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https://www.readbyqxmd.com/read/29295990/obligatory-and-facilitative-allelic-variation-in-the-dna-methylome-within-common-disease-associated-loci
#1
Christopher G Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G Hysi, Jun Wang, Timothy D Spector
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify DNA methylation variability between GWAS-SNP risk and non-risk haplotypes. In three subsets comprising 3128 MeDIP-seq peripheral-blood DNA methylomes, we find 7173 consistent and functionally enriched Differentially Methylated Regions...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29273918/a-review-of-atypical-subtrochanteric-femoral-fractures-in-northern-ireland-between-2010-and-2014
#2
K J Donnelly, A Tucker, B Kerr, S McDonald, D S O'Longain, J D Acton
The term atypical femoral fractures most commonly occur in the subtrochanteric area. Concerns exist regarding the role of bisphosphonate treatment in their aetiology. Which surgical intervention provides the best outcome remains contentious. We reviewed all atypical subtrochanteric femoral fractures treated in Northern Ireland over 5 years, specifically investigating incidence, prodromal symptoms, association with bisphosphonates and optimal fixation methods. All subtrochanteric fractures treated in the region were identified and reviewed for atypical features...
December 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29230481/biological-responses-in-brook-trout-salvelinus-fontinalis-caged-downstream-from-municipal-wastewater-treatment-plants-in-the-credit-river-on-canada
#3
Stephen McGovarin, Tamanna Sultana, Chris Metcalfe
To determine whether discharges of contaminants from municipal wastewater treatment plants (WWTPs) may be contributing to the decline in populations of brook trout (Salvelinus fontinalis) in the watershed of the Credit River in ON, Canada, we caged juvenile brook trout upstream and downstream of the WWTPs of the small communities of Acton and Orangeville. Levels of vitellogenin were significantly elevated in liver tissue of trout caged downstream of both WWTPs, indicating exposure to estrogenic substances. Levels of thiobarbituric acid reactive substances indicative of oxidation of lipids were elevated in the gill tissue of brook trout caged downstream of the Orangeville WWTP, and levels of total glutathione were significantly lower in the gills of brook trout caged downstream of the Acton WWTP...
December 11, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29183751/the-impact-of-work-related-burn-injury-on-social-reintegration-outcomes-a-life-impact-burn-recovery-evaluation-libre-study
#4
Jeffrey C Schneider, Vivian L Shie, Leda Espinoza, Gabriel D Shapiro, Austin Lee, Amy Acton, Molly Marino, Alan Jette, Lewis E Kazis, Colleen M Ryan
OBJECTIVE: To examine differences in long-term social reintegration outcomes for burn survivors with and without work-related injuries. DESIGN: Cross-sectional survey. SETTING: Community-dwelling burn survivors. PARTICIPANTS: Burn survivors (N = 601) aged ≥18 years with injuries ≥5% total body surface area or burns to critical areas (hands, feet, face, or genitals). INTERVENTIONS: Not applicable...
November 25, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29174772/leaders-by-example-best-practices-and-advice-on-establishing-a-state-of-the-art-surgical-simulation-center-that-optimizes-available-resources
#5
A K Gardner, E M Ritter, B J Dunkin, D S Smink, J N Lau, J T Paige, R Phitayakorn, R D Acton, D Stefanidis, D W Gee
BACKGROUND: The role of simulation-based education continues to expand exponentially. To excel in this environment as a surgical simulation leader requires unique knowledge, skills, and abilities that are different from those used in traditional clinically-based education. METHODS: Leaders in surgical simulation were invited to participate as discussants in a pre-conference course offered by the Association for Surgical Education. Highlights from their discussions were recorded...
November 7, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29146460/the-impact-of-price-and-nutrition-labelling-on-sugary-drink-purchases-results-from-an-experimental-marketplace-study
#6
Rachel B Acton, David Hammond
OBJECTIVE: To examine the effect of front-of-package (FOP) nutrition labelling and sugary drink taxation on consumer beverage purchases. METHODS: A total of 675 respondents aged 16 years and older participated in an experimental marketplace study using a 4 × 5 within-between group design. Participants were randomised to one of four labelling conditions (no label; star rating; high sugar symbol; health warning) and completed five within-subject purchase tasks...
