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https://www.readbyqxmd.com/read/28437764/the-use-of-lithium-for-the-treatment-of-bipolar-disorder-recommendations-from-clinical-practice-guidelines
#1
Gin S Malhi, Danielle Gessler, Tim Outhred
BACKGROUND: Lithium is an effective mood stabilizer that is used principally for the management of bipolar disorder (BD). Its administration is complex and often requires sophisticated management and assiduous monitoring. When considering the use of lithium therapy for bipolar disorder, clinicians are advised to refer to recommendations outlined in clinical practice guidelines (CPGs); but because of varying emphases placed by different international CPGs, recommendations addressing the practical use of lithium lack consistency...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28427565/analyzing-the-effect-of-v66m-mutation-in-bdnf-in-causing-mood-disorders-a-computational-approach
#2
P Sneha, D Thirumal Kumar, Sugandhi Saini, Kreeti Kajal, R Magesh, R Siva, C George Priya Doss
Mental disorders or mood disorders are prevalent globally irrespective of region, race, and ethnic groups. Of the types of mood disorders, major depressive disorder (MDD) and bipolar disorder (BPD) are the most prevalent forms of psychiatric condition. A number of preclinical studies emphasize the essential role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of mood disorders. Additionally, BDNF is the most common growth factor in the central nervous system along with their essential role during the neural development and the synaptic elasticity...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28424384/minor-physical-anomalies-and-dermatoglyphic-signs-in-affective-disorders-a-systematic-review
#3
Hajnalka Berecz, Györgyi Csábi, Róbert Herold, Daniel Trixler, Judit Fekete, Tamás Tényi
The increased prevalence of minor physical anomalies (MPAs) and the abnormalities of dermatoglyphic patterns may be physical manifestations of neurodevelopmental disruption in affective disorders. This paper aims to review the current state of knowledge on the frequency of MPAs and dermatoglyphic abnormalities in mood disorders. A MEDLINE, PsychInfo and Web of Science search was carried out to collect all publications on the frequency of MPAs and on dermatoglyphic traits in bipolar disorder and unipolar depression...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28424378/-recognition-care-and-prevention-of-suicidal-behaviour-in-adults
#4
Zoltán Rihmer, Attila Németh, Tamás Kurimay, Dóra Perczel-Forintos, György Purebl, Péter Döme
Suicide is a major public health problem everywhere in the world and in the WHO European Region suicide accounts for over 120,000 deaths per year. 1. Recognition and diagnosis: An underlying psychiatric disorder is present in up to 90% of people who completed suicide. Comorbidity with depression, anxiety, substance abuse and personality disorders is high. In order to achieve successful prevention of suicidality, adequate diagnostic procedures and appropriate treatment for the underlying disorder are essential...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28422528/effect-of-psychopharmacotherapy-on-body-mass-index-among-children-and-adolescents-with-bipolar-disorders
#5
Ayush Patel, Wenyaw Chan, Rajender R Aparasu, Melissa Ochoa-Perez, Jeff T Sherer, Rohan Medhekar, Hua Chen
OBJECTIVE: To assess the long-term effect of all treatment options for pediatric bipolar disorders on body mass index (BMI) and to explore individual characteristics associated with less BMI increase during psychotropic medication exposures. METHODS: A retrospective cohort study was conducted by using the 1995 to 2010 General Electric Electronic Medical Record database. Individuals aged 18 years or younger who had a new bipolar disorder episode were identified. Treatment exposure was defined based on the medication regimens patients received, which include atypical antipsychotic (AT) monotherapy, mood stabilizer (MS) monotherapy, antidepressant (AD) monotherapy, AT+MS polytherapy, AT+AD polytherapy, MS+AD polytherapy, and no treatment...
April 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28418197/body-mass-index-associates-with-white-matter-microstructure-in-bipolar-depression
#6
Elena Mazza, Sara Poletti, Irene Bollettini, Clara Locatelli, Andrea Falini, Cristina Colombo, Francesco Benedetti
OBJECTIVES: Obesity has been reported in over 60% of bipolar disorder (BD) patients. It worsens the severity of illness, and influences cognition and functional outcomes. White matter (WM) abnormalities are one of the most consistently reported findings in neuroimaging studies of BD. We hypothesized that body mass index (BMI) could correlate with WM integrity in bipolar patients. METHODS: We evaluated BMI in a sample of 164 depressed patients affected by BD. We performed whole-brain tract-based spatial statistics with threshold-free cluster enhancement for the diffusion tensor imaging (DTI) measures of WM integrity: fractional anisotropy; axial, radial, and mean diffusivity...
April 18, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28417647/mixed-states-in-bipolar-disorder-changes-in-dsm-5-and-current-treatment-recommendations
#7
Felix Betzler, Laura Apollonia Stöver, Philipp Sterzer, Stephan Köhler
OBJECTIVE: Mixed states in affective disorders represent a particular challenge in clinical routine, characterized by a complicated course of treatment and a worse treatment response. METHODS: Clinical features of mixed states and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria are presented and critical discussed. We then performed a systematic review using the terms 'bipolar', 'mixed' and 'randomized' to evaluate current treatment options...
