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Radiation induced secondary malignancy

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https://www.readbyqxmd.com/read/29688510/study-protocol-early-stereotactic-gamma-knife-radiosurgery-to-residual-tumor-after-surgery-of-newly-diagnosed-glioblastoma-gamma-gbm
#1
Stefanie Brehmer, Mario Alexander Grimm, Alex Förster, Marcel Seiz-Rosenhagen, Grit Welzel, Florian Stieler, Frederik Wenz, Christoph Groden, Sabine Mai, Daniel Hänggi, Frank Anton Giordano
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adult patients. Tumor recurrence commonly occurs around the resection cavity, especially after subtotal resection (STR). Consequently, the extent of resection correlates with overall survival (OS), suggesting that depletion of postoperative tumor remnants will improve outcome. OBJECTIVE: To assess safety and efficacy of adding stereotactic radiosurgery (SRS) to the standard treatment of GBM in patients with postoperative residual tumor...
April 24, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29681812/a-58-year-old-woman-with-left-sided-weakness-and-a-history-of-a-pediatric-brain-tumor-a-case-report
#2
Shaakir Hasan, Michael J Gigliotti, Melvin Deutsch, Stacey L Reed, Rodney E Wegner
Background: An uncommon but well-established complication of cranial irradiation is secondary neoplasm. This case presentation documents a radiation-induced malignant glioma 55 years after being diagnosed with "cerebral sarcoma," now defined as atypical meningioma. This not only represents the longest reported latency period for a patient initially receiving over 30 Gy, but also provides a valuable historical perspective of neuro-oncology. Clinical Presentation: A 58-year-old female presenting with progressive left-sided upper and lower extremity weakness with a past medical history significant for "cerebral sarcoma" was diagnosed with glioblastoma multiforme...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29680008/secondary-mucinous-carcinoma-of-the-prostate-after-low-dose-rate-brachytherapy
#3
Sonja C Murchison, Mildred B Martens, Pauline Truong, Abraham Alexander
Radiation induced malignancy (RIM) after treatment for prostate cancer is well documented after external beam irradiation, but less so in the setting of brachytherapy. We report a case of mucinous adenocarcinoma of the prostate, consistent with a RIM, which developed 12 years after low dose rate brachytherapy for low risk prostate adenocarcinoma. Diagnostic and therapeutic considerations of RIM are discussed. As long term survivors are followed in the community by primary care physicians and urologists, awareness of RIM as a potential late effect of brachytherapy is important to ensure that cases are diagnosed and managed appropriately...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29468099/effect-of-gamma-knife-radiosurgery-and-programmed-cell-death-1-receptor-antagonists-on-metastatic-melanoma
#4
Nathan Nordmann, Molly Hubbard, Tyler Nordmann, Paul W Sperduto, H Brent Clark, Matthew A Hunt
Learning objectives To evaluate radiation-induced changes in patients with brain metastasis secondary to malignant melanoma who received treatment with Gamma Knife radiosurgery (GKRS) and programmed cell death 1 (PD-1) receptor antagonists. Introduction  Stereotactic radiosurgery and chemotherapeutics are used together for treatment of metastatic melanoma and have been linked to delayed radiation-induced vasculitic leukoencephalopathy (DRIVL). There have been reports of more intense interactions with new immunotherapeutics targeting PD-1 receptors, but their interactions have not been well described and may result in an accelerated response to GKRS...
December 13, 2017: Curēus
https://www.readbyqxmd.com/read/29432550/strategies-for-prediction-and-mitigation-of-radiation-induced-liver-toxicity
#5
Diego A S Toesca, Bulat Ibragimov, Amanda J Koong, Lei Xing, Albert C Koong, Daniel T Chang
Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and a 'non-classic' form, with liver transaminases elevated to more than five times the reference value, or worsening of liver metabolic function represented as an increase of 2 or more points in the Child-Pugh score classification...
