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https://www.readbyqxmd.com/read/28816596/expression-profiling-of-development-related-genes-in-rice-plants-ectopically-expressing-attor
#1
Achala Bakshi, Mazahar Moin, Raju Datla, P B Kirti
Expression analysis of genes associated with development at different growth stages such as shoot apical meristem (SAM), root apical meristem (RAM), shoot and root tissues 10 DAG, flowers and grains of two high expression transgenic lines of rice ectopically expressing AtTOR revealed the involvement of AtTOR in transcriptional regulation of these genes. We have observed that in the SAM of these two selected lines, TR-2.24 and TR-15.1, OsFON1 and OsFON4 (orthologs of AtCLV1 and AtCLV3, respectively), OsKNOX2, OsKNOX3 and OsWOX3 became up-regulated...
August 17, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28812692/gene-flow-from-domesticated-escapes-alters-the-life-history-of-wild-atlantic-salmon
#2
Geir H Bolstad, Kjetil Hindar, Grethe Robertsen, Bror Jonsson, Harald Sægrov, Ola H Diserud, Peder Fiske, Arne J Jensen, Kurt Urdal, Tor F Næsje, Bjørn T Barlaup, Bjørn Florø-Larsen, Håvard Lo, Eero Niemelä, Sten Karlsson
Interbreeding between domesticated and wild animals occurs in several species. This gene flow has long been anticipated to induce genetic changes in life-history traits of wild populations, thereby influencing population dynamics and viability. Here, we show that individuals with high levels of introgression (domesticated ancestry) have altered age and size at maturation in 62 wild Atlantic salmon Salmo salar populations, including seven ancestral populations to breeding lines of the domesticated salmon. This study documents widespread changes to life-history traits in wild animal populations following gene flow from selectively bred, domesticated conspecifics...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812400/new-benzodiazepine-and-z-hypnotic-users-and-disability-pension-an-eight-year-nationwide-observational-follow-up-study
#3
Ingunn F Tvete, Trine Bjørner, Tor Skomedal
OBJECTIVE: To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. DESIGN: Prescription register study. SETTING: Norwegian nationwide prescriptions socio-economic and disability status data. METHODS: Cox regression analyses. SUBJECTS: New benzodiazepine or Z-hypnotic users. MAIN OUTCOME MEASURE: Time to receive disability pension given benzodiazepine or Z-hypnotic use or both...
August 16, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28811665/optimization-of-storage-temperature-for-retention-of-undifferentiated-cell-character-of-cultured-human-epidermal-cell-sheets
#4
Catherine J Jackson, Sjur Reppe, Jon R Eidet, Lars Eide, Kim A Tønseth, Linda H Bergersen, Darlene A Dartt, May Griffith, Tor P Utheim
Cultured epidermal cell sheets (CES) containing undifferentiated cells are useful for treating skin burns and have potential for regenerative treatment of other types of epithelial injuries. The undifferentiated phenotype is therefore important for success in both applications. This study aimed to optimize a method for one-week storage of CES for their widespread distribution and use in regenerative medicine. The effect of storage temperatures 4 °C, 8 °C, 12 °C, 16 °C, and 24 °C on CES was evaluated...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810702/the-nutrient-transceptor-pka-pathway-functions-independently-of-tor-and-responds-to-leucine-and-gcn2-in-a-tor-independent-manner
#5
Michaela Conrad, Harish Nag Kankipati, Marlies Kimpe, Griet Van Zeebroeck, Zhiqiang Zhang, Johan M Thevelein
Two nutrient-controlled signalling pathways, the PKA and TOR pathway, play a major role in nutrient regulation of growth as well as growth-correlated properties in yeast. The relationship between the two pathways is not well understood. We have used Gap1 and Pho84 transceptor-mediated activation of trehalase and phosphorylation of fragmented Sch9 as a read-out for rapid nutrient activation of PKA or TORC1, respectively. We have identified conditions in which L-citrulline-induced activation of Sch9 phosphorylation is compromised, but not activation of trehalase: addition of the TORC1 inhibitor, rapamycin and low levels of L-citrulline...
