keyword
https://read.qxmd.com/read/38537062/late-cytomegalovirus-disease-after-hematopoietic-cell-transplantation-significance-of-novel-transplantation-techniques
#1
JOURNAL ARTICLE
Alicja Sadowska-Klasa, Sezen Özkök, Hu Xie, Wendy M Leisenring, Danniel Zamora, Sachiko Seo, Jordan Sheldon, Stephanie J Lee, Keith R Jerome, Margaret L Green, Michael J Boeckh
Pre-emptive therapy (PET) and letermovir prophylaxis are effective in preventing CMV disease within the first 100 days after allogeneic hematopoietic cell transplantation (HCT) but are associated with late-onset CMV disease. We retrospectively examined the clinical manifestations, risk factors, prevention algorithm, and outcome of late CMV disease in CMV seropositive day 100 survivors transplanted between 2001-2017 (PET cohort) and 2018-2021 (letermovir cohort). There were 187 episodes of late CMV disease among 2469 day 100 survivors and the estimated cumulative incidence of first late CMV disease was 6...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536232/adapting-mhealth-interventions-prepmate-and-dot-diary-to-support-prep-retention-in-care-and-adherence-among-english-and-spanish-speaking-men-who-have-sex-with-men-and-transgender-women-in-the-united-states-formative-work-and-pilot-randomized-trial
#2
JOURNAL ARTICLE
Albert Y Liu, Cat-Dancing Alleyne, Susanne Doblecki-Lewis, Kimberly A Koester, Rafael Gonzalez, Janie Vinson, Hyman Scott, Susan Buchbinder, Thiago S Torres
BACKGROUND: A growing number of mobile health (mHealth) technologies are being developed to support HIV preexposure prophylaxis (PrEP) adherence and persistence; however, most tools have focused on men who have sex with men (MSM), and few are available in Spanish. To maximize the potential impact of these tools in reducing gender and racial/ethnic disparities and promoting health equity, mHealth tools tailored to Spanish-speaking people and transgender women are critically needed. OBJECTIVE: The aim of this study is to adapt and tailor 2 mHealth technologies, PrEPmate and DOT Diary, to support daily PrEP adherence and persistence among Spanish-speaking MSM and English- and Spanish-speaking transgender women and to evaluate the feasibility and acceptability of these tools...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536200/incidence-risk-factors-and-outcome-of-asymptomatic-central-nervous-system-involvement-in-adult-patients-with-acute-myeloid-leukemia
#3
JOURNAL ARTICLE
Marijana Virijevic, Nada Kraguljac-Kurtovic, Mirjana Mitrovic, Ljubomir Jakovic, Zoran Bukumuric, Nikola Pantic, Nikica Sabljic, Zlatko Pravdic, Mirjana Cvetkovic, Vesna Knezevic, Tijana Dragovic-Ivancevic, Irena Djunić, Jovan Rajic, Violeta Milosevic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic
Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic patients with CNS involvement might go undetected. The effect of CNS involvement on the AML disease course is not well defined, with conflicting results regarding clinical outcome. This study aimed to determine the incidence of asymptomatic CNS involvement in AML estimated by multiparametric flow cytometry of cerebrospinal fluid (MFC-CSF) at diagnosis, the related potential risk factors, and prognosis...
March 2024: Hematological Oncology
https://read.qxmd.com/read/38535882/single-dose-rifampicin-leprosy-chemoprophylaxis-for-household-contacts-in-kiribati-an-audit-of-a-combined-retrospective-and-prospective-approach
#4
JOURNAL ARTICLE
Patrick O Campbell, Temea Bauro, Erei Rimon, Eretii Timeon, Caitlin Bland, Nabura Ioteba, Nicholas M Douglas, Arturo Cunanan, Stephen T Chambers
Kiribati is a Pacific Island nation with a widely dispersed population and one of the highest rates of leprosy worldwide. Single-dose rifampicin post-exposure prophylaxis (SDR-PEP) of leprosy contacts has reduced new case detection rates in controlled trials. In 2018, an SDR-PEP programme was introduced in Kiribati that included screening and chemoprophylaxis of household contacts of leprosy cases retrospectively (2010-2017) and prospectively (2018-2022). We conducted a retrospective audit to determine the comprehensiveness, timeliness and feasibility of the SDR-PEP programme...
