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Radiation induced secondary malignancy

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https://www.readbyqxmd.com/read/28297433/secondary-cancer-incidence-risk-estimates-for-external-radiotherapy-and-high-dose-rate-brachytherapy-in-cervical-cancer-phantom-study
#1
Boram Lee, Sung Hwan Ahn, Hyeyoung Kim, Jaeman Son, Jiwon Sung, Youngyih Han, Seung Jae Huh, Jin Sung Kim, Dong Wook Kim, Myonggeun Yoon
This study was designed to estimate radiation-induced secondary cancer risks from high-dose-rate (HDR) brachytherapy and external radiotherapy for patients with cervical cancer based on measurements of doses absorbed by various organs. Organ doses from HDR brachytherapy and external radiotherapy were measured using glass rod dosimeters. Doses to out-of-field organs were measured at various locations inside an anthropomorphic phantom. Brachytherapy-associated organ doses were measured using a specialized phantom that enabled applicator insertion, with the pelvis portion of the existing anthropomorphic phantom replaced by this new phantom...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28279203/primary-burkitt-lymphoma-of-the-supraglottic-larynx-a-case-report-and-review-of-the-literature
#2
Alexandra E Quimby, Lisa Caulley, Danielle Rodin, Bibianna Purgina, Libni Eapen, Luke Shier, Stephanie Johnson-Obaseki
BACKGROUND: Burkitt lymphoma is a high-grade B cell lymphoma which accounts for less than 1% of all adult cases of non-Hodgkin lymphoma. Rare instances of Burkitt lymphoma developing secondary to prior irradiation have been described in the literature. CASE PRESENTATION: We report a case of a 90-year-old white woman with a recent history of irradiation for Hodgkin lymphoma, who presented with primary Burkitt lymphoma of the supraglottic larynx. She underwent emergency awake tracheostomy with biopsy...
March 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28274393/low-dose-cranial-boost-in-high-risk-adult-acute-lymphoblastic-leukemia-patients-undergoing-bone-marrow-transplant
#3
William Su, Marcher Thompson, Ren-Dih Sheu, Amir Steinberg, Luis Isola, Richard Stock, Richard L Bakst
PURPOSE: Acute lymphoblastic leukemia (ALL) has a predilection for CNS involvement. Patients with high-risk ALL are often managed with transplant using a radiation-based conditioning regimen. Historically, a high-dose prophylactic cranial boost (CB) of ≥12 Gy was given to reduce risk of central nervous system (CNS) recurrence. However, the use of CB has fallen out of favor because of toxicity concerns. In high-risk adults undergoing transplant at our institution, we have used a low-dose 6 Gy CB to reduce toxicity while conditioning adults with fully developed brains...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28203422/colobronchial-fistula-the-pathogenesis-clinical-presentations-diagnosis-and-treatment
#4
Jinbo Zhao, Nan Ma, Zhengwei Zhao, Jie Lei, Qiang Lu, Feng Tian, Yongan Zhou, Yong Han, Xiaofei Li
BACKGROUND: Colobronchial fistula (CBF) is rare and easy to be delayed in clinic. There is no systemic study about this disease. The pathogenesis, clinical presentations, diagnosis and treatment of CBF were analyzed in this study. METHODS: The clinical data from 37 cases of CBF, which included one case in our institute and the other 36 cases in literature from January 1960 to August 2016, were reviewed and analyzed. The etiology, clinical presentations, diagnostic and therapeutic methods, and outcomes were summarized...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28074770/-18f-fdg-pet-ct-contributes-to-diagnostics-and-therapy-monitoring-of-radiation-induced-angiosarcoma
#5
Francesca Cucchi, Jens Bülow, Lene Simonsen, Lotte Nedergaard, Christian Haarmark, Ali Asmar
Angiosarcomas are rare, aggressive malignant mesenchymal tumours with a poor prognosis. Radiation therapy is an independent risk factor for the development of secondary angiosarcoma. The onset of angiosarcoma may resemble benign lesions, leading to delayed diagnosis. It has been suggested that 18F-fluorodeoxyglucose (FDG) PET/CT scan may be useful in the early diagnosis in differentiating angiosarcoma from benign lesions and in therapy monitoring. We report the utility of 18F-FDG PET/CT scan in the diagnosis and follow-up of radiation-induced angiosarcoma in a patient previously treated for uterine cancer...
