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Thyroid approach

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https://www.readbyqxmd.com/read/28643050/application-of-transoral-continuous-intraoperative-neuromonitoring-in-natural-orifice-transluminal-endoscopic-surgery-for-thyroid-disease-a-preliminary-study
#1
Han-Kun Chen, Chun-Liang Chen, Kuo-Shan Wen, Yi-Feng Lin, Kai-Yuan Lin, Yih-Huei Uen
BACKGROUND: The novel concept of continuous intraoperative neuromonitoring (Cont-IONM) through stimulation of the vagal nerve has been used in thyroidectomies to prevent imminent injury of the recurrent laryngeal nerve (RLN). This article reports on this technology and the results of using transoral Cont-IONM in natural orifice transluminal endoscopic surgery for thyroid disease. METHODS: Cont-IONM of the RLN was achieved through automatic cyclical stimulation of the vagal nerve using a C2 monitor and delta stimulating electrode...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28639242/accuracy-of-fine-needle-cytology-in-histological-prediction-of-papillary-thyroid-carcinoma-variants-a-prospective-study
#2
Anna Cipolletta Campanile, Maria Gabriella Malzone, Nunzia Simona Losito, Gerardo Botti, Maria Grazia Chiofalo, Antongiulio Faggiano, Roberta Siciliano, Annamaria Colao, Luciano Pezzullo, Franco Fulciniti
Fine needle cytology (FNC) is a crucial procedure in the preoperative diagnosis of thyroid tumors. Papillary thyroid carcinoma (PTC), in its classic variant (cPTC), is the most common malignant neoplasm of the thyroid. Several histological variants of PTC have been described, each one with its own characteristics and prognosis. The ability of FNC to identify the variants represents a challenge even for a skilled pathologist. The aim of this study was to evaluate the diagnostic cytological accuracy of FNC in PTC and to look for specific features that could predict the different variants...
June 21, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28639240/approach-to-thyroid-carcinoma-in-pregnancy
#3
Cristina Modesti, Paola Aceto, Lucia Masini, Celestino Pio Lombardi, Rocco Bellantone, Liliana Sollazzi
Thyroid carcinoma is the first cancer found in general population and the second diagnosed during pregnancy following the breast one. Diagnostic and therapeutic approaches to thyroid malignancy in pregnant women pose several and serious issues to the physicians. Even if there is no consensus about the surgical treatment of thyroid carcinomas during pregnancy, a large number of women undergo surgery over the world. The best surgical and anesthesiological treatment should be chosen after reaching a consensus between surgeons, anesthesiologists, obstetrics, and the patients...
June 22, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28638296/ultrasound-guided-percutaneous-cervical-and-upper-thoracic-sympathetic-chain-neuromodulation-for-upper-extremity-complex-regional-pain-syndrome
#4
Samer Narouze, Dmitri Souzdalnitski
BACKGROUND: Complex regional pain syndrome (CRPS) comprises a group of conditions characterized by severe, debilitating pain that is disproportionate to any inciting event and is not distributed in a specific nerve distribution or dermatome. CASE REPORT: A 42-year-old female with a 2-year history of right upper extremity CRPS type I refractory to conventional management underwent an ultrasound-guided and fluoroscopy confirmed percutaneous peripheral nerve stimulation trial with a lead extending from the C6 to the T3 level to cover the cervical and upper thoracic sympathetic chain...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28636673/evaluation-of-molecular-diagnostic-approaches-for-the-detection-of-braf-p-v600e-mutations-in-papillary-thyroid-cancer-clinical-implications
#5
Artur Kowalik, Aldona Kowalska, Agnieszka Walczyk, Renata Chodurska, Janusz Kopczyński, Magdalena Chrapek, Elżbieta Wypiórkiewicz, Małgorzata Chłopek, Liliana Pięciak, Danuta Gąsior-Perczak, Iwona Pałyga, Krzysztof Gruszczyński, Ewelina Nowak, Stanisław Góźdź
Differentiated papillary thyroid cancer (PTC) is the most common cancer of the endocrine system. PTC has a very good prognosis and a high 5 year survival rate; however, some patients are unresponsive to treatment, and their diagnosis eventually results in death. Recent efforts have focused on searching for prognostic and predictive factors that may enable treatment personalization and monitoring across the course of the disease. The presence of the BRAF mutation is considered to contribute to the risk of poor clinical course, according to American Thyroid Association (ATA) recommendations...
2017: PloS One
https://www.readbyqxmd.com/read/28635520/information-for-clinicians-approach-to-the-patient-with-progressive-radioactive-iodine-refractory-thyroid-cancer-when-to-use-systemic-therapy
#6
Maria Cabanillas, David James Terris, Mona Sabra
N/A.
