Paraskevi Papadogeorgou, Theodora Boutsikou, Maria Boutsikou, Eleni Pergantou, Aimilia Mantzou, Ioannis Papassotiriou, Zoi Iliodromiti, Rozeta Sokou, Elena Bouza, Marianna Politou, Nikoletta Iacovidou, Serena Valsami
Neonatal sepsis is a life-threatening condition associated with significant morbidity and mortality. Sepsis-induced coagulopathy is a well-recognized entity, signifying the strong cross-talk between inflammation and coagulation. The aim of the present study was to compare the coagulation profile between the acute phase of sepsis and recovery in term and preterm neonates. Additional comparisons to healthy neonates were undertaken. Levels of clotting, anti-clotting factors and ADAMTS-13 (A disintegrin and metalloprotease with thrombospondin type-1 motives), the cleaving protein of von Willebrand factor (VWF), were measured in 16 term and preterm neonates in the acute phase of infection and following recovery, as well as in 18 healthy neonates...
September 26, 2023: Biology