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https://www.readbyqxmd.com/read/27910316/measurement-of-the-deuterium-balmer-series-line-emission-on-east
#1
C R Wu, J Huang, W Gao, W Gao, Z Xu, J F Chang, Y M Hou, Z Jin, J C Xu, Y M Duan, P F Zhang, Y J Chen, L Zhang, Z W Wu, J G Li
Volume recombination plays an important role towards plasma detachment for magnetically confined fusion devices. High quantum number states of the Balmer series of deuterium are used to study recombination. On EAST (Experimental Advanced Superconducting Tokamak), two visible spectroscopic measurements are applied for the upper/lower divertor with 13 channels, respectively. Both systems are coupled with Princeton Instruments ProEM EMCCD 1024B camera: one is equipped on an Acton SP2750 spectrometer, which has a high spectral resolution ∼0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27905678/a-phase-i-ii-trial-of-at9283-a-selective-inhibitor-of-aurora-kinase-in-children-with-relapsed-or-refractory-acute-leukemia-challenges-to-run-early-phase-clinical-trials-for-children-with-leukemia
#2
B Vormoor, G J Veal, M J Griffin, A V Boddy, J Irving, L Minto, M Case, U Banerji, K E Swales, J R Tall, A S Moore, M Toguchi, G Acton, K Dyer, C Schwab, C J Harrison, J D Grainger, D Lancaster, P Kearns, D Hargrave, J Vormoor
Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27884391/basic-airway-skills-acquisition-using-the-american-college-of-surgeons-association-for-surgical-education-medical-student-simulation-based-surgical-skills-curriculum-initial-results
#3
Sydne Muratore, Michael Kim, Jaisa Olasky, Andre Campbell, Robert Acton
BACKGROUND: The ACS/ASE Medical Student Simulation-Based Skills Curriculum was developed to standardize medical student training. This study aims to evaluate the feasibility and validity of implementing the basic airway curriculum. METHODS: This single-center, prospective study of medical students participating in the basic airway module from 12/2014-3/2016 consisted of didactics, small-group practice, and testing in a simulated clinical scenario. Proficiency was determined by a checklist of skills (1-15), global score (1-5), and letter grade (NR-needs review, PS-proficient in simulation scenario, CP-proficient in clinical scenario)...
November 4, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27828837/development-of-a-conceptual-framework-to-measure-the-social-impact-of-burns
#4
Molly Marino, Marina Soley-Bori, Alan M Jette, Mary D Slavin, Colleen M Ryan, Jeffrey C Schneider, Linda Resnik, Amy Acton, Flor Amaya, Melinda Rossi, Rene Soria-Saucedo, Lewis E Kazis
Measuring community reintegration following burn injury is important to assess the efficacy of therapies designed to optimize recovery. This project aims to develop and validate a conceptual framework for understanding the social impact of burn injuries in adults. The framework is critical for developing the item banks used for a computerized adaptive test. We performed a comprehensive literature review and consulted with clinical experts and burn survivors about social life areas impacted by burn injury. Focus groups with burn survivors and clinicians were conducted to inform and validate the framework...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27822783/intraoperative-temperature-regulation-in-children-using-a-liquid-warming-garment
#5
Mariya E Skube, Robert D Acton, Victor S Koscheyev, Gloria R Leon, Daniel A Saltzman
PURPOSE: Children undergoing operative intervention while induced under general anesthesia are at risk for experiencing a significant decrease in core body temperature that can lead to adverse systemic effects. Given that the head contributes an estimated 18% of a child's body surface area, we theorized that a liquid-warming garment applied to the head could control a pediatric patient's core body temperature during surgical procedures. METHODS: Patients undergoing elective, non-cranial, general surgical procedures were enrolled in the study...
