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https://www.readbyqxmd.com/read/28211548/the-33-item-hypomania-checklist-hcl-33-a-study-of-the-consistency-between-self-and-external-assessments-in-polish-bipolar-patients
#1
Dorota Łojko, Dominika Dudek, Jules Angst, Marcin Siwek, Michał Michalak, Janusz Rybakowski
OBJECTIVES: The Hypomania Checklist (HCL) has become an important tool for the assessment of hypomanic symptoms in patients with mood disorders and in the general population. The HCL-33 scale, containing 33 symptom items, is a new instrument which, in addition to the self-administered questionnaire, has a version for external rating. The aim of this study is to evaluate the consistency between the self - and external assessments using the HCL-33 in Polish patients with bipolar disorder...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28207918/disruptive-mood-dysregulation-disorder-and-its-effect-on-bipolar-disorder
#2
Shama Faheem, Victoria Petti, George Mellos
BACKGROUND: In the last few decades, a noticeable increase in the diagnosis of bipolar disorder (BD) in youth has raised concerns, particularly because of a consequent increase in the use of psychotropic medications with adverse side effects. After observing the development of those youth into adulthood, clinicians and researchers have questioned the notion of expanding the diagnostic boundaries of BD to encapsulate these youth. METHODS: Our research is aimed at gleaning further information on disruptive mood dysregulation disorder (DMDD) and to observe whether its introduction has affected the rates of BD in children and adolescents...
February 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207916/principal-diagnoses-in-psychiatric-outpatients-with-borderline-personality-disorder-implications-for-screening-recommendations
#3
Mark Zimmerman, Iwona Chelminski, Kristy Dalrymple, Lia Rosenstein
BACKGROUND: In the Rhode Island Methods to Improve Diagnostic Assessment and Services project, we examined how often borderline personality disorder (BPD) is the principal diagnosis in patients presenting for outpatient psychiatric treatment. To inform clinicians when it is most productive to screen for BPD, we examined the prevalence of BPD in psychiatric outpatients with different principal diagnoses. METHODS: In this study, 3,674 psychiatric outpatients were evaluated with a semi-structured diagnostic interview for DSM-IV BPD...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28205606/differential-abnormal-pattern-of-anterior-cingulate-gyrus-activation-in-unipolar-and-bipolar-depression-an-fmri-and-pattern-classification-approach
#4
Christian Bürger, Ronny Redlich, Dominik Grotegerd, Susanne Meinert, Katharina Dohm, Ilona Schneider, Dario Zaremba, Katharina Förster, Judith Alferink, Jens Bölte, Walter Heindel, Harald Kugel, Volker Arolt, Udo Dannlowski
Distinguishing bipolar disorder from major depressive disorder is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate affective disorders. Thirty-six depressed bipolar patients, 36 depressed unipolar patients and 36 matched healthy controls participated in an fMRI-experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful and happy faces focusing on prototypical regions related to emotion processing, ie the amygdala and the anterior cingulate gyrus (ACG)...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28202261/hyperprolinemia-as-a-clue-in-the-diagnosis-of-a-patient-with-psychiatric-manifestations
#5
Marco Duarte, Joana Afonso, Ana Moreira, Diana Antunes, Cristina Ferreira, Hildeberto Correia, Margarida Marques, Sílvia Sequeira
Lately, microdeletions of the 22q region, responsible for DiGeorge syndrome or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorder. These manifestations seem to be related to certain genes located in the hemideleted region such as the proline dehydrogenase (PRODH) and the catechol-o-methyltransferase (COMT) genes. We describe a teenager who started his adolescent psychiatric care presenting cognitive impairment, irritable mood and aggressive behaviour with schizophrenia-like symptoms that scored 153 in the Positive and Negative Symptoms Scale (PANSS) assessment...
