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https://www.readbyqxmd.com/read/28655215/development-of-a-new-method-based-on-unmodified-gold-nanoparticles-and-peptide-nucleic-acids-for-detecting-bovine-viral-diarrhea-virus-rna
#1
Maryam Askaravi, Seyedeh Elham Rezatofighi, Saadat Rastegarzadeh, Masoud Reza Seifi Abad Shapouri
A simple colorimetric assay is presented for detecting bovine viral diarrhea virus (BVDV)-RNA based on aggregation of gold nanoparticles (AuNPs) in the presence of charge-neutral peptide nucleic acids (PNA). Free charge-neutral PNA oligomers tended to be adsorbed onto AuNPs and act as a coagulant, whereas hybridizing complementary RNA with PNA disrupted PNA-induced AuNP aggregation, and the NPs remained stable. However, non-complementary RNA did not have this effect, and PNA induced aggregation of the AuNPs that resulted in a color change of the reaction from red to blue...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28655165/investigation-of-natural-radioactivity-as-a-possible-driver-of-cancer-incidence-in-para%C3%A3-ba-northeastern-brazil
#2
Josineide Marques do Nascimento Santos, José Araújo Dos Santos Júnior, Ana Maria Mendoça de Albuquerque Melo, Romilton Dos Santos Amaral, Rômulo Simões Cezar Menezes, Zahily Herrero Fernández, Lino Angel Valcárcel Rojas, Jairo Dias Bezerra, Alberto Antônio da Silva, Kennedy Francys Rodrigues Damascena, Nilson Vicente da Silva Medeiros
An increase of health problems has been reported in the city of Triunfo, Paraíba, NE Brazil. This pattern has been attributed to environmental radiation since there are uranium deposits in the neighboring municipalities. The present study aimed to carry a radiometric survey in Triunfo to determine effective dose from external outdoor radiation exposure. The results were obtained through 'in situ' measurements using a gamma spectrometry system. The results ranged from 0.06 to 0.38 mSv/y, mean of 0.20 mSv/y...
June 24, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28655145/partitioned-learning-of-deep-boltzmann-machines-for-snp-data
#3
Moritz Hess, Stefan Lenz, Tamara J Blätte, Lars Bullinger, Harald Binder
Motivation: Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been applied to single nucleotide polymorphism (SNP) data, probably due to the high number of features typically exceeding the number of studied individuals. Results: After a brief overview of how deep Boltzmann machines (DBMs), a deep learning approach, can be adapted to SNP data in principle, we specifically present a way to alleviate the dimensionality problem by partitioned learning...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28654744/mimicking-enzyme-based-colorimetric-aptasensor-for-antibiotic-residue-detection-in-milk-combining-magnetic-loop-dna-probes-and-cha-assisted-target-recycling-amplification
#4
Qian Luan, Ning Gan, Yuting Cao, Tianhua Li
A mimicking enzyme-based colorimetric aptasensor was developed for the detection of kanamycin (KANA) in milk using magnetic loop-DNA-NMOF-Pt (m-L-DNA) probes and catalytic hairpin assembly (CHA)-assisted target recycling for signal amplification. The m-L-DNA probes were constructed via hybridization of hairpin DNA H1 (containing aptamer sequence) immobilized magnetic beads (m-H1) and signal DNA (sDNA, partial hybridization with H1) labeled nano Fe-MIL-88NH2-Pt (NMOF-Pt-sDNA). In the presence of KANA and complementary hairpin DNA H2, the m-L-DNA probes decomposed and formed an m-H1/KANA intermediate, which triggered the CHA reaction to form a stable duplex strand (m-H1-H2) while releasing KANA again for recycling...
