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https://www.readbyqxmd.com/read/27901488/cancer-associated-fibroblasts-promote-cancer-cell-growth-through-a-mir-7-rassf2-par-4-axis-in-the-tumor-microenvironment
#1
Zongze Shen, Xing Qin, Ming Yan, Rongrong Li, Gang Chen, Jianjun Zhang, Wantao Chen
Cancer-associated fibroblasts (CAFs), a major component of cancer stroma, play an important role in cancer progression but little is known about how CAFs affect tumorigenesis and development. MicroRNAs (miRNAs) are small non-coding RNAs that can negatively regulate target mRNA expression at post-transcriptional levels. In head and neck cancer (HNC), our analysis of miRNA arrays showed that miR-7, miR-196 and miR-335 were significantly up-regulated in CAFs when compared with their paired normal fibroblasts (NFs)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27825947/characterization-of-micrornas-by-deep-sequencing-in-red-claw-crayfish-cherax-quadricarinatus-haematopoietic-tissue-cells-after-white-spot-syndrome-virus-infection
#2
Meng-Ru Zhao, Chuang Meng, Xiao-Lu Xie, Cheng-Hua Li, Hai-Peng Liu
White spot syndrome virus (WSSV) is one of the most prevalent and widespread viruses in both shrimp and crayfish aquaculture. MicroRNAs (miRNAs) are crucial post-transcriptional regulators and play critical roles in cell differentiation and proliferation, apoptosis, signal transduction and immunity. In this study, miRNA expression profiles were identified via deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue (Hpt) cell cultures infected with WSSV at both early (i.e., 1 hpi) and late (i...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27796758/circular-rnas-the-emerging-class-of-non-coding-rnas-and-their-potential-role-in-human-neurodegenerative-diseases
#3
REVIEW
Lalit Kumar, Shamsuzzama, Rizwanul Haque, Tanvi Baghel, Aamir Nazir
The exciting world of research with RNAs has to its credit some breakthrough findings that led to newer insights on multiple problems including that of human diseases. After the advent of siRNA, microRNA, and lncRNA, exciting novel molecules called circular RNAs (circRNAs) have been recently described. circRNAs are a class of non-coding RNAs, which are produced by scrambling of exons at the time of splicing. They are primarily produced in the brain region and are naturally present inside the cell. The best known ones so far include a particular type of circRNA namely "circular RNA sponge for miR-7" (ciRS-7 and CDR1as) which is the inhibitor of miR-7 microRNA-known to regulate various diseases like, cancer, neurodegenerative diseases, diabetes, and atherosclerosis...
October 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27793030/primary-tumor-microrna-signature-predicts-recurrence-and-survival-in-patients-with-locally-advanced-esophageal-adenocarcinoma
#4
Daisuke Matsui, Ali H Zaidi, Samantha A Martin, Ashten N Omstead, Juliann E Kosovec, Luai Huleihel, Lindsey T Saldin, Christina DiCarlo, Jan F Silverman, Toshitaka Hoppo, Gene G Finley, Stephen F Badylak, Ronan J Kelly, Blair A Jobe
Esophageal adenocarcinoma (EAC) is an aggressive cancer necessitating the development of improved risk stratification tools for personalized care. Previously, microRNAs have been shown to correlate with the progression and prognosis of various cancer types; however, the value in EAC remains largely unexplored. We performed global microRNA profiling on 32 formalin-fixed, paraffin-embedded EAC specimens to identify microRNAs associated with progression. Literature search and pathway analysis further refined output to five significantly deregulated candidate biomarkers...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27774091/microrna-7-deficiency-ameliorates-the-pathologies-of-acute-lung-injury-through-elevating-klf4
#5
Juanjuan Zhao, Chao Chen, Mengmeng Guo, Yijin Tao, PanPan Cui, Ya Zhou, Nalin Qin, Jing Zheng, Jidong Zhang, Lin Xu
Recent evidence showed that microRNA-7 (miR-7) played an important role in the pathologies of lung-related diseases. However, the potential role of miR-7 in acute lung injury (ALI) still remains poorly understood. Here, we assessed the effect of miR-7 deficiency on the pathology of ALI. We, first, found that the expression of miR-7 was upregulated in lung tissue in murine LPS-induced ALI model. Notably, we generated miR-7 knock down mice by using miRNA-Sponge technique and found that miR-7 deficiency could ameliorate the pathologies of lung as evidenced by accelerated body weight recovery, reduced level of bronchoalveolar lavage (BAL) proinflammatory cytokines and decreased number of BAL cells in ALI mice...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27764812/microrna-7-inhibits-cell-proliferation-migration-and-invasion-in-human-non-small-cell-lung-cancer-cells-by-targeting-fak-through-erk-mapk-signaling-pathway
