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Differentiated thyroid cancer

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https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#1
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#2
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28079945/systematic-review-of-site-distribution-of-bone-metastases-in-differentiated-thyroid-cancer
#3
REVIEW
Marcela Osorio, Sami P Moubayed, Henry Su, Mark L Urken
BACKGROUND: Thyroid cancer is the fastest growing cancer in the United States. A small portion of differentiated thyroid cancers (DTCs; 2% to 13%) develop bone metastases, which can decrease a patient's survival rate by more than 60%. METHODS: A systematic literature search of studies, including patients with DTC with bone metastases, was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A case series of patients with DTC diagnosed with bone metastases seen at our institution was also included...
January 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28076008/pictorial-review-of-false-positive-results-on-radioiodine-scintigrams-of-patients-with-differentiated-thyroid-cancer
#4
Amy V Chudgar, Jagruti C Shah
Radioiodine has served an important role in the diagnostic workup and treatment of patients with differentiated thyroid cancer for more than 6 decades. The interpretation of radioiodine scintigraphic studies should be performed in conjunction with a comprehensive history, histopathologic correlation, and pertinent laboratory values, as well as correlation with available anatomic images and the findings from physical examination. A thorough understanding of the physiology and biodistribution of radioiodine is critical when interpreting radioiodine scintigraphic studies to avoid misinterpretation of physiologic and nonthyroid pathologic variants as thyroid cancer metastases...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28072581/-131-i-activity-quantification-of-gamma-camera-planar-images
#5
Raquel Barquero, Hugo P Garcia, Monica G Incio, Pablo Minguez, Alexander Cardenas, Daniel Martínez, Michael Lassmann
A procedure to estimate the activity in target tissues in patients during the therapeutic administration of (131)I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq(-1)) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28071623/differentiated-thyroid-cancer-in-iran-initial-observations-histological-features-management-of-the-disease-and-tumor-recurrence-a-review-of-1689-cases
#6
M Moslehi, Z Shahi, S Badihian, P Jalalpour, M Sedghian, G Motamedi, G Tavakol
AIM: The main objective of this study was to define some histopathological aspects of differentiated thyroid cancer (DTC), describe the disease management, and evaluate potential predicting factors for tumor recurrence in Iran. MATERIALS AND METHODS: Medical records of 1689 patients of DTC treated over a 15-year period at a referral hospital located in the central region of Iran were reviewed retrospectively. RESULTS: The female/male ratio was 3...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28054519/radioiodine-as-an-adjuvant-therapy-and-its-role-in-follow-up-of-differentiated-thyroid-cancer
#7
REVIEW
S Padma, P Shanmuga Sundaram
Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28050206/thyroid-carcinoma-pattern-presentation-according-to-age
#8
Fábio Muradás Girardi
Introduction Patients with thyroid cancer in different age groups present with different prognosis. Objective The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. Methods This is a retrospective study. From 2000 to 2010, 623 patients underwent thyroidectomy for cancer in our institution, with 596 enrolled. Patients were divided into groups of 10 years and then in four age subgroups (≤ 24, 25-44, 45-64, and ≥65 years) for statistical analysis...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28048806/su-g-iep4-05-experience-with-a-practical-approach-to-the-release-of-radioactive-patients-from-radiation-safety-isolation
#9
R Wendt, W Erwin, A Fisher, S Jones, S Jimenez, F Wong, A Jessop
PURPOSE: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients' instructions were. METHODS: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043744/thyroid-stimulating-hormone-suppression-in-the-long-term-follow-up-of-differentiated-thyroid-cancer
#10
B Freudenthal, G R Williams
Differentiated thyroid cancer is the most common form of thyroid cancer and its prognosis is favourable in most cases. Suppression of thyroid stimulating hormone (TSH) by supra-physiological thyroid hormone replacement has been the mainstay of long-term management for over 60 years. However, evidence for a beneficial outcome of TSH suppression is conflicting and intervention must be balanced against adverse effects, particularly affecting the cardiovascular system and skeleton. Here we discuss the role of TSH suppression in the long-term management of differentiated thyroid cancer in the context of risk stratification for disease recurrence and the latest clinical guidelines...