August 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28808016/hydrodynamics-of-microbial-filter-feeding
#6
Lasse Tor Nielsen, Seyed Saeed Asadzadeh, Julia Dölger, Jens H Walther, Thomas Kiørboe, Anders Andersen
Microbial filter feeders are an important group of grazers, significant to the microbial loop, aquatic food webs, and biogeochemical cycling. Our understanding of microbial filter feeding is poor, and, importantly, it is unknown what force microbial filter feeders must generate to process adequate amounts of water. Also, the trade-off in the filter spacing remains unexplored, despite its simple formulation: A filter too coarse will allow suitably sized prey to pass unintercepted, whereas a filter too fine will cause strong flow resistance...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28805486/cop1-integrates-light-signals-to-rop2-for-cell-cycle-activation
#7
Wenguo Cai, Xiaojuan Li, Yanlin Liu, Yaowei Wang, Yue Zhou, Tongda Xu, Yan Xiong
The exquisite regulation of cell division at the shoot apex according to the external environmental cues enables plants to adapt the ever-changing environment. We have recently shown that light direct signaling and carbohydrate (sugar) energy signaling are both essential for the activation of cell division at the shoot apex. Light is converted to auxin signal to activate small GTPase 2 (ROP2). Subsequently, the activated ROP2 directly interacts with Target of Rapamycin (TOR) protein kinase, a pivotal regulator of cell division, to promotes its kinase activity...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28803921/molecular-evidence-of-apatococcus-including-a-fuscideae-sp-nov-as-photobiont-in-the-genus-fuscidea
#8
Martina Zahradníková, Heidi L Andersen, Tor Tønsberg, Andreas Beck
The knowledge of the taxonomy and classification of algae (including lichenized) has recently increased rapidly, but there are still many gaps. We aimed to 1) identify the Fuscidea photobionts by locating their taxonomic positions in the green algal classification, and 2) to resolve their interspecific relationships. The lichenized algae were examined based on morphological observations of axenic isolates as well as molecular studies of 18S and ITS nrDNA sequences. Analysis of the secondary structure of the ITS2 operon complemented these investigations...
June 29, 2017: Protist
https://www.readbyqxmd.com/read/28801386/gender-differences-in-infant-survival-a-secondary-data-analysis-in-rural-north-india
#9
Ranadip Chowdhury, Sunita Taneja, Sarmila Mazumder, Nita Bhandari, Tor A Strand
OBJECTIVE: To examine gender differences in infant survival on the first day of life, in the first week of life, and in the neonatal and post-neonatal periods by socio-demographic and economic variables. DESIGN: Secondary data analysis was performed on data from a cluster randomised trial on the effect of implementation of the Integrated Management of Neonatal and Childhood Illness programme, India. SETTINGS: The study setting was Palwal and Faridabad, districts of Haryana, a state in North India...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800204/comparison-of-robotic-and-coblation-tongue-base-resection-for-obstructive-sleep-apnea
#10
Chi Sang Hwang, Jin Won Kim, Jin Woong Kim, Eun Jung Lee, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
OBJECTIVES: To compare the efficacy and safety of transoral robotic surgery (TORS) with endoscope-guided coblation tongue base resection. DESIGN: Retrospective case-control study. SETTING: University-based tertiary care medical center. PARTICIPANTS: OSA patients who underwent endoscope-guided tongue base coblation resection or TORS in combination with lateral pharyngoplasty at a single institution in South Korea between April 2013 and December 2016 were investigated...
