected with RML prions...
April 20, 2018: Prion
keyword
keyword
2390
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"