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https://www.readbyqxmd.com/read/28929066/surgical-treatment-of-retrosternal-goitre
#1
Kiera Welman, Richard Heyes, Paras Dalal, Sarah Hough, Marciano Bunalade, Vladimir Anikin
This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected radiologically in 27 (77.2%) patients with deviation in 18 (51...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928871/twisted-gastrulation-bmp-signaling-modulator-1-regulates-papillary-thyroid-cancer-cell-motility-and-proliferation
#2
Shujun Xia, Ri Ji, Yongmin Xu, Xiaofeng Ni, Yijie Dong, Weiwei Zhan
Bone morphogenetic proteins (BMPs) are growth factors that have important functions in cell proliferation, migration and differentiation. To date, BMP pathway activation has been found in multiple human tumors and is associated with enhanced malignant tumor growth and metastasis. BMP activity is tightly regulated by a family of soluble extracellular secreted BMP modulators. Twisted gastrulation BMP signaling modulator 1 (TWSG1) is a direct BMP regulator that is required for the full signaling activity of BMPs...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28924483/thyroidectomy-for-the-treatment-of-graves-thyrotoxicosis-in-thioamide-induced-agranulocytosis-and-sepsis
#3
Colin L Knight, Shamil D Cooray, Jaideep Kulkarni, Michael Borschmann, Mark Kotowicz
A 51 year old man presented with sepsis in the setting of thioamide-induced agranulocytosis. Empiric broad-spectrum antibiotics was followed by directed narrow-spectrum antibiotics, and his neutrophil count recovered with support from granulocyte-colony stimulating factor (G-CSF) analogue transfusions. After a brief period of multi-modal therapy for nine days including potassium iodide (Lugol's iodine), cholestyramine, propanolol and lithium to temper his persisting hyperthyroidism, a total thyroidectomy was performed while thyroid hormone levels remained at thyrotoxic levels...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28924477/a-new-paradigm-in-low-risk-papillary-microcarcinoma-active-surveillance
#4
Alex González Bóssolo, Michelle Mangual Garcia, Paula Jeffs González, Miosotis Garcia, Guillermo Villarmarzo, Jose Hernán Martinez
Classical papillary thyroid microcarcinoma (PTMC) is a variant of papillary thyroid carcinoma (PTC) known to have excellent prognosis. It has a mortality of 0.3%, even in the presence of distance metastasis. The latest American Thyroid Association guidelines state that although lobectomy is acceptable, active surveillance can be considered in the appropriate setting. We present the case of a 37-year-old female with a history of PTMC who underwent surgical management consisting of a total thyroidectomy. Although she has remained disease-free, her quality of life has been greatly affected by the sequelae of this procedure...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#5
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28917091/recovery-from-diabetes-insipidus-and-preservation-of-thyroid-function-after-craniopharyngioma-removal-and-pituitary-stalk-sectioning
#6
Yoshikazu Ogawa, Kuniyasu Niizuma, Teiji Tominaga
OBJECTIVES: Craniopharyngioma is a slow-growing tumor, but long-term tumor control with maintenance of quality of life is sometimes very difficult to achieve, and hypothalamic disturbance should be strictly avoided in the treatment. However, management of the pituitary gland and/or pituitary stalk varies among surgeons and institutions. PATIENTS AND METHODS: This retrospective review identified 44 patients, 24 males and 20 females with craniopharyngiomas who were initially treated by surgery through the extended transsphenoidal approach with pituitary stalk sectioning at a single institute...
September 9, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28915656/patterns-and-clinical-significance-of-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer-patients-with-delphian-lymph-node-metastasis
#7
Guibin Zheng, Hua Zhang, Shaolong Hao, Chengxin Liu, Jie Xu, Jinyao Ning, Guochang Wu, Lixin Jiang, Guojun Li, Haitao Zheng, Xicheng Song
Although the roles of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC) have been previously reported, there are still limited data on correlations of clinicopathologic factors with DLN metastasis and unique patterns of cervical node subsite metastasis in PTC patients with DLN metastasis. We retrospectively reviewed medical records of 320 patients with a diagnosis of PTC who underwent primary surgery. Clinicopathologic features and DLN metastasis patterns were analyzed for predicting extensive cervical lymph node metastasis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912897/genomic-analysis-of-tumor-microenvironment-immune-types-across-14-solid-cancer-types-immunotherapeutic-implications
#8
Yu-Pei Chen, Yu Zhang, Jia-Wei Lv, Ying-Qin Li, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Yan-Ping Mao, Jing-Ping Yun, Na Liu, Jun Ma
We performed a comprehensive immuno-genomic analysis of tumor microenvironment immune types (TMITs), which is classified into four groups based on PD-L1+CD8A or PD-L1+cytolytic activity (CYT) expression, across a broad spectrum of solid tumors in order to help identify patients who will benefit from anti- PD-1/PD-L1 therapy. The mRNA sequencing data from The Cancer Genome Atlas (TCGA) of 14 solid cancer types representing 6,685 tumor samples was analyzed. TMIT was classified only for those tumor types that both PD-L1 and CD8A/CYT could prefict mutation and/or neoantigen number...
