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Clgr tuberculosis

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https://www.readbyqxmd.com/read/27630619/transcriptional-and-physiological-changes-during-mycobacterium-tuberculosis-reactivation-from-non-replicating-persistence
#1
Peicheng Du, Charles D Sohaskey, Lanbo Shi
Mycobacterium tuberculosis can persist for years in the hostile environment of the host in a non-replicating or slowly replicating state. While active disease predominantly results from reactivation of a latent infection, the molecular mechanisms of M. tuberculosis reactivation are still poorly understood. We characterized the physiology and global transcriptomic profiles of M. tuberculosis during reactivation from hypoxia-induced non-replicating persistence. We found that M. tuberculosis reactivation upon reaeration was associated with a lag phase, in which the recovery of cellular physiological and metabolic functions preceded the resumption of cell replication...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/25422323/the-mycobacterium-tuberculosis-clp-gene-regulator-is-required-for-in-vitro-reactivation-from-hypoxia-induced-dormancy
#2
Amanda McGillivray, Nadia A Golden, Deepak Kaushal
Mycobacterium tuberculosis (Mtb) is the leading cause of death from an infectious disease worldwide and is the causative agent of tuberculosis (Chao, M. C., and Rubin, E. J. (2010) Annu. Rev. Microbiol. 64, 293-311). Throughout infection, Mtb encounters a variety of host pressures. Thus, responding to these host stresses via the induction of multiple regulatory networks is needed for survival within the host. The Clp protease gene regulator, Rv2745c (clgR), is induced in response to environmental stress conditions, implicating its potential role in Mtb pathogenesis...
January 23, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24705585/the-mycobacterium-tuberculosis-rv2745c-plays-an-important-role-in-responding-to-redox-stress
#3
Amanda McGillivray, Nadia Abrahams Golden, Uma Shankar Gautam, Smriti Mehra, Deepak Kaushal
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease worldwide. Over the course of its life cycle in vivo, Mtb is exposed to a plethora of environmental stress conditions. Temporal regulation of genes involved in sensing and responding to such conditions is therefore crucial for Mtb to establish an infection. The Rv2745c (clgR) gene encodes a Clp protease gene regulator that is induced in response to a variety of stress conditions and potentially plays a role in Mtb pathogenesis...
2014: PloS One
https://www.readbyqxmd.com/read/23560081/mycobacterium-tuberculosis-clpp-proteases-are-co-transcribed-but-exhibit-different-substrate-specificities
#4
Yoann Personne, Amanda C Brown, Dorothée L Schuessler, Tanya Parish
Caseinolytic (Clp) proteases are widespread energy-dependent proteases; the functional ATP-dependent protease is comprised of multimers of proteolytic and regulatory subunits. Mycobacterium tuberculosis has two ClpP proteolytic subunits (ClpP1 and ClpP2), with both being essential for growth in vitro. ClpP1 and clpP2 are arranged in an apparent operon; we demonstrated that the two genes are co-expressed under normal growth conditions. We identified a single promoter region for the clpP1P2 operon; no promoter was detected upstream of clpP2 demonstrating that independent expression of clpP1 and clpP2 was highly unlikely...
2013: PloS One
https://www.readbyqxmd.com/read/20688819/clgr-regulation-of-chaperone-and-protease-systems-is-essential-for-mycobacterium-tuberculosis-parasitism-of-the-macrophage
#5
Megan Estorninho, Hilde Smith, Jelle Thole, Jose Harders-Westerveen, Andrzej Kierzek, Rachel E Butler, Olivier Neyrolles, Graham R Stewart
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence. Bacteria have evolved accurate regulatory systems to control the expression and function of chaperones and potentially destructive proteases. Here, we have used a combination of transcriptomics, proteomics and targeted mutagenesis to reveal that the clp gene regulator (ClgR) of Mycobacterium tuberculosis activates the transcription of at least ten genes, including four that encode protease systems (ClpP1/C, ClpP2/C, PtrB and HtrA-like protease Rv1043c) and three that encode chaperones (Acr2, ClpB and the chaperonin Rv3269)...
November 2010: Microbiology
https://www.readbyqxmd.com/read/20661284/characterization-of-a-clp-protease-gene-regulator-and-the-reaeration-response-in-mycobacterium-tuberculosis
#6
Ashley M Sherrid, Tige R Rustad, Gerard A Cangelosi, David R Sherman
Mycobacterium tuberculosis (MTB) enters a non-replicating state when exposed to low oxygen tension, a condition the bacillus encounters in granulomas during infection. Determining how mycobacteria enter and maintain this state is a major focus of research. However, from a public health standpoint the importance of latent TB is its ability to reactivate. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the adaptive response of MTB following a return to favorable growth conditions...
2010: PloS One
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