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Fractionated exhaled nitric oxide

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https://www.readbyqxmd.com/read/29348180/persistently-elevated-exhaled-nitric-oxide-fraction-is-associated-with-increased-risk-of-exacerbation-in-copd
#1
Bernardino Alcázar-Navarrete, Oliverio Ruiz Rodríguez, Pablo Conde Baena, Pedro José Romero Palacios, Alvar Agusti
Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO®, Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO ≥20 ppb...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29328030/modern-approaches-to-fractional-exhaled-nitric-oxide-as-a-useful-biomarker-for-allergic-asthma-phenotyping-and-management
#2
N Mgaloblishvili, M Gotua
Asthma is a pathologically heterogeneous disease, consisting of several phenotypes. Different types of airway inflammation are the cornerstone feature of this condition. Fraction of nitric oxide in exhaled air (FENO) has been proposed as a noninvasive, specific biomarker for eosinophilic airway inflammation and has been shown to be elevated in patients with allergic asthma phenotype. More recent studies indicate that FeNO identifies T-helper cell type 2 (Th2)-mediated airway inflammation with a high predictive value for identifying inhaled corticosteroid (ICS) responsive airway inflammation...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326334/clinical-and-inflammatory-phenotyping-by-breathomics-in-chronic-airway-diseases-irrespective-of-the-diagnostic-label
#3
Rianne de Vries, Yennece W F Dagelet, Pien Spoor, Erik Snoey, Patrick M C Jak, Paul Brinkman, Erica Dijkers, Simon K Bootsma, Fred Elskamp, Frans H C de Jongh, Eric G Haarman, Johannes C C M In 't Veen, Anke-Hilse Maitland-van der Zee, Peter J Sterk
Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set.This was a multicentre cross-sectional study in which exhaled breath from asthma and COPD patients (n=435; training n=321 and validation n=114) was analysed using eNose technology...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29324380/estimated-individual-inhaled-dose-of-fine-particles-and-indicators-of-lung-function-a-pilot-study-among-chinese-young-adults
#4
Tian Xu, Jian Hou, Juan Cheng, Runbo Zhang, Wenjun Yin, Cheng Huang, Xiaochuan Zhu, Weihong Chen, Jing Yuan
Fine particle (PM2.5)-related lung damage has been reported in most studies regarding environmental or personal PM2.5 concentrations. To assess effects of personal PM2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM2.5 based on their microenvironmetal PM2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day...
January 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29304558/reduction-of-feno-by-tap-water-and-carbonated-water-mouthwashes-magnitude-and-time-course
#5
Paul Guenther Lassmann-Klee, Tuula Lindholm, Markus Metsälä, Lauri Halonen, Anssi Raimo Antero Sovijärvi, Päivi Piirilä
Fractional exhaled nitric oxide (FENO) assesses eosinophilic inflammation of the airways, but FENO values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure FENO and compare the effect of two different mouthwashes on FENO and analyse the duration of the effect. FENO was measured in 12 randomized volunteers (healthy or asthmatic subjects) with a NIOX VERO® analyser at an expiratory flow rate of 50 mL/s. After a baseline measurement, a mouthwash was performed either with tap water or carbonated water and was measured during 20 min in 2 min intervals...
January 5, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29301349/associations-of-serum-25-oh-d-concentrations-with-lung-function-airway-inflammation-and-common-cold-in-the-general-population
#6
Rachida Rafiq, Willemien Thijs, Robert Prein, Renate T de Jongh, Christian Taube, Pieter S Hiemstra, Renée de Mutsert, Martin den Heijer
Vitamin D is hypothesized to have a beneficial effect on lung function and respiratory infections. The aim of this study was to assess the relationship of serum 25-hydroxyvitamin D (25(OH)D) concentrations with lung function, airway inflammation and common colds. We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. We included participants with measurements of serum 25(OH)D, Forced Expiratory Volume in 1 s (FEV₁), Forced Vital Capacity (FVC), Fractional Exhaled Nitric Oxide (FeNO), and data on self-reported common colds (n = 6138)...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29296089/elevated-fractional-exhaled-nitric-oxide-and-blood-eosinophil-counts-are-associated-with-a-17q21-asthma-risk-allele-in-adult-subjects
#7
Elizabeth A Schwantes, Michael D Evans, Alex Cuskey, Alex Burford, Judith A Smith, Robert F Lemanske, Nizar N Jarjour, Sameer K Mathur
Background and objectives: Genome-wide association studies identified single-nucleotide polymorphisms (SNPs) at the 17q21 locus conferring increased risk for childhood-onset asthma. Little is known about how these SNPs impact adult asthma patients. We sought to examine an adult population for associations between rs7216389 (17q21-associated SNP) and features of asthma including fractional exhaled nitric oxide (FeNO), eosinophil counts, and age of asthma onset. Methods: Subjects were genotyped at SNP rs7216389...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29290515/risk-factors-and-clinical-outcomes-associated-with-fixed-airflow-obstruction-in-older-adults-with-asthma
#8
Gregory H Bennett, Laurie Carpenter, Wei Hao, Peter Song, Joel Steinberg, Alan P Baptist
BACKGROUND: Asthma in older adults is associated with increased morbidity and mortality compared with asthma in younger patients. Fixed airflow obstruction (FAO) is associated with decreased survival in younger patients, but its significance remains unclear in older adults with asthma. OBJECTIVE: To identify risk factors and outcomes related to FAO in older adults with asthma. METHODS: Subjects older than 55 years with a physician diagnosis of persistent asthma were evaluated...
