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Differentiated thyroid cancer

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https://www.readbyqxmd.com/read/29050318/unanticipated-prognosis-of-differential-thyroid-cancer-patients-with-t0-stage-analysis-of-the-seer-database-2004-2013
#1
Chunping Liu, Jie Ming, Wen Zeng, Shuntao Wang, Yiquan Xiong, Qiuyang Zhao, Xingjie Yin, Zeming Liu, Tao Huang
The prognosis of T0 stage differentiated thyroid cancer (DTC) remains unclear. This study aimed to investigate the prognosis of T0 stage DTC patients to provide a new perspective on treatment guidelines for these patients. We investigated a large cohort of DTC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Patient survival curves were examined by Kaplan-Meier analyses with log-rank tests and Cox proportional hazards regression analyses. In the study cohort, the rate of cancer-specific mortality per 1000 person-years for T0 was higher than T1-T3, but lower than T4...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049252/prognostic-role-of-fdg-pet-ct-in-patients-with-differentiated-thyroid-cancer-treated-with-131-iodine-empiric-therapy
#2
Barbara Salvatore, Michele Klain, Emanuele Nicolai, Domenico D'Amico, Gianluca De Matteis, Marco Raddi, Rosa Fonti, Teresa Pellegrino, Giovanni Storto, Alberto Cuocolo, Leonardo Pace
BACKGROUND: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). METHODS: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 ± 5 years after empiric RAI therapy were retrospectively analyzed...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048237/lenvatinib-for-the-treatment-of-radio-iodine-refractory-thyroid-cancer-in-real-life-practice
#3
Amandine Berdelou, Isabelle Borget, Yann Godbert, Thierry Nguyen, Marie-Eve Garcia, Cecile N Chougnet, Aurélie Ferru, Camille Buffet, Olivier Chabre, Olivier Huillard, Sophie Leboulleux, Martin Schlumberger
BACKGROUND: In the SELECT phase III trial in advanced radio-iodine refractory differentiated thyroid cancer (rDTC), lenvatinib improved median progression free survival (PFS) over placebo by almost 15 months and induces an objective response rate of 64.8%, but adverse events occurred in almost all patients. The present study evaluates the efficacy and toxicity of lenvatinib treatment in real-life practice. METHODS: Clinical charts of 88 consecutive patients treated with lenvatinib from July 2015 to June 2016 in 27 French centers were retrospectively reviewed...
October 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29042396/differentiated-thyroid-cancer-millions-spent-with-no-tangible-gain
#4
Luis Furuya-Kanamori, Art Sedrakyan, Adedayo A Onitilo, Nasser Bagheri, Paul Glasziou, Suhail A R Doi
The incidence of differentiated thyroid cancer (DTC) has rapidly increased worldwide over the last decades. It is unknown if the increase in diagnosis has been mirrored by an increase in thyroidectomy rates with the concomitant economic impact that this would have on the healthcare system. DTC and thyroidectomy incidence as well as DTC specific mortality were modelled using Poisson regression in New South Wales (NSW), Australia per year and by sex. The incidence of 2002 was the point from which the increase in rates were assessed cumulatively over the subsequent decade...
October 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29040691/differential-growth-rates-of-benign-versus-malignant-thyroid-nodules
#5
Trevor E Angell, Chirag Vyas, Marco Medici, Zhihong Wang, Justine A Barletta, Carol B Benson, Edmund S Cibas, Nancy L Cho, Gerard M Doherty, Peter M Doubilet, Mary C Frates, Atul A Gawande, Howard T Heller, Matthew I Kim, Jeffrey F Krane, Ellen Marqusee, Francis D Moore, Matt A Nehs, Ann Marie Zavacki, P Reed Larsen, Erik K Alexander
Context: Thyroid nodule growth was once considered concerning for malignancy, but data showing that benign nodules grow questioned the utility of this paradigm. To date, however, no studies have adequately evaluated if growth rates differ in malignant versus benign nodules. Objective: To sonographically evaluate growth rates in benign and malignant thyroid nodules ≥1cm. Design: Prospective, cohort study of patients with tissue diagnosis of benign or malignant disease, with repeated ultrasound evaluation six or more months apart...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29039144/transoral-endoscopic-thyroidectomy-via-a-vestibular-approach-why-and-how
#6
Gianlorenzo Dionigi, Young Jun Chai, Ralph P Tufano, Angkoon Anuwong, Hoon Yub Kim