March 1, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535587/indoor-inactivation-of-sars-cov-2-virus-by-liquid-hyperoxygen
#5
JOURNAL ARTICLE
Giovanni Barco, Zumama Khalid, Alessandra Pulliero, Claudio Angelinetta, Ubaldo Prati, Alberto Izzotti
The possible future emergence of new SARS-CoV-2 virus variants pushes the development of new chemoprophylaxis protocols complementary to the unspecific and specific immune-prophylaxis measures currently used. The SARS-CoV-2 virus is particularly sensitive to oxidation, due to the relevant positive electrical charge of its spike protein used as a ligand for target cells. The present study evaluated the safety and efficacy of a new oxidant preparation, liquid hyperoxygen (IOL), to neutralize the SARS-CoV-2 virus...
March 11, 2024: Pathogens
https://read.qxmd.com/read/38535200/a-phase-i-iia-prospective-randomized-open-label-study-on-the-safety-and-efficacy-of-nebulized-liposomal-amphotericin-for-invasive-pulmonary-aspergillosis
#6
JOURNAL ARTICLE
Jesús Fortún, Elia Gómez-García de la Pedrosa, Alberto Martínez-Lorca, Patricia Paredes, Pilar Martín-Dávila, Alicia Gómez-López, María José Buitrago, Javier López-Jiménez, Francesca Gioia, Rosa Escudero, Maria Elena Alvarez-Alvarez, Cruz Soriano, Javier Moreno-García, Diana San Miguel, Noelia Vicente, Santiago Moreno
Although nebulized liposomal amphotericin B (NLAB) is being used in invasive pulmonary aspergillosis (IPA) prophylaxis, no clinical trial has shown its efficacy as a therapeutic strategy. NAIFI is the inaugural randomized, controlled clinical trial designed to examine the safety and effectiveness of NLAB (dosage: 25 mg in 6 mL, three times per week for 6 weeks) against a placebo, in the auxiliary treatment of IPA. Throughout the three-year clinical trial, thirteen patients (six NLAB, seven placebo) were included, with 61% being onco-hematological with less than 100 neutrophils/μL...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535126/current-methods-of-newborn-screening-follow-up-for-sickle-cell-disease-are-highly-variable-and-without-quality-assurance-results-from-the-enhance-study
#7
JOURNAL ARTICLE
Najibah Galadanci, Shannon Phillips, Alyssa Schlenz, Nataliya Ivankova, Julie Kanter
Newborn screening (NBS) for sickle cell disease (SCD) has significantly improved childhood survival but there are still gaps resulting in delayed care for affected infants. As a state-run program, there are no national quality assurance programs to ensure each state achieves consistent, reliable outcomes. We performed this qualitative study of NBS follow-up practices to better evaluate and understand the multi-level, state-specific processes of how each state's public health department delivers the NBS results to families, how/if they ensure affected infants are seen quickly by sickle cell specialists, and to determine the close-out processes used in each state...
March 8, 2024: International Journal of Neonatal Screening
https://read.qxmd.com/read/38534971/the-conundrum-of-cancer-associated-thrombosis-lesson-learned-from-two-intriguing-cases-and-literature-review
#8
Simona Laurino, Sabino Russi, Ludmila Carmen Omer, Alberto D'Angelo, Giovanni Bozza, Giuseppina Gallucci, Geppino Falco, Giandomenico Roviello, Anna Maria Bochicchio
The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for a comprehensive review of the thrombotic issue. A 75-year-old man with advanced rectal cancer treated with fluoropyrimidines suffered two catheter-related VTE events managed according to current guidelines. There was no indication for "extended" anticoagulant therapy for him, but during antithrombotic wash-out and fluoropyrimidines plus panitumumab regimen, he suffered a massive right coronary artery (RCA) thrombosis...
February 28, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534112/accelerating-therapeutics-development-during-a-pandemic-population-pharmacokinetics-of-the-long-acting-antibody-combination-azd7442-tixagevimab-cilgavimab-in-the-prophylaxis-and-treatment-of-covid-19
#9
JOURNAL ARTICLE
Lindsay E Clegg, Oleg Stepanov, Henning Schmidt, Weifeng Tang, Huixia Zhang, Chris Webber, Taylor S Cohen, Mark T Esser, Mats Någård
AZD7442 is a combination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies, tixagevimab and cilgavimab, developed for pre-exposure prophylaxis (PrEP) and treatment of coronavirus disease 2019 (COVID-19). Using data from eight clinical trials, we describe a population pharmacokinetic (popPK) model of AZD7442 and show how modeling of "interim" data accelerated decision-making during the COVID-19 pandemic. The final model was a two-compartmental distribution model with first-order absorption and elimination, including standard allometric exponents for the effect of body weight on clearance and volume...
