keyword
https://read.qxmd.com/read/38537211/68ga-dota-iba-uptake-in-breast-cancer
#1
JOURNAL ARTICLE
Feifan Xiang, Huipan Liu, Xiaoqi Tan, Yue Chen
A 77-year-old woman with recently diagnosed breast cancer underwent 68Ga-labeled DOTA-ibandronic acid (68Ga-DOTA-IBA) PET/CT scan for the evaluation of bone metastases. The examination revealed increased tracer uptake, indicating that the cervical vertebrae presented osteoblastic metastasis. Interestingly, the breast cancer also showed enhanced activity of 68Ga-DOTA-IBA.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537208/68ga-fapi-pet-ct-in-an-interesting-case-of-metastatic-pulmonary-meningioma
#2
JOURNAL ARTICLE
Priyavrat Purohit, Bhagwant Rai Mittal, Rajender Kumar, Harmandeep Singh, Jaya Shukla, Amanjit Bal, Navneet Singh
Meningiomas are one of the major primary CNS tumors. Most meningiomas are benign, but rarely, these metastasize to distant organs, the lungs being the commonest site of metastasis. 18F-FDG PET/CT has been used to evaluate metastatic pulmonary meningioma. However, 68Ga-FAPI PET/CT has not yet been evaluated. The present case highlights the 68Ga-FAPI uptake in metastatic pulmonary meningioma in a postoperated case of left tentorial meningioma presenting with lung masses. Image-guided biopsy from the lung mass was consistent with metastatic meningioma...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537203/68ga-dotanoc-pet-ct-in-2-siblings-with-von-hippel-lindau-disease
#3
JOURNAL ARTICLE
Priyanka G B, Nishikant Avinash Damle, Ravindranath Reddy K, Nikhil Tandon, Priyanka Naranje, Devasenathipathy Kandasamy, Kishan Subudhi
Von Hippel-Lindau disease is a rare multisystem disorder that shows autosomal dominant inheritance. It is a cancer syndrome that is characterized by the development of a variety of benign and malignant tumors-CNS hemangioblastomas, retinal angiomas, endolymphatic sac tumors, renal cysts and tumors, pancreatic cysts and tumors, adrenal pheochromocytomas, and epididymal cystadenomas. Here we present the 68Ga-labeled DOTANOC scans of 2 siblings who show an interesting spectrum of findings consistent with Von Hippel-Lindau disease...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537179/dispersion-control-over-molecule-cohesion-exploiting-and-dissecting-the-tipping-power-of-aromatic-rings
#4
JOURNAL ARTICLE
Ricardo A Mata, Tlektes Zhanabekova, Daniel A Obenchain, Martin A Suhm
ConspectusWe have learned over the past years how London dispersion forces can be effectively used to influence or even qualitatively tip the structure of aggregates and the conformation of single molecules. This happens despite the fact that single dispersion contacts are much weaker than competing polar forces. It is a classical case of strength by numbers, with the importance of London dispersion forces scaling with the system size. Knowledge about the tipping points, however difficult to attain, is necessary for a rational design of intermolecular forces...
March 27, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38537170/conflicts-of-interest
#5
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: American Journal of Public Health
https://read.qxmd.com/read/38537150/prediction-of-occult-hemorrhage-in-the-lower-body-negative-pressure-model-initial-validation-of-machine-learning-approaches
#6
JOURNAL ARTICLE
Navid Rashedi, Yifei Sun, Vikrant Vaze, Parikshit Shah, Ryan Halter, Jonathan T Elliott, Norman A Paradis
INTRODUCTION: Detection of occult hemorrhage (OH) before progression to clinically apparent changes in vital signs remains an important clinical problem in managing trauma patients. The resource-intensiveness associated with continuous clinical patient monitoring and rescue from frank shock makes accurate early detection and prediction with noninvasive measurement technology a desirable innovation. Despite significant efforts directed toward the development of innovative noninvasive diagnostics, the implementation and performance of the newest bedside technologies remain inadequate...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537073/the-role-of-robotic-assisted-surgery-in-the-management-of-rectal-cancer-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Chenxion Zhang, Hao Tan, Han Xu, Jiaming Ding
BACKGROUND: Rectal cancer poses a significant global health burden. There is a lack of concrete evidence concerning the benefits of robotic-assisted surgery (RAS) for rectal cancer surgery as compared to laparoscopic and open techniques. To address this gap, we conducted a meta-analysis to assess the intraoperative, postoperative, and safety outcomes of robotic surgery in this context. METHODS: MEDLINE, Scopus, and the Cochrane library were searched till May 2023 for randomized and non-randomized studies comparing robotic surgery with either laparoscopic or open approach for rectal cancers...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536950/trends-in-the-potential-of-stilbenes-to-improve-plant-stress-tolerance-insights-of-plant-defense-mechanisms-in-response-to-biotic-and-abiotic-stressors
#8
REVIEW
Qingchao Gao, Renyu Zheng, Jun Lu, Xue Li, Di Wang, Xinyu Cai, Xueyan Ren, Qingjun Kong