The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a novel, scar-free surgical procedure that does not require visible incisions. Indications for TOETVA are as follows: predicted gland width on diagnostic imaging ≤10 cm; a thyroid volume outline of <45 mL or dominant nodule dimension of ≤50 mm; three or four Bethesda lesions; a primary papillary microcarcinoma without local or distant metastasis; and patient request for optimal esthetic results. Contraindications are as follows: patients unfit for general anesthesia; precedent radiation in the head, neck, upper mediastinum; antecedent neck surgery; recurrent goiter; a gland volume of >45 mL or main nodule diameter of >50 mm; and documentation of lymph node or distant metastases, tracheal/esophageal infiltration, preoperative laryngeal nerve palsy, hyperthyroidism, mediastinal goiter, or an oral abscess...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29032724/reintroducing-the-sodium-iodide-symporter-nis-to-anaplastic-thyroid-carcinoma
#7
Kathrin Alexandra Schmohl, Patrick Dolp, Christina Schug, Kerstin Knoop, Kathrin Klutz, Nathalie Schwenk, Peter Bartenstein, Peter Jon Nelson, Manfred Ogris, Ernst Wagner, Christine Spitzweg
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodide therapy. In the current study, we aimed to extend the diagnostic and therapeutic application of radioiodide beyond the treatment of differentiated thyroid cancer by targeting the functional sodium iodide symporter (NIS) to ATC. We employed nanoparticle vectors (polyplexes) based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG) and coupled to the synthetic peptide GE11 as an epidermal growth factor receptor (EGFR)-specific ligand in order to target a <i>NIS</i>-expressing plasmid (LPEI-PEG-GE11/NIS) to EGFR overexpressing human thyroid carcinoma cell lines...
October 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29030773/outcome-prediction-with-the-revised-american-joint-committee-on-cancer-staging-system-and-american-thyroid-association-guidelines-for-thyroid-cancer
#8
Sunghwan Suh, Yun Hak Kim, Tae Sik Goh, Jin Lee, Dae Cheon Jeong, Sae-Ock Oh, Jong Chul Hong, Seong Jang Kim, In Joo Kim, Kyoungjune Pak
BACKGROUND: Several staging systems have been developed to predict the risk of mortality in patients with differentiated thyroid cancer (DTC). However, none of them have been shown to be clearly superior to the other. METHODS: We compared the patient outcome predictability of recently revised staging systems predictability of patient outcome using data from The Cancer Genome Atlas. To set a comparison among American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging 7th, 8th editions, American Thyroid Association guidelines 2009 and 2015, concordance index (c-index), Akaike information criterion (AIC), Bayesian information criterion (BIC), and Brier score were applied to quantify the predictive ability of a survival model, to select the statistical model, and to measure the accuracy of probabilistic predictions...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29028645/an-update-on-the-status-of-molecular-testing-for-the-indeterminate-thyroid-nodule-and-risk-stratification-of-differentiated-thyroid-cancer
#9
Kristina J Nicholson, Linwah Yip
PURPOSE OF REVIEW: Correct identification of malignancy in cytologically indeterminate thyroid nodules is a diagnostic challenge, leading to potentially unnecessary surgery in patients for whom final histology is benign. Similarly, many patients with differentiated thyroid cancer (DTC) undergo aggressive surgical management of tumors, which may ultimately have low-risk histologic features. Use of molecular testing strategies can aid in both the diagnosis of indeterminate thyroid nodules and preoperative risk stratification of DTC...
October 11, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29027288/cxxc5-expression-in-prostate-cancer-implications-for-cancer-progression
#10
Ines Benedetti, Angelo M De Marzo, Jan Geliebter, Niradiz Reyes
Identification of genes specifically deregulated in prostate adenocarcinoma may lead to discovery of new oncogenes/tumour suppressors with clinical relevance for diagnosis, prognosis and/or therapy. CXXC5 is a gene encoding a retinoid-inducible nuclear factor, whose overexpression in breast tumours, metastatic malignant melanomas and papillary thyroid carcinoma has been recently reported. We previously found differential expression of CXXC5 transcripts in metastatic prostate cancer cell lines of both rat and human origin...
