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Bipolar mood disorder

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https://www.readbyqxmd.com/read/29790107/the-role-of-pharmacogenomics-in-bipolar-disorder-moving-towards-precision-medicine
#1
REVIEW
Claudia Pisanu, Urs Heilbronner, Alessio Squassina
Bipolar disorder (BD) is a common and disabling psychiatric condition with a severe socioeconomic impact. BD is treated with mood stabilizers, among which lithium represents the first-line treatment. Lithium alone or in combination is effective in 60% of chronically treated patients, but response remains heterogenous and a large number of patients require a change in therapy after several weeks or months. Many studies have so far tried to identify molecular and genetic markers that could help us to predict response to mood stabilizers or the risk for adverse drug reactions...
May 22, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29789269/anterior-cingulate-cortex-glutamatergic-metabolites-and-mood-stabilizers-in-euthymic-bipolar-i-disorder-patients-a-proton-magnetic-resonance-spectroscopy-study
#2
Marcio Gerhardt Soeiro-de-Souza, Maria Concepcion Garcia Otaduy, Rodrigo Machado-Vieira, Ricardo Alberto Moreno, Fabiano G Nery, Claudia Leite, Beny Lafer
BACKGROUND: Bipolar disorder is a chronic and recurrent illness characterized by depressive and manic episodes. Proton magnetic resonance spectroscopy (1 H-MRS) studies have demonstrated glutamate (Glu) system abnormalities in BD, but it is unclear how Glu varies among mood states and how medications modulate it. The objective of this study was to investigate the influence of mood stabilizers on anterior cingulate cortex Glu levels using 1 H-MRS during euthymia. METHODS: One hundred twenty-eight bipolar I disorder (BDI) euthymic subjects and 80 healthy control subjects underwent 3T brain 1 H-MRS imaging examination including acquisition of an anterior cingulate cortex single voxel (8 cm3 ) 1 H-MRS, based on a point resolved spectroscopy (PRESS) sequence with an echo time of 80 ms and a repetition time of 1500 ms (BIPUSP MRS study)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29785673/the-impact-of-transcranial-direct-current-stimulation-tdcs-on-bipolar-depression-mania-and-euthymia-a-systematic-review-of-preliminary-data
#3
Clément Dondé, Nicholas H Neufeld, Pierre A Geoffroy
The neurobiological basis of bipolar disorders (BD) has received increased attention and several brain regions and brain circuits have been correlated with clinical symptoms. These brain regions and circuits may represent targets for neuromodulation techniques such as transcranial Direct Current Stimulation (tDCS). We systematically reviewed the literature to explore the risks and benefits of tDCS in BD and examined all mood states. Following the PRISMA guidelines, a systematic literature search using several databases was performed from April 2002 to June 2017...
May 21, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29778054/at-risk-symptoms-of-bipolar-disorder-in-a-university-student-cohort
#4
Ida S Haussleiter, Sandra Lorek, Eike Zeschel, Svenja Mattausch, Milena Meyers, Georg Juckel
To assess the occurrence and frequency of bipolar at-risk symptoms in a large sample of previously undiagnosed students using the new screening tool Bochumer Screeningbogen Bipolar (BSB). 2329 students of the Ruhr-University Bochum, Germany completed online demographic data as well as various self-rating questionnaires (BSB; Hypomania Checklist 32; Altman Self-Rating Mania Scale; Beck Depression Inventory). Within the student cohort (64.4% female, mean age 24.3 years) every fifth student currently suffered from moderate to severe depressive symptoms; every sixth student had already thought about suicide and every other student reported a history of mood swings...
May 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29776774/association-of-disrupted-circadian-rhythmicity-with-mood-disorders-subjective-wellbeing-and-cognitive-function-a-cross-sectional-study-of-91-105-participants-from-the-uk-biobank
#5
Laura M Lyall, Cathy A Wyse, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Carlos A Celis Morales, Stephany M Biello, Daniel Mackay, Joey Ward, Rona J Strawbridge, Jason M R Gill, Mark E S Bailey, Jill P Pell, Daniel J Smith
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder...