March 27, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38533603/cascade-analysis-of-awareness-willingness-uptake-and-adherence-with-regard-to-prep-among-young-men-who-have-sex-with-men-ymsm-in-china-a-comparison-between-students-and-non-students
#10
JOURNAL ARTICLE
Yuanyuan Liu, Zhaoyu Cheng, Yidan Xian, Xuan Liu, Siyue Wei, Ju Ma, Jiageng Chen, Zhongdan Chen, Fengli Liu, Jie Yang, Maohe Yu, Changping Li, Zhuang Cui
INTRODUCTION: In China, young men who have sex with men (YMSM) are one of the groups most at risk of HIV/AIDS. The uptake of pre-exposure prophylaxis (PrEP) among YMSM has not been well documented. A cascade analysis of awareness, willingness, use and adherence with regard to PrEP was conducted separately among YMSM students and non-students. METHODS: From 20 October to 30 December 2021, all adolescents aged 16-24 years were selected for the study from among MSM recruited from 31 provincial administrative regions in mainland China...
March 27, 2024: HIV Medicine
https://read.qxmd.com/read/38533288/protective-effect-of-baclofen-on-ovarian-cystogenesis-and-morphine-induced-lipid-profile-change-in-female-rats
#11
JOURNAL ARTICLE
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani
INTRODUCTION: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. MATERIALS AND METHODS: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533196/dental-caries-in-children-with-sickle-cell-disease-and-its-association-with-the-use-of-hydroxyurea-and-penicillin-prophylaxis-in-dar-es-salaam
#12
JOURNAL ARTICLE
Irene Kida Minja, Evarist Mulyahela Wilson, Ferdinand M Machibya, Agnes Jonathan, Fortunata Cornel, Paschal Ruggajo, Julie Makani, Emmanuel Balandya
PURPOSE: This comparative study sets out to report dental caries status among individuals with Sickle Cell Disease (HbSS) against those with sickle cell trait (HbSA) and those without the disease (HbAA) as controls. The study further assessed the impact of penicillin chemoprophylaxis and hydroxyurea use on dental caries among Sickle Cell Disease participants. METHODS: This was a comparative cross-sectional study in which 93 children aged 30 to 60 months were recruited...
2024: Pediatric Health, Medicine and Therapeutics
https://read.qxmd.com/read/38533156/bidirectional-abo-mismatch-is-associated-with-elevated-mortality-in-hematopoietic-stem-cell-transplantation-insights-from-a-single-center-experience
#13
JOURNAL ARTICLE
Sidika Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Arif Ataberk Büyükyatıkçı, Meral Sönmezoğlu, Hasan Atilla Özkan
Background Hematopoietic stem cell transplantation (HSCT) is a promising therapy for various disorders and provides new opportunities for patients. ABO incompatibility in allogeneic HSCT (allo-HSCT) remains a topic of debate because of its potential impact on clinical outcomes. This study aimed to analyze the survival outcomes of patients who underwent ABO-incompatible HSCT and evaluate the occurrence of pure red cell aplasia. Methods This retrospective study included 20 patients who underwent ABO-incompatible HSCT...
February 2024: Curēus
https://read.qxmd.com/read/38533155/granulocyte-colony-stimulating-factor-g-csf-induced-aortitis-a-case-report
#14
Masahiro Ito, Masakazu Amari, Akiko Sato, Masahiro Hikichi
Pegylated granulocyte colony-stimulating factor (G-CSF), commonly used in chemotherapy-induced neutropenia, has been associated with rare instances of aortitis. This study describes a 67-year-old female patient with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2-positive breast cancer, undergoing chemotherapy with an epirubicin/cyclophosphamide (EC) regimen (epirubicin, cyclophosphamide) and pegylated G-CSF for neutropenia prophylaxis. Post-treatment, she developed symptoms including intermittent fever and severe arthralgia...
February 2024: Curēus
https://read.qxmd.com/read/38533141/the-effect-of-tranexamic-acid-with-or-without-tourniquet-on-blood-loss-in-total-knee-arthroplasty-at-a-community-hospital
#15
JOURNAL ARTICLE
Elise N Ketelaar, Michael Wagner, Adam Lorenzo, Robert Comrie, Carolina Restini, Grace D Brannan, Roger Corvasce, Saad Mohammad
Tourniquets have long been used in total knee arthroplasty due to the theoretical improvement of bleeding control, integration of cement-bone interface, visibility, and efficiency of the overall surgery. However, this has become increasingly disputed. Comparative studies in total knee arthroplasty employing chemical prophylaxis, i.e., tranexamic acid, have been conducted. This retrospective cohort study evaluated the effect of tranexamic with or without a tourniquet on mean blood loss, hemoglobin, and length of stay in total knee arthroplasty patients...
