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https://www.readbyqxmd.com/read/29775740/eriocheir-sinensis-microrna-7-targets-crab-myd88-to-enhance-white-spot-syndrome-virus-replication
#1
Ying Huang, Wen Wang, Zhiqiang Xu, Jianlin Pan, Zhe Zhao, Qian Ren
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression at the posttranscriptional level. In this study, the function of microRNA-7 (miR-7) in host-virus interaction was investigated. Replication of White spot syndrome virus (WSSV) was enhanced with the overexpression of miR-7 and inhibited with the downregulation of miR-7 by using anti-miRNA oligonucleotide AMO-miR-7. The target gene of miR-7 was predicted using bioinformatics methods. Results showed that crab myeloid differentiation factor 88 (Myd88) could be targeted by miR-7...
May 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29738845/microrna-7-facilitates-the-degradation-of-alpha-synuclein-and-its-aggregates-by-promoting-autophagy
#2
Doo Chul Choi, Myungsik Yoo, Savan Kabaria, Eunsung Junn
Alpha-Synuclein (α-Syn) is an important protein in the pathogenesis of Parkinson disease (PD) as it accumulates as fibrillar inclusions in affected brain regions including dopaminergic neurons in the substantia nigra. Elevated levels of α-Syn seem to be crucial in mediating its toxicity. Thus, detailed information regarding the regulatory mechanism of α-Syn expression in several layers such as transcription, post-transcription and post-translation is needed in order to devise therapeutic interventions for PD...
May 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29728583/lncrna-oip5-as1-is-overexpressed-in-undifferentiated-oral-tumors-and-integrated-analysis-identifies-as-a-downstream-effector-of-stemness-associated-transcription-factors
#3
Ganesan Arunkumar, Shankar Anand, Partha Raksha, Shankar Dhamodharan, Harikrishnan Prasanna Srinivasa Rao, Shanmugam Subbiah, Avaniyapuram Kannan Murugan, Arasambattu Kannan Munirajan
Long non-coding RNAs (lncRNAs) play an important role in the regulation of key cellular processes in early development and cancer. LncRNA Oip5-as1 facilitates stem cell self-renewal in mouse by sponging mmu-miR-7 and modulating NANOG level, yet its role in cancer is less understood. We analyzed OIP5-AS1 expression in oral tumors and in TCGA datasets. We observed overexpression of OIP5-AS1 in oral tumors (P < 0.001) and in tumors of epithelial origin from TCGA. OIP5-AS1 expression was strongly associated with undifferentiated tumors (P = 0...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29723509/long-non-coding-rna-uca1-upregulation-promotes-the-migration-of-hypoxia-resistant-gastric-cancer-cells-through-the-mir-7-5p-egfr-axis
#4
Zichang Yang, Xiaonan Shi, Ce Li, Xiaoxun Wang, Kezuo Hou, Zhi Li, Xiaojie Zhang, Yibo Fan, Xiujuan Qu, Xiaofang Che, Yunpeng Liu
A variety of solid tumors are surrounded by a hypoxic microenvironment, which is known to be associated with high metastatic capability and resistance to various clinical therapies, contributing to a poor survival rate for cancer patients. Although the majority of previous studies on tumor-associated hypoxia have focused on acute hypoxia, chronic hypoxia more closely mimics the actual hypoxic microenvironment of a tumor. In this study, two novel hypoxia-resistant gastric cancer (HRGC) cell lines which could grow normally in 2% oxygen were established...
April 30, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29714132/mir-7-replacement-therapy-in-parkinson-s-disease
#5
Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeida
The present review examines whether the microRNA 7 (miR-7) holds potential for slowing Parkinson's disease (PD) progression. First, the accurate expression of miR-7 allows for the normal development, physiology, and neurogenesis in the central nervous system, also keeping alpha-synuclein (α-Syn) at the physiological level. Second, patients with PD and parkinsonian MPTP-induced animals exhibit a significant decrease of miR-7 in brain areas associated with dopaminergic neurodegeneration. Depletion of miR-7 in the substantia nigra of clinical samples was related to α-Syn accumulation, loss of dopaminergic cells, and reduction of dopamine in the striatum...
