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Fractionated exhaled nitric oxide

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https://www.readbyqxmd.com/read/29150070/decreased-expression-of-indolamine-2-3-dioxygenase-in-childhood-allergic-asthma-and-its-inverse-correlation-with-fractional-concentration-of-exhaled-nitric-oxide
#1
Ying Hu, Zhiqiang Chen, Ling Jin, Mei Wang, Wei Liao
BACKGROUND: The tryptophan metabolic pathway mediated by indolamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, plays an important role in controlling the development of allergic inflammation. The fractional concentration of exhaled nitric oxide (FeNO) is closely associated with the allergic state and is extensively used for the clinical evaluation of airway allergic inflammation. Clinical trials have rarely assessed the expression of IDO in childhood allergic asthma and its correlation with FeNO...
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29149738/associations-of-urinary-polycyclic-aromatic-hydrocarbon-metabolites-with-fractional-exhaled-nitric-oxide-and-exhaled-carbon-monoxide-a-cross-sectional-study
#2
Yun Zhou, Yuewei Liu, Huizhen Sun, Jixuan Ma, Lili Xiao, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen
Exposure to Polycyclic aromatic hydrocarbons (PAHs) has been associated with inflammatory responses. Fractional exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) are both important inflammatory mediators especially in airways. However, few studies have investigated associations of PAH exposures with FeNO or eCO. Therefore, we aimed to quantify the associations of urinary PAH metabolites with FeNO and eCO levels, and investigate their potential effect modifiers by linear mixed models among 4133 participants from the Wuhan-Zhuhai cohort in China...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#3
Katri Backman, Hertta Ollikainen, Eija Piippo-Savolainen, Kirsi Nuolivirta, Matti Korppi
BACKGROUND: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29142522/drug-induced-eosinophilic-pneumonia-in-a-patient-with-crohn-s-disease-diagnosis-and-treatment-using-fraction-of-exhaled-nitric-oxide
#4
Jina Yeo, Hyun Sun Woo, Sang Min Lee, Yoon Jae Kim, Kwang An Kwon, Dong Kyun Park, Jung Ho Kim, Kyoung Oh Kim, Jun-Won Chung
Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with inflammatory bowel disease are very rare; to date, only 38 cases have been reported worldwide. We, herein, report a case involving a 26-year-old man who was diagnosed with eosinophilic pneumonia after using mesalazine and azathioprine for the treatment of Crohn's disease and recovered after treatment...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29133224/feno-and-exercise-testing-in-children-at-risk-of-asthma
#5
Ann-Marie Malby Schoos, Christina Figgé Christiansen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Lund Chawes
BACKGROUND: Exercise testing is the gold standard for diagnosing exercise-induced bronchoconstriction in children, but requires considerable cooperation and medical resources. Therefore, fraction of exhaled nitric oxide (FeNO) has been proposed as a tool to predict the need for exercise testing. OBJECTIVE: The objective of this study was to investigate the relationship between FeNO, exercise test results, and a history of respiratory symptoms during exercise in children at risk of asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29133220/effects-of-exercise-and-diet-in-nonobese-asthma-patients-a-randomized-controlled-trial
#6
Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer
BACKGROUND: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29128336/the-value-of-fractional-exhaled-nitric-oxide-and-forced-mid-expiratory-flow-as-predictive-markers-of-bronchial-hyperresponsiveness-in-adults-with-chronic-cough
#7
Wuping Bao, Xue Zhang, Chengjian Lv, Luhong Bao, Junfeng Yin, Zhixuan Huang, Bing Wang, Xin Zhou, Min Zhang
BACKGROUND: Bronchial provocation tests are standard for diagnosing the etiology of chronic cough, but they are time consuming and can induce severe bronchospasm. A safer and faster clinical examination to predict bronchial hyperresponsiveness (BHR) is needed. OBJECTIVE: The objective of this study was to investigate whether small-airway function tests can predict BHR in adult patients with chronic cough. METHODS: A retrospective, cross-sectional study of diagnoses made using spirometry and bronchial provocation test results was performed in 290 patients with chronic nonproductive cough...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29118577/associations-between-occupational-inhalation-risks-and-feno-levels-in-airway-obstruction-patients-results-from-the-national-health-and-nutrition-examination-survey-2007-2012
#8
Yi-Chih Huang, Mei-Chen Yang
Purpose: To investigate associations between occupational inhalation risks and fractional exhaled nitric oxide (FeNO) levels in patients with chronic obstructive pulmonary disease (COPD). Patients and methods: Data of 16,486 subjects who had undergone spirometry with pre-bronchodilator and post-bronchodilator lung function assessment were retrieved from the National Health and Nutrition Examination Survey, 2007-2012 database. After excluding 2,638 subjects with missing spirometry values, data of 13,336 subjects were included for analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29110960/the-clinical-role-of-fractional-exhaled-nitric-oxide-in-asthma-control
#9
Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Xintao Wang, Yoshinori Tanino, Mitsuru Munakata
BACKGROUND: The potential role and characteristics of fractional exhaled nitric oxide (FeNO) remain unclear in the treatment of asthma. OBJECTIVE: To explore the clinical role of FeNO in asthmatic treatment. METHODS: We evaluated whether the mean or change of FeNO levels in the treatment period is associated with other conventional control parameters and predicted some clinical outcomes of asthma. We retrospectively analyzed the mean and percentage change of FeNO levels in the first 5 measurements at our hospital...
