Lise Lotte Christensen, Kirsten True, Mark P Hamilton, Morten M Nielsen, Nkerorema D Damas, Christian K Damgaard, Halit Ongen, Emmanouil Dermitzakis, Jesper B Bramsen, Jakob S Pedersen, Anders H Lund, Søren Vang, Katrine Stribolt, Mogens R Madsen, Søren Laurberg, Sean E McGuire, Torben F Ørntoft, Claus L Andersen
It is well established that lncRNAs are aberrantly expressed in cancer where they have been shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal adenomas/adenocarcinomas and 292 adjacent normal colon mucosa samples using RNA-sequencing demonstrated that the snoRNA host gene 16 (SNHG16) is significantly up-regulated in adenomas and all stages of CRC. SNHG16 expression was positively correlated to the expression of Wnt-regulated transcription factors, including ASCL2, ETS2, and c-Myc...
October 2016: Molecular Oncology