May 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29766490/emotional-hyper-reactivity-and-cardiometabolic-risk-in-remitted-bipolar-patients-a-machine-learning-approach
#6
A A Dargél, F Roussel, S Volant, B Etain, R Grant, J-M Azorin, K M'Bailara, F Bellivier, T Bougerol, J-P Kahn, P Roux, V Aubin, P Courtet, M Leboyer, F Kapczinski, C Henry
OBJECTIVE: Remitted bipolar disorder (BD) patients frequently present with chronic mood instability and emotional hyper-reactivity, associated with poor psychosocial functioning and low-grade inflammation. We investigated emotional hyper-reactivity as a dimension for characterization of remitted BD patients, and clinical and biological factors for identifying those with and without emotional hyper-reactivity. METHOD: A total of 635 adult remitted BD patients, evaluated in the French Network of Bipolar Expert Centers from 2010-2015, were assessed for emotional reactivity using the Multidimensional Assessment of Thymic States...
May 15, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29764272/does-s100b-have-a-potential-role-in-affective-disorders-a-literature-review
#7
Hilda Kroksmark, Maj Vinberg
BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. AIM: To review the literature investigating the role of S100B in patients with affective disorders. METHOD: A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database...
May 15, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29756288/mixed-states-in-bipolar-and-major-depressive-disorders-systematic-review-and-quality-appraisal-of-guidelines
#8
REVIEW
N Verdolini, D Hidalgo-Mazzei, A Murru, I Pacchiarotti, L Samalin, A H Young, E Vieta, A F Carvalho
OBJECTIVE: This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states. METHOD: The MEDLINE/PubMed and EMBASE databases were systematically searched from inception to March 21st, 2018. International guidelines covering the treatment of mixed episodes, manic/hypomanic, or depressive episodes with mixed features were considered for inclusion. A methodological quality assessment was conducted with the Appraisal of Guidelines for Research and Evaluation-AGREE II...
May 13, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29747137/mood-instability-as-a-predictor-of-clinical-and-functional-outcomes-in-adolescents-with-bipolar-i-and-bipolar-ii-disorder
#9
Lisa A O'Donnell, Alissa J Ellis, Margaret M Van de Loo, Jonathan P Stange, David A Axelson, Robert A Kowatch, Christopher D Schneck, David J Miklowitz
BACKGROUND: Traditional assessment and treatment of bipolar disorder (BD) often overlooks an important feature of the illness, mood instability (MI). MI - the presence of intense, rapidly shifting emotional states - is associated with a number of poor prognostic outcomes. This study examined whether MI among adolescents with BD was cross-sectionally related to bipolar subtype (I vs. II) and prognostically associated with symptoms and functioning over 3 months. METHODS: Participants included 145 adolescents (mean age: 15...
April 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29737625/adjunctive-psychosocial-interventions-for-bipolar-disorder-some-psychotherapeutic-context-for-the-canadian-network-for-mood-and-anxiety-treatments-canmat-international-society-for-bipolar-disorders-isbd-guidelines
#10
https://www.readbyqxmd.com/read/29736131/the-association-of-insight-and-change-in-insight-with-clinical-symptoms-in-depressed-inpatients
#11
Hongbo He, Qing Chang, Yarong Ma
Background: Lack of insight has been extensively studied and was found to be adversely correlated with impaired treatment compliance and worse long term clinical outcomes among patients with schizophrenia, while not much is known about this phenonmenon in patients with severe depression. Aim: To explore the correlates of insight and its relation to symptom changes among the most seriously ill patients with affective disorders, those who require hospitalization. Methods: Patients hospitalized in a large psychiatric hospital in south China with either major depressive disorder (MDD)(N=55) or bipolar depression (BD) (N=85) based on ICD-10 diagnostic criteria were assessed with the Insight and Treatment Attitudes Questionnaire (ITAQ) one week after admission and at the time of discharge...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29734096/does-recent-mania-affect-response-to-antidepressants-in-bipolar-disorder-a-re-analysis-of-step-bd-data
#12
Zahra Mousavi, Sheri Johnson, Descartes Li
BACKGROUND: One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. METHOD: To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29734005/complexity-analysis-of-spontaneous-brain-activity-in-mood-disorders-a-magnetoencephalography-study-of-bipolar-disorder-and-major-depression
#13
Alberto Fernández, Ali H Al-Timemy, Francisco Ferre, Gabriel Rubio, Javier Escudero
BACKGROUND AND PURPOSE: The lack of a biomarker for Bipolar Disorder (BD) causes problems in the differential diagnosis with other mood disorders such as major depression (MD), and misdiagnosis frequently occurs. Bearing this in mind, we investigated non-linear magnetoencephalography (MEG) patterns in BD and MD. METHODS: Lempel-Ziv Complexity (LZC) was used to evaluate the resting-state MEG activity in a cross-sectional sample of 60 subjects, including 20 patients with MD, 16 patients with BD type-I, and 24 control (CON) subjects...