November 13, 2017: Appetite
https://www.readbyqxmd.com/read/29136614/impact-of-early-infant-growth-duration-of-breastfeeding-and-maternal-factors-on-total-body-fat-mass-and-visceral-fat-at-3-and-6-months-of-age
#7
Laura M Breij, Marieke Abrahamse-Berkeveld, Dennis Acton, Emanuella De Lucia Rolfe, Ken K Ong, Anita C S Hokken-Koelega
BACKGROUND: Accelerated gain in fat mass in the first months of life is considered to be a risk factor for adult diseases, given the tracking of infancy fat mass into adulthood. Our objective was to assess the influence of early growth, type of feeding and maternal variables on fat mass in early life. METHODS: In 300 healthy term infants, we longitudinally measured fat mass percentage (FM%) by air-displacement-plethysmography at 1, 3, and 6 months and abdominal visceral and subcutaneous fat measured by ultrasound at 3 and 6 months...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29097179/long-term-social-reintegration-outcomes-for-burn-survivors-with-and-without-peer-support-attendance-a-life-impact-burn-recovery-evaluation-libre-study
#8
Brian Grieve, Gabriel D Shapiro, Lucy Wibbenmeyer, Amy Acton, Austin Lee, Molly Marino, Alan Jette, Jeffrey C Schneider, Lewis E Kazis, Colleen M Ryan
OBJECTIVE: To examine differences in long-term social reintegration outcomes for burn survivors with and without peer support attendence. DESIGN: Cross-sectional survey. SETTING: Community-dwelling burn survivors. PARTICIPANTS: Burn survivors (N = 601) aged ≥18 years with injuries to ≥5% total body surface area or burns to critical areas (hands, feet, face, or genitals). INTERVENTIONS: Not applicable...
October 30, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29053460/sdl-saliency-based-dictionary-learning-framework-for-image-similarity
#9
Rituparna Sarkar, Scott T Acton
In image classification, obtaining adequate data to learn a robust classifier has often proven to be difficult in several scenarios. Classification of histological tissue images for health care analysis is a notable application in this context due to the necessity of surgery, biopsy or autopsy. To adequately exploit limited training data in classification, we propose a saliency guided dictionary learning method and subsequently an image similarity technique for histo-pathological image classification. Salient object detection from images aids in the identification of discriminative image features...
October 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28961064/spinal-circuits-for-touch-pain-and-itch
#10
Stephanie C Koch, David Acton, Martyn Goulding
The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somatosensory modalities of touch, itch, and pain. Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuron cell types...
September 27, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/28954893/gliotransmission-and-adenosinergic-modulation-insights-from-mammalian-spinal-motor-networks
#11
David Acton, Gareth Brian Miles
Astrocytes are proposed to converse with neurons at tripartite synapses, detecting neurotransmitter release and responding with release of gliotransmitters, which in turn modulate synaptic strength and neuronal excitability. However, a paucity of evidence from behavioral studies calls into question the importance of gliotransmission for the operation of the nervous system in healthy animals. Central pattern generator (CPG) networks in the spinal cord and brainstem coordinate the activation of muscles during stereotyped activities such as locomotion, inspiration and mastication, and may therefore provide tractable models in which to assess the contribution of gliotransmission to behaviorally relevant neural activity...
September 27, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28918946/cooperative-behavior-emerges-among-drosophila-larvae
#12
Mark Dombrovski, Leanne Poussard, Kamilia Moalem, Lucia Kmecova, Nic Hogan, Elisabeth Schott, Andrea Vaccari, Scott Acton, Barry Condron
Spectacular examples of cooperative behavior emerge among a variety of animals and may serve critical roles in fitness [1, 2]. However, the rules governing such behavior have been difficult to elucidate [2]. Drosophila larvae are known to socially aggregate [3, 4] and use vision, mechanosensation, and gustation to recognize each other [5-8]. We describe here a model experimental system of cooperative behavior involving Drosophila larvae. While foraging in liquid food, larvae are observed to align themselves and coordinate their movements in order to drag a common air cavity and dig deeper...
September 25, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28900304/the-campaign-for-a-national-strategy-for-gypsy-site-provision-and-the-role-of-public-health-activism-in-the-1960-1970s
#13
David Smith, Thomas Acton
We trace the post-war evolution of a national approach to providing caravan sites for Gypsies and Travellers-something essential to protect the health of that population in the United Kingdom (UK). Throughout the 1950s and 1960s, the late Norman Dodds MP championed in Parliament the plight of the UK's Gypsies and other nomads. He was instrumental in galvanising support for the 1968 Caravan Sites Act. The vision of influential individuals working in public and environmental health surmounted practical considerations and local opposition to implement the national programme of site provision envisioned by the Act...