April 30, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29689389/deep-sequencing-of-small-rnas-in-blood-of-patients-with-brain-arteriovenous-malformations
#6
Yong Chen, Zhili Li, Yi Shi, Guangfu Huang, Longyi Chen, Haibin Tan, Zhenyu Wang, Cheng Yin, Junting Hu
BACKGROUND: The deregulation of circulating microRNAs (miRNAs) is always associated with development and progression of human diseases. We are aimed to assess whether brain arteriovenous malformations (BAVMs) patients present a distinct miRNA signature compared with healthy subjects. METHODS: Three unruptured BAVMs patients and three normal controls were recruited as case and normal groups. Peripheral blood was collected and miRNA signature was obtained by next-generation sequencing, followed by comparative, functional, and network analyses...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29686831/microarray-analysis-of-the-molecular-mechanism-involved-in-parkinson-s-disease
#7
Cheng Tan, Xiaoyang Liu, Jiajun Chen
Purpose: This study aimed to investigate the underlying molecular mechanisms of Parkinson's disease (PD) by bioinformatics. Methods: Using the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD patients and 19 matched controls, differentially expressed genes (DEGs) were identified after data preprocessing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#8
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29674246/a-microrna-expression-signature-of-the-postprandial-state-in-response-to-a-high-saturated-fat-challenge
#9
Sergio Lopez, Beatriz Bermudez, Sergio Montserrat-de la Paz, Rocio Abia, Francisco J G Muriana
The postprandial hypertriglyceridemia is an important and largely silent disturbance involved in the genesis of numerous pathological conditions. Exaggerated and prolonged states of postprandial hypertriglyceridemia are frequently related to the ingestion of meals enriched in saturated fatty acids (SFAs). MicroRNAs are noncoding RNAs that function as gene regulators and play significant roles in both health and disease. However, differential miRNA expression between fasting and postprandial states has never been elucidated...
March 18, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29673456/-intracerebroventricular-injection-of-mir-7-inhibits-secondary-brain-injury-induced-by-intracerebral-hemorrhage-via-egfr-stat3-pathway-in-rats
#10
Hong Qian, Ke Hu, Ming Xie, Heng Wu, Wenjun Li, Bin Wu, Rongyong Man, Meng Nie
Objective To observe the effects of microRNA-7 (miR-7) on intracerebral hemorrhage-induced brain injury in rats and explore the underlying mechanism. Methods Seventy-five SD rats were used to establish intracerebral hemorrhage model through injection of VII collagenase into the pallidum. These rats were then divided into control, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control groups, containing 15 animals in each group. On day 2 after modeling, rats were injected with 10 μL of physiological saline, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control via the lateral ventricle, respectively...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29663842/mir-7-inhibited-peripheral-nerve-injury-repair-by-affecting-neural-stem-cells-migration-and-proliferation-through-cdc42
#11
Nan Zhou, Shuang Hao, Zongqiang Huang, Weiwei Wang, Penghui Yan, Wei Zhou, Qihang Zhu, Xiaokang Liu
Objective Neural stem cells play an important role in the recovery and regeneration of peripheral nerve injury, and the microRNA-7 (miR-7) regulates differentiation of neural stem cells. This study aimed to explore the role of miR-7 in neural stem cells homing and proliferation and its influence on peripheral nerve injury repair. Methods The mice model of peripheral nerve injury was created by segmental sciatic nerve defect (sciatic nerve injury), and neural stem cells treatment was performed with a gelatin hydrogel conduit containing neural stem cells inserted into the sciatic nerve injury mice...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29663653/the-mir-7-and-bag-of-marbles-genes-regulate-hedgehog-pathway-signaling-in-blood-cell-progenitors-in-drosophila-larval-lymph-glands
#12
Tsuyoshi Tokusumi, Yumiko Tokusumi, Robert A Schulz
Hedgehog (Hh) pathway signaling is crucial for the maintenance of blood cell progenitors in the lymph gland hematopoietic organ present in Drosophila third instar larvae. Previous studies from our lab have likewise shown the importance of the mir-7 and bag of marbles (bam) genes in maintaining the progenitor state. Thus we sought to investigate a possible interaction between the Hh pathway and mir-7/bam in the prohemocyte population within this hematopoietic tissue. Gain of function mir-7 was able to rescue a blood cell progenitor depletion phenotype caused by Patched (Ptc) inhibition of Hh pathway signaling in these cells...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29655674/analysis-of-microrna-expression-in-the-thymus-of-myasthenia-gravis-patients-opens-new-research-avenues
#13
REVIEW
Mélanie A Cron, Solène Maillard, Fabien Delisle, Nolwenn Samson, Frédérique Truffault, Maria Foti, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Rozen Le Panse
In early-onset Myasthenia Gravis (MG) with anti-acetylcholine receptor antibodies, thymic abnormalities associated with ectopic germinal centers are frequent. miRNAs by acting as post-transcriptional regulators are involved in autoimmunity. To investigate the implication of miRNAs in thymic changes associated with early-onset MG, we performed a miRnome study and data were analyzed with different approaches. miRNAs of interest were further investigated by RT-PCR and transfection experiments for functional tests...