2017: Theranostics
https://www.readbyqxmd.com/read/28911724/radioactive-iodine-rai-therapy-for-metastatic-differentiated-thyroid-cancer
#9
REVIEW
Frederik A Verburg, Heribert Hänscheid, Markus Luster
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. It usually has a comparatively benign course. If properly executed, radioiodine therapy can provide an effective treatment of even advanced, metastatic DTC. A major problem in determining the right RAI for a patient with metastatic disease is a comparative lack of evidence. There are no reports on randomized controlled trials in this patient group which can aid us in determining which way to treat which patient. Few non-randomized prospective observational studies have been performed...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911144/randomized-trial-comparing-two-algorithms-for-levothyroxine-dose-adjustment-in-pregnant-women-with-primary-hypothyroidism
#10
Shannon D Sullivan, Erin Downs, Geanina Popoveniuc, Alexander Zeymo, Jacqueline Jonklaas, Kenneth D Burman
Context: Regulation of maternal thyroid hormones during pregnancy is crucial for optimal maternal and fetal outcomes. There are no specific guidelines addressing maternal levothyroxine (LT4) dose adjustments throughout pregnancy. Objective: To compare two LT4 dose-adjustment algorithms in hypothyroid pregnant women. Design: Thirty-three women on stable LT4 doses were recruited at <10 weeks gestation during 38 pregnancies and randomized to one of two dose-adjustment groups...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28910808/detecting-congenital-central-hypothyroidism-by-newborn-screening-difficulty-in-distinguishing-from-congenital-thyroxine-binding-globulin-deficiency
#11
Kara J Connelly, Melinda J Pierce, Cheryl Hanna, Stephen H LaFranchi
BACKGROUND/AIMS: Congenital central hypothyroidism (CH-C) can be detected on newborn screening (NBS) by programs using thyroxine (T4)-reflex thyroid-stimulating hormone (TSH) test approach. CH-C must be distinguished from T4-binding globulin (TBG) deficiency. We sought to determine whether thyroid function tests reliably separate CH-C from TBG deficiency. METHODS: We analyzed NBS and serum free and total T4, T3 resin uptake (T3RU) or TBG, and TSH for infants in the Northwest Regional NBS Program (NWRSP) between the years 2008 and 2015 with either CH-C or TBG deficiency...
September 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28904849/influence-of-socioeconomic-status-comorbidity-and-disability-on-late-stage-cancer-diagnosis
#12
Bo Ram Park, So Young Kim, Dong Wook Shin, Hyung Kook Yang, Jong Hyock Park
OBJECTIVES: Understanding factors affecting advanced stage at diagnosis is vital to improve cancer outcomes and overall survival. We investigated the factors affecting later-stage cancer diagnosis. METHODS: Patients completed self-reported questionnaires. We collected cancer stage data from medical records review. Logistic regression analyses were performed to identify factors associated with later stage cancer at diagnosis by gender. RESULTS: In total, 1,870 cancer patients were included in the study; 55...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28904049/use-of-thyroid-stimulating-hormone-tests-for-identifying-primary-hypothyroidism-in-family-medicine-patients
#13
Elizabeth Birk-Urovitz, M Elisabeth Del Giudice, Christopher Meaney, Karan Grewal
OBJECTIVE: To assess the use of thyroid-stimulating hormone (TSH) tests for identifying primary hypothyroidism in 2 academic family medicine settings. DESIGN: Descriptive study involving a retrospective electronic chart review of family medicine patients who underwent TSH testing. SETTING: Two academic family practice sites: one site is within a tertiary hospital in Toronto, Ont, and the other is within a community hospital in Newmarket, Ont...
