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https://www.readbyqxmd.com/read/28496336/curcumin-exerts-its-antitumor-activity-through-regulation-of-mir-7-skp2-p21-in-nasopharyngeal-carcinoma-cells
#1
Shaoyan Feng, Yu Wang, Rongkai Zhang, Guangwei Yang, Zibin Liang, Zhiwei Wang, Gehua Zhang
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28483648/oleic-acid-induces-mir-7-processing-through-remodelling-of-pri-mir-7-protein-complex
#2
Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski
MicroRNAs (miRs) play a vital role in governing cell function, with their levels tightly controlled at transcriptional and post-transcriptional levels. Different sets of RNA-binding proteins (RNA-BPs) interact with primary (pri-) miRs and precursor (pre-) miR transcripts, controlling their biogenesis post-transcriptionally. The Hu antigen R (HuR)-mediated binding of Musashi homolog2 (MSI2) to the Conserved Terminal Loop (CTL) of pri-miR-7 regulates the levels of brain-enriched miR-7 formation in a tissue specific manner...
May 5, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28459998/identification-of-mirna-7-by-genome-wide-analysis-as-a-critical-sensitizer-for-trail-induced-apoptosis-in-glioblastoma-cells
#3
Xiao Zhang, Xiang Zhang, Shijie Hu, Minhua Zheng, Jie Zhang, Jianhui Zhao, Xiaofang Zhang, Bo Yan, Lintao Jia, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang
Glioblastoma (GBM) is still one of the most lethal forms of brain tumor despite of the improvements in treatments. TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. To define the novel pathways that regulate susceptibility to TRAIL in GBM cells, we performed a genome-wide expression profiling of microRNAs in GBM cell lines with the distinct sensitivity to TRAIL-induced apoptosis...
April 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28450156/microrna-7-impairs-autophagy-derived-pools-of-glucose-to-suppress-pancreatic-cancer-progression
#4
Dian-Na Gu, Ming-Jie Jiang, Zhu Mei, Juan-Juan Dai, Chen-Yun Dai, Chi Fang, Qian Huang, Ling Tian
Pancreatic cancer commonly addicts to aerobic glycolysis, and abnormally activates autophagy to adapt the stringent metabolic microenvironment. microRNA-7 (miR-7) was supposed to modulate various gastrointestinal cancer progression. We wonder whether miR-7 could destroy the reprogrammed metabolic homeostasis in pancreatic cancer via modulating the level of autophagy, and further affect tumor proliferation and survival. Herein, we first reported that pancreatic cancer could take advantage of autophagy as a survival strategy to provide essential glucose required for glycolysis metabolism...
April 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28435295/silencing-cdr1as-inhibits-colorectal-cancer-progression-through-regulating-microrna-7
#5
Wentao Tang, Meiling Ji, Guodong He, Liangliang Yang, Zhengchuan Niu, Mi Jian, Ye Wei, Li Ren, Jianmin Xu
An increasing number of studies have demonstrated that circular RNAs (circRNAs) can regulate gene expression through interacting with microRNAs. In this study, we analyzed the expression of antisense to CDR1as in colorectal cancer (CRC). CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28393181/microrna-based-molecular-classification-of-papillary-thyroid-carcinoma
#6
Francesca Rosignolo, Lorenzo Memeo, Fabio Monzani, Cristina Colarossi, Valeria Pecce, Antonella Verrienti, Cosimo Durante, Giorgio Grani, Livia Lamartina, Stefano Forte, Daniela Martinetti, Dario Giuffrida, Diego Russo, Fulvio Basolo, Sebastiano Filetti, Marialuisa Sponziello
MicroRNA (miRNA) expression is dysregulated in many human malignancies, and a growing number of studies are focused on their potential use as tumor biomarkers. To identify a miRNA signature for papillary thyroid carcinomas (PTC), we investigated miRNA expression profiles in two independent cohorts of PTCs, which included major histological subtypes [classical-type (PTC‑CT), follicular-variant (PTC‑FV), and tall-cell variant (PTC‑TCV)] and cases with low or intermediate risk of recurrence. Using TaqMan® Array Human MicroRNA A+B Cards v3...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28388561/cell-free-microrna-expression-signatures-in-urine-serve-as-novel-noninvasive-biomarkers-for-diagnosis-and-recurrence-prediction-of-bladder-cancer
#7
Lutao Du, Xiumei Jiang, Weili Duan, Rui Wang, Lishui Wang, Guixi Zheng, Keqiang Yan, Lili Wang, Juan Li, Xin Zhang, Hongwei Pan, Yongmei Yang, Chuanxin Wang
Urinary microRNAs (miRNAs) are potential biomarkers for the noninvasive diagnosis of bladder cancer (BC). In this study, we aimed to develop a urinary miRNAs panel for diagnosing and predicting recurrence of BC. Genome-wide miRNAs analysis by deep sequencing followed by two phases of quantitative real-time PCR assays were performed on urine supernatant of 276 BC patients and 276 controls. We identified a seven-miRNA panel (miR-7-5p, miR-22-3p, miR-29a-3p, miR-126-5p, miR-200a-3p, miR-375, and miR-423-5p) that provided high diagnostic accuracy of BC with an AUC of 0...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28344345/gastric-bypass-surgery-with-exercise-alters-plasma-micrornas-that-predict-improvements-in-cardiometabolic-risk
#8
Y O Nunez Lopez, P M Coen, B H Goodpaster, A A Seyhan
BACKGROUND/OBJECTIVES: Roux-en-Y gastric bypass (RYGB) surgery improves insulin sensitivity (SI) and β-cell function in obese non-diabetic subjects. Exercise also improves SI and may be an effective adjunct therapy to RYGB surgery. However, the mechanisms by which exercise or weight loss improve peripheral SI after RYGB surgery are unclear. We hypothesized that microRNAs (miRNAs) mediate at least some of the regulatory processes driving such mechanisms. Consequently, this work aimed at profiling plasma miRNAs in participants of the Physical Activity Following Surgery Induced Weight Loss study (clinicaltrials...
