keyword
MENU ▼
Read by QxMD icon Read
search

TORS

keyword
https://www.readbyqxmd.com/read/29334671/glucosamine-promotes-osteoblast-proliferation-by-modulating-autophagy-via-the-mammalian-target-of-rapamycin-pathway
#1
Chen Lv, Lu Wang, Xiongbai Zhu, Wenjun Lin, Xin Chen, Zhengxiang Huang, Lintuo Huang, Shengwu Yang
Glucosamine is effective in the treatment of osteoarthritis; however, its effect on osteoporosis remains unclear. Decreased activity of osteoblasts is the main cause of osteoporosis. Here, we examined the effects of glucosamine on osteoblasts. The potential underlying mechanisms were explored. The results showed that glucosamine had a biphasic effect on the viability of hFOB1.19 osteoblasts. At low concentrations (<0.6 mM), glucosamine induced hFOB1.19 cell proliferation, whereas at high concentrations (>0...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29332340/imperatorin-shows-selective-antitumor-effects-in-sgc-7901-human-gastric-adenocarcinoma-cells-by-inducing-apoptosis-cell-cycle-arrest-and-targeting-pi3k-akt-m-tor-signalling-pathway
#2
J U Am, W J Gong, Y Su, Z B Mou
PURPOSE: The main purpose of the present study was to determine the anticancer properties of imperatorin - a naturally occurring coumarin compound - against SGC-7901 human gastric adenocarcinoma cells and the mouse fibroblast cell line 3T3 (normal cell line). METHODS: Imperatorin effects on apoptosis induction, cell cycle phase distribution and PI3K/Akt/m-TOR signalling pathways were studied. MTT cell viability assay examined the compound's cytotoxic potential, while inverted phase contrast microscopy and fluorescence microscopy techniques were used to study morphological changes induced in SGC-7901 cells by imperatorin...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29330317/trna-production-links-nutrient-conditions-to-the-onset-of-sexual-differentiation-through-the-torc1-pathway
#3
Yoko Otsubo, Tomohiko Matsuo, Akiko Nishimura, Masayuki Yamamoto, Akira Yamashita
Target of rapamycin (TOR) kinase controls cell growth and metabolism in response to nutrient availability. In the fission yeast Schizosaccharomyces pombe, TOR complex 1 (TORC1) promotes vegetative growth and inhibits sexual differentiation in the presence of ample nutrients. Here, we report the isolation and characterization of mutants with similar phenotypes as TORC1 mutants, in that they initiate sexual differentiation even in nutrient-rich conditions. In most mutants identified, TORC1 activity is downregulated and the mutated genes are involved in tRNA expression or modification...
January 12, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29329306/lifespan-extension-without-fertility-reduction-following-dietary-addition-of-the-autophagy-activator-torin1-in-drosophila-melanogaster
#4
Janet S Mason, Tom Wileman, Tracey Chapman
Autophagy is a highly conserved mechanism for cellular repair that becomes progressively down-regulated during normal ageing. Hence, manipulations that activate autophagy could increase lifespan. Previous reports show that manipulations to the autophagy pathway can result in longevity extension in yeast, flies, worms and mammals. Under standard nutrition, autophagy is inhibited by the nutrient sensing kinase Target of Rapamycin (TOR). Therefore, manipulations of TOR that increase autophagy may offer a mechanism for extending lifespan...
2018: PloS One
https://www.readbyqxmd.com/read/29329237/mtor-pathways-in-cancer-and-autophagy
#5
REVIEW
Mathieu Paquette, Leeanna El-Houjeiri, Arnim Pause
TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a central regulator of cell growth, proliferation and survival in response to nutritional status, growth factor, and stress signals. It plays a crucial role in coordinating the balance between cell growth and cell death, depending on cellular conditions and needs. As such, TOR has been identified as a key modulator of autophagy for more than a decade, and several deregulations of this pathway have been implicated in a variety of pathological disorders, including cancer...