April 18, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28417559/asenapine-modulates-mood-related-behaviors-and-5-ht1a-7-receptors-mediated-neurotransmission
#8
Sarah Delcourte, Erika Abrial, Adeline Etiévant, Renaud Rovera, Jørn Arnt, Michael Didriksen, Nasser Haddjeri
AIM: Asenapine is a new atypical antipsychotic prescribed for the treatment of psychosis/bipolar disorders that presents higher affinity for serotonergic than dopaminergic receptors. The objective of this study was to investigate its antidepressant-like and antimanic-like properties on relevant animal models of depression and mania and to assess the acute and chronic effect of Asenapine on dorsal raphe nucleus (DRN) 5-HT cell firing activity. METHODS: We assessed the effects of Asenapine using in vivo electrophysiological and behavioral assays in rats...
April 17, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28416033/pharmacological-treatment-of-mixed-states
#9
Alessandro Cuomo, Viktoriya L Nikolova, Nefize Yalin, Danilo Arnone, Andrea Fagiolini, Allan H Young
Mixed states in bipolar disorder have been neglected, and the data concerning treatment of these conditions have been relatively obscure. To address this, we systematically reviewed published pharmacological treatment data for "mixed states/episodes" in mood disorders, including "with mixed features" in DSM-5. We searched PubMed, MEDLINE, The Cochrane Library, clinicaltrials.gov, and controlled-trials.com (with different combinations of the following keywords: "mixed states/features," "bipolar," "depressive symptoms/bipolar depression," "manic symptoms," "treatment," "DSM-5") through to October 2016...
April 18, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28415008/bipolar-mood-state-reflected-in-cortico-amygdala-resting-state-connectivity-a-cohort-and-longitudinal-study
#10
Roscoe O Brady, Allison Margolis, Grace A Masters, Matcheri Keshavan, Dost Öngür
BACKGROUND: Using resting-state functional magnetic resonance imaging (rsfMRI), we previously compared cohorts of bipolar I subjects in a manic state to those in a euthymic state to identify mood state-specific patterns of cortico-amygdala connectivity. Our results suggested that mania is reflected in the disruption of emotion regulation circuits. We sought to replicate this finding in a group of subjects with bipolar disorder imaged longitudinally across states of mania and euthymia METHODS: We divided our subjects into three groups: 26 subjects imaged in a manic state, 21 subjects imaged in a euthymic state, and 10 subjects imaged longitudinally across both mood states...
March 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28412090/pituitary-gland-in-bipolar-disorder-and-major-depression-evidence-from-structural-mri-studies
#11
G Delvecchio, A C Altamura, J C Soares, P Brambilla
BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28411507/bipolar-mixed-features-results-from-the-comparative-effectiveness-for-bipolar-disorder-bipolar-choice-study
#12
Mauricio Tohen, Alexandra K Gold, Louisa G Sylvia, Rebecca E Montana, Susan L McElroy, Michael E Thase, Dustin J Rabideau, Andrew A Nierenberg, Noreen A Reilly-Harrington, Edward S Friedman, Richard C Shelton, Charles L Bowden, Vivek Singh, Thilo Deckersbach, Terence A Ketter, Joseph R Calabrese, William V Bobo, Melvin G McInnis
BACKGROUND: DSM-5 changed the criteria from DSM-IV for mixed features in mood disorder episodes to include non-overlapping symptoms of depression and hypomania/mania. It is unknown if, by changing these criteria, the same group would qualify for mixed features. We assessed how those meeting DSM-5 criteria for mixed features compare to those meeting DSM-IV criteria. METHODS: We analyzed data from 482 adult bipolar patients in Bipolar CHOICE, a randomized comparative effectiveness trial...
April 5, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28409660/a-randomized-double-blind-placebo-controlled-trial-on-effectiveness-and-safety-of-celecoxib-adjunctive-therapy-in-adolescents-with-acute-bipolar-mania
#13
Seyed Yaser Mousavi, Rasoul Khezri, Mohammad-Ali Karkhaneh-Yousefi, Payam Mohammadinejad, Faezeh Gholamian, Mohammad Reza Mohammadi, Atefeh Zeinoddini, Shahin Akhondzadeh
OBJECTIVE: Recent studies have focused on the role of inflammatory cascades as one of the possible etiologic factors of bipolar disorder. We hypothesize that celecoxib, through its anti-inflammatory properties, may have a therapeutic role in acute bipolar mania. PATIENTS AND METHODS: Forty-two adolescent inpatients with the diagnosis of acute bipolar mania participated in a parallel, randomized, double-blind controlled trial, and 40 patients underwent an 8-week treatment with either celecoxib (100 mg twice daily) or placebo as an adjunctive treatment to lithium and risperidone...
