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Diabetes, ckd, esrd and trial

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https://www.readbyqxmd.com/read/27753805/ssa-02-4-disparities-in-hypertension-management-of-ckd-in-south-asia
#1
Tazeen Jafar
Chronic kidney disease (CKD) defined as reduced estimated glomerular filtration rate (eGFR) or presence of albuminuria, progresses to end stage renal disease (ESRD), needing dialysis or kidney transplant to sustain life, and is associated with increased risks of premature cardiovascular disease (CVD) and mortality. CKD ranked 18 leading (and most rapidly rising cause of mortality by the Global Burden of Disease Study 2010. The social and economic consequences of CKD are far worse in low and middle income countries (LMICs) including India, Pakistan, Bangladesh, and Sri Lanka...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27646425/c-reactive-protein-and-risk-of-esrd-results-from-the-trial-to-reduce-cardiovascular-events-with-aranesp-therapy-treat
#2
Finnian R Mc Causland, Brian Claggett, Emmanuel A Burdmann, Kai-Uwe Eckardt, Reshma Kewalramani, Andrew S Levey, John J V McMurray, Patrick Parfrey, Giuseppe Remuzzi, Ajay K Singh, Scott D Solomon, Robert D Toto, Marc A Pfeffer
BACKGROUND: To better understand a potential association of elevated C-reactive protein (CRP) level with progression of chronic kidney disease (CKD), we examined the relationship of CRP level with the development of end-stage renal disease (ESRD) in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). STUDY DESIGN: Post hoc analysis of a randomized controlled trial. SETTING & PARTICIPANTS: 4,038 patients with type 2 diabetes, CKD, and anemia in TREAT...
December 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27642932/ssa-02-4-disparities-in-hypertension-management-of-ckd-in-south-asia
#3
Tazeen Jafar
Chronic kidney disease (CKD) defined as reduced estimated glomerular filtration rate (eGFR) or presence of albuminuria, progresses to end stage renal disease (ESRD), needing dialysis or kidney transplant to sustain life, and is associated with increased risks of premature cardiovascular disease (CVD) and mortality. CKD ranked 18 leading (and most rapidly rising cause of mortality by the Global Burden of Disease Study 2010. The social and economic consequences of CKD are far worse in low and middle income countries (LMICs) including India, Pakistan, Bangladesh, and Sri Lanka...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27583237/the-effect-of-renin-angiotensin-system-inhibitors-on-kidney-allograft-survival-a-systematic-review-and-meta-analysis
#4
Wisit Cheungpasitporn, Charat Thongprayoon, Michael A Mao, Wonngarm Kittanamongkolchai, Insara J J Sathick, Stephen B Erickson
BACKGROUND: The use of renin-angiotensin system (RAS) inhibitors in patients with chronic kidney disease, and especially in diabetic kidney disease, has been shown to provide renoprotective effects and slow progression to end-stage renal disease. However, this protective effect in kidney transplant patient populations is unclear. AIM: The objective of this systematic review and meta-analysis was to evaluate the effect of RAS inhibitors on kidney allograft survival...
July 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27532796/multidisciplinary-management-of-diabetic-kidney-disease-a-systematic-review-and-meta-analysis
#5
Nancy Helou, Andrew Dwyer, Maya Shaha, Anne Zanchi
BACKGROUND: The increasing prevalence of diabetes poses significant challenges to healthcare systems around the world. Diabetes is the leading cause of end-stage renal disease. Diabetic kidney disease (DKD) is becoming a global health concern because it is a progressive disease associated with major health complications and increased health costs. The treatment goals for DKD are to slow the progression of the renal disease and prevent cardiovascular events. Accordingly, patients are expected to adhere to prescribed treatments and manage a wide range of daily self-care activities...