December 30, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28039715/identification-of-differential-pathways-in-papillary-thyroid-carcinoma-utilizing-pathway-co-expression-analysis
#11
Wei-Hai Qiu, Gui-Yan Chen, Lu Cui, Ting-Ming Zhang, Feng Wei, Yong Yang
PURPOSE: To identify differential pathways between papillary thyroid carcinoma (PTC) patients and normal controls utilizing a novel method which combined pathway with co-expression network. METHODS: The proposed method included three steps. In the first step, we conducted pretreatments for background pathways and gained representative pathways in PTC. Subsequently, a co-expression network for representative pathways was constructed using empirical Bayes (EB) approach to assign a weight value for each pathway...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28039458/multicellular-spheroids-from-normal-and-neoplastic-thyroid-tissues-as-a-suitable-model-to-test-the-effects-of-multikinase-inhibitors
#12
Valentina Cirello, Valentina Vaira, Elisa Stellaria Grassi, Valeria Vezzoli, Dario Ricca, Carla Colombo, Silvano Bosari, Leonardo Vicentini, Luca Persani, Stefano Ferrero, Laura Fugazzola
Multicellular three-dimensional (3D) spheroids represent an experimental model that is intermediate in its complexity between monolayer cultures and patients' tumor. In the present study, we characterize multicellular spheroids from papillary (PTC) and follicular (FTC) thyroid cancers and from the corresponding normal tissues. We show that these 3D structures well recapitulate the features of the original tissues, in either the differentiated and "stem-like" components. As a second step, we were aimed to test the effects of a small multikinase inhibitor, SP600125 (SP), previously shown to efficiently induce cell death in undifferentiated thyroid cancer monolayer cultures...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28036261/circulating-thyroid-stimulating-hormone-receptor-messenger-rna-and-differentiated-thyroid-cancer-a-diagnostic-meta-analysis
#13
Zhen-Zhen Zhang, Qiang Chen, Chao-Yue Kong, Zhan-Ming Li, Li-Shun Wang
Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030816/down-regulation-of-14q32-encoded-mirnas-and-tumor-suppressor-role-for-mir-654-3p-in-papillary-thyroid-cancer
#14
Murilo Vieira Geraldo, Helder Imoto Nakaya, Edna Teruko Kimura
Papillary thyroid carcinoma (PTC) is the most prevalent malignant neoplasia of the thyroid gland. A fraction of PTC cases show loss of differentiation and aggressive behavior, with radioiodine therapy resistance and metastasis. Although microRNAs (miRNAs) emerged as promising molecular markers for PTC, their role in the loss of differentiation observed during PTC progression remains to be fully understood. We performed the large-scale analysis of miRNA expression during PTC progression in BRAFT1799A-transgenic animals (Tg-Braf) and thyroid cancer cell lines and identified the marked downregulation of several miRNAs from the region 14q32...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025634/regional-variation-across-canadian-centers-in-radioiodine-administration-for-thyroid-remnant-ablation-in-well-differentiated-thyroid-cancer-diagnosed-in-2000-2010
#15
I Rachinsky, M Rajaraman, W D Leslie, A Zahedi, C Jefford, A McGibbon, J E M Young, K A Pathak, M Badreddine, S De Brabandere, H Fong, S Van Uum
Background. Use of radioactive iodine (RAI) ablation has been reported to vary significantly between studies. We explored variation in RAI ablation care patterns between seven thyroid cancer treatment centers in Canada. Methods. The Canadian Collaborative Network for Cancer of the Thyroid (CANNECT) is a collaborative registry to describe and analyze patterns of care for thyroid cancer. We analyzed data from seven participating centers on RAI ablation in patients diagnosed with well-differentiated (papillary and follicular) thyroid cancer between 2000 and 2010...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28011713/germline-compound-heterozygous-poly-glutamine-deletion-in-usf3-may-be-involved-in-predisposition-to-heritable-and-sporadic-epithelial-thyroid-carcinoma
#16
Ying Ni, Spencer Seballos, Benjamin Fletcher, Todd Romigh, Lamis Yehia, Jessica Mester, Leigha Senter, Farshad Niazi, Motoyasu Saji, Matthew D Ringel, Thomas LaFramboise, Charis Eng
Cowden syndrome (CS) is an autosomal dominant disorder that predisposes to breast, thyroid, and other epithelial cancers. Differentiated thyroid carcinoma (DTC), as one of the major component cancers of CS, is the fastest rising incident cancer in the USA, and the most familial of all solid tumors. To identify additional candidate genes of CS and potentially DTC, we analyzed a multi-generation CS-like family with papillary thyroid cancer (PTC), applying a combined linkage-based and whole-genome sequencing strategy and identified an in-frame germline compound heterozygous deletion, p...
