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https://www.readbyqxmd.com/read/29781726/in-vitro-analysis-of-glucose-and-quercetin-effects-on-m-tor-and-nrf-2-expression-in-hepg2-cell-line-diabetes-and-cancer-connection
#1
Amir Yarahmadi, Fatemeh Khademi, Zohreh Mostafavi-Pour, Fatemeh Zal
Some types of cancers show a strong relationship with diabetes and play a central role in mortality in the patient population suffering from diabetes mellitus. In this study, HepG2 cells have been used to investigate the toxic effects of hyperglycemia and/or quercetin (Q) on mammalian target of rapamycin (m-TOR) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression as central molecules involved in cancer. HepG2 cells were cultured with different concentrations of glucose (5.5, 30, and 50 mM) and/or Q (25 µM) for 48 and 72 h...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29779873/short-term-intermittent-fasting-induces-long-lasting-gut-health-and-tor-independent-lifespan-extension
#2
James H Catterson, Mobina Khericha, Miranda C Dyson, Alec J Vincent, Rebecca Callard, Steven M Haveron, Arjunan Rajasingam, Mumtaz Ahmad, Linda Partridge
Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day fasted IF regime at the beginning of adulthood was sufficient to extend lifespan. This long-lasting, beneficial effect of early IF was not due to reduced fecundity. Starvation resistance and resistance to oxidative and xenobiotic stress were increased after IF...
May 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29778771/do-serum-markers-of-liver-fibrosis-vary-by-hcv-infection-in-patients-with-alcohol-use-disorder
#3
Arantza Sanvisens, Alvaro Muñoz, Ferran Bolao, Paola Zuluaga, Magí Farré, Inmaculada Jarrin, Jordi Tor, Roberto Muga
INTRODUCTION: HCV infection is frequent in patients with alcohol use disorder (AUD). Ethanol and hepatitis C have a synergistic effect that increases the risk of end-stage liver disease. We aimed to assess fibrosis of the liver in patients admitted to treatment of AUD. METHODS: Data were collected in two hospital units between 2000 and 2014. Liver fibrosis was assessed by serum biomarkers APRI, FIB-4 and Forns, and Advanced Liver Fibrosis (ALF) was defined if APRI > 1...
May 16, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29773572/hemostatic-efficacy-of-pathogen-inactivated-versus-untreated-platelets-a-randomized-controlled-trial
#4
Pieter F van der Meer, Paula F Ypma, Nan van Geloven, Joost A van Hilten, Rinie J van Wordragen-Vlaswinkel, Okke Eissen, Jaap J Zwaginga, MIchael Trus, Erik A M Beckers, Peter Te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J Norris, Raymond P Goodrich, Anneke Brand, Tor Hervig, Nancy M Heddle, Johanna G van der Bom, Jean-Louis H Kerkhoffs
Pathogen inactivation of platelet concentrates reduces the risk of blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen inactivated platelets using riboflavin and ultraviolet B illumination technology (intervention) compared to standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocytopenia. The primary outcome parameter was the proportion of transfusion treatment periods in which the patient had grade 2 or higher bleeding as defined by World Health Organization (WHO) criteria...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29771877/cholera-epidemic-lusaka-zambia-october-2017-may-2018
#5
Nyambe Sinyange, Joan M Brunkard, Nathan Kapata, Mazyanga Lucy Mazaba, Kunda G Musonda, Raymond Hamoonga, Muzala Kapina, Fred Kapaya, Lwito Mutale, Ernest Kateule, Francis Nanzaluka, James Zulu, Chileshe Lukwesa Musyani, Alison V Winstead, William W Davis, Hammad S N'cho, Nelia L Mulambya, Patrick Sakubita, Orbie Chewe, Sulani Nyimbili, Ezinne V C Onwuekwe, Nedghie Adrien, Anna J Blackstock, Travis W Brown, Gordana Derado, Nancy Garrett, Sunkyung Kim, Sydney Hubbard, Amy M Kahler, Warren Malambo, Eric Mintz, Jennifer Murphy, Rupa Narra, Gouthami G Rao, Margaret A Riggs, Nicole Weber, Ellen Yard, Khozya D Zyambo, Nathan Bakyaita, Namani Monze, Kennedy Malama, Jabbin Mulwanda, Victor M Mukonka
On October 6, 2017, an outbreak of cholera was declared in Zambia after laboratory confirmation of Vibrio cholerae O1, biotype El Tor, serotype Ogawa, from stool specimens from two patients with acute watery diarrhea. The two patients had gone to a clinic in Lusaka, the capital city, on October 4. Cholera cases increased rapidly, from several hundred cases in early December 2017 to approximately 2,000 by early January 2018 (Figure). In collaboration with partners, the Zambia Ministry of Health (MoH) launched a multifaceted public health response that included increased chlorination of the Lusaka municipal water supply, provision of emergency water supplies, water quality monitoring and testing, enhanced surveillance, epidemiologic investigations, a cholera vaccination campaign, aggressive case management and health care worker training, and laboratory testing of clinical samples...
