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https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#1
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474652/monitoring-quality-of-care-in-acute-myocardial-infarction-patients-using-retrospective-registry-data
#2
Giovanni Veronesi, Antonella Zambon, John F Beltrame, Francesco Gianfagna, Giovanni Corrao, Marco M Ferrario
Background: Hospital-based registries provide a key contribution in assessing the quality of care in acute myocardial infarction (MI) patients, although some concern on selection bias of included cases has recently arisen. We investigated the feasibility of a retrospective, population-based registry of MIs in monitoring the quality of care. Methods: We identified all the hospitalizations with a diagnosis of acute MI among 35-79 years old residents in the Varese province, Northern Italy, in 2007-2008...
February 21, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29474554/rim-domain-loops-of-staphylococcal-%C3%AE-pore-forming-bi-component-toxin-s-components-recognize-target-human-erythrocytes-in-a-coordinated-manner
#3
Zhao Peng, Miyu Takeshita, Nao Shibata, Hideaki Tada, Yoshikazu Tanaka, Jun Kaneko
Staphylococcus aureus bi-component pore-forming toxins consist of S- and F-components, and form hetero-octameric beta-barrel pores on target blood cell membranes. Among them, γ-hemolysin (Hlg2 and LukF) and LukED (LukE and LukD) possess hemolytic activity, whereas the Panton -Valentine leukocidin (LukS-PV and LukF-PV) does not lyse human erythrocytes.Here, we focused on four loop structures in the rim domain of S-component, namely loops -1, -2, -3, and -4, and found that replacement of loop-4 in both Hlg2 and LukE with that of LukS-PV abolished their hemolytic activity...
February 17, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29474355/assessing-shortfalls-and-complementary-conservation-areas-for-national-plant-biodiversity-in-south-korea
#4
Hyeyeong Choe, James H Thorne, Patrick R Huber, Dongkun Lee, James F Quinn
Protected areas (PAs) are often considered the most important biodiversity conservation areas in national plans, but PAs often do not represent national-scale biodiversity. We evaluate the current conservation status of plant biodiversity within current existing PAs, and identify potential additional PAs for South Korea. We modeled species ranges for 2,297 plant species using Multivariate Adaptive Regression Splines and compared the level of mean range representation in South Korea's existing PAs, which comprise 5...
2018: PloS One
https://www.readbyqxmd.com/read/29474211/cdc-s-6-18-initiative-a-cross-sector-approach-to-translating-evidence-into-practice
#5
Laura C Seeff, Tricia McGinnis, Hilary Heishman
CONTEXT: As the US health care system continues to undergo dynamic change, the increased alignment between health care quality and payment has provided new opportunities for public health and health care sectors to work together. PROGRAM: The Centers for Disease Control and Prevention's 6|18 Initiative accelerates cross-sector collaboration between public health and health care purchasers, payers, and providers and highlights 6 high-burden conditions and 18 associated interventions with evidence of cost reduction/neutrality and improved health outcomes...
February 22, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29473918/metal-nanoparticles-porous-silicon-microcavity-enhanced-surface-plasmon-resonance-fluorescence-for-the-detection-of-dna
#6
Jiajia Wang, Zhenhong Jia
A porous silicon microcavity (PSiMC) with resonant peak wavelength of 635 nm was fabricated by electrochemical etching. Metal nanoparticles (NPs)/PSiMC enhanced fluorescence substrates were prepared by the electrostatic adherence of Au NPs that were distributed in PSiMC. The Au NPs/PSiMC device was used to characterize the target DNA immobilization and hybridization with its complementary DNA sequences marked with Rhodamine red (RRA). Fluorescence enhancement was observed on the Au NPs/PSiMC device substrate; and the minimum detection concentration of DNA ran up to 10 pM...
February 23, 2018: Sensors
https://www.readbyqxmd.com/read/29473733/%C3%AE-l-threose-nucleic-acids-as-biocompatible-antisense-oligonucleotides-for-suppressing-gene-expression-in-living-cells
#7
Ling Sum Liu, Hoi Man Leung, Dick Yan Tam, Tsz Wan Lo, Sze Wing Wong, Pik Kwan Lo
Due to the chemical simplicity of α- L-Threose nucleic acid (TNA) and its ability to exchange genetic information between itself and RNA, it has been raised significant interests in TNA as RNA ancestor. We herein explore the biological properties and evaluate the potency of sequence-designed TNA polymers to suppress gene expression in living environments. We found that sequence-specific TNA macromolecules exhibit strong affinity and specificity towards the complementary RNA targets, are highly biocompatible and non-toxic in living cell system, and readily enter a number of cell lines without using transfecting agents...
