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https://www.readbyqxmd.com/read/28710399/downregulation-of-blood-serum-microrna-29-family-in-patients-with-parkinson-s-disease
#1
Xiaochen Bai, Yilin Tang, Mei Yu, Lei Wu, Fengtao Liu, Jianliang Ni, Zishan Wang, Jinghui Wang, Jian Fei, Wei Wang, Fang Huang, Jian Wang
There is currently no reliable and easily applicable diagnostic marker for Parkinson's disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in blood serum from patients with PD with healthy controls and to clarify whether the expression of miR-29s is correlated with disease severity, duration or L-dopa therapy and whether expression depends on the gender and age of patients. The levels of blood serum miR-29s in 80 patients with PD and 80 unaffected controls were assessed by reverse transcription-quantitative real-time PCR...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704127/retinal-mirnas-variations-in-a-large-cohort-of-inherited-retinal-disease
#2
Xiu-Feng Huang, Zhi-Qin Huang, Xiao-Long Fang, Zhen-Ji Chen, Wan Cheng, Zi-Bing Jin
BACKGROUND: Although great efforts have been paid on identification of genetic predisposition in the inherited retinal disease (IRD), genetic causes of a large proportion of patients remain a mystery. This dilemma makes us attempt to speculate that genetic components other than coding genes might be an additional pool predisposing IRD. In this study, we aim to perform a mutational screening in a large cohort of IRD patients with a particular focus on retina-specific or abundant microRNAs (miRs)...
July 13, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28693382/mir-7-increases-cisplatin-sensitivity-of-gastric-cancer-cells-through-suppressing-mtor
#3
Ning Xu, Yan-Jun Lian, Xiang Dai, Yuan-Jie Wang
MicroRNAs have been reported to play an important role in diverse biological processes and cancer progression. MicroRNA-7 has been observed to be downregulated in human gastric cancer tissues, but the function of microRNA-7 in gastric cancer has not been well investigated. In this study, we demonstrate that the expression of microRNA-7 was significantly downregulated in 30 pairs of human gastric cancer tissues compared to adjacent normal tissues. Enforced expression of microRNA-7 inhibited cell proliferation and migration abilities of gastric cancer cells, BGC823 and SGC7901...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28690499/reduced-circulating-levels-of-mir-433-and-mir-133b-are-potential-biomarkers-for-parkinson-s-disease
#4
Xiong Zhang, Rui Yang, Bei-Lei Hu, Pengcheng Lu, Li-Li Zhou, Zhi-Yong He, Hong-Mei Wu, Jian-Hong Zhu
Aberrant expression of microRNA (miRNA) in tissues may lead to altered level in circulation. Considerable evidence has suggested that miRNA deregulation is involved in the pathogenesis of Parkinson's disease (PD). In this study, we screened a set of PD-associated miRNAs and aimed to identify differentially expressed miRNAs in plasma of PD patients and to evaluate their potentiality to serve as PD biomarkers. A total of 95 subjects consisting of 46 sporadic PD cases and 49 controls were recruited. Plasma levels of six miRNAs including miR-433, miR-133b, miR-34b, miR-34c, miR-153, and miR-7 were evaluated using reverse transcribed quantitative PCR, among which we found that miR-34c and miR-7 were below detection limit under our condition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28646700/increased-serum-mir-7-is-a-promising-biomarker-for-type-2-diabetes-mellitus-and-its-microvascular-complications
#5
Shujun Wan, Jun Wang, Jing Wang, Jia Wu, Jiaxi Song, Chen-Yu Zhang, Chunni Zhang, Cheng Wang, Jun-Jun Wang
AIMS: To investigate the alteration pattern and physiologic state of islet-specific miR-7 in the serum of patients with type 2 diabetes mellitus (T2DM) and T2DM-associated microvascular complications (T2DMC) and to evaluate its clinical significance. METHODS: The levels of serum miR-7 were firstly examined and compared in 76 T2DM patients, 76 T2DMC patients and 74 age-gender matched controls using RT-qPCR. Subsequently, the physiologic state of serum miR-7 was characterized by determining its concentrations in isolated exosomes and corresponding exosome-free samples from the same three cohorts' samples...
