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Erika Bálint, Ádám Tajti, Anna Tripolszky, György Keglevich
α-Aminophosphine-type ligands are of interest as building blocks of transition metal complexes. This review focuses on the utilization of α-aminophosphines as monodentate and bidentate ligands in platinum, palladium and rhodium complexes. Besides the linear derivatives, the applications of cyclic α-aminophosphines as ligands are also summarized. Various aspects, such as synthesis, structure and applications, as well as the catalytic activity of these complexes are discussed.
March 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Lynn W Bush, Louis E Bartoshesky, Karen L David, Benjamin Wilfond, Janet L Williams, Ingrid A Holm
Disclaimer: This article is designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality patient care. Adherence to the information contained in this article does not necessarily assure a successful medical outcome. This information and any associated recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, each provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Hans Muilerman
No abstract text is available yet for this article.
March 22, 2018: Nature
Mojtaba Abdi-Jalebi, Zahra Andaji-Garmaroudi, Stefania Cacovich, Camille Stavrakas, Bertrand Philippe, Johannes M Richter, Mejd Alsari, Edward P Booker, Eline M Hutter, Andrew J Pearson, Samuele Lilliu, Tom J Savenije, Håkan Rensmo, Giorgio Divitini, Caterina Ducati, Richard H Friend, Samuel D Stranks
Metal halide perovskites are of great interest for various high-performance optoelectronic applications. The ability to tune the perovskite bandgap continuously by modifying the chemical composition opens up applications for perovskites as coloured emitters, in building-integrated photovoltaics, and as components of tandem photovoltaics to increase the power conversion efficiency. Nevertheless, performance is limited by non-radiative losses, with luminescence yields in state-of-the-art perovskite solar cells still far from 100 per cent under standard solar illumination conditions...
March 21, 2018: Nature
Randall Youngman
The study of inorganic glass structure is critically important for basic glass science and especially the commercial development of glasses for a variety of technological uses. One of the best means by which to achieve this understanding is through application of solid-state nuclear magnetic resonance (NMR) spectroscopy, which has a long and interesting history. This technique is element specific, but highly complex, and thus, one of the many inquiries made by non-NMR specialists working in glass science is what type of information and which elements can be studied by this method...
March 22, 2018: Materials
Pei-Tseng Lee, Jonathan Zirin, Oguz Kanca, Wen-Wen Lin, Karen L Schulze, David Li-Kroeger, Rong Tao, Colby Devereaux, Yanhui Hu, Verena Chung, Ying Fang, Yuchun He, Hongling Pan, Ming Ge, Zhongyuan Zuo, Benjamin E Housden, Stephanie E Mohr, Shinya Yamamoto, Robert W Levis, Allan C Spradling, Norbert Perrimon, Hugo J Bellen
We generated a library of ~1,000 Drosophila stocks in which we inserted a construct in the intron of genes allowing expression of GAL4 under control of endogenous promoters while arresting transcription with a polyadenylation signal 3' of the GAL4. This allows numerous applications. First, ~90% of insertions in essential genes cause a severe loss-of-function phenotype, an effective way to mutagenize genes. Interestingly, 12/14 chromosomes engineered through CRISPR do not carry second-site lethal mutations. Second, 26/36(70%) of lethal insertions tested are rescued with a single UAS- cDNA construct...
March 22, 2018: ELife
Xiaobin Mo, Timothy D R Morgan, Hwee Ting Ang, Dennis G Hall
Catalytic activation of hydroxyl functionalities is of great interest for the production of pharmaceuticals and commodity chemicals. Here, 2-alkoxycarbonyl- and 2-phenoxycarbonyl-phenylboronic acid were identified as efficient catalysts for the direct and chemoselective activation of oxime N-OH bonds in the Beckmann rearrangement. This classical organic reaction provides a unique approach to prepare functionalized amide products that may be difficult to access using traditional amide coupling between carboxylic acids and amines...