August 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28797451/post-operative-therapy-following-transoral-robotic-surgery-for-unknown-primary-cancers-of-the-head-and-neck
#11
Sapna A Patel, Aarthi Parvathaneni, Upendra Parvathaneni, Jeffrey J Houlton, Ron J Karni, Jay J Liao, Neal D Futran, Eduardo Méndez
OBJECTIVES: Our primary objective is to describe the post- operative management in patients with an unknown primary squamous cell carcinoma of the head and neck (HNSCC) treated with trans-oral robotic surgery (TORS). MATERIALS & METHODS: We conducted a retrospective multi-institutional case series including all patients diagnosed with an unknown primary HNSCC who underwent TORS to identify the primary site from January 1, 2010 to June 30, 2016. We excluded those with recurrent disease, ≤6months of follow up from TORS, previous history of radiation therapy (RT) to the head and neck, or evidence of primary tumor site based on previous biopsies...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797004/-lanthanic-presentation-in-first-episode-psychosis-predicts-long-service-delay-the-challenge-of-detecting-masked-psychosis
#12
Erling Inge Kvig, Beate Brinchmann, Cathrine Moe, Steinar Nilssen, Tor Ketil Larsen, Knut Sørgaard
BACKGROUND/AIMS: Studies of pathways to care in first-episode psychosis have documented a substantial treatment delay occurring after patients enter mental health services. An initial presentation with neurotic rather than psychotic symptoms is common in first-episode psychosis. The term "lanthanic patient" has been used to refer to patients presenting with a reason for help-seeking that is unrelated to the underlying pathology. The aim of this study is to explore whether a lanthanic presentation is related to prolonged service delay...
August 11, 2017: Psychopathology
https://www.readbyqxmd.com/read/28792540/antibiotics-resistance-in-el-tor-vibrio-cholerae-01-isolated-during-cholera-outbreaks-in-mozambique-from-2012-to-2015
#13
Liliana Candida Dengo-Baloi, Cynthia Amino Semá-Baltazar, Lena Vania Manhique, Jucunu Elias Chitio, Dorteia Luísa Inguane, José Paulo Langa
RATIONALE: Mozambique has recorded cyclically epidemic outbreaks of cholera. Antibiotic therapy is recommended in specific situations for management and control of cholera outbreaks. However, an increase in resistance rates to antibiotics by Vibrio cholerae has been reported in several epidemic outbreaks worldwide. On the other hand, there are few recent records of continuous surveillance of antibiotics susceptibility pattern of V. cholerae in Mozambique. GOALS: The purpose of this study was to evaluate antibiotics resistance pattern of Vibrio cholerae O1 Ogawa isolated during Cholera outbreaks in Mozambique to commonly used antibiotics...
2017: PloS One
https://www.readbyqxmd.com/read/28783755/snrk1-activates-autophagy-via-the-tor-signaling-pathway-in-arabidopsis-thaliana
#14
Junmarie Soto-Burgos, Diane C Bassham
Autophagy is a degradation process in which cells break down and recycle their cytoplasmic contents when subjected to environmental stress or during cellular remodeling. The Arabidopsis thaliana SnRK1 complex is a protein kinase that senses changes in energy levels and triggers downstream responses to enable survival. Its mammalian ortholog, AMPK, and yeast ortholog, Snf-1, activate autophagy in response to low energy conditions. We therefore hypothesized that SnRK1 may play a role in the regulation of autophagy in response to nutrient or energy deficiency in Arabidopsis...
2017: PloS One
https://www.readbyqxmd.com/read/28783214/punch-and-scoop-technique-for-removing-pilomatricoma
#15
Eric L Maranda, Farhaad Riyaz, Tor Shwayder
Pilomatricomas are benign calcifying neoplasms derived from follicle matrix cells. Standard treatment for pilomatricomas involves complete surgical excision, with an overall low rate of recurrence. We discuss a simple alternative surgical technique that allows for removal of the lesion with less residual defect than complete excision.
August 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28782298/transoral-robotic-surgery-for-tonsillar-cancer-addressing-the-contralateral-tonsil
#16
Peter T Dziegielewski, Brian J Boyce, Matthew Old, Theodoros N Teknos, Amit Agrawal, Hafiz Patwa, Enver Ozer
BACKGROUND: The purpose of this study is to determine the incidence and risk factors for bilateral tonsillar cancers treated with transoral robotic surgery (TORS) and to determine the morbidity of the procedure. METHODS: Patients undergoing TORS for known tonsillar cancer were retrospectively reviewed. Perioperative variables and surgical outcomes were analyzed to determine predictive factors for bilateral disease and morbidity rates. RESULTS: Seventy-nine consecutive patients with tonsillar cancers underwent primary TORS radical tonsillectomy...
