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Fractionated exhaled nitric oxide

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https://www.readbyqxmd.com/read/29786927/the-exhaled-nitric-oxide-and-mannitol-test-to-predict-exercise-induced-bronchoconstriction
#1
Kyubo Kim, Hong Je Cho, Jung Won Yoon, Sun Hee Choi, Youn Ho Sheen, ManYong Han, Heysung Baek
BACKGROUND: Exercise-induced bronchoconstriction (EIB) is diagnosed via exercise challenge on a treadmill. However, such testing requires complex equipment and sufficient healthcare resources. The fraction of exhaled nitric oxide (FeNO) test and mannitol bronchial provocation test (BPT) may serve as a surrogate of exercise testing. METHODS: We compared the diagnostic utilities of the FeNO test and mannitol BPT in predicting EIB in asthmatic children. We retrospectively analysed data from 60 asthmatic children aged 6-16 years...
May 22, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29785255/feasibility-of-high-intensity-training-in-asthma
#2
L L Toennesen, E D Soerensen, M Hostrup, C Porsbjerg, J Bangsbo, V Backer
Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2 max)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29775687/effects-of-bronchodilation-on-biomarkers-of-peripheral-airway-inflammation-in-copd
#3
Pierachille Santus, Dejan Radovanovic, Susanna Mascetti, Alessia Pauletti, Vincenzo Valenti, Marco Mantero, Alberto Papi, Marco Contoli
Peripheral airway inflammation and dysfunction are key elements in the pathogenesis of COPD. The exhaled alveolar fraction of nitric oxide (CANO) is an indirect biomarker of lung peripheral inflammation. We tested whether inhaled long-acting bronchodilators (LABA) can affect CANO and we evaluated correlations with lung mechanics in patients with COPD. Two-centre, randomised, double blind, crossover study including COPD patients with moderate-to-severe airflow obstruction. Following a pharmacological washout, multi-flow exhaled fraction of NO (FENO), plethysmography, lung diffusion (DLCO), single breath nitrogen washout test and dyspnoea were measured in a crossover manner at baseline and 30, 60 and 180 minutes following administration of salmeterol (Sal) or formoterol fumarate (FF)...
May 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29754974/implication-of-fraction-of-exhaled-nitric-oxide-and-blood-eosinophil-count-in-severe-asthma
#4
Tomoyuki Soma, Hidetoshi Iemura, Erika Naito, Sachiko Miyauchi, Yoshitaka Uchida, Kazuyuki Nakagome, Makoto Nagata
BACKGROUND: Severe asthma is a complex disease with heterogeneous features and involves type 2 airway inflammation, including eosinophil accumulation. Surrogate biomarkers, fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (b-EOS), may predict eosinophilic airway inflammation. Here we investigated clinical characteristics of severe asthma phenotype using a combined analysis of FeNO and b-EOS. METHODS: This retrospective study examined clinical data of patients with severe asthma (N = 107; median age, 64 years) treated at Saitama Medical University Hospital from 2009 to 2016...
May 10, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29746003/ige-sensitisation-to-food-allergens-and-airborne-allergens-in-relation-to-biomarkers-of-type-2-inflammation-in-asthma
#5
A Patelis, K Alving, R Middelveld, A James, J Ono, S Ohta, K Izuhara, M P Borres, B Forsberg, C Janson, A Malinovschi
BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. OBJECTIVE: To investigate the relation between IgE sensitisation and several type 2 inflammation biomarkers in adult asthmatics. METHODS: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study...
May 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29729518/short-term-effects-of-physical-activity-air-pollution-and-their-interaction-on-the-cardiovascular-and-respiratory-system
#6
Michelle Laeremans, Evi Dons, Ione Avila-Palencia, Glòria Carrasco-Turigas, Juan Pablo Orjuela, Esther Anaya, Tom Cole-Hunter, Audrey de Nazelle, Mark Nieuwenhuijsen, Arnout Standaert, Martine Van Poppel, Patrick De Boever, Luc Int Panis
Physical activity (PA) in urban environments may lead to increased inhalation of air pollutants. As PA and air pollution (AP) have respectively beneficial and detrimental effects on the cardiorespiratory system, the responses to these exposures can interact. Therefore, we assessed the short-term effects of PA, AP and their interaction on a set of subclinical cardiovascular and respiratory outcomes in a panel of healthy adults: heart rate variability (HRV), retinal vessel diameters, lung function and fractional exhaled nitric oxide (FeNO)...