April 25, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28325285/targeted-expression-of-mir-7-operated-by-ttf-1-promoter-inhibited-the-growth-of-human-lung-cancer-through-the-ndufa4-pathway
#9
Liangyu Lei, Chao Chen, Juanjuan Zhao, HaiRong Wang, Mengmeng Guo, Ya Zhou, Junming Luo, Jidong Zhang, Lin Xu
Targeted expression of gene technique is an important therapeutic strategy for lung cancer. MicroRNA-7 has been well documented as a promising tumor suppressor but never been test in specific gene-promoter-targeted expression in cancer gene therapy. Here, we first evaluated the efficacy of miR-7 expression operated by the promoter of TTF-1, a lineage-specific oncogene in lung cancer, in vitro using an eukaryotic vector of TTF-1-promoter-operated expression of miR-7 (termed as p-T-miR-7). Interestingly, using a nude mice model, the growth and metastasis of human lung cancer cells in vivo were significantly reduced in remote hypodermic injection of the p-T-miR-7 group, accompanied by increased expression of miR-7 and reduced transduction of the Akt and Erk pathway in situ...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28322989/role-of-micrornas-in-endocrine-cancer-metastasis
#10
Cilene Rebouças Lima, Cibele Crastequini Gomes, Marinilce Fagundes Santos
The deregulation of transcription and processing of microRNAs (miRNAs), as well as their function, has been involved in the pathogenesis of several human diseases, including cancer. Despite advances in therapeutic approaches, cancer still represents one of the major health problems worldwide. Cancer metastasis is an aggravating factor in tumor progression, related to increased treatment complexity and a worse prognosis. After more than one decade of extensive studies of miRNAs, the fundamental role of these molecules in cancer progression and metastasis is beginning to be elucidated...
March 18, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28314263/significance-and-function-of-microrna-7-in-oesophageal-squamous-cell-carcinoma
#11
Keigo Hara, Tatsuya Miyazaki, Takehiko Yokobori, Tomonori Yoshida, Yuji Kumakura, Hiroaki Honjyo, Makoto Sakai, Makoto Sohda, Minoru Fukuchi, Hiroyuki Kuwano
BACKGROUND/AIM: We detected microRNA-7 (miR-7) as being specific for oesophageal squamous cell carcinoma (ESCC) by using database analysis. However, the significance of miR-7 in clinical ESCC remains unexplored. This study aimed to clarify the clinicopathological significance of miR-7 in ESCC, and investigate miR-7 function. MATERIALS AND METHODS: Quantitative TaqMan reverse transcription polymerase chain reaction was used to evaluate miR-7 expression in 85 ESCC samples to determine the clinicopathological significance of miR-7 expression...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28296235/the-circular-rna-cirs-7-promotes-app-and-bace1-degradation-in-an-nf-%C3%AE%C2%BAb-dependent-manner
#12
Zhemin Shi, Ting Chen, Qingbin Yao, Lina Zheng, Zhen Zhang, Jingzhao Wang, Zhimei Hu, Hongmei Cui, Yawei Han, Xiaohui Han, Kun Zhang, Wei Hong
The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease (AD), and enhanced cleavage of β-amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) has a major causative role in AD. Despite their prominence in AD pathogenesis, the regulation of BACE1 and APP is incompletely understood. In this study, we report that the circular RNA circular RNA sponge for miR-7 (ciRS-7) has an important role in regulating BACE1 and APP protein levels. Previous studies have shown that ciRS-7, which is highly expressed in the human brain, is down-regulated in the brain of people with AD but the relevance of this finding was not clear...
April 2017: FEBS Journal
https://www.readbyqxmd.com/read/28259961/microrna-7-functions-as-a-tumor-suppressor-gene-by-regulating-ilf2-in-pancreatic-carcinoma
#13
Yiliang Bi, Wei Shen, Min Min, Yan Liu
Interleukin enhancer binding factor 2 (ILF2) has been found to be markedly upregulated in pancreatic carcinoma and is involved in the pathogenesis of pancreatic carcinoma. Thus, ILF2 may be a potential target for therapy. Yet, the regulatory mechanisms of ILF2 in pancreatic carcinoma remain largely elusive. In the present study, we demonstrated that ILF2 functioned as an oncogene and regulated epithelial-mesenchymal transition (EMT)-associated genes in pancreatic carcinoma PANC-1 cells. MicroRNA-7 (miR-7) suppressed ILF2 mRNA expression and the protein level in PANC-1 cells...
