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https://www.readbyqxmd.com/read/29656607/expert-agreement-in-the-interpretation-of-lung-ultrasound-studies-performed-on-mechanically-ventilated-patients
#1
Scott J Millington, Robert T Arntfield, Robert Jie Guo, Seth Koenig, Pierre Kory, Vicki Noble, Haney Mallemat, Jordan R Schoenherr
OBJECTIVES: Although lung ultrasound (US) has been shown to have high diagnostic accuracy in patients presenting with acute dyspnea, its precision in critically ill patients is unknown. We investigated common areas of agreement and disagreement by studying 6 experts as they interpreted lung US studies in a cohort of intensive care unit (ICU) patients. METHODS: A previous study by our group asked experts to rate the quality of 150 lung US studies performed by 10 novices in a population of mechanically ventilated patients...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29656531/post-traumatic-stress-disorder-and-risk-of-osteoporosis-a-nationwide-longitudinal-study
#2
Wei-Sheng Huang, Ju-Wei Hsu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Tzeng-Ji Chen, Shih-Jen Tsai, Ying-Jay Liou, Mu-Hong Chen
Several studies suggested a relationship between stress and related mental illnesses, such as depression and osteoporosis. However, it was unclear whether patients with post-traumatic stress disorder (PTSD) were at risk of developing osteoporosis in later life. In this study, 6,041 patients with PTSD and 24,164 age- or sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Cases of osteoporosis were identified during the follow-up. Patients with PTSD had an elevated likelihood of developing osteoporosis (HR: 2...
April 15, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29655596/validation-of-the-nursing-workload-scoring-systems-nursing-activities-score-nas-and-therapeutic-intervention-scoring-system-for-critically-ill-children-tiss-c-in-a-greek-paediatric-intensive-care-unit
#3
Alexandra-Stavroula Nieri, Kalliopi Manousaki, Maria Kalafati, Katia Grilio Padilha, Siv K Stafseth, Theodoros Katsoulas, Vasiliki Matziou, Margarita Giannakopoulou
OBJECTIVES: To assess the reliability and validity of the Greek version of Nursing Activities Score (NAS), and Therapeutic Intervention Scoring System for Critically Ill Children (TISS-C) in a Greek Paediatric Intensive Care Unit (PICU). RESEARCH METHODOLOGY: A methodological study was performed in one PICU of the largest Paediatric Hospital in Athens-Greece. The culturally adapted and validated Greek NAS version, enriched according to the Norwegian paediatric one (P-NAS), was used...
April 11, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29655528/a-mobile-app-for-patients-with-pompe-disease-and-its-possible-clinical-applications
#4
Giulia Ricci, Sigrid Baldanzi, Fabrizio Seidita, Chiara Proietti, Francesca Carlini, Silvia Peviani, Giovanni Antonini, Andrea Vianello, Gabriele Siciliano
In recent years, the potential of smart technology to provide innovative solutions for disease management has raised high expectations for patients' and healthcare professionals' community. We developed a mobile app, called AIGkit, specifically designed for adult patients with Pompe disease, with the aim to help them manage the burden of illness-related factors, and also to provide clinicians with continuous tracking of each patient in real-time and ambient conditions of everyday life. We present the AIGkit as an innovative approach exploiting cutting-edge technology to improve quality of care and research into neuromuscular disorders...
March 12, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29655448/generalized-myasthenia-gravis-classification-clinical-presentation-natural-history-and-epidemiology
#5
REVIEW
Michael K Hehir, Nicholas J Silvestri
Myasthenia gravis (MG) is a rare disease, but the most common disorder of the neuromuscular junction. It is the prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine receptor (AChR) leading to characteristic fatigable weakness of the ocular, bulbar, respiratory, axial, and limb muscles. The majority of patients with MG first present with ocular symptoms. Most patients with MG will experience at least 1 exacerbation of symptoms throughout the course of their illness. This article will cover the epidemiology, clinical presentation, classification, and natural history of MG...