August 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28781232/multivalent-recruitment-of-human-argonaute-by-gw182
#17
Elad Elkayam, Christopher R Faehnle, Marjorie Morales, Jingchuan Sun, Huilin Li, Leemor Joshua-Tor
In miRNA-mediated gene silencing, the physical interaction between human Argonaute (hAgo) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. GW182 can interact with hAgo via three of the GW/WG repeats in its Argonaute-binding domain: motif-1, motif-2, and the hook motif. The structure of hAgo1 in complex with the hook motif of hGW182 reveals a "gate"-like interaction that is critical for GW182 docking into one of hAgo1's tryptophan-binding pockets. We show that hAgo1 and hAgo2 have a single GW182-binding site and that miRNA binding increases hAgo's affinity to GW182...
July 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28781084/crystal-structure-and-regulation-of-the-citrus-pol-iii-repressor-maf1-by-auxin-and-phosphorylation
#18
Adriana Santos Soprano, Priscila Oliveira de Giuseppe, Hugo Massayoshi Shimo, Tatiani Brenelli Lima, Fernanda Aparecida Heleno Batista, Germanna Lima Righetto, José Geraldo de Carvalho Pereira, Daniela Campos Granato, Andrey Fabricio Ziem Nascimento, Fabio Cesar Gozzo, Paulo Sérgio Lopes de Oliveira, Ana Carolina Migliorini Figueira, Juliana Helena Costa Smetana, Adriana Franco Paes Leme, Mario Tyago Murakami, Celso Eduardo Benedetti
MAF1 is the main RNA polymerase (Pol) III repressor that controls cell growth in eukaryotes. The Citrus ortholog, CsMAF1, was shown to restrict cell growth in citrus canker disease but its role in plant development and disease is still unclear. We solved the crystal structure of the globular core of CsMAF1, which reveals additional structural elements compared with the previously available structure of hMAF1, and explored the dynamics of its flexible regions not present in the structure. CsMAF1 accumulated in the nucleolus upon leaf excision, and this translocation was inhibited by auxin and by mutation of the PKA phosphorylation site, S45, to aspartate...
July 24, 2017: Structure
https://www.readbyqxmd.com/read/28780518/birth-defects-after-use-of-antithyroid-drugs-in-early-pregnancy-a-swedish-nationwide-study
#19
Stine Linding Andersen, Stefan Lönn, Peter Vestergaard, Ove Törring
OBJECTIVE: Antithyroid drugs (ATDs) may have teratogenic effects, but more evidence is needed on the risk and types of birth defects after the use of Methimazole (MMI) and Propylthiouracil (PTU). This study aimed to evaluate the association between the use of ATDs in early pregnancy and birth defects. DESIGN: Swedish nationwide register-based cohort study. METHODS: The study included 684,340 children live-born in Sweden from 2006-2012. Exposure groups defined by maternal ATD use in early pregnancy were: MMI (n=162); PTU (n=218); MMI and PTU (n=66); ATD before or after, but not in pregnancy (n=1,551); and non-exposed (never ATD (n=682,343))...
August 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28780002/sex-specific-gene-expression-and-life-span-regulation
#20
REVIEW
John Tower
Aging-related diseases show a marked sex bias. For example, women live longer than men yet have more Alzheimer's disease and osteoporosis, whereas men have more cancer and Parkinson's disease. Understanding the role of sex will be important in designing interventions and in understanding basic aging mechanisms. Aging also shows sex differences in model organisms. Dietary restriction (DR), reduced insulin/IGF1-like signaling (IIS), and reduced TOR signaling each increase life span preferentially in females in both flies and mice...
August 2, 2017: Trends in Endocrinology and Metabolism: TEM
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