March 1, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29403311/radiation-induced-secondary-malignancies-for-nasopharyngeal-carcinoma-a-pilot-study-of-patients-treated-via-imrt-or-vmat
#6
Hsiao-Fei Lee, Jen-Hong Lan, Pei-Ju Chao, Hui-Min Ting, Hui-Chun Chen, Hsuan-Chih Hsu, Tsair-Fwu Lee
Background: Patients treated with radiotherapy are at risk of developing a second cancer during their lifetime, which can directly impact treatment decision-making and patient management. The aim of this study was to qualify and compare the secondary cancer risk (SCR) after intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in nasopharyngeal carcinoma (NPC) patients. Patients and methods: We analyzed the treatment plans of a cohort of 10 NPC patients originally treated with IMRT or VMAT...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#7
Barrett D Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole N Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
April 2018: Radiation Research
https://www.readbyqxmd.com/read/29344496/quadruple-neoplasms-following-radiation-therapy-for-congenital-bilateral-retinoblastoma
#8
Linda J Szymanski, Maria E Sibug Saber, Jonathan W Kim, John L Go, Gabriel Zada, Narsing Rao, Kyle M Hurth
Purpose: The aim of this study was to describe a 34-year-old male with hereditary bilateral retinoblastoma treated with radiotherapy as a child who developed 4 distinct tumors within the radiation field. Methods: A 34-year-old male with bilateral retinoblastoma status postradiation therapy and recurrence requiring enucleation presented with left-eye visual acuity changes. Magnetic resonance imaging demonstrated a left orbital mass and a right parasellar complex lobulated mass (right sphenoid and right cavernous sinus)...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29319640/orbital-extranodal-marginal-zone-lymphoma-following-radiotherapy-a-report-of-2-cases
#9
Zujaja Tauqeer, Frederick A Jakobiec, Suzanne K Freitag, Michael K Yoon, Natalie Wolkow
PURPOSE: To present 2 patients in whom orbital radiation preceded the development of periorbital extranodal marginal zone lymphoma by more than a decade and to investigate the likelihood of this representing irradiation-induced malignancy. METHODS: Retrospective chart review and histopathologic study with immunohistochemistry of 2 cases. RESULTS: The first patient was a 58-year-old woman who developed an orbital mass within the vicinity of the lateral rectus muscle 17 years after external beam proton radiation therapy for an inferotemporal choroidal melanoma...
January 9, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29106564/modelling-recurrence-and-second-cancer-risks-induced-by-proton-therapy
#10
V S K Manem, A Dhawan
In the past few years, proton therapy has taken the centre stage in treating various tumour types. The primary contribution of this study is to investigate the tumour control probability (TCP), relapse time and the corresponding secondary cancer risks induced by proton beam radiation therapy. We incorporate tumour relapse kinetics into the TCP framework and calculate the associated second cancer risks. To calculate proton therapy-induced secondary cancer induction, we used the well-known biologically motivated mathematical model, initiation-inactivation-proliferation formalism...
July 4, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29062118/propensity-score-matched-evaluation-of-the-incidence-of-radiation-pneumonitis-and-secondary-cancer-risk-for-breast-cancer-patients-treated-with-imrt-vmat
#11
Pei-Ju Chao, Hsiao-Fei Lee, Jen-Hong Lan, Shih-Sian Guo, Hui-Min Ting, Yu-Jie Huang, Hui-Chun Chen, Tsair-Fwu Lee
Propensity score matching evaluates the treatment incidence of radiation-induced pneumonitis (RP) and secondary cancer risk (SCR) after intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for breast cancer patients. Of 32 patients treated with IMRT and 58 who received VMAT were propensity matched in a 1:1 ratio. RP and SCR were evaluated as the endpoints of acute and chronic toxicity, respectively. Self-fitted normal tissue complication probability (NTCP) parameter values were used to analyze the risk of RP...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28946898/comparative-study-of-the-effects-of-different-radiation-qualities-on-normal-human-breast-cells
#12
Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda, Guido Hildebrandt
BACKGROUND: As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary malignant neoplasms might be significantly increased due to exposure of healthy tissue outside of the target field to secondary neutrons, in particular in proton therapy. Thus far, the radiobiological effects of these neutrons and a comparison with photons on normal breast cells have not been sufficiently characterised...