July 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27528374/safety-and-efficacy-of-incretin-based-therapies-in-patients-with%C3%A2-type-2-diabetes-mellitus-and-ckd-a-systematic-review%C3%A2-and-meta-analysis
#6
Patricia M Howse, Lyudmila N Chibrikova, Laurie K Twells, Brendan J Barrett, John-Michael Gamble
BACKGROUND: The pharmacokinetics and pharmacodynamics of antidiabetic therapies for patients with type 2 diabetes are often altered in the context of chronic kidney disease (CKD). STUDY DESIGN: Systematic review and meta-analysis. SETTING & POPULATION: Patients with type 2 diabetes and CKD. SELECTION CRITERIA FOR STUDIES: 2 reviewers independently screened studies identified through bibliographic databases (Cochrane Library, PubMed, Embase, International Pharmaceutical Abstracts), clinical trial registries, and references from pertinent articles and clinical practice guidelines...
August 12, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27492324/modulation-of-endogenous-antioxidant-defense-and-the-progression-of-kidney-disease-in-multi-heritage-groups-of-patients-with-type-2-diabetes-prospective-evaluation-of-early-nephropathy-and-its-treatment-prevent
#7
Kenneth A Earle, Karima Zitouni, John Pepe, Maria Karaflou, James Godbold
BACKGROUND: Diabetes is the western world's leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabetes, can be prevented by anti-oxidative treatment. Patients of non-Caucasian heritage have low activity of the selenoprotein, antioxidant enzyme, glutathione peroxidase (GPx) and its co-factor vitamin E, which may be linked to their increased propensity to developing end-stage renal disease...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27436163/a-systematic-review-of-the-benefits-and-harms-of-dipeptidyl-peptidase-4-inhibitor-for-chronic-kidney-disease
#8
Hiroyuki Kamiya
Introduction Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD) and the optimal glycemic control is key to delay the progression of the disease and prevent major complications. Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as a promising therapeutic option. However, the benefits and harms of the treatment have yet to be clarified for diabetic patients with CKD. Methods Type 2 diabetic patients with moderate to severe CKD including end-stage renal disease were eligible and randomized controlled trials comparing DPP-4 inhibitors with no treatment or placebo or other antihyperglycemic agents were included...
July 19, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27354825/doubling-of-serum-creatinine-and-the-risk-of-cardiovascular-outcomes-in-patients-with-chronic-kidney-disease-and-type-2-diabetes-mellitus-a-cohort-study
#9
Cornelia Schneider, Blai Coll, Susan S Jick, Christoph R Meier
BACKGROUND: Doubling of serum creatinine is often used as a marker for worsening kidney function in nephrology trials. Most people with chronic kidney disease die of other causes before reaching end-stage renal disease. We were interested in the association between doubling of serum creatinine and the risk of a first-time diagnosis of angina pectoris, congestive heart failure (CHF), myocardial infarction (MI), stroke, or transient ischemic attack in patients with chronic kidney disease and with diagnosed type 2 diabetes mellitus...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27340676/silymarin-in-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Luminita Voroneanu, Ionut Nistor, Raluca Dumea, Mugurel Apetrii, Adrian Covic
Type 2 diabetes mellitus (T2DM) is associated with increased risk of cardiovascular disease and nephropathy-now the leading cause of end-stage renal disease and dialysis in Europe and the United States. Inflammation and oxidative stress play a pivotal role in the development of diabetic complications. Silymarin, an herbal drug with antioxidant and anti-inflammatory properties, may improve glycemic control and prevent the progression of the complications. In a systematic review and meta-analysis including five randomized controlled trials and 270 patients, routine silymarin administration determines a significant reduction in fasting blood glucose levels (-26...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27312437/intensive-glycemic-control-and-the-risk-of-end-stage-renal-disease-an-advance-in-the-management-of-diabetes
#11
Christina M Wyatt, Daniel C Cattran
Posttrial follow-up of participants randomized to intensive versus standard glycemic control in the ADVANCE trial has demonstrated a significant benefit of intensive glycemic control on the risk of end-stage renal disease. In a more detailed analysis, intensive glycemic control appears to be of benefit only before the development of clinically evident kidney disease or in patients with documented early-stage chronic kidney disease.