#6
Qi Cao, Zheng-Dao Mao, Yu-Jia Shi, Yi Chen, Yun Sun, Qian Zhang, Lei Song, Li-Ping Peng
OBJECTIVE: To investigate the effects of microRNA-7 (miR-7) on the proliferation, migration and invasion of non-small cell lung cancer NSCLC) cells by targeting FAK through ERK/MAPK signaling pathway. METHODS: NSCLC tissues and adjacent normal tissues were obtained from 160 NSCLC patients after operation. NSCLC cell lines (A549, H1299 and H1355) and a normal human fetal lung fibroblast cell line (MRC-5) were obtained. NSCLC cells were assigned into miR-7 inhibitors, miR-7 mimics, blank, miR-7 mimics control, miR-7 inhibitors control, FAK siRNA and miR-7 inhibitors + FAK siRNA groups...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27749601/microrna-210-microrna-331-and-microrna-7-are-differentially-regulated-in-treated-hiv-1-infected-individuals-and-are-associated-with-markers-of-systemic-inflammation
#7
Vibe Ballegaard, Ulrik Ralfkiaer, Karin K Pedersen, Malene Hove, Simon Koplev, Peter Brændstrup, Lars P Ryder, Hans O Madsen, Jan Gerstoft, Kirsten Grønbæk, Susanne D Nielsen
OBJECTIVE: Inflammation may contribute to increased risk of cardiovascular disease (CVD) in HIV-1 infection. MicroRNAs (miRNAs) are involved in the regulation of inflammation. In treated HIV-1-infected individuals, we aimed to identify differentially expressed miRNAs with known roles in inflammation and CVD risk, and to investigate associations between these and systemic inflammation. METHODS: In a screening cohort including 14 HIV-1-infected individuals and nine uninfected controls microarray profiling was performed using peripheral blood mononuclear cells (PBMC)...
October 3, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27748825/identification-and-bioinformatic-analysis-of-dysregulated-micrornas-in-human-oligodendroglial-cells-infected-with-borna-disease-virus
#8
Hong Zhang, Peng He, Rongzhong Huang, Lin Sun, Siwen Liu, Jingjing Zhou, Yujie Guo, Deyu Yang, Peng Xie
MicroRNAs (miRNAs) are recognized as important regulators of gene expression via translational depression or mRNA degradation. Previously, dysregulated miRNAs have been found in neurodegenerative and neuropsychiatric disorders. Borna disease virus (BDV) is a neurotropic, negative single‑stranded RNA virus, which may be a cause of human neuropsychiatric disease. BDV is regarded as an ideal model to analyze the molecular mechanisms of mental disorders caused by viral infection. In the present study, 10 miRNAs were dysregulated in human oligodendrocytes (OL cells) infected with the BDV strain, Hu‑H1 (OL/BDV)...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27743454/the-role-of-micrornas-in-islet-%C3%AE-cell-development
#9
REVIEW
Maryam Kaviani, Negar Azarpira, Mohammad Hossein Karimi, Ismail Al-Abdullah
Cell-based therapies suggest novel treatments to overcome the complication of the current therapeutic approaches in diabetes mellitus type 1. Replacement of the destroyed pancreatic islet β-cells by appropriate alternative cells needs an efficient approach to differentiate the cells into viable and functional insulin producing cells. Small non-coding RNA molecules, microRNAs (miRNA), have critical roles in post-transcriptional regulation of gene expression. Therefore, they can direct the cells toward β-cell like cells and control islet β-cell development...
October 15, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27720656/microrna-375-as-a-biomarker-for-malignant-transformation-in-oral-lesions
#10
Amani M Harrandah, Sarah G Fitzpatrick, Molly H Smith, Dunrui Wang, Donald M Cohen, Edward K L Chan
OBJECTIVE: Malignant transformation of oral premalignant lesions is the key process in the progression to oral squamous cell carcinoma (OSCC). Previously, we identified miR-7 and miR-21 as candidate oncogenes and miR-375 and miR-494 as candidate tumor suppressors in OSCC. We aim to evaluate these microRNAs as biomarkers of malignant transformation in oral premalignant lesions. STUDY DESIGN: Formalin-fixed, paraffin-embedded samples from progressive premalignant lesions and paired sequential OSCC tumors at the same site were obtained from same patients (n = 31)...