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29765159/transition-to-chronic-pain-opportunities-for-novel-therapeutics
#6
Theodore J Price, Allan I Basbaum, Jacqueline Bresnahan, Jan F Chambers, Yves De Koninck, Robert R Edwards, Ru-Rong Ji, Joel Katz, Annemieke Kavelaars, Jon D Levine, Linda Porter, Neil Schechter, Kathleen A Sluka, Gregory W Terman, Tor D Wager, Tony L Yaksh, Robert H Dworkin
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29760544/ischemia-reperfusion-injury-in-porcine-intestine-viability-assessment
#7
Runar J Strand-Amundsen, Henrik M Reims, Finn P Reinholt, Tom E Ruud, Runkuan Yang, Jan O Høgetveit, Tor I Tønnessen
AIM: To investigate viability assessment of segmental small bowel ischemia/reperfusion in a porcine model. METHODS: In 15 pigs, five or six 30-cm segments of jejunum were simultaneously made ischemic by clamping the mesenteric arteries and veins for 1 to 16 h. Reperfusion was initiated after different intervals of ischemia (1-8 h) and subsequently monitored for 5-15 h. The intestinal segments were regularly photographed and assessed visually and by palpation. Intraluminal lactate and glycerol concentrations were measured by microdialysis, and samples were collected for light microscopy and transmission electron microscopy...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29756806/aging-and-the-strategic-use-of-context-to-control-prospective-memory-monitoring
#8
B Hunter Ball, Julie M Bugg
Monitoring the environment for the occurrence of prospective memory (PM) targets is a resource-demanding process that produces cost to ongoing activities. The current study investigated younger and older adults' ability to monitor strategically, which involves the heightening and relaxation of monitoring when it is contextually appropriate thereby affording conservation of limited-capacity attentional resources. Participants performed a lexical-decision task in which words or nonwords were presented in upper or lower locations of the screen...
May 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29754921/global-longitudinal-strain-corrected-by-rr-interval-is-a-superior-echocardiographic-predictor-of-outcome-in-patients-with-atrial-fibrillation
#9
Maria Dons, Jan Skov Jensen, Flemming Javier Olsen, Martina Chantal de Knegt, Thomas Fritz-Hansen, Ali Vazir, Tor Biering-Sørensen
BACKGROUND: Echocardiographic assessment of systolic and diastolic function during atrial fibrillation (AF) is challenging. This study evaluates the prognostic value of strain in patients with AF and suggests a novel approach on how to take into account the varying heart cycle lengths in AF. METHODS: Echocardiograms from 204 patients with AF during examination were analyzed offline. Patients with known heart failure (HF) were excluded. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754907/measures-of-left-atrial-function-predict-incident-atrial-fibrillation-in-stemi-patients-treated-with-primary-percutaneous-coronary-intervention
#10
Daniel Modin, Flemming Javier Olsen, Sune Pedersen, Jan Skov Jensen, Tor Biering-Sørensen
RATIONALE: Atrial fibrillation (AF) is the most common arrhythmia following acute myocardial infarction (AMI). Maximal left atrial (LA) volume is the only echocardiographic atrial parameter employed clinically to assess risk of AF development. OBJECTIVE: This study sought to determine the prognostic value of left atrial functional measures such as left atrial emptying fraction (LAEF) and left atrial expansion index (LAi) in predicting incident AF in the post-STEMI setting...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754533/the-validation-of-a-swimming-turn-wall-contact-time-measurement-system-a-touchpad-application-reliability-study
#11
Victoria Brackley, Kevin Ball, Elaine Tor
The effectiveness of the swimming turn is highly influential to overall performance in competitive swimming. The push-off or wall contact, within the turn phase, is directly involved in determining the speed the swimmer leaves the wall. Therefore, it is paramount to develop reliable methods to measure the wall-contact-time during the turn phase for training and research purposes. The aim of this study was to determine the concurrent validity and reliability of the Pool Pad App to measure wall-contact-time during the freestyle and backstroke tumble turn...