September 12, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28888383/developing-item-response-theory-based-short-forms-to-measure-the-social-impact-of-burn-injuries
#14
Molly Marino, Emily C Dore, Pengsheng Ni, Colleen M Ryan, Jeff C Schneider, Amy Acton, Alan M Jette, Lewis E Kazis
OBJECTIVE: To develop self-reported short forms for the LIBRE Profile. DESIGN: Participants were selected for inclusion in the short forms based upon the item parameters of discrimination and average difficulty. Test information function, as well as floor and ceiling effects, were evaluated for both the full item bank and the short forms. SETTING: Participants were recruited were from the Phoenix Society (a support network for burn survivors), peer support networks, social media, and mailings...
September 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28888313/aftercare-survivorship-and-peer-support
#15
REVIEW
Karen Badger, Amy Acton, Pam Peterson
Burn recovery includes addressing any emotional, psychological, and social needs of the survivor and family. Providing support and resources is essential for a smooth transition from the acute phase of injury to rehabilitation and successful social and community reintegration. Priority psychosocial target areas are developing social skills, addressing body image concerns, and providing peer support. Peer support provides a unique perspective of shared experience that can instill hope and assist coping efforts of survivors and family...
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28860404/the-changing-face-of-fractures-of-the-hip-in-northern-ireland-a-15-year-review
#16
A Tucker, K J Donnelly, S McDonald, J Craig, A P Foster, J D Acton
AIMS: We reviewed all patients who sustained a fracture of the hip and were treated in Northern Ireland over a period of 15 years to identify trends in incidence, the demographics of the patients, the rates of mortality, the configuration of the fracture and the choice of implant. PATIENTS AND METHODS: Since 01 January 2001 data about every fracture of the hip sustained in an adult have been collected centrally in Northern Ireland. All adults with such a fracture between 2000 and 2015 were included in the study...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28840398/delayed-sciatic-nerve-compression-following-hamstring-injury
#17
J Macdonald, S E McMahon, D O'Longain, J D Acton
A 47-year-old man presented three months post-hamstring injury with posterior thigh and buttock pain, paraesthesia over the lateral part of the leg and dorsum of the foot and a foot drop. MRI identified a hamstring muscle injury with a lesion surrounding 20 cm of the proximal sciatic nerve consistent with an extensive haematoma. Surgical debridement and release was planned; however, his signs spontaneously resolved with rest, physiotherapy and splintage prior to surgery. There have been no other reports of a sciatic nerve lesion with neurological signs resolving without surgical exploration...
August 24, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28832462/quality-and-safety-education-for-nurses-competencies-in-doctor-of-nursing-practice-education-exemplars-from-education-and-practice
#18
Cindy Acton, Susan Farus-Brown, Catherine Alexander, Linda Morrow, Julianne Ossege, Elizabeth Tovar
Graduate level Quality and Safety Education for Nurses (QSEN) competencies were created to facilitate preparation of the Doctor of Nursing Practice (DNP) graduate to have an impact on health care system changes, advance nursing practice, and improve the health of populations. Although there is agreement that QSEN competencies are important to DNP education, little is known about implementation of the competencies. This article describes the importance of QSEN competencies in DNP education and provides exemplars of QSEN competencies in DNP education and practice...
September 2017: Nurse Educator
https://www.readbyqxmd.com/read/28753733/lost-in-translation-no-effect-of-a-high-profile-publication-on-the-concomitant-use-of-interacting-drugs
#19
Emily K Acton, Charles E Leonard, Warren B Bilker, Shobha Phansalkar, Sean Hennessy
We sought to assess whether a high-profile publication that demonstrated serious clinical consequences of specific drug-drug interactions (DDIs) reduced the concomitant use of those drugs. We conducted a quasi-experimental study using 2000-2008 prescription claims from a commercial health insurer to examine trends in the dispensing of the interacting drug pairs (angiotensin-converting enzyme inhibitors[ACEI] + potassium-sparing diuretic, digoxin + clarithromycin, and glyburide + cotrimoxazole) and control drug pairs previously reported in a top-tier general medicine journal...
November 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28698185/age-at-menarche-and-late-adolescent-adiposity-associated-with-mammographic-density-on-processed-digital-mammograms-in-24-840-women
#20
Stacey E Alexeeff, Nnaemeka U Odo, Jafi A Lipson, Ninah Achacoso, Joseph H Rothstein, Martin J Yaffe, Rhea Y Liang, Luana Acton, Valerie McGuire, Alice S Whittemore, Daniel L Rubin, Weiva Sieh, Laurel A Habel
Background: High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density.Methods: The study cohort (N = 24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females ages 40 to 74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were measured by a radiological technologist using Cumulus...
September 2017: Cancer Epidemiology, Biomarkers & Prevention
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