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https://www.readbyqxmd.com/read/29790837/modulation-of-spinal-motor-networks-by-astrocyte-derived-adenosine-is-dependent-on-d1-like-dopamine-receptor-signalling
#1
David Acton, Matthew J Broadhead, Gareth Brian Miles
Astrocytes modulate many neuronal networks, including spinal networks responsible for the generation of locomotor behaviour. Astrocytic modulation of spinal motor circuits involves release of ATP from astrocytes, hydrolysation of ATP to adenosine, and subsequent activation of neuronal A1 adenosine receptors (A1Rs). The net effect of this pathway is a reduction in the frequency of locomotor-related activity. Recently, it was proposed that A1Rs modulate burst frequency by blocking the D1-like dopamine receptor (D1LR) signalling pathway; however, adenosine also modulates ventral horn circuits by dopamine-independent pathways...
May 23, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29733365/the-associations-of-gender-with-social-participation-of-burn-survivors-a-life-impact-burn-recovery-evaluation-profile-study
#2
Benjamin Levi, Casey T Kraft, Gabriel D Shapiro, Nhi-Ha T Trinh, Emily C Dore, James Jeng, Austin F Lee, Amy Acton, Molly Marino, Alan Jette, Elizabeth A Armstrong, Jeffrey C Schneider, Lewis E Kazis, Colleen M Ryan
Burn injury can be debilitating and affect survivors' quality of life in a profound fashion. Burn injury may also lead to serious psychosocial challenges that have not been adequately studied and addressed. Specifically, there has been limited research into the associations of burn injury on community reintegration based on gender. This work analyzed data from 601 burn survivors who completed field testing of a new measure of social participation for burn survivors, the Life Impact Burn Recovery Evaluation (LIBRE) Profile...
May 4, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29724252/synthetic-versus-autologous-reconstruction-syn-var-of-the-medial-patellofemoral-ligament-a-study-protocol-for-a-randomised-controlled-trial
#3
Adam Tucker, Sam McMahon, Bronwyn McArdle, Bridgeen Rutherford, Danny Acton
BACKGROUND: Recurrent patellar instability incidence is 5.8/100,000 population, and recurrent dislocations are reported in the range of 15-80%. Recurrent instability is multifactorial and can be associated with disorder of limb alignment, osseous development, congruity of the patella in the trochlea and soft tissue static and dynamic constraints. The multifactorial aetiology makes management challenging, and a lack studies in a heterogeneous population with robust clinical outcomes compounds this further...
May 3, 2018: Trials
https://www.readbyqxmd.com/read/29723236/health-management-and-pattern-analysis-of-daily-living-activities-of-people-with-dementia-using-in-home-sensors-and-machine-learning-techniques
#4
Shirin Enshaeifar, Ahmed Zoha, Andreas Markides, Severin Skillman, Sahr Thomas Acton, Tarek Elsaleh, Masoud Hassanpour, Alireza Ahrabian, Mark Kenny, Stuart Klein, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi
The number of people diagnosed with dementia is expected to rise in the coming years. Given that there is currently no definite cure for dementia and the cost of care for this condition soars dramatically, slowing the decline and maintaining independent living are important goals for supporting people with dementia. This paper discusses a study that is called Technology Integrated Health Management (TIHM). TIHM is a technology assisted monitoring system that uses Internet of Things (IoT) enabled solutions for continuous monitoring of people with dementia in their own homes...