February 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29473702/dual-c-sp3-h-bond-functionalization-of-n-heterocycles-via-visible-light-photocatalyzed-dehydrogenation-2-2-cycloaddition-sequential-reaction
#8
Guo-Qiang Xu, Ji-Tao Xu, Zhi-Tao Feng, Hui Liang, Zhu-Yin Wang, Yong Qin, Peng-Fei Xu
Here we describe a mild method to achieve dual C(sp3)-H bond functionalization of saturated nitrogen-containing heterocycles via a sequential visible-light photocatalyzed dehydrogenation/[2+2] cycloaddition procedure. As a complementary approach to the well-established iminium ion and α-amino radical intermediates, the elusive cyclic enamine intermediates are effectively generated via photoredox catalysis under mild conditions, which are efficiently captured by acetylene ester to form a wide array of bicyclic amino acid derivatives and realize the simultaneous functionalization of two vicinal C(sp3)-H bonds...
February 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29473382/a-randomized-multicenter-controlled-study-comparing-efficacy-and-safety-of-a-new-complementary-and-alternative-medicine-cam-versus-solifenacin-succinate-in-women-with-overactive-bladder-syndrome
#9
Carlo Vecchioli-Scaldazza, Carolina Morosetti, Serena Maruccia, Stefano Casellato, Wilma Rociola, Ester Illiano, Francesco Garofalo
INTRODUCTION: To assess efficacy and tolerability of a new complementary and alternative medicine (CAM) consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum capsicatum) and amino acid L-Glutammina, in the treatment of female Overactive Bladder syndrome (OAB). MATERIALS AND METHODS: 90 consecutive women with OAB symptoms were enrolled in this prospective, randomized, controlled study. Women were divided randomly into two groups of 45 patients each...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473324/establishment-and-characterization-of-in-vivo-orthotopic-bioluminescent-xenograft-models-from-human-osteosarcoma-cell-lines-in-swiss-nude-and-nsg-mice
#10
Maria Eugenia Marques da Costa, Estelle Daudigeos-Dubus, Anne Gomez-Brouchet, Olivia Bawa, Valerie Rouffiac, Massimo Serra, Katia Scotlandi, Conceição Santos, Birgit Geoerger, Nathalie Gaspar
Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the main therapeutic challenge. New drug evaluation to improve patient survival requires the development of various preclinical models mimicking at best the complexity of the disease and its metastatic potential. We describe here the development and characteristics of two orthotopic bioluminescent (Luc/mKate2) cell-derived xenograft (CDX) models, Saos-2-B-Luc/mKate2-CDX and HOS-Luc/mKate2-CDX, in different immune (nude and NSG mouse strains) and bone (intratibial and paratibial with periosteum activation) contexts...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473236/oxide-thin-film-electronics-using-all-mxene-electrical-contacts
#11
Zhenwei Wang, Hyunho Kim, Husam N Alshareef
2D MXenes have shown great promise in electrochemical and electromagnetic shielding applications. However, their potential use in electronic devices is significantly less explored. The unique combination of metallic conductivity and hydrophilic surface suggests that MXenes can also be promising in electronics and sensing applications. Here, it is shown that metallic Ti3 C2 MXene with work function of 4.60 eV can make good electrical contact with both zinc oxide (ZnO) and tin monoxide (SnO) semiconductors, with negligible band offsets...
February 23, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29473091/mechanisms-through-which-supportive-relationships-with-parents-and-peers-mitigate-victimization-depression-and-internalizing-problems-in-children-bullied-by-peers
#12
K L Healy, M R Sanders
This study investigated how supportive relationships with peers and parents protect children against ongoing victimization, internalizing problems and depression. The longitudinal data set tracked progress of 111 children recruited for the trial of Resilience Triple P, and previously bullied by peers. Informants included children, parents and teachers. Higher levels of facilitative parenting (warm parenting that supports peer relationships) and peer acceptance predicted lower later levels of both depression and victimization over time...
