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JOURNAL ARTICLE
Tina R Goldstein, John Merranko, Danella Hafeman, Mary Kay Gill, Fangzi Liao, Craig Sewall, Heather Hower, Lauren Weinstock, Shirley Yen, Benjamin Goldstein, Martin Keller, Michael Strober, Neal Ryan, Boris Birmaher
OBJECTIVES: To build a one-year risk calculator (RC) to predict individualized risk for suicide attempt in early-onset bipolar disorder. METHODS: Youth numbering 394 with bipolar disorder who completed ≥2 follow-up assessments (median follow-up length = 13.1 years) in the longitudinal Course and Outcome of Bipolar Youth (COBY) study were included. Suicide attempt over follow-up was assessed via the A-LIFE Self-Injurious/Suicidal Behavior scale. Predictors from the literature on suicidal behavior in bipolar disorder that are readily assessed in clinical practice were selected and trichotomized as appropriate (presence past 6 months/lifetime history only/no lifetime history)...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#22
JOURNAL ARTICLE
Lori L Altshuler, Trisha Suppes, David O Black, Willem A Nolen, Gabriele Leverich, Paul E Keck, Mark A Frye, Ralph Kupka, Susan L McElroy, Heinz Grunze, Christina M R Kitchen, Robert Post
OBJECTIVES: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. METHODS: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with bipolar II disorder, two with bipolar disorder not otherwise specified) were treated with one of three antidepressants as an adjunct to mood stabilizers. The patients' switch rates were assessed...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#23
JOURNAL ARTICLE
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Excess mortality is a critical hallmark of bipolar disorder (BD) due to co-occurring general medical disorders and especially from suicide. It is timely to review of the status of suicide in BD and to consider the possibility of limiting suicidal risk. METHODS: We carried out a semi-systematic review of recent research reports pertaining to suicide in BD. FINDINGS: Suicide risk in BD is greater than with most other psychiatric disorders...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#24
REVIEW
Jennifer Nicoloro-SantaBarbara, Marzieh Majd, Kamilla Miskowiak, Katharine Burns, Benjamin I Goldstein, Katherine E Burdick
Bipolar disorder is associated with cognitive deficits, which persist across mood states and affect functional outcomes. This article provides an overview of recent progress in measuring cognition in bipolar disorder and its implications for both research and clinical practice. The authors summarize work conducted over the past decade that has helped guide researchers and clinicians in the appropriate measurement of cognitive functioning in bipolar disorder, the design of research studies targeting this domain for treatment, and the implementation of screening and psychoeducational tools in the clinic...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#25
REVIEW
Kamyar Keramatian, Nellai K Chithra, Lakshmi N Yatham
Bipolar disorder is a complex and heterogeneous psychiatric condition that affects more than 2% of the population. The assessment and treatment of bipolar disorder can be a challenge for clinicians, given its clinical complexity and the rapidly changing treatment landscape with the growing range of treatment options that are becoming available for various phases of the illness. To help clinicians navigate the complexity involved in the assessment and management of bipolar disorder, the guidelines of the 2018 Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) synthesized the evidence on the efficacy, safety, and tolerability of treatments for bipolar disorder and translated it into first-, second-, and third-line treatment recommendations...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#26
JOURNAL ARTICLE
Katherine E Burdick, Caitlin E Millett, Anastasia K Yocum, Cara M Altimus, Ole A Andreassen, Valerie Aubin, Raoul Belzeaux, Michael Berk, Joanna M Biernacka, Hilary P Blumberg, Anthony J Cleare, Claudia Diaz-Byrd, Caroline Dubertret, Bruno Etain, Lisa T Eyler, Brent P Forester, Janice M Fullerton, Mark A Frye, Sébastien Gard, Ophelia Godin, Emmanuel Haffen, Federica Klaus, Trine Vik Lagerberg, Marion Leboyer, Anabel Martinez-Aran, Susan McElroy, Philip B Mitchell, Emilie Olie, Phebe Olorunfemi, Christine Passerieux, Amy T Peters, Daniel L Pham, Mircea Polosan, Julia R Potter, Martha Sajatovic, Ludovic Samalin, Raymund Schwan, Megan Shanahan, Brisa Solé, Rebecca Strawbridge, Amanda L Stuart, Ivan Torres, Torrill Ueland, Eduard Vieta, Lana J Williams, Anna L Wrobel, Lakshmi N Yatham, Allan H Young, Andrew A Nierenberg, Melvin G McInnis
OBJECTIVES: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. METHODS: Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#27
JOURNAL ARTICLE
Ayyub Sabbah, Shekoofeh Mottaghi, Parviz Ghaedi, Melika Ghalandari
BACKGROUND: Differential diagnosis of bipolar II disorder (BD-II) and borderline personality disorder (BPD) has always been challenging for clinicians due to symptoms' overlap. This study aimed to compare hot and cold executive functions (EFs) in BD-II patients, as well as BPD and healthy controls (HCs), in order to differentiate these two disorders. METHODS: In the present study, 30 BD-II and 30 BPD patients undergoing the drug therapy with mood stabilizers, and 30 HC were examined using EFs evaluated tests...
