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https://www.readbyqxmd.com/read/28091795/mood-spectrum-disorders-and-perception-of-pain
#1
Antonella Ciaramella
: Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
January 14, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28090803/insulin-like-growth-factor-binding-protein-2-in-bipolar-disorder-an-expression-study-in-peripheral-tissues
#2
Elena Milanesi, Roberta Zanardini, Gianluca Rosso, Giuseppe Maina, Alessandro Barbon, Cristina Mora, Alessandra Minelli, Massimo Gennarelli, Luisella Bocchio-Chiavetto
OBJECTIVES: Insulin-like Growth Factor Binding Protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system. This study aimed to investigate the putative involvement of IGFBP2 in mood disorder pathogenesis by measuring its expression levels in patient peripheral tissues. METHODS: IGFBP2 protein and mRNA levels were measured in the serum of 93 controls, 41 Bipolar Disorder (BD) and 43 Major Depressive Disorder (MDD) patients and in the skin fibroblasts from 15 controls, 12 BD and 23 MDD patients...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28079488/association-analysis-of-ank3-variants-with-bipolar-disorder-in-the-korean-population
#3
Chul-Hyun Cho, Soojin Kim, Dongho Geum, Heon-Jeong Lee
BACKGROUND: Bipolar disorder (BD) is a major psychiatric disorder characterized by alternating mood episodes, including major depressive, hypomanic, and manic episodes. Previous genetic studies of BD have reported several genes as potentially associated with BD. The ANK3 gene has been identified as a possible BD susceptibility gene in genome-wide association analyses. AIMS: The goal of the present study was to evaluate the association of ANK3 variants with BD in the Korean population...
January 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28078988/bdnf-nf-kb-signaling-in-the-neurobiology-of-depression
#4
Ariel Caviedes, Carlos Lafourcade, Claudio Soto, Ursula Wyneken
BACKGROUND: Mood disorders, consisting of unipolar and bipolar depression, are complex diseases characterized by depressed mood and anhedonia. These core symptoms are accompanied in a varying manner by anxiety, several neurovegetative symptoms and cognitive impairment. Mood disorders are characterized by decreases in neurogenesis, alteration in synaptic structure and synaptic transmission, all of them regulated by BDNF, a neurotrophin that performs multiple functions in the adult central nervous system...
January 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28077175/structural-correlates-of-trait-impulsivity-in-patients-with-bipolar-disorder-and-healthy-controls-a-surface-based-morphometry-study
#5
P C Tu, Y H Kuan, C T Li, T P Su
BACKGROUND: Patients with bipolar disorder (BD) frequently exhibit impulsive behaviors independent of their mood state, and trait impulsivity is increasingly recognized as a crucial BD biomarker. This study aimed to investigate structural correlates of trait impulsivity measured using the Barratt Impulsiveness Scale (BIS) in healthy controls (HCs) and patients with BD. METHOD: We recruited 59 patients diagnosed with BD I or BD II (35.3 ± 8.5 years) and 56 age- and sex-matched HCs (33...
January 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28073041/major-depressive-disorder-with-subthreshold-hypomanic-mixed-features-a-real-world-assessment-of-treatment-patterns-and-economic-burden
#6
Roger S McIntyre, Daisy Ng-Mak, Chien-Chia Chuang, Rachel Halpern, Pankaj A Patel, Krithika Rajagopalan, Antony Loebel
BACKGROUND: To compare outcomes for individuals with major depressive disorder (MDD) with or without subthreshold hypomania (mixed features) in naturalistic settings. METHODS: Using the Optum Research Database (1/1/2009─10/31/2014), a retrospective analysis of individuals newly diagnosed with MDD was conducted. Continuous enrollment for 12-months before and after the initial MDD diagnosis was required. MDD with subthreshold hypomania (mixed features) (MDD-MF) was defined based on ≥1 hypomania diagnosis within 30 days after an MDD diagnosis during the one-year follow-up period, in the absence of bipolar I diagnoses...