April 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29726068/lactate-in-bipolar-disorder-a-systematic-review-and-meta-analysis
#14
Heidi Kuang, Angela Duong, Hyunjin Jeong, Kassandra Zachos, Ana C Andreazza
Bipolar disorder (BD) is a debilitating mood disorder with no specific biological marker. No novel treatment has been developed specifically for BD in the last several decades. Although the pathophysiology of BD remains unclear, there is strong evidence in the literature supporting the role of mitochondrial dysfunction in BD. In this systematic review, we identified and investigated twelve studies that measure lactate, which is a direct marker for mitochondrial dysfunction, in BD patients and healthy controls...
May 4, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29726004/factors-associated-with-poor-functional-outcome-in-bipolar-disorder-sociodemographic-clinical-and-neurocognitive-variables
#15
J Sanchez-Moreno, C M Bonnin, A González-Pinto, B L Amann, B Solé, V Balanzá-Martinez, C Arango, E Jiménez, R Tabarés-Seisdedos, M P Garcia-Portilla, A Ibáñez, J M Crespo, J L Ayuso-Mateos, A Martinez-Aran, C Torrent, E Vieta
OBJECTIVE: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. METHODS: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery...
May 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29720363/users-perspectives-on-mhealth-self-management-of-bipolar-disorder-qualitative-focus-group-study
#16
Lise Switsers, Arthur Dauwe, Anneleen Vanhoudt, Hilde Van Dyck, Koen Lombaerts, Jfe Oldenburg
BACKGROUND: Recent research indicates that current mHealth apps for bipolar disorders (BDs) show crucial shortcomings. They lack important functionality, are of inconsistent quality, and are insufficiently evidence-based. mHealth apps need to be better adapted to the needs of users. The perspectives of adult service users with BD regarding mHealth apps have not been well investigated. OBJECTIVE: The objective of this study was to examine the needs and expectations of adults with BD regarding mHealth apps...
May 2, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29713845/regularity-of-self-reported-daily-dosage-of-mood-stabilizers-and-antipsychotics-in-patients-with-bipolar-disorder
#17
Maximilian Pilhatsch, Tasha Glenn, Natalie Rasgon, Martin Alda, Kemal Sagduyu, Paul Grof, Rodrigo Munoz, Wendy Marsh, Scott Monteith, Emanuel Severus, Rita Bauer, Philipp Ritter, Peter C Whybrow, Michael Bauer
BACKGROUND: Polypharmacy is often prescribed for bipolar disorder, yet medication non-adherence remains a serious problem. This study investigated the regularity in the daily dosage taken of mood stabilizers and second generation antipsychotics. METHODS: Daily self-reported data on medications taken and mood were available from 241 patients with a diagnosis of bipolar disorder who received treatment as usual. Patients who took the same mood stabilizer or second generation antipsychotic for ≥ 100 days were included...
May 1, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29710135/association-between-muscular-strength-and-cognition-in-people-with-major-depression-or-bipolar-disorder-and-healthy-controls
#18
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29709719/cerebral-processing-of-facial-emotions-in-bipolar-i-and-ii-disorders-an-event-related-potential-study
#19
Bingren Zhang, Chu Wang, Guorong Ma, Hongying Fan, Jiawei Wang, Wei Wang
BACKGROUND: Behavioral results have shown that bipolar disorder patients have impaired recognition of facial emotions, but the detailed information processing of facial emotions in patients with bipolar I (BD I) and II (BD II) disorders remain unknown. METHODS: We tested the cerebral event-related potentials to the static facial expressions of Neutral, Happiness, Anger and Sadness in 39 adult patients with BD I, 22 BD II, and 54 healthy volunteers. Participants' affective states were measured with the Mood Disorder Questionnaire, the Hypomania Checklist-32, and the Plutchik-van Praag Depression Inventory...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29708895/offspring-of-parents-with-mood-disorders-time-for-more-transgenerational-research-screening-and-preventive-intervention-for-this-high-risk-population
#20
Dominique Maciejewski, Manon Hillegers, Brenda Penninx
PURPOSE OF REVIEW: Offspring of parents with mood disorders (major depressive and bipolar disorder) are at increased risk for developing mood disorders. In this review, an overview regarding the intergenerational transmission of mood disorders, screening, and preventive intervention is given for this vulnerable group. RECENT FINDINGS: Offspring of parents with depression have a 40% chance of developing a depression, whereas offspring of parents with bipolar disorder have a 10% chance of developing a bipolar disorder by adulthood...
April 26, 2018: Current Opinion in Psychiatry
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