December 28, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29283360/the-influence-of-dilution-on-the-offline-measurement-of-exhaled-nitric-oxide
#9
Victoria MacBean, Dharmika Pooranampillai, Catherine Howard, Alan Charles Lunt, Anne Greenough
Measurement of fractional exhaled nitric oxide (FeNO) is used to determine the presence and severity of eosinophilic airway inflammation in asthma and other wheezing illnesses. The gold standard of online measurement during a single prolonged exhalation is not suitable for use in young children. The international guidelines for offline measurements recommend collection of exhaled gas in an appropriate reservoir for later analysis in young children. The apparatus required for gas collection, however, creates dead space within the system, which may result in sample dilution and hence inaccuracy...
December 28, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29279062/comparison-of-the-effect-of-5-grass-pollen-sublingual-immunotherapy-tablets-and-drops-in-children-with-rhinoconjunctivitis
#10
Joanna Jerzynska, Wlodzimierz Stelmach, Pawel Majak, Rafal Stelmach, Anna Janas, Iwona Stelmach
BACKGROUND: One of the most important aspects of sublingual immunotherapy (SLIT) is the regimen of administration. AIM: To find any differences in symptom-medication scores between the two groups of SLIT tablets and drops, given pre-coseasonally (starting 8 weeks before the pollen season) in children with rhinoconjunctivitis allergy to grass pollen. The secondary outcome were the differences in lung function and induction of T-regulatory forkhead box P3 (FOXP3) positive cells...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29279057/characterizing-patients-with-asthma-who-received-global-initiative-for-asthma-steps-4-5-therapy-and-managed-in-a-specialty-care-setting
#11
Brian Stone, Jill R Davis, Frank Trudo, Bradd Schiffman, Carlos Alzola, David Brown, Kathleen M Fox
BACKGROUND: Severe asthma is recognized in the European Respiratory Society/American Thoracic Society guidelines as a major unmet need in the management of asthma. OBJECTIVE: The study objective was to describe the clinical burden of Global Initiative for Asthma (GINA) steps 4-5 asthma for patients treated by specialists in the U.S. community setting. METHODS: Patients, ages ≥12 years, with asthma who received GINA step 4 or 5 treatment and were treated at a large U...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29278953/reduction-in-exhaled-nitric-oxide-tracks-improved-patient-inhaler-compliance-in-difficult-asthma-a-case-study
#12
Eoin Hunt, Deirdre Flynn, Elaine MacHale, Richard W Costello, Desmond M Murphy
INTRODUCTION: Exhaled nitric oxide is believed be a useful surrogate for airways inflammation while non-adherence with therapy is known to be associated with worsening of asthma control. CASE: We present the case of a 49-year-old female with steroid-dependent asthma and an exacerbation rate of >20/year. She was enrolled in a 3-month-long prospective study using a validated diagnostic inhaler device that provided objective evidence of inhaler compliance. Fractional exhaled nitric oxide (FeNO), peak expiratory flow rates, asthma control questionnaires were measured throughout the study period...