May 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29655372/population-pharmacokinetics-pharmacodynamics-of-micafungin-against-candida-species-in-obese-critically-ill-and-morbidly-obese-critically-ill-patients
#6
Emilio Maseda, Santiago Grau, Sonia Luque, Maria-Pilar Castillo-Mafla, Alejandro Suárez-de-la-Rica, Ana Montero-Feijoo, Patricia Salgado, Maria-Jose Gimenez, Carlos A García-Bernedo, Fernando Gilsanz, Jason A Roberts
BACKGROUND: Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and it remains fully unexplored. This study estimated the micafungin probability of reaching adequate 24-h area under the curve (AUC0-24h )/minimum inhibitory concentration (MIC) values against Candida spp. for an obese/nonobese, critically ill/noncritically ill, large population. METHODS: Blood samples for pharmacokinetic analyses were collected from 10 critically ill nonobese patients, 10 noncritically ill obese patients, and 11 critically ill morbidly obese patients under empirical/directed micafungin treatment...
April 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29653344/a-randomized-controlled-trial-of-comprehensive-early-intervention-care-in-patients-with-first-episode-psychosis-in-japan-1-5-year-outcomes-from-the-j-cap-study
#7
Atsushi Nishida, Shuntaro Ando, Syudo Yamasaki, Shinsuke Koike, Kayo Ichihashi, Yuji Miyakoshi, Sanae Maekawa, Tomohisa Nakamura, Tatsunobu Natsubori, Eriko Ichikawa, Hiroki Ishigami, Kojiro Sato, Asami Matsunaga, Jo Smith, Paul French, Hirohiko Harima, Yoshiki Kishi, Izumi Fujita, Kiyoto Kasai, Yuji Okazaki
The first episode of psychosis represents a critical period wherein comprehensive early intervention in psychosis (EIP) may alter the course of illness. However, evidence from randomized controlled trials that have examined the impact of comprehensive EIP care on clinical and functional recovery assessed by independent blinded raters is limited. The objective of this study was to conduct a single-blinded multicenter trial comparing comprehensive EIP care and standard care in young patients with first-episode psychosis (FEP) in Japan (J-CAP Study)...
April 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29653245/improved-clinical-documentation-leads-to-superior-reportale-outcomes-an-accurate-representation-of-patient-s-clinical-status
#8
Adel Elkbuli, Steven Godelman, Ashley Miller, Dessy Boneva, Eileen Bernal, Shaikh Hai, Mark McKenney
INTRODUCTION: Clinical documentation can be an underappreciated. Trauma Centers (TCs) are now routinely evaluated for quality performance. TCs with poor documentation may not accurately reflect actual injury burden or comorbidities and can impact accuracy of mortality measures. Markers exist to adjust crude death rates for injury severity: observed over expected deaths (O/E) adjust for injury; Case Mix Index (CMI) reflects disease burden, and Severity of Illness (SOI) measures organ dysfunction...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29652945/clinical-evaluation-and-validation-of-laboratory-methods-for-the-diagnosis-of-bordetella-pertussis-infection-culture-polymerase-chain-reaction-pcr-and-anti-pertussis-toxin-igg-serology-igg-pt
#9
Adria D Lee, Pamela K Cassiday, Lucia C Pawloski, Kathleen M Tatti, Monte D Martin, Elizabeth C Briere, M Lucia Tondella, Stacey W Martin
INTRODUCTION: The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of different diagnostic criteria including culture, multi-target polymerase chain reaction (PCR), anti-pertussis toxin IgG (IgG-PT) serology, and the use of a clinical case definition. An additional objective was to describe the optimal timing of specimen collection for the various tests...
