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https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#1
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926776/the-impact-of-price-policy-on-demand-for-alcohol-in-rural-india
#2
Arjunan Subramanian, Parmod Kumar
Whether raising the price of addictive goods can reduce its burden is widely debated in many countries, largely due to lack of appropriate data and robust methods. Three key concerns frequently raised in the literature are: unobserved heterogeneity; omitted variables; identification problem. Addressing these concerns, using robust instrument and employing unique individual-level panel data from Indian Punjab, this paper investigates two related propositions (i) will increase in alcohol price reduce its burden (ii) since greater incomes raise the costs of inebriation, will higher incomes affect consumption of alcohol negatively...
August 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926752/response-bias-and-response-monitoring-evidence-from-healthy-older-adults-and-patients-with-mild-alzheimer-s-disease
#3
Rebecca G Deason, Michelle J Tat, Sean Flannery, Prabhakar S Mithal, Erin P Hussey, Eileen T Crehan, Brandon A Ally, Andrew E Budson
Patients with Alzheimer's disease (AD) often exhibit an abnormally liberal response bias in recognition memory tests, responding "old" more frequently than "new." Investigations have shown patients can to shift to a more conservative response bias when given instructions. We examined if patients with mild AD could alter their response patterns when the ratio of old items is manipulated without explicit instruction. Healthy older adults and AD patients studied lists of words and then were tested in three old/new ratio conditions (30%, 50%, or 70% old items)...
September 16, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28926609/developmental-expression-of-membrane-type-4-matrix-metalloproteinase-mt4-mmp-mmp17-in-the-mouse-embryo
#4
María José Blanco, Iván Rodríguez-Martín, Ana I R Learte, Cristina Clemente, María Gregoria Montalvo, Motoharu Seiki, Alicia G Arroyo, Cristina Sánchez-Camacho
Matrix metalloproteinases (MMPs) constitute a large group of endoproteases that play important functions during embryonic development, tumor metastasis and angiogenesis by degrading components of the extracellular matrix. Within this family, we focused our study on Mt4-mmp (also called Mmp17) that belongs to a distinct subset that is anchored to the cell surface via a glycosylphosphatidylinositol (GPI) moiety and with the catalytic site exposed to the extracellular space. Information about its function and substrates is very limited to date, and little has been reported on its role in the developing embryo...
2017: PloS One
https://www.readbyqxmd.com/read/28926598/-if-he-could-speak-he-would-be-able-to-point-out-who-does-those-things-to-him-experiences-of-violence-and-access-to-child-protection-among-children-with-disabilities-in-uganda-and-malawi
#5
Lena Morgon Banks, Susan A Kelly, Nambusi Kyegombe, Hannah Kuper, Karen Devries
INTRODUCTION: There is growing evidence that children with disabilities face an increased risk of violence globally. While child protection mechanisms to prevent and respond to violence-including formal government systems and more informal programmes and activities run by local communities or NGOs-are slowly becoming operationalised in low- and- middle-income countries, little is known about whether existing mechanisms are disability-inclusive. The aim of this study is to provide a better understanding of children with disabilities' experiences of violence and their access to available child protection mechanisms in low resource settings...
2017: PloS One
https://www.readbyqxmd.com/read/28926592/polish-physicians-cooperation-with-the-pharmaceutical-industry-and-its-potential-impact-on-public-health
#6
Marta Makowska
OBJECTIVE: This article aims to describe how Polish physicians cooperate with the pharmaceutical industry and show how this relationship may pose a threat to public health. METHODS: It considers the results of an online survey of 379 physicians. The survey was hosted by surveymonkey.com with links from a Polish physicians' website (Medycyna Praktyczna) between 29 October 2013 and 31 December 2013. The sample was purposive, respondents having to be physicians working in Poland...
2017: PloS One
https://www.readbyqxmd.com/read/28926344/the-effect-of-severity-of-illness-on-spine-surgery-costs-across-new-york-state-hospitals-an-analysis-of-69-831-cases
#7
I David Kaye, Murillo Adrados, Raj J Karia, Themistocles S Protopsaltis, Joseph A Bosco
STUDY DESIGN: Observational database review. OBJECTIVE: To determine the effect of patient severity of illness (SOI) on the cost of spine surgery among New York state hospitals. SUMMARY OF BACKGROUND DATA: National health care spending has risen at an unsustainable rate with musculoskeletal care, and spine surgery in particular, accounting for a significant portion of this expenditure. In an effort towards cost-containment, health care payers are exploring novel payment models some of which reward cost savings but penalize excessive spending...
