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https://www.readbyqxmd.com/read/28432979/the-reality-of-economics-for-oncologists
#1
REVIEW
David Taylor
This article outlines the historical development of health economics and its present role in oncology related health technology assessments (HTAs). Despite concerns about the prices and immediate costs of new anticancer medicines for indications such as breast cancer overall spending on such treatments is affordable and offers long term value for money in countries such as the US, Canada and those of Western Europe. Oncologists wishing to protect the interests of current and future patients with both advanced and earlier stage cancers may be regarded as having a responsibility to understand the nature of health economic evaluations, and to be actively involved in decisions affecting access to current treatments and future levels of investment in incrementally improving therapies...
April 19, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28432950/effects-of-chlortetracycline-and-copper-on-tetracyclines-and-copper-resistance-genes-and-microbial-community-during-swine-manure-anaerobic-digestion
#2
Rui Wang, Meixue Chen, Feng Feng, Junya Zhang, Qianwen Sui, Juan Tong, Yuansong Wei, Dongbin Wei
As antibiotic and heavy metals are over used in the livestock industry, animal manure is a reservoir of antibiotic resistance genes (ARGs). Anaerobic digestion has been reported to have the potential to reduce ARGs. However, few studies investigated whether reduction of ARGs would be affected by different external pressures including antibiotics and heavy metals during anaerobic digestion. The purpose of this study was thus to investigate effects of both chlortetracycline (CTC) and Cu on reduction of ARGs, heavy metal resistance genes (HMRGs) and mobile genetic elements (MGEs) during the swine manure anaerobic digestion...
March 25, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28432917/chiral-recognition-of-phenylglycinol-enantiomers-based-on-n-acetyl-l-cysteine-capped-cdte-quantum-dots-in-the-presence-of-ag
#3
Yuan Guo, Xiaoqing Zeng, Haiyan Yuan, Yunmei Huang, Yanmei Zhao, Huan Wu, Jidong Yang
In this study, a novel method for chiral recognition of phenylglycinol (PG) enantiomers was proposed. Firstly, water-soluble N-acetyl-l-cysteine (NALC)-capped CdTe quantum dots (QDs) were synthesized and experiment showed that the fluorescence intensity of the reaction system slightly enhancement when added PG enantiomers to NALC-capped CdTe quantum dots (QDs), but the R-PG and S-PG could not be distinguished. Secondly, when there was Ag(+) presence in the reaction system, the experiment result was extremely interesting, the PG enantiomers cloud make NALC-capped CdTe QDs produce different fluorescence signal, in which the fluorescence of S-PG+Ag(+)+NALC-CdTe system was significantly enhanced, and the fluorescence of R-PG+Ag(+)+NALC-CdTe system was markedly decreased...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28432874/delayed-changes-in-auditory-status-in-cochlear-implant-users-with-preserved-acoustic-hearing
#4
Rachel A Scheperle, Viral D Tejani, Julia K Omtvedt, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Jacob J Oleson, Marie V Ozanne
This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28432829/trabecular-mapping-leveraging-geometric-morphometrics-for-analyses-of-trabecular-structure
#5
Adam D Sylvester, Claire E Terhune
OBJECTIVES: Trabecular microstructure of limb bone epiphyses has been used to elucidate the relationship between skeletal form and behavior among mammals. Such studies have often relied on the analysis of a single volume of interest (VOI). Here we present a method for evaluating variation in bone microstructure across articular surfaces by leveraging sliding semilandmarks. METHODS: Two samples were used to demonstrate the proposed methodology and test the hypothesis that microstructural variables are homogeneously distributed: tali from two ape genera (Pan and Pongo, n = 9) and modern human distal femora (n = 10)...
April 22, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28432768/the-fate-of-recently-fixed-carbon-after-drought-release-towards-unravelling-c-storage-regulation-in-tilia-platyphyllos-and-pinus-sylvestris
#6
Lucía Galiano Pérez, Galina Timofeeva, Matthias Saurer, Rolf Siegwolf, Jordi Martínez-Vilalta, Robert Hommel, Arthur Gessler
Carbon reserves are important for maintaining tree function during and after stress. Increasing tree mortality driven by drought globally has renewed the interest in how plants regulate allocation of recently fixed C to reserve formation. Three year-old seedlings of two species (Tilia platyphyllos, Pinus sylvestris) were exposed to two intensities of experimental drought during ~ 10 weeks and (13) C pulse labelling was subsequently applied with rewetting. Tracking the (13) C-label across different organs and C compounds (soluble sugars, starch, myo-inositol, lipids and cellulose), together with the monitoring of gas exchange and C mass balances over time, allowed for the identification of variations in C allocation priorities and tree C balances that are associated to drought effects and subsequent drought release...