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28634053/using-short-term-bioassays-to-evaluate-the-endocrine-disrupting-capacity-of-the-pesticides-linuron-and-fenoxycarb
#7
Petra Spirhanzlova, Bert De Groef, Freda E Nicholson, Sylvia V H Grommen, Giulia Marras, Anthony Sébillot, Barbara A Demeneix, Sophie Pallud-Mothré, Gregory F Lemkine, Andrew J Tindall, David Du Pasquier
Several short-term whole-organism bioassays based on transgenic aquatic models are now under validation by the OECD (Organization for Economic Co-operation and Development) to become standardized test guidelines for the evaluation of the endocrine activity of substances. Evaluation of the endocrine disrupting capacity of pesticides will be a domain of applicability of these future reference tests. The herbicide linuron and the insecticide fenoxycarb are two chemicals commonly used in agricultural practices...
June 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28633262/intratracheal-thyroid-a-different-approach
#8
Marco Rispoli, Rosario Salvi, Giuseppe La Cerra, Carlo Antonio Leone, Ambra Nicolai, Moana Rossella Nespoli, Antonio Corcione, Salvatore Buono
During embryonic development, the abnormal migration of thyroid tissue may cause ectopic localization of the gland in the intralaryngotracheal space. This case report describes the management of a young patient with a recent diagnosis of asthma. During bronchoscopy, a large mass occupying the tracheal lumen was discovered. After tracheotomy to protect the airway, an incisional biopsy was performed and revealed an intratracheal ectopic thyroid. The deep incisions through the tracheotomy to the base of the lesion allowed colloidal content to leak out of the mass until complete resolution of airway obstruction...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28633125/primary-squamous-cell-carcinoma-of-the-thyroid-case-report-and-systematic-review-of-the-literature
#9
Florian Struller, Moritz Senne, Claudius Falch, Andreas Kirschniak, Alfred Konigsrainer, Sven Muller
BACKGROUND: Primary squamous cell cancer (PSCC) of thyroid is a rare malignancy with poor prognosis. It is mandatory to exclude secondary involvement of the thyroid by panendoscopy, CT-scan and immunohistochemical analysis. As treatment surgery, radiation and rarely chemotherapy is employed. METHODS: A systematic review of the literature was conducted searching medline and embase database using the medical subject headings "primary squamous cell carcinoma of thyroid" and "primary squamous cell cancer of thyroid", for articles published until April 2016 (n=1733)...
June 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28629112/european-demonstration-program-on-the-effect-based-and-chemical-identification-and-monitoring-of-organic-pollutants-in-european-surface-waters
#10
Zuzana Tousova, Peter Oswald, Jaroslav Slobodnik, Ludek Blaha, Melis Muz, Meng Hu, Werner Brack, Martin Krauss, Carolina Di Paolo, Zsolt Tarcai, Thomas-Benjamin Seiler, Henner Hollert, Sanja Koprivica, Marijan Ahel, Jennifer E Schollée, Juliane Hollender, Marc J-F Suter, Anita O Hidasi, Kristin Schirmer, Manoj Sonavane, Selim Ait-Aissa, Nicolas Creusot, Francois Brion, Jean Froment, Ana Catarina Almeida, Kevin Thomas, Knut Erik Tollefsen, Sara Tufi, Xiyu Ouyang, Pim Leonards, Marja Lamoree, Victoria Osorio Torrens, Annemieke Kolkman, Merijn Schriks, Petra Spirhanzlova, Andrew Tindall, Tobias Schulze
Growing concern about the adverse environmental and human health effects of a wide range of micropollutants requires the development of novel tools and approaches to enable holistic monitoring of their occurrence, fate and effects in the aquatic environment. A European-wide demonstration program (EDP) for effect-based monitoring of micropollutants in surface waters was carried out within the Marie Curie Initial Training Network EDA-EMERGE. The main objectives of the EDP were to apply a simplified protocol for effect-directed analysis, to link biological effects to target compounds and to estimate their risk to aquatic biota...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28622647/endocrine-disrupting-activity-of-per-and-polyfluoroalkyl-substances-exploring-combined-approaches-of-ligand-and-structure-based-modeling
#11
Supratik Kar, Maria S Sepúlveda, Kunal Roy, Jerzy Leszczynski
Exposure to perfluorinated and polyfluoroalkyl substances (PFCs/PFASs), endocrine disrupting halogenated pollutants, has been linked to various diseases including thyroid toxicity in human populations across the globe. PFASs can compete with thyroxine (T4) for binding to the human thyroid hormone transport protein transthyretin (TTR) which may lead to reduce thyroid hormone levels leading to endocrine disrupting adverse effects. Environmental fate and endocrine-disrupting activity of PFASs has initiated several research projects, but the amount of experimental data available for these pollutants is limited...
June 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28622037/inhibition-of-the-akt-mtor-pathway-augments-the-anticancer-effects-of-sorafenib-in-thyroid-cancer
#12
Heqing Yi, Xuemei Ye, Bin Long, Ting Ye, Lijun Zhang, Fengqin Yan, Yang Yang, Linfa Li
BACKGROUND: Sorafenib is a multikinase inhibitor that has been approved for the treatment of patients with advanced (131)iodine ((131)I) refractory differentiated thyroid cancer (DTC). However, the progression-free survival of patients with advanced (131)I refractory DTC is short, and most DTC patients eventually acquire resistance to sorafenib. Therefore, new therapeutic strategies need to be developed. MATERIALS AND METHODS: The thyroid cancer cell lines 8505C and FTC133 were treated with sorafenib in the presence or absence of BEZ235 or small interfering RNA (siRNA) directed against AKT...
