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https://www.readbyqxmd.com/read/29917272/enhancing-the-effects-of-exfoliated-carbon-nanofibers-using-bone-morphogenetic-protein-in-a-rat-spinal-fusion-model
#1
Naoki Notani, Masashi Miyazaki, Masahiro Toyoda, Shozo Kanezaki, Toshinobu Ishihara, Hiroshi Tsumura
Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs using bone morphogenetic proteins (BMPs) and examined their feasibility and safety in clinical applications using a rat spinal fusion model. Group I (n = 15) animals were implanted with the control carrier; Group II (n = 16) animals were implanted with carrier containing 1 μg ExCNFs; Group III (n = 16) animals were implanted with carrier containing 1 μg recombinant human (rh) BMP-2; and Group IV (n = 17) animals were implanted with carrier containing 1 μg rhBMP-2 and 1 μg ExCNFs...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917245/intranasal-oxytocin-does-not-modulate-responses-to-alcohol-in-social-drinkers
#2
Ashley Vena, Andrea King, Royce Lee, Harriet de Wit
INTRODUCTION: Preclinical and clinical evidence suggest that the neuropeptide oxytocin may be of value in treating alcohol use disorder, either by reducing the rewarding effects of alcohol or reducing negative affect induced by alcohol withdrawal. However, the effect of a single dose of oxytocin on subjective and psychomotor responses to alcohol in social drinkers is not known. METHODS: The present study examined the effect of intranasal oxytocin on subjective, behavioral, and physiological responses to a moderate dose of alcohol (0...
June 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29917207/impact-of-patients-nutritional-status-on-major-surgery-outcome
#3
E V Mignini, E Scarpellini, E Rinninella, E Lattanzi, M V Valeri, N Clementi, L Abenavoli, A Gasbarrini, C Rasetti, P Santori
OBJECTIVE: Surgery is a major stress factor that activates several inflammatory and catabolic pathways in man. An appropriate nutritional status allows the body to react properly to this stressor and recover in a faster and more efficient manner. On the other hand, malnutrition is related to a worse surgery outcome and to a higher prevalence of comorbidities and mortality. The aims of this study were to evaluate the nutritional status of patients undergoing major surgery and investigate the potential correlation between malnutrition and surgical outcomes...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917192/mir-4299-suppresses-non-small-cell-lung-cancer-cell-proliferation-migration-and-invasion-through-modulating-pten-akt-pi3k-pathway
#4
W-B Yang, W-P Zhang, J-L Shi, J-W Wang
OBJECTIVE: The aim of the present study was to investigate clinical significances and biological roles of miR-4299 in non-small cell lung cancer (NSCLC) PATIENTS AND METHODS: Expression of miR-4299 in NSCLC tissues and matched non-tumor tissues was determined by quantitative real-time PCR (qRT-PCR). The correlations between miR-4299 expression and clinicopathological characteristics and prognosis were also analyzed. MTT assay and Transwell assay were performed to determine the proliferation, migration and invasion...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917186/long-non-coding-rna-fezf1-as1-is-up-regulated-and-associated-with-poor-prognosis-in-patients-with-cervical-cancer
#5
H-H Zhang, A-H Li
OBJECTIVE: Long noncoding RNA FEZF1-AS1 (FEZF1-AS1) has been showed to involve in a variety of cancers. However, its function and clinical significance in cervical cancer (CC) have not been investigated. The aim of this study was to explore the prognostic value of FEZF1-AS1 in CC patients. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the expression level of FEZF1-AS1 in CC specimens and adjacent normal cervical tissues...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917160/the-relationship-between-healthcare-workers-attachment-styles-and-patient-outcomes-a-systematic-review
#6
Chizu Mimura, Ian J Norman
Purpose: To examine whether attachment styles of healthcare workers influence the quality of their relationships with patients, or impact patients' health outcomes. Data source: Literature database searches on the CINAHL, Cochrane Library, Embase, MEDLINE and PsyCinfo, and hand searching of reference lists of the retained articles. Study selection: Original empirical studies reporting an analysis of the relationship of interest were selected for review...
June 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917093/noninvasive-thermal-evaluation-of-ventriculoperitoneal-shunt-patency-and-cerebrospinal-fluid-flow-using-a-flow-enhancing-device
#7
Mustafa Q Hameed, David Zurakowski, Mark R Proctor, Scellig S D Stone, Benjamin C Warf, Edward R Smith, Liliana C Goumnerova, Marek Swoboda, Tomer Anor, Joseph R Madsen
BACKGROUND: While a noninvasive flow determination would be desirable in the diagnosis of cerebrospinal fluid shunt malfunction, existing studies have not yet defined a role for thermal flow detection. OBJECTIVE: To evaluate a revised test protocol using a micropumper designed to transiently enhance flow during thermal testing to determine whether thermal detection of flow is associated with progression to shunt revision surgery. METHODS: Eighty-two unique tests were performed in 71 shunts...
