keyword
https://read.qxmd.com/read/37977835/pulmonary-sclerosing-pneumocytoma-approaching-a-solitary-pulmonary-nodule-and-the-limitations-of-risk-prediction-models
#1
JOURNAL ARTICLE
Kundan Reddy Saripalli, Mark Qi Wei Wang, Chun Yuen Chow, Si Yuan Chew
Our case is an asymptomatic, non-smoking, East Asian woman in her 40s presenting with a solitary pulmonary nodule (SPN). On imaging, the 1.7 cm solid SPN located in the left upper lobe, was rounded in morphology and moderately fluorodeoxyglucose avid. The clinical pretest probability of malignancy assessed by risk prediction models such as Brock (19.1%), Mayo Clinic (56.2%) and Herder (51.4%) was discordant. She underwent a percutaneous CT-guided needle biopsy, establishing a diagnosis of pulmonary sclerosing pneumocytoma (PSP)...
November 17, 2023: BMJ Case Reports
https://read.qxmd.com/read/36870931/-guidelines-for-management-of-patients-with-primary-spontaneous-pneumothorax
#2
S Jouneau, J-D Ricard, A Seguin-Givelet, N Bigé, D Contou, T Desmettre, D Hugenschmitt, S Kepka, K Le Gloan, B Maitre, G Mangiapan, S Marchand-Adam, A Mariolo, T Marx, J Messika, E Noël-Savina, M Oberlin, L Palmier, M Perruez, C Pichereau, N Roche, M Garnier, M Martinez
No abstract text is available yet for this article.
March 2023: Revue des Maladies Respiratoires
https://read.qxmd.com/read/36867613/pre-slaughter-slaughter-and-post-slaughter-practices-of-slaughterhouse-workers-in-southeast-nigeria-animal-welfare-meat-quality-food-safety-and-public-health-implications
#3
JOURNAL ARTICLE
Emmanuel O Njoga, Stanley U Ilo, Obichukwu C Nwobi, Onyinye S Onwumere-Idolor, Festus E Ajibo, Chinwe E Okoli, Ishmael F Jaja, James W Oguttu
BACKGROUND: Pre-slaughter stress or the welfare condition of food-producing animals (FPAs) and the slaughter practices of slaughterhouse workers (SHWs) are critically important for the safety and quality of meats processed in slaughterhouses (SHs). Consequently, this study determined the pre-slaughter, slaughter, and post-slaughter (PSP) practices of SHWsin four SHs in Southeast, Nigeria; and discussed the impacts on meat quality and safety. METHODS: The PSP practices were determined by observation method...
2023: PloS One
https://read.qxmd.com/read/34304085/bilateral-primary-spontaneous-pneumothorax-with-multiple-bleb-performed-by-vats-and-wedge-resection-a-rare-case-in-indonesian-adult-and-review-article
#4
JOURNAL ARTICLE
Nisya Hapsari, Resti Yudhawati
BACKGROUND: Bilateral primary spontaneous pneumothorax (PSP) is a rare case of lung disease. CASE PRESENTATION: A 20-year-old man with a complaint of shortness of breath is suspected of having PSP and tuberculosis. The patient underwent water seal drainage installation in both lung cavities, but showed no improvement. Multiple blebs were found after a few days. A wedge resection with VATS became an option. The patient had improved lung function after the procedure...
August 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/32782143/biochemical-characterization-of-phosphoserine-phosphatase-serb2-from-mycobacterium-marinum
#5
JOURNAL ARTICLE
Elise Pierson, Johan Wouters
SerB2 is an essential phosphoserine phosphatase (PSP) that has been shown to be involved in Mycobacterium tuberculosis (Mtb) immune evasion mechanisms, and a drug target for the development of new antitubercular agents. A highly similar (91.0%) orthologous enzyme exists in the surrogate organism Mycobacterium marinum (Mma) and could have acquired similar properties. By homology modeling, we show that the two PSPs are expected to exhibit almost identical architectures. MmaSerB2 folds into a homodimer formed by two intertwined subunits including two ACT regulatory domains followed by a catalytic core typical of HAD (haloacid dehalogenase) phosphatases...
