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Integrated information theory

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https://www.readbyqxmd.com/read/28209558/readiness-for-delivering-digital-health-at-scale-lessons-from-a-longitudinal-qualitative-evaluation-of-a-national-digital-health-innovation-program-in-the-united-kingdom
#1
Marilyn R Lennon, Matt-Mouley Bouamrane, Alison M Devlin, Siobhan O'Connor, Catherine O'Donnell, Ula Chetty, Ruth Agbakoba, Annemieke Bikker, Eleanor Grieve, Tracy Finch, Nicholas Watson, Sally Wyke, Frances S Mair
BACKGROUND: Digital health has the potential to support care delivery for chronic illness. Despite positive evidence from localized implementations, new technologies have proven slow to become accepted, integrated, and routinized at scale. OBJECTIVE: The aim of our study was to examine barriers and facilitators to implementation of digital health at scale through the evaluation of a £37m national digital health program: ‟Delivering Assisted Living Lifestyles at Scale" (dallas) from 2012-2015...
February 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28204845/mirnas-target-databases-developmental-methods-and-target-identification-techniques-with-functional-annotations
#2
REVIEW
Nagendra Kumar Singh
PURPOSE: microRNA (miRNA) regulates diverse biological mechanisms and metabolisms in plants and animals. Thus, the discoveries of miRNA has revolutionized the life sciences and medical research.The miRNA represses and cleaves the targeted mRNA by binding perfect or near perfect or imperfect complementary base pairs by RNA-induced silencing complex (RISC) formation during biogenesis process. One miRNA interacts with one or more mRNA genes and vice versa, hence takes part in causing various diseases...
February 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28195316/structural-hierarchy-of-autism-spectrum-disorder-symptoms-an-integrative-framework
#3
Hyunsik Kim, Cara M Keifer, Craig Rodriguez-Seijas, Nicholas R Eaton, Matthew D Lerner, Kenneth D Gadow
BACKGROUND: In an attempt to resolve questions regarding the symptom classification of autism spectrum disorder (ASD), previous research generally aimed to demonstrate superiority of one model over another. Rather than adjudicating which model may be optimal, we propose an alternative approach that integrates competing models using Goldberg's bass-ackwards method, providing a comprehensive understanding of the underlying symptom structure of ASD. METHODS: The study sample comprised 3,825 individuals, consecutive referrals to a university hospital developmental disabilities specialty clinic or a child psychiatry outpatient clinic...
February 14, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28193465/application-of-human-augmentics-a-persuasive-asthma-inhaler
#4
Brent Grossman, Steve Conner, Giselle Mosnaim, Joshua Albers, Jason Leigh, Steve Jones, Robert Kenyon
This article describes a tailored health intervention delivered on a mobile phone platform, integrating low-literacy design strategies and basic principles of behavior change, to promote increased adherence and asthma control among underserved minority adolescents. We based the intervention and design principles on theories of Human Augmentics and the Elaboration Likelihood Model. We tested the efficacy of using electronic monitoring devices that incorporate informative and persuasive elements to improve adherence to a prescribed daily medication regimen intended to reduce use of asthma rescue medications...
February 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28188190/identifying-educational-needs-of-the-multidisciplinary-cancer-team-in-the-treatment-of-metastatic-breast-cancer
#5
Priya Wanchoo, Chris Larrison, Carol Rosenberg, Naomi Ko, Cynthia Cantril, Naomi Moeller, Ruchit Parikh, Ana-Marija Djordjevic
Background: Rapid advancements in the field of metastatic breast cancer (mBC) add to the complexity of managing patients with this disease. An educational needs assessment of multidisciplinary mBC clinicians was executed to identify practice performance gaps and recommend educational strategies aimed at closing these gaps. Methods: To ensure a collection of reliable data for assessment, a systematic process was used to design, develop, and validate the tools that were used. This grounded theory approach included assessment and confirmation by clinical experts and validation testing within the target audiences...
February 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28186915/a-novel-variable-precision-reduction-approach-to-comprehensive-knowledge-systems
#6
Chao Yang, Hongbo Liu, Sean McLoone, C L Philip Chen, Xindong Wu
A comprehensive knowledge system reveals the intangible insights hidden in an information system by integrating information from multiple data sources in a synthetical manner. In this paper, we present a variable precision reduction theory, underpinned by two new concepts: 1) distribution tables and 2) genealogical binary trees. Sufficient and necessary conditions to extract comprehensive knowledge from a given information system are also presented and proven. A complete variable precision reduction algorithm is proposed, in which we introduce four important strategies, namely, distribution table abstracting, attribute rank dynamic updating, hierarchical binary classifying, and genealogical tree pruning...