February 2024: Curēus
https://read.qxmd.com/read/38533126/innate-immune-response-of-rainbow-trout-erythrocytes-to-spinycterins-expressing-a-downsized-viral-fragment-of-viral-haemorrhagic-septicaemia-virus
#16
JOURNAL ARTICLE
S Puente-Marin, D Cazorla, V Chico, J Coll, M Ortega-Villaizan
Recent studies have reported on the importance of RBCs in fish responses to viral infections and DNA vaccines. Surface-displaying recombinant bacterins (spinycterins) are a safe and adaptable prototype for viral vaccination of fish and represent an alternative method of aquaculture prophylaxis, since have been reported to enhance fish immune response. We evaluated the innate immune response of rainbow trout ( Oncorhynchus mykiss ) red blood cells (RBCs), head kidney, and spleen to spinycterins expressing a fragment of the glycoprotein G of viral haemorrhagic septicemia virus (VHSV), one of the most devastating world-wide diseases in farmed salmonids...
April 15, 2023: Aquaculture
https://read.qxmd.com/read/38532939/safety-and-efficacy-of-recombinant-fusion-protein-linking-coagulation-factor-ix-with-albumin-rix-fp-in-previously-untreated-patients-with-hemophilia-b
#17
JOURNAL ARTICLE
Richard Lemons, Michael Wang, Julie Curtin, Lynda Mae Lepatan, Christoph Male, Flora Peyvandi, Mario von Depka Prondzinski, Rongrong Wang, William McKeand, Wilfried Seifert, Johannes Oldenburg
Introduction  Recombinant fusion protein linking coagulation factor IX (FIX) with albumin (rIX-FP) has been shown to be an effective, well-tolerated treatment for patients with severe hemophilia B who had previously received factor replacement therapy. This study investigated the safety and efficacy of rIX-FP in previously untreated patients (PUPs). Methods  Patients with moderately severe/severe hemophilia B (≤2% FIX) previously untreated with FIX replacement products received rIX-FP (25-75 IU/kg) prophylaxis weekly or on-demand treatment over ≥50 exposure days (EDs)...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532864/randomized-clinical-trial-of-aspirin-as-prophylaxis-for-thromboembolism-in-hip-arthroplasty
#18
JOURNAL ARTICLE
Raul Carneiro Lins, Epitacio Rolim, Yago Andrade Lima, Rodrigo Rodrigues de Sousa Moura
OBJECTIVE: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. METHODS: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking. RESULTS: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532451/moderate-to-vigorous-intensity-physical-activities-for-hemophilia-a-patients-during-low-dose-pharmacokinetic-guided-extended-half-life-factor-viii-prophylaxis
#19
JOURNAL ARTICLE
Chonlatis Srichumpuang, Arunothai Rakmanotham, Chatphatai Moonla, Darintr Sosothikul
BACKGROUND: Low-dose pharmacokinetic (PK)-guided extended half-life (EHL) factor VIII (FVIII) prophylaxis can reduce the bleeding risk in hemophilia A (HA) patients. An increase in physical activities for promoting musculoskeletal health may enhance the benefits of prophylactic therapy. OBJECTIVES: To determine the clinical impact of moderate- to vigorous-intensity physical activities in HA patients during low-dose PK-guided EHL FVIII prophylaxis. PATIENTS/METHODS: This prospective study enrolled patients with moderate/severe HA (baseline FVIII levels ≤ 5 IU/dL) who had received low-dose PK-guided EHL FVIII prophylaxis for ≥ 6 months...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38532395/providing-medication-for-opioid-use-disorder-and-hiv-pre-exposure-prophylaxis-at-syringe-services-programs-via-telemedicine-a-pilot-study
#20
JOURNAL ARTICLE
Mehri S McKellar, Andrea C Des Marais, Hillary Chen, Yujung Choi, Rebecca Lilly, Denae Ayers, Jesse Bennett, Lauren Kestner, Brian Perry, Stephanie Poley, Amy Corneli, Christina S Meade, Nidhi Sachdeva
BACKGROUND: People who inject drugs (PWID) are at high risk for opioid overdose and infectious diseases including HIV. We piloted PARTNER UP, a telemedicine-based program to provide PWID with medication for opioid use disorder (MOUD) with buprenorphine/naloxone (bup/nx) and oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine through two syringe services programs (SSP) in North Carolina. We present overall results from this project, including participant retention rates and self-reported medication adherence...
March 26, 2024: Harm Reduction Journal
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