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https://www.readbyqxmd.com/read/28422122/infant-milk-fat-droplet-size-and-coating-affect-postprandial-responses-in-healthy-adult-men-a-proof-of-concept-study
#1
S Baumgartner, B J M van de Heijning, D Acton, R P Mensink
BACKGROUND/OBJECTIVES: Fat droplets in human milk (HM) are larger and surrounded by a phospholipid membrane compared with infant milk formulas (IMF). Since the physical structure of fat droplets might affect digestion and postprandial metabolism, an IMF was developed more mimicking HM lipid structure than current IMF. SUBJECTS/METHODS: A randomised, double-blind, crossover study was performed in 29 fasted healthy men (aged 18-25 years, BMI: 18-25 kg/m(2)) to compare 5-hour postprandial responses after consumption of an experimental IMF (Concept, Nuturis) with a current IMF (Control)...
April 19, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28422000/fibromyalgia-in-300-adult-index-patients-with-primary-immunodeficiency
#2
James C Barton, Luigi F Bertoli, Jackson C Barton, Ronald T Acton
OBJECTIVES: We sought to determine the prevalence and clinical and laboratory associations of fibromyalgia in adults with primary immunodeficiency (immunoglobulin (Ig) G subclass deficiency (IgGSD) and common variable immunodeficiency (CVID). METHODS: We performed a retrospective analysis of these observations in 300 non-Hispanic white adult index patients with recurrent/severe respiratory tract infections and IgGSD or CVID: age; sex; IgGSD; fibromyalgia; chronic fatigue; autoimmune conditions (ACs); interstitial cystitis (IC); diabetes; body mass index; serum Ig isotypes; blood lymphocytes and subsets; and human leukocyte antigen (HLA)-A and -B types and haplotypes...
April 19, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28401111/added-sugar-in-the-packaged-foods-and-beverages-available-at-a-major-canadian-retailer-in-2015-a-descriptive-analysis
#3
Rachel B Acton, Lana Vanderlee, Erin P Hobin, David Hammond
BACKGROUND: Excess consumption of added sugars has been associated with a variety of health problems, but there is little information available characterizing added sugar in the Canadian food supply. This study examined the presence and types of added sugars in the packaged food and beverage products available at a major Canadian grocery retailer. METHODS: We searched the ingredients lists of over 40 000 packaged food products available for sale in March 2015 for a variety of added sugar terms...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28368917/community-reintegration
#4
Radha K Holavanahalli, Karen Badger, Amy Acton
No abstract text is available yet for this article.
May 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28346300/the-burn-survivor-perspective
#5
Amy Acton, Karen Badger, John O'Leary
No abstract text is available yet for this article.
May 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28345217/fatigue-and-training-of-obstetrics-and-gynaecology-trainees-in-australia-and-new-zealand
#6
Paige E Tucker, Paul A Cohen, Max K Bulsara, Jade Acton
BACKGROUND: Several studies have linked doctor fatigue with adverse patient events and an increase in risk to doctors' personal safety and wellbeing. The present study assesses the rostering structure of Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) trainees and its association with trainees' reported fatigue levels, training opportunities and wellbeing, which were secondary outcomes of a larger study of trainee working hours which has been separately reported...
March 26, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28341901/hypoplastic-left-heart-syndrome-is-not-associated-with-worse-clinical-or-neurodevelopmental-outcomes-than-other-cardiac-pathologies-after-the-norwood-sano-operation
#7
Billie-Jean Martin, I De Villiers Jonker, Ari R Joffe, Gwen Y Bond, Bryan V Acton, David B Ross, Charlene M T Robertson, Ivan M Rebeyka, Joseph Atallah
There is evidence to suggest that patients undergoing a Norwood for non-HLHS anatomy may have lower mortality than classic HLHS, but differences in neurodevelopmental outcome have not been assessed. Our objective was to compare survival and neurodevelopmental outcome during the same surgical era in a large, well-described cohort. All subjects who underwent a Norwood-Sano operation between 2005 and 2014 were included. Follow-up clinical, neurological, and developmental data were obtained from the Western Canadian Complex Pediatric Therapies Follow-up Program database...