September 18, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28926086/common-variants-in-dlg1-locus-are-associated-with-non-syndromic-cleft-lip-with-or-without-cleft-palate
#8
Adrianna Mostowska, Agnieszka Gaczkowska, Kacper Żukowski, Kerstin U Ludwig, Kamil K Hozyasz, Piotr Wójcicki, Elizabeth Mangold, Anne C Böhmer, Stefanie Heilmann-Heimbach, Michael Knapp, Małgorzata Zadurska, Barbara Biedziak, Margareta Budner, Agnieszka Lasota, Agata Daktera-Micker, Paweł P Jagodziński
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common craniofacial anomaly with a complex and heterogeneous etiology. Knowledge regarding specific genetic factors underlying this birth defect is still not well understood. Therefore, we conducted an independent replication analysis for the top-associated variants located within the DLG1 locus at chromosome 3q29, which was identified as a novel cleft-susceptibility locus in our genome-wide association study (GWAS). Mega-analysis of the pooled individual data from the GWAS and replication study confirmed that common DLG1 variants are associated with the risk of nsCL/P...
September 19, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28926010/economic-assessment-of-an-emerging-disease-the-case-of-schmallenberg-virus-in-france
#9
A Waret-Szkuta, P Alarcon, B Hasler, J Rushton, F Corbière, D Raboisson
Schmallenberg virus (SBV) was first detected in 2011 in Germany and then in France in 2012. This study simulates the production of different ruminant systems in France and estimates, through partial budget analyses, the economic cost of SBV at the farm level, under two disease scenarios (a high-impact and low-impact scenario). A partial budget is used to evaluate the financial effect of incremental changes, and includes only resources or production that will be changed. In the high-impact scenario, the estimated impact of SBV ranged from €23 to €43 per cow per year and €19 to €37 per ewe per year...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925705/incoherent-pathways-of-charge-separation-in-organic-hybrid-solar-cells
#10
Alexander Grupp, Philipp Ehrenreich, Julian Kalb, Arne Budweg, Lukas Schmidt-Mende, Daniele Brida
In this work, we investigate the exciton dissociation dynamics occurring at the donor-acceptor interface in organic and hybrid blends employed in the realization of photovoltaic cells. Fundamental differences in the charge separation process are studied with the organic semiconductor polymer poly(3-hexylthiophene) (P3HT) and either [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) or titanium dioxide (TiO2) acting as acceptor. By using ultrafast broadband transient absorption spectroscopy with few-fs temporal resolution, we observe that in both cases the incoherent formation of free charges is dominating the charge generation process...
September 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28925545/methane-delays-the-senescence-and-browning-in-daylily-buds-by-re-established-redox-homeostasis
#11
Huali Hu, Dan Liu, Pengxia Li
BACKGROUND: During the postharvest senescence of fruits and vegetables, redox imbalance occurs. Although the release of methane (CH4 ) has been observed for a long time and its antioxidant properties have recently been demonstrated in animals and plants, the corresponding physiological role of CH4 in regulating plant senescence has not yet been elucidated. RESULTS: Here, our results indicate that the postharvest deterioration of daylily buds during storage is greatly ameliorated by the exogenous application of CH4 , particularly in the inhibition of tissue browning...
September 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28924627/structure-and-biogenesis-of-ribonucleoprotein-bodies-in-epidermal-cells-of-caragana-arborescens-l
#12
Elizabeth Kordyum, Ninel Bilyavska
Epidermal cells of leaf petioles, pedicles, and sepals in Caragana arborescens L. are characterized with a unique biogenesis of intracellular bodies, the presence of which continues during 10-12 days in spring, from budding till flowering and fruit inception. Initially, a nuclear body is formed as a derivative of the nucleolus at the beginning of elongation of the protodermal cells, whereas a cytoplasmic body is formed in the proximity of the nuclear envelope later. Nuclear bodies and cytoplasmic bodies do not contain DNA, lipids, and starch, and they consist of RNA tightly packaged with proteins mainly in the form of short thin fibrils with thickness of 6 nm...