May 2, 2018: Environment International
https://www.readbyqxmd.com/read/29719507/breathomics-for-assessing-the-effects-of-treatment-and-withdrawal-with-inhaled-beclomethasone-formoterol-in-patients-with-copd
#7
Paolo Montuschi, Giuseppe Santini, Nadia Mores, Alessia Vignoli, Francesco Macagno, Rugia Shoreh, Leonardo Tenori, Gina Zini, Leonello Fuso, Chiara Mondino, Corrado Di Natale, Arnaldo D'Amico, Claudio Luchinat, Peter J Barnes, Tim Higenbottam
Background: Prospective pharmacological studies on breathomics profiles in COPD patients have not been previously reported. We assessed the effects of treatment and withdrawal of an extrafine inhaled corticosteroid (ICS)-long-acting β2 -agonist (LABA) fixed dose combination (FDC) using a multidimensional classification model including breathomics. Methods: A pilot, proof-of-concept, pharmacological study was undertaken in 14 COPD patients on maintenance treatment with inhaled fluticasone propionate/salmeterol (500/50 μg b...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29714162/exhaled-nitric-oxide-is-not-a-biomarker-for-pulmonary-tuberculosis
#8
José W López, Maria-Cristina I Loader, Dan Smith, Dan Pastorius, Marjory Bravard, Luz Caviedes, Karina M Romero, Taryn Clark, William Checkley, Eduardo Ticona, Jon S Friedland, Robert H Gilman
To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60)...
April 30, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29692617/both-fractional-exhaled-nitric-oxide-and-sputum-eosinophil-were-associated-with-uncontrolled-asthma
#9
Jie Gao, Zhaocheng Chen, Xiang Jie, Ruihua Ye, Feng Wu
Background: Sputum eosinophil and fractional exhaled nitric oxide (FeNO), noninvasive biomarkers of local eosinophilic airway inflammation, can be used to assess asthma outcome. Nevertheless, the clinical application of the association between FeNO and sputum eosinophil is controversial. The aim of the study was to investigate the predictive relationship between FeNO and sputum eosinophil in uncontrolled asthmatic patients and the correlation between sputum eosinophil and FeNO in bronchial reversibility and bronchial hyperresponsiveness (BHR)...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29690880/abnormal-pulmonary-function-tests-predict-the-development-of-radiation-induced-pneumonitis-in-advanced-non-small-cell-lung-cancer
#10
L Torre-Bouscoulet, W R Muñoz-Montaño, D Martínez-Briseño, F J Lozano-Ruiz, R Fernández-Plata, J A Beck-Magaña, C García-Sancho, A Guzmán-Barragán, E Vergara, M Blake-Cerda, L Gochicoa-Rangel, F Maldonado, M Arroyo-Hernández, O Arrieta
BACKGROUND: Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predict RP in non-small cell lung cancer (NSCLC) patients. METHODS: A prospective multi-institutional study was conducted with locally advanced and oligometastatic NSCLC patients...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29668530/cardiorespiratory-effects-of-air-pollution-in-a-panel-study-of-winter-outdoor-physical-activity-in-older-adults
#11
David M Stieb, Robin Shutt, Lisa Marie Kauri, Gail Roth, Mieczyslaw Szyszkowicz, Nina A Dobbin, Li Chen, Marc Rigden, Keith Van Ryswyk, Ryan Kulka, Branka Jovic, Marie Mulholland, Martin S Green, Ling Liu, Guillaume Pelletier, Scott A Weichenthal, Robert E Dales
OBJECTIVE: The aim of this study was to assess cardiorespiratory effects of air pollution in older adults exercising outdoors in winter. METHODS: Adults 55 years of age and older completed daily measurements of blood pressure, peak expiratory flow and oximetry, and weekly measurements of heart rate variability, endothelial function, spirometry, fraction of exhaled nitric oxide and urinary oxidative stress markers, before and after outdoor exercise, for 10 weeks...
April 17, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29650557/sputum-proteomics-and-airway-cell-transcripts-of-current-and-ex-smokers-with-severe-asthma-in-u-biopred-an-exploratory-analysis
#12
Kentaro Takahashi, Stelios Pavlidis, Francois Ng Kee Kwong, Uruj Hoda, Christos Rossios, Kai Sun, Matthew Loza, Fred Baribaud, Pascal Chanez, Steve J Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Sven-Eric Dahlen, N Krug, Thomas Sandstrom, Dominic E Shaw, Rene Lutter, Per Bakke, Louise J Fleming, Peter H Howarth, Massimo Caruso, Ana R Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Ratko Djukanovic, Peter J Sterk, Yike Guo, Ian M Adcock, Kian Fan Chung
Background: Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes. Methods: The U-BIOPRED severe asthma patients containing current-smokers (CSA), ex-smokers (ESA), non-smokers (NSA) and healthy non-smokers (NH) was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29648484/serum-periostin-levels-serve-as-a-biomarker-for-both-eosinophilic-airway-inflammation-and-fixed-airflow-limitation-in-well-controlled-asthmatics
#13
Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-Ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara, Itsuo Iwamoto
OBJECTIVE: Periostin, a matricellular protein, is produced from airway epithelial cells and lung fibroblasts by IL-13. It has been suggested that periostin is involved in allergic inflammation and fibrosis. However, the usefulness of serum periostin measurement in the assessment of airway inflammation and remodeling and management of asthmatic patients is still debated. We aimed to determine whether serum periostin levels reflect eosinophilic airway inflammation and airway remodeling in asthma...