May 2024: Annals of Medicine and Surgery
#28
REVIEW
Lindsay R Standeven, Annie Ho, Liisa Hantsoo
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Individuals with PCOS report reduced quality of life compared with those without PCOS, with possible contributing factors including infertility, hirsutism, irregular menses, and weight gain. Recent literature also supports increased associations between PCOS and co-occurring psychiatric conditions, particularly depression, anxiety, bipolar disorder, and eating disorders. It is concerning that a higher prevalence of suicidal ideation has been observed in individuals with PCOS...
January 2024: Focus: Journal of Life Long Learning in Psychiatry
#29
REVIEW
Caitlin Hasser, Maithri Ameresekere, Christina Girgis, Jacquelyn Knapp, Riva Shah
The authors reviewed the literature, published between 2018 and 2023, on treating bipolar disorder in the perinatal period in order to summarize current treatment perspectives. Mood episodes occur during pregnancy and there are high rates of both initial onset and recurrence in the postpartum period. Bipolar disorder itself is associated with higher risks of adverse pregnancy outcomes, including gestational hypertension, hemorrhage, cesarean delivery, and small for gestational age infants. A general principle of perinatal treatment includes maintaining psychiatric stability of the pregnant person while reducing medication exposure risk to the fetus...
January 2024: Focus: Journal of Life Long Learning in Psychiatry
#30
JOURNAL ARTICLE
Yasuyuki Matsumoto, Hitoshi Sakurai, Yumi Aoki, Yoshikazu Takaesu, Isa Okajima, Hisateru Tachimori, Masami Murao, Taku Maruki, Takashi Tsuboi, Koichiro Watanabe
OBJECTIVE: Depression significantly impacts the job performance and attendance of workers, leading to increased absenteeism. Predicting occupational engagement for individuals with depression is of paramount importance. This study aims to determine the cut-off score which predicts continuous employment for patients with mood disorders using the Quick Inventory of Depressive Symptomatology, Self-Report (QIDS-SR). METHODS: In a prospective observational trial conducted in Tokyo, 111 outpatients diagnosed with either major depressive disorder or bipolar depression were enrolled...
2024: Frontiers in Psychiatry
#31
JOURNAL ARTICLE
Ramzi Halabi, Christina Gonzalez-Torres, Stephane MacLean, M Ishrat Husain, Abhishek Pratap, Martin Alda, Benoit H Mulsant, Abigail Ortiz
Bipolar disorder (BD) is a mood disorder with different phases alternating between euthymia, manic or hypomanic episodes, and depressive episodes. While motor abnormalities are commonly seen during depressive or manic episodes, not much attention has been paid to postural abnormalities during periods of euthymia and their association with illness burden. We collected 24-hour posture data in 32 euthymic participants diagnosed with BD using a shirt-based wearable. We extracted a set of nine time-domain features, and performed unsupervised participant clustering...
May 1, 2024: IEEE Journal of Biomedical and Health Informatics
#32
Stefano Pini, Accursio Raia, Giulia Amatori, Benedetta Nardi, Barbara Carpita, Antonio Tundo, Liliana Dell'Osso
Mixed depressive states are defined by the co-presence of depressive and manic symptoms. They represent extremely variable conditions from the point of view of clinical expressiveness and are difficult to recognize, ranging from clear schizophrenic-like psychoses and pseudodemented pictures to subsyndromal psychopathology. At the basis of the extreme variability of depressive pictures with mixed features are the different combinations that depressive and manic symptoms can assume. Furthermore, the intensity of depressive symptoms and manic symptoms, combined, can be variable, a factor that contributes to making the picture even more variable...
2024: Archive of clinical cases
#33
JOURNAL ARTICLE
Taro Kishi, Nakao Iwata, Hiroyuki Irie, Masaru Aikawa
AIM: This study aimed to verify the real-world efficacy and safety of quetiapine fumarate extended-release tablets (Bipresso® 50 mg and 150 mg; marketing authorization holder is KYOWA Pharmaceutical Industry Co., Ltd., Osaka, Japan) in patients with bipolar depression. METHODS: We performed a post-marketing surveillance with an observation period of 12 weeks. RESULTS: In the safety analysis group (n = 345), adverse drug reactions (ADRs) occurred in 111 patients (32...