June 16, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29917091/gender-differences-in-negative-affect-during-acute-tobacco-abstinence-differ-between-african-american-and-white-adult-cigarette-smokers
#8
Raina D Pang, Mariel S Bello, Madalyn M Liautaud, Andrea H Weinberger, Adam M Leventhal
Introduction: Prior studies have found heightened negative affect following tobacco abstinence in women compared to men. However, experimental work addressing whether these findings generalize across racial groups is scarce. The current study investigated whether race (Non-Hispanic White vs. Non-Hispanic African American) moderated gender differences in abstinence-induced negative affect and smoking behavior. Methods: Data were collected from 2010 to 2017 from two separate laboratory studies investigating experimentally manipulated tobacco abstinence...
June 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29917080/association-between-cortical-gaba-and-loudness-dependence-of-auditory-evoked-potentials-ldaep-in-humans
#9
Christine Wyss, Desmond H Y Tse, Frank Boers, Jon Shah N, Irene Neuner, Wolfram Kawohl
Loudness dependence of auditory evoked potentials (LDAEP) is a widely used electroencephalography (EEG) based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure...
June 15, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29917073/detection-of-distant-interval-metastases-after-neoadjuvant-therapy-for-esophageal-cancer-with-18f-fdg-pet-ct-a-systematic-review-and-meta-analysis
#10
T E Kroese, L Goense, R van Hillegersberg, B de Keizer, S Mook, J P Ruurda, P S N van Rossum
Restaging after neoadjuvant therapy aims to reduce the number of patients undergoing esophagectomy in case of distant (interval) metastases. The aim of this study is to systematically review and meta-analyze the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) and 18F-FDG PET/CT for the detection of distant interval metastases after neoadjuvant therapy in patients with esophageal cancer. PubMed/MEDLINE, Embase, and the Cochrane library were systematically searched...
June 16, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29917035/how-can-nanotechnology-help-the-fight-against-breast-cancer
#11
REVIEW
Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco, Lucia Gemma Delogu
In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis...
June 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29917011/pigmented-villonodular-synovitis-of-the-knee-an-underappreciated-source-of-pain-in-children-and-adolescents
#12
Samuel Clifton Willimon, Michael T Busch, Crystal A Perkins
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described in adults. The purpose of this study is to describe the presentation and management of a large single-center series of pediatric patients with PVNS of the knee. METHODS: A retrospective review was performed of consecutive pediatric patients treated for PVNS at a single institution from 2001 to 2016. Inclusion criteria were patients below 20 years of age with surgical treatment of histologically proven PVNS of the knee...
June 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29916999/evaluation-of-ocular-surface-disease-in-patients-with-glaucoma-clinical-parameters-self-report-assessment-and-keratograph-analysis
#13
Renata C Portela, Nikoly T Fares, Lilian F Machado, Amanda F São Leão, Denise de Freitas, Augusto Paranhos, Tiago S Prata, Carolina P B Gracitelli
PURPOSE: To assess ocular surface disease (OSD) in glaucoma using clinical parameters, self-report assessment and keratograph analysis. METHODS: A total of 30 glaucoma patients and 27 subjects with cataracts (control group) were enrolled in the study. Only glaucoma patients who were using at least 1 topical intraocular pressure (IOP)-lowering medication were included. An ophthalmological examination was performed, including tear break-up time, assessment of conjunctival hyperemia and keratitis, and completion of the Ocular Surface Disease Index (OSDI) questionnaire...
June 18, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29916957/regional-differences-in-diffuse-idiopathic-skeletal-hyperostosis-a-retrospective-cohort-study-from-sweden-and-japan
#14
Atsuhiko Hirasawa, Yohan Robinson, Claes Olerud, Norimitsu Wakao, Mitsuhiro Kamiya, Kenta Murotani, Masataka Deie
STUDY DESIGN: We retrospectively reviewed computed tomography (CT) records of patients in Japan and Sweden, which are both aging populations. OBJECTIVE: To researche the influence of ethnicity and region on diffuse idiopathic skeletal hyperostosis (DISH) prevalence. SUMMARY OF BACKGROUND DATA: DISH can complicate non-surgical treatment of spinal fractures and often requires surgical intervention. We previously reported a prevalence of DISH in Japan that was higher than that reported in other studies...