June 11, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28627600/microrna%C3%A2-7%C3%A2-5p-regulates-the-expression-of-tff3-in-inflammatory-bowel-disease
#6
Jing Guo, Mei Sun, Xu Teng, Lingfen Xu
Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry was applied to evaluate the relative expression of TFF3, and reverse transcription‑quantitative polymerase chain reaction was performed to determine the expression of miR‑7‑5p in lesional tissue obtained from patients with IBD and healthy control tissues...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28618418/prognostic-significance-of-microrna-7-and-its-roles-in-the-regulation-of-cisplatin-resistance-in-lung-adenocarcinoma
#7
Mao-Wei Cheng, Ze-Tian Shen, Gu-Yu Hu, Li-Guo Luo
BACKGROUND: Previously, microRNA (miR)-7 has been reported to function as a tumor suppressor in human cancers, but the correlations of miR-7 expression with prognosis and cisplatin (CDDP) resistance in lung adenocarcinoma (LA) are unclear. Here, our aim is to determine the prognostic significance of miR-7 and its roles in the regulation of CDDP resistance in LA. METHODS: Quantitative real-time PCR (qRT-PCR) assay was performed to determine miR-7 expression in 108 paired of LA tissues and analyze its correlations with clinicopathological factors of patients...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28617957/microrna-a-novel-target-of-curcumin-in-cancer-therapy
#8
REVIEW
Hamed Mirzaei, Aria Masoudifar, Amirhossein Sahebkar, Naser Zare, Javid Sadri Nahand, Bahman Rashidi, Emadodin Mehrabian, Mohsen Mohammadi, Hamid Reza Mirzaei, Mahmoud Reza Jaafari
Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa L. It has been shown that curcumin has a variety of pharmacological effects such as antioxidant, anti-cancer, anti-inflammatory, and anti-microbial activities. Anti-cancer effects of curcumin are due to targeting of a wide range of cellular and molecular pathways involved in cancer pathogenesis including NF-kB, MAPK, PTEN, P53, and microRNAs (miRNA) network. Multiple lines of evidence have indicated that curcumin exerts its therapeutic effects via regulating miRNA expression (e...
June 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28608528/overexpression-of-circular-rna-cirs-7-abrogates-the-tumor-suppressive-effect-of-mir-7-on-gastric-cancer-via-pten-pi3k-akt-signaling-pathway
#9
Haiyan Pan, Tao Li, Yugang Jiang, Congcong Pan, Yuanlin Ding, Zhigang Huang, Haibing Yu, Danli Kong
OBJECTIVE: Gastric cancer (GC) has one of the highest mortality rates of malignancies globally. Currently, ciRS-7, a novel circular RNA, has emerged as a potential sponge for miR-7. However, few studies on ciRS-7 in GC have been performed. In this study, we investigated the clinical significance and function of ciRS-7 in GC. MATERIALS AND METHODS: Firstly, the expression levels of ciRS-7 in 102 primary GC tissues and the matched para-carcinoma tissues were evaluated and the clinical relevance was confirmed in an independent validation cohort (n = 154)...
June 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28587396/identification-of-the-mirna-target-gene-regulatory-network-in-intracranial-aneurysm-based-on-microarray-expression-data
#10
Kezhen Wang, Xinmin Wang, Hongzhu Lv, Chengzhi Cui, Jiyong Leng, Kai Xu, Guosong Yu, Jianwei Chen, Peiyu Cong
Intracranial aneurysm (IA) remains one of the most devastating neurological conditions. However, the pathophysiology of IA formation and rupture still remains unclear. The purpose of the present study was to identify the crucial microRNA (miRNA/miR) and genes involved in IAs and elucidate the mechanisms underlying the development of IAs. In the present study, novel miRNA regulation activities in IAs were investigated through the integration of public gene expression data of miRNA and mRNA using the Gene Expression Omnibus database, combined with bioinformatics prediction...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28579393/long-noncoding-rna-moderates-microrna-activity-to-maintain-self-renewal-in-embryonic-stem-cells
#11
Keriayn N Smith, Joshua Starmer, Sarah C Miller, Praveen Sethupathy, Terry Magnuson
Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the pluripotent state. In ESCs, Cyrano is a stably expressed long intergenic noncoding RNA with no previously assigned role. We demonstrate that Cyrano contributes to ESC maintenance, as its depletion results in the loss of hallmarks of self-renewal. Delineation of Cyrano's network through transcriptomics revealed widespread effects on signaling pathways and gene expression networks that contribute to ESC maintenance...
July 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28576406/puerarin-promotes-abca1-mediated-cholesterol-efflux-and-decreases-cellular-lipid-accumulation-in-thp-1-macrophages
#12
Cong-Hui Li, Duo Gong, Ling-Yan Chen, Min Zhang, Xiao-Dan Xia, Hai-Peng Cheng, Chong Huang, Zhen-Wang Zhao, Xi-Long Zheng, Xiao-Er Tang, Chao-Ke Tang
It was reported that puerarin decreases the total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and increases high-density lipoprotein cholesterol (HDL-C) level, but the underlying mechanism is unclear. This study was designed to determine whether puerarin decreased lipid accumulation via up-regulation of ABCA1-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. Our results showed that puerarin significantly promoted the expression of ATP-binding cassette transporter A1 (ABCA1) mRNA and protein via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor gamma (PPARγ)-liver X receptor-alpha (LXR-α) pathway and decreased cellular lipid accumulation in human THP-1 macrophage-derived foam cells...
May 30, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28571043/microrna-7-suppresses-the-homing-and-migration-potential-of-human-endothelial-cells-to-highly-metastatic-human-breast-cancer-cells
#13
Yu-Xin Cui, Robyn Bradbury, Valentina Flamini, Bo Wu, Nicola Jordan, Wen G Jiang
BACKGROUND: MicroRNA-7 (miR-7) has been observed as a potent tumour suppressor in multiple cancer types including breast cancer. The aim of this study was to investigate the response sensitivities of metastatic breast cancer cells to miR-7 and the roles of miR-7 in the interaction of endothelial cells and metastatic cancer cells. METHODS: Expression profile of miRNAs in a breast cancer specimen cohort and breast cancer cells were determined using real-time quantitative miRNA assays...