February 12, 2017: Brain & Development
https://www.readbyqxmd.com/read/28199068/the-relationship-between-stressful-life-events-and-axis-i-diagnoses-among-adolescent-offspring-of-probands-with-bipolar-and-non-bipolar-psychiatric-disorders-and-healthy-controls-the-pittsburgh-bipolar-offspring-study-bios
#6
Lisa A Pan, Tina R Goldstein, Brian T Rooks, Mary Hickey, Jie Yu Fan, John Merranko, Kelly Monk, Rasim S Diler, Dara J Sakolsky, Daniella Hafeman, Satish Iyengar, Benjamin Goldstein, David J Kupfer, David A Axelson, David A Brent, Boris Birmaher
BACKGROUND: Previous studies have explored the role of stressful life events in the development of mood disorders. We examined the frequency and nature of stressful life events as measured by the Stressful Life Events Schedule (SLES) among 3 groups of adolescent offspring of probands with bipolar (BD), with non-BD psychiatric disorders, and healthy controls. Furthermore, we examined the relationship between stressful life events and the presence of DSM-IV Axis I disorders in these offspring...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28196994/distressing-cutaneous-lesion-among-bipolar-affective-disorder-patients-on-lithium-therapy-a-retrospective-cross-sectional-study
#7
Syed Ummar, B Lakshmi Dorai, Shree Aarthi Ramanathan
AIM: To assess the incidence of cutaneous lesion in bipolar affective disorder (BPAD) patients on lithium therapy. To evaluate the relationship between duration of lithium therapy, dosage of lithium, serum lithium level, and cutaneous lesions. To assess whether reduction/stoppage of dose of lithium has any change in the course of cutaneous side effects. To look for a relationship between addition of isotretinoin and the course of mood disorder. METHODOLOGY: We retrospectively collected hospital case records of 125 consecutive BPAD patients initiated lithium therapy, assessed with inclusion and exclusion criteria...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28194724/ketamine-and-beyond-investigations-into-the-potential-of-glutamatergic-agents-to-treat-depression
#8
REVIEW
Marc S Lener, Bashkim Kadriu, Carlos A Zarate
Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is implicated in mood disorders such as major depressive disorder and bipolar depression. In clinical studies of individuals with major depressive disorder and bipolar depression, rapid reductions in depressive symptoms have been observed in response to subanesthetic-dose ketamine, an agent whose mechanism of action involves the modulation of glutamatergic signaling. The findings from these studies have prompted the repurposing and/or development of other glutamatergic modulators for antidepressant efficacy, both as monotherapy or as an adjunct to conventional monoaminergic antidepressants...
February 14, 2017: Drugs
https://www.readbyqxmd.com/read/28194001/enhancing-vta-cav1-3-l-type-ca-2-channel-activity-promotes-cocaine-and-mood-related-behaviors-via-overlapping-ampa-receptor-mechanisms-in-the-nucleus-accumbens
#9
A Martínez-Rivera, J Hao, T F Tropea, T P Giordano, M Kosovsky, R C Rice, A Lee, R L Huganir, J Striessnig, N A Addy, S Han, A M Rajadhyaksha
Genetic factors significantly influence susceptibility for substance abuse and mood disorders. Rodent studies have begun to elucidate a role of Cav1.3 L-type Ca(2+) channels in neuropsychiatric-related behaviors, such as addictive and depressive-like behaviors. Human studies have also linked the CACNA1D gene, which codes for the Cav1.3 protein, with bipolar disorder. However, the neurocircuitry and the molecular mechanisms underlying the role of Cav1.3 in neuropsychiatric phenotypes are not well established...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28192774/irritability-in-child-and-adolescent-psychopathology-an-integrative-review-for-icd-11
#10
REVIEW
Spencer C Evans, Jeffrey D Burke, Michael C Roberts, Paula J Fite, John E Lochman, Francisco R de la Peña, Geoffrey M Reed
In preparation for the World Health Organization's development of the Eleventh Revision of the International Classification of Diseases and Related Health Problems (ICD-11) chapter on Mental and Behavioral Disorders, this article reviews the literature pertaining to severe irritability in child and adolescent psychopathology. First, research on severe mood dysregulation suggests that youth with irritability and temper outbursts, among other features of hyperactivity and arousal, demonstrate cross-sectional correlates and developmental outcomes that distinguish them from youth with bipolar disorder...
January 17, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28188565/poor-quality-of-life-and-functioning-in-bipolar-disorder
#11
Louisa G Sylvia, Rebecca E Montana, Thilo Deckersbach, Michael E Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G McInnis, James H Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C Shelton, Susan L McElroy, Edward S Friedman, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. METHODS: Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#12
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28185899/lurasidone-versus-treatment-as-usual-for-cognitive-impairment-in-euthymic-patients-with-bipolar-i-disorder-a-randomised-open-label-pilot-study
#13
Lakshmi N Yatham, Sylvia Mackala, Jayasree Basivireddy, Sharon Ahn, Nazlin Walji, Chen Hu, Raymond W Lam, Ivan J Torres
BACKGROUND: Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. METHODS: For this randomised, open-label, pilot study, we recruited patients aged 19-65 years with euthymic bipolar I disorder from the Mood Disorder Centre in UBC Hospital (Vancouver, Canada)...