2018: PloS One
https://www.readbyqxmd.com/read/29652870/surveillance-for-the-identification-of-cases-of-acute-respiratory-infection-by-enterovirus-d68-in-children-in-a-tertiary-level-care-hospital-during-2014-2016
#10
Ana Estela Gamiño-Arroyo, José Luis Sánchez-Huerta, Alicia Elhaín de la Garza-López, Israel Parra-Ortega, Noé Escobar-Escamilla, Edgar Mendieta-Condado, Fabiola Garcés-Ayala, Gisela Barrera-Badillo, José Ernesto Ramírez-González, José Alberto Díaz-Quiñonez, Daniela de la Rosa-Zamboni
Background: The reemergence of enterovirus D68 (EV-D68) infections in the United States was reported from August-October 2014 (691 cases). In Mexico, an outbreak at the National Institute of Respiratory Diseases was reported (24 cases). The results of epidemiological surveillance of Enterovirus sp. (EV) and other respiratory viruses in a national pediatric tertiary care level hospital are presented. Methods: Following the alert issued by the reemergence of EV-D68 in 2014, epidemiological surveillance -which only detected respiratory viruses by PCR in patients with influenza-like illness using nasopharyngeal swabs- expanded to include children with asthma exacerbation or acute respiratory distress...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29652769/schizophrenia-and-criminal-responsibility-a-systematic-review
#11
Georgios Tsimploulis, Gérard Niveau, Ariel Eytan, Panteleimon Giannakopoulos, Othman Sentissi
The significant progress of psychiatry in the 20th century provided a sophisticated theoretical framework to analyze the complex relationships between crime and mental illness. Schizophrenia has been traditionally associated with severe cognitive and affective deficits that heavily influence empathy, judgment capacities, but also control of impulsiveness. Although there is an association between psychotic disorders and absence or decrease of legal responsibility, their relationship is also determined by sociodemographic, developmental, and clinical factors...
May 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29652705/is-procalcitonin-guided-therapy-associated-with-beneficial-outcomes-in-critically-ill-patients-with-sepsis
#12
Andre C Kalil, Trevor C Van Schooneveld
No abstract text is available yet for this article.
May 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29652593/vitamin-d-status-in-hospitalized-chronically-ill-patients
#13
Raef Malak Botros, Mona Mohamed AbdElsalam Besibes, Ahmed Mohamed Bahaaeldin, Sherihan Abo Elyazed
OBJECTIVES: Vitamin D deficiency is rarely considered or treated in critically ill patients. Deficiency of 25-hydroxy vitamin D [25(OH)D] prior to hospital admission might be a significant predictor of short- and long-term all cause patient mortality in a critically ill patient. The aim of this work is to investigate the prevalence of vitamin D deficiency in hospitalized patients and its relation to the length of stay and outcome of hospitalization. METHODS: Prospective cohort study performed on 80 patients admitted with acute deterioration of their chronic illness...
April 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29652241/bacterial-burden-in-critically-injured-ventilated-patients-does-not-correlate-with-progression-to-pneumonia
#14
Bradley M Dennis, Richard D Betzold, Daryl Patton, Herbert A Hopper, Judith Jenkins, Chris Fonnesbeck, Wonder Drake, Addison K May
BACKGROUND: Ventilator-associated pneumonia (VAP) is common in critically injured patients. The pathogenesis of VAP is not completely understood. We hypothesized that mechanically ventilated trauma patients who develop pneumonia have a progressive increase in pathogen burden over the course of ventilation until a threshold for symptomatic pneumonia is reached, leading to clinical suspicion of VAP. METHODS: Critically injured adults ventilated for more than two successive days were enrolled...
March 13, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29652103/a-10-year-follow-up-study-of-japanese-patients-with-obsessive-compulsive-disorder
#15
Akihiro Nakajima, Naomi Matsuura, Keiichiro Mukai, Kyosuke Yamanishi, Hisashi Yamada, Kensei Maebayashi, Kazuhisa Hayashida, Hisato Matsunaga
AIM: Obsessive-compulsive disorder is a well-known chronic illness. This study retrospectively investigated 10-year outcomes and associated clinical factors in Japanese obsessive-compulsive disorder patients. We focused on the impact of several sociocultural factors, including medical expenses and insurance systems specific to each country, on the differences or biases in follow-up procedures of obsessive-compulsive disorder. METHODS: Seventy-nine patients diagnosed with obsessive-compulsive disorder who received a standardized combination of treatments for 10 continuous years were divided into three groups according to their improvement rates on the Yale-Brown Obsessive-Compulsive Scale after 10 years of treatment...