January 12, 2018: Cancers
https://www.readbyqxmd.com/read/29327784/transoral-robotic-surgery-for-oropharyngeal-carcinoma-surgical-margins-and-oncologic-outcomes
#6
Eric J Moore, Kathryn M Van Abel, Daniel L Price, Christine M Lohse, Kerry D Olsen, Ryan S Jackson, Eliot J Martin
BACKGROUND: This study presents oncologic outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal squamous cell carcinoma (SCC). METHODS: Three hundred fourteen patients undergoing TORS ± adjuvant therapy for oropharyngeal SCC from May 1, 2007, to May 31, 2015, are analyzed. RESULTS: Median follow-up was 3.3 years (interquartile range [IQR] 1.8-5.3 years; range 1 day to 9.3 years). Estimated locoregional recurrence-free survival, distant metastasis-free survival (DMFS), overall survival (OS), and cancer-specific survival (CSS) rates (95% confidence interval [CI] number still at risk) at 5 years after surgery were 92% (88-95; 92), 90% (86-94; 92), 86% (82-92; 98), and 94% (91-97; 98), respectively...
January 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/29327731/transoral-robotic-surgery-in-eagle-s-syndrome-our-experience-on-four-patients
#7
D H Kim, Y H Lee, D Cha, S H Kim
Eagle's syndrome is characterised by focal pain in the tonsillar fossa on wide mouth opening or head rotation and various accompanying symptoms. While the syndrome is difficult to diagnose, shortening the styloid process via a transoral or transcervical surgical approach has been shown to be the most effective treatment. The aim of this article was to document our experience with a transoral robotic approach to treat Eagle's syndrome and to present the outcomes of four patients. We reviewed the cases of four patients with Eagle's syndrome who underwent transoral robotic surgery (TORS)...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29318646/improving-the-validity-of-script-concordance-testing-by-optimising-and-balancing-items
#8
Michael Sh Wan, Elina Tor, Judith Nicky Hudson
BACKGROUND: A script concordance test (SCT) is a modality for assessing clinical reasoning. Concerns had been raised about the plausible validity threat to SCT scores if students deliberately avoided the extreme answer options to obtain higher scores. The aims of the study were firstly to investigate whether students' avoidance of the extreme answer options could result in higher scores, and secondly to determine whether a 'balanced approach' by careful construction of SCT items (to include extreme as well as median options as model responses) would improve the validity of an SCT...
January 9, 2018: Medical Education
https://www.readbyqxmd.com/read/29316751/-mechanism-of-action-for-oligomeric-proanthocyaniclins-in-pava-qnat-induced-acute-lung-injury
#9
P Liu, Y S Zhou, Y L Qin, L Li, Y Liu, B Xu, K Huang, C C Ji, F Lin, Y G Wang, K Li, S H Chen, L F Shao, J S Mu
Objective: The present study was designed to evaluate the protective effects of oligomeric proanthocyanidins (OPC) in mice exposed to paraquat (PQ) , and to explore the molecular mechanism. Methods: Four experimental groups were designed. CONTROL GROUP: 10 BALB/c mice were intraperitoneally injected with normal saline) . PQ group: 10 BALB/c mice were intraperitoneally injected with PQ (100 mg/kg) . PQ+OPC group: 10 BALB/c mice were administered with OPC (100 mg/kg) for 1 h before PQ (100 mg/kg) expo-sure...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29315809/analysis-of-vibrio-seventh-pandemic-island-ii-and-novel-genomic-islands-in-relation-to-attachment-sequences-among-a-wide-variety-of-vibrio-cholerae-strains
#10
Tuan Hai Nguyen, Tho Duc Pham, Naomi Higa, Hanako Iwashita, Taichiro Takemura, Makoto Ohnishi, Kouichi Morita, Tetsu Yamashiro
Vibrio cholerae O1 El Tor, the pathogen responsible for the current cholera pandemic became pathogenic by acquiring virulent factors including Vibrio seventh pandemic islands (VSP)-I and -II. Diversity of VSP-II are well recognized, however, studies addressing attachment sequence left (attL) sequences of VSP-II are few. In this report, a wide variety of V. cholerae strains were analyzed for the structure and distribution of VSP-II in relation to their attachment sequences. Of 188 V. cholerae strains analyzed, 81% (153/188) strains carried VSP-II, of those, typical VSP-II, and a short variant was found in 36% (55/153), and 63% (96/153), respectively...