May 12, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29754260/robotic-lateral-oropharyngectomy-following-diagnostic-tonsillectomy-is-oncologically-safe-in-patients-with-high-risk-human-papillomavirus-related-squamous-cell-cancer
#12
Somiah Siddiq, David Cartlidge, Sarah Stephen, Hans P Sathasivam, Hannah Fox, James O'Hara, David Meikle, Muhammad Shahid Iqbal, Charles G Kelly, Max Robinson, Vinidh Paleri
PURPOSE: Diagnostic tonsillectomy is rarely an oncologic operation owing to close or positive margins. The standard of care is for further treatment to the primary site, typically with adjuvant radiotherapy. METHODS: 14 patients with close or positive margins following a diagnostic tonsillectomy underwent transoral robotic surgery (TORS) and lateral oropharyngectomy; five patients with the longest follow-up had their excision specimens examined with a step serial sectioning technique (SSS)...
May 12, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29752953/do-cells-sense-time-by-number-of-divisions
#13
Z Schuss, K Tor, D Holcman
Can the cell's perception of time be expressed through the length of the shortest telomere? To address this question, we analyze an asymmetric random walk that models telomere length for each division that can decrease by a fixed length a or, if recognized by a polymerase, it increases by a fixed length b ≫ a. Our analysis of the model reveals two phases, first, a determinist drift of the length toward a quasi-equilibrium state, and second, persistence of the length near an attracting state for the majority of divisions...
May 9, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29752309/sulfur-partitioning-between-glutathione-and-protein-synthesis-determines-plant-growth
#14
Anna Speiser, Marleen Silbermann, Yihan Dong, Stefan Haberland, Veli Vural Uslu, Shanshan Wang, Sajid A K Bangash, Michael Reichelt, Andreas J Meyer, Markus Wirtz, Ruediger Hell
Photoautotrophic organisms must efficiently allocate their resources between stress-response pathways and growth-promoting pathways to be successful in a constantly changing environment. In this study, we addressed the coordination of sulfur flux between biosynthesis of the reactive oxygen species scavenger glutathione (GSH) and protein translation as one example of a central resource allocation switch. We crossed the Arabidopsis (Arabidopsis thaliana) GSH synthesis depleted cadmium-sensitive cad2-1 mutant, which lacks glutamate Cys ligase, into the sulfite reductase (SiR) sir1-1 mutant, which suffers from a significantly decreased flux of sulfur into cysteine and is consequently retarded in growth...
May 11, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29750767/potential-for-more-rational-use-of-antibiotics-in-hospitalized-children-in-a-country-with-low-resistance-data-from-eight-point-prevalence-surveys
#15
Christian Magnus Thaulow, Dag Berild, Beate Horsberg Eriksen, Tor Åge Myklebust, Hege Salvesen Blix
BACKGROUND: Antimicrobial resistance (AMR) is low in Norway, but to prevent an increase the Norwegian Government has launched a National Strategy including a 30% reduction of broad-spectrum antibiotics (BSA) in hospitals within 2020. BSA are defined as second- and third-generation cephalosporins, carbapenems, piperacillin/tazobactam and quinolones. There are no recent studies of antibiotic use in Norwegian hospitalized children. AIM OF THE STUDY: To describe the use of antibiotics with emphasis on BSA in Norwegian hospitalized children and neonates in order to detect possibilities for optimization...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29743019/predictive-biomarkers-for-death-and-rehospitalization-in-comorbid-frail-elderly-heart-failure-patients
#16
Cristina Pacho, Mar Domingo, Raquel Núñez, Josep Lupón, Julio Núñez, Jaume Barallat, Pedro Moliner, Marta de Antonio, Javier Santesmases, Germán Cediel, Santiago Roura, M Cruz Pastor, Jordi Tor, Antoni Bayes-Genis
BACKGROUND: Heart failure (HF) is associated with a high rate of readmissions within 30 days post-discharge and in the following year, especially in frail elderly patients. Biomarker data are scarce in this high-risk population. This study assessed the value of early post-discharge circulating levels of ST2, NT-proBNP, CA125, and hs-TnI for predicting 30-day and 1-year outcomes in comorbid frail elderly patients with HF with mainly preserved ejection fraction (HFpEF). METHODS: Blood samples were obtained at the first visit shortly after discharge (4...