June 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29621542/glycolytic-inhibitor-2-deoxy-d-glucose-activates-migration-and-invasion-in-glioblastoma-cells-through-modulation-of-the-mir-7-5p-tff3-signaling-pathway
#14
Akanchha Shukla, Priyanka Gupta, Romila Singh, Durga Prasad Mishra
Glioblastomas (GBMs) are characterized by the metabolic shift towards aerobic glycolysis, rapid proliferation and acquisition of the migratory and invasive phenotype aiding tumor angiogenesis. The glycolytic inhibitor 2-Deoxy-d-glucose (2-DG) used for targeting glycolysis in GBMs is ineffective in inhibiting migration and invasion. In the present study we report that 2-DG treatment downregulates the tumor suppressive miR-7-5p in GBM cell lines in vitro. Overexpression of miR-7-5p significantly reduced migration and invasion in GBM cell lines...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29614984/up-regulation-of-cerna-tincr-by-sp1-contributes-to-tumorigenesis-in-breast-cancer
#15
Yun Liu, Yaying Du, Xiaopeng Hu, Lu Zhao, Wenfei Xia
BACKGROUND: Assembling evidences suggested that aberrant expression of tissue differentiation-inducing non-protein coding RNA (TINCR) intimately associated with variety of human cancer. However, the expression pattern and involvement of TINCR in breast cancer has not been fully investigated. Here we set out to analyze expression of TINCR in breast cancer and elucidate its mechanistic involvement in tumor incidence and progression. METHODS: The expression of TINCR was determined by q-PCR...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29603687/mir-7-mir-9-and-mir-375-contribute-to-effect-of-exendin-4-on-pancreatic-%C3%AE-cells-in-high-fat-diet-fed-mice
#16
Chang Guo, Yi-Qiong Sun, Qiang Li, Jin-Chao Zhang
PURPOSE: The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation of microRNAs and target genes in high-fat-diet-fed mice. METHODS: C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) and GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. or vehicle, for consecutive 13 weeks. Fasting blood glucose, postprandial blood glucose, ΔI30/ΔG30, HOMA-IR and HOMA-% β were measured in each group...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29589310/rt-qpcr-for-fecal-mature-microrna-quantification-and-validation
#17
Farid E Ahmed, Nancy C Ahmed, Mostafa M Gouda, Paul W Vos, Chris Bonnerup
By routinely and systematically being able to perform quantitative stem-loop reverse transcriptase (RT) followed by TaqMan® minor-groove binding (MGB) probe, real-time quantitative PCR analysis on exfoliated enriched colonocytes in stool, using human (Homo sapiens, hsa) micro(mi)RNAs to monitor changes of their expression at various stages of colorectal (CRC) progression, this method allows for the reliable and quantitative diagnostic screening of colon cancer (CC). Although the expression of some miRNA genes tested in tissue shows less variability in normal or cancerous patients than in stool, the noninvasive stool by itself is well suited for CC screening...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29564561/development-and-endoscopic-appearance-of-colorectal-tumors-are-characterized-by-the-expression-profiles-of-mirnas
#18
REVIEW
Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P)...
March 21, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29549306/circhipk3-promotes-colorectal-cancer-growth-and-metastasis-by-sponging-mir-7
#19
Kaixuan Zeng, Xiaoxiang Chen, Mu Xu, Xiangxiang Liu, Xiuxiu Hu, Tao Xu, Huiling Sun, Yuqin Pan, Bangshun He, Shukui Wang
Mounting evidences indicate that circular RNAs (circRNAs) have a vital role in human diseases, especially cancers. More recently, circHIPK3, a particularly abundant circRNA, was proposed to be involved in tumorigenesis. However, its role in colorectal cancer (CRC) has not been explored. In this study, we found circHIPK3 was significantly upregulated in CRC tissues and cell lines, at least in part, due to c-Myb overexpression and positively correlated with metastasis and advanced clinical stage. Moreover, Cox multivariate survival analysis showed that high-level expression of circHIPK3 was an independent prognostic factor of poor overall survival (OS) in CRC (hazard ratio [HR] = 2...
March 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29532994/cirs-7-targeting-mir-7-modulates-the-progression-of-non-small-cell-lung-cancer-in-a-manner-dependent-on-nf-%C3%AE%C2%BAb-signalling
#20
Chongyu Su, Yi Han, Hongtao Zhang, Yunsong Li, Ling Yi, Xiaojue Wang, Shijie Zhou, Daping Yu, Xiaoyun Song, Ning Xiao, Xiaoqing Cao, Zhidong Liu
The purpose of this study was to figure out the effect of ciRS-7/miR-7/NF-κB axis on the development of non-small cell lung cancer (NSCLC). In response, the expressions of ciRS-7, miR-7 and NF-κB subunit (ie RELA) within NSCLC tissues and cell lines were determined with real-time polymerase chain reaction (RT-PCR) and Western blot. Moreover, the NSCLC cells were transfected with pcDNA3-ciRS-7-ir, pcDNA3-ciRS-7, miR-NC and miR-7 mimic. Furthermore, the targeted relationships between ciRS-7 and miR-7, as well as between miR-7 and RELA, were confirmed by luciferase reporter assay...
March 13, 2018: Journal of Cellular and Molecular Medicine
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