September 25, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28892775/challenges-and-perspectives-in-the-immunotherapy-of-hodgkin-lymphoma
#13
REVIEW
Jean-Marie Michot, Julien Lazarovici, David Ghez, Alina Danu, Christophe Fermé, Amélie Bigorgne, Vincent Ribrag, Aurélien Marabelle, Sandrine Aspeslagh
Hodgkin lymphoma (HL) was one of the first few cancers to be cured first with radiotherapy alone and then with a combination of chemotherapy and radiotherapy. Around 80% of the patients with HL will be cured by first-line therapy. However, the ionising radiation not only produces cytotoxicity but also induces alterations in the microenvironment, and patients often struggle with the long-term consequences of these treatments, such as cardiovascular disorders, lung diseases and secondary malignancies. Hence, it is essential to improve treatments while avoiding delayed side-effects...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28871993/predicted-rate-of-secondary-malignancies-following-adjuvant-proton-versus-photon-radiation-therapy-for-thymoma
#14
J Vogel, L Lin, L A Litzky, A T Berman, C B Simone
PURPOSE: Thymic malignancies are the most common tumors of the anterior mediastinum. The benefit of adjuvant radiation therapy for stage II disease remains controversial, and patients treated with adjuvant radiation therapy are at risk of late complications, including radiation-induced secondary malignant neoplasms (SMNs), that may reduce the overall benefit of treatment. We assess the risk of predicted SMNs following adjuvant proton radiation therapy compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28817446/bevacizumab-as-an-effective-treatment-for-radiation-necrosis-after-radiotherapy-for-melanoma-brain-metastases
#15
Isabella C Glitza, Nandita Guha-Thakurta, Neil M D'Souza, Rodabe N Amaria, Susan L McGovern, Ganesh Rao, Jing Li
Radiation necrosis (RN) is a potential late complication of radiotherapy for intracranial malignancy, which is often associated with significant neurological morbidity. Prolonged treatment with high-dose corticosteroids or surgical resection has been the standard care for RN, but protracted steroid use can lead to significant side effects and surgical resection is not always feasible. The antivascular endothelial growth factor monoclonal antibody bevacizumab induces clinical and radiographic improvements in RN, with overall good tolerance...
December 2017: Melanoma Research
https://www.readbyqxmd.com/read/28711224/the-radioprotector-ortho-phospho-l-tyrosine-ptyr-attenuates-the-side-effects-of-fractionated-irradiation-in-retinoblastoma-mouse-models-but-also-decreases-the-local-tumour-control
#16
Alexander V Tschulakow, Klaus Dittmann, Stephan M Huber, Dominik Klumpp, Benjamin Stegen, Ulrich Schraermeyer, H Peter Rodemann, Sylvie Julien-Schraermeyer
BACKGROUND: Radiotherapy (RT) is used to treat retinoblastoma (Rb), the most frequent ocular tumour in children. Besides eradicating the tumour, RT can cause severe side effects including secondary malignancies. This study aimed to define whether the radioprotector ortho-phospho-L-tyrosine (pTyr) prevents RT-induced side effects and affects local tumour control in a xenograft and a genetic orthotopic Rb mouse model. METHODS: B6;129-Rb1tm3Tyj/J (Rb+/- ) and Y79-Rb cell-xenografted nude mice were fractionated external beam irradiated (15 fractions of 5Gy 6MV photons during 3weeks) with or without pTyr pre-treatment (100mg/kg BW, 16h prior to each irradiation)...
September 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28707199/radiation-induced-inflammatory-cascade-and-its-reverberating-crosstalks-as-potential-cause-of-post-radiotherapy-second-malignancies
#17
REVIEW
Sonia Gandhi, Sudhir Chandna
The disease-free survival following radiotherapy is often limited by the development of second/secondary cancers. This significant impediment to effective cancer treatment implicated even in the modern-day radiotherapy needs to be countered effectively. Critical analysis reveals that besides achieving effective tumor control, radiotherapy elicits certain cellular and systemic inflammatory events in tumor infiltrate, which remain relatively stable and tend to facilitate "in-field" or "out of field" oncogenesis in due course of time...
June 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28706761/rapidly-fatal-radiation-induced-glioblastoma
#18
Ivy Ng, Char Loo Tan, Tseng Tsai Yeo, Balamurugan Vellayappan
Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agents, prior radiation exposure may play a role. We report on a patient who had been treated six years prior for a vestibular schwannoma with high-dose conventional radiotherapy and subsequently developed a rapidly fatal glioblastoma at the same location...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#19
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28602926/radiation-induced-malignant-peripheral-nerve-sheath-tumors-a-systematic-review
#20
REVIEW
Ryuya Yamanaka, Azusa Hayano
OBJECTIVE: Radiation-induced malignant peripheral nerve sheath tumors (MPNSTs) are an uncommon late risk of irradiation. We conducted the largest systematic review to date of individual patient data for patients with these tumors. METHODS: We conducted a systematic search using the PubMed database, and compiled a systematic literature review. We used Kaplan-Meier analysis and a log-rank test to estimate survival. RESULTS: We analyzed 65 radiation-induced and 26 radiation-associated MPNSTs in patients with neurofibromatosis...
September 2017: World Neurosurgery
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