2018: PloS One
https://www.readbyqxmd.com/read/29651772/monitoring-neurointerventional-radiation-doses-using-dose-tracking-software-implications-for-the-establishment-of-local-diagnostic-reference-levels
#5
Holly Acton, Karl James, Richard G Kavanagh, Colm O'Tuathaigh, Deirdre Moloney, Gerald Wyse, Noel Fanning, Michael Maher, Owen J O'Connor
OBJECTIVES: There is potential for high radiation exposure during neurointerventional procedures. Increasing regulatory requirements mandate dose monitoring of patients and staff, and justification of high levels of radiation exposure. This paper demonstrates the potential to use radiation dose-tracking software to establish local diagnostic reference levels. METHODS: Consecutive neurointerventional procedures, performed in a single institution within a one-year period, were retrospectively studied...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29643186/peripherally-derived-macrophages-can-engraft-the-brain-independent-of-irradiation-and-maintain-an-identity-distinct-from-microglia
#6
James C Cronk, Anthony J Filiano, Antoine Louveau, Ioana Marin, Rachel Marsh, Emily Ji, Dylan H Goldman, Igor Smirnov, Nicholas Geraci, Scott Acton, Christopher C Overall, Jonathan Kipnis
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during central nervous system (CNS) inflammation. It was initially suggested that these engrafting cells were newly derived microglia and that irradiation was essential for engraftment to occur. However, it remains unclear whether brain-engrafting macrophages (beMφs) acquire a unique phenotype in the brain, whether long-term engraftment may occur without irradiation, and whether brain function is affected by the engrafted cells...
April 11, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29514225/consumer-perceptions-of-specific-design-characteristics-for-front-of-package-nutrition-labels
#7
R B Acton, L Vanderlee, C A Roberto, D Hammond
An increasing number of countries are developing front-of-package (FOP) labels; however, there is limited evidence examining the impact of specific design characteristics for these labels. The current study investigated consumer perceptions of several FOP label design characteristics, including potential differences among sociodemographic sub-groups. Two hundred and thirty-four participants aged 16 years or older completed nine label rating tasks on a laptop at a local shopping mall in Canada. The rating tasks asked participants to rate five primary design characteristics (border, background presence, background colour, 'caution' symbol and government attribution) on their noticeability, readability, believability and likelihood of changing their beverage choice...
April 1, 2018: Health Education Research
https://www.readbyqxmd.com/read/29454525/radial-umbilical-dermatofasciolysis-to-invert-the-skin-following-umbilical-herniorrhaphy
#8
Emma J Cordes, Melanie LaPlant, Daniel A Saltzman, Robert D Acton, Bradley J Segura, Donavon J Hess
BACKGROUND: Umbilical hernia is a common congenital anomaly, and can result in the appearance of a protuberant umbilicus. In select cases, inversion of the umbilical skin can be impaired by the presence of thickened dermis or fascial remnants of the umbilical stalk. DESCRIPTION OF OPERATIVE TECHNIQUE: After umbilical herniorrhaphy, the skin is everted over the left index finger and radial partial thickness incisions in the fascia and dermis of the undersurface of the umbilicus...
February 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29432652/osteonecrosis-of-the-jaws-a-14-year-retrospective-survey-of-hospital-admissions
#9
K McGowan, S Ivanovski, C Acton
BACKGROUND: Osteonecrosis of the jaw (ONJ) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication-related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis (ORN), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures. METHODS: Medical records at the Royal Brisbane and Women's Hospital, Gold Coast University Hospital and Robina Hospital were reviewed to identify patients diagnosed with MRONJ and ORN between January 2003 and May 2017...
February 12, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29427260/feasibility-of-analyzing-dna-copy-number-variation-in-breast-cancer-tumor-specimens-from-1950-to-2010-how-old-is-too-old
#10
Nancy Krieger, Sheida Nabavi, Pamela D Waterman, Ninah S Achacoso, Luana Acton, Stuart J Schnitt, Laurel A Habel
PURPOSE: The purpose of the study was to assess the feasibility of quantifying long-term trends in breast tumor DNA copy number variation (CNV) profiles. METHODS: We evaluated CNV profiles in formalin-fixed paraffin-embedded (FFPE) tumor specimens from 30 randomly selected Kaiser Permanente Northern California health plan women members diagnosed with breast cancer from 1950 to 2010. Assays were conducted for five cases per decade who had available tumor blocks and pathology reports...