May 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29741427/time-course-of-subacute-pain-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma-versus-traditional-bilateral-tonsillectomy-in-adults-a-case-control-study
#17
Susanne Irene Scott, Anne Kathrine Østergaard Madsen, Niclas Rubek, Hani Ibrahim Channir, Henrik Kehlet, Christian von Buchwald
OBJECTIVE: To examine pain after Transoral Robotic Surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) versus traditional bilateral tonsillectomy in adults. METHODS: Pain evolvement was assessed in a prospective case-control design of 16 consecutive patients treated with TORS for early stage OPSCC versus 12 patients, who underwent bilateral tonsillectomy on suspicion of malignant disease. The TORS group received an optimized analgesia regime of preoperative oral celecoxib and gabapentin, intra- and postoperative high-dose intravenous dexamethasone, and regular postoperative oral contalgin, gabapentin, celecoxib, paracetamol and rescue morphine...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29738770/involvement-of-tor-signaling-motif-in-the-regulation-of-plant-autophagy
#18
Ora Son, Sunghan Kim, Dooil Kim, Yoon-Sun Hur, Jiyoung Kim, Choong-Ill Cheon
In our previous studies, we have demonstrated that a stretch of amino-acid sequences identified from Arabidopsis ribosomal S6 kinase 1 (AtS6K1) provided a plant version of the TOS (TOR-signaling) motif, mediating the interaction with the Raptor protein in the TOR (Target of Rapamycin) kinase complex. Here we report the presence of same element in Arabidopsis Autophagy related-13 (AtATG13) protein, which is a key component of the plant autophagy response. Its composition is nearly identical to that found in the AtS6K1 in the five-amino-acid core sequence, and the presence of this five-amino-acid sequence was found to be essential for its interaction with the Raptor protein...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29734044/tombusvirus-rna-replication-depends-on-the-tor-pathway-in-yeast-and-plants
#19
Jun-Ichi Inaba, Peter D Nagy
Similar to other (+)RNA viruses, tomato bushy stunt virus (TBSV) utilizes metabolites, lipids, membranes, and co-opted host factors during replication. The coordination of cell metabolism and growth with environmental cues is performed by the target of rapamycin (TOR) kinase in eukaryotic cells. In this paper, we find that TBSV replication partially inhibits TOR activity, likely due to recruitment of glycolytic enzymes to the viral replication compartment, which results in reduced ATP levels in the cytosol...
May 4, 2018: Virology
https://www.readbyqxmd.com/read/29732318/diagnostic-value-of-lingual-tonsillectomy-in-unknown-primary-head-and-neck-carcinoma-identification-after-a-negative-clinical-workup-and-positron-emission-tomography-computed-tomography
#20
Chad K Sudoko, Marc A Polacco, Benoit J Gosselin, Joseph A Paydarfar
Objective: Diagnostic rates of unknown primary head and neck carcinoma (UPHNC) using lingual tonsillectomy (LT) are highly variable. This study sought to determine the diagnostic value of LT in UPHNC identification using strict inclusion criteria and definitions to produce a more accurate estimate of diagnosis rate. Methods: In this retrospective chart review, records of patients who underwent LT for UPHNC were reviewed. Inclusion criteria included absence of suspicious findings on physical exam and positron emission tomography-computed tomography as well as negative biopsies after panendoscopy and palatine tonsillectomy...
2018: Frontiers in Oncology
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