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https://www.readbyqxmd.com/read/28526066/transovarial-transmission-of-denv-in-aedes-aegypti-in-the-amazon-basin-a-local-model-of-xenomonitoring
#1
Cristiano Fernandes da Costa, Ricardo Augusto Dos Passos, José Bento Pereira Lima, Rosemary Aparecida Roque, Vanderson de Souza Sampaio, Thais Bonifácio Campolina, Nágila Francinete Costa Secundino, Paulo Filemon Paolucci Pimenta
BACKGROUND: Transovarial transmission of dengue virus in Aedes spp. mosquitoes is considered an important mechanism for the maintenance of the virus in nature and may be implicated in the occurrence of outbreaks and epidemics of the disease. However, there are few studies involving transovarial transmission and viral vector monitoring as a surveillance tool and control strategy. The present study evaluated transovarial transmission of dengue virus in Aedes aegypti populations as a xenomonitoring strategy in municipalities of the Amazonas state...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28523879/in-memoriam-arnold-pieter-oranje-m-d-ph-d-august-7-1948-to-october-19-2016
#2
Tor Shwayder
No abstract text is available yet for this article.
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28520415/design-and-synthesis-of-soluble-and-cell-permeable-pi3k%C3%AE-inhibitors-for-long-acting-inhaled-administration
#3
Matthew W D Perry, Karin Björhall, Britta K Bonn, Johan Carlsson, Yunhua Chen, Anders Eriksson, Linda Fredlund, Hai'e Hao, Neil S Holden, Kostas Karabelas, Helena Lindmark, Feifei Liu, Nils Pemberton, Jens Petersen, Sandra Rodrigo Blomqvist, Reed W Smith, Tor Svensson, Ina Terstiege, Christian Tyrchan, Wenzhen Yang, Shuchun Zhao, Linda Öster
PI3Kδ is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesised to provide a powerful yet selective immunomodulatory effect that may be beneficial for the treatment of conditions such as asthma or rheumatoid arthritis. In this work we describe the identification of inhibitors based on a thiazolopyridone core structure and their subsequent optimisation for inhalation. The initially identified compound (13) had good potency and isoform selectivity but was not suitable for inhalation...
May 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28515443/development-of-a-whole-organism-platform-for-phenotype-based-analysis-of-igf1r-pi3k-akt-tor-action
#4
Chengdong Liu, Wei Dai, Yan Bai, Changfeng Chi, Yi Xin, Gen He, Kangsen Mai, Cunming Duan
Aberrant regulation of the insulin-like growth factor (IGF)/insulin (IIS)-PI3K-AKT-TOR signaling pathway is linked to major human diseases, and key components of this pathway are targets for therapeutic intervention. Current assays are molecular target- or cell culture-based platforms. Due to the great in vivo complexities inherited in this pathway, there is an unmet need for whole organism based assays. Here we report the development of a zebrafish transgenic line, Tg(igfbp5a:GFP), which faithfully reports the mitotic action of IGF1R-PI3K-Akt-Tor signaling in epithelial cells in real-time...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514141/subtype-specific-agonists-for-nmda-receptor-glycine-binding-sites
#5
Alex Maolanon, Rune Risgaard, Shuang-Yan Wang, Yoran Snoep, Athanasios Papangelis, Feng Yi, David Holley, Anne F Barslund, Niels Svenstrup, Kasper B Hansen, Rasmus Prætorius Clausen
A series of analogues based on serine as lead structure were designed and their agonist activities were evaluated at recombinant NMDA receptor subtypes (GluN1/2A-D) using two-electrode voltage-clamp (TEVC) electrophysiology. Pronounced variation in subunit-selectivity, potency, and agonist efficacy was observed in a manner that was dependent on the GluN2 subunit in the NMDA receptor. In particular, compounds 15a and 16a are potent GluN2C-specific superagonists at the GluN1 subunit with agonist efficacies of 398% and 308% compared to glycine...
