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Psp tuberculosis

Janani Ravi, Vivek Anantharaman, L Aravind, Maria Laura Gennaro
The phage shock protein (Psp) stress-response system protects bacteria from envelope stress through a cascade of interactions with other proteins and membrane lipids to stabilize the cell membrane. A key component of this multi-gene system is PspA, an effector protein that is found in diverse bacterial phyla, archaea, cyanobacteria, and chloroplasts. Other members of the Psp system include the cognate partners of PspA that are part of known operons: pspF||pspABC in Proteobacteria, liaIHGFSR in Firmicutes, and clgRpspAMN in Actinobacteria...
May 2018: Antonie Van Leeuwenhoek
Gregory A Grant
Almost all organisms contain the same biosynthetic pathway for the synthesis of l-serine from the glycolytic intermediate, D-3-phosphoglycerate. However, regulation of this pathway varies from organism to organism. Many organisms control the activity of the first enzyme in the pathway, D-3-phosphoglyerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme. The last enzyme in the pathway, phosphoserine phosphatase (PSP) has also been reported to be inhibited by l-serine...
November 15, 2017: Biochemistry
Aaron R Casha, Marco Scarci
The evidence behind the strong correlation between reactivation of tuberculosis (TB) and low body mass index (BMI) was reviewed. This strong association between TB and BMI occurred only with pulmonary TB and not extra-pulmonary TB, indicating that a low-BMI body build may in some way predispose to TB reactivation in the lungs. A possible explanation may be the congenital apical lung bullae that occur in 15% of the population and are likely to enlarge in young low-BMI males since biomechanical modeling of pleural stress has shown a massive 40x increase in apical pleural stress in low antero-posterior (AP) diameter chests associated with a low-BMI build...
March 2017: Journal of Thoracic Disease
Aaron R Casha, Alexander Manché, Liberato Camilleri, Ruben Gatt, Krzysztof Dudek, Michael Pace-Bardon, Marilyn Gauci, Joseph N Grima
OBJECTIVE: A hypothesis is presented suggesting that the pathogenesis of apical lung disease is due to progression of subclinical congenital apical bullae in people with low Body Mass Index (BMI), a combination present in 15% of the population, due to high pleural stress levels present in the antero-posteriorly flattened chests of these individuals. DESIGN: The hypothesis was tested for validity in two apical lung pathologies with widespread epidemiological literature, namely tuberculosis (TB) and primary spontaneous pneumothorax (PSP), assessing whether the hypothesis could identify high-risk populations, explain exceptional cases like apical lower lobe disease and confirm predictions...
July 2016: Medical Hypotheses
Yellapu Gayatridevi, Namballa Usharani, Allena Premkumar, Gorantla Sambasivarao, Vipparthi Surya Kumari, Sarella Joshua
BACKGROUND: Pneumothorax is an important cause of morbidity and mortality, but limited data are available regarding the aetiology, clinical profile, management and outcome of spontaneous pneumothorax from India in recent times. METHODS: This was a retrospective observational study conducted at a Government chest hospital which included patients with the diagnosis of spontaneous pneumothorax seen over a period of one year. Demographic, clinical, radiological and treatment data were collected from hospital records and analysed...
October 2015: Indian Journal of Chest Diseases & Allied Sciences
Richard M Armstrong, Katherine L Adams, Joseph E Zilisch, Daniel J Bretl, Hiromi Sato, David M Anderson, Thomas C Zahrt
UNLABELLED: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a significant cause of morbidity and mortality worldwide, despite the availability of a live attenuated vaccine and anti-TB antibiotics. The vast majority of individuals infected with M. tuberculosis develop an asymptomatic latent infection in which the bacterium survives within host-generated granulomatous lesions in a physiologically altered metabolic state of nonreplicating persistence. The granuloma represents an adverse environment, as M...
June 1, 2016: Journal of Bacteriology
Aparup Dhua, Arunabha Datta Chaudhuri, Susmita Kundu, Sumit Roy Tapadar, Sourin Bhuniya, Bijan Ghosh, Subhasis Mukherjee, Soumya Bhattacharya
CONTEXT: Pneumothorax continues to be a major cause of morbidity and mortality among respiratory patients, but there is a paucity of data regarding etiology, clinical profile, management, and outcome of spontaneous pneumothorax (SP), from this part of the world. AIMS: To assess the patients of spontaneous pneumothorax in adults with special reference to the etiology, clinical presentation, management, and outcome of SP. SETTINGS AND DESIGN: Prospective, observational study conducted in a tertiary care institution over a period of one year...
March 2015: Lung India: Official Organ of Indian Chest Society
Gaya Prasad Yadav, Sonal Shree, Ruchi Maurya, Niyati Rai, Diwakar Kumar Singh, Kishore Kumar Srivastava, Ravishankar Ramachandran
M. tuberculosis harbors an essential phosphoserine phosphatase (MtSerB2, Rv3042c) that contains two small- molecule binding ACT-domains (Pfam 01842) at the N-terminus followed by the phosphoserine phosphatase (PSP) domain. We found that exogenously added MtSerB2 elicits microtubule rearrangements in THP-1 cells. Mutational analysis demonstrates that phosphatase activity is co-related to the elicited rearrangements, while addition of the ACT-domains alone elicits no rearrangements. The enzyme is dimeric, exhibits divalent metal- ion dependency, and is more specific for l- phosphoserine unlike other classical PSPases...