April 22, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28432767/categorical-learning-revealed-in-activity-pattern-of-left-fusiform-cortex
#7
Jessica E Goold, Ming Meng
The brain is organized such that it encodes and maintains category information about thousands of objects. However, how learning shapes these neural representations of object categories is unknown. The present study focuses on faces, examining whether: (1) Enhanced categorical discrimination or (2) Feature analysis enhances face/non-face categorization in the brain. Stimuli ranged from non-faces to faces with two-toned Mooney images used for testing and gray-scale images used for training. The stimulus set was specifically chosen because it has a true categorical boundary between faces and non-faces but the stimuli surrounding that boundary have very similar features, making the boundary harder to learn...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28432745/safety-of-sitagliptin-in-patients-with-type-2-diabetes-and-chronic-kidney-disease-outcomes-from-tecos
#8
Samuel S Engel, Shailaja Suryawanshi, Susanna R Stevens, Robert G Josse, Jan H Cornel, Neli Jakuboniene, Axel Riefflin, Tsvetalina Tankova, Julio Wainstein, Eric D Peterson, Rury R Holman
AIMS: To characterize the incidence of diabetes-associated complications and assess the safety of sitagliptin in participants with chronic kidney disease (CKD) in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). MATERIALS AND METHODS: For participants with baseline eGFR measurements (n = 14,528), baseline characteristics and safety outcomes were compared for the CKD cohort (eGFR <60 mL/min per 1.73 m(2) ) versus those without CKD. Within the CKD cohort, the same analyses were performed comparing sitagliptin- and placebo-assigned participants...
April 22, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28432740/novel-3q27-2-qter-deletion-in-a-patient-with-diamond-blackfan-anemia-and-immunodeficiency-case-report-and-review-of-literature
#9
Ebba Alkhunaizi, Brett Schrewe, Reza Alizadehfar, Catherine Vézina, Grant S Stewart, Nancy Braverman
3q27.2-qter deletion syndromes feature an overlapping set of terminal and interstitial deletions with variable congenital malformations. Diamond-Blackfan anemia (DBA) is etiologically heterogeneous disorder in which one cause is dominant mutations of the RPL35A gene on 3q29. We report a child with a 3q27.2-qter deletion that contains the RPL35A gene. She had clinical and laboratory features consistent with DBA and as well, an unexplained immunodeficiency disorder. Given these unusual findings, we reviewed other patients in the literature with overlapping genomic deletions...
April 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28432698/quantitative-evaluation-of-metal-artifacts-using-different-cbct-devices-high-density-materials-and-field-of-views
#10
Marina Codari, Karla de Faria Vasconcelos, Laura Ferreira Pinheiro Nicolielo, Francisco Haiter Neto, Reinhilde Jacobs
OBJECTIVE: To objectively compare the influence of different cone-beam computed tomography (CBCT) devices, high-density materials and field of views (FOVs) on metal artifact expression. MATERIAL AND METHODS: For this in vitro study, three customized acrylic resin phantoms containing high-density materials cylinders: titanium, copper-aluminum alloy and amalgam were scanned on three CBCT devices using high-resolution protocols, same voxel size (0.2 mm) and different FOVs...
April 22, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28432674/partial-volume-correction-of-brain-pet-studies-using-iterative-deconvolution-in-combination-with-hypr-denoising
#11
Sandeep S V Golla, Mark Lubberink, Bart N M van Berckel, Adriaan A Lammertsma, Ronald Boellaard
BACKGROUND: Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also increases noise, which results in lower signal-to-noise ratios (SNR). The aim of this study was to implement IDM in combination with HighlY constrained back-PRojection (HYPR) denoising to mitigate poor SNR properties of conventional IDM...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28432638/community-gardens-as-environmental-health-interventions-benefits-versus-potential-risks
#12
REVIEW
W K Al-Delaimy, M Webb
PURPOSE OF REVIEW: The purpose of this paper was to summarize current findings on community gardens relevant to three specific areas of interest as follows: (1) health benefits, (2) garden interventions in developing versus developed countries, and (3) the concerns and risks of community gardening. RECENT FINDINGS: Community gardens are a reemerging phenomenon in many low- and high-income urban neighborhoods to address the common risk factors of modern lifestyle...
April 21, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28432629/aquatic-photolysis-of-hydroxylated-polybromodiphenyl-ethers-under-direct-uv-irradiation-a-case-study-of-2-ho-bde-68
#13
Bentuo Xu, Minghong Wu, Chenyuan Pan, Yan Sun, Debao Yuan, Liang Tang, Gang Xu
Hydroxylated polyhalodiphenyl ethers (HO-PXDEs) have attracted considerable scientific interest as examples of emerging aquatic pollutants. However, a comprehensive assessment of disposal methods for this particular pollutant was seldom investigated. This study examined the UV light degradation of HO-PXDEs, using 2'-HO-2, 3', 4, 5'-tetrabromodiphenyl ether (2'-HO-BDE-68) as a case study. The results showed that UV light was superior to visible light and electron beam irradiation for producing a high degradation rate of 2'-HO-BDE-68...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432596/exploiting-the-wnt-signaling-pathway-for-clinical-purposes
#14
REVIEW
Mark L Johnson, Robert R Recker
PURPOSE OF REVIEW: The goal of this paper is to evaluate critically the literature published over the past 3 years regarding the Wnt signaling pathway. The Wnt pathway was found to be involved in bone biology in 2001-2002 with the discovery of a (G171V) mutation in the lipoprotein receptor-related protein 5 (LRP5) that resulted in high bone mass and another mutation that completely inactivated Lrp5 function and resulted in osteoporosis pseudoglioma syndrome (OPPG). The molecular biology has been complex, and very interesting...