September 19, 2017: Protoplasma
https://www.readbyqxmd.com/read/28924351/moving-on-from-representativeness-testing-the-utility-of-the-global-drug-survey
#13
Monica J Barratt, Jason A Ferris, Renee Zahnow, Joseph J Palamar, Larissa J Maier, Adam R Winstock
A decline in response rates in traditional household surveys, combined with increased internet coverage and decreased research budgets, has resulted in increased attractiveness of web survey research designs based on purposive and voluntary opt-in sampling strategies. In the study of hidden or stigmatised behaviours, such as cannabis use, web survey methods are increasingly common. However, opt-in web surveys are often heavily criticised due to their lack of sampling frame and unknown representativeness. In this article, we outline the current state of the debate about the relevance of pursuing representativeness, the state of probability sampling methods, and the utility of non-probability, web survey methods especially for accessing hidden or minority populations...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28924205/the-multifunctional-polydnavirus-tnbvank1-protein-impact-on-host-apoptotic-pathway
#14
Rosanna Salvia, Gerarda Grossi, Angela Amoresano, Carmen Scieuzo, Marisa Nardiello, Chiara Giangrande, Ilaria Laurenzana, Vitalba Ruggieri, Sabino A Bufo, S Bradleigh Vinson, Monica Carmosino, David Neunemann, Heiko Vogel, Pietro Pucci, Patrizia Falabella
Toxoneuron nigriceps (Hymenoptera, Braconidae) is an endophagous parasitoid of the larval stages of the tobacco budworm, Heliothis virescens (Lepidoptera, Noctuidae). The bracovirus associated with this wasp (TnBV) is currently being studied. Several genes expressed in parasitised host larvae have been isolated and their possible roles partly elucidated. TnBVank1 encodes an ankyrin motif protein similar to insect and mammalian IκB, an inhibitor of the transcription nuclear factor κB (NF-κB). Here we show that, when TnBVank1 was stably expressed in polyclonal Drosophila S2 cells, apoptosis is induced...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924051/the-stress-regulatory-transcription-factors-msn2-and-msn4-regulate-fatty-acid-oxidation-in-budding-yeast
#15
Praveen Kumar Rajvanshi, Madhuri Arya, Ram Rajasekharan
The transcription factors multicopy suppressor of SNF1 mutation (Msn) Msn2 and Msn4 bind the stress-response element in gene promoters in the yeast Saccharomyces cerevisiae. However, the roles of Msn2/4 in primary metabolic pathways such as fatty acid β-oxidation are unclear. Here, in silico analysis revealed that the promoters of most genes involved in the biogenesis, function, and regulation of the peroxisome contain Msn2/4 binding sites. We also found that transcript levels of MSN2/MSN4 are increased in glucose-depletion conditions and that during growth in nonpreferred carbon sources, Msn2 is constantly localized to the nucleus in wildtype cells...
September 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28923796/rebound-adrenal-insufficiency-after-withdrawal-of-ritonavir-in-a-65-year-old-man-using-inhaled-budesonide
#16
Olivier Veilleux, Todd C Lee, Emily G McDonald
No abstract text is available yet for this article.
September 18, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28923635/living-donor-liver-transplantation-for-budd-chiari-syndrome-case%C3%A2-series
#17
C Karaca, C Yilmaz, R Ferecov, Z Iakobadze, K Kilic, L Caglayan, S Aydogdu, M Kilic
BACKGROUND: Venous reconstruction in living-donor liver transplantation for Budd-Chiari syndrome (BCS) has challenges because the grafts from living donors lack vena cava, and hepatic venous anastomosis must be performed on an already-thrombosed and/or stenosed inferior vena cava. Several techniques are described to overcome this problem, and we represent our experience with 22 patients. METHODS: Medical recordings of 22 patients were retrospectively collected, and disease-specific data as well as recordings about surgical technique were analyzed...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923621/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-related-urinary-tract-infection-in-kidney-transplant-recipients-risk-factors-treatment-and-long-term-outcome
#18
S Brakemeier, S I Taxeidi, B Zukunft, D Schmidt, J Gaedeke, M Dürr, S Hansen, K Budde
BACKGROUND: Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has risen in kidney transplant (KT) patients, with no long-term data so far on graft function or survival. METHODS: KT patients with ESBL-E-positive urine culture were retrospectively analyzed regarding initial adequate antimicrobial therapy, recurrent infection, transplant function, and survival compared with an ESBL-E-negative KT control cohort. RESULTS: ESBL-E-positive KT patients (n = 93) were older (55...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923620/late-conversion-to-belatacept-after-kidney-transplantation-outcome-and-prognostic-factors
#19
M Dürr, N Lachmann, B Zukunft, D Schmidt, K Budde, S Brakemeier
BACKGROUND: Conversion to belatacept at a later point after kidney transplantation (KT) as a rescue therapy has been shown to be beneficiary in an increasing number of patients, but prognostic factors for a favorable outcome have never been investigated. METHODS: The present study analyzed all KT patients after late conversion to belatacept in a single center regarding graft survival and changes in estimated glomerular filtration rate (eGFR), proteinuria, and mean fluorescence intensity (MFI) of donor-specific antibodies (DSA)...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923574/a-systematic-review-of-health-economic-evaluation-in-adjuvant-breast-radiotherapy-quality-counted-by-numbers
#20
Chris Monten, Liv Veldeman, Nick Verhaeghe, Yolande Lievens
BACKGROUND: Evolving practice in adjuvant breast radiotherapy inevitably impacts healthcare budgets. This is reflected in a rise of health economic evaluations (HEE) in this domain. The available HEE literature was analysed qualitatively and quantitatively, using available instruments. METHODS: HEEs published between 1/1/2000 and 31/10/2016 were retrieved through a systematic search in Medline, Cochrane and Embase. A quality-assessment using CHEERS (Consolidated Health Economic Evaluation Reporting Standards) was translated into a quantitative score and compared with Tufts Medical Centre CEA registry and Quality of Health Economic Studies (QHES) results...
September 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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