December 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27642589/circular-rna-itch-suppresses-lung-cancer-proliferation-via-inhibiting-the-wnt-%C3%AE-catenin-pathway
#11
Li Wan, Lin Zhang, Kai Fan, Zai-Xing Cheng, Quan-Chao Sun, Jian-Jun Wang
As a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge. While the function of circular RNA-ITCH (cir-ITCH) in lung cancer is still less reported, in this study, we firstly detected the expression of cir-ITCH in tumor tissues and paired adjacent noncancer tissues of 78 patients with lung cancer using a TaqMan-based quantitative real-time PCR (qRT-PCR). The results showed that the expression of cir-ITCH was significantly decreased in lung cancer tissues...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27633373/microrna-7-inhibits-proliferation-migration-and-invasion-of-thyroid-papillary-cancer-cells-via-targeting-cks2
#12
Kaiyao Hua, Jiali Jin, Huiwen Zhang, Bingkun Zhao, Chenyang Wu, Hui Xu, Lin Fang
The purpose of this study was to examine the expression levels of microRNA-7 (miR-7) in human thyroid papillary cancer and its potential role in disease pathogenesis. The expression levels of different miRNAs were detected by miRNA-microarray analysis in ten thyroid papillary cancer specimens and adjacent normal thyroid cancer tissues. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to determine the expression level of miR-7 in both thyroid papillary cancer tissues and cell lines...
August 18, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27614453/the-circular-rna-cirs-7-cdr1as-acts-as-a-risk-factor-of-hepatic-microvascular-invasion-in-hepatocellular-carcinoma
#13
Liangliang Xu, Ming Zhang, Xiaobo Zheng, Pengsheng Yi, Chuan Lan, Mingqing Xu
PURPOSE: Circular RNAs (circRNA) represent a novel class of widespread and diverse endogenous RNAs that regulate gene expression in mammals. microRNA-7 (miR-7) is a well-demonstrated suppressor of hepatocellular carcinoma (HCC). Recent studies have showed that one such circRNA, ciRS-7 (also termed as Cdr1as) was the inhibitor and sponge of miR-7 in the embryonic zebrafish midbrain and islet cells. However, the relationships among ciRS-7, miR-7 and clinical features of HCC remain to be clarified...
September 10, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27583982/microrna-7-regulates-il-1%C3%AE-induced-extracellular-matrix-degeneration-by-targeting-gdf5-in-human-nucleus-pulposus-cells
#14
Wei Liu, Yukun Zhang, Ping Xia, Shuai Li, Xintong Feng, Yong Gao, Kun Wang, Yu Song, Zhenfeng Duan, Shuhua Yang, Zengwu Shao, Cao Yang
The precise role of interleukin-1 beta (IL-1β)-induced extracellular matrix degeneration in the pathogenesis of intervertebral disc degeneration (IDD) is currently unknown. Recent evidence has revealed that microRNAs (miRNAs) are associated with IDD, but their function in the extracellular matrix degradation of nucleus pulposus (NP) tissues is also poorly understood. The aim of this study was to evaluate the expression and functional role of miR-7 in IL-1β-induced disc degeneration. The expression level of miR-7 was investigated in degenerative NP tissues and in IL-1β-induced NP cells using quantitative reverse transcription-polymerase chain reaction amplification analysis...
August 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27566954/prognostic-value-of-a-bcsc-associated-microrna-signature-in-hormone-receptor-positive-her2-negative-breast-cancer
#15
Chang Gong, Weige Tan, Kai Chen, Na You, Shan Zhu, Gehao Liang, Xinhua Xie, Qian Li, Yunjie Zeng, Nengtai Ouyang, Zhihua Li, Musheng Zeng, ShiMei Zhuang, Wan-Yee Lau, Qiang Liu, Dong Yin, Xueqin Wang, Fengxi Su, Erwei Song
PURPOSE: Breast cancer patients with high proportion of cancer stem cells (BCSCs) have unfavorable clinical outcomes. MicroRNAs (miRNAs) regulate key features of BCSCs. We hypothesized that a biology-driven model based on BCSC-associated miRNAs could predict prognosis for the most common subtype, hormone receptor (HR)-positive, HER2-negative breast cancer patients. PATIENTS AND METHODS: After screening candidate miRNAs based on literature review and a pilot study, we built a miRNA-based classifier using LASSO Cox regression method in the training group (n=202) and validated its prognostic accuracy in an internal (n=101) and two external validation groups (n=308)...
