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Fractionated exhaled nitric oxide

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https://www.readbyqxmd.com/read/28731412/lung-sound-analysis-is-useful-for-monitoring-therapy-in-patients-with-bronchial-asthma
#1
T Shimoda, Y Obase, Y Nagasaka, H Nakano, R Kishikawa, T Iwanaga
BACKGROUND AND OBJECTIVE: Lung sound analysis (LSA) has been reported to be useful for predicting airway obstruction and inflammation in patients with bronchial asthma. Objectives: We examined whether the exhalation-to-inhalation sound pressure ratio in the middle frequency range (200-400 Hz) (E/I MF) is useful for monitoring therapy in patients with asthma. METHODS: The study population comprised 84 patients with mild to moderate asthma whose LSA data were available before and after 1 year of daily treatment with (budesonide 800 μg)...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28730377/influence-of-vitamin-d-and-cotinine-on-t-regulatory-cells-and-asthma-severity-in-children
#2
Bolesław Kalicki, Agata Wawrzyniak, Agnieszka Lipińska-Opałka, Sławomir Lewicki, Robert Zdanowski
Asthma is a common chronic respiratory diseases in children. Understanding the immune mechanisms of epigenetic factors may contribute to a better control of asthma. This study seeks to determine the effects of serum vitamin D and urine cotinine on asthma severity and on T regulatory cells (Tregs) and other immune-related factors such as CD3, CD4, CD8, CD19, CD16/56, and anti-CD3 HLA-DR3. The study involved 34 children with asthma. Disease severity was assessed with the Asthma Control Test, spirometry, and the fractional exhaled nitric oxide (FeNO)...
July 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28715576/association-of-ozone-exposure-with-cardiorespiratory-pathophysiologic-mechanisms-in-healthy-adults
#3
Drew B Day, Jianbang Xiang, Jinhan Mo, Feng Li, Mingkei Chung, Jicheng Gong, Charles J Weschler, Pamela A Ohman-Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Jim Zhang
Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28704185/phenotypes-determined-by-cluster-analysis-in-moderate-to-severe-bronchial-asthma
#4
Vania M Youroukova, Denitsa G Dimitrova, Anna D Valerieva, Spaska S Lesichkova, Tsvetelina V Velikova, Ekaterina I Ivanova-Todorova, Kalina D Tumangelova-Yuzeir
BACKGROUND: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. AIM: To identify phenotypes using cluster analysis in moderate to severe bronchial asthma and to compare differences in clinical, physiological, immunological and inflammatory data between the clusters. PATIENTS AND METHODS: Forty adult patients with moderate to severe bronchial asthma out of exacerbation were included...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28701890/relationship-between-oxidative-stress-physical-activity-and-vitamin-intake-in-patients-with-asthma
#5
Akira Yamasaki, Yuji Kawasaki, Kenichi Takeda, Tomoya Harada, Yasuyuki Hasegawa, Takehito Fukushima, Ryota Okazaki, Haruhiko Makino, Yoshihiro Funaki, Yuriko Sueda, Akihiro Yamamoto, Jun Kurai, Masanari Watanabe, Eiji Shimizu
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28686173/comparison-of-fractional-exhaled-nitric-oxide-levels-in-chronic-obstructive-pulmonary-disease-bronchial-asthma-and-healthy-subjects-of-nepal
#6
Sanjeet Krishna Shrestha, Sanjeev Shrestha, Lucky Sharma, Subash Pant, Arpana Neopane
INTRODUCTION Fractional exhaled nitric oxide levels in exhaled breath can indicate on-going eosinophilic airway inflammation, specifically in asthma. But, its utility is being explored for airway centric inflammations including chronic obstructive pulmonary disease. Normal levels of fractional exhaled nitric oxide (FENO50) have been defined in different studies but not in Nepal. This study compares fractional exhaled nitric oxide levels in all three groups: normal, asthma and chronic obstructive pulmonary disease...
July 7, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28663317/a-sputum-gene-expression-signature-predicts-oral-corticosteroid-response%C3%A2-in%C3%A2-asthma
#7
Bronwyn S Berthon, Peter G Gibson, Lisa G Wood, Lesley K MacDonald-Wicks, Katherine J Baines
Biomarkers that predict responses to oral corticosteroids (OCS) facilitate patient selection for asthma treatment. We hypothesised that asthma patients would respond differently to OCS therapy, with biomarkers and inflammometry predicting response.Adults with stable asthma underwent a randomised controlled cross-over trial of 50 mg prednisolone daily for 10 days (n=55). A six-gene expression biomarker signature (CLC, CPA3, DNASE1L3, IL1B, ALPL and CXCR2) in induced sputum, and eosinophils in blood and sputum were assessed and predictors of response were investigated (changes in forced expiratory volume in 1 s (ΔFEV1), six-item Asthma Control Questionnaire score (ΔACQ6) or exhaled nitric oxide fraction (ΔFeNO))...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28645522/acute-effects-of-ambient-temperature-and-particulate-air-pollution-on-fractional-exhaled-nitric-oxide-a-panel-study-among-diabetic-patients-in-shanghai-china
#8
Huichu Li, Hongjian Bai, Changyuan Yang, Renjie Chen, Cuicui Wang, Zhuohui Zhao, Haidong Kan
BACKGROUND: Epidemiological studies have shown the associations of ambient temperature and particulate matter (PM) air pollution with respiratory morbidity and mortality. However, the underlying mechanisms have not been well characterized. The aim of this study is to investigate the associations of temperature and fine and coarse PM with fractional exhaled nitric oxide (FeNO), a well-established biomarker of respiratory inflammation. METHODS: We conducted a longitudinal panel study involving six repeated FeNO tests among 33 type 2 diabetes mellitus patients from April to June 2013 in Shanghai, China...
