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Nassir ghaemi

S Nassir Ghaemi
No abstract text is available yet for this article.
April 18, 2017: British Journal of Clinical Pharmacology
Alexander McGirr, Paul A Vöhringer, S Nassir Ghaemi, Raymond W Lam, Lakshmi N Yatham
BACKGROUND: Although mania and hypomania define bipolar disorder, depressive episodes are more common and impairing, with few proven treatments. Adjunctive therapy with second-generation antidepressants is widely used to treat acute bipolar depression, but their efficacy and safety remain controversial. METHODS: In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and from inception to Jan 31, 2016, for randomised, double-blind, placebo-controlled trials of second-generation antidepressants adjunctive to a mood stabiliser or an antipsychotic in patients with acute bipolar depression...
December 2016: Lancet Psychiatry
John Torous, Paul Summergrad, S Nassir Ghaemi
"Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep."-Dr. Sutherland (Br J Psychiatry 7(37):1-19, 1861). Dr. Sutherland's patient was suffering from an acute manic episode, which today is called bipolar illness. 150 years later, we continue to struggle with the same challenges in ascertaining accurate symptoms from patients. In era of new digital tools, the quantified self-movement, and precision medicine, we can ask the question: Can we advance understanding and treatment for bipolar illness beyond asking the same questions as in 1861?...
December 2016: International Journal of Bipolar Disorders
Andrea Amerio, Brendon Stubbs, Anna Odone, Matteo Tonna, Carlo Marchesi, S Nassir Ghaemi
CONTEXT: More than half of the bipolar disorder (BD) cases have an additional diagnosis; one of the most difficult to manage is obsessive-compulsive disorder (OCD). Although some authors recently investigated the co-occurrence of anxiety and BD, the topic remains insufficiently studied. The current study aimed to investigate differences in comorbid OCD between BD-I and BD-II. EVIDENCE ACQUISITION: A systematic review and meta-analysis was conducted on the prevalence and predictors of comorbid BD-I/BD-II and OCD...
September 2016: Iranian Journal of Psychiatry and Behavioral Sciences
Georgios D Kotzalidis, Chiara Rapinesi, Valeria Savoja, Ilaria Cuomo, Alessio Simonetti, Elisa Ambrosi, Isabella Panaccione, Silvia Gubbini, Pietro De Rossi, Lavinia De Chiara, Delfina Janiri, Gabriele Sani, Alexia E Koukopoulos, Giovanni Manfredi, Flavia Napoletano, Matteo Caloro, Lucia Pancheri, Antonella Puzella, Gemma Callovini, Gloria Angeletti, Antonio Del Casale
BACKGROUND: Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania. OBJECTIVE: To identify evidence in literature that supports or falsifies this hypothesis. METHOD: We searched the medical literature (PubMed, Embase, PsycINFO, and the Cochrane Library) for peer-reviewed papers on the primacy of mania, the default mode function of the brain in normal people and in bipolar disorder patients, and on illusion superiority until 6 June, 2016...
July 8, 2016: Current Neuropharmacology
S Nassir Ghaemi, Paul A Vohringer
BACKGROUND: Athanasios Koukopoulos provided a radical model for understanding depressive and manic conditions. OBJECTIVE: To review, explain, and analyze Koukopoulos' concept of the primacy of mania, with special attention to the role of antidepressants. METHOD: A conceptual review of Koukopoulos' writings and lectures on this topic is given. RESULTS: Koukopoulos held that depressive states are caused by manic states; the former do not occur without the latter...
June 21, 2016: Current Neuropharmacology
Andrea Amerio, Matteo Tonna, Anna Odone, S Nassir Ghaemi
No abstract text is available yet for this article.
May 2016: Psychiatry Investigation
Matteo Tonna, Andrea Amerio, Anna Odone, Brendon Stubbs, S Nassir Ghaemi
A full-text Chinese translation of this article will be available at on April 25, 2016.
December 25, 2015: Shanghai Archives of Psychiatry
Andrea Amerio, Matteo Tonna, Anna Odone, Brendon Stubbs, S Nassir Ghaemi
Partly due to the overlap of symptom groupings in DSM, psychiatric comorbidity is extremely common. One of the most common and difficult to manage comorbid conditions is the co-occurrence of bipolar disorder (BD) and obsessive compulsive disorder (OCD). However, the key nosological question about this condition - whether they are two distinct disorders or a subtype of one of the disorders - remains unresolved. In order to help address this unanswered question, we updated our recent systematic review, searching the electronic databases MEDLINE, Embase, and PsycINFO to specifically investigate the heredity in BD-OCD patients...
October 2015: Shanghai Archives of Psychiatry
S Nassir Ghaemi
No abstract text is available yet for this article.
February 2016: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Matteo Tonna, Andrea Amerio, Anna Odone, Brendon Stubbs, S Nassir Ghaemi
No abstract text is available yet for this article.
July 2016: Australian and New Zealand Journal of Psychiatry
Paul A Vöhringer, Michael J Ostacher, Rif S El-Mallakh, Niki S Holtzman, Sairah B Thommi, Elizabeth A Whitham, Matthew C Sullivan, Claudia F Baldassano, Fredrick K Goodwin, Ross J Baldessarini, S Nassir Ghaemi
BACKGROUND: We sought to test the hypothesis that antidepressants (ADs) may show preferential efficacy and safety among patients with type II bipolar disorder (BD, BD-II) more than patients with type I BD (BD-I). METHODS: Patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, BD-I (n = 21) and BD-II (n = 49) in acute major depressive episodes were treated with ADs plus mood stabilizers to euthymia sustained for 2 months and then randomized openly to continue or discontinue ADs for up to 3 years...