February 22, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29472940/inheritance-and-linkage-of-virulence-genes-in-chinese-predominant-race-cyr32-of-the-wheat-stripe-rust-pathogen-puccinia-striiformis-f-sp-tritici
#13
Long Wang, Dan Zheng, Shuxia Zuo, Xianming Chen, Hua Zhuang, Lili Huang, Zhensheng Kang, Jie Zhao
Puccinia striiformis f.sp. tritici ( Pst ) is the causal agent of stripe (yellow) rust on wheat. It seriously threatens wheat production worldwide. The obligate biotrophic fungus is highly capable of producing new virulent races that can overcome resistance. Studying the inheritance of Pst virulence using the classical genetic approach was not possible until the recent discovery of its sexual stage on barberry plants. In the present study, 127 progeny isolates were obtained by selfing a representative Chinese Yellow Rust (CYR) race, CYR32, on Berberis aggregate ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29472919/in-the-absence-of-central-pre-b-cell-receptor-selection-peripheral-selection-attempts-to-optimize-the-antibody-repertoire-by-enriching-for-cdr-h3-y101
#14
Mohamed Khass, Tessa Blackburn, Ada Elgavish, Peter D Burrows, Harry W Schroeder
Sequential developmental checkpoints are used to "optimize" the B cell antigen receptor repertoire by minimizing production of autoreactive or useless immunoglobulins and enriching for potentially protective antibodies. The first and apparently most impactful checkpoint requires μHC to form a functional pre-B cell receptor (preBCR) by associating with surrogate light chain, which is composed of VpreB and λ5. Absence of any of the preBCR components causes a block in B cell development that is characterized by severe immature B cell lymphopenia...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472594/association-between-autonomic-control-indexes-and-mortality-in-subjects-admitted-to-intensive-care-unit
#15
Alberto Porta, Riccardo Colombo, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Giovanni Ranuzzi, Stefano Guzzetti, Tommaso Fossali, Ferdinando Raimondi
This study checks whether autonomic markers derived from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) and from their interactions with spontaneous or mechanical respiration (R) are associated with mortality in patients admitted to intensive care unit (ICU). Three-hundred consecutive HP, SAP and R values were recorded during the first day in ICU in 123 patients. Population was divided into survivors (SURVs, n = 83) and non-survivors (NonSURVs, n = 40) according to the outcome...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472557/metformin-exerts-multitarget-antileukemia-activity-in-jak2-v617f-positive-myeloproliferative-neoplasms
#16
João Agostinho Machado-Neto, Bruna Alves Fenerich, Renata Scopim-Ribeiro, Christopher A Eide, Juan Luiz Coelho-Silva, Carlos Roberto Porto Dechandt, Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, Priscila Santos Scheucher, Belinda Pinto Simões, Luciane Carla Alberici, Lorena Lôbo de Figueiredo Pontes, Cristina E Tognon, Brian J Druker, Eduardo Magalhães Rego, Fabiola Traina
The recurrent gain-of-function JAK2V617F mutation confers growth factor-independent proliferation for hematopoietic cells and is a major contributor to the pathogenesis of myeloproliferative neoplasms (MPN). The lack of complete response in most patients treated with the JAK1/2 inhibitor ruxolitinib indicates the need for identifying novel therapeutic strategies. Metformin is a biguanide that exerts selective antineoplastic activity in hematological malignancies. In the present study, we investigate and compare effects of metformin and ruxolitinib alone and in combination on cell signaling and cellular functions in JAK2V617F -positive cells...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29472540/exploiting-genetic-variation-to-uncover-rules-of-transcription-factor-binding-and-chromatin-accessibility
#17
Vivek Behera, Perry Evans, Carolyne J Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A Keller, Belinda Giardine, Kai Tan, Ross C Hardison, Junwei Shi, Gerd A Blobel
Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid cell lines. The impact of discriminatory single-nucleotide variants on TF ChIP signal enables definition at single base resolution of in vivo binding characteristics of nuclear factors GATA1, TAL1, and CTCF...
February 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29472300/an-automated-statistical-technique-for-counting-distinct-multiple-sclerosis-lesions
#18
J D Dworkin, K A Linn, I Oguz, G M Fleishman, R Bakshi, G Nair, P A Calabresi, R G Henry, J Oh, N Papinutto, D Pelletier, W Rooney, W Stern, N L Sicotte, D S Reich, R T Shinohara
BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with clinical outcome. Lesion count, which encapsulates the natural history of lesion formation and is thought to provide complementary information, is difficult to assess in patients with confluent (ie, spatially overlapping) lesions. We introduce a statistical technique for cross-sectionally counting pathologically distinct lesions. MATERIALS AND METHODS: MR imaging was used to assess the probability of a lesion at each location...
February 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29472284/symbiosis-in-the-microbial-world-from-ecology-to-genome-evolution
#19
REVIEW
Jean-Baptiste Raina, Laura Eme, F Joseph Pollock, Anja Spang, John M Archibald, Tom A Williams
The concept of symbiosis - defined in 1879 by de Bary as 'the living together of unlike organisms' - has a rich and convoluted history in biology. In part, because it questioned the concept of the individual, symbiosis fell largely outside mainstream science and has traditionally received less attention than other research disciplines. This is gradually changing. In nature organisms do not live in isolation but rather interact with, and are impacted by, diverse beings throughout their life histories. Symbiosis is now recognized as a central driver of evolution across the entire tree of life, including, for example, bacterial endosymbionts that provide insects with vital nutrients and the mitochondria that power our own cells...
February 22, 2018: Biology Open
https://www.readbyqxmd.com/read/29471828/a-delphi-study-and-ranking-exercise-to-support-commissioning-services-future-delivery-of-thrombectomy-services-in-england
#20
Kristoffer Halvorsrud, Darren Flynn, Gary A Ford, Peter McMeekin, Ajay Bhalla, Joyce Balami, Dawn Craig, Phil White
BACKGROUND: Intra-arterial thrombectomy is the gold standard treatment for large artery occlusive stroke. However, the evidence of its benefits is almost entirely based on trials delivered by experienced neurointerventionists working in established teams in neuroscience centres. Those responsible for the design and prospective reconfiguration of services need access to a comprehensive and complementary array of information on which to base their decisions. This will help to ensure the demonstrated effects from trials may be realised in practice and account for regional/local variations in resources and skill-sets...
February 22, 2018: BMC Health Services Research
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