February 8, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28186751/the-relationship-between-solvation-thermodynamics-from-ist-and-dft-perspectives
#7
Ronald M Levy, Di Cui, Bin W Zhang, Nobuyuki Matubayasi
Inhomogeneous Solvation Theory (IST) and classical Density Functional Theory (DFT) each provide a framework for relating distribution functions of solutions to their thermodynamic properties. As reviewed in this work, both IST and DFT can be formulated in a way that use two "end point" simulations, one of the pure solvent and the other of the solution, to determine the solute chemical potential and other thermodynamic properties of the solution and of subvolumes in regions local to the solute containing hydrating waters...
February 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28186392/understanding-the-mtor-signaling-pathway-via-mathematical-modeling
#8
REVIEW
Nurgazy Sulaimanov, Martin Klose, Hauke Busch, Melanie Boerries
The mechanistic target of rapamycin (mTOR) is a central regulatory pathway that integrates a variety of environmental cues to control cellular growth and homeostasis by intricate molecular feedbacks. In spite of extensive knowledge about its components, the molecular understanding of how these function together in space and time remains poor and there is a need for Systems Biology approaches to perform systematic analyses. In this work, we review the recent progress how the combined efforts of mathematical models and quantitative experiments shed new light on our understanding of the mTOR signaling pathway...
February 10, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28186069/the-impact-of-computerized-provider-order-entry-on-nursing-practice
#9
Rosabella Vito, Elizabeth M Borycki, Andre W Kushniruk, Tracey Schneider
Health information systems, such as Computerized Provider Order Entry (CPOE), are suggested to be used as an intervention for addressing errors that arise in the medication process. Nurses are involved in all stages of the medication process; however, little is known about the impact of using CPOE on nursing practice. A grounded theory approach was employed to answer the question of "How do nurses perceive the impact of CPOE on the medication process and collaborative practice?" Ten participants were interviewed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28176413/anomalous-single-subject-based-morphological-cortical-networks-in-drug-naive-first-episode-major-depressive-disorder
#10
Taolin Chen, Keith M Kendrick, Jinhui Wang, Min Wu, Kaiming Li, Xiaoqi Huang, Yuejia Luo, Su Lui, John A Sweeney, Qiyong Gong
Major depressive disorder (MDD) has been associated with disruptions in the topological organization of brain morphological networks in group-level data. Such disruptions have not yet been identified in single-patients, which is needed to show relations with symptom severity and to evaluate their potential as biomarkers for illness. To address this issue, we conducted a cross-sectional structural brain network study of 33 treatment-naive, first-episode MDD patients and 33 age-, gender-, and education-matched healthy controls (HCs)...
February 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28174523/a-principle-for-describing-and-verifying-brain-mechanisms-using-ongoing-activity
#11
David Eriksson
Not even the most informed scientist can setup a theory that takes all brain signals into account. A neuron not only receives neuronal short range and long range input from all over the brain but a neuron also receives input from the extracellular space, astrocytes and vasculature. Given this complexity, how does one describe and verify a typical brain mechanism in vivo? Common to most described mechanisms is that one focuses on how one specific input signal gives rise to the activity in a population of neurons...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28174225/supporting-shared-decision-making-for-older-people-with-multiple-health-and-social-care-needs-a-protocol-for-a-realist-synthesis-to-inform-integrated-care-models
#12
Frances Bunn, Claire Goodman, Jill Manthorpe, Marie-Anne Durand, Isabel Hodkinson, Greta Rait, Paul Millac, Sue L Davies, Bridget Russell, Patricia Wilson
INTRODUCTION: Including the patient or user perspective is a central organising principle of integrated care. Moreover, there is increasing recognition of the importance of strengthening relationships among patients, carers and practitioners, particularly for individuals receiving substantial health and care support, such as those with long-term or multiple conditions. The overall aims of this synthesis are to provide a context-relevant understanding of how models to facilitate shared decision-making (SDM) might work for older people with multiple health and care needs, and how they might be applied to integrated care models...
February 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28168598/brain-activity-underlying-negative-self-and-other-perception-in-adolescents-the-role-of-attachment-derived-self-representations
#13
Martin Debbané, Deborah Badoud, David Sander, Stephan Eliez, Patrick Luyten, Pascal Vrtička
One of teenagers' key developmental tasks is to engage in new and meaningful relationships with peers and adults outside the family context. Attachment-derived expectations about the self and others in terms of internal attachment working models have the potential to shape such social reorientation processes critically and thereby influence adolescents' social-emotional development and social integration. Because the neural underpinnings of this developmental task remain largely unknown, we sought to investigate them by functional magnetic resonance imaging...