December 22, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28011236/micrornas-in-thyroid-development-function-and-tumorigenesis
#17
Cesar Seigi Fuziwara, Edna Teruko Kimura
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that modulate the vast majority of cellular processes. During development, the correct timing and expression of miRNAs in the tissue differentiation is essential for organogenesis and functionality. In thyroid gland, DICER and miRNAs are necessary for accurately establishing thyroid follicles and hormone synthesis. Moreover, DICER1 mutations and miRNA deregulation observed in human goiter influence thyroid tumorigenesis. The thyroid malignant transformation by MAPK oncogenes is accompanied by global miRNA changes, with a marked reduction of "tumor-suppressor" miRNAs and activation of oncogenic miRNAs...
December 21, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28008451/values-of-molecular-markers-in-the-differential-diagnosis-of-thyroid-abnormalities
#18
REVIEW
T M P B Tennakoon, M Rushdhi, A D C U Ranasinghe, R S Dassanayake
INTRODUCTION: Thyroid cancer (TC), follicular adenoma (FA) and Hashimoto's thyroiditis (HT) are three of the most frequently reported abnormalities that affect the thyroid gland. A frequent co-occurrence along with similar histopathological features is observed between TC and FA as well as between TC and HT. The conventional diagnostic methods such as histochemical analysis present complications in differential diagnosis when these abnormalities occur simultaneously. Hence, the authors recognize novel methods based on screening genetic defects of thyroid abnormalities as viable diagnostic and prognostic methods that could complement the conventional methods...
December 22, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28007013/dynamic-risk-estimates-of-outcome-in-chinese-patients-with-well-differentiated-thyroid-cancer-after-total-thyroidectomy-and-radioactive-iodine-remnant-ablation
#19
Feng Chih Shen, Ching-Jung Hsieh, I Chin Huang, Yen Hsiang Chang, Pei Wen Wang
Background This study was conducted to compare the staging systems for the prediction of long-term disease status in patients with well-differentiated thyroid carcinoma (WDTC), and find out the earliest postoperative period predictor of long-term persistence/recurrence of disease. Methods Patients with WDTC (n=356, age 41.5 ± 12.7 years) followed for at least 5 years (12.3 ± 5.0 years) after thyroidectomy and 131I remnant ablation at a tertiary regional hospital in Taiwan were retrospectively studied. Each patient was risk-stratified using the American Joint Cancer Committee (AJCC) (stage I-IV), American Thyroid Association (ATA) (low, intermediate, high risk) staging systems after operation and first 131I remnant ablation and using response to initial therapy reclassification (RTR) (excellent, indeterminate, biochemical incomplete, structural incomplete response) system, which is determined 6-24 months after the first 131I ablation...
December 22, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28004221/overexpression-of-teneurin-transmembrane-protein-1-is-a-potential-marker-of-disease-progression-in-papillary-thyroid-carcinoma
#20
Shih-Ping Cheng, Ming-Jen Chen, Ming-Nan Chien, Chi-Hsin Lin, Jie-Jen Lee, Chien-Liang Liu
Although papillary thyroid cancer is a relatively indolent malignancy, its progression may be associated with dedifferentiation and resistance to radioactive iodine treatment. In this study, patterns of differentially expressed genes in association with disease progression were systemically evaluated. We firstly performed transcriptome analyses for four matched cancerous and noncancerous tissue pairs of the classical subtype of papillary thyroid cancer. Among the upregulated and downregulated genes, the expression of 164 and 183 genes increased and decreased, respectively, from stage I to stage IV...
December 21, 2016: Clinical and Experimental Medicine
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