March 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29421525/impact-of-calcium-sensitive-dyes-on-the-beating-properties-and-pharmacological-responses-of-human-ips-derived-cardiomyocytes-using-the-calcium-transient-assay
#11
Ivan Kopljar, An N Hermans, Ard Teisman, David J Gallacher, Hua Rong Lu
INTRODUCTION: Calcium-based screening of hiPS-CMs is a useful preclinical safety evaluation platform with the ability to generate robust signals that facilitates high-throughput screening and data analysis. However, due to the potential inherent toxicities, it is important to understand potential effects of different calcium-sensitive dyes on the hiPS-CMs model. METHODS: We compared three calcium-sensitive fluorescence dyes (Cal520, ACTOne and Calcium 5) for their impact on the variability, the beating properties and the pharmacological responses of hiPS-CMs using the Hamamatsu FDSS/μCell imaging platform...
May 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29398281/neurocognitive-outcomes-after-heart-transplantation-in-early-childhood
#12
Simon Urschel, Gwen Y Bond, Irina A Dinu, Fahime Moradi, Jennifer Conway, Gonzalo Garcia-Guerra, Bryan V Acton, Ari R Joffe, Mohammed AlAklabi, Ivan M Rebeyka, Charlene M T Robertson
BACKGROUND: Children requiring heart transplantation (HTx) for congenital heart disease (CHD) or failing anatomically normal hearts (CMP) face different challenges pre-HTx. We compared the neurocognitive capabilities in pre-school-age children receiving HTx for CHD vs CMP and determined factors predicting outcomes. METHODS: Data were collected within a prospective multi-provincial project from children who underwent HTx ≤4 years of age between 1999 and 2011. At age 54 ± 3 months, we obtained scores from the Wechsler Preschool and Primary Scales of Intelligence for full-scale intelligence quotient (FSIQ) verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ), and from the Beery-Buktenica Developmental Test for visual-motor integration (VMI)...
December 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29295990/obligatory-and-facilitative-allelic-variation-in-the-dna-methylome-within-common-disease-associated-loci
#13
Christopher G Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G Hysi, Jun Wang, Timothy D Spector
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify DNA methylation variability between GWAS-SNP risk and non-risk haplotypes. In three subsets comprising 3128 MeDIP-seq peripheral-blood DNA methylomes, we find 7173 consistent and functionally enriched Differentially Methylated Regions...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29273918/a-review-of-atypical-subtrochanteric-femoral-fractures-in-northern-ireland-between-2010-and-2014
#14
K J Donnelly, A Tucker, B Kerr, S McDonald, D S O'Longain, J D Acton
The term atypical femoral fractures most commonly occur in the subtrochanteric area. Concerns exist regarding the role of bisphosphonate treatment in their aetiology. Which surgical intervention provides the best outcome remains contentious. We reviewed all atypical subtrochanteric femoral fractures treated in Northern Ireland over 5 years, specifically investigating incidence, prodromal symptoms, association with bisphosphonates and optimal fixation methods. All subtrochanteric fractures treated in the region were identified and reviewed for atypical features...
December 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29230481/biological-responses-in-brook-trout-salvelinus-fontinalis-caged-downstream-from-municipal-wastewater-treatment-plants-in-the-credit-river-on-canada
#15
Stephen McGovarin, Tamanna Sultana, Chris Metcalfe
To determine whether discharges of contaminants from municipal wastewater treatment plants (WWTPs) may be contributing to the decline in populations of brook trout (Salvelinus fontinalis) in the watershed of the Credit River in ON, Canada, we caged juvenile brook trout upstream and downstream of the WWTPs of the small communities of Acton and Orangeville. Levels of vitellogenin were significantly elevated in liver tissue of trout caged downstream of both WWTPs, indicating exposure to estrogenic substances. Levels of thiobarbituric acid reactive substances indicative of oxidation of lipids were elevated in the gill tissue of brook trout caged downstream of the Orangeville WWTP, and levels of total glutathione were significantly lower in the gills of brook trout caged downstream of the Acton WWTP...