2014: PloS One
Garima Arora, Prabhakar Tiwari, Rahul Shubhra Mandal, Arpit Gupta, Deepak Sharma, Sudipto Saha, Ramandeep Singh
The emergence of drug-resistant strains of Mycobacterium tuberculosis makes identification and validation of newer drug targets a global priority. Phosphoserine phosphatase (PSP), a key essential metabolic enzyme involved in conversion of O-phospho-l-serine to l-serine, was characterized in this study. The M. tuberculosis genome harbors all enzymes involved in l-serine biosynthesis including two PSP homologs: Rv0505c (SerB1) and Rv3042c (SerB2). In the present study, we have biochemically characterized SerB2 enzyme and developed malachite green-based high throughput assay system to identify SerB2 inhibitors...
September 5, 2014: Journal of Biological Chemistry
Yongli Song, Xiaoning He, Song Hua, Jie Lan, Yonggang Liu, Pang Cheng, Hailin Zhang, Jixia Li, Xiaoying He, Jun Liu, Yong Zhang
The purpose of this study was to prepare intracellular pathogen resistance 1 (Ipr1) transgenic donor cells for somatic cell nuclear transfer (SCNT). Based on our current understanding of Ipr1, a macrophage special expression vector pSP-EGFP-Ipr1was constructed. Bovine fetal fibroblasts were transfected with pSP-EGFP-Ipr1. The green fluorescent protein (GFP)-expressing cells were selected and transferred into enucleated bovine oocytes. Then, the rates of oocyte cleavage and blastocyst formation of transgenic cells and non-transgenic cells were observed, respectively...
August 2013: Zygote: the Biology of Gametes and Early Embryos
Aude Ragas, Lucie Roussel, Germain Puzo, Michel Rivière
Tuberculosis is still a major health problem, and understanding the mechanism by which Mycobacterium tuberculosis (Mtb) invades and colonizes its host target cells remains an important issue for the control of infection. The innate immune system C-type lectins (C-TLs), including the human pulmonary surfactant protein A (PSP-A), have been recently identified as determinant players in the early recognition of the invading pathogen and in mounting the host defense response. Although the antigenic lipoglycan mannosylated lipoarabinomannan is currently considered to be the major C-TL target on the mycobacterial surface, the recognition by some C-TLs of the only mycobacterial species composing the "Mtb complex" indicates that mannosylated lipoarabinomannan cannot account alone for this specificity...
February 23, 2007: Journal of Biological Chemistry
Dheeraj Gupta, Sanjay Mishra, Shoaib Faruqi, Ashutosh N Aggarwal
BACKGROUND: Limited information is available on epidemiology of spontaneous pneumothorax (SP) from India. The present study was aimed at studying aetiology and clinical profile of patients with SP. METHODS: All patients admitted at a tertiary care hospital with the diagnosis of SP between January 2001 and March 2002 were prospectively studied. Detailed demographic and clinical data were recorded. Patients were divided into two groups-primary spontaneous pneumothorax (PSP), if no underlying aetiology for pneumothorax was found, and secondary spontaneous pneumothorax (SSP), when an underlying respiratory disorder could be identified...
October 2006: Indian Journal of Chest Diseases & Allied Sciences
J Ward, V Siskind, A Konstantinos
SETTING: Queensland tuberculosis (TB) control centre QTCC). OBJECTIVE: To investigate patient and health care system delays in the diagnosis of active TB in Queensland. DESIGN: Analysis of data extracted from the QTCC database and review of charts. Symptomatic patients with bacteriologically or histologically proven TB were considered as a total group and a pulmonary smear-positive (PSP) group. RESULTS: The median patient delays were 29 days (total group) and 30 days (PSP group)...
November 2001: International Journal of Tuberculosis and Lung Disease
B Andrés, J Luján, R Robles, J Aguilar, B Flores, P Parrilla
Our aim is to assess the results of surgical treatment for spontaneous pneumothorax (SP) using video-assisted thoracoscopic surgery (VATS) and to determine whether this technique is equally effective for primary SP (PSP) and secondary SP (SSP). A prospective study was performed on 54 patients with persistent and recurrent SP (42 PSPs and 12 SSPs). Mean operating time, time before drainage removal, and hospital stay were significantly longer with SSP (67.1 vs. 48.1 minutes; 5.4 vs. 3.6 days; and 7.7 vs. 5.3 days; p < 0...
April 1998: Surgical Laparoscopy & Endoscopy
A I Ershov, V A Tikhonov, S I Sharunov, M P Gracheva, Iu A Evstafév, S P Zavrazhnov, Iu G Grigorév
A total of 2840 patients with pulmonary tuberculosis and bronchial asthma were studied. Antigens are shown to induce a systemic vascular response with elevated systolic pressure in the pulmonary artery, peripheral venous spasms. There is activation of the sympathoadrenal system and desensitization of beta-adrenoreceptors with lower levels of cyclic adenosine monophosphate (CAMP). There is a direct correlation between the CAMP levels and the cardiac output, between those and the pulmonary systolic pressure (PSP)...
1994: Problemy Tuberkuleza
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