Ashley I Heinson, Jeongmin Woo, Amey Mukim, Cory H White, Bastiaan Moesker, Alberto Bosque, Celsa Spina, Christopher H Woelk, Ben D Macarthur, Nadejda Beliakova-Bethell
Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, non-coding genes have been implicated in regulation of HIV expression. In the present study, small RNA sequencing was used to profile expression of micro RNAs (miRNAs) in a primary CD4+ T cell <i>in vitro</i> model of HIV latency. Previously, we have shown that protein-coding genes dysregulated in this model were enriched for the p53 signalling pathway, which was confirmed experimentally...
October 12, 2020: AIDS Research and Human Retroviruses