October 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29108938/fractional-exhaled-nitric-oxide-as-a-predictor-of-response-to-inhaled-corticosteroids-in-patients-with-non-specific-respiratory-symptoms-and-insignificant-bronchodilator-reversibility-a-randomised-controlled-trial
#10
David B Price, Roland Buhl, Adrian Chan, Daryl Freeman, Elizabeth Gardener, Clifford Godley, Kevin Gruffydd-Jones, Lorcan McGarvey, Ken Ohta, Dermot Ryan, Jörgen Syk, Ngiap Chuan Tan, TzeLee Tan, Mike Thomas, Sen Yang, Priyanka Raju Konduru, Marcus Ngantcha, Martina Stagno d'Alcontres, Therese S Lapperre
BACKGROUND: Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. METHODS: In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18-80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore...
November 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29074699/fractional-exhaled-nitric-oxide-monitoring-in-paediatric-asthma-management
#11
Nicholas R Jones, Kay Wang, Yaling Yang, Carl Heneghan, Christopher P Price, Ann Van den Bruel, Annette Plüddemann
No abstract text is available yet for this article.
November 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29068321/relationship-between-total-serum-immunoglobulin-e-levels-fractional-exhaled-breath-nitric-oxide-levels-and-absolute-blood-eosinophil-counts-in-atopic-and-non-atopic-asthma-a-controlled-comparative-study
#12
Sanjeet Krishna Shrestha, Arne Drews, Lucky Sharma, Subash Pant, Sanjeev Shrestha, Arpana Neopane
ABSTRACT Introduction Asthma is a prevalent non communicable disease both in low and high income countries, including Nepal. Total serum immunoglobulin E levels and peripheral blood absolute eosinophil counts are known inflammatory markers of asthma. And Fractional Exhaled Nitric Oxide measure in breath has also been proposed as a non-invasive biomarker to assess eosinophilic airway inflammation. This study explores the correlation between these three variables with intent that one may replace the other in resource limited setup...
October 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29066918/asthma-with-bronchial-hypersecretion-expression-of-mucins-and-toll-like-receptors-in-sputum-and-blood
#13
Astrid Crespo-Lessmann, Eder Mateus, Montserrat Torrejón, Alicia Belda, Jordi Giner, Silvia Vidal, Oriol Sibila, Vicente Plaza
Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). OBJECTIVES: 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29066290/phenotype-classification-using-the-combination-of-lung-sound-analysis-and-fractional-exhaled-nitric-oxide-for-evaluating-asthma-treatment
#14
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
BACKGROUND: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. METHODS: A total of 233 patients with bronchial asthma were included...
October 21, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#15
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29046188/association-of-imbalance-of-effector-t-cells-and-regulatory-cells-with-the-severity-of-asthma-and-allergic-rhinitis-in-children
#16
Fei Huang, Jia-Ning Yin, Hong-Bo Wang, Shou-Yue Liu, Ya-Nan Li
PURPOSE: This study investigated the frequency and absolute numbers of different subsets of peripheral blood cells, including CD4+ T cells and CD19+ interleukin (IL) 10+ B regulatory cells (Breg) and their potential association with clinical laboratory measurements in children diagnosed with simple asthma or asthma plus allergic rhinitis (AR). METHOD: The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29042872/accuracy-of-maximal-expiratory-flow-volume-curve-curvilinearity-and-fractional-exhaled-nitric-oxide-for-detection-of-children-with-atopic-asthma
#17
Sang Hoo Park, Min Ji Im, Sang-Yong Eom, Youn-Soo Hahn
PURPOSE: Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals. METHODS: FeNO and angle β, which characterizes the general configuration of the MEFV curve, were determined in 119 steroid-naïve individuals with atopic asthma aged 8 to 16 years, and in 92 age-matched healthy controls...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29042800/postpartum-airway-responsiveness-and-exacerbation-of-asthma-during-pregnancy-a-pilot-study
#18
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Airway responsiveness and inflammation are associated with the clinical manifestations of asthma and the response to pharmacological therapy. OBJECTIVE: To investigate if airway responsiveness and inflammatory characteristics are related to asthma exacerbations during pregnancy. MATERIALS AND METHODS: In women with asthma who were prescribed controller medication and monitored closely during pregnancy, the risk of exacerbations was analyzed in relation to postpartum measures of fractional exhaled nitric oxide (FENO), skin prick test reactivity, static and dynamic lung volumes, diffusing capacity for carbon monoxide, bronchial responsiveness to inhaled mannitol, and inflammatory characteristics in induced sputum...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29042799/asthma-symptoms-mannitol-reactivity-and-exercise-induced-bronchoconstriction-in-adolescent-swimmers-versus-tennis-players
#19
Kerstin Romberg, Ellen Tufvesson, Leif Bjermer
BACKGROUND: Strenuous physical activity at an elite level is associated with an increased risk for asthma and, in some sports, also prevalence of allergies. The aim of this study was to investigate the prevalence of asthma and allergy among elite swimmers and tennis players and compare airway hyperreactivity to mannitol and exercise. MATERIALS AND METHODS: One hundred and one adolescent swimmers and 86 tennis players answered a questionnaire about respiratory symptoms and allergy and performed mannitol challenge and sport-specific exercise challenge...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29037302/feno-levels-increase-with-degree-of-sensitisation-in-apprentices-at-risk-of-occupational-asthma
#20
P Wild, H Mével, E Penven, D Zmirou-Navier, A Barbaud, A Bohadana, C Paris
BACKGROUND: Atopy has emerged as a major determinant of airway inflammation. OBJECTIVE: To examine whether early markers of occupational asthma increase with degree of sensitisation. METHOD: This study was a prospective follow-up study of apprentices in baking, pastry-cooking and hairdressing during their 2-year apprenticeship. Four visits were conducted to administer a standardised questionnaire, a methacholine challenge test to assess bronchial hyperresponsiveness (BHR) and to measure fractional exhaled nitric oxide (FeNO)...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
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