June 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28620499/intrauterine-death-following-intraamniotic-triiodothyronine-and-thyroxine-therapy-for-fetal-goitrous-hypothyroidism-associated-with-polyhydramnios-and-caused-by-a-thyroglobulin-mutation
#13
Pradeep Vasudevan, Corrina Powell, Adeline K Nicholas, Ian Scudamore, James Greening, Soo-Mi Park, Nadia Schoenmakers
In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. His mother's second pregnancy was complicated by fetal hypothyroid goitre and polyhydramnios, prompting amniotic fluid drainage and intraamniotic therapy (with liothyronine, T3 and levothyroxine, T4)...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28617535/research-on-the-protective-effects-of-antioxidants-on-metabolic-syndrome-induced-by-thyroid-dysfunction
#14
Y Chen, Z Zhou, X-X Li, T Wang
OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615984/papillary-thyroid-microcarcinoma-arising-within-a-mature-ovarian-teratoma-case-report-and-review-of-the-literature
#15
Maria M Pineyro, Jimena Pereda, Pamela Schou, Karina de Los Santos, Soledad de la Peña, Benedicta Caserta, Raul Pisabarro
Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28612612/-molecular-aspects-of-thyroid-tumors-with-emphasis-on-microrna-and-their-clinical-implications
#16
M Ludvíková, I Kholová, D Kalfeřt
BACKGROUND: Central to neoplastic transformation and tumor progression is alteration of the signaling pathways that control cell proliferation and apoptosis. The key mechanisms for this neoplastic process are genetic changes (mutations of cancer-related genes) and recently identified epigenetic changes that involve DNA methylation, chromatin remodeling (which has a profound effect on the control of gene expression), and noncoding, regulatory RNA (notably, microRNA - miRNA). MiRNAs control expression of their target gene post-transcriptionally...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28612210/surgical-approach-to-level-vi-in-papillary-thyroid-carcinoma-an-overview
#17
REVIEW
Carmela De Crea, Marco Raffaelli, Luca Sessa, Celestino Pio Lombardi, Rocco Bellantone
One of the most controversial issues in the treatment of thyroid cancer is the management of the central neck nodes in patients with papillary thyroid carcinoma (PTC). Lymph node involvement is common in patients with PTC and it may negatively affect recurrence rate and, probably, survival. Although therapeutic compartment-oriented central neck dissection is the standard treatment for patients with clinical nodal involvement (cN1) PTC, the role and the extension for elective or prophylactic central neck dissection (PCND) in patients with clinically node negative (cN0) neoplasms remains controversial...
June 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28611949/pseudomalabsorption-of-levothyroxine-a-challenge-for-the-endocrinologist-in-the-treatment-of-hypothyroidism
#18
Nancy Van Wilder, Bert Bravenboer, Sarah Herremans, Nathalie Vanderbruggen, Brigitte Velkeniers
BACKGROUND: Hypothyroidism due to non-compliance with levothyroxine therapy (pseudomalabsorption) is rare. The diagnosis is considered in patients with persistent severe hypothyroidism despite treatment with large doses of levothyroxine. Intestinal malabsorption, drug and dietary interference with levothyroxine absorption and nephrotic syndrome should be excluded. The diagnosis of pseudomalabsorption can be demonstrated by using "an oral 1,000 µg of levothyroxine test" showing a rapid decrease in thyroid-stimulating hormone and increase in thyroxine...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28604619/flavonoids-thyroid-iodide-uptake-and-thyroid-cancer-a-review
#19
REVIEW
Carlos F L Gonçalves, Mariana L de Freitas, Andrea C F Ferreira
Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great part of the differentiated carcinomas, thyrocytes are capable of uptaking iodide. In these cases, the main therapeutic approach includes thyroidectomy followed by ablative therapy with radioiodine. However, in part of the patients, the capacity to concentrate iodide is lost due to down-regulation of the sodium-iodide symporter (NIS), the protein responsible for transporting iodide into the thyrocytes...
June 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28602544/morbidity-of-total-thyroidectomy-for-substernal-goiter-a-series-of-70-patients
#20
N Tabchouri, Z Anil, F Marques, N Michot, P Dumont, V Arnault, L De Calan
Total thyroidectomy for substernal goiter occasionally requires a sternotomy associated with a cervical incision. We sought to analyze the postoperative complications of thyroidectomy for substernal goiters in our center and more precisely the complications related to the sternotomy. All patients who underwent total thyroidectomy for substernal goiter in our center between 2007 and 2016 were reviewed retrospectively. Patients with combined cervical incision and sternotomy (ST group, n=16) were compared to those with cervical incision alone (CT group, n=54), with regard to postoperative complications...
June 8, 2017: Journal of Visceral Surgery
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