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28185785/can-antibiotics-cause-a-psychosis-case-report-and-review-of-the-literature
#14
Duy Ly, Lynn E DeLisi
It is relatively unknown that some of the possible side effects of antibiotic treatment can be transient psychotic episodes and other encephalopathies such as seizure disorders. Since these are rare events, there have not been many studies about them, nor is there a clear understanding of the underlying basis for these symptoms. This phenomenon was recently brought to our attention by a patient whose case history is discussed here. For the past few years, he has been diagnosed at different times with schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, temporal lobe epilepsy, and psychogenic nonepileptic seizures...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28184334/mixed-states-in-bipolar-disorder-etiology-pathogenesis-and-treatment
#15
REVIEW
Ather Muneer
Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states were narrowly defined in the context of bipolar I disorder, but with the advent of DSM-5 the term "mixed episode" was dropped and replaced by "mixed features" specifier which could be broadly applied to manic, hypomanic and depressive episodes in both the bipolar spectrum and major depressive disorders...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28183076/meta-analysis-of-the-risk-of-subsequent-mood-episodes-in-bipolar-disorder
#16
Joaquim Radua, Heinz Grunze, Benedikt L Amann
BACKGROUND: Reported relapse and recurrence rates in bipolar disorder (BD) differ significantly between studies. Most data originate from highly selective patients participating in sponsored randomized controlled trials with narrow inclusion criteria. To estimate the true risk of a subsequent mood episode (SME) under real-world conditions, we conducted a meta-analysis of rates of SME as reported in naturalistic BD studies. METHODS: PubMed, ScienceDirect, Scopus, and Web of Knowledge were searched until July 2015...
February 10, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28178086/identification-of-rare-nonsynonymous-variants-in-syne1-cpg2-in-bipolar-affective-disorder
#17
Sally I Sharp, Jenny Lange, Radhika Kandaswamy, Mazen Daher, Adebayo Anjorin, Nicholas J Bass, Andrew McQuillin
BACKGROUND: Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly understood; however, a strong heritable component has been identified. Previous genome-wide association studies have indicated a region on 6q25, coding for the SYNE1 gene, which increases disease susceptibility. SYNE1 encodes the synaptic nuclear envelope protein-1, nesprin-1. A brain-specific splice variant of SYNE1, CPG2 encoding candidate plasticity gene 2, has been identified...
February 7, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28173893/sleep-and-circadian-rhythm-disturbance-in-bipolar-disorder
#18
A J Bradley, R Webb-Mitchell, A Hazu, N Slater, B Middleton, P Gallagher, H McAllister-Williams, K N Anderson
BACKGROUND: Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate to underlying circadian rhythm disturbance (CRD). In this study we aimed to objectively assess sleep and circadian rhythm in a cohort of patients with BD compared to matched controls. METHOD: Forty-six patients with BD and 42 controls had comprehensive sleep/circadian rhythm assessment with respiratory sleep studies, prolonged accelerometry over 3 weeks, sleep questionnaires and diaries, melatonin levels, alongside mood, psychosocial functioning and quality of life (QoL) questionnaires...
February 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28168632/long-term-use-of-lurasidone-in-patients-with-bipolar-disorder-safety-and-effectiveness-over-2%C3%A2-years-of-treatment
#19
Andrei Pikalov, Joyce Tsai, Yongcai Mao, Robert Silva, Josephine Cucchiaro, Antony Loebel
BACKGROUND: Bipolar disorder is a chronic illness with a 2-year recurrence rate of approximately 50% among individuals receiving treatment in the community. The aim of this 18-month, open-label, continuation study was to evaluate the long-term safety and effectiveness of lurasidone in patients who initially presented with a major depressive episode associated with bipolar disorder, and who had completed at least 6 months of initial treatment with lurasidone. METHODS: Patients with bipolar I depression were enrolled in one of three 6-week, double-blind, placebo-controlled trials (monotherapy with lurasidone, 1 study; adjunctive therapy with lurasidone; and lithium or valproate, 2 studies)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28168425/the-effects-of-histone-deacetylase-inhibition-on-the-levels-of-cerebral-cytokines-in-an-animal-model-of-mania-induced-by-dextroamphetamine
#20
Samira S Valvassori, Wilson R Resende, Roger B Varela, Camila O Arent, Fernanda F Gava, Bruna R Peterle, Gustavo C Dal-Pont, André F Carvalho, Monica L Andersen, João Quevedo
Studies have suggested the involvement of inflammatory processes in the physiopathology of bipolar disorder. Preclinical evidences have shown that histone deacetylase inhibitors may act as mood-stabilizing agents and protect the brain in models of mania and depression. The aim of the present study was to evaluate the effects of sodium butyrate (SB) and valproate (VPA) on behavioral changes, histone deacetylase activity, and the levels of cytokines in an animal model of mania induced by dextroamphetamine (d-AMPH)...
February 6, 2017: Molecular Neurobiology
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