October 1, 2020: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/29488183/variations-on-a-theme-evolution-of-the-phage-shock-protein-system-in-actinobacteria
#6
JOURNAL ARTICLE
Janani Ravi, Vivek Anantharaman, L Aravind, Maria Laura Gennaro
The phage shock protein (Psp) stress-response system protects bacteria from envelope stress through a cascade of interactions with other proteins and membrane lipids to stabilize the cell membrane. A key component of this multi-gene system is PspA, an effector protein that is found in diverse bacterial phyla, archaea, cyanobacteria, and chloroplasts. Other members of the Psp system include the cognate partners of PspA that are part of known operons: pspF||pspABC in Proteobacteria, liaIHGFSR in Firmicutes, and clgRpspAMN in Actinobacteria...
May 2018: Antonie Van Leeuwenhoek
https://read.qxmd.com/read/29140686/regulatory-mechanism-of-mycobacterium-tuberculosis-phosphoserine-phosphatase-serb2
#7
JOURNAL ARTICLE
Gregory A Grant
Almost all organisms contain the same biosynthetic pathway for the synthesis of l-serine from the glycolytic intermediate, d-3-phosphoglycerate. However, regulation of this pathway varies from organism to organism. Many organisms control the activity of the first enzyme in the pathway, d-3-phosphoglycerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme. The last enzyme in the pathway, phosphoserine phosphatase (PSP), has also been reported to be inhibited by l-serine...
December 12, 2017: Biochemistry
https://read.qxmd.com/read/28449528/the-link-between-tuberculosis-and-body-mass-index
#8
EDITORIAL
Aaron R Casha, Marco Scarci
The evidence behind the strong correlation between reactivation of tuberculosis (TB) and low body mass index (BMI) was reviewed. This strong association between TB and BMI occurred only with pulmonary TB and not extra-pulmonary TB, indicating that a low-BMI body build may in some way predispose to TB reactivation in the lungs. A possible explanation may be the congenital apical lung bullae that occur in 15% of the population and are likely to enlarge in young low-BMI males since biomechanical modeling of pleural stress has shown a massive 40x increase in apical pleural stress in low antero-posterior (AP) diameter chests associated with a low-BMI build...
March 2017: Journal of Thoracic Disease
https://read.qxmd.com/read/27241265/a-biomechanical-hypothesis-for-the-pathophysiology-of-apical-lung-disease
#9
JOURNAL ARTICLE
Aaron R Casha, Alexander Manché, Liberato Camilleri, Ruben Gatt, Krzysztof Dudek, Michael Pace-Bardon, Marilyn Gauci, Joseph N Grima
OBJECTIVE: A hypothesis is presented suggesting that the pathogenesis of apical lung disease is due to progression of subclinical congenital apical bullae in people with low Body Mass Index (BMI), a combination present in 15% of the population, due to high pleural stress levels present in the antero-posteriorly flattened chests of these individuals. DESIGN: The hypothesis was tested for validity in two apical lung pathologies with widespread epidemiological literature, namely tuberculosis (TB) and primary spontaneous pneumothorax (PSP), assessing whether the hypothesis could identify high-risk populations, explain exceptional cases like apical lower lobe disease and confirm predictions...
July 2016: Medical Hypotheses
https://read.qxmd.com/read/27164729/clinical-profile-of-spontaneous-pneumothorax-in-adults-a-retrospective-study
#10
JOURNAL ARTICLE
Yellapu Gayatridevi, Namballa Usharani, Allena Premkumar, Gorantla Sambasivarao, Vipparthi Surya Kumari, Sarella Joshua
BACKGROUND: Pneumothorax is an important cause of morbidity and mortality, but limited data are available regarding the aetiology, clinical profile, management and outcome of spontaneous pneumothorax from India in recent times. METHODS: This was a retrospective observational study conducted at a Government chest hospital which included patients with the diagnosis of spontaneous pneumothorax seen over a period of one year. Demographic, clinical, radiological and treatment data were collected from hospital records and analysed...
October 2015: Indian Journal of Chest Diseases & Allied Sciences
https://read.qxmd.com/read/27002134/rv2744c-is-a-pspa-ortholog-that-regulates-lipid-droplet-homeostasis-and-nonreplicating-persistence-in-mycobacterium-tuberculosis
#11
JOURNAL ARTICLE
Richard M Armstrong, Katherine L Adams, Joseph E Zilisch, Daniel J Bretl, Hiromi Sato, David M Anderson, Thomas C Zahrt
UNLABELLED: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a significant cause of morbidity and mortality worldwide, despite the availability of a live attenuated vaccine and anti-TB antibiotics. The vast majority of individuals infected with M. tuberculosis develop an asymptomatic latent infection in which the bacterium survives within host-generated granulomatous lesions in a physiologically altered metabolic state of nonreplicating persistence. The granuloma represents an adverse environment, as M...