June 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28654725/searching-online-mendelian-inheritance-in-man-omim-a-knowledgebase-of-human-genes-and-genetic-phenotypes
#5
Joanna S Amberger, Ada Hamosh
Online Mendelian Inheritance in Man (OMIM) at OMIM.org is the primary repository of comprehensive, curated information on genes and genetic phenotypes and the relationships between them. This unit provides an overview of the types of information in OMIM and optimal strategies for searching and retrieving the information. OMIM.org has links to many related and complementary databases, providing easy access to more information on a topic. The relationship between genes and genetic disorders is highlighted in this unit...
June 27, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28654419/affimers-proteins-are-versatile-and-renewable-affinity-reagents
#6
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca Ross, Danah AlQallaf, Ashley Pe Roberts, Alexander Balls, Alistair Curd, Ruth E Hughes, Heather Martin, Sarah R Needham, Laura C Zanetti-Domingues, Yashar Sadigh, Thomas P Peacock, Anna A Tang, Naomi Gibson, Hannah Kyle, Geoffrey W Platt, Nicola Ingram, Thomas Taylor, Louise P Coletta, Iain Manfield, Margaret Knowles, Sandra Bell, Filomena Esteves, Azhar Maqbool, Raj K Prasad, Mark Drinkhill, Robin S Bon, Vikesh Patel, Sarah A Goodchild, Marisa Martin-Fernandez, Ray J Owens, Joanne E Nettleship, Michael E Webb, Michael Harrison, Jonathan D Lippiat, Sreenivasan Ponnambalam, Michelle Peckham, Alastair Smith, Paul Ko Ferrigno, Matt Johnson, Michael J McPherson, Darren Charles Tomlinson
Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many show excellent performance, although some are poorly characterised or have stability or batch variability issues, supporting the use of alternative binding proteins as complementary reagents for many applications. Here we report on the use of Affimer proteins as research reagents...
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28654379/multimodal-imaging-of-patients-with-gliomas-confirms-11-c-met-pet-as-a-complementary-marker-to-mri-for-noninvasive-tumor-grading-and-intraindividual-follow-up-after-therapy
#7
Kai R Laukamp, Florian Lindemann, Matthias Weckesser, Volker Hesselmann, Sandra Ligges, Johannes Wölfer, Astrid Jeibmann, Bastian Zinnhardt, Thomas Viel, Michael Schäfers, Werner Paulus, Walter Stummer, Otmar Schober, Andreas H Jacobs
The value of combined L-( methyl-[(11)C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated. In n = 65 patients with histologically verified brain lesions n = 70 MET-PET and MRI (T1-weighted gadolinium-enhanced [T1w-Gd] and fluid-attenuated inversion recovery or T2-weighted [FLAIR/T2w]) examinations were performed. The computer software "visualization and analysis framework volume rendering engine (Voreen)" was used for analysis of extent and intersection of tumor compartments...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654244/monolithically-integrated-flexible-black-phosphorus-complementary-inverter-circuits
#8
Yuanda Liu, Kah-Wee Ang
Two-dimensional (2D) inverter is a fundamental building block for flexible logic circuit which has previously been realized by heterogeneously wiring transistors with two discrete channel materials. Here, we demonstrate a monolithically integrated complementary inverter made using a homogenous black phosphorus (BP) nanosheet on flexible substrates. The digital logic inverter circuit is demonstrated via effective threshold voltage tuning within a single BP material, which offers both electron and hole dominated conducting channels with nearly symmetric pinch-off and current saturation...
June 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28654170/from-electrons-and-nuclei-to-assemblies-of-correlated-atoms
#9
Neil W Ashcroft
What constitutes an atom? The answer may depend on whether you ask a physicist or a chemist. But the complementary views lead to productive overlap in atomic theory. Limiting cases, under high pressures and temperatures, have had a profound impact in a wider context.
June 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28654122/dissipation-of-self-assemblies-by-fusion-of-complementary-gels-an-elegant-strategy-for-programmed-enzymatic-reactions
#10
Deep Mandal, Pritam Choudhury, Deblina Sarkar, Prasanta Kumar Das
Cholesterol based phenylboronic acid and glucose tailored complementary gels were developed which underwent mutual self-destruction upon mixing due to the formation of a boronate-diol adduct. This dissipation of the complementary gels was employed in a programmed enzymatic reaction and in pro-drug activation.
