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https://www.readbyqxmd.com/read/27906530/medicare-program-hospital-outpatient-prospective-payment-and-ambulatory-surgical-center-payment-systems-and-quality-reporting-programs-organ-procurement-organization-reporting-and-communication-transplant-outcome-measures-and-documentation-requirements-electronic
#1
(no author information available yet)
This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2017 to implement applicable statutory requirements and changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system...
November 14, 2016: Federal Register
https://www.readbyqxmd.com/read/27905941/financing-strategies-to-improve-essential-public-health-equalization-and-its-effects-in-china
#2
Li Yang, Li Sun, Liankui Wen, Huyang Zhang, Chenyang Li, Kara Hanson, Hai Fang
BACKGROUND: In 2009, China launched a health reform to promote the equalization of national essential public health services package (NEPHSP). The present study aimed to describe the financing strategies and mechanisms to improve access to public health for all, identify the strengths and weaknesses of the different approaches, and showed evidence on equity improvement among different regions. METHODS: We reviewed the relevant literatures and identified 208 articles after screening and quality assessment and conducted six key informants' interviews...
December 1, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27905658/-lymphocytic-colitis-in-a-patient-with-ulcerative-colitis-report-of-one-case
#3
Camila Estay, Daniela Simian, Lilian Flores, Antonio Piottante, Rodrigo Quera
The relationship between Microscopic Colitis and Inflammatory Bowel Disease is unclear. However, when both are diagnosed they seem to be part of a broader spectrum of the same disease, more than just a coincidence. We report a 55 years old woman with Ulcerative Colitis limited to the rectum with complete clinical and endoscopic response to standard treatment and adequate surveillance for 13 years, who abandoned treatment and control. After eight years, she consulted for mild-to-moderate non-bloody diarrhea lasting several months...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27905543/rapid-functional-cardiac-imaging-after-gadolinium-injection-evaluation-of-a-highly-accelerated-sequence-with-sparse-data-sampling-and-iterative-reconstruction
#4
Johannes Budjan, Holger Haubenreisser, Thomas Henzler, Sonja Sudarski, Michaela Schmidt, Christina Doesch, Ibrahim Akin, Martin Borggrefe, Nadja M Meßner, Stefan O Schoenberg, Ulrike I Attenberger, Theano Papavassiliu
To generate a patient-friendly, time-efficient cardiac MRI examination protocol, a highly accelerated real-time CINE MR sequence (SSIR) was acquired in the idle time in between contrast injection and late gadolinium enhancement phase. 20 consecutive patients underwent a cardiac MRI examination including a multi-breath-hold sequence as gold standard (Ref) as well as SSIR sequences with (SSIR-BH) and without breath-hold (SSIR-nonBH). SSIR sequences were acquired 4 minutes after gadolinium injection. Right- (RV) and left-ventricular (LV) volumetric functional parameters were evaluated and compared between Ref and SSIR sequences...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905522/circulating-cell-free-dna-telomere-length-and-bilirubin-in-the-vienna-active-ageing-study-exploratory-analysis-of-a-randomized-controlled-trial
#5
Anela Tosevska, Bernhard Franzke, Marlene Hofmann, Immina Vierheilig, Barbara Schober-Halper, Stefan Oesen, Oliver Neubauer, Barbara Wessner, Karl-Heinz Wagner
Telomere length (TL) in blood cells is widely used in human studies as a molecular marker of ageing. Circulating cell-free DNA (cfDNA) as well as unconjugated bilirubin (UCB) are dynamic blood constituents whose involvement in age-associated diseases is largely unexplored. To our knowledge, there are no published studies integrating all three parameters, especially in individuals of advanced age. Here we present a secondary analysis from the Vienna Active Aging Study (VAAS), a randomized controlled intervention trial in institutionalized elderly individuals (n = 101)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905482/pharmacologic-modulation-of-ror%C3%AE-t-translates-to-efficacy-in-preclinical-and-translational-models-of-psoriasis-and-inflammatory-arthritis