April 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28253710/detection-and-characterization-of-cirs-7-a-potential-promoter-of-the-development-of-cancer
#14
X B Zheng, M Zhang, M Q X
Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in terms of development and application as a new kind of clinical marker. In addition, according to recent studies, circular RNA-7 (ciRS-7) acts as a sponge of miR-7 and thus inhibits its activity...
March 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28239300/mir-7-inhibits-progression-of-hepatocarcinoma-by-targeting-klf-4-and-promises-a-novel-diagnostic-biomarker
#15
Weizhong Wu, Sanguang Liu, Yunfei Liang, Zegao Zhou, Xueqing Liu
BACKGROUND: MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. However, the function of miR-7 in HCC remains to be demonstrated. METHODS: 50 paired HCC tissues and matched peritumor tissues from patients were collected...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28229971/breviscapine-suppresses-the-growth-of-non-small-cell-lung-cancer-by-enhancing-microrna-7-expression
#16
Jian Zeng, Shunv Cai
Breviscapine (BVP) has previously been shown to inhibit the proliferation of hepatocellular carcinoma cells. However, little is known about the effects of BVP on non-small cell lung cancer (NSCLC) growth. Here, we aimed to study the effects of BVP on human NSCLC growth. We employed A549, NCL-H460 and A549 cells transfected with microRNA-7 (miR-7) mimic and inhibitor to investigate the effect of BVP on cell proliferation, apoptosis and apoptosis-associated molecules. The results showed that BVP significantly reduced the growth of A549 and NCLH460 cells in a concentration-dependent and time-dependent manner, accompanied by a significant elevation of apoptosis...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28218624/loss-of-microrna-7a2-induces-hypogonadotropic-hypogonadism-and-infertility
#17
Kashan Ahmed, Mary P LaPierre, Emanuel Gasser, Rémy Denzler, Yinjie Yang, Thomas Rülicke, Jukka Kero, Mathieu Latreille, Markus Stoffel
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses to physiologic and pathophysiologic stresses. Here, we have reported that a single member of the evolutionarily conserved miR-7 family, miR-7a2, is essential for normal pituitary development and hypothalamic-pituitary-gonadal (HPG) function in adulthood. Genetic deletion of mir-7a2 causes infertility, with low levels of gonadotropic and sex steroid hormones, small testes or ovaries, impaired spermatogenesis, and lack of ovulation in male and female mice, respectively...
March 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28216373/tweak-stimulated-macrophages-inhibit-metastasis-of-epithelial-ovarian-cancer-via-exosomal-shuttling-of-microrna
#18
Yuan Hu, Dong Li, Anyue Wu, Xingdi Qiu, Wen Di, Lei Huang, Lihua Qiu
Exosomal-miRNAs are emerging as mediators of crosstalk between tumor cells and macrophages. In this study, we observed that exosomes derived from TWEAK-stimulated macrophages (TMs) could be internalized by epithelial ovarian cancer (EOC) cells and inhibit cell metastasis. Through a miRNA microarray analysis, we identified 19 miRNAs that are differentially expressed in exosomes derived from macrophages treated with or without TWEAK. The study validated that TWEAK not only increased the levels of microRNA-7 (miR-7) in macrophages and its secreted exosomes but also resulted in an elevated level of miR-7 in recipient EOC cells, which eventually reduced the activity of the EGFR/AKT/ERK1/2 pathway...
February 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28181130/micrornas-mir-7-and-mir-340-predict-response-to-neoadjuvant-chemotherapy-in-breast-cancer
#19
Mithu Raychaudhuri, Holger Bronger, Theresa Buchner, Marion Kiechle, Wilko Weichert, Stefanie Avril
PURPOSE: miRNAs have been linked to chemosensitivity of breast cancer cells in vitro. In patients, however, there is no clinically validated method for predicting chemotherapy response. The aim of this study was to assess whether (I) a specific pattern of miRNA expression in pretherapeutic biopsies can predict response to neoadjuvant chemotherapy, and (II) differential miRNA expression in residual tumor after completion of chemotherapy allows further prognostic stratification of non-responding patients...
April 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28174233/circular-rna-cirs-7-a-promising-prognostic-biomarker-and-a-potential-therapeutic-target-in-colorectal-cancer
#20
Wenhao Weng, Qing Wei, Shusuke Toden, Kazuhiro Yoshida, Takeshi Nagasaka, Toshiyoshi Fujiwara, Sanjun Cai, Huanlong Qin, Yanlei Ma, Ajay Goel
PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. Since miR-7 regulates the expression of several important drivers of CRC, we analyzed the clinical significance of ciRS-7 in CRC patients. EXPERIMENTAL DESIGN: Initially, we evaluated the expression levels of ciRS-7 in a training cohort comprising of 153 primary CRC tissues and 44 matched normal mucosae...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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