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JOURNAL ARTICLE
Jianmin Zhao, Yanlei Li, Yanlin Zhang, Xue Mei, Wei Liu, Yinghong Li
Langerhans cell histiocytosis (LCH) of the stomach is rare. Moreover, it is usually found in pediatric patients with systemic diseases and may be associated with a poor prognosis. Solitary gastric LCH in adults is extremely rare and is often misdiagnosed or missed. The aim of our study was to review cases of gastric LCH and explore the characteristics of the disease further. A retrospective study of all patients admitted with solitary gastric LCH was conducted between 2013 and 2023. Clinical manifestations, endoscopic and pathological features, immunophenotypes, and molecular changes were collected from medical records...
April 23, 2024: Journal of Hematopathology
#22
JOURNAL ARTICLE
Hala M Zeidan, Neveen Hassan Nashaat, Maha Hemimi, Adel F Hashish, Amal Elsaeid, Nagwa Abd El-Ghaffar, Suzette I Helal, Nagwa A Meguid
ADHD has huge knowledge gaps concerning its etiology. MicroRNAs (miRNAs) provide promising diagnostic biomarkers of human pathophysiology and may be a novel therapeutic option. The aim was to investigate the levels of miR-34c-3p, miR-155, miR-138-1, miR-296-5p, and plasma brain-derived neurotrophic factor (BDNF) in a group of children with ADHD compared to neurotypicals and to explore correlations between these measures and some clinical data. The participants were children with ADHD in Group I (N = 41; age: 8...
April 23, 2024: Journal of Molecular Neuroscience: MN
#23
JOURNAL ARTICLE
Nupur Bhatt, Lydia Pan, Tom Ben-Dov, Scott Rickert
BACKGROUND: Myofibromas are rare mesenchymal tumors with a predilection for the head, neck, and oral cavity. Primarily affecting infants and young children, these tumors typically manifest as superficial painless nodules. Diagnosis is confirmed through histopathological examination of a biopsy, revealing nodules characterized by spindle cell proliferation. To our knowledge, only two cases of pinna myofibroma have been previously reported in the literature. CASE PRESENTATION: Here, we present the case of a three-year-old male who developed a myofibroma of the left auricle following trauma to the area one year earlier...
April 23, 2024: Surgical Case Reports
#24
REVIEW
Oksana Andreevna Golovina, Anna Vasilievna Torgashina, Vadim Romanovich Gorodetskiy, Evgenia Vladimirovna Sockol, Elena Georgievna Sagina
The frequency of antibodies to Ku varies in various autoimmune diseases. In 2019, Spielmann et al. identified two types of anti-Ku syndrome based on a hierarchical clustering analysis. Sjögren's syndrome occurs both in the first type of anti-Ku syndrome and in the second type. Despite the fact that increased tissue expression of Ku proteins was noted in lymphocytic cells with focal sialoadenitis of the minor salivary glands in patients with primary Sjogren's syndrome, only 49 cases of a combination of anti-Ku antibodies and manifestations of Sjogren's syndrome have been described in the literature...
April 23, 2024: Clinical Rheumatology
#25
JOURNAL ARTICLE
Ann-Kristin Struckmeier, Mayte Buchbender, Abbas Agaimy, Marco Kesting
OBJECTIVES: Effective management of neck in oral squamous cell carcinoma (OSCC) is pivotal for oncological outcomes. Although consensus exists for ipsilateral neck dissection (ND), the necessity for contralateral ND remains controversial. This study aimed to assess the prevalence and implications of bilateral/solely contralateral (B/SC) lymph node metastases (LNMs) to determine the need for contralateral elective ND. Additionally, it examined the prevalence and implications of occult B/SC metastases...
April 23, 2024: Clinical Oral Investigations
#26
COMPARATIVE STUDY
Chung-You Tsai, Shang-Ju Hsieh, Hung-Hsiang Huang, Juinn-Horng Deng, Yi-You Huang, Pai-Yu Cheng
PURPOSE: To compare ChatGPT-4 and ChatGPT-3.5's performance on Taiwan urology board examination (TUBE), focusing on answer accuracy, explanation consistency, and uncertainty management tactics to minimize score penalties from incorrect responses across 12 urology domains. METHODS: 450 multiple-choice questions from TUBE(2020-2022) were presented to two models. Three urologists assessed correctness and consistency of each response. Accuracy quantifies correct answers; consistency assesses logic and coherence in explanations out of total responses, alongside a penalty reduction experiment with prompt variations...