#6
Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Marciano Sablad, Natasha Rozenkrants, Jingxue Yu, Glenda Castro, Homayon Banie, Wai-Ping Fung-Leung, Luis Santamaria-Babi, Thomas Schlueter, Michael Albers, Kristi Leonard, Alison L Budelsky, Anne M Fourie
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required for Th17 differentiation and IL-17 production in adaptive and innate immune cells. We identified JNJ-54271074, a potent and highly-selective RORγt inverse agonist, which dose-dependently inhibited RORγt-driven transcription, decreased co-activator binding and promoted interaction with co-repressor protein...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905247/consultation-on-changes-to-technology-appraisals
#7
(no author information available yet)
A joint consultation by the National Institute for Health and Care Excellence (NICE) and NHS England sets out changes to the arrangements for evaluating and funding drugs, and for other health technologies appraised through NICE's relevant programmes. The aims of the consultation are to: » Give patients quicker access to the most cost-effective new treatments. » Offer more flexibility in the adoption of cost-effective, high-budget impact technologies in the NHS. » Provide greater clarity for patients and companies about when NICE-appraised treatments for rare conditions will automatically qualify for funding from routine commissioning budgets...
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27905241/-buddies-scheme-launched-to-develop-future-nurse-leaders
#8
Stephanie Jones-Berry
England's future chief nurses are being buddied with more senior nursing counterparts, as part of a new programme of succession planning from NHS Improvement (NHSI).
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27904964/only-walking-matters-assessment-following-lumbar-stenosis-decompression
#9
S Budithi, Rohit Dhawan, Andrew Cattell, Birender Balain, David Jaffray
PURPOSE: Multiple outcome measures exist to evaluate the outcomes of spinal decompression surgery; however, these tend to be complex and are difficult to express to the patient pre-operatively to accurately guide their expectations. We present outcomes, in terms of walking distance measurement, of a prospective single surgeon series of 76 consecutive patients with spinal stenosis. METHODS: 76 patients (mean age 68.8 years; 48-91 years) had decompression surgery using spinous process osteotomy...
November 30, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27903970/ion-channels-in-control-of-pancreatic-stellate-cell-migration
#10
Hannah Storck, Benedikt Hild, Sandra Schimmelpfennig, Sarah Sargin, Nikolaj Nielsen, Angela Zaccagnino, Thomas Budde, Ivana Novak, Holger Kalthoff, Albrecht Schwab
Pancreatic stellate cells (PSCs) play a critical role in the progression of pancreatic ductal adenocarcinoma (PDAC). Once activated, PSCs support proliferation and metastasis of carcinoma cells. PSCs even co-metastasise with carcinoma cells. This requires the ability of PSCs to migrate. In recent years, it has been established that almost all "hallmarks of cancer" such as proliferation or migration/invasion also rely on the expression and function of ion channels. So far, there is only very limited information about the function of ion channels in PSCs...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903932/laparoscopic-approach-to-splenic-aneurysms
#11
Piotr Małczak, Michał Wysocki, Piotr Major, Michał Pędziwiatr, Anna Lasek, Tomasz Stefura, Dorota Radkowiak, Anna Zub-Pokrowiecka, Andrzej Budzyński
BACKGROUND: Splenic artery aneurysm is a rare disease with possibly mortal complications. For years, the main method of treatment was excision of aneurysm with spleen. In recent years, several methods have been developed in order to salvage the spleen such endovascular techniques and aneurysmectomy. OBJECTIVE: The aim of our study was to determine the feasibility of laparoscopic aneurysmectomy with spleen salvage in cases of splenic artery aneurysm. MATERIALS: Analysis of prospectively gathered data containing records of patients operated laparoscopically due to diseases of the spleen in 1998-2016 in our department...