June 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28546132/identification-of-direct-target-genes-of-mir-7-mir-9-mir-96-and-mir-182-in-the-human-breast-cancer-cell-lines-mcf-7-and-mda-mb-231
#14
Hamidreza Moazzeni, Ali Najafi, Marzieh Khani
Some microRNAs have carcinogenic or tumor suppressive effects in breast cancer, which is the most common cancer in women worldwide. MiR-7 and miR-9 are tumor suppressor microRNAs, which induce apoptosis and inhibit proliferation in breast cancer cells. Moreover, miR-96 and miR-182 are onco-microRNAs that increase proliferation, migration, and tumorigenesis in breast cancer cells. This study aimed to identify the direct target genes of these four microRNAs in the human breast cancer cell lines MCF-7 and MDA-MB-231...
May 22, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28496336/curcumin-exerts-its-antitumor-activity-through-regulation-of-mir-7-skp2-p21-in-nasopharyngeal-carcinoma-cells
#15
Shaoyan Feng, Yu Wang, Rongkai Zhang, Guangwei Yang, Zibin Liang, Zhiwei Wang, Gehua Zhang
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28483648/oleic-acid-induces-mir-7-processing-through-remodeling-of-pri-mir-7-protein-complex
#16
Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski
MicroRNAs (miRs) play a vital role in governing cell function, with their levels tightly controlled at transcriptional and post-transcriptional levels. Different sets of RNA-binding proteins interact with primary miRs (pri-miRs) and precursor-miR transcripts (pre-miRs), controlling their biogenesis post-transcriptionally. The Hu antigen R (HuR)-mediated binding of Musashi homolog2 (MSI2) to the conserved terminal loop of pri-miR-7 regulates the levels of brain-enriched miR-7 formation in a tissue-specific manner...
June 2, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28459998/identification-of-mirna-7-by-genome-wide-analysis-as-a-critical-sensitizer-for-trail-induced-apoptosis-in-glioblastoma-cells
#17
Xiao Zhang, Xiang Zhang, Shijie Hu, Minhua Zheng, Jie Zhang, Jianhui Zhao, Xiaofang Zhang, Bo Yan, Lintao Jia, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang
Glioblastoma (GBM) is still one of the most lethal forms of brain tumor despite of the improvements in treatments. TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. To define the novel pathways that regulate susceptibility to TRAIL in GBM cells, we performed a genome-wide expression profiling of microRNAs in GBM cell lines with the distinct sensitivity to TRAIL-induced apoptosis...
June 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28450156/microrna-7-impairs-autophagy-derived-pools-of-glucose-to-suppress-pancreatic-cancer-progression
#18
Dian-Na Gu, Ming-Jie Jiang, Zhu Mei, Juan-Juan Dai, Chen-Yun Dai, Chi Fang, Qian Huang, Ling Tian
Pancreatic cancer commonly addicts to aerobic glycolysis, and abnormally activates autophagy to adapt the stringent metabolic microenvironment. microRNA-7 (miR-7) was supposed to modulate various gastrointestinal cancer progression. We wonder whether miR-7 could destroy the reprogrammed metabolic homeostasis in pancreatic cancer via modulating the level of autophagy, and further affect tumor proliferation and survival. Herein, we first reported that pancreatic cancer could take advantage of autophagy as a survival strategy to provide essential glucose required for glycolysis metabolism...
April 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28435295/silencing-cdr1as-inhibits-colorectal-cancer-progression-through-regulating-microrna-7
#19
Wentao Tang, Meiling Ji, Guodong He, Liangliang Yang, Zhengchuan Niu, Mi Jian, Ye Wei, Li Ren, Jianmin Xu
An increasing number of studies have demonstrated that circular RNAs (circRNAs) can regulate gene expression through interacting with microRNAs. In this study, we analyzed the expression of antisense to CDR1as in colorectal cancer (CRC). CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28393181/microrna-based-molecular-classification-of-papillary-thyroid-carcinoma
#20
Francesca Rosignolo, Lorenzo Memeo, Fabio Monzani, Cristina Colarossi, Valeria Pecce, Antonella Verrienti, Cosimo Durante, Giorgio Grani, Livia Lamartina, Stefano Forte, Daniela Martinetti, Dario Giuffrida, Diego Russo, Fulvio Basolo, Sebastiano Filetti, Marialuisa Sponziello
MicroRNA (miRNA) expression is dysregulated in many human malignancies, and a growing number of studies are focused on their potential use as tumor biomarkers. To identify a miRNA signature for papillary thyroid carcinomas (PTC), we investigated miRNA expression profiles in two independent cohorts of PTCs, which included major histological subtypes [classical-type (PTC‑CT), follicular-variant (PTC‑FV), and tall-cell variant (PTC‑TCV)] and cases with low or intermediate risk of recurrence. Using TaqMan® Array Human MicroRNA A+B Cards v3...
May 2017: International Journal of Oncology
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