February 6, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28165178/experience-of-providing-cultural-safety-in-mental-health-to-aboriginal-patients-a-grounded-theory-study
#14
Shirley McGough, Dianne Wynaden, Michael Wright
The need for mental health clinicians to practice cultural safety is vital in ensuring meaningful care and in moving towards improving the mental health outcomes for Aboriginal people. The concept of cultural safety is particularly relevant to mental health professionals as it seeks to promote cultural integrity and the promotion of social justice, equity and respect. A substantive theory that explained the experience of providing cultural safety in mental health care to Aboriginal patients was developed using grounded theory methodology...
February 6, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28140691/developing-junior-doctors-prescribing-practices-through-collaborative-practice-sustaining-and-transforming-the-practice-of-communities
#15
Christy Noble, Victoria Brazil, Trudy Teasdale, Mark Forbes, Stephen Billett
Prescribing in acute healthcare settings is a complex interprofessional process with a high incidence of medication errors. Opportunities exist to improve prescribing learning through collaborative practice. This qualitative interview-based study aimed to investigate the development of junior doctors' prescribing capacity and how pharmacists contribute interprofessionally to this development and the prescribing practices of a medical community. The setting for this study was a large teaching hospital in Australia where ethical approval was gained before commencing the study...
January 31, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28139902/the-undergraduate-teaching-of-vascular-surgery-in-greek-medical-schools-theory-and-clinical-practice
#16
Vasileios Bafitis, Christodoulos Keskinis, Foteini Katsikogianni, Ioannis Katsaros, Miltos K Lazarides, Efstratios Georgakarakos
BACKGROUND: The objective of this survey was to document and analyze the teaching methods of vascular surgery (VS) in the undergraduate curricula of the seven Greek medical schools. METHODS: The type of VS subject (core, selective, integrated in other subject), the type of clinical practice, and the specialty of the VS tutors were recorded from the curriculum of each medical school, as documented online. The information was cross-checked with the academic tutors of each Medical School via phone contact and verified by ten medical students of Medical School...
January 31, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28134542/time-on-your-hands-perceived-duration-of-sensory-events-is-biased-toward-concurrent-actions
#17
Daniel Yon, Rosanna Edey, Richard B Ivry, Clare Press
Perceptual systems must rapidly generate accurate representations of the world from sensory inputs that are corrupted by internal and external noise. We can typically obtain more veridical representations by integrating information from multiple channels, but this integration can lead to biases when inputs are, in fact, not from the same source. Although a considerable amount is known about how different sources of information are combined to influence what we perceive, it is not known whether temporal features are combined...
February 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28132396/expert-knowledge-influences-decision-making-for-couples-receiving-positive-prenatal-chromosomal-microarray-testing-results
#18
M A Rubel, A Werner-Lin, F K Barg, B A Bernhardt
To assess how participants receiving abnormal prenatal genetic testing results seek information and understand the implications of results, 27 US female patients and 12 of their male partners receiving positive prenatal microarray testing results completed semi-structured phone interviews. These interviews documented participant experiences with chromosomal microarray testing, understanding of and emotional response to receiving results, factors affecting decision-making about testing and pregnancy termination, and psychosocial needs throughout the testing process...
January 28, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28129065/neural-oscillations-and-a-nascent-corticohippocampal-theory-of-reference
#19
Mante S Nieuwland, Andrea E Martin
The ability to use words to refer to the world is vital to the communicative power of human language. In particular, the anaphoric use of words to refer to previously mentioned concepts (antecedents) allows dialogue to be coherent and meaningful. Psycholinguistic theory posits that anaphor comprehension involves reactivating a memory representation of the antecedent. Whereas this implies the involvement of recognition memory or the mnemonic subroutines by which people distinguish old from new, the neural processes for reference resolution are largely unknown...
January 27, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28125585/the-flash-lag-effect-as-a-motion-based-predictive-shift
#20
Mina A Khoei, Guillaume S Masson, Laurent U Perrinet
Due to its inherent neural delays, the visual system has an outdated access to sensory information about the current position of moving objects. In contrast, living organisms are remarkably able to track and intercept moving objects under a large range of challenging environmental conditions. Physiological, behavioral and psychophysical evidences strongly suggest that position coding is extrapolated using an explicit and reliable representation of object's motion but it is still unclear how these two representations interact...
January 2017: PLoS Computational Biology
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