March 22, 2018: Journal of the American Chemical Society
Kai Wang, Xiaoguang Xu, Liying Lu, Haicheng Wang, Yan Li, Yong Wu, Jun Miao, Jin Z Zhang, Yong Jiang
Ag/Bi2 Fe4 O9 nanoparticles (BFO NPs) have been synthesized using a two step approach involving glycine combustion and visible light irradiation. Their structures were characterized in detail using XRD, TEM, SEM, and STEM techniques. Their electrocatalytic properties were studied through enzymatic glucose detection with an amperometric biosensor. The Ag deposited on selective crystal facets of BFO NPs significantly enhanced their electrocatalytic activity. To gain insight into the origin of the enhanced electrocatalytic activities, we have carried out studies of Ag+ reduction and Mn2+ oxidation reaction at {200} and {001} facets, respectively...
March 22, 2018: ACS Applied Materials & Interfaces
(no author information available yet)
In the context of the White Book of Physical and Rehabilitation Medicine (PRM), this paper deals with Research, the future of PRM. PRM students and specialists are mainly involved in biomedical research, investigating the biological processes, the causes of diseases, their medical diagnosis, the evaluation of their consequences on functioning, disability and health and the effects of health interventions at an individual and a societal level. Most of the current PRM research, often interdisciplinary, originates from applied research which, using existing knowledge, is directed towards specific goals...
April 2018: European Journal of Physical and Rehabilitation Medicine
Ming-Yen Lu, Shang-Chi Wu, Hsiang-Chen Wang, Ming-Pei Lu
As the feature sizes of devices decrease to the nanoscale, electron microscopy and lithography will become increasingly essential techniques for fabrication and inspection. In this study, we probed the memory effects of MoS2 field-effect transistors (FETs) subjected to electron beam (e-beam) irradiation; after fabricating the devices on 300 nm SiO2/Si substrates, we irradiated the MoS2 FETs with various doses of irradiation from a 30 kV e-beam. The threshold voltage shifted to the negative side and the mobility increased-a so-called memory effect-upon increasing the e-beam dose...
March 22, 2018: Physical Chemistry Chemical Physics: PCCP
Jasmin C Athas, Catherine P Nguyen, Shailaa Kummar, Srinivasa R Raghavan
The spontaneous folding of flat gel films into tubes is an interesting example of self-assembly. Typically, a rectangular film folds along its short axis when forming a tube; folding along the long axis has been seen only in rare instances when the film is constrained. Here, we report a case where the same free-swelling gel film folds along either its long or short axis depending on the concentration of a solute. Our gels are sandwiches (bilayers) of two layers: a passive layer of cross-linked N,N'-dimethylyacrylamide (DMAA) and an active layer of cross-linked DMAA that also contains chains of the biopolymer alginate...
March 22, 2018: Soft Matter
Ahmed S Bayoumi, Tatsuya Aonuma, Jian-Peng Teoh, Yao-Liang Tang, Il-Man Kim
Recent advancements in genome-wide analyses and RNA-sequencing technologies led to the discovery of small noncoding RNAs, such as microRNAs (miRs), as well as both linear long noncoding RNAs (lncRNAs) and circular long noncoding RNAs (circRNAs). The importance of miRs and lncRNAs in the treatment, prognosis and diagnosis of cardiovascular diseases (CVDs) has been extensively reported. We also previously reviewed their implications in therapies and as biomarkers for CVDs. More recently, circRNAs have also emerged as important regulators in CVDs...
March 22, 2018: Acta Pharmacologica Sinica
Miles B Markus
A curious aspect of the evolution of the hypnozoite theory of malarial relapse is its transmogrification from theory into 'fact', this being of historical, linguistic, scientific and sociological interest. As far as it goes, the hypnozoite explanation for relapse is almost certainly correct. I contend, however, that many of the genotypically homologous, non-reinfection, relapse-like Plasmodium vivax recurrences that researchers ascribe to hypnozoite activation are probably hypnozoite-independent. Indeed, some malariologists are starting to recognize that homologous P...
March 22, 2018: Parasitology
Hui Wang, Tao Feng, Ning Hai Zhuang, Min Zhi Xu, Ran Ye, Min Sun
This review attempts to visualize the actual impact of starch nanoparticle-based materials in different areas. In recent patent databases, starch nanoparticles showed the importance of this material, as well as relevant topics concerning the applications of starch nanoparticles in different domains. Because starch is environmentally friendly, starch nanoparticles are suggested as one of the promising biomaterials for novel utilization in foods, papermaking, medicines as well as various composites. In this review, the most common techniques for starch nanoparticles preparation were found to be acid and enzymatic procedures, ultrasonic treatment, combination of hydrolysis and Ultrasonic treatment, high pressure homogenization, enzymatic hydrolysis and recrystallization and emulsion-crosslinking...