April 14, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28408639/interaction-between-neuronal-calcium-sensor-protein-1-and-lithium-in-pedunculopontine-neurons
#14
Stasia D'Onofrio, James Hyde, Edgar Garcia-Rill
Bipolar disorder is characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). Postmortem studies showed increased expression of neuronal calcium sensor protein 1 (NCS-1) in the brains of some bipolar disorder patients, and reduced or aberrant gamma band activity is present in the same disorder. Lithium (Li(+)) has been shown to effectively treat the mood disturbances in bipolar disorder patients. We previously showed that NCS-1 at low levels increased, and at high levels decreased, gamma oscillations in RAS pedunculopontine neurons (PPN), and that Li(+) decreased these oscillations...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28407229/weight-gain-with-add-on-second-generation-antipsychotics-in-bipolar-disorder-a-naturalistic-study
#15
H Najar, E Joas, M Kardell, E Pålsson, M Landén
OBJECTIVE: Our aim was to investigate the prevalence and magnitude of weight gain in-patients with bipolar disorder when treated with a second-generation antipsychotic as an add-on treatment to a mood stabilizer in routine clinical practice. METHODS: Data were derived from the quality register for bipolar disorder in Sweden (BipoläR). Patients with bipolar disorder who started add-on treatment with a SGA (n = 575) were compared at next yearly follow-up with age and sex matched patients who were only treated with a mood stabilizer (n = 566)...
April 13, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28399092/-the-affective-pathology-in-patients-with-adolescent-bulimia-nervosa
#16
V V Grachev
AIM: To investigate affective pathology in patients with adolescent bulimia nervosa (BN) and to analyze comorbid mutual influences of these clinical entities. MATERIAL AND METHODS: A sample consisted of 52 young female patients, aged from 13.9 to 17.4 years, who simultaneously meet ICD-10 criteria of F50.2 - typical BN and F30-F39 - mood disorders. The Eating Attitudes Test (EAT-26) and the Beck Depression Inventory were used for psychometric assessment. Duration of follow-up ranged from 1 to 7 years...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28398819/distinguishing-bipolar-depression-from-unipolar-depression-in-youth-preliminary-findings
#17
Rasim Somer Diler, Tina R Goldstein, Danella Hafeman, John Merranko, Fangzi Liao, Benjamin I Goldstein, Heather Hower, Mary Kay Gill, Jeffrey Hunt, Shirley Yen, Martin B Keller, David Axelson, Michael Strober, Satish Iyengar, Neal D Ryan, Boris Birmaher
OBJECTIVES: To identify mood symptoms that distinguishes bipolar disorder (BP) depression versus unipolar depression in youth during an acute depressive episode. METHODS: Youth with BP (N = 30) were compared with youth with unipolar depression (N = 59) during an acute depressive episode using the depression and mania items derived from the Schedule for Affective Disorders and Schizophrenia for Children (K-SADS)-Present Version. The results were adjusted for multiple comparisons, and any significant between-group differences in demographic, nonmood comorbid disorders, and psychiatric family history...
February 28, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28398341/the-cacna1c-risk-allele-rs1006737-is-associated-with-age-related-prefrontal-cortical-thinning-in-bipolar-i-disorder
#18
M G Soeiro-de-Souza, B Lafer, R A Moreno, F G Nery, T Chile, K Chaim, C da Costa Leite, R Machado-Vieira, M C G Otaduy, H Vallada
Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood regulation in BD, but the role of this CACNA1C polymorphism in mPFC morphology and brain aging has yet to be elucidated. One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC))...
April 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28396906/the-lausanne-geneva-cohort-study-of-offspring-of-parents-with-mood-disorders-methodology-findings-current-sample-characteristics-and-perspectives
#19
Caroline L Vandeleur, Marie-Pierre F Strippoli, Enrique Castelao, Mehdi Gholam-Rezaee, François Ferrero, Pierre Marquet, Jean-Michel Aubry, Martin Preisig
PURPOSE: Studies focusing on the offspring of affected parents utilize the well-established familial aggregation of mood disorders as a powerful tool for the identification of risk factors, early clinical manifestations, and prodromes of mood disorders in these offspring. The major goals of the Lausanne-Geneva mood cohort study are to: (1) assess the familial aggregation of bipolar and unipolar mood disorders; (2) prospectively identify risk factors for mood disorders as well as their early signs and prodromes; (3) identify their endophenotypes including cognitive features, alterations in brain structure, HPA-axis dysregulation, and abnormalities of the circadian rhythm of activity...
April 10, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28392427/immune-dysregulation-in-offspring-of-a-bipolar-parent-altered-serum-levels-of-immune-growth-factors-at-adolescent-age
#20
G Snijders, E Mesman, H de Wit, A Wijkhuijs, W A Nolen, H A Drexhage, M H J Hillegers
Immune dysregulation plays a role in the vulnerability for mood disorders. Immune growth factors, such as Stem Cell Factor (SCF), Insulin-like Growth Factor-Binding Protein-2 (IGF-BP2), Epidermal Growth Factor (EGF), IL-7 and sCD25 have repeatedly been reported altered in patients with mood disorders. The aim of this study was to investigate levels of these factors in serum of adolescent bipolar offspring, who have a heightened risk for mood disorder development and to also analyze the data combined with previously published data...
April 6, 2017: Brain, Behavior, and Immunity
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