April 21, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28432544/expression-of-cphb-and-cphe-type-cyanophycinases-in-cyanophycin-producing-tobacco-and-comparison-of-their-ability-to-degrade-cyanophycin-in-plant-and-plant-extracts
#15
Daniel Ponndorf, Inge Broer, Henrik Nausch
Increasing the arginine (Arg) content in plants used as feed or food is of interest, since the supplementation of food with conditionally essential Arg has been shown to have nutritional benefits. An increase was achieved by the expression of the Arg-rich bacterial storage component, cyanophycin (CGP), in the chloroplast of transgenic plants. CGP is stable in plants and its degradation into β-aspartic acid (Asp)-Arg dipeptides, is solely catalyzed by bacterial cyanophycinases (CGPase). Dipeptides can be absorbed by animals even more efficiently than free amino acids (Matthews and Adibi 1976; Wenzel et al...
April 21, 2017: Transgenic Research
https://www.readbyqxmd.com/read/28432473/vasopressin-and-vasopressin-antagonists-in-heart-failure
#16
Julie K Vishram-Nielsen, Finn Gustafsson
Despite the introduction of multiple new pharmacological agents over the past three decades in the field of heart failure (HF), overall prognosis remains poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy. Elevated levels of arginine vasopressin (AVP), a peptide hormone produced in the hypothalamus, play a role in development of hyponatremia, and AVP and its surrogate, copeptin, are related to changes in osmolality, hemodynamics, neuro-hormones as well as in overall outcome in HF patients...
April 22, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28432418/-because-we-feel-we-have-to-do-something-barriers-in-the-prevention-of-violence-and-key-areas-requiring-action-a%C3%A2-qualitative-interview-study-with-professional-nurses-and-managers-in-the-field-of-elderly-care
#17
Melanie Siegel, Yuliya Mazheika, Regina Mennicken, Stefanie Ritz-Timme, Hildegard Graß, Britta Gahr
BACKGROUND: In recent years, politics and society have shown an increasing interest in the prevention of violence. Despite the scientific studies and prevention programs that have been conducted over the past few years, there is no indication that the prevalence of violence in elderly care is falling. A high number of unreported cases may still be assumed. OBJECTIVE: The present study examined the barriers in transferring research knowledge into practice. Furthermore, it dealt with the requirements of an interventional approach which is practical and which effectively addresses the barriers...
April 21, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28432361/disease-biomarker-identification-from-gene-network-modules-for-metastasized-breast-cancer
#18
Pooja Sharma, Dhruba K Bhattacharyya, Jugal Kalita
Advancement in science has tended to improve treatment of fatal diseases such as cancer. A major concern in the area is the spread of cancerous cells, technically refered to as metastasis into other organs beyond the primary organ. Treatment in such a stage of cancer is extremely difficult and usually palliative only. In this study, we focus on finding gene-gene network modules which are functionally similar in nature in the case of breast cancer. These modules extracted during the disease progression stages are analyzed using p-value and their associated pathways...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432323/refractive-index-tomograms-and-dynamic-membrane-fluctuations-of-red-blood-cells-from-patients-with-diabetes-mellitus
#19
SangYun Lee, HyunJoo Park, Kyoohyun Kim, YongHak Sohn, Seongsoo Jang, YongKeun Park
In this paper, we present the optical characterisations of diabetic red blood cells (RBCs) in a non-invasive manner employing three-dimensional (3-D) quantitative phase imaging. By measuring 3-D refractive index tomograms and 2-D time-series phase images, the morphological (volume, surface area and sphericity), biochemical (haemoglobin concentration and content) and mechanical (membrane fluctuation) parameters were quantitatively retrieved at the individual cell level. With simultaneous measurements of individual cell properties, systematic correlative analyses on retrieved RBC parameters were also performed...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432315/experimental-evidence-of-fano-resonances-in-nanomechanical-resonators
#20
Stefano Stassi, Alessandro Chiadò, Giuseppe Calafiore, Gianluca Palmara, Stefano Cabrini, Carlo Ricciardi
Fano resonance refers to an interference between localized and continuum states that was firstly reported for atomic physics and solid-state quantum devices. In recent years, Fano interference gained more and more attention for its importance in metamaterials, nanoscale photonic devices, plasmonic nanoclusters and surface-enhanced Raman scattering (SERS). Despite such interest in nano-optics, no experimental evidence of Fano interference was reported up to now for purely nanomechanical resonators, even if classical mechanical analogies were referred from a theoretical point of view...
April 21, 2017: Scientific Reports
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