April 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29644894/decreased-epithelial-and-sputum-mir-221-3p-associates-with-airway-eosinophilic-inflammation-and-cxcl17-expression-in-asthma
#14
Kan Zhang, Yuxia Liang, Yuchen Feng, Wenliang Wu, Huilan Zhang, Jianguo He, Qinghua Hu, Jian-Ping Zhao, Yongjian Xu, Zheng Liu, Guohua Zhen
Airway eosinophilic inflammation is a key feature of type 2-high asthma. The role of epithelial miRNA in airway eosinophilic inflammation remains unclear. We examined the expression of miR-221-3p in bronchial brushings, induced sputum and plasma from 77 symptomatic, recently diagnosed steroid-naïve subjects with asthma and 36 healthy controls by quantitative PCR, and analyzed the correlation between miR-221-3p expression and airway eosinophilia. We found that epithelial, sputum and plasma miR-221-3p expression was significantly decreased in subjects with asthma...
April 12, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29609706/gestational-obstructive-sleep-apnea-biomarker-screening-models-and-lack-of-postpartum-resolution
#15
Linda M Street, Carol A Aschenbrenner, Timothy T Houle, Clark W Pinyan, James C Eisenach
STUDY OBJECTIVES: To measure prevalence and severity of third trimester obstructive sleep apnea and evaluate postpartum resolution. To assess a novel biomarker for screening for obstructive sleep apnea in pregnancy. METHODS: This prospective observational study was performed at Wake Forest School of Medicine obstetrics clinics between April 2014 and December 2015. Fractional exhaled nitric oxide measurements and sleep studies were obtained and compared at 32 0/7 to 35 6/7 weeks gestation and postpartum...
April 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29575336/simultaneously-elevated-feno-and-blood-eosinophils-relate-to-asthma-morbidity-in-asthmatics-from-nhanes-2007-12
#16
Ida Mogensen, Kjell Alving, Tiago Jacinto, João A Fonseca, Christer Janson, Andrei Malinovschi
BACKGROUND: Fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count are biomarkers for type 2 inflammation. However, they signal different inflammatory pathways. Simultaneously elevated, they are related to more asthma events in a general population and among younger asthmatics. OBJECTIVE: To investigate if simultaneously elevated FeNO and B-Eos relate to asthma outcomes and lung function among subjects with asthma at a wide age span, and how different cut offs for the markers affect these relations...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575179/sensitisation-to-minor-cat-allergen-components-is-associated-with-type-2-biomarkers-in-young-asthmatics
#17
N Tsolakis, A Malinovschi, L Nordvall, L Mattsson, J Lidholm, C Pedroletti, C Janson, M P Borres, K Alving
BACKGROUND: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisation vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied. OBJECTIVE: To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitised to furry animals. METHODS: Patients with asthma (age 10-35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins)...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29538544/between-occasion-repeatability-of-fractional-exhaled-nitric-oxide-measurements-in-children
#18
Kamil Barański, Jan E Zejda
The aim of the study was to assess short-term repeatability of measurements of fractional exhaled nitric oxide (FENO) and its correlates in children in the 6- to 9-year age bracket participating in a respiratory epidemiological survey. FENO was measured in two sessions one week apart in 101 children. Participants were divided into three groups: asymptomatic (n = 76); symptomatic (n = 14); and asthma (n = 11). Absolute and relative differences between the measurements, as well as concordance correlation coefficients, were used in order to assess repeatability...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29524536/managing-asthma-in-pregnancy-map-trial-feno-levels-and-childhood-asthma
#19
Matthew Morten, Adam Collison, Vanessa E Murphy, Daniel Barker, Christopher Oldmeadow, John Attia, Joseph Meredith, Heather Powell, Paul D Robinson, Peter D Sly, Peter G Gibson, Joerg Mattes
BACKGROUND: The single-center double-blind, randomized controlled Managing Asthma in Pregnancy (MAP) trial in Newcastle, Australia, compared a treatment algorithm using the fraction of exhaled nitric oxide (FENO) in combination with asthma symptoms (FENO group) against a treatment algorithm using clinical symptoms only (clinical group) in pregnant asthmatic women (Australian New Zealand Clinical Trials Registry, no. 12607000561482). The primary outcome was a 50% reduction in asthma exacerbations during pregnancy in the FENO group...
March 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29512366/clinical-course-and-factors-associated-with-asthma-control-in-children-under-control-based-asthma-management-a-prospective-study
#20
Qi Gao, Huijie Huang, Kang Zhu, Xiaoying Liu, Xiaoling Hou, Hui Guan, Yongge Liu, Deli Xin, Li Xiang, Kunling Shen, Xin Ni
In the current study, we sought to track the clinical course of children under control-based asthma management and focused on respiratory pathogens monitoring. We prospectively explored influencing factors for asthma control. 121 children with uncontrolled asthma between 3-14 years of age were recruited. Common respiratory pathogens were detected with pharyngeal swabs and serum aeroallergen-specific IgE was measured. Numeric asthma control scores, airway resistance and fractional concentrations of exhaled nitric oxide (FENO) were evaluated...
February 2018: Iranian Journal of Allergy, Asthma, and Immunology
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