August 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29026128/risk-of-malignancy-in-thyroid-nodules-predictive-value-of-puncture-feeling-of-grittiness-in-the-process-of-fine-needle-aspiration
#11
Jieli Luo, Chao Zhang, Fengbo Huang, Jianshe Chen, Yang Sun, Kailun Xu, Pintong Huang
Fine-needle aspiration cytology (FNAC) is widely used for diagnosing thyroid nodules. However, there has been no specific investigation about the puncture feeling of grittiness. The aim of the present study was to see if the puncture feeling of grittiness during fine-needle aspiration procedure, combined with standard FNAC, could improve the accuracy in diagnosing thyroid cancer. A total of one thousand five hundred and thirty-one thyroid FNAC specimens acquired between January 2013 and January 2017 were retrospectively retrieved...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025766/car-t-therapy-targeting-icam-1-eliminates-advanced-human-thyroid-tumors
#12
Irene M Min, Enda Shevlin, Yogindra Vedvyas, Marjan Zaman, Brian Wyrwas, Theresa Scognamiglio, Maureen D Moore, Weibin Wang, Susan Park, Spencer Park, Suraj Panjwani, Katherine D Gray, Andrew B Tassler, Rasa Zarnegar, Thomas J Fahey, Moonsoo M Jin
PURPOSE: Poorly-differentiated thyroid cancer and anaplastic thyroid cancer (ATC) are rare yet lethal malignancies with limited treatment options. Many malignant tumors including papillary thyroid cancer (PTC) and ATC are associated with increased expression of ICAM-1, providing a rationale for utilizing ICAM-1-targeting agents for the treatment of aggressive cancer. We developed a third-generation CAR targeting ICAM-1 to leverage adoptive T cell therapy as a new treatment modality. EXPERIMENTAL DESIGN: ICAM-1 CAR T cells were applied on multiple malignant and non-malignant target cells to investigate specific target cell death and 'off-tumor' toxicity in vitro...
October 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29020892/are-evidence-based-guidelines-reflected-in-clinical-practice-an-analysis-of-prospectively-collected-data-of-the-italian-thyroid-cancer-observatory-itco-1
#13
Livia Lamartina, Cosimo Durante, Giuseppe Lucisano, Giorgio Grani, Rocco Alfonso Bellantone, Celestino Pio Lombardi, Alfredo Pontecorvi, Emanuela Arvat, Francesco Felicetti, Maria Chiara Zatelli, Roberta Rossi, Efisio Puxeddu, Silvia Morelli, Massimo Torlontano, Umberto Crocetti, Teresa Montesano, Raffaele Giubbini, Fabio Orlandi, Gianluca Aimaretti, Fabio Monzani, Marco Attard, Cecilia Francese, Alessandro Antonelli, Paolo P Limone, Ruth Rossetto, Laura Fugazzola, Domenico Meringolo, Rocco Bruno, Salvatore Tumino, Graziano Ceresini, Marco Centanni, Salvatore Monti, Domenico Salvatore, Caterina Mian, Giovanna Spiazzi, Luca Persani, Daniele Barbaro, Antonio Nicolucci, Sebastiano Filetti
OBJECTIVES: The goal of evidence-based practice guidelines is to optimize the management of emerging diseases, such as differentiated thyroid cancer (DTC). The aim of this study was to assess therapeutic approaches for DTC in Italy and to see how closely these practices conformed to those recommended in the 2009 American Thyroid Association (ATA) guidelines. METHODS: The Italian Thyroid Cancer Observatory (ITCO) was established to prospectively collect data on thyroid cancers consecutively diagnosed in participating centers (uniformly distributed across the nation)...
October 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29019044/hobnail-variant-of-papillary-thyroid-carcinoma-a-literature-review
#14
REVIEW
Francesca Ambrosi, Alberto Righi, Costantino Ricci, Lori A Erickson, Ricardo V Lloyd, Sofia Asioli
Papillary thyroid carcinoma is the most common thyroid malignancy and it is usually associated with a good prognosis. However, recurrence, metastases, and cancer death may occur in 10 to 15% of patients with more aggressive types of papillary thyroid carcinoma, such as tall cell, columnar cell, solid variant, or the more recently described hobnail variant of papillary thyroid carcinoma. Papillary thyroid carcinoma with a prominent hobnail pattern is a moderately differentiated papillary thyroid carcinoma variant with aggressive clinical behavior and significant mortality...
October 10, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/29018997/gastrointestinal-perforation-related-to-lenvatinib-an-anti-angiogenic-inhibitor-that-targets-multiple-receptor-tyrosine-kinases-in-a-patient-with-metastatic-thyroid-cancer
#15
Emi Date, Kunio Okamoto, Souichi Fumita, Hiroyasu Kaneda
Lenvatinib, a novel potent multikinase inhibitor, was approved for the treatment of radioiodine-refractory differentiated thyroid cancer based on results from phase III trial (SELECT study). Thyroid cancer is a diverse disease that includes anaplastic thyroid cancer (ATC), which the most aggressive form of the disease, although it accounts for <2% of all thyroid cancers. Current treatments for ATC have limited efficacy. We report the case of a woman with recurrent well-differentiated papillary carcinoma of the thyroid that had transformed into ATC who developed a perforation of the small intestine secondary to a marked effect of lenvatinib...