May 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28513895/one-year-quality-of-life-and-functional-outcomes-of-transoral-robotic-surgery-for-carcinoma-of-unknown-primary
#6
Isa Ozbay, Ali Cemal Yumusakhuylu, Rishabh Sethia, Lai Wei, Matthew Old, Amit Agrawal, Theodoros Teknos, Enver Ozer
BACKGROUND: The purpose of this study was to assess the quality of life (QOL) outcomes in patients who underwent transoral robotic surgery (TORS) for carcinoma of unknown primary (CUP). METHODS: Twenty-nine patients with CUP were administered the Head and Neck Cancer Inventory (HNCI) prospectively to evaluate QOL preoperatively and postoperatively. RESULTS: There was statistically and clinically significant deterioration in 2 of 4 domains (eating and social disruption) in the immediate aftermath of TORS...
May 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28510433/gibbs-sampler-based-%C3%AE-dynamics-and-rao-blackwell-estimator-for-alchemical-free-energy-calculation
#7
Xinqiang Ding, Jonah Z Vilseck, Ryan Lee Hayes, Charles L Brooks
λ-dynamics is a generalized ensemble method for alchemical free energy calcula- tions. In traditional λ-dynamics, the alchemical switch variable λ is treated as a continuous variable ranging from 0 to 1 and an empirical estimator (∆Gˆ = -β(-1)ln[P(λ > λcutoff)/P (λ < 1-λcutoff)]) is utilized to approximate the free energy (∆G = -β(-1)ln[P (λ = 1)/P(λ = 0)]) based on λ trajectories, where the cutoff value of λcutoff is empirically chosen to be near 1. In the present paper, we describe an alternative formulation of λ-dynamics that utilizes the Gibbs sampler framework which we call Gibbs Sampler λ-dynamics (GSLD)...
May 16, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28505159/infectious-disease-ward-admission-positively-influences-p-jiroveci-pneumonia-pjp-outcome-a-retrospective-analysis-of-116-hiv-positive-and-hiv-negative-immunocompromised-patients
#8
Alessandra Ricciardi, Elisa Gentilotti, Luigi Coppola, Gaetano Maffongelli, Carlotta Cerva, Vincenzo Malagnino, Alessia Mari, Ambra Di Veroli, Federica Berrilli, Fabiana Apice, Nicola Toschi, David Di Cave, Saverio Giuseppe Parisi, Massimo Andreoni, Loredana Sarmati
P. jiroveci (Pj) causes a potentially fatal pneumonia in immunocompromised patients and the factors associated with a bad outcome are poorly understood. A retrospective analysis on Pj pneumonia (PjP) cases occurring in Tor Vergata University Hospital, Italy, during the period 2011-2015. The patients' demographic, clinical and radiological characteristics and the Pj genotypes were considered. The study population included 116 patients, 37.9% of whom had haematological malignancy or underwent haematological stem cell transplantation (HSCT), 22...
2017: PloS One
https://www.readbyqxmd.com/read/28504194/vaccination-with-recombinant-paramyosin-in-montanide-isa206-protects-against-schistosoma-japonicum-infection-in-water-buffalo
#9
Hannah Wei Wu, Zhi-Qiang Fu, Ke Lu, Sunthorn Pond-Tor, Rui Meng, Yang Hong, Kai Chu, Hao Li, Mario Jiz, Jin-Ming Liu, Ming Hou, Sangshin Park, Jiao-Jiao Lin, Jonathan D Kurtis
BACKGROUND: Schistosomiasis japonica is a zoonosis and presents significant public health problems in China and the Philippines. Vaccines targeting domestic animals constitute attractive control measures. METHODS: We conducted three vaccine trials to evaluate the protective efficacy of recombinant full-length paramyosin (rSj97) in water buffalo. Animals were immunized with 3 doses of rSj97 adjuvanted with ISA206 at 250μg/dose or 500μg/dose at 4wk intervals before challenge with 1000 Schistosoma japonicum cercariae...