June 1, 2016: Journal of Bacteriology
https://read.qxmd.com/read/25814797/assessment-of-spontaneous-pneumothorax-in-adults-in-a-tertiary-care-hospital
#12
JOURNAL ARTICLE
Aparup Dhua, Arunabha Datta Chaudhuri, Susmita Kundu, Sumit Roy Tapadar, Sourin Bhuniya, Bijan Ghosh, Subhasis Mukherjee, Soumya Bhattacharya
CONTEXT: Pneumothorax continues to be a major cause of morbidity and mortality among respiratory patients, but there is a paucity of data regarding etiology, clinical profile, management, and outcome of spontaneous pneumothorax (SP), from this part of the world. AIMS: To assess the patients of spontaneous pneumothorax in adults with special reference to the etiology, clinical presentation, management, and outcome of SP. SETTINGS AND DESIGN: Prospective, observational study conducted in a tertiary care institution over a period of one year...
March 2015: Lung India: Official Organ of Indian Chest Society
https://read.qxmd.com/read/25521849/characterization-of-m-tuberculosis-serb2-an-essential-had-family-phosphatase-reveals-novel-properties
#13
JOURNAL ARTICLE
Gaya Prasad Yadav, Sonal Shree, Ruchi Maurya, Niyati Rai, Diwakar Kumar Singh, Kishore Kumar Srivastava, Ravishankar Ramachandran
M. tuberculosis harbors an essential phosphoserine phosphatase (MtSerB2, Rv3042c) that contains two small- molecule binding ACT-domains (Pfam 01842) at the N-terminus followed by the phosphoserine phosphatase (PSP) domain. We found that exogenously added MtSerB2 elicits microtubule rearrangements in THP-1 cells. Mutational analysis demonstrates that phosphatase activity is co-related to the elicited rearrangements, while addition of the ACT-domains alone elicits no rearrangements. The enzyme is dimeric, exhibits divalent metal- ion dependency, and is more specific for l- phosphoserine unlike other classical PSPases...
2014: PloS One
https://read.qxmd.com/read/25037224/high-throughput-screen-identifies-small-molecule-inhibitors-specific-for-mycobacterium-tuberculosis-phosphoserine-phosphatase
#14
JOURNAL ARTICLE
Garima Arora, Prabhakar Tiwari, Rahul Shubhra Mandal, Arpit Gupta, Deepak Sharma, Sudipto Saha, Ramandeep Singh
The emergence of drug-resistant strains of Mycobacterium tuberculosis makes identification and validation of newer drug targets a global priority. Phosphoserine phosphatase (PSP), a key essential metabolic enzyme involved in conversion of O-phospho-l-serine to l-serine, was characterized in this study. The M. tuberculosis genome harbors all enzymes involved in l-serine biosynthesis including two PSP homologs: Rv0505c (SerB1) and Rv3042c (SerB2). In the present study, we have biochemically characterized SerB2 enzyme and developed malachite green-based high throughput assay system to identify SerB2 inhibitors...
September 5, 2014: Journal of Biological Chemistry
https://read.qxmd.com/read/21867594/construction-of-ipr1-expression-vector-and-development-of-cloned-embryos-in-vitro
#15
JOURNAL ARTICLE
Yongli Song, Xiaoning He, Song Hua, Jie Lan, Yonggang Liu, Pang Cheng, Hailin Zhang, Jixia Li, Xiaoying He, Jun Liu, Yong Zhang
The purpose of this study was to prepare intracellular pathogen resistance 1 (Ipr1) transgenic donor cells for somatic cell nuclear transfer (SCNT). Based on our current understanding of Ipr1, a macrophage special expression vector pSP-EGFP-Ipr1was constructed. Bovine fetal fibroblasts were transfected with pSP-EGFP-Ipr1. The green fluorescent protein (GFP)-expressing cells were selected and transferred into enucleated bovine oocytes. Then, the rates of oocyte cleavage and blastocyst formation of transgenic cells and non-transgenic cells were observed, respectively...