April 23, 2024: World Journal of Urology
#27
REVIEW
Junji Hatakeyama, Kensuke Nakamura, Hidenori Sumita, Daisuke Kawakami, Nobuto Nakanishi, Shizuka Kashiwagi, Keibun Liu, Yutaka Kondo
The importance of ongoing post-discharge follow-up to prevent functional impairment in patients discharged from intensive care units (ICUs) is being increasingly recognized. Therefore, we conducted a scoping review, which included existing ICU follow-up clinic methodologies using the CENTRAL, MEDLINE, and CINAHL databases from their inception to December 2022. Data were examined for country or region, outpatient name, location, opening days, lead profession, eligible patients, timing of the follow-up, and assessment tools...
April 23, 2024: Journal of Anesthesia
#28
JOURNAL ARTICLE
Nicolai Oetter, Jonas Pröll, Matti Sievert, Miguel Goncalves, Maximilian Rohde, Christopher-Philipp Nobis, Christian Knipfer, Marc Aubreville, Zhaoya Pan, Katharina Breininger, Andreas Maier, Marco Kesting, Florian Stelzle
OBJECTIVES: Confocal laser endomicroscopy (CLE) is an optical method that enables microscopic visualization of oral mucosa. Previous studies have shown that it is possible to differentiate between physiological and malignant oral mucosa. However, differences in mucosal architecture were not taken into account. The objective was to map the different oral mucosal morphologies and to establish a "CLE map" of physiological mucosa as baseline for further application of this powerful technology...
April 23, 2024: Clinical Oral Investigations
#29
JOURNAL ARTICLE
JingWen Li, Wai Ying Kot, Colman Patrick McGrath, Bik Wan Amy Chan, Joshua Wing Kei Ho, Li Wu Zheng
BACKGROUND: The objective of this study is to examine the application of AI algorithms in detecting OPMD and oral cancerous lesions, and to evaluate the accuracy variations among different imaging tools employed in these diagnostic processes. MATERIALS AND METHODS: A systematic search was conducted in four databases: Embase, Web of Science, PubMed, and Scopus. The inclusion criteria included studies using machine learning algorithms to provide diagnostic information on specific oral lesions, prospective or retrospective design, and inclusion of OPMD...
April 23, 2024: International Journal of Surgery
#30
JOURNAL ARTICLE
Linda Christie Andrea, Susanne Wulff Svendsen, Poul Frost, Kate Smidt, John Gelineck, David Høyrup Christiansen, Søren Rasmussen Deutch, Torben Bæk Hansen, Jens Peder Haahr, Annett Dalbøge
OBJECTIVE: Aims were to (i) report prevalence and (ii) evaluate reliability of the radiographic findings in examinations of patients suspected of subacromial impingement syndrome (SIS), performed before a patient's first consultation at orthopaedic department. MATERIALS AND METHODS: This cross-sectional study examined radiographs from 850 patients, age 18 to 63 years, referred to orthopaedic clinic on suspicion of SIS. Prevalence (%) of radiographic findings were registered...
April 23, 2024: Skeletal Radiology
#31
REVIEW
Diego Morales-Roccuzzo, Mohammadmahdi Sabahi, Michal Obrzut, Edinson Najera, David Monterroso-Cohen, Shadi Bsat, Badih Adada, Hamid Borghei-Razavi
PURPOSE: This article presents a comprehensive exploration of neurovascular anatomy of the encephalon, focusing specifically on the intricate network within the posterior circulation and the posterior fossa anatomy; enhancing understanding of its dynamics, essential for practitioners in neurosurgery and neurology areas. METHOD: A profound literature review was conducted by searching the PubMed and Google Scholar databases using main keywords related to neurovascular anatomy...
April 23, 2024: Surgical and Radiologic Anatomy: SRA
#32
REVIEW
Şerife Ayten, Saniye Bilici
PURPOSE OF REVIEW: The gut microbiota plays a crucial role in the pathogenesis of neuroinflammation and Alzheimer's and Parkinson's diseases. One of the main modulators of the gut microbiota is the diet, which directly influences host homeostasis and biological processes. Some dietary patterns can affect neurodegenerative diseases' progression through gut microbiota composition, gut permeability, and the synthesis and secretion of microbial-derived neurotrophic factors and neurotransmitters...
April 23, 2024: Current Nutrition Reports
#33
JOURNAL ARTICLE
Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder.
Erica N Grodin, Dylan Kirsch, Malia Belnap, Lara A Ray
BACKGROUND: Alcohol use disorder (AUD) and stress influence overlapping neural circuits in the brain. The literature is mixed regarding the presence of sex differences in the neural response to acute stressors, and this issue has not been examined in individuals with AUD. We validated a stress functional magnetic resonance imaging (fMRI) paradigm in individuals with AUD and tested for sex differences. METHODS: Twenty-five treatment-seeking individuals with AUD (15M/10F) were recruited to participate in the neuroimaging study linked to a clinical trial of ibudilast (NCT03594435)...