January 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29183751/impact-of-work-related-burn-injury-on-social-reintegration-outcomes-a-life-impact-burn-recovery-evaluation-libre-study
#16
Jeffrey C Schneider, Vivian L Shie, Leda F Espinoza, Gabriel D Shapiro, Austin Lee, Amy Acton, Molly Marino, Alan Jette, Lewis E Kazis, Colleen M Ryan
OBJECTIVE: To examine differences in long-term social reintegration outcomes for burn survivors with and without work-related injuries. DESIGN: Cross-sectional survey. SETTING: Community-dwelling burn survivors. PARTICIPANTS: Burn survivors (N=601) aged ≥18 years with injuries to ≥5% total body surface area or burns to critical areas (hands, feet, face, or genitals). INTERVENTIONS: Not applicable...
November 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29174772/leaders-by-example-best-practices-and-advice-on-establishing-a-state-of-the-art-surgical-simulation-center-that-optimizes-available-resources
#17
A K Gardner, E M Ritter, B J Dunkin, D S Smink, J N Lau, J T Paige, R Phitayakorn, R D Acton, D Stefanidis, D W Gee
BACKGROUND: The role of simulation-based education continues to expand exponentially. To excel in this environment as a surgical simulation leader requires unique knowledge, skills, and abilities that are different from those used in traditional clinically-based education. METHODS: Leaders in surgical simulation were invited to participate as discussants in a pre-conference course offered by the Association for Surgical Education. Highlights from their discussions were recorded...
February 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29146460/the-impact-of-price-and-nutrition-labelling-on-sugary-drink-purchases-results-from-an-experimental-marketplace-study
#18
Rachel B Acton, David Hammond
OBJECTIVE: To examine the effect of front-of-package (FOP) nutrition labelling and sugary drink taxation on consumer beverage purchases. METHODS: A total of 675 respondents aged 16 years and older participated in an experimental marketplace study using a 4 × 5 within-between group design. Participants were randomised to one of four labelling conditions (no label; star rating; high sugar symbol; health warning) and completed five within-subject purchase tasks...
February 1, 2018: Appetite
https://www.readbyqxmd.com/read/29136614/impact-of-early-infant-growth-duration-of-breastfeeding-and-maternal-factors-on-total-body-fat-mass-and-visceral-fat-at-3-and-6-months-of-age
#19
Laura M Breij, Marieke Abrahamse-Berkeveld, Dennis Acton, Emanuella De Lucia Rolfe, Ken K Ong, Anita C S Hokken-Koelega
BACKGROUND: Accelerated gain in fat mass in the first months of life is considered to be a risk factor for adult diseases, given the tracking of infancy fat mass into adulthood. Our objective was to assess the influence of early growth, type of feeding and maternal variables on fat mass in early life. METHODS: In 300 healthy term infants, we longitudinally measured fat mass percentage (FM%) by air-displacement-plethysmography at 1, 3, and 6 months and abdominal visceral and subcutaneous fat measured by ultrasound at 3 and 6 months...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29097179/long-term-social-reintegration-outcomes-for-burn-survivors-with-and-without-peer-support-attendance-a-life-impact-burn-recovery-evaluation-libre-study
#20
Brian Grieve, Gabriel D Shapiro, Lucy Wibbenmeyer, Amy Acton, Austin Lee, Molly Marino, Alan Jette, Jeffrey C Schneider, Lewis E Kazis, Colleen M Ryan
OBJECTIVE: To examine differences in long-term social reintegration outcomes for burn survivors with and without peer support attendance. DESIGN: Cross-sectional survey. SETTING: Community-dwelling burn survivors. PARTICIPANTS: Burn survivors (N=601) aged ≥18 years with injuries to ≥5% total body surface area (TBSA) or burns to critical areas (hands, feet, face, or genitals). INTERVENTIONS: Not applicable...
October 31, 2017: Archives of Physical Medicine and Rehabilitation
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