Stilbenes belong to the naturally synthesized plant phytoalexins, produced de novo in response to various biotic and abiotic stressors. The importance of stilbenes in plant resistance to stress and disease is of increasing interest. However, the defense mechanisms and potential of stilbenes to improve plant stress tolerance have not been thoroughly reviewed. This work overviewed the pentose phosphate pathway, glycolysis pathway, shikimate pathway, and phenylalanine pathway occurred in the synthesis of stilbenes when plants are subjected to biotic and abiotic stresses...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536886/socio-economic-disparities-and-predictors-of-fertility-among-adolescents-aged-15-to-19-in-zambia-evidence-from-the-zambia-demographic-and-health-survey-2018
#9
JOURNAL ARTICLE
Samson Shumba, Vanessa Moonga, Thomas Osman Miyoba, Stephen Jere, Jessy Mutale Nkonde, Peter Mumba
Globally, 12 million girls aged 15-19 give birth each year, and Africa hosts 19% of youth aged 15-24. In Zambia, 29% of adolescents experience childbirth, with variations by age. Projections suggest a continued rise in these trends by 2030. Zambia came up with Adolescent Health Strategic Plan 2011-2015 among the specific policies being advocated for was Adolescent-Friendly Health Services (ADFHS) in order to mitigate among others adolescent fertility. The study aims to investigate socio-economic disparities and predictors of fertility in Zambian adolescents aged 15 to 19...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536840/association-of-spironolactone-use-with-risk-of-urinary-tract-cancer-in-the-general-population-a-matched-population-based-cohort-study
#10
JOURNAL ARTICLE
Liang-Cheng Chen, Hsuan-Ju Yang, Ben-Hui Yu, Moon-Sing Lee, Hon-Yi Lin, Wen-Yen Chiou, Dai-Wei Liu, Feng-Chun Hsu, Chia-Hui Chew, Shih-Kai Hung
PURPOSE: The correlation between spironolactone usage and cancer risk has sparked interest. The objective of this study is to examine the association between spironolactone use and the incidence of urinary tract cancer in the general population. METHODS: We conducted a matched population-based cohort study. The study population was obtained from the Taiwan National Health Insurance Research Database (TNHIRD) during the period from 2000 to 2016. The multivariate Cox proportional hazard model was performed to examine the impact of spironolactone use on the risk of urinary tract cancer...
2024: PloS One
https://read.qxmd.com/read/38536792/progress-and-challenges-in-achieving-tuberculosis-elimination-in-india-by-2025-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Abhishek Padhi, Ashwini Agarwal, Mayuri Bhise, Anil Chaudhary, Krupal Joshi, C D S Katoch
BACKGROUND: Tuberculosis (TB) continues to pose a significant public health challenge in India, which is home to one of the highest TB burdens worldwide. This systematic review and meta-analysis will aim to synthesize the anticipated progress and potential challenges in achieving TB elimination in India by 2025. METHODS: A comprehensive search will be conducted across multiple databases, including PubMed, Scopus, and Web of Science, to identify relevant studies...
2024: PloS One
https://read.qxmd.com/read/38536765/autobench-v1-0-benchmarking-automation-for-electronic-structure-calculations
#12
JOURNAL ARTICLE
Rodrigo A Cormanich, Gabriel D da Silva
This work reports on new software for automatic conformer energy benchmarking calculations for flexible molecules. The software workflow consists of four parts: conformational search, preoptimization, optimization, and frequency calculations at a higher level and last calculations using several theoretical levels. The software was written to be user-friendly and versatile to be used by nonexperts in computational chemistry. Any theoretical levels available in either Gaussian 16 or ORCA 5 may be applied in the benchmarking study...
March 27, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38536751/elasticity-and-rheology-of-auxetic-granular-metamaterials
#13
JOURNAL ARTICLE
Daan Haver, Daniel Acuña, Shahram Janbaz, Edan Lerner, Gustavo Düring, Corentin Coulais
The flowing, jamming, and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: A granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson's ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection of auxetic grains based on a re-entrant mechanism and show that each grain exhibits a negative Poisson's ratio regardless of the direction of compression...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536735/solvent-induced-dual-nucleophiles-and-the-%C3%AE-effect-in-the-s-n-2-versus-e2-competition
#14
JOURNAL ARTICLE
Xiangyu Wu, F Matthias Bickelhaupt, Jing Xie
We have quantum chemically investigated how microsolvation affects the various E2 and SN 2 pathways, their mutual competition, and the α-effect of the model reaction system HOO- (H2 O) n + CH3 CH2 Cl, at the CCSD(T) level. Interestingly, we identify the dual nature of the α-nucleophile HOO- which, upon solvation, is in equilibrium with HO- . This solvent-induced dual appearance gives rise to a rich network of competing reaction channels. Among both nucleophiles, SN 2 is always favored over E2, and this preference increases upon increasing microsolvation...