July 2016: Kidney International
https://www.readbyqxmd.com/read/27225988/effects-of-stenting-for-atherosclerotic-renal-artery-stenosis-on-egfr-and-predictors-of-clinical-events-in-the-coral-trial
#12
Katherine R Tuttle, Lance D Dworkin, William Henrich, Barbara A Greco, Michael Steffes, Sheldon Tobe, Joseph I Shapiro, Kenneth Jamerson, Asya Lyass, Karol Pencina, Joseph M Massaro, Ralph B D'Agostino, Donald E Cutlip, Timothy P Murphy, Christopher J Cooper
BACKGROUND AND OBJECTIVES: Atherosclerotic renal artery stenosis may cause kidney function loss, but effects of stenting on eGFR and clinical events associated with CKD are uncertain. Our study objectives were to determine effects of stenting on eGFR and predictors of clinical events. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants (n=931) in the Cardiovascular Outcomes in Renal Artery Stenosis Trial (from May of 2005 to September of 2012) had >60% atherosclerotic renal artery stenosis and systolic hypertension on two or more antihypertensive drugs and/or stage ≥3 CKD...
July 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27108247/coronary-artery-disease-is-a-predictor-of-progression-to-dialysis-in-patients-with-chronic-kidney-disease-type-2-diabetes-mellitus-and-anemia-%C3%A2-an-analysis-of-the-trial-to-reduce-cardiovascular-events-with-aranesp-therapy-treat
#13
Marwa A Sabe, Brian Claggett, Emmanuel A Burdmann, Akshay S Desai, Peter Ivanovich, Reshma Kewalramani, Eldrin F Lewis, John J V McMurray, Kurt A Olson, Patrick Parfrey, Scott D Solomon, Marc A Pfeffer
BACKGROUND: Although clear evidence shows that chronic kidney disease is a predictor of cardiovascular events, death, and accelerated coronary artery disease (CAD) progression, it remains unknown whether CAD is a predictor of progression of chronic kidney disease to end-stage renal disease. We sought to assess whether CAD adds prognostic information to established predictors of progression to dialysis in patients with chronic kidney disease, diabetes, and anemia. METHODS AND RESULTS: Using the previously described Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) population, we compared baseline characteristics of patients with and without CAD...
April 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26952289/high-urinary-sulfate-concentration-is-associated-with-reduced-risk-of-renal-disease-progression-in-type-2-diabetes
#14
Joost C van den Born, Anne-Roos S Frenay, Stephan J L Bakker, Andreas Pasch, Jan-Luuk Hillebrands, Hiddo J Lambers Heerspink, Harry van Goor
Diabetes is associated with a high incidence of microvascular disease, including nephropathy. Diabetic nephropathy is the most common cause of chronic kidney disease in the Western world. Sulfate in the urine is the metabolic end product of hydrogen sulfide (H2S), a recent discovered gaseous signaling molecule. Urinary sulfate has earlier shown beneficial predictive properties in renal transplant recipients. Based on the protective role of exogenous H2S in experimental models of diabetic nephropathy, we aimed to cross-sectionally investigate the association of sulfate with renal risk markers, and to prospectively investigate its predictive value for renal events in patients with diabetic nephropathy...
May 1, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/26906116/heme-oxygenase-1-in-kidney-health-and-disease
#15
Jeremie M Lever, Ravindra Boddu, James F George, Anupam Agarwal
SIGNIFICANCE: Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a considerable burden in healthcare. The heme oxygenase (HO) system plays an important role in regulating oxidative stress and is protective in a variety of human and animal models of kidney disease. Preclinical studies of the HO system have led to the development of several clinical trials targeting the enzyme or its products. RECENT ADVANCES: Connection of HO, ferritin, and other proteins involved in iron regulation has provided important insight into mechanisms of damage in AKI...