January 8, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29306940/preliminary-characterization-of-el-tor-vibriophage-m4
#11
Sayani Das, Amar N Ghosh
AIMS: The aim of the present study is the preliminary characterization of an El Tor vibriophage M4 (ATCC 51352-B4). METHODS: We studied the growth characteristics and sustainability of this phage under various stresses like temperature, pH, and UV. The phage morphology and phage genome were also examined using electron microscopy. RESULTS: Sustainability studies showed that the phage is more stable in acidic conditions, which is very uncommon among vibriophages...
January 6, 2018: Intervirology
https://www.readbyqxmd.com/read/29306771/stage-specific-incidence-and-survival-of-breast-cancer-in-norway-the-implications-of-changes-in-coding-and-classification-practice
#12
Inger Kristin Larsen, Tor Åge Myklebust, Tom Børge Johannesen, Bjørn Møller, Solveig Hofvind
To describe the association between coding and classification practices and observed stage-specific incidence and survival trends in Norway over time. We identified all women diagnosed with invasive breast cancer in the period between 1980 and 2015. Changes in the coding and classification of breast cancer in the study period were described, and stage-specific incidence rates and relative survival were calculated. A total of 90 362 women were diagnosed with primary breast cancer, stage I-IV, or unknown stage, in the study period...
January 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29305994/impaired-intestinal-immune-barrier-and-physical-barrier-function-by-phosphorus-deficiency-regulation-of-tor-nf-%C3%AE%C2%BAb-mlck-jnk-and-nrf2-signalling-in-grass-carp-ctenopharyngodon-idella-after-infection-with-aeromonas-hydrophila
#13
Kang Chen, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
In aquaculture, the occurrence of enteritis has increased and dietary nutrition is considered as one of the major strategies to solve this problem. In the present study, we assume that dietary phosphorus might enhance intestinal immune barrier and physical barrier function to reduce the occurrence of enteritis in fish. To test this assumption, a total of 540 grass carp (Ctenopharyngodon idella) were investigated by feeding graded levels of available phosphorus (0.95-8.75 g/kg diet) and then infection with Aeromonas hydrophila...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29304332/to-grow-or-not-to-grow-tor-and-snrk2-coordinate-growth-and-stress-response-in-arabidopsis
#14
Christina L Rosenberger, Jie Chen
For optimal growth, plants must tightly control the switch between stress responses and regrowth upon restoration of favorable conditions. In this issue of Molecular Cell, Wang et al. (2017) reveal that reciprocal regulation of growth-promoting TOR and stress-activated SnRK2 facilitates plant adaptation to environmental variations.
January 4, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29303488/small-intestinal-ischemia-and-reperfusion-bioimpedance-measurements
#15
Runar James Strand-Amundsen, Christian Tronstad, Havard Kalvoy, Tom Erik Ruud, Jan Olav Hogetveit, Orjan Grottem Martinsen, Tor Inge Tønnessen
Trans-intestinal bioimpedance measurements have previously been used to investigate changes in electrical parameters during 6 hours of ischemia in the small intestine. Knowledge is lacking regarding the time course of trans-intestinal bioimpedance parameters during reperfusion. As reperfusion is an important part in the clinical treatment of intestinal ischemia, we need to know how it affects the bioimpedance measurements. Approach: We performed bioimpedance measurements, using a two-electrode setup on selected segments of the jejunum in 15 pigs...