March 27, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38536709/peripheral-hypertrophic-subepithelial-corneal-opacification-role-of-tear-secretion-medication-and-systemic-diseases
#15
JOURNAL ARTICLE
Jana C Riedl, Aminat Misirkhanova, Joanna Wasielica-Poslednik, Alexander K Schuster, Irene Schmidtmann, Manfred E Beutel, Norbert Pfeiffer, Adrian Gericke
BACKGROUND: Peripheral hypertrophic subepithelial corneal opacification (PHSCO) is a corneal disease that may severely affect vision. The major goal of this study was to test the hypothesis that tear secretion, medication and systemic diseases are associated with PHSCO. METHODS: This is a retrospective, case-control study conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. We analysed medical records of patients diagnosed with PHSCO...
March 27, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38536704/networks-of-hydrogen-bond-networks-in-water-clusters
#16
JOURNAL ARTICLE
Andrey M Tokmachev
Water clusters play a prominent role in atmospheric and solution chemistry. Numerous arrangements of protons, H-bond configurations or networks, shape the cluster properties. Studies of small water clusters by cryogenic scanning tunneling microscopy and high-resolution rovibrational spectroscopy have established proton rearrangement mechanisms forming pathways between H-bond networks. The mechanisms, concerted tunneling in particular, describe the local processes connecting pairs of configurations. Here, proton rearrangement networks mapping these transformations are defined and explored to provide a global view of the H-bond configurations in clusters...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536676/exploring-the-knowledge-of-an-outstanding-protein-to-protein-interaction-transformer
#17
JOURNAL ARTICLE
Sen Yang, Peng Cheng, Lingli Ju, Yang Liu, Dawei Feng, Shengqi Wang
Protein-to-protein interaction (PPI) prediction aims to predict whether two given proteins interact or not. Compared with traditional experimental methods of high cost and low efficiency, the current deep learning based approach makes it possible to discover massive potential PPIs from large-scale databases. However, deep PPI prediction models perform poorly on unseen species, as their proteins are not in the training set. Targetting on this issue, the paper first proposes PPITrans, a Transformer based PPI prediction model that exploits a language model pre-trained on proteins to conduct binary PPI prediction...
March 27, 2024: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://read.qxmd.com/read/38536619/acceptability-and-feasibility-of-the-plasma-separation-card-for-an-integrated-model-of-care-for-hbv-and-hcv-screening-among-people-attending-hiv-clinics-in-cameroon-and-uganda
#18
JOURNAL ARTICLE
Camila A Picchio, Aina Nicolàs, Ironne Valdèse Ayemfouo Fofou, Viola Kasone, Magellan Guewo-Fokeng, Claude T Tagny, Teddy Nanyonjo, Hellen Nansumba, Yves Nacel Kouongni, Rita Gaëlle Epse Sezawo Kamdjeu, Emmanuel Seremba, Charles Kouanfack, Isaac Ssewanyana, Richard Njouom, Ariadna Rando Segura, Francisco Rodríguez-Frías, Jean Claude Mbanya, Ponsiano Ocama, Jeffrey V Lazarus
BACKGROUND: Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. METHODS: This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88)...
March 27, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38536610/continuous-detection-of-cobalt-ions-and-pyrophosphates-by-nac-cdte-quantum-dots-fluorescence-probes
#19
JOURNAL ARTICLE
Wanqiu Chen, Ting Chen, Min Fang, Weiju Zhu, Cun Li
In this work, a simple and sensitive N-acetyl-L-cysteine (NAC)-covered CdTe quantum dots (NAC-CdTe QDs) fluorescence probe for continuous detection of Co2+ and pyrophosphate ions (PPi, P2 O7 4- ) was synthesized. The fluorescence of the quantum dots was significantly quenched by Co2+ through the coordination of Co2+ and the carboxyl groups on the NAC-CdTe quantum dots. Interestingly, the combination of NAC-CdTe quantum dots with Co2+ yields a new fluorescence probe of Co2+ -modified NAC-CdTe QDs (Co2+ @NAC-CdTe)...
March 27, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38536557/non-contrast-mri-of-micro-vascularity-of-the-feet-and-toes
#20
JOURNAL ARTICLE
Won C Bae, Vadim Malis, Diana Vucevic, Asako Yamamoto, Katsumi Nakamura, John Lane, Mitsue Miyazaki
PURPOSE: This study aimed to develop novel non-contrast MR perfusion techniques for assessing micro-vascularity of the foot in human subjects. METHODS: All experiments were performed on a clinical 3 T scanner using arterial spin labeling (ASL). Seven healthy subjects (30-72 years old, 5 males and 2 females) were enrolled and bilateral feet were imaged with tag-on and tag-off alternating inversion recovery spin labeling for determining micro-vascularity...
March 27, 2024: Japanese Journal of Radiology
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