June 20, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28636794/differences-and-similarities-between-bronchopulmonary-dysplasia-and-asthma-in-schoolchildren
#9
Björn Nordlund, Anna James, Christina Ebersjö, Gunilla Hedlin, Eva B Broström
BACKGROUND: The long-term respiratory characteristics of ex-preterm children with bronchopulmonary dysplasia (BPD) are not established. The objective of this study was to describe hallmarks of BPD at school age in comparison to children with atopic asthma. METHODS: This study was a cross-sectional descriptive comparative study in a hospital-based setting. Thirty schoolchildren diagnosed with BPD (10.4 years/born at 26.6 weeks' gestation) and 30 age- and sex-matched children with asthma and sensitized to airborne allergens (IgE >0...
June 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28628045/cardio-respiratory-effects-of-air-pollution-in-a-panel-study-of-outdoor-physical-activity-and-health-in-rural-older-adults
#10
David M Stieb, Robin Shutt, Lisa Kauri, Sarah Mason, Li Chen, Mieczyslaw Szyszkowicz, Nina A Dobbin, Marc Rigden, Branka Jovic, Marie Mulholland, Martin S Green, Ling Liu, Guillaume Pelletier, Scott A Weichenthal, Robert E Dales, Isaac Luginaah
OBJECTIVE: To examine cardio-respiratory effects of air pollution in rural older adults exercising outdoors. METHODS: Adults 55 and over completed measurements of blood pressure, peak expiratory flow and oximetry daily, and of heart rate variability, endothelial function, spirometry, fraction of exhaled nitric oxide and urinary oxidative stress markers weekly, before and after outdoor exercise, for 10 weeks. Data were analyzed using linear mixed effect models. RESULTS: Pooled estimates combining 2013 (n = 36 participants) and 2014 (n = 41) indicated that an interquartile increase in the air quality health index (AQHI) was associated with a significant (P < 0...
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28606216/comparable-reductions-in-hyperpnoea-induced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-6%C3%A2-2-and-3%C3%A2-1-g-d-of-long-chain-n-3-pufa-in-adults-with-asthma
#11
Neil C Williams, Kirsty A Hunter, Dominick E Shaw, Kim G Jackson, Graham R Sharpe, Michael A Johnson
Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28592098/-the-effect-of-short-term-exposure-to-ambient-no-2-on-lung-function-and-fractional-exhaled-nitric-oxide-in-33-chronic-obstructive-pulmonary-disease-patients
#12
J Shan, Y Ni, W Dong, J H Xu, L Pan, H Y Li, X Yang, S W Wu, Y H Chen, F R Deng, X B Guo
Objectives: To investigate the effect of short-term exposure to ambient NO(2) has influence on lung function and fractional exhaled nitric oxide (FeNO) in chronic obstructive pulmonary disease (COPD) patients. Methods: A panel of doctor-diagnosed stable COPD patients (n=33) were recruited and repeatedly measured for lung function and FeNO from December 2013 to October 2014. The patients who lived in Beijing for more than one year and aged between 60 and 85 years old were included in the study. We excluded patients with asthma, bronchial tensor, lung cancer and other respiratory disorders other than chronic obstructive pulmonary disease and occupational exposure and chest trauma surgery patients...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28588744/effect-of-personal-exposure-to-black-carbon-on-changes-in-allergic-asthma-gene-methylation-measured-5%C3%A2-days-later-in-urban-children-importance-of-allergic-sensitization
#13
Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R Jezioro, Matthew Perzanowski, Frederica P Perera, Steven N Chillrud, Rachel L Miller
BACKGROUND: Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not been fully elucidated. Our objective was to determine the timeline of black carbon (BC) exposure, measured by personal sampling, on DNA methylation of allergic asthma genes 5 days later to capture usual weather variations and differences related to changes in behavior and activities...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28584938/the-effect-of-sleep-duration-on-exhaled-nitric-oxide-levels-in-u-s-adults
#14
Jensen H Hyde, Rehan Qayyum
PURPOSE: Poor sleep quality and duration are associated with systemic endothelial dysfunction. However, an association between poor sleep and pulmonary endothelial dysfunction has not been elucidated. We sought to determine if there is a relationship between sleep duration and fractional exhaled nitric oxide (FeNO) concentrations as a surrogate for pulmonary endothelial function. METHODS: We used three National Health and Nutrition Examination Survey (NHANES) cycles (2007-2012)...