January 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28052027/estrogen-receptor-%C3%AE-ligation-inhibits-hodgkin-lymphoma-growth-by-inducing-autophagy
#6
Marina Pierdominici, Angela Maselli, Silvia L Locatelli, Laura Ciarlo, Giuseppa Careddu, Mario Patrizio, Barbara Ascione, Antonella Tinari, Carmelo Carlo-Stella, Walter Malorni, Paola Matarrese, Elena Ortona
Although Hodgkin lymphoma (HL) is curable with current therapy, at least 20% of patients relapse or fail to make complete remission. In addition, patients who achieve long-term disease-free survival frequently undergo infertility, secondary malignancies, and cardiac failure, which are related to chemotherapeutic agents and radiation therapies. Hence, new therapeutic strategies able to counteract the HL disease in this important patient population are still a matter of study. Estrogens, in particular 17β-estradiol (E2), have been suggested to play a role in lymphoma cell homeostasis by estrogen receptors (ER) β activation...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28003769/chronic-radiation-induced-dermatitis-challenges-and-solutions
#7
REVIEW
Mateusz Spałek
Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27989997/angiosarcoma-following-radiation-therapy-for-breast-cancer-case-report
#8
Konrad Wronski, Leszek Frackowiak
More and better accessibility to screening and increasing women's knowledge about the main symptomatic breast cancer signs result in detection of this neoplasm at an early stage, allowing a conservative surgical treatment. Breast conserving therapy (BCT) due to breast carcinoma involves the use of adjuvant radiotherapy which carries a risk the secondary radiation-induced malignancy. Angiosarcoma of the breast is an extremely rare radiation-induced malignant tumor following breast conserving therapy (BCT), first described by Schmidt in 1887...
December 20, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27959279/inhibition-of-cancer-cell-mitosis-by-reducing-the-availability-of-phosphate
#9
John Rhys Condon
The addition of phosphate groups is an essential requirement for the proper functioning of cyclin and cyclin dependent kinase which control various stages in the mitotic division of cancer cells. Thus limiting the availability of phosphate is likely to interfere with the metabolism of rapidly growing malignant cells. The human hormone glucagon and the anti metabolite mithramycin reduce serum phosphate by increasing phosphaturia and are both very effective in treating Paget's disease of bone, a precancerous condition...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27926660/radioembolization-induced-liver-disease-a-systematic-review
#10
Manon N G J A Braat, Karel J van Erpecum, Bernard A Zonnenberg, Maurice A J van den Bosch, Marnix G E H Lam
Radioembolization (RE) is a relatively novel treatment modality for primary and secondary hepatic malignancies. Microspheres embedded with a β-emitting radioisotope are injected into the hepatic artery, resulting in microsphere deposition in the tumor arterioles and normal portal triads. Microsphere deposition in nontumorous parenchyma can result in radiation-induced liver injury, with lethal RE-induced liver disease (REILD) at the outer end of the spectrum. The primary aim of this study was to evaluate RE-related hepatotoxicity and present an overview of the currently applied definitions and clinically relevant characteristics of REILD...