November 30, 2016: Vascular
https://www.readbyqxmd.com/read/27903914/proteomic-analysis-of-the-human-keops-complex-identifies-c14orf142-as-a-core-subunit-homologous-to-yeast-gon7
#12
Leo C K Wan, Pierre Maisonneuve, Rachel K Szilard, Jean-Philippe Lambert, Timothy F Ng, Noah Manczyk, Hao Huang, Rob Laister, Amy A Caudy, Anne-Claude Gingras, Daniel Durocher, Frank Sicheri
The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N(6)-threonylcarbamoyladenosine (t(6)A), a universally conserved tRNA modification found on ANN-codon recognizing tRNAs. In archaea and eukaryotes, KEOPS is composed of OSGEP/Kae1, PRPK/Bud32, TPRKB/Cgi121 and LAGE3/Pcc1. In fungi, KEOPS contains an additional subunit, Gon7, whose orthologs outside of fungi, if existent, remain unidentified. In addition to displaying defective t(6)A biosynthesis, Saccharomyces cerevisiae strains harboring KEOPS mutations are compromised for telomere homeostasis, growth and transcriptional co-activation...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903605/a-dividing-matter-drp1-dnm1-independent-mitophagy
#13
Martin Graef
Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial. In this issue, Yamashita et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605093) report that mitochondrial fragments start to bud and divide from mitochondrial tubules when in tight association with forming autophagosomes, but independently of the mitochondrial division factor Drp1/Dnm1.
November 30, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27903558/cost-effectiveness-analysis-of-routine-pneumococcal-vaccination-in-the-uk-a-comparison-of-the-phid-cv-vaccine-and-the-pcv-13-vaccine-using-a-markov-model
#14
Emmanuelle Delgleize, Oscar Leeuwenkamp, Eleni Theodorou, Nicolas Van de Velde
OBJECTIVES: In 2010, the 13-valent pneumococcal conjugate vaccine (PCV-13) replaced the 7-valent vaccine (introduced in 2006) for vaccination against invasive pneumococcal diseases (IPDs), pneumonia and acute otitis media (AOM) in the UK. Using recent evidence on the impact of PCVs and epidemiological changes in the UK, we performed a cost-effectiveness analysis (CEA) to compare the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with PCV-13 in the ongoing national vaccination programme...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27903254/mir-96-mir-145-and-mir-9-expression-increases-and-igf-1r-and-foxo1-expression-decreases-in-peripheral-blood-mononuclear-cells-of-aging-humans
#15
Monika Budzinska, Magdalena Owczarz, Eliza Pawlik-Pachucka, Malgorzata Roszkowska-Gancarz, Przemyslaw Slusarczyk, Monika Puzianowska-Kuznicka
BACKGROUND: In mammals, the IGF-1 pathway affects the phenotype of aging. Since the function of the immune system is modulated by IGF-1, it is plausible that immunosenescence might in part result from altered control by this pathway. We therefore examined whether the expression of IGF-1R, FOXO1, and FOXO3a in peripheral blood mononuclear cells (PBMC) changes with age and if this might be due to changes in the expression of select miRNAs. METHODS: The expression of IGF-1R, FOXO1, FOXO3a, as well as of miR-9, miR-96, miR-99a, miR-132, miR-145, and miR-182 was examined in PBMC of young (27...
November 30, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27902593/angiosarcoma-in-the-chest-radiologic-pathologic-correlation-case-report
#16
Sara Piciucchi, Alessandra Dubini, Sara Tomassetti, Stefano Sanna, Claudia Ravaglia, Angelo Carloni, Christian Gurioli, Carlo Gurioli, Thomas V Colby, Venerino Poletti
RATIONALE: Angiosarcomas are rare, malignant vascular tumors. PATIENT CONCERNS: They represents about 2% of all soft tissue sarcoma, which can often metastasize through the hematogenous route. The radiological features have been analyzed in 4 patients with metastatic angiosarcoma in the chest. DIAGNOSES: The main radiologic findings included nodules, cysts, nodules with halo sign, and vascular tree-in-bud. Morphologic features, as observed in the histologic specimen, have been correlated with radiologic appearance...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27902442/the-whcd-gene-of-corynebacterium-glutamicum-plays-roles-in-cell-division-and-envelope-formation
#17
Dong-Seok Lee, Younhee Kim, Heung-Shick Lee
In this study, we analyzed the whcD gene from Corynebacterium glutamicum, which encodes a homolog of whiB, a Streptomyces coelicolor gene required for the sporulation of aerial hyphae. Deletion of the gene (ΔwhcD) severely affected cell growth in C. glutamicum. The ΔwhcD strain exhibited a large, filamentous, branched, and bud-shaped morphology with multiple septa. The transcription levels of the cell division genes involved in Z-ring assembly and septal peptidoglycan synthesis, including ftsZ, sepF, ftsQ, and ftsI, were markedly decreased in the ΔwhcD strain...