April 13, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29651400/management-of-a-case-of-mucor-colonization-in-breast-tissue-expander-seroma-pocket
#16
Danielle N Atwood, Pallavi A Kumbla, Brian Yuen, James C Yuen
Mucormycosis has a mortality rate reaching 90%, and is imperative that therapy be initiated rapidly once a diagnosis is made. Successful treatment consists of management of underlying risk factors, surgical debridement, and antifungal therapies. The dilemma whether or not to pursue extensive debridement presents when the wound is cultured positive but the patient is not systemically ill. We present the first reported case of successful medical treatment of a seroma pocket colonized with mucor in a patient undergoing bilateral reconstruction with tissue expander and acellular dermal matrix...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651352/prolonged-survival-of-acute-lymphoblastic-leukemia-with-intrathecal-treatments-for-isolated-central-nervous-system-relapse
#17
Elan Gorshein, Sheila Kalathil, Mecide Gharibo
Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present in adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among the elderly and high-risk populations. In the absence of prophylactic intrathecal chemotherapy, more than half of patients may develop CNS involvement or relapse, which is associated with significant risk for systemic illness. This report describes a patient with acute lymphoblastic leukemia with repeated isolated CNS relapses...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29651334/the-evaluation-of-risk-prediction-models-in-predicting-outcomes-after-bariatric-surgery-a-prospective-observational-cohort-pilot-study
#18
David Andrew Gilhooly, Michelle Cole, Suneetha Ramani Moonesinghe
Background: As the prevalence of obesity is increasing, the number of patients requiring surgical intervention for obesity-related illness is also rising. The aim of this pilot study was to explore predictors of short-term morbidity and longer-term poor weight loss after bariatric surgery. Methods: This was a single-centre prospective observational cohort pilot study in patients undergoing bariatric surgery. We assessed the accuracy (discrimination and calibration) of two previously validated risk prediction models (the Physiological and Operative Severity Score for the enumeration of Morbidity and Mortality, POSSUM score, and the Obesity Surgical Mortality Risk Score, OS-MS) for postoperative outcome (postoperative morbidity defined using the Post Operative Morbidity Survey)...
2018: Perioperative Medicine
https://www.readbyqxmd.com/read/29651117/field-validation-of-recombinant-antigen-immunoassays-for-diagnosis-of-lassa-fever
#19
Matthew L Boisen, Jessica N Hartnett, Jeffrey G Shaffer, Augustine Goba, Mambu Momoh, John Demby Sandi, Mohamed Fullah, Diana K S Nelson, Duane J Bush, Megan M Rowland, Megan L Heinrich, Anatoliy P Koval, Robert W Cross, Kayla G Barnes, Anna E Lachenauer, Aaron E Lin, Mahan Nekoui, Dylan Kotliar, Sarah M Winnicki, Katherine J Siddle, Michael Gbakie, Mbalu Fonnie, Veronica J Koroma, Lansana Kanneh, Peter C Kulakosky, Kathryn M Hastie, Russell B Wilson, Kristian G Andersen, Onikepe O Folarin, Christian T Happi, Pardis C Sabeti, Thomas W Geisbert, Erica Ollmann Saphire, S Humarr Khan, Donald S Grant, John S Schieffelin, Luis M Branco, Robert F Garry
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a patient's clinical presentation. The field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain assays (qPCRs) using samples from subjects meeting the case definition of Lassa fever presenting to Kenema Government Hospital in Sierra Leone. The recombinant Lassa virus (ReLASV) enzyme-linked immunosorbant assay (ELISA) for detection of viral antigen in blood performed with 95% sensitivity and 97% specificity using a diagnostic standard that combined results of the immunoassays and qPCR...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650883/-cancer-disease-trajectory-and-the-contribution-of-artistic-outreach-activity-to-palliative-care
#20
Hisako Oshiro, Tatsuo Oshiro, Masahito Tanimizu
The purpose of this article is to show some unintentional aspects of palliative supports offered by the community. The activities of the Opera Ehime, an amateur opera group, play an important role in palliative and grief care. This community is also committed to providing supportive care for home hospice cancer patients through an outreach music program that offers patients connection with others and reduces isolation. Assessment by the coordinator includes determiningthe patients' preferences and the relevance of music throughout their lives...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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