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https://www.readbyqxmd.com/read/28241356/testosterone-treatment-and-cognitive-function-in-older-men-with-low-testosterone-and-age-associated-memory-impairment
#1
Susan M Resnick, Alvin M Matsumoto, Alisa J Stephens-Shields, Susan S Ellenberg, Thomas M Gill, Sally A Shumaker, Debbie D Pleasants, Elizabeth Barrett-Connor, Shalender Bhasin, Jane A Cauley, David Cella, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, John T Farrar, Cora E Lewis, Mark E Molitch, Marco Pahor, Ronald S Swerdloff, Denise Cifelli, Stephen Anton, Shehzad Basaria, Susan J Diem, Christina Wang, Xiaoling Hou, Peter J Snyder
Importance: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. Objective: To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI). Design, Setting, and Participants: The Testosterone Trials (TTrials) were 7 trials to assess the efficacy of testosterone treatment in older men with low testosterone levels...
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28241355/testosterone-treatment-and-coronary-artery-plaque-volume-in-older-men-with-low-testosterone
#2
Matthew J Budoff, Susan S Ellenberg, Cora E Lewis, Emile R Mohler, Nanette K Wenger, Shalender Bhasin, Elizabeth Barrett-Connor, Ronald S Swerdloff, Alisa Stephens-Shields, Jane A Cauley, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, Thomas M Gill, Alvin M Matsumoto, Mark E Molitch, Rine Nakanishi, Negin Nezarat, Suguru Matsumoto, Xiaoling Hou, Shehzad Basaria, Susan J Diem, Christina Wang, Denise Cifelli, Peter J Snyder
Importance: Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk. Objective: To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume. Design, Setting, and Participants: Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014...
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28239637