November 7, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27763846/the-efficacy-of-calorie-labelling-formats-on-pre-packaged-foods-an-experimental-study-among-adolescents-and-young-adults-in-canada
#6
Rachel B Acton, Lana Vanderlee, Christine White, David Hammond
OBJECTIVES: Several countries have proposed changes to calorie labelling on nutrition facts tables (NFTs) on pre-packaged foods. As most research to date has examined general use of NFTs, there is a lack of evidence to guide specific design changes to calorie information on labels. This study examined the efficacy of various calorie labelling formats on recall, comprehension, and consumer preferences for calorie information. METHODS: Experiments were conducted as part of an online survey with a national sample of 2,008 Canadians aged 16-24...
October 20, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27746321/phenotypic-severity-of-autosomal-dominant-osteopetrosis-type-ii-ado2-mice-on-different-genetic-backgrounds-recapitulates-the-features-of-human-disease
#7
Imranul Alam, Amie K McQueen, Dena Acton, Austin M Reilly, Rita L Gerard-O'Riley, Dana K Oakes, Charishma Kasipathi, Abigail Huffer, Weston B Wright, Michael J Econs
Autosomal dominant osteopetrosis type II (ADO2) is a heritable osteosclerotic bone disorder due to dysfunctional osteoclast activity. ADO2 is caused by missense mutations in the chloride channel 7 (CLCN7) gene characterized by osteosclerosis with multiple fractures. ADO2 can result in osteomyelitis, visual loss and bone marrow failure. Currently, there is no cure for ADO2, and until recently no appropriate animal model of ADO2 existed to understand better the pathogenesis of this disease and to test new therapies...
January 2017: Bone
https://www.readbyqxmd.com/read/27588683/automated-retinal-layer-segmentation-using-spectral-domain-optical-coherence-tomography-evaluation-of-inter-session-repeatability-and-agreement-between-devices
#8
Louise Terry, Nicola Cassels, Kelly Lu, Jennifer H Acton, Tom H Margrain, Rachel V North, James Fergusson, Nick White, Ashley Wood
Retinal and intra-retinal layer thicknesses are routinely generated from optical coherence tomography (OCT) images, but on-board software capabilities and image scaling assumptions are not consistent across devices. This study evaluates the device-independent Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) for automated intra-retinal layer segmentation and image scaling for three OCT systems. Healthy participants (n = 25) underwent macular volume scans using a Cirrus HD-OCT (Zeiss), 3D-OCT 1000 (Topcon), and a non-commercial long-wavelength (1040nm) OCT on two occasions...
2016: PloS One
https://www.readbyqxmd.com/read/27574973/effect-of-systemic-iron-overload-and-a-chelation-therapy-in-a-mouse-model-of-the-neurodegenerative-disease-hereditary-ferritinopathy
#9
Holly J Garringer, Jose M Irimia, Wei Li, Charles B Goodwin, Briana Richine, Anthony Acton, Rebecca J Chan, Munro Peacock, Barry B Muhoberac, Bernardino Ghetti, Ruben Vidal
Mutations in the ferritin light chain (FTL) gene cause the neurodegenerative disease neuroferritinopathy or hereditary ferritinopathy (HF). HF is characterized by a severe movement disorder and by the presence of nuclear and cytoplasmic iron-containing ferritin inclusion bodies (IBs) in glia and neurons throughout the central nervous system (CNS) and in tissues of multiple organ systems. Herein, using primary mouse embryonic fibroblasts from a mouse model of HF, we show significant intracellular accumulation of ferritin and an increase in susceptibility to oxidative damage when cells are exposed to iron...