February 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27857781/delayed-hemorrhage-after-surgery-and-radiation-in-suprasellar-pilocytic-astrocytomas
#11
REVIEW
Mazda K Turel, Tim-Rasmus Kiehl, Fred Gentili
Delayed intracranial hemorrhage is a rare complication of treatment for central nervous system tumors. This may be secondary to malignant transformation of the tumor or vasculopathy related to radiation therapy (RT). While most reports on radiation-induced vasculopathy in children with optic pathway gliomas are associated with ischemic complications, there are only two reports of hemorrhagic complications in these patients. In both cases, the hemorrhage was asymptomatic and remote from the site of the original tumor but within the field of irradiation...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27816997/gamma-knife-radiosurgery-for-neurofibromatosis-type-2-associated-meningiomas-a-22-year-patient-series
#12
Brandon Birckhead, Terence T Sio, Bruce E Pollock, Michael J Link, Nadia N Laack
Neurofibromatosis type 2 (NF2) is a debilitating genetic condition with potential development of multiple meningiomas. We report our experience treating a series of NF2-associated intracranial meningiomas with Gamma Knife radiosurgery (GKRS). Between 1992 and 2013, 15 consecutive patients (age 20-54 years) with 62 intracranial meningiomas were treated with single-fraction GKRS. Fifty-five percent of tumors involved the convexity or parasagittal/falx. The median prescription dose was 16 Gy (range 13-20 Gy)...
November 5, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27785465/ureteroiliac-artery-fistula-caused-by-a-metallic-memokath-ureteral-stent-in-a-radiation-induced-ureteral-stricture
#13
Krishanu Das, Flavio Ordones, Sumudu Welikumbura, Nicholas R Brook
Background: Memokath 051™ stents are increasingly used for management of benign and malignant ureteral strictures refractory to management with single or tandem polymeric Double-J ureteral stents. Migration, encrustation, and difficulty in extraction during stent exchange are the chief problems reported so far with these thermoexpandable metallic stents. We report an unusual complication of ureteroexternal iliac artery fistula (UEAF) caused by Memokath stent inserted for radiation-induced ureteral stricture...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27764143/outcomes-in-critically-ill-patients-with-cancer-related-complications
#14
Viviane B L Torres, Juliana Vassalo, Ulysses V A Silva, Pedro Caruso, André P Torelly, Eliezer Silva, José M M Teles, Marcos Knibel, Ederlon Rezende, José J S Netto, Claudio Piras, Luciano C P Azevedo, Fernando A Bozza, Nelson Spector, Jorge I F Salluh, Marcio Soares
INTRODUCTION: Cancer patients are at risk for severe complications related to the underlying malignancy or its treatment and, therefore, usually require admission to intensive care units (ICU). Here, we evaluated the clinical characteristics and outcomes in this subgroup of patients. MATERIALS AND METHODS: Secondary analysis of two prospective cohorts of cancer patients admitted to ICUs. We used multivariable logistic regression to identify variables associated with hospital mortality...
2016: PloS One
https://www.readbyqxmd.com/read/27709409/radiation-induced-gliomas-a-comprehensive-review-and-meta-analysis
#15
REVIEW
Ryuya Yamanaka, Azusa Hayano, Tomohiko Kanayama
By conducting a systemic search of the PubMed database, we performed a comprehensive literature review to characterize secondary gliomas following radiotherapy treatment and to determine the most appropriate treatment strategy. Our analysis included 296 cases of radiation-induced gliomas. The primary lesion was characterized as a hematological malignancy in 104 cases (35.1 %), pituitary adenoma in 35 (11.8 %), craniopharyngioma in 19 (6.4 %), medulloblastoma in 38 (12.8 %), germ cell tumor in 13 (4.3 %), low-grade glioma in 28 (9...