March 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28331855/diabetes-in-hfe-hemochromatosis
#8
REVIEW
James C Barton, Ronald T Acton
Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28299774/working-hours-of-obstetrics-and-gynaecology-trainees-in-australia-and-new-zealand
#9
Jade Acton, Paige E Tucker, Max K Bulsara, Paul A Cohen
BACKGROUND: The importance of doctors' working hours has gained significant attention with evidence suggesting long hours and fatigue may compromise the safety and wellbeing of both patients and doctors. This study aims to quantify the working hours of The Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) specialist trainees in order to better inform discussions of working hours and safety within our region. METHODS: An anonymous, online survey of RANZCOG trainees was conducted...
March 15, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28294687/twenty-two-years-of-u-s-meat-and-poultry-product-recalls-implications-for-food-safety-and-food-waste
#10
Acton Gorton, Matthew J Stasiewicz
The U.S. Department of Agriculture, Food Safety and Inspection Service maintains a recall case archive of meat and poultry product recalls from 1994 to the present. In this study, we collected all recall records from 1994 to 2015 and extracted the recall date, meat or poultry species implicated, reason for recall, recall class, and pounds of product recalled and recovered. Of a total of 1,515 records analyzed, the top three reasons for recall were contamination with Listeria, undeclared allergens, and Shiga toxin-producing Escherichia coli ...
March 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28265415/metabolic-improvements-following-roux-en-y-surgery-assessed-by-solid-meal-test-in-subjects-with-short-duration-type-2-diabetes
#11
Sudha S Shankar, Lori A Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J Acton, RoseMarie Jones, Samer G Mattar, Deborah L Miller, Lea Petry, Chan R Beals, S Aubrey Stoch, David E Kelley, Robert V Considine
BACKGROUND: Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance tests (MMTT). Few studies have evaluated the glycemic and hormonal response to a solid mixed meal in subjects with diabetes prior to, and within the first month following RYGB. METHODS: Seventeen women with type 2 diabetes of less than 5 years duration participated...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28202572/differential-regulation-of-nmda-receptors-by-d-serine-and-glycine-in-mammalian-spinal-locomotor-networks
#12
David Acton, Gareth Brian Miles
Activation of N-methyl-D-aspartate receptors (NMDARs) requires the binding of a co-agonist, either D-serine or glycine, in addition to glutamate. Changes in occupancy of the co-agonist binding site are proposed to modulate neural networks including those controlling swimming in frog tadpoles. Here, we characterize regulation of the NMDAR co-agonist binding site in mammalian spinal locomotor networks. Blockade of NMDARs by D(-)-2-amino-5-phosphonopentanoic acid (D-APV) or 5,7-dichlorokynurenic acid reduced the frequency and amplitude of pharmacologically induced locomotor-related activity recorded from the ventral roots of spinal-cord preparations from neonatal mice...