July 20, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/26774608/renal-outcomes-with-aliskiren-in-patients-with-type-2-diabetes-a-prespecified-secondary-analysis-of-the-altitude-randomised-controlled-trial
#16
Hiddo J L Heerspink, Frederik Persson, Barry M Brenner, Nish Chaturvedi, Patrick Brunel, John J McMurray, Akshay S Desai, Scott D Solomon, Marc A Pfeffer, Hans-Henrik Parving, Dick de Zeeuw
BACKGROUND: The primary results of the ALTITUDE trial showed no benefit of aliskiren on renal outcomes (doubling of serum creatinine and end-stage renal disease) when used as an adjunct to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) in patients with type 2 diabetes and chronic kidney disease or cardiovascular disease. We did a prespecified analysis of the ALTITUDE trial to analyse the effects of aliskiren on surrogate renal outcomes in all patients and on primary renal outcomes in subgroups of patients...
April 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/26569322/renin-angiotensin-aldosterone-system-blockade-in-diabetic-nephropathy-present-evidences
#17
REVIEW
Luz Lozano-Maneiro, Adriana Puente-García
Diabetic Kidney Disease (DKD) is the leading cause of chronic kidney disease in developed countries and its prevalence has increased dramatically in the past few decades. These patients are at an increased risk for premature death, cardiovascular disease, and other severe illnesses that result in frequent hospitalizations and increased health-care utilization. Although much progress has been made in slowing the progression of diabetic nephropathy, renal dysfunction and the development of end-stage renal disease remain major concerns in diabetes...
2015: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26520140/periodontal-disease-and-chronic-kidney-disease-among-aboriginal-adults-an-rct
#18
RANDOMIZED CONTROLLED TRIAL
Lisa Jamieson, Michael Skilton, Louise Maple-Brown, Kostas Kapellas, Lisa Askie, Jaqui Hughes, Peter Arrow, Sajiv Cherian, David Fernandes, Basant Pawar, Alex Brown, John Boffa, Wendy Hoy, David Harris, Nicole Mueller, Alan Cass
BACKGROUND: This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascular health, progression of renal disease and periodontal health over a 24-month follow-up. METHODS: The study will be a randomised controlled trial. All participants will receive the periodontal intervention benefits, with the delayed intervention group receiving periodontal treatment 24 months following baseline...
2015: BMC Nephrology
https://www.readbyqxmd.com/read/26359201/neurological-complications-in-chronic-kidney-disease-patients
#19
REVIEW
Jean-Marc Chillon, Ziad A Massy, Bénédicte Stengel
Chronic kidney disease (CKD) is associated with a high prevalence of cerebrovascular disorders such as stroke, white matter diseases, intracerebral microbleeds and cognitive impairment. This situation has been observed not only in end-stage renal disease patients but also in patients with mild or moderate CKD. The occurrence of cerebrovascular disorders may be linked to the presence of traditional and non-traditional cardiovascular risk factors in CKD. Here, we review current knowledge on the epidemiological aspects of CKD-associated neurological and cognitive disorders and discuss putative causes and potential treatment...
October 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26242375/phosphodiesterase-type-5-inhibitors-and-kidney-disease
#20
REVIEW
Baris Afsar, Alberto Ortiz, Adrian Covic, Abduzhappar Gaipov, Tarik Esen, David Goldsmith, Mehmet Kanbay
Chronic kidney disease (CKD) represents a worldwide health problem. Traditionally, the nephroprotective treatment for CKD aims to slow progression to end-stage renal disease and includes dietary protein restriction, correction of metabolic acidosis, and renin-angiotensin system blockers. However, current standard therapeutic options may not be enough for preventing CKD progression in a subset of patients making necessary to develop novel therapeutic options to further slow renal function loss. Phosphodiesterase type 5 (PDE5) inhibitors represent a class of drugs traditionally used to treat erectile dysfunction and pulmonary hypertension...
September 2015: International Urology and Nephrology
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