May 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28498564/spatial-bayesian-latent-factor-regression-modeling-of-coordinate-based-meta-analysis-data
#10
Silvia Montagna, Tor Wager, Lisa Feldman Barrett, Timothy D Johnson, Thomas E Nichols
Now over 20 years old, functional MRI (fMRI) has a large and growing literature that is best synthesised with meta-analytic tools. As most authors do not share image data, only the peak activation coordinates (foci) reported in the article are available for Coordinate-Based Meta-Analysis (CBMA). Neuroimaging meta-analysis is used to (i) identify areas of consistent activation; and (ii) build a predictive model of task type or cognitive process for new studies (reverse inference). To simultaneously address these aims, we propose a Bayesian point process hierarchical model for CBMA...
May 12, 2017: Biometrics
https://www.readbyqxmd.com/read/28491073/regulation-of-translation-by-tor-eif4e-and-eif2%C3%AE-in-plants-current-knowledge-challenges-and-future-perspectives
#11
REVIEW
Ane Sesma, Carmen Castresana, M Mar Castellano
An important step in eukaryotic gene expression is the synthesis of proteins from mRNA, a process classically divided into three stages, initiation, elongation, and termination. Translation is a precisely regulated and conserved process in eukaryotes. The presence of plant-specific translation initiation factors and the lack of well-known translational regulatory pathways in this kingdom nonetheless indicate how a globally conserved process can diversify among organisms. The control of protein translation is a central aspect of plant development and adaptation to environmental stress, but the mechanisms are still poorly understood...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28486982/geographical-accessibility-and-duration-of-untreated-psychosis-distance-as-a-determinant-of-treatment-delay
#12
Erling Inge Kvig, Beate Brinchmann, Cathrine Moe, Steinar Nilssen, Tor Ketil Larsen, Knut Sørgaard
BACKGROUND: The duration of untreated psychosis is determined by both patient and service related factors. Few studies have considered the geographical accessibility of services in relation to treatment delay in early psychosis. To address this, we investigated whether treatment delay is co-determined by straight-line distance to hospital based specialist services in a mainly rural mental health context. METHODS: A naturalistic cross-sectional study was conducted among a sample of recent onset psychosis patients in northern Norway (n = 62)...
May 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28485577/site-selective-conjugation-of-native-proteins-with-dna
#13
Julie B Trads, Thomas Tørring, Kurt V Gothelf
Conjugation of DNA to proteins is increasingly used in academia and industry to provide proteins with tags for identification or handles for hybridization to other DNA strands. Assay technologies such as immuno-PCR and proximity ligation and the imaging technology DNA-PAINT require DNA-protein conjugates. In DNA nanotechnology, the DNA handle is exploited to precisely position proteins by self-assembly. For these applications, site-selective conjugation is almost always desired because fully functional proteins are required to maintain the specificity of antibodies and the activity of enzymes...
May 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28485389/egfr-dependent-tor-independent-endocycles-support-drosophila-gut-epithelial-regeneration
#14
Jinyi Xiang, Jennifer Bandura, Peng Zhang, Yinhua Jin, Hanna Reuter, Bruce A Edgar
Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem cells to produce enteroblasts (EBs) and enterocytes (ECs) that regenerate the gut. As EBs differentiate into ECs, they become postmitotic, but undergo extensive growth and DNA endoreplication. Here we report that EGFR/RAS/MAPK signalling is required and sufficient to drive damage-induced EB/EC growth. Endoreplication occurs exclusively in EBs and newborn ECs that inherit EGFR and active MAPK from fast-dividing progenitors...
May 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28484837/what-should-we-expect-from-robotic-surgery-for-second-primary-oropharyngeal-cancer
#15
Tuan-Jen Fang, Li-Ang Lee, Bing-Shan Huang, Chien-Yu Lin, Cheng-Lung Hsu, Joseph Tung-Chieh Chang, Tzu-Chen Yen, Chun-Ta Liao, Hui-Chen Chiang
The outcomes of second primary oropharyngeal cancer (SPOPC) may not be determined by oropharyngeal cancer but from the other index cancer as well. The management of (SPOPC) remains inconclusive and limited. Transoral robotic surgery (TORS) to maximize the functional outcomes without reducing oncologic effect is suggested as the primary treatment for selected oropharyngeal cancer. This study aimed to evaluate the feasibility and outcomes of TORS for the management of SPOPC. Patients who underwent TORS from January 2011 to June 2015 at a tertian referral center in Taiwan were recruited...