August 2013: Zygote: the Biology of Gametes and Early Embryos
https://read.qxmd.com/read/17158455/the-mycobacterium-tuberculosis-cell-surface-glycoprotein-apa-as-a-potential-adhesin-to-colonize-target-cells-via-the-innate-immune-system-pulmonary-c-type-lectin-surfactant-protein-a
#16
JOURNAL ARTICLE
Aude Ragas, Lucie Roussel, Germain Puzo, Michel Rivière
Tuberculosis is still a major health problem, and understanding the mechanism by which Mycobacterium tuberculosis (Mtb) invades and colonizes its host target cells remains an important issue for the control of infection. The innate immune system C-type lectins (C-TLs), including the human pulmonary surfactant protein A (PSP-A), have been recently identified as determinant players in the early recognition of the invading pathogen and in mounting the host defense response. Although the antigenic lipoglycan mannosylated lipoarabinomannan is currently considered to be the major C-TL target on the mycobacterial surface, the recognition by some C-TLs of the only mycobacterial species composing the "Mtb complex" indicates that mannosylated lipoarabinomannan cannot account alone for this specificity...
February 23, 2007: Journal of Biological Chemistry
https://read.qxmd.com/read/16970292/aetiology-and-clinical-profile-of-spontaneous-pneumothorax-in-adults
#17
JOURNAL ARTICLE
Dheeraj Gupta, Sanjay Mishra, Shoaib Faruqi, Ashutosh N Aggarwal
BACKGROUND: Limited information is available on epidemiology of spontaneous pneumothorax (SP) from India. The present study was aimed at studying aetiology and clinical profile of patients with SP. METHODS: All patients admitted at a tertiary care hospital with the diagnosis of SP between January 2001 and March 2002 were prospectively studied. Detailed demographic and clinical data were recorded. Patients were divided into two groups-primary spontaneous pneumothorax (PSP), if no underlying aetiology for pneumothorax was found, and secondary spontaneous pneumothorax (SSP), when an underlying respiratory disorder could be identified...
October 2006: Indian Journal of Chest Diseases & Allied Sciences
https://read.qxmd.com/read/11716338/patient-and-health-care-system-delays-in-queensland-tuberculosis-patients-1985-1998
#18
JOURNAL ARTICLE
J Ward, V Siskind, A Konstantinos
SETTING: Queensland tuberculosis (TB) control centre QTCC). OBJECTIVE: To investigate patient and health care system delays in the diagnosis of active TB in Queensland. DESIGN: Analysis of data extracted from the QTCC database and review of charts. Symptomatic patients with bacteriologically or histologically proven TB were considered as a total group and a pulmonary smear-positive (PSP) group. RESULTS: The median patient delays were 29 days (total group) and 30 days (PSP group)...
November 2001: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/9566562/treatment-of-primary-and-secondary-spontaneous-pneumothorax-using-videothoracoscopy
#19
JOURNAL ARTICLE
B Andrés, J Luján, R Robles, J Aguilar, B Flores, P Parrilla
Our aim is to assess the results of surgical treatment for spontaneous pneumothorax (SP) using video-assisted thoracoscopic surgery (VATS) and to determine whether this technique is equally effective for primary SP (PSP) and secondary SP (SSP). A prospective study was performed on 54 patients with persistent and recurrent SP (42 PSPs and 12 SSPs). Mean operating time, time before drainage removal, and hospital stay were significantly longer with SSP (67.1 vs. 48.1 minutes; 5.4 vs. 3.6 days; and 7.7 vs. 5.3 days; p < 0...
April 1998: Surgical Laparoscopy & Endoscopy
https://read.qxmd.com/read/7984611/-development-of-chronic-cor-pulmonale-in-restrictive-and-obstructive-pulmonary-dysfunctions
#20
JOURNAL ARTICLE
A I Ershov, V A Tikhonov, S I Sharunov, M P Gracheva, Iu A Evstafév, S P Zavrazhnov, Iu G Grigorév
A total of 2840 patients with pulmonary tuberculosis and bronchial asthma were studied. Antigens are shown to induce a systemic vascular response with elevated systolic pressure in the pulmonary artery, peripheral venous spasms. There is activation of the sympathoadrenal system and desensitization of beta-adrenoreceptors with lower levels of cyclic adenosine monophosphate (CAMP). There is a direct correlation between the CAMP levels and the cardiac output, between those and the pulmonary systolic pressure (PSP)...
1994: Problemy Tuberkuleza
keyword
keyword
23873
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.