October 11, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28990511/sunitinib-in-the-treatment-of-thyroid-cancer
#16
Ferrari Silvia Martinaa, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro, Fallahi Poupak
BACKGROUND: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28988510/tyrosine-kinase-inhibitors-rechallenge-in-solid-tumors-a-review-of-literature-and-a-case-description-with-lenvatinib-in-thyroid-cancer
#17
Francesco Felicetti, Alice Nervo, Alessandro Piovesan, Rita Berardelli, Filippo Marchisio, Marco Gallo, Emanuela Arvat
In the last decade tyrosine kinase inhibitors (TKIs) have been employed for a wide range of hematological and solid tumors and today they represent a valid therapeutic option for different neoplasms. Among them, both sorafenib and lenvatinib were approved for the treatment of radioactive iodine (RAI) refractory differentiated thyroid carcinoma (DTC). Unfortunately, in some cases the efficacy of TKIs is limited by the onset of drug resistance after the initial response. Areas Covered: We report the case of a patient with a RAI refractory advanced DTC, treated with lenvatinib after surgery, multiple RAI administrations, traditional chemotherapy, and sorafenib...
October 9, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28988434/maternal-and-obstetrical-outcome-in-35-cases-of-well-differentiated-thyroid-carcinoma-during-pregnancy
#18
Jan Boucek, Jorine de Haan, Michael J Halaska, Jan Plzak, Kristel Van Calsteren, Christianne J M de Groot, Karina Dahl Steffensen, Robert Fruscio, Elske T Massolt, Philipp Klaritsch, Paolo Zola, Frédéric Amant
OBJECTIVES/HYPOTHESIS: Thyroid cancer, with 6% to 10% of cancer diagnoses, is one of the most common malignancies during pregnancy. Its treatment poses a risk for the pregnancy, as the thyroid gland plays a crucial role in the evolution of pregnancy. The aim of this study is to evaluate treatment of primary well-differentiated thyroid carcinoma during pregnancy and fetal and maternal outcomes. STUDY DESIGN: This is an international cohort study. METHODS: Primary thyroid cancer patients were identified from the database of the International Network on Cancer, Infertility, and Pregnancy registration study...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987791/serum-interleukin-measurement-may-help-identify-thyroid-cancer-patients-with-active-disease
#19
Mariana Bonjiorno Martins, Marjory Alana Marcello, Fernando de Assis Batista, Karina Colombera Peres, Murilo Meneghetti, Mirela Andrea Latham Ward, Elba Cristina Sá de Camargo Etchebehere, Ligia Vera Montali da Assumpção, Laura Sterian Ward
BACKGROUND: Investigate the clinical utility of serum interleukin dosages of IL-2, IL-2R, IL-4, IL-6, IL-6R, IL-8, IL-10 and IL-12 in the diagnosis and characterization of patients with DTC. In particular, verify ILs utility in the identification of individuals who are evolving disease-free or with the active disease. METHODS: We evaluated 200 patients with malignant nodules (100 patients disease-free and 100 patients with recurrence/active disease); 60 benign nodules and 100 healthy controls, serum levels were assessed by ELISA...
October 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28986753/toward-a-new-and-noninvasive-diagnostic-method-of-papillary-thyroid-cancer-by-using-peptide-vectorized-contrast-agents-targeted-to-galectin-1
#20
Deborah Fanfone, Nadège Despretz, Dimitri Stanicki, Jenifer Rubio-Magnieto, Mathieu Fossépré, Mathieu Surin, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Sophie Laurent, Robert N Muller, Sven Saussez, Carmen Burtea
The incidence of papillary thyroid cancer has increased these last decades due to a better detection. High prevalence of nodules combined with the low incidence of thyroid cancers constitutes an important diagnostic challenge. We propose to develop an alternative diagnostic method to reduce the number of useless and painful thyroidectomies using a vectorized contrast agent for magnetic resonance imaging. Galectin-1 (gal-1), a protein overexpressed in well-differentiated thyroid cancer, has been targeted with a randomized linear 12-mer peptide library using the phage display technique...
October 6, 2017: Medical Oncology
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