May 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28483912/an-in-vitro-torc1-kinase-assay-that-recapitulates-the-gtr-independent-glutamine-responsive-torc1-activation-mechanism-on-yeast-vacuoles
#16
Mirai Tanigawa, Tatsuya Maeda
Evolutionarily-conserved TOR complex 1 (TORC1) responds to nutrients, especially amino acids, to promote cell growth. In yeast Saccharomyces cerevisiae, various nitrogen sources activate TORC1 with different efficiencies although the mechanism remains elusive. Leucine, and perhaps other amino acids, was reported to activate TORC1 via the heterodimeric small GTPases Gtr1-Gtr2, the orthologs of the mammalian Rag GTPases. More recently, an alternative Gtr-independent TORC1 activation mechanism that may respond to glutamine was reported, although its molecular detail is not clear...
May 8, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28483302/preoperative-chemoradiotherapy-for-rectal-cancer-and-impact-on-outcomes-a-population-based-study
#17
Linn M Åsli, Tom B Johannesen, Tor Å Myklebust, Bjørn Møller, Morten Tandberg Eriksen, Marianne Grønlie Guren
BACKGROUND AND PURPOSE: Preoperative (chemo)radiotherapy ((C)RT) for rectal cancer is, in Norway, restricted to patients with cT4-stage or threatened circumferential resection margin. This nationwide population-based study assessed the use of preoperative (C)RT in Norway and its impact on treatment outcomes. PATIENTS AND METHODS: Data from The Norwegian Colorectal Cancer Registry were used to identify all stage I-III rectal cancers treated with major resection (1997-2011: n=9193)...
May 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28482501/metallic-powder-bed-based-3d-printing-of-cellular-scaffolds-for-orthopaedic-implants-a-state-of-the-art-review-on-manufacturing-topological-design-mechanical-properties-and-biocompatibility
#18
REVIEW
X P Tan, Y J Tan, C S L Chow, S B Tor, W Y Yeong
Metallic cellular scaffold is one of the best choices for orthopaedic implants as a replacement of human body parts, which could improve life quality and increase longevity for the people needed. Unlike conventional methods of making cellular scaffolds, three-dimensional (3D) printing or additive manufacturing opens up new possibilities to fabricate those customisable intricate designs with highly interconnected pores. In the past decade, metallic powder-bed based 3D printing methods emerged and the techniques are becoming increasingly mature recently, where selective laser melting (SLM) and selective electron beam melting (SEBM) are the two representatives...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481937/metabolomic-homeostasis-shifts-after-callus-formation-and-shoot-regeneration-in-tomato
#19
Alka Kumari, Kamalika Ray, Sadhna Sadhna, Arun Kumar Pandey, Yellamaraju Sreelakshmi, Rameshwar Sharma
Plants can regenerate from a variety of tissues on culturing in appropriate media. However, the metabolic shifts involved in callus formation and shoot regeneration are largely unknown. The metabolic profiles of callus generated from tomato (Solanum lycopersicum) cotyledons and that of shoot regenerated from callus were compared with the pct1-2 mutant that exhibits enhanced polar auxin transport and the shr mutant that exhibits elevated nitric oxide levels. The transformation from cotyledon to callus involved a major shift in metabolite profiles with denser metabolic networks in the callus...
2017: PloS One
https://www.readbyqxmd.com/read/28481722/ems-provider-perceptions-on-termination-of-resuscitation-in-a-large-urban-ems-system
#20
Katie L Tataris, Christopher T Richards, Leslee Stein-Spencer, Stephanie Ryan, Pete Lazzara, Joseph M Weber
OBJECTIVE: Despite the value of out-of-hospital Termination of Resuscitation (TOR) and the scientific evidence in favor of this practice, TOR has not been uniformly adopted or consistently practiced in EMS systems. Previous focus group studies have identified multiple barriers to implementation of out of hospital TOR but existing literature on EMS provider perceptions is limited. We sought to identify EMS providers' perceived barriers to performing out-of-hospital TOR in a large urban EMS system...
May 8, 2017: Prehospital Emergency Care
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