December 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29275031/the-diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-testing-in-asthma-a-systematic-review-and-meta-analyses
#13
Zhen Wang, Paolo T Pianosi, Karina A Keogh, Feras Zaiem, Mouaz Alsawas, Fares Alahdab, Jehad Almasri, Khaled Mohammed, Laura Larrea-Mantilla, Wigdan Farah, Lubna Daraz, Patricia Barrionuevo, Allison S Morrow, Larry J Prokop, Mohammad Hassan Murad
OBJECTIVE: To evaluate the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) measurement in individuals with suspected asthma. METHODS: We searched MEDLINE, EMBASE, PsycINFO, Cochrane databases, and SciVerse Scopus from the databases' inception through April 4, 2017, for studies that enrolled patients aged 5 years and older with suspected asthma and evaluated FeNO diagnostic accuracy. Independent reviewers selected studies and extracted data. We used the symmetric hierarchical summary receiver operating characteristic models to estimate test performance...
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29273668/investigating-fractional-exhaled-nitric-oxide-feno-in-chronic-obstructive-pulmonary-disease-copd-and-asthma-copd-overlap-aco-a-scoping-review-protocol
#14
Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi, Nafiseh Naderi, Miriam Barrecheguren, Abolfazl Dehghan, Jean Bourbeau
INTRODUCTION: During the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma-COPD overlap (ACO) is still unclear and needs to be defined...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29248433/physiotherapy-breathing-retraining-for-asthma-a-randomised-controlled-trial
#15
Anne Bruton, Amanda Lee, Lucy Yardley, James Raftery, Emily Arden-Close, Sarah Kirby, Shihua Zhu, Manimekalai Thiruvothiyur, Frances Webley, Lyn Taylor, Denise Gibson, Guiqing Yao, Mark Stafford-Watson, Jenny Versnel, Michael Moore, Steve George, Paul Little, Ratko Djukanovic, David Price, Ian D Pavord, Stephen T Holgate, Mike Thomas
BACKGROUND: Despite effective pharmacotherapy, asthma continues to impair quality of life for most patients. Non-pharmacological approaches, including breathing retraining, are therefore of great interest to patients. However, clinicians rarely advocate breathing retraining and access to this intervention is restricted for most patients due to the limited availability of suitable physiotherapists and poor integration of breathing retraining into standard care. We aimed to assess the effectiveness of a digital self-guided breathing retraining intervention...
December 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29231775/the-airway-hyperresponsiveness-to-methacholine-may-be-predicted-by-impulse-oscillometry-and-plethysmography-in-children-with-well-controlled-asthma
#16
Tugba Arıkoglu, Ayyuce Unlu, Didem Derici Yıldırım, Semanur Kuyucu
OBJECTIVE: Airway hyperresponsiveness (AHR) is a hallmark of asthma. Methacholine challenge test which is mostly used to confirm AHR is not routinely available. The aim of this study was to investigate the predictive values of fractional exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and plethysmography for the assessment of AHR in children with well-controlled asthma. METHODS: 60 children with controlled allergic asthma aged 6-18 years participated in the study...
December 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29223300/toxocara-species-exposure-symptoms-of-asthma-and-fractional-exhaled-nitric-oxide-in-the-us-population
#17
Funmilola Ogundipe, Edward Christian Anselm Hennis, Alem Mehari, Richard F Gillum
No abstract text is available yet for this article.
December 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29223148/exhaled-nitric-oxide-helps-discriminating-asthmatic-children-with-and-without-positive-specific-ige-to-aeroallergens
#18
Li-Ching Fang, Shyh-Dar Shyur, Jun Yang, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29217598/phenotypes-of-symptomatic-airways-disease-in-china-and-new-zealand
#19
James Fingleton, Kewu Huang, Mark Weatherall, Yanfei Guo, Stefan Ivanov, Piet Bruijnzeel, Hong Zhang, Wei Wang, Richard Beasley, Chen Wang
It is uncertain whether phenotypes of asthma and chronic obstructive pulmonary disease (COPD) vary between populations with different genetic and environmental characteristics. Here, our objective was to compare the phenotypes of airways disease in two separate populations.This was a cross-sectional observational study in adult populations from New Zealand and China. Participants aged 40-75 years who reported wheeze and breathlessness in the last 12 months were randomly selected from the general population and underwent detailed characterisation...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29196085/technology-interventions-for-nonadherence-new-approaches-to-an-old-problem
#20
Bruce G Bender
Nonadherence to asthma medications is well recognized. Interventions to improve adherence, however, have been only moderately successful and are not often adopted because of limited provider time, training, or institutional support. The potential for mobile communication technology to improve adherence has gathered sharply growing interest. Technology-based adherence tracking devices have been in existence for almost 3 decades, but have only recently reached a level of reliability and utility to be considered in allergy practice...
November 29, 2017: Journal of Allergy and Clinical Immunology in Practice
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