June 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28654081/aging-affects-the-balance-of-neural-entrainment-and-top-down-neural-modulation-in-the-listening-brain
#11
Molly J Henry, Björn Herrmann, Dunja Kunke, Jonas Obleser
Healthy aging is accompanied by listening difficulties, including decreased speech comprehension, that stem from an ill-understood combination of sensory and cognitive changes. Here, we use electroencephalography to demonstrate that auditory neural oscillations of older adults entrain less firmly and less flexibly to speech-paced (∼3 Hz) rhythms than younger adults' during attentive listening. These neural entrainment effects are distinct in magnitude and origin from the neural response to sound per se...
June 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28654080/studying-cell-cycle-regulated-gene-expression-by-two-complementary-cell-synchronization-protocols
#12
Aintzane Apraiz, Jone Mitxelena, Ana Zubiaga
The gene expression program of the cell cycle represents a critical step for understanding cell cycle-dependent processes and their role in diseases such as cancer. Cell cycle-regulated gene expression analysis depends on cell synchronization into specific phases. Here we describe a method utilizing two complementary synchronization protocols that is commonly used for studying periodic variation of gene expression during the cell cycle. Both procedures are based on transiently blocking the cell cycle in one defined point...
June 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654071/protocols-for-c-brick-dna-standard-assembly-using-cpf1
#13
Shi-Yuan Li, Guo-Ping Zhao, Jin Wang
CRISPR-associated protein Cpf1 cleaves double-stranded DNA under the guidance of CRISPR RNA (crRNA), generating sticky ends. Because of this characteristic, Cpf1 has been used for the establishment of a DNA assembly standard called C-Brick, which has the advantage of long recognition sites and short scars. On a standard C-Brick vector, there are four Cpf1 recognition sites - the prefix (T1 and T2 sites) and the suffix (T3 and T4 sites) - flanking biological DNA parts. The cleavage of T2 and T3 sites produces complementary sticky ends, which allow for the assembly of DNA parts with T2 and T3 sites...
June 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653907/olfactory-receptor-neurons-use-gain-control-and-complementary-kinetics-to-encode-intermittent-odorant-stimuli
#14
Srinivas Gorur-Shandilya, Mahmut Demir, Junjiajia Long, Damon A Clark, Thierry Emonet
Insects find food and mates by navigating odorant plumes that can be highly intermittent, with intensities and durations that vary rapidly over orders of magnitude. Much is known about olfactory responses to pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs) detect the intensity and timing of natural stimuli, where the absence of scale in the signal makes detection a formidable olfactory task. By stimulating Drosophila ORNs in vivo with naturalistic and Gaussian stimuli, we show that ORNs adapt to stimulus mean and variance, and that adaptation and saturation contribute to naturalistic sensing...
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28653798/spinal-cord-injury-pain-instrument-and-paindetect-questionnaire-convergent-construct-validity-in-individuals-with-spinal-cord-injury
#15
S Franz, C Schuld, E P Wilder-Smith, L Heutehaus, S Lang, S Gantz, S Schuh-Hofer, R-D Treede, T N Bryce, H Wang, N Weidner
BACKGROUND: Neuropathic pain (NeuP) is a frequent sequel of spinal cord injury (SCI). The SCI Pain Instrument (SCIPI) was developed as a SCI-specific NeuP screening tool. A preliminary validation reported encouraging results requiring further evaluation in terms of psychometric properties. The painDETECT questionnaire (PDQ), a commonly applied NeuP assessment tool, was primarily validated in German, but not specifically developed for SCI and not yet validated according to current diagnostic guidelines...
