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https://www.readbyqxmd.com/read/29684567/human-herpesvirus-6b-hhv-6b-reactivation-is-a-risk-factor-for-grade-2-4-acute-graft-versus-host-disease-agvhd-after-hematopoietic-stem-cell-transplantation-hct-a-systematic-review-and-meta-analysis
#1
REVIEW
Tuan L Phan, Kristen Carlin, Per Ljungman, Ioannis Politikos, Vicki Boussiotis, Michael Boeckh, Michele L Shaffer, Danielle M Zerr
BACKGROUND/OBJECTIVE: Graft-versus-host disease (GVHD) is an important cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Many studies have suggested that HHV-6B plays a role in acute GVHD (aGVHD) following HCT. Our objective was to systematically summarize and analyze evidence regarding HHV-6B reactivation and development of aGVHD. METHODS: PubMed and EMBASE databases were searched using terms for HHV-6, HCT, and aGVHD, yielding 865 unique results...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684534/towards-a-maraviroc-long-acting-injectable-nanoformulation
#2
Lee M Tatham, Alison C Savage, Andrew Dwyer, Marco Siccardi, Trevor Scott, Manoli Vourvahis, Andrew Clark, Steven P Rannard, Andrew Owen
Suboptimal adherence to antiretroviral (ARV) therapy can lead to insufficient drug exposure leading to viral rebound and increased likelihood of resistance. This has driven the development of long-acting injectable (LAI) formulations which may mitigate some of these problems. Maraviroc (MVC) is an orally dosed CCR5 antagonist approved for use in patients infected with CCR5-trophic HIV-1. MVC prevents viral entry into host cells, is readily distributed to biologically relevant tissues and has an alternative resistance profile compared to more commonly used therapies...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684327/do-health-promotion-messages-integrate-unintended-pregnancy-and-sti-prevention-a-content-analysis-of-online-information-for-adolescents-and-young-adults
#3
Riley J Steiner, Catherine N Rasberry, Jessica M Sales, Laura M Gaydos, Karen Pazol, Michael Kramer, Andrea Swartzendruber
OBJECTIVE: Recently there have been calls to strengthen integration of unintended pregnancy and sexually transmitted infection (STI) prevention messages, spurred by increasing use of long-acting reversible contraception. To assess the extent to which public health/clinical messages about unintended pregnancy prevention also address STI prevention, we conducted a content analysis of web-based health promotion information for young people. STUDY DESIGN: Websites identified through a systematic Google search were eligible for inclusion if they were operated by a United States-based organization with a mission related to public health/clinical services and the URL included: 1) original content; 2) about sexual and reproductive health; 3) explicitly for adolescents and/or young adults...
April 20, 2018: Contraception
https://www.readbyqxmd.com/read/29683898/angiogenic-factor-profiles-in-pregnant-women-with-a-history-of-early-onset-severe-preeclampsia-receiving-low-molecular-weight-heparin-prophylaxis
#4
Brendan P McDonnell, Carmen Regan
No abstract text is available yet for this article.
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683856/seroconversion-on-prep-a-case-report-with-segmental-hair-analysis-for-timed-adherence-determination
#5
Joshua T Thaden, Monica Gandhi, Hideaki Okochi, Christopher B Hurt, Mehri S McKellar
OBJECTIVE: We describe the third case report of seroconversion with multidrug resistant (MDR)-HIV despite pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir (TFV) disoproxil (TDF). DESIGN: Case report. METHODS: PrEP adherence was assessed via self-report, pharmacy records, and measuring TFV/FTC levels with liquid-chromatography/tandem-mass-spectrometry in plasma and hair. Segmental hair analysis was performed to assess PrEP adherence over prior months...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683840/enhancing-hiv-pre-exposure-prophylaxis-practices-via-an-educational-intervention
#6
Rebecca Newman, Tasleem Katchi, Michael Karass, Melissa Gennarelli, Jason Goutis, Alina Kifayat, Shantanu Solanki, Srikanth Yandrapalli, Leanne Forman, Christopher Nabors
BACKGROUND: Pre-exposure prophylaxis (PrEP) for HIV involves using antiretroviral drugs to prevent individuals at high risk from acquiring HIV infection. Most practicing primary care providers believe PrEP to be safe and effective, but less than half have prescribed or referred for PrEP. Attitudes and prescribing patterns among house officers have not been well described previously. STUDY QUESTION: Can an educational intervention enhance HIV PrEP practices among internal medicine house officers? STUDY DESIGN: This study relied on a pretest/posttest design...