December 23, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28072643/early-life-trauma-in-hospitalized-patients-with-mood-disorders-and-its-association-with-clinical-outcomes
#7
Ajay K Parsaik, Noha Abdelgawad, Jigar K Chotalia, Scott D Lane, Teresa A Pigott
BACKGROUND: The prevalence of childhood trauma and its impact on clinical outcomes in hospitalized patients with mood disorders is unknown. We studied the frequency of childhood trauma among inpatient adults with mood disorders and its association with clinical outcomes. METHODS: Patients admitted to our hospital with a primary diagnosis of mood disorders completed the short form of the Early Trauma Inventory-Self-Report (ETISR-SF), the Sheehan Disability Scale, and the Clinician-Rated Dimensions of Psychosis Symptom Severity scale...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28070120/the-protocadherin-17-gene-affects-cognition-personality-amygdala-structure-and-function-synapse-development-and-risk-of-major-mood-disorders
#8
H Chang, N Hoshina, C Zhang, Y Ma, H Cao, Y Wang, D-D Wu, S E Bergen, M Landén, C M Hultman, M Preisig, Z Kutalik, E Castelao, M Grigoroiu-Serbanescu, A J Forstner, J Strohmaier, J Hecker, T G Schulze, B Müller-Myhsok, A Reif, P B Mitchell, N G Martin, P R Schofield, S Cichon, M M Nöthen, H Walter, S Erk, A Heinz, N Amin, C M van Duijn, A Meyer-Lindenberg, H Tost, X Xiao, T Yamamoto, M Rietschel, M Li
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) revealing brain expressed protocadherin 17 (PCDH17) as a susceptibility gene for major mood disorders. Single-nucleotide polymorphisms (SNPs) spanning the PCDH17 region are significantly associated with major mood disorders; subjects carrying the risk allele showed impaired cognitive abilities, increased vulnerable personality features, decreased amygdala volume and altered amygdala function as compared with non-carriers...
January 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28069365/polyunsaturated-fatty-acids-and-recurrent-mood-disorders-phenomenology-mechanisms-and-clinical-application
#9
REVIEW
Erik Messamore, Daniel M Almeida, Ronald J Jandacek, Robert K McNamara
A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Cross-national and cross-sectional evidence suggests that greater habitual intake of n-3 PUFA is associated with reduced risk for developing mood symptoms. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation...
January 6, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28068464/clinical-outcomes-in-children-and-adolescents-with-bipolar-disorder-and-substance-use-disorder-comorbidity
#10
Taiane de Azevedo Cardoso, Karen Jansen, Cristian Patrick Zeni, João Quevedo, Giovana Zunta-Soares, Jair C Soares
OBJECTIVE: To assess the global functioning and clinical outcomes of children and adolescents with bipolar disorder, children and adolescents with bipolar disorder and substance use disorder (SUD) comorbidity and healthy controls. METHODS: This study had a cross-sectional design. Participants were children and adolescents aged between 6 and 17 years, and data were collected between 2003 and 2015. Psychiatric diagnosis was established according to DSM-IV criteria using the Kiddie-SADS-Present and Lifetime Version or the Mini-International Neuropsychiatric Interview for Children and Adolescents...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28068462/extent-time-course-and-moderators-of-antipsychotic-treatment-in-youth-with-mood-disorders-results-of-a-meta-analysis-and-meta-regression-analyses
#11
Chiara Cervesi, Su Young Park, Britta Galling, Silvia Molteni, Gabriele Masi, Tobias Gerhard, Mark Olfson, Christoph U Correll
OBJECTIVE: To meta-analytically examine the trends and correlates of antipsychotic use in youth with mood disorders. METHODS: Systematic literature search without language restriction in PubMed/MEDLINE/PsycINFO from database inception through March 2015 using the following search terms: (antipsychotic* OR neuroleptic* OR "dopamine blocker*" OR antidopaminergic) AND (child* OR adolescen* OR pediatric OR youth) AND (prescription* OR prescrib* OR use OR utilization OR database OR pharmacoepidemiolog* OR frequency OR rate OR rates)...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28066002/management-of-obsessive-compulsive-disorder-comorbid-with-bipolar-disorder
#12
REVIEW
Firoz Kazhungil, E Mohandas
Obsessive-compulsive disorder (OCD) is one of the most common comorbidities in bipolar disorder (BD). Clinicians often get perplexed in making treatment decisions when encountering comorbid OCD and BD as treatment of OCD by pharmacotherapy may induce or exacerbate mood instability and psychotherapeutic approaches for OCD may not be feasible in acute manic or depressive state of BD. In this study, we reviewed literature, whether existing guideline-based treatments of BD may be effective in OCD and whether newer agents will be of use for treating this comorbidity...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28063207/lithiumeter-version-2-0
#13
Gin S Malhi, Samuel Gershon, Tim Outhred