February 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28175017/p219-inflammatory-bowel-disease-in-children-is-a-challenging-diagnosis-when-overlaps-with-coeliac-disease
#13
A Zambrano Perez, R Shergill-Bonner, F Kiparissi, N Acton, K Lindley, N Shah, M Baycheva
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172976/p591-therapeutic-drug-monitoring-in-paediatric-inflammatory-bowel-disease-on-maintenance-infliximab-and-adalimumab-treatment-improves-clinical-remission-with-a-proactive-approach
#14
S Chadokufa, S Sider, B Huggett, T Sawney, N Shah, M Baycheva, A Zambrano Perez, N Acton, F Kiparissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172769/p707-paediatric-ibd-patients-do-not-meet-the-daily-recommendations-of-vitamin-d-and-calcium-intake-survey-based-analysis-in-a-tertiary-centre
#15
R Shergill-Bonner, A Zambrano Perez, N Acton, S Chadokufa, B Huggett, F Kiparissi, M Baycheva, N Shah, S Sider
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172761/p479-shifting-the-shunters-in-a-paediatric-inflammatory-bowel-disease-population-thiopurine-dose-splitting-versus-allopurinol-and-thiopurine-co-therapy
#16
S Chadokufa, M Baycheva, T Sawney, N Acton, S Sider, N Shah, B Huggett, R Dziubak, F Kiparrissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28066922/x-ray-crystal-structure-of-the-n-terminal-region-of-moloney-murine-leukemia-virus-integrase-and-its-implications-for-viral-dna-recognition
#17
Rongjin Guan, Sriram Aiyer, Marie L Cote, Rong Xiao, Mei Jiang, Thomas B Acton, Monica J Roth, Gaetano T Montelione
The retroviral integrase (IN) carries out the integration of a dsDNA copy of the viral genome into the host DNA, an essential step for viral replication. All IN proteins have three general domains, the N-terminal domain (NTD), the catalytic core domain, and the C-terminal domain. The NTD includes an HHCC zinc finger-like motif, which is conserved in all retroviral IN proteins. Two crystal structures of Moloney murine leukemia virus (M-MuLV) IN N-terminal region (NTR) constructs that both include an N-terminal extension domain (NED, residues 1-44) and an HHCC zinc-finger NTD (residues 45-105), in two crystal forms are reported...
April 2017: Proteins
https://www.readbyqxmd.com/read/28013361/bone-mass-and-strength-are-significantly-improved-in-mice-overexpressing-human-wnt16-in-osteocytes
#18
Imranul Alam, Austin M Reilly, Mohammed Alkhouli, Rita L Gerard-O'Riley, Charishma Kasipathi, Dana K Oakes, Weston B Wright, Dena Acton, Amie K McQueen, Bhavmik Patel, Kyung-Eun Lim, Alexander G Robling, Michael J Econs
Recently, we demonstrated that osteoblast-specific overexpression of human WNT16 increased both cortical and trabecular bone mass and structure in mice. To further identify the cell-specific role of Wnt16 in bone homeostasis, we created transgenic (TG) mice overexpressing human WNT16 in osteocytes using Dmp1 promoter (Dmp1-hWNT16 TG) on C57BL/6 (B6) background. We analyzed bone phenotypes and serum bone biomarkers, performed gene expression analysis and measured dynamic bone histomorphometry in Dmp1-hWNT16 TG and wild-type (WT) mice...
April 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28005411/a-mutation-in-the-dmp1-gene-alters-phosphate-responsiveness-in-mice
#19
Shoji Ichikawa, Rita L Gerard-O'Riley, Dena Acton, Amie K McQueen, Isabel E Strobel, Phillip C Witcher, Jian Q Feng, Michael J Econs
Mutations in the dentin matrix protein 1 (DMP1) gene cause autosomal recessive hypophosphatemic rickets (ARHR). Hypophosphatemia in ARHR results from increased circulating levels of the phosphaturic hormone, fibroblast growth factor 23 (FGF23). Similarly, elevated FGF23, caused by mutations in the PHEX gene, is responsible for the hypophosphatemia in X-linked hypophosphatemic rickets (XLH). Previously, we demonstrated that a Phex mutation in mice creates a lower set point for extracellular phosphate, where an increment in phosphorus further stimulates Fgf23 production to maintain low serum phosphorus levels...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/27930779/effect-of-a-home-visit-based-low-vision-rehabilitation-intervention-on-visual-function-outcomes-an-exploratory-randomized-controlled-trial
#20
Jennifer H Acton, Bablin Molik, Helen Court, Tom H Margrain
Purpose: To examine the effect of a home visit-based visual rehabilitation intervention on: (1) self-reported visual function and (2) depression, wellbeing, loneliness, adjustment to visual loss, and generic health-related quality of life. Methods: In an exploratory, assessor-masked, individually randomized, single-center controlled trial, 67 participants (age: 75.22 ± 16.21 years) with low vision were allocated either to receive the home visit-based visual rehabilitation intervention (n = 35) or to a waiting list control arm (n = 32)...
December 1, 2016: Investigative Ophthalmology & Visual Science
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