April 20, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29683399/seroprevalence-of-dengue-virus-west-nile-virus-chikungunya-virus-and-zika-virus-in-international-travelers-attending-a-travel-and-migration-center-in-2015-2017-southern-italy
#7
Daniela Loconsole, Angela Metallo, Anna Lisa De Robertis, Anna Morea, Michele Quarto, Maria Chironna
International travelers to areas endemic for vector-borne diseases (VBDs) may be at risk of contracting and spreading these diseases. The aim of this study was to evaluate the prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies that are specific for Dengue Virus (DV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), or Zika Virus (ZV) in a cohort of international travelers. The study enrolled travelers who attended the Travel Medicine and Migration outpatient service of Local Health Unit of Bari, Italy, in March 2015-June 2017 for counseling and vaccine prophylaxis before travel...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#8
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29682434/hypomania-risk-in-noninvasive-brain-stimulation
#9
REVIEW
Abhishek Gupta, Mahwish Adnan
Noninvasive brain stimulation, using electromagnetic waves (repetitive transcranial magnetic stimulation (rTMS)) and direct electrical current (transcranial direct current stimulation (tDCS)), is a new frontier in treating psychiatric maladies. While still being developed as viable treatment options, both options have had numerously reported side-effects, with hypomania being a significant concern during investigations. While there has been a relatively rare incidence of hypomania among rTMS/tDCS trials, it still posits an important issue regarding the safety of both treatment modalities...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29682309/australasian-society-for-hiv-viral-hepatitis-and-sexual-health-medicine-hiv-pre-exposure-prophylaxis-clinical-guidelines-update-april-2018
#10
EDITORIAL
Edwina Wright, Andrew Grulich, Katy Roy, Mark Boyd, Vincent Cornelisse, Darren Russell, Darryl O'Donnell, Bill Whittaker, Levinia Crooks, Iryna Zablotska
Daily use of coformulated tenofovir and emtricitabine for HIV pre-exposure prophylaxis (PrEP) by populations at high risk of HIV infection is now recommended in guidelines from the United States, Europe and Australia and globally through the 2015 WHO guidelines. These 2017 Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine's (ASHM) PrEP Guidelines are an updated adaptation of the 2014 US Centers for Disease Control's PrEP guidelines and are designed to: •Support the prescription of PrEP using forms of coformulated tenofovir and emtricitabine that have been registered in Australia by the Therapeutic Goods Administration and other bioequivalent generic drugs that are available in Australia through self-importation, private prescription or Australian PrEP clinical trials•Assist clinicians in the evaluation of patients who are seeking PrEP•Assist clinicians in commencing and monitoring patients on PrEP including PrEP dosing schedules, management of side-effects and toxicity, use of PrEP in pregnancy and in chronic hepatitis B infection and how to cease PrEP Daily PrEP with co-formulated tenofovir and emtricitabine, used continuously or for shorter periods of time, is recommended in these guidelines as a key HIV-prevention option for men who have sex with men (MSM), transgender men and women, heterosexual men and women, and people who inject drugs (PWID) at substantial risk of HIV acquisition...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681953/omega-3-fatty-acid-supplementation-improves-heart-rate-variability-in-obese-children
#11
Christoph Baumann, Ulla Rakowski, Reiner Buchhorn
Obese children and adolescents are at high risk of developing cardiovascular diseases later in life. We hypothesized that cardiovascular prophylaxis with omega-3 fatty acids could benefit them. In our study, 20 children and adolescents (mean body mass index percentile: 99.1; mean age: 11.0 years) underwent two ambulatory 24 h Holter electrocardiography (ECG) recordings (before and after at least 3 months of omega-3 fatty acid supplementation). Time domain heart rate variability (HRV) and heart rate (HR) were examined for these patients...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29681629/incidence-of-complications-in-dermatological-surgery-of-melanoma-and-non-melanoma-skin-cancer-in-patients-with-multiple-comorbidity-and-or-antiplatelet-anticoagulants-five-year-experience-in-our-hospital
#12
Lilia Arguello-Guerra, Estefanía Vargas-Chandomid, Jose Manuel Díaz-González, Silvia Méndez-Flores, Ana Ruelas-Villavicencio, Judith Domínguez-Cherit
Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Objective: To report the safety of surgery without suspending antithrombotic therapy and without oral antibiotic prophylaxis in dermatology surgery of patients with multiple comorbidities and polypharmacy...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29680398/plasma-and-peritoneal-fluid-concentrations-of-ceftriaxone-after-intravenous-and-intraperitoneal-administration-in-horses
#13
J M Alonso, R G Peccinini, M L Campos, T Y Nitta, T Y M Akutagawa, A P Crescencio, A L G Alves, C A Rodrigues, M J Watanabe, C A Hussni
Intraperitoneal (IP) use of antimicrobial agents may lead to therapeutic effects with better clinical results than intravenous (IV) administration. The aim of this study was to compare plasma and peritoneal fluid concentrations of ceftriaxone after IP and IV administration in horses, and to evaluate possible adverse effects. One group of five horses received 25mg/kg ceftriaxone diluted in 1L saline solution by IP catheter once daily for 5 days, while a second group of five horses received 25mg/kg ceftriaxone diluted in 250mL saline solution by IV injection once daily for 5days and 1L saline solution by IP catheter once daily for 5 days...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29679951/surgical-site-infection-rate-after-hemilaminectomy-and-laminectomy-in-dogs-without-perioperative-antibiotic-therapy
#14
Barbara A R Dyall, Hugo G Schmökel
OBJECTIVE:  The aim of this study was to retrospectively review the surgical site infection (SSI) rate in dogs undergoing laminectomies without perioperative antibiotics, and compare those data with the expected infection rate for clean surgical wounds in dogs undergoing similar procedures. METHODS:  This was a retrospective single-centre study composed of dogs that underwent hemilaminectomies or laminectomies for thoracolumbar disc herniation or lumbosacral disease during a 2-year period (during 2015 and 2016)...