2016: PloS One
https://www.readbyqxmd.com/read/27570242/management-of-giant-omphaloceles-a-systematic-review-of-methods-of-staged-surgical-vs-nonoperative-delayed-closure
#10
REVIEW
Brent Bauman, Daniel Stephens, Hannah Gershone, Connie Bongiorno, Erin Osterholm, Robert Acton, Donavon Hess, Daniel Saltzman, Bradley Segura
PURPOSE: Despite the numerous methods of closure for giant omphaloceles, uncertainty persists regarding the most effective option. Our purpose was to review the literature to clarify the current methods being used and to determine superiority of either staged surgical procedures or nonoperative delayed closure in order to recommend a standard of care for the management of the giant omphalocele. METHODS: Our initial database search resulted in 378 articles. After de-duplification and review, we requested 32 articles relevant to our topic that partially met our inclusion criteria...
October 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27514008/trends-in-the-characteristics-dose-limiting-toxicities-and-efficacy-of-phase-i-oncology-trials-the-cancer-research-uk-experience
#11
Han Hsi Wong, Claire Barton, Gary Acton, Robert McLeod, Sarah Halford
INTRODUCTION: Phase I oncology trials have evolved over the years, and these changes could have implications for future studies and patients. METHODS: Adult trials sponsored by Cancer Research UK Centre for Drug Development between 1995 and 2013 were analysed. Forty-nine trials were divided into two groups based on the starting date for recruitment: 1995-2003 (24 trials, n = 603) and 2004-2013 (25 trials, n = 750) for comparative purposes. RESULTS: From 1995-2003 to 2004-2013, there was a shift towards studying non-cytotoxic agents that are administered orally...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27445421/on-orbit-performance-and-calibration-of-the-soft-x-ray-telescope-on-yohkoh
#12
Loren W Acton
This paper documents details of the on-orbit performance, data problem solving, and calibration of the Soft X-ray Telescope (SXT) experiment on Yohkoh. This information is important to a full understanding of the strengths and weaknesses of the SXT data set. The paper begins with summaries of SXT calibration issues and how they have been addressed, operational anomalies experienced during the mission, and a brief discussion of the SXT optical train. The following section on the accuracy of Yohkoh pointing determination provides information important for alignment of SXT images with each other and with other solar data...
2016: Solar Physics
https://www.readbyqxmd.com/read/27389317/differences-in-the-anthropometry-of-asian-children-and-its-role-in-metabolic-health-in-later-life-a-narrative-review
#13
Leilani Muhardi, Marieke Abrahamse-Berkeveld, Dennis Acton, Eline M van der Beek
BACKGROUND: The increasing incidence of childhood obesity in Asia could be a reflection of early life programming in which environmental/nutritional challenges during pregnancy and first two years of life (the so-called first 1000 days) influence later health. OBJECTIVE OF NARRATIVE REVIEW: To assess differences/similarities of anthropometric measures in early life and their influences on metabolic health risk in later life among children in Asia. METHODS: Literature search for publication in English using selected key words from Medline (PubMed), Scopus, Science Direct and Google Scholar published from 1994 to October 2014...
July 4, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27380121/measuring-the-social-impact-of-burns-on-survivors
#14
Molly Marino, Marina Soley-Bori, Alan M Jette, Mary D Slavin, Colleen M Ryan, Jeffrey C Schneider, Amy Acton, Flor Amaya, Melinda Rossi, Rene Soria-Saucedo, Linda Resnik, Lewis E Kazis
Many burn survivors experience social challenges throughout their recovery. Measuring the social impact of a burn injury is important to identify opportunities for interventions. The aim of this study is to develop a pool of items addressing the social impact of burn injuries in adults to develop a self-reported measure using item response theory for development of a computerized adaptive test. The authors conducted a comprehensive literature review to identify preexisting items in other self-reported measures and used data from focus groups to create new items...
June 29, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27345083/runner-up-2016
#15
Maria Hughes, Claire Acton
No abstract text is available yet for this article.