BACKGROUND: The Lithiumeter was developed as a visual and practical guide for determining lithium levels in the management of bipolar disorder (BD). It appears to have been well received, as evidenced by its increasing popularity amongst doctors as a deskside clinical aide, and adoption and reproduction of the schematic in clinical guidelines and texts. However, since its publication 5 years ago, key basic neuroscience and clinical research developments pertaining to lithium have significantly advanced our understanding, necessitating further refinement of guidance concerning the practicalities of lithium therapy...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/28060978/-ingesta-de-hidratos-de-carbono-y-%C3%A3-cidos-grasos-de-la-dieta-en-sujetos-con-esquizofrenia-y-trastorno-bipolar-y-su-asociaci%C3%A3-n-con-par%C3%A3-metros-antropom%C3%A3-tricos
#14
Natalia Santillana T, Álvaro Cavieres F, Claudia Vega S
BACKGROUND: People with psychiatric disorders have higher rates of obesity, diabetes mellitus and dyslipidemia. These comorbidities are associated with the underlying psychopathology and drug therapy. AIM: To determine the quality and quantity of carbohydrates and fatty acids in the diet and their association with anthropometric parameters in subjects with schizophrenia and bipolar disorders. PATIENTS AND METHODS: We studied 30 patients with schizophrenia and bipolar disorders in treatment with atypical antipsychotics or mood stabilizers...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060532/critical-slowing-down-as-an-early-warning-of-transitions-in-episodes-of-bipolar-disorder-a-simulation-study-based-on-a-computational-model-of-circadian-activity-rhythms
#15
Atiyeh Bayani, Fatemeh Hadaeghi, Sajad Jafari, Greg Murray
Bipolar disorder is characterized by repeated episodes of mania and depression, and can be understood as pathological complex system behaviour involving cognitive, affective and psychomotor disturbance. Accurate prediction of episode transitions in the long-term pattern of mood changes in bipolar disorder could improve the management of the disorder by providing an objective early warning of relapse. In particular, circadian activity changes measured via actigraphy may contain clinically relevant signals of imminent systemic dysregulation...
January 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28054457/doping-control-analysis-of-lithium-in-horse-urine-and-plasma-by-inductively-coupled-plasma-mass-spectrometry
#16
Timmy L S Choi, Jenny K Y Wong, Emmie N M Ho, Wai Him Kwok, Gary N W Leung, Peter Curl, Terence S M Wan
Lithium salts are commonly prescribed to treat bipolar disorder in humans. They are effective for the treatment of acute mania and the prophylaxis of manic relapses through long-term use. Although there is no reported legitimate therapeutic use of lithium in horses, its potential mood stabilizing effect, low cost and being readily available make lithium salt a potential agent of abuse in equine sports, especially for equestrian competition horses. Lithium can be found in soil, plants and water, as such it is naturally present in the equine body, thus a threshold is necessary to control its misuse in horses...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28053535/atypical-major-depressive-episode-as-initial-presentation-of-intracranial-germinoma-in-a-male-adolescent
#17
Yi-Ting Chen, Kuan-Pin Su, Jane Pei-Chen Chang
A 17-year-old adolescent boy presented with atypical major depressive episode (MDE) without specific focal neurological signs for 6 months. He had a diagnosis of intra-cranial germinoma, and the atypical MDE symptoms subsided after the operation. However, he had a relapse of atypical MDE 7 months after the first surgery. His mood and binge eating symptoms subsided, but intractable body weight gain only partially improved after treatment. When encountering manifestations of depression with atypical features, especially with binge eating symptoms in male children and adolescents, with early onset age, no family history, and prolonged depressive episodes, clinicians should consider not only mood disorders including bipolar spectrum disorders but also organic brain lesions such as intracranial germinoma...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28049102/prevalence-and-clinical-severity-of-mood-disorders-among-first-second-and-third-generation-migrants
#18
Baptiste Pignon, Geoffroy Pierre Alexis, Pierre Thomas, Jean-Luc Roelandt, Benjamin Rolland, Craig Morgan, Guillaume Vaiva, Ali Amad
BACKGROUND: The role of migration as a risk factor remains unknown for mood disorders because of poor data. We sought to examine the prevalence and severity of mood disorders (bipolar disorder (BD), unipolar depressive disorder (UDD) and dysthymia) in first, second, and third generation migrants in France. METHODS: The Mental Health in the General Population survey interviewed 38,694 individuals. The prevalence of lifetime mood disorders, comorbidities, and clinical features was compared between migrants and non-migrants and by generation...
December 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28045139/chrna7-deficient-mice-manifest-no-consistent-neuropsychiatric-and-behavioral-phenotypes
#19
Jiani Yin, Wu Chen, Hongxing Yang, Mingshan Xue, Christian P Schaaf
The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar disorder, epilepsy, autism, Alzheimer's disease, and Parkinson's disease, and is considered a potential target for therapeutic intervention. 15q13.3 microdeletion syndrome is a rare genetic disorder, caused by submicroscopic deletions on chromosome 15q. CHRNA7 is the only gene in this locus that has been deleted entirely in cases involving the smallest microdeletions...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#20
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
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