October 5, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27685104/secondary-cancer-incidence-risk-estimates-for-external-radiotherapy-and-high-dose-rate-brachytherapy-in-cervical-cancer-phantom-study
#16
Boram Lee, Sung Hwan Ahn, Hyeyoung Kim, Jaeman Son, Jiwon Sung, Youngyih Han, Seung Jae Huh, Jin Sung Kim, Dong Wook Kim, Myonggeun Yoon
This study was designed to estimate radiation-induced secondary cancer risks from high-dose-rate (HDR) brachytherapy and external radiotherapy for patients with cervical cancer based on measurements of doses absorbed by various organs. Organ doses from HDR brachytherapy and external radiotherapy were measured using glass rod dosimeters. Doses to out-of-field organs were measured at various loca-tions inside an anthropomorphic phantom. Brachytherapy-associated organ doses were measured using a specialized phantom that enabled applicator insertion, with the pelvis portion of the existing anthropomorphic phantom replaced by this new phantom...
September 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27681222/stereotactic-radiation-therapy-for-hepatic-malignancies
#17
Jeffrey Meyer
Management of primary and secondary tumors of the liver is a complex undertaking involving multi‑disciplinary input. Radiation therapy has played a relatively marginal role in the treatment of liver tumors, but with technological innovations and the growth of the field of stereotactic body radiation therapy (SBRT), this role is evolving. In this review, I discuss the issues of radiation‑induced hepatic toxicity, the planning of liver SBRT treatments, clinical results with SBRT, its place amongst other non‑surgical ablative treatments, and potential future avenues of investigation...
December 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27663930/estimating-the-excess-lifetime-risk-of-radiation-induced-secondary-malignancy-smn-in-pediatric-patients-treated-with-craniospinal-irradiation-csi-conventional-radiation-therapy-versus-helical-intensity-modulated-radiation-therapy
#18
Jordan A Holmes, Bhishamjit S Chera, David J Brenner, Igor Shuryak, Adam K Wilson, Misty Lehman-Davis, David V Fried, Vivek Somasundaram, Jun Lian, Tim Cullip, Lawrence B Marks
PURPOSE: To quantify the risk of radiation-induced second malignancies (SMN) in pediatric patients receiving craniospinal irradiation (CSI) either with 3-dimensional conformal radiation therapy (Conv CSI) or tomotherapy helical intensity modulated radiation therapy (Tomo CSI). METHODS AND MATERIALS: A novel predictive model that accounts for short- and long-term carcinogenesis was incorporated into our institutional treatment planning system to quantify the lifetime risk of SMN in incidentally irradiated organs...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27601944/secondary-malignancy-following-radiotherapy-for-thyroid-eye-disease
#19
Christopher C Gillis, Eun Hae Chang, Khalid Al-Kharazi, Tom Pickles
AIM: To describe the first case of a secondary meningioma in a patient after radiation treatment for thyroid eye disease (TED). Secondarily to identify any additional cases of secondary malignancy resulting from radiotherapy for thyroid eye disease from our institutional experience. BACKGROUND: Thyroid eye disease (TED) is a self-limiting auto-immune disorder causing expansion of orbital soft tissue from deposition of glycosaminoglycans and collagen, leading to significant cosmetic and functional morbidity...
May 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27568562/mdm2-phosphorylation-regulates-its-stability-and-has-contrasting-effects-on-oncogene-and-radiation-induced-tumorigenesis
#20
Michael I Carr, Justine E Roderick, Hugh S Gannon, Michelle A Kelliher, Stephen N Jones
ATM phosphorylation of Mdm2-S394 is required for robust p53 stabilization and activation in DNA-damaged cells. We have now utilized Mdm2(S394A) knockin mice to determine that phosphorylation of Mdm2-S394 regulates p53 activity and the DNA damage response in lymphatic tissues in vivo by modulating Mdm2 stability. Mdm2-S394 phosphorylation delays lymphomagenesis in Eμ-myc transgenic mice, and preventing Mdm2-S394 phosphorylation obviates the need for p53 mutation in Myc-driven tumorigenesis. However, irradiated Mdm2(S394A) mice also have increased hematopoietic stem and progenitor cell functions, and we observed decreased lymphomagenesis in sub-lethally irradiated Mdm2(S394A) mice...
September 6, 2016: Cell Reports
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