June 23, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27302973/phenotypic-and-genotypic-characterisation-of-inflammatory-bowel-disease-presenting-before-the-age-of-2-years
#16
Jochen Kammermeier, Robert Dziubak, Matilde Pescarin, Suzanne Drury, Heather Godwin, Kate Reeve, Sibongile Chadokufa, Bonita Huggett, Sara Sider, Chela James, Nikki Acton, Elena Cernat, Marco Gasparetto, Gabi Noble-Jamieson, Fevronia Kiparissi, Mamoun Elawad, Phil L Beales, Neil J Sebire, Kimberly Gilmour, Holm H Uhlig, Chiara Bacchelli, Neil Shah
OBJECTIVES: Inflammatory bowel disease [IBD] presenting in early childhood is extremely rare. More recently, progress has been made to identify children with monogenic forms of IBD predominantly presenting very early in life. In this study, we describe the heterogeneous phenotypes and genotypes of patients with IBD presenting before the age of 2 years and establish phenotypic features associated with underlying monogenicity. METHODS: Phenotype data of 62 children with disease onset before the age of 2 years presenting over the past 20 years were reviewed...
June 14, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27295563/multimodality-peak-lctal-vital-signs-during-video-eeg-monitoring
#17
William O Tatum, Emily K Acton, Michael E Langston, Kirsten Yelvington, Cammi Bowman, Jerry J Shih, William P Cheshire
PURPOSE: To assess and compare peak, multimodal ictal vital signs (iVS) during epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES). METHODS: Between 4/1/2010 and 4/1/2011, 183 adults had video-EEG monitoring, with 96 consecutive patients meeting inclusion criteria. Heart rate (HR), oxygen saturation (SaO2), and blood pressure (BP) were obtained at baseline and during an ictus. The motor semiology of each ES and PNES was also assessed. Student t-test, Fischer's Test, Wilcoxon Test (p=<0...
August 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27238051/fibromyalgia-and-seizures
#18
William O Tatum, Michael E Langston, Emily K Acton
The purpose of this case-matched study was to determine how frequently fibromyalgia is associated with different paroxysmal neurological disorders and explore the utility of fibromyalgia as a predictor for the diagnosis of psychogenic non-epileptic seizures. The billing diagnosis codes of 1,730 new, non-selected patient encounters were reviewed over a three-year period for an epileptologist in a neurology clinic to identify all patients with historical diagnoses of fibromyalgia. The frequency with which epileptic seizures, psychogenic non-epileptic seizures, and physiological non-epileptic events were comorbid with fibromyalgia was assessed...
June 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27228289/phase-2-multicentre-trial-investigating-intermittent-and-continuous-dosing-schedules-of-the-poly-adp-ribose-polymerase-inhibitor-rucaparib-in-germline-brca-mutation-carriers-with-advanced-ovarian-and-breast-cancer
#19
Yvette Drew, Jonathan Ledermann, Geoff Hall, Daniel Rea, Ros Glasspool, Martin Highley, Gordon Jayson, Julieann Sludden, James Murray, David Jamieson, Sarah Halford, Gary Acton, Zoe Backholer, Raffaella Mangano, Alan Boddy, Nicola Curtin, Ruth Plummer
No abstract text is available yet for this article.
June 14, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27222351/use-of-fdss-%C3%AE-cell-imaging-platform-for-preclinical-cardiac-electrophysiology-safety-screening-of-compounds-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#20
Haoyu Zeng, Maria I Roman, Edward Lis, Armando Lagrutta, Frederick Sannajust
FDSS/μCell is a high-speed acquisition imaging platform (Hamamatsu Ltd., Hamamatsu, Japan) that allows for simultaneous high-throughput reading under controlled conditions. We evaluated the Ca(2+) transients or optical membrane potential changes of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) (iCells) in the presence or absence of 44 pharmacological agents known to interfere with cardiac ion channels (e.g., hERG, IKs, NaV1.5, CaV1.2). We tested two Ca(2+)-sensitive fluorescence dyes (Codex ACTOne® and EarlyTox®) and a membrane potential dye (FLIPR® membrane potential dye)...
September 2016: Journal of Pharmacological and Toxicological Methods
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