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28902465/a-modified-reporting-approach-for-thyroid-fna-in-the-niftp-era-a-1-year-institutional-experience
#14
Jeffrey K Mito, Erik K Alexander, Trevor E Angell, Justine A Barletta, Matthew A Nehs, Edmund S Cibas, Jeffrey F Krane
BACKGROUND: The reclassification of noninvasive follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has created diagnostic and management issues for thyroid fine-needle aspiration (FNA). In response to these challenges, the authors' laboratory adopted a NIFTP policy including 1) stringent criteria (requiring pseudo-inclusions, papillae, and/or psammoma bodies) for a malignant diagnosis of papillary carcinoma to limit false-positive results due to NIFTP and 2) the use of explanatory notes in cases with cytomorphologic features suggestive of possible NIFTP to encourage lobectomy over thyroidectomy...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28901600/ethical-issues-raised-by-thyroid-cancer-overdiagnosis-a-matter-for-public-health
#15
Wendy A Rogers, Wendy L Craig, Vikki A Entwistle
Current practices of identifying and treating small indolent thyroid cancers constitute an important but in some ways unusual form of overdiagnosis. Overdiagnosis refers to diagnoses that generally harm rather than benefit patients, primarily because the diagnosed condition is not a harmful form of disease. Patients who are overdiagnosed with thyroid cancer are harmed by the psycho-social impact of a cancer diagnosis, as well as treatment interventions such partial or total thyroidectomy, lifelong thyroid replacement hormone, monitoring, surgical complications and other side effects...
October 2017: Bioethics
https://www.readbyqxmd.com/read/28898614/-fine-needle-aspiration-of-thyroid-nodules-is-it-worth-repeating
#16
Vera Fernandes, Tânia Pereira, Catarina Eloy
INTRODUCTION: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results. MATERIAL AND METHODS: Retrospective study of the 4800 thyroid nodules fine-needle aspiration held in Instituto de Patologia e Imunologia Molecular da Universidade do Porto between January 1, 2014 and May 2, 2016...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28894814/minimally-invasive-and-remote-access-thyroid-surgery-in-the-era-of-the-2015-american-thyroid-association-guidelines
#17
REVIEW
Jonathon O Russell, Salem I Noureldine, Mai G Al Khadem, Ralph P Tufano
Thyroid surgery has evolved throughout the years from being one of the most dangerous surgeries to becoming one of the safest surgical procedures performed today. Recent technologic innovations have allowed surgeons to remove the thyroid gland from a remote site while avoiding visible neck scars. There are many endoscopic approaches for thyroidectomy. The most common cervical approach is the minimally invasive video-assisted technique developed by Miccoli et al. The robotic transaxillary and axillary breast approaches avoid a neck scar and have been demonstrated to be safe and effective in international populations...
December 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892514/l-thyroxine-modifies-nephrotoxicity-by-regulating-the-apoptotic-pathway-the-possible-role-of-cd38-adp-ribosyl-cyclase-mediated-calcium-mobilization
#18
Tarek El-Hamoly, Dina M El-Sharawy, Marwa S El Refaye, Sahar S Abd El-Rahman
Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the renal cytotoxicity using in vivo and in vitro models. Swiss mice were exposed to gamma radiation (IRR, 6Gy) or treated with cisplatin (CIS, 15 mg/kg, i.p.) for induction of nephrotoxicity. Remarkably, pretreatment with L-TH (1μg/kg) ameliorated the elevated kidney function biomarkers, oxidative stress and protected the renal tissue from the subsequent cellular damage...
2017: PloS One
https://www.readbyqxmd.com/read/28891710/the-use-of-a-thyroid-shield-for-intra-oral-anterior-oblique-occlusal-views-a-risk-based-approach
#19
Mark Worrall, Alison Menhinick, Donald J Thomson
OBJECTIVES: To estimate the radiation dose reduction to the thyroid for an anterior oblique occlusal view from the use of a thyroid shield, compare this to the variation in thyroid dose resulting from differences in examination positioning and discuss the additional considerations associated with the use of a thyroid shield before making a recommendation on their routine use for this examination. METHODS: Doses to the oral mucosa, the salivary glands, the thyroid, the extra-thoracic airways, the oesophagus and the lungs were directly measured for anterior oblique occlusal x-rays of a Rando phantom with and without a thyroid shield using strips of calibrated XRQA Gafchromic film...
September 11, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28891238/excised-larynx-evaluation-of-subthyroid-cartilage-approach-to-medialization-thyroplasty
#20
James D Thompson, Matthew R Hoffman, Austin Scholp, Erin E Devine, Jack J Jiang, Timothy M McCulloch
OBJECTIVES/HYPOTHESIS: To describe an alternative approach to medialization thyroplasty involving dissection underneath the thyroid cartilage with placement of a Gore-Tex implant, and to evaluate its effect on a range of phonatory measures using an excised canine larynx model. STUDY DESIGN: Animal model. METHODS: On each of eight excised canine larynges, the conditions of normal, paralysis, medialization thyroplasty by standard transthyroid cartilage approach, and medialization thyroplasty by experimental subthyroid cartilage approach were performed...
September 11, 2017: Laryngoscope
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