June 18, 2018: Spine
https://www.readbyqxmd.com/read/29916948/prospective-evaluation-of-the-espghan-guidelines-for-diagnosis-of-coeliac-disease-in-new-zealand-children
#15
Jonathan Bishop, Peter Reed, Paul Austin, Miriam Hurst, Rohan Ameratunga, Alyson Craigie, Jeannette McFarlane, Simon E Chin, Stephen M Mouat, Helen M Evans
OBJECTIVE: The 2012 European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guideline for diagnosis of celiac disease (CD) questioned the requirement for intestinal biopsy to confirm the diagnosis. The guideline recommends that, in symptomatic patients with consistent HLA subtypes, the diagnostic accuracy of strongly positive serology is sufficient to confirm the diagnosis. We prospectively assessed these guidelines in a "real-life" clinical setting...
June 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29916927/laboratory-tests-for-diagnosis-of-chronic-periprosthetic-joint-infection-can-help-predict-outcomes-of-two-stage-exchange
#16
Maureen K Dwyer, Christopher Damsgaard, Jason Wadibia, Gordon Wong, Damien Lazar, Eric Smith, Carl Talmo, Hany Bedair
BACKGROUND: Although 2-stage exchange arthroplasty is the most effective treatment among available strategies for managing chronic periprosthetic joint infection (PJI), rates of its success vary greatly. The purpose of our study was to examine whether objective measurements collected at the time of the diagnosis of PJI could be used to identify patients at risk of failure of 2-stage exchange. METHODS: We identified 205 patients across 4 institutions who underwent 2-stage exchange arthroplasty for the treatment of PJI following total hip or total knee arthroplasty...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916857/serum-lactate-level-accurately-predicts-mortality-in-critically-ill-patients-with-cirrhosis-with-acute-kidney-injury
#17
Dan-Qin Sun, Chen-Fei Zheng, Feng-Bin Lu, Sven Van Poucke, Xiao-Ming Chen, Yong-Ping Chen, Lai Zhang, Ming-Hua Zheng
BACKGROUND AND AIM: Serum lactate levels are routinely measured in critically ill patients with cirrhosis, and hyperlactatemia is a common finding, but its prognostic value remains controversial. Our aim was to examine whether serum lactate level could be used as a predictor of outcome in critically ill patients with cirrhosis (CICP) with acute kidney injury (AKI). PATIENTS AND METHODS: In this study, we included 480 consecutive patients with cirrhosis admitted to ICU, complicated with AKI, and were followed up for 365 days...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29916794/perceptions-of-resilience-and-physical-health-symptom-improvement-following-post-disaster-integrated-health-services
#18
Howard J Osofsky, Carl F Weems, Rebecca A Graham, Joy D Osofsky, Tonya C Hansel, Lucy S King
OBJECTIVE: Theorists and researchers have linked resilience with a host of positive psychological and physical health outcomes. This paper examines perceptions of resilience and physical health symptoms in a sample of individuals exposed to multiple community disasters following involvement in integrated mental health services. METHODS: A multiwave naturalistic design was used to follow 762 adult clinic patients (72% female; 28% minority status), ages 18-92 years (mean age=40 years), who were evaluated for resilience and physical health symptoms prior to receiving services and at 1, 3, and 6 months' follow-up...
June 19, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29916776/acute-appendicitis-a-meta-analysis-of-the-diagnostic-accuracy-of-us-ct-and-mri-as-second-line-imaging-tests-after-an-initial-us
#19
Kevin A Eng, Aryan Abadeh, Carolina Ligocki, Yvonne K Lee, Rahim Moineddin, Thomasin Adams-Webber, Suzanne Schuh, Andrea S Doria
Purpose To evaluate the sensitivity, specificity, and diagnostic odds ratios of US, CT, and MRI as second-line imaging modalities after initial US for assessing acute appendicitis in children and adults. Materials and Methods A literature search was conducted in Medline and Embase to identify articles that used surgery or histopathologic examination alone or in combination with clinical follow-up or chart review to evaluate the diagnostic accuracy of second-line imaging modalities. The quality of articles was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2 and the Standards for Reporting of Diagnostic Accuracy tools...
June 19, 2018: Radiology
https://www.readbyqxmd.com/read/29916756/association-of-risk-factors-with-temporomandibular-disorders-in-the-northern-finland-birth-cohort-1966
#20
Päivi Jussila, Jarno Knuutila, Sampo Salmela, Ritva Näpänkangas, Jari Päkkilä, Pertti Pirttiniemi, Aune Raustia
OBJECTIVE: To investigate the association between risk factors and pain-related symptoms and clinical signs of temporomandibular disorders (TMD) in Northern Finland Birth Cohort (NFBC) 1966. MATERIAL AND METHODS: A total of 1962 subjects (1050 women, 912 men) attended the follow-up study. The questionnaires included the subjects' background information concerning living conditions and general health, socioeconomic factors, and dental health. The clinical examination was performed using the modified protocol of Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) presented at the International Association for Dental Research (IADR) Conference in 2010...
June 19, 2018: Acta Odontologica Scandinavica
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