October 2015: Journal of Clinical Psychopharmacology
Rif S El-Mallakh, Paul A Vöhringer, Michael M Ostacher, Claudia F Baldassano, Niki S Holtzman, Elizabeth A Whitham, Sairah B Thommi, Frederick K Goodwin, S Nassir Ghaemi
BACKGROUND: The use of antidepressants in rapid-cycling bipolar disorder has been controversial. We report the first randomized clinical trial with modern antidepressants on this topic. METHODS: As part of the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study, we analyzed, as an a priori secondary outcome, rapid cycling as a predictor of response in 68 patients randomized to continue vs. discontinue antidepressant treatment, after initial response for an acute major depressive episode...
September 15, 2015: Journal of Affective Disorders
S Nassir Ghaemi
INTRODUCTION: Current classifications of psychotropic drugs, developed in the 1960s, are based on beliefs about clinical effectiveness. This article evaluates the scientific validity of current drug terms and possible alternative classifications. METHODS: A historical, conceptual, and empirical review of the psychopharmacology literature is provided. Consistency of classification is examined by 3 major categories: chemical structure, pharmacodynamic mechanism, and clinical efficacy...
August 2015: Journal of Clinical Psychopharmacology
Andrea Amerio, Juan Francisco Gálvez, Anna Odone, Shannon A Dalley, S Nassir Ghaemi
OBJECTIVE: The US Food and Drug Administration approval process for psychotropic drugs requires safety studies of carcinogenicity in animals. These studies are consistently conducted and provide a database for assessment of potential biological risk of carcinogenicity in humans. This report is a systematic review of that database for psychotropic drugs. METHOD: US Food and Drug Administration-approved registration data ('package inserts') were examined, where available, for all psychotropic drugs in the following classes: antidepressants, antipsychotics, benzodiazepines/sedative-hypnotics, amphetamines and anticonvulsants...
August 2015: Australian and New Zealand Journal of Psychiatry
Ashwin A Patkar, Chi-Un Pae, Paul A Vöhringer, Sivan Mauer, Meera Narasimhan, Shannon Dalley, Antony Loebel, Prakash S Masand, S Nassir Ghaemi
OBJECTIVE: Features of bipolarity in a major depressive disorder sample were used to define a "bipolar spectrum disorder" population for treatment with a neuroleptic agent, ziprasidone. METHODS: Forty-nine acutely depressed patients were randomized to ziprasidone-washout-placebo or placebo-washout-ziprasidone in this double-blind, prospective, 13-week crossover trial. All patients met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for a major depressive episode and were positive for at least 3 predictors of bipolarity: family history of bipolar disorder, antidepressant-induced mania, highly recurrent depressive episodes (>5), atypical depression, early onset of depression (<age 20), failure to respond to antidepressants or antidepressant tolerance...
June 2015: Journal of Clinical Psychopharmacology
Gabriele Sani, Flavia Napoletano, Paul A Vöhringer, Matthew Sullivan, Alessio Simonetti, Athanasios Koukopoulos, Emanuela Danese, Paolo Girardi, Nassir Ghaemi
BACKGROUND: Mixed depression (MxD) is narrowly defined in the DSM-IV and somewhat broader in the DSM-5, although both exclude psychomotor agitation as a diagnostic criterion. This article proposes a clinical description for defining MxD, which emphasizes psychomotor excitation. METHODS: Two hundred and nineteen consecutive outpatients were diagnosed with an MxD episode using criteria proposed by Koukopoulos et al. [Acta Psychiatr Scand 2007;115(suppl 433):50-57]; we here report their clinical features and antidepressant-related effects...
2014: Psychotherapy and Psychosomatics
Sivan Mauer, Rami Alahmari, Paul A Vöhringer, Derick E Vergne, H Lövdahl, E Correa, A Patkar, C Pae, S Strejilevich, S Dalley, S Nassir Ghaemi
OBJECTIVE: To show the feasibility of creating an international network that will build a common database for mood disorders research, and to present initial data on prescribing patterns worldwide. METHODS: An international research database was organized with clinicians and researchers actively treating mood disorders. Participating sites were asked to provide data on 10-50 subjects initially. This work was conducted under the auspices of a committee with representatives from North and South America, Europe, and Asia...
2014: Journal of Affective Disorders
Sivan Mauer, Derick Vergne, S Nassir Ghaemi
OBJECTIVE: Dementia is a major public health issue, with notably high rates in persons with mood illnesses. Lithium has been shown to have considerable neuroprotective effects, even in trace or low doses. The aim of this review is to summarize the current understanding of lithium benefits in trace or low doses in dementia prevention and for other behavioral or medical benefits. METHODS: A systematic review identified 24 clinical, epidemiological, and biological reports that met inclusion criteria of assessing lithium in standard or low doses for dementia or other behavioral or medical benefits...
September 2014: Australian and New Zealand Journal of Psychiatry
Gabriele Sani, Paul A Vöhringer, Flavia Napoletano, Niki S Holtzman, Shannon Dalley, Paolo Girardi, S Nassir Ghaemi, Athanasios Koukopoulos
BACKGROUND: Mixed depression (MxD) is one subtype of depressive experiences within the depressive spectrum. MxD definition is debated among experts. Koukopoulos׳ proposed diagnostic criteria focused primarily on psychic agitation, marked irritability, and intense mood lability as markers of a mixed depressive episode. The present study validates Koukopoulos׳ criteria as diagnostic for MxD. METHODS: A sample of 435 patients from the International Mood Network (IMN), multi-center, international network of sites, and the Centro LucioBini of Rome was analyzed...
August 2014: Journal of Affective Disorders
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