April 30, 2024: Neuropsychopharmacology Reports
#34
REVIEW
Jithin Thekkelkuthiyathottil Joseph, Rashmi Vishwanath, Samir Kumar Praharaj
BACKGROUND: Endoxifen, a protein kinase C inhibitor and selective estrogen receptor modulator, primarily used in breast cancer treatment, has recently emerged as a potential therapeutic option for managing manic episodes associated with bipolar disorder (BD). This review aims to assess the existing evidence base for endoxifen in BD treatment and evaluate the strengths and limitations of current research findings. METHODS: A systematic search was conducted on Medline, Embase, and Web of Science databases...
April 29, 2024: Human Psychopharmacology
#35
JOURNAL ARTICLE
Yanli Li, Leilei Wang, Junchao Huang, Ping Zhang, Yanfang Zhou, Jinghui Tong, Wenjin Chen, Mengzhuang Gou, Baopeng Tian, Wei Li, Xingguang Luo, Li Tian, L Elliot Hong, Chiang-Shan R Li, Yunlong Tan
BACKGROUND: Many studies showed disrupted tryptophan metabolism in patients with affective disorders. The aims of this study were to explore the differences in the metabolites of tryptophan pathway (TP) and the relationships between TP metabolites and clinical symptoms, therapeutic effect in patients with bipolar disorder with acute manic episode (BD-M), depressive episode (BD-D) and major depressive disorder (MDD). METHODS: Patients with BD-M (n=52) and BD-D (n=39), MDD (n=48) and healthy controls (HCs, n=49) were enrolled...
2024: Frontiers in Psychiatry
#36
JOURNAL ARTICLE
Mauro Giovanni Carta, Michele Fornaro, Diego Primavera, Antonio Egidio Nardi, Elie Karam
A syndrome centered on the dysregulation of behavioral rhythms (DBR) is discussed. Recent pandemic brought to observe: (1) Having a DBR affecting sleep patterns, eating habits, and social interactions, before the lockdown period, was a determinant for depressive episodes during the lockdown; (2) In tighter lockdowns, DBR triggered depressive episodes in bipolar patients; (3) DBR in healthcare workers under pressure was a determinant of burnout; (4) DBR influenced the course of chronic diseases by altering immune responses...
April 2024: Journal of Public Health Research
#37
JOURNAL ARTICLE
A A Akhmedova, L N Gorobets
OBJECTIVE: To determine the clinical and psychopathological features of affective disorders in women in the perimenopausal and early postmenopausal periods. MATERIAL AND METHODS: The study included 90 female patients receiving inpatient psychiatric care for affective disorders, among them 41 patients were perimenopausal (group 1) and 49 were early postmenopausal (group 2). Clinical and psychopathological, psychometric (the Hospital Anxiety and Depression Scale - HADS, the Hamilton Depression and Anxiety Scales - HAM-D and HAM-A, the Hypomania Checklist-32 - HCL-32, the Bipolarity Index (BI), the Insomnia Severity Index - ISI, the Pittsburgh Sleep Quality Index - PSQI) and statistical methods were used...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#38
REVIEW
I Yu Dorozhenok, A V Strukova
The review discusses aspects of the use of atypical antipsychotics in the treatment of depression in affective disorders and schizophrenia using the model of aripiprazole, a partial agonist of dopamine receptors. According to numerous studies, aripiprazole is the drug of choice for augmentative therapy of major depressive disorder, as well as for relieving and long-term maintenance monotherapy and combination therapy of various affective episodes of bipolar affective disorder and depression in schizophrenia...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#39
REVIEW
Riccardo Bortoletto, Anna Candolo, Alessandra Nicotra, Luana Saetti, Laura Perini, Matteo Balestrieri, Marco Colizzi, Carla Comacchio
Dandy-Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy-Walker variant (DWV) and a comorbid complex neuropsychiatric presentation, who was diagnosed with an eating disorder, obsessive-compulsive disorder, and a tic disorder. Afterwards, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review reappraising all evidence of psychiatric outcomes in adults with DWC...
April 6, 2024: Brain Sciences
#40
JOURNAL ARTICLE
Differences in schizophrenia treatments by race and ethnicity-analysis of electronic health records.
Candice Medina, Ayooluwa Akinkunmi, Nevaeh Bland, Eva Velthorst, Avi Reichenberg, Vahe Khachadourian, Amirhossein Modabbernia, Magdalena Janecka
Racial disparities in prescriptions of anti-psychotics have been highlighted before. However, (i) the evidence on other medications, including anti-depressant or mood stabilizing medications is lacking, and (ii) the role of potentially confounding factors and (iii) specificity of such disparities to schizophrenia (SCZ), are still unknown. We used electronic health records (EHRs) from 224,212 adults to estimate the odds ratios of receiving a prescription for different nervous system medications among patients with SCZ of different race/ethnicity, and analogous linear models to investigate differences in prescribed medication doses...
April 26, 2024: Schizophrenia (Heidelb)
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