April 21, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29679194/posterior-cranial-fossa-and-spinal-local-infections
#15
Federico Bianchi, Gianpiero Tamburrini
OBJECT: The aim of this paper is to review the current knowledge on the management of local infections in posterior cranial fossa (PCF) and spinal surgery; the center of our paper will be the diagnosis and management of infections of the wound, the subcutaneous tissue, and muscle strata. RESULTS AND CONCLUSIONS: Very few papers address the problem of local infections in posterior cranial fossa and spinal surgery. The largest amount of the literature data is indeed centered on how to deal with deep infections, CSF leak, and secondary meningitis or hardware infection...
April 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29679139/reality-of-the-emetogenic-level-of-irinotecan
#16
Maria-Angeles Garcia-Del-Barrio, Salvador Martin-Algarra, Azucena Aldaz Pastor
PURPOSE: To assess the emetogenic potential of different chemotherapy (CT) regimens in daily clinical practice in an outpatient setting. To optimize antiemetic prophylaxis if necessary METHODS: Prospective and retrospective review of the emetogenic potential of CT regimens used in adult patients in an outpatient setting RESULTS: We assess the chemotherapy-induced nausea and vomiting (CINV) of 50 different CT regimens used on 157 different patients in an outpatient setting. We found that the CT usually classified as highly emetogenic, including cisplatin and anthracycline-cyclophosphamide combination, had the higher incidence of CINV (37...
April 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#17
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29678845/the-use-of-type-i-collagen-cross-linked-c-telopeptide-ctx-1-as-a-biomarker-associated-with-the-formation-of-periprosthetic-ossifications-following-total-hip-joint-arthroplasty
#18
Paweł Łęgosz, Łukasz Pulik, Piotr Stępiński, Jakub Janowicz, Agnieszka Wirkowska, Andrzej Kotela, Sylwia Sarzyńska, Paweł Małdyk
The aim of this study was to determine the co-occurrence of heterotopic ossifications (HO) and elevated bone biomarkers level (urine type I collagen cross-linked C-telopeptide - CTX-1, serum alkaline phosphatase - ALP) and assess the effectiveness of pharmacological prophylaxis of HO. The study group consisted of (N=54) patients qualified for total hip arthroplasty. In N=19 (35%) patients new HO were formed (48th week vs to baseline). On baseline, the mean CTX-1 value in the HO (-) patients was 8.60+/-5.37 ug/mmol vs HO (+) 11...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678809/delayed-immune-reconstitution-after-allogeneic-transplantation-increases-the-risks-of-mortality-and-chronic-gvhd
#19
Nelli Bejanyan, Claudio G Brunstein, Qing Cao, Aleksandr Lazaryan, Xianghua Luo, Julie Curtsinger, Rohtesh S Mehta, Erica Warlick, Sarah A Cooley, Bruce R Blazar, Jeffrey S Miller, Daniel Weisdorf, John E Wagner, Michael R Verneris
Slow immune reconstitution is a major obstacle to the successful use of allogeneic hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is regarded as the gold standard, we evaluated the pace of immune reconstitution in 157 adult recipients of reduced-intensity conditioning followed by MSD peripheral blood HCT (n = 68) and compared these to recipients of umbilical cord blood (UCB; n = 89). At day 28, UCB recipients had fewer natural killer (NK) cells than MSD recipients, but thereafter, NK cell numbers (and their subsets) were higher in UCB recipients...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29678171/analysis-of-hepatic-transcriptome-demonstrates-altered-lipid-metabolism-following-lactobacillus-johnsonii-bs15-prevention-in-chickens-with-subclinical-necrotic-enteritis
#20
Xiaodan Qing, Dong Zeng, Hesong Wang, Xueqin Ni, Jing Lai, Lei Liu, Abdul Khalique, Kangcheng Pan, Bo Jing
BACKGROUND: Subclinical necrotic enteritis (SNE) widely outbreaks in chickens which inflicted growth-slowing, causing enormous social and economic burdens. To better understand the molecular underpinnings of SNE on lipid metabolism and explore novel preventative strategies against SNE, we studied the regulatory mechanism of a potential probiotic, Lactobacillus johnsonii BS15 on the lipid metabolism pathways involved in chickens with SNE. METHODS: One hundred eighty one-day-old chickens were randomly divided into three groups and arranged with basal diet (control and SNE group)...
April 20, 2018: Lipids in Health and Disease
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