March 20, 2018: Recent Patents on Food, Nutrition & Agriculture
Kyriaki Hatziagapiou, Eleni Kakouri, George I Lambrou, Kostas Bethanis, Petros A Tarantilis
BACKGROUND: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is growing interest in Crocus Sativus L...
March 20, 2018: Current Neuropharmacology
Judi Mesman, Nobert Basweti, Joseph Misati
The Gusii in rural Kenya represent a particularly interesting community for the study of sensitivity, as they have previously been described as not showing sensitive care. This study focuses on the observation of sensitivity in seven families with a 7-to 23-month-old infant, with extensive naturalistic video observations (ca. 2-4 h per infant) in a multiple caregiver setting, and potential co-existing harsh parenting practices. The average score for received sensitive caregiving was rather low at 5.3, but four out of seven infants were rated as receiving at least adequately sensitive care...
March 22, 2018: Attachment & Human Development
Yunyun Jiang, Jian Zhang, Xiao Zhao, Wen Zhao, Zhijian Yu, Chao Chen, Zhennai Yang
Lactobacillus plantarum (L. plantarum) K25 is a probiotic strain isolated from Tibetan kefir. Previous studies showed that this exopolysaccharide (EPS)-producing strain was antimicrobial active and cold tolerant. These functional traits were evidenced by complete genome sequencing of strain K25 with a circular 3,175,846-bp chromosome and six circular plasmids, encoding 3365 CDSs, 16 rRNA genes and 70 tRNA genes. Genomic analysis of L. plantarum K25 illustrates that this strain contains the previous reported mechanisms of probiotic functionality and cold tolerance, involving plantaricins, lysozyme, bile salt hydrolase, chaperone proteins, osmoprotectant, oxidoreductase, EPSs and terpenes...
March 22, 2018: Bioscience, Biotechnology, and Biochemistry
Jiayuan Zhao, Jordan Nelson, Oluwabunmi Dada, Georgios Pyrgiotakis, Ilias G Kavouras, Philip Demokritou
Users of electronic cigarettes (e-cigs) are exposed to particles and other gaseous pollutants. However, major knowledge gaps on the physico-chemical properties of such exposures and contradictory data in published literature prohibit health risk assessment. Here, the effects of product brand, type, e-liquid flavoring additives, operational voltage, and user puffing patterns on emissions were systematically assessed using a recently developed, versatile, e-cig exposure generation platform and state-of-the-art analytical methods...
March 22, 2018: Inhalation Toxicology
Maxime Tindong, John N Palle, Daniel Nebongo, Leopold Ndemnge Aminde, Yannick Mboue-Djieka, Nicole T Fouda Mbarga, Mesmin Y Dehayem, Siméon-Pierre Choukem
This study aimed to determine the prevalence of diabetic foot ulcer and high risk for ulceration, describe the clinical presentation, and identify factors associated with diabetic foot ulcer in the Southwest regional hospitals of Cameroon. In this cross-sectional study, data were collected using a structured questionnaire administered to consecutive patients with diabetes. Findings from detailed foot examination were recorded. Diabetic foot ulcer was diagnosed according to the International Working Group on Diabetic Foot (IWGDF) definition...
March 1, 2018: International Journal of Lower Extremity Wounds
Paolo Fogagnolo, Maurizio Digiuni, Giovanni Montesano, Chiara Rui, Marco Morales, Luca Rossetti
BACKGROUND: Compass (CenterVue, Padova, Italy) is a fundus automated perimeter which has been introduced in the clinical practice for glaucoma management in 2014. The aim of the article is to review Compass literature, comparing its performances against Humphrey Field Analyzer (Zeiss Humphrey Systems, Dublin, CA, USA). RESULTS: Analyses on both normal and glaucoma subjects agree on the fact that Humphrey Field Analyzer and Compass are interchangeable, as the difference of their global indices is largely inferior than test -retest variability for Humphrey Field Analyzer...
March 1, 2018: European Journal of Ophthalmology
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