January 5, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29298526/comparison-of-radiofrequency-and-transoral-robotic-surgery-in-obstructive-sleep-apnea-syndrome-treatment
#16
Engin Aynacı, Murat Karaman, Burak Kerşin, Mahmut Ozan Fındık
INTRODUCTION: Radiofrequency tissue ablation (RFTA) and transoral robotic surgery (TORS) are the methods used in OSAS surgery. We also aimed to compare the advantages and disadvantages of RF and TORS as treatment methods applied in OSAS patients in terms of many parameters, especially apnea hypopnea index (AHI). MATERIALS AND METHODS: Patients were classified by performing a detailed examination and evaluation before surgery. 20 patients treated with anterior palatoplasty and uvulectomy -/+ tonsillectomy + RFTA (17 males, 3 females) and 20 patients treated with anterior palatoplasty and uvulectomy -/+  tonsillectomy + TORS (16 males, 4 females) were included in the study...
January 3, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29291576/lithium-promotes-the-production-of-reactive-oxygen-species-via-gsk-3%C3%AE-tsc2-tor-signaling-in-the-gill-of-zebrafish-danio-rerio
#17
Dongwu Liu, Lili Gao, Zhuangzhuang Zhang, Shiyi Tao, Qiuxiang Pang, Ao Li, Hongkuan Deng, Hairui Yu
In this study, the mechanism that lithium (Li) promotes the production of reactive oxygen species (ROS) via the glycogen synthase kinase-3β (GSK-3β)/tuberous sclerosis complex 2 (TSC2)/target of rapamycin (TOR) signaling was investigated in the gill of zebrafish (Danio rerio). After the zebrafish were treated by 25 and 50 mg/L Li+, the mRNA expression of GSK-3β and TSC2 was inhibited, but the expression of TOR was induced in the gill of zebrafish. The levels of hydrogen peroxide (H2O2), superoxide anion (O2·-), and hydroxy radical (·OH) as well as the activity of superoxide dismutase (SOD) were increased, while the activities of catalase (CAT), glutathione peroxidase (GSH-PX), and peroxidase (POD) were decreased by 25 and 50 mg/L Li+ treatments...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29290610/reciprocal-regulation-of-the-tor-kinase-and-aba-receptor-balances-plant-growth-and-stress-response
#18
Pengcheng Wang, Yang Zhao, Zhongpeng Li, Chuan-Chih Hsu, Xue Liu, Liwen Fu, Yueh-Ju Hou, Yanyan Du, Shaojun Xie, Chunguang Zhang, Jinghui Gao, Minjie Cao, Xiaosan Huang, Yingfang Zhu, Kai Tang, Xingang Wang, W Andy Tao, Yan Xiong, Jian-Kang Zhu
As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases...
December 27, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29288427/comparative-wgbs-identifies-genes-that-influence-non-ripe-phenotype-in-tomato-epimutant-colourless-non-ripening
#19
Weiwei Chen, Zhiming Yu, Junhua Kong, Hui Wang, Yichen Li, Mei Zhao, Xiaohong Wang, Qianqian Zheng, Nongnong Shi, Pengcheng Zhang, Silin Zhong, Paul Hunter, Mahmut Tör, Yiguo Hong
Whole-genome bisulfite sequencing (WGBS) allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals. This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation. However, naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define. In tomato, fruit development and ripening are a complex process that involves epigenetic control...
December 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29285332/correlations-between-dental-malocclusions-ocular-motility-and-convergence-disorders-a-cross-sectional-study-in-growing-subjects
#20
P Bollero, M R Ricchiuti, G Laganà, G DI Fusco, R Lione, P Cozza
Objective: The purpose of the study was to analyze the association between dento-skeletal malocclusions, ocular motility, and convergence disorders in growing subjects. Materials and methods: 84 subjects (49 males, 35 females) with a mean age of 7.3±1.7 years were enrolled in a screening procedure for celiac disease at the Department of Gastroenterology of the University of Rome "Tor Vergata". Each child underwent an orthodontic, orthoptic, and ophtalmological examination...
July 2017: Oral & Implantology
keyword
keyword
23862
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"