April 23, 2024: Alcohol Clin Exp Res (Hoboken)
#34
JOURNAL ARTICLE
Laura A Siminoff, Maureen Wilson-Genderson, Marcin Chwistek, Maria Thomson
INTRODUCTION: The objective of this study was to comprehensively understand the burden experienced by caregivers (CGs) providing home-based, end-of-life care to patients with cancer. We examined the relationship between objective and subjective burden including whether and how burden changes over time. METHODS: A case series of terminal cancer patient-caregiver dyads (n = 223) were recruited from oncology clinics and followed for 12 months or until patient death...
April 23, 2024: Oncologist
#35
JOURNAL ARTICLE
Song-Bin Guo, Le-Sheng Hu, Wei-Juan Huang, Zhen-Zhong Zhou, Hui-Yan Luo, Xiao-Peng Tian
BACKGROUND: Neoadjuvant and adjuvant immunotherapies for cancer have evolved through a series of remarkable and critical research advances; however, addressing their similarities and differences is imperative in clinical practice. Therefore, this study aimed to examine their similarities and differences from the perspective of informatics analysis. METHODS: This cross-sectional study retrospectively analyzed extensive relevant studies published between 2014 and 2023 using stringent search criteria, excluding non-peer-reviewed and non-English documents...
April 23, 2024: International Journal of Surgery
#36
JOURNAL ARTICLE
Xinxin Zhang, Yichen Wang, Xiaojuan Xu, Jie Zhang, Yuying Sun, Mancang Hu, Sicong Wang, Yi Li, Yan Chen, Xinming Zhao
PURPOSE: To investigate the influence of deep learning reconstruction (DLR) on bladder MRI, specifically examination time, image quality, and diagnostic performance of vesical imaging reporting and data system (VI-RADS) within a prospective clinical cohort. METHODS: Seventy participants with bladder cancer who underwent MRI between August 2022 and February 2023 with a protocol containing standard T2-weighted imaging (T2WIS ), standard diffusion-weighted imaging (DWIS ), fast T2WI with DLR (T2WIDL ), and fast DWI with DLR (DWIDL ) were enrolled in this prospective study...
April 23, 2024: Abdominal Radiology
#37
JOURNAL ARTICLE
Zhenglin Pan, Na Qi, Qingyuan Meng, Boyang Pan, Tao Feng, Jun Zhao, Nan-Jie Gong
BACKGROUND: The application of deep learning methods in rapid bone scintigraphy is increasingly promising for minimizing the duration of SPECT examinations. Recent works showed several deep learning models based on simulated data for the synthesis of high-count bone scintigraphy images from low-count counterparts. Few studies have been conducted and validated on real clinical pairs due to the misalignment inherent in multiple scan procedures. PURPOSE: To generate high quality whole-body bone images from 2× and 3× fast scans using deep learning based enhancement method...
April 23, 2024: Medical Physics
#38
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#39
JOURNAL ARTICLE
State of the Science: Prolonged exposure therapy for the treatment of posttraumatic stress disorder.
Carmen P McLean, Edna B Foa
Prolonged exposure therapy (PE) is a well-established first-line treatment for posttraumatic stress disorder (PTSD) that is based on emotional processing theory. PE has been rigorously evaluated and tested in a large number of clinical trials in many countries covering a wide range of trauma populations. In this review, we summarize the evidence base supporting the efficacy of PE across populations, including adults with sexual assault-related PTSD and mixed trauma-related PTSD, military populations, and adolescents...
April 23, 2024: Journal of Traumatic Stress
#40
JOURNAL ARTICLE
Kathryn A Six, Inmaculada B Aban, Gabriel M Daniels, Julie Wolfson, Elizabeth A Beierle, Matthew A Kutny, Jeffrey Lebensburger, Ana C Xavier
Lymphadenopathy is a common reason for referral to a subspecialist, which may result in significant anxiety for parents. Understanding which patients require a subspecialty referral for lymphadenopathy is key to streamlining health care utilization for this common clinical entity. This is an IRB-approved retrospective study examining pediatric patients consecutively referred to pediatric hematology oncology, otolaryngology, or surgery for lymphadenopathy from 2012 to 2021 at a free-standing tertiary-care children's hospital...
April 23, 2024: Journal of Pediatric Hematology/oncology
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