September 2016: EBioMedicine
https://www.readbyqxmd.com/read/27542248/landscape-of-rnas-in-human-lumbar-disc-degeneration
#16
Ping-Heng Lan, Zhi-Heng Liu, Yan-Jun Pei, Zhi-Gang Wu, Yang Yu, Yong-Feng Yang, Xu Liu, Lu Che, Chi-Jiao Ma, Yan-Ke Xie, Qing-Jie Hu, Zhong-Yuan Wan, Hai-Qiang Wang
Accumulating evidence indicates noncoding RNAs (ncRNAs) fine-tune gene expression with mysterious machinery. We conducted a combination of mRNA, miRNA, circRNA, LncRNA microarray analyses on 10 adults' lumbar discs. Moreover, we performed additional global exploration on RNA interacting machinery in terms of in silico computational pipeline. Here we show the landscape of RNAs in human lumbar discs. In general, the RNA-abundant landscape comprises 14,635 mRNAs (37.93%), 2,059 miRNAs (5.34%), 18,995 LncRNAs (49...
August 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27533461/microrna-744-3p-promotes-mmp-9-mediated-metastasis-by-simultaneously-suppressing-pdcd4-and-pten-in-laryngeal-squamous-cell-carcinoma
#17
John Zeng-Hong Li, Wei Gao, Wen-Bin Lei, Jing Zhao, Jimmy Yu-Wai Chan, William Ignace Wei, Wei-Kuen Ho, Thian-Sze Wong
MicroRNA controls cancer invasion by governing the expression of gene regulating migration and invasion. Here, we reported a novel regulatory pathway controlled by miR-744-3p, which enhanced expression of matrix metallopeptidase 9 (MMP-9) in laryngeal squamous cell carcinoma (LSCC). We profiled the differential micoRNA expression pattern in LSCC cell lines and normal epithelial cultures derived from the head and neck mucosa using microRNA microarray. MiR-7-1-3p, miR-196a/b and miR-744-3p were expressed differentially in the LSCC cell lines...
August 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27519414/suppression-of-microrna-7-mir-7-biogenesis-by-nuclear-factor-90-nuclear-factor-45-complex-nf90-nf45-controls-cell-proliferation-in-hepatocellular-carcinoma
#18
Takuma Higuchi, Hiroshi Todaka, Yasunori Sugiyama, Masafumi Ono, Nobuyuki Tamaki, Etsuro Hatano, Yuka Takezaki, Kazuhiro Hanazaki, Takeshi Miwa, Sylvia Lai, Keiko Morisawa, Masayuki Tsuda, Taketoshi Taniguchi, Shuji Sakamoto
MicroRNA-7 (miR-7)has been characterized as an anti-oncogenic microRNA (miRNA) in several cancers, including hepatocellular carcinoma (HCC). However, the mechanism for the regulation of miR-7 production in tumors remains unclear. Here, we identified nuclear factor 90 (NF90) and NF45 complex (NF90-NF45) as negative regulators of miR-7 processing in HCC. Expression of NF90 and NF45 was significantly elevated in primary HCC tissues compared with adjacent non-tumor tissues. To examine which miRNAs are controlled by NF90-NF45, we performed an miRNA microarray and quantitative RT-PCR analyses of HCC cell lines...
September 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27450756/circular-rnas-and-systemic-lupus-erythematosus
#19
REVIEW
Lian-Ju Li, Qing Huang, Hai-Feng Pan, Dong-Qing Ye
Circular RNAs (circRNAs) are a large class of noncoding RNAs that form covalently closed RNA circles. The discovery of circRNAs discloses a new layer of gene regulation occurred post-transcriptionally. Identification of endogenous circRNAs benefits from the advance in high-throughput RNA sequencing and remains challenging. Many studies probing into the mechanisms of circRNAs formation occurred cotranscriptionally or posttranscriptionally emerge and conclude that canonical splicing mechanism, sequence properties, and certain regulatory factors are at play in the process...
August 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27448964/mir-7-reverses-the-resistance-to-brafi-in-melanoma-by-targeting-egfr-igf-1r-craf-and-inhibiting-the-mapk-and-pi3k-akt-signaling-pathways
#20
Xiaoyan Sun, Jun Li, Yanhong Sun, Yi Zhang, Liyun Dong, Chen Shen, Liu Yang, Ming Yang, Yan Li, Guanxin Shen, Yating Tu, Juan Tao
MicroRNAs (miRNAs) are attractive therapeutic targets for various therapy-resistant tumors. However, the association between miRNA and BRAF inhibitor resistance in melanoma remains to be elucidated. We used microarray analysis to comprehensively study the miRNA expression profiling of vemurafenib resistant (VemR) A375 melanoma cells in relation to parental A375 melanoma cells. MicroRNA-7 (miR-7) was identified to be the most significantly down-regulated miRNA in VemR A375 melanoma cells. We also found that miR-7 was down-regulated in Mel-CVR cells (vemurafenib resistant Mel-CV melanoma cells)...
July 18, 2016: Oncotarget
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