June 6, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28579561/normal-values-of-offline-exhaled-and-nasal-nitric-oxide-in-healthy-children-and-teens-using-chemiluminescence
#15
Awen Menou, Diane Babeanu, Henry-Nicolas Paruit, Aline Ordureau, Sophie Guillard, Arnaud Christian Chambellan
Nitric oxide (NO) can be used to detect respiratory or ciliary diseases. Fractional exhaled nitric oxide (FeNO) measurement can reflect ongoing eosinophilic airway inflammation and has a diagnostic utility as a test for asthma screening and follow-up while nasal nitric oxide (nNO) is a valuable screening tool for the diagnosis of Primary Ciliary Dyskinesia (PCD). The possibility to collect airway gas samples in an offline manner offers the advantage to extend these measures and improve the screening and management of these diseases, but normal values from healthy children and teens remain sparse...
June 5, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28552381/influence-of-maternal-body-mass-index-and-macrophage-activation-on-asthma-exacerbations-in-pregnancy
#16
Vanessa E Murphy, Megan E Jensen, Heather Powell, Peter G Gibson
BACKGROUND: Obesity is a risk factor for exacerbations of asthma, but the mechanisms of this effect in pregnancy are unknown. OBJECTIVE: This study determined the influence of maternal body mass index, gestational weight gain, eosinophilic inflammation, and systemic macrophage activation on the risk of exacerbations during pregnancy. METHODS: Women with asthma (n = 164) participated in the study. Body mass index recorded at baseline (17 weeks gestation) was categorized as healthy weight (18...
May 25, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28544706/exhaled-nitric-oxide-pulmonary-function-and-disease-activity-in-children-with-systemic-lupus-erythematosus
#17
Jitladda Deerojanawong, Pitchaya Leartphichalak, Ankanee Chanakul, Suchada Sritippayawan, Rujipat Samransamruajkit
AIM: To determine the association among fractional exhaled nitric oxide (FENO), pulmonary function, and disease activity in children with systemic lupus erythematosus (SLE). METHODS: Children aged 7-18 years, diagnosed with SLE under the criteria of the American Rheumatism Association (revised 2012), were enrolled. All eligible participants had disease activity, FENO, and pulmonary function evaluated and re-evaluated at 6-month follow-up. RESULTS: Twenty-four children (95...
May 22, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28527680/sensitivity-of-salivary-hydrogen-sulfide-to-psychological-stress-and-its-association-with-exhaled-nitric-oxide-and-affect
#18
Juliet L Kroll, Chelsey A Werchan, Audrey G Reeves, Kevin J Bruemmer, Alexander R Lippert, Thomas Ritz
BACKGROUND: Hydrogen sulfide (H2S) is the third gasotransmitter recently discovered after nitric oxide (NO) and carbon monoxide. Both NO and H2S are involved in multiple physiological functions. Whereas NO has been shown to vary with psychological stress, the influence of stress on H2S and the relationship between H2S and NO are unknown. We therefore examined levels of salivary H2S and NO in response to a stressful final academic exam period. METHODS: Measurements of stress, negative affect, and fraction of exhaled NO (FENO), were obtained from students (N=16) and saliva was collected at three time points: low-stress period in the semester, early exam period, and late exam period...
May 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28524604/prevalence-of-high-fractional-exhaled-nitric-oxide-among-us-youth-with-asthma
#19
Duong T Nguyen, Brian K Kit, Debra Brody, Lara J Akinbami
BACKGROUND: High fractional exhaled nitric oxide (FeNO) is an indicator of poor asthma control and has been proposed as a non-invasive assessment tool to guide asthma management. OBJECTIVE: We aimed to describe the prevalence of and factors associated with high FeNO among US youth with asthma. METHODS: Data from 716 children and adolescents with asthma ages 6-19 years who participated in the 2007-2012 National Health and Nutrition Examination Survey were analyzed...
June 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28515402/differences-in-fraction-of-exhaled-nitric-oxide-values-measured-by-two-hand-helded-analyzers-nobreath-%C3%A2-and-niox-vero-%C3%A2
#20
Takahiro Tsuburai, Yousuke Kamide, Yuto Nakamura, Yasuhiro Tomita, Yuto Hamada, Kentaro Watai, Hiroaki Hayashi, Kiyoshi Sekiya, Chihiro Mitsui, Yuma Fukutomi, Akio Mori, Masami Taniguchi
BACKGROUND: The fraction of exhaled nitric oxide (FENO) is a useful marker of asthma control. The FENO measurement with two hand-helded analyzers (NObreath(®) and NIOX Vero(®)) may be more affordable, no studies have examined the differences in FENO values measured with those methods in adult. METHODS: The study population comprised 44 subjects at our outpatient clinic. FeNO values (FENOb and FENOv) were measured by two methods (NObreath(®) and NIOX Vero(®))...
2017: Arerugī, [Allergy]
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