November 24, 2016: Microbiology
https://www.readbyqxmd.com/read/27902406/mlvf-as-a-method-for-rapid-and-cost-effective-typing-of-animal-associated-staphylococcus-aureus-strains-from-lineages-other-than-st398
#18
Maja Kosecka-Strojek, Weronika M Ilczyszyn, Aneta Buda, Klaudia Polakowska, Krzysztof Murzyn, Tomasz Panz, Anna Bialecka, Andrzej Kasprowicz, Antoni Jakubczak, Jaroslaw Krol, Alina Wieliczko, Benedykt Wladyka, Jacek Miedzobrodzki
In veterinary medicine, Staphylococcus aureus is associated with a range of mild to severe infections. The high density of livestock in intensive farming systems increases the risk of disease spread and hampers its control and measures of prevention, making S. aureus one of the most important animal pathogens. Multiple-locus VNTR fingerprinting (MLVF) has been successfully applied to the characterization of livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) ST398 but not to the characterization of a wide range of other animal isolates...
October 25, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902274/pleomorphochaeta-caudata-gen-nov-sp-nov-an-anaerobic-bacterium-isolated-from-an-offshore-oil-well-reclassification-of-sphaerochaeta-multiformis-mo-spc2t-as-pleomorphochaeta-multiformis-mo-spc2t-comb-nov-as-the-type-strain-of-this-new-genus-and-emended-description
#19
Boussad Arroua, Anthony Ranchou-Peyruse, Magali Ranchou-Peyruse, Michel Magot, Laurent Urios, Regis Grimaud
A strictly anaerobic Gram-negative bacterium, designated strain SEBR 4223T, was isolated from the production water of an offshore Congolese oil field. Cells were non-motile, pleomorphic and having spherical, annular or budding shapes and often exhibiting long stalks. Strain SEBR 4223T grew on a range of carbohydrates, optimally at 37°C and pH 7, in a medium containing 40 g.l-1 NaCl. Predominant fatty acids were C14:0, C14:0 DMA, C16:0 and C16:1ω7c and the major polar lipids were phosphoglycolipids (PGL), phospholipids (PL), glycolipids (GL) and diphosphatidylglycerol (DPG)...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902209/fimbriiglobus-ruber-gen-nov-sp-nov-a-gemmata-like-planctomycete-from-sphagnum-peat-bog-and-the-proposal-of-gemmataceae-fam-nov
#20
Irina S Kulichevskaya, Anastasia A Ivanova, Olga I Baulina, W Irene C Rijpstra, Jaap S Sinninghe Damsté, Svetlana N Dedysh
An aerobic, budding, dark pink to red-pigmented bacterium was isolated from an acidic boreal Sphagnum peat bog and designated strain SP5T. Cells of this strain were non-motile spheres that were uniformly covered with crateriform pits and fimbria, and tended to form aggregates during growth in liquid media. Strain SP5T was capable of growth at pH values between 4.0 and 6.8 (optimum at pH 5.5-6.0) and at temperatures between 10 and 30oC (optimum 20-25oC). The preferred growth substrates were sugars and some heteropolysaccharides...
October 24, 2016: International Journal of Systematic and Evolutionary Microbiology
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