June 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28652643/hybrid-tandem-quantum-dot-organic-photovoltaic-cells-with-complementary-near-infrared-absorption
#16
Taesoo Kim, Elenita Palmiano, Ru-Ze Liang, Hanlin Hu, Banavoth Murali, Ahmad R Kirmani, Yuliar Firdaus, Yangqin Gao, Arif Sheikh, Mingjian Yuan, Omar F Mohammed, Sjoerd Hoogland, Pierre M Beaujuge, Edward H Sargent, Aram Amassian
Monolithically integrated hybrid tandem solar cells that effectively combine solution-processed colloidal quantum dot (CQD) and organic bulk heterojunction subcells to achieve tandem performance that surpasses the individual subcell efficiencies have not been demonstrated to date. In this work, we demonstrate hybrid tandem cells with a low bandgap PbS CQD subcell harvesting the visible and near-infrared photons and a polymer:fullerene-poly (diketopyrrolopyrrole-terthiophene) (PDPP3T):[6,6]-phenyl-C60-butyric acid methyl ester (PC61BM)-top cell absorbing effectively the red and near-infrared photons of the solar spectrum in a complementary fashion...
May 29, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28652586/network-model-predicts-that-catsper-is-the-main-ca-2-channel-in-the-regulation-of-sea-urchin-sperm-motility
#17
Jesús Espinal-Enríquez, Daniel Alejandro Priego-Espinosa, Alberto Darszon, Carmen Beltrán, Gustavo Martínez-Mekler
Spermatozoa sea urchin swimming behaviour is regulated by small peptides from the egg outer envelope. Speract, such a peptide, after binding to its receptor in Strongylocentrotus purpuratus sperm flagella, triggers a signaling pathway that culminates with a train of intracellular calcium oscillations, correlated with changes in sperm swimming pattern. This pathway has been widely studied but not fully characterized. Recent work on Arbacia punctulata sea urchin spermatozoa has documented the presence of the Ca(2+) CatSper channel in their flagella and its involvement in chemotaxis...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652396/tlr7-signaling-regulates-th17-cells-and-autoimmunity-novel-potential-for-autoimmune-therapy
#18
Jian Ye, Yadan Wang, Xia Liu, Lingyun Li, Adeleye Opejin, Eddy C Hsueh, Huanle Luo, Tian Wang, Daniel Hawiger, Guangyong Peng
Innate regulation through TLR signaling has been shown to be important for promoting T cell subset development and function. However, limited information is known about whether differential TLR signaling can selectively inhibit Th17 and/or Th1 cells, which are important for controlling excessive inflammation and autoimmune responses. In this article, we demonstrate that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells...
June 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28652395/differential-requirements-for-tcf1-long-isoforms-in-cd8-and-cd4-t-cell-responses-to-acute-viral-infection
#19
Jodi A Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng, Weiqun Peng, Vladimir P Badovinac, John T Harty, Hai-Hui Xue
In response to acute viral infection, activated naive T cells give rise to effector T cells that clear the pathogen and memory T cells that persist long-term and provide heightened protection. T cell factor 1 (Tcf1) is essential for several of these differentiation processes. Tcf1 is expressed in multiple isoforms, with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a unique N-terminal β-catenin-interacting domain. In this study, we specifically ablated Tcf1 long isoforms in mice, while retaining expression of Tcf1 short isoforms...
June 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28652373/materials-and-processing-approaches-for-foundry-compatible-transient-electronics
#20
Jan-Kai Chang, Hui Fang, Christopher A Bower, Enming Song, Xinge Yu, John A Rogers
Foundry-based routes to transient silicon electronic devices have the potential to serve as the manufacturing basis for "green" electronic devices, biodegradable implants, hardware secure data storage systems, and unrecoverable remote devices. This article introduces materials and processing approaches that enable state-of-the-art silicon complementary metal-oxide-semiconductor (CMOS) foundries to be leveraged for high-performance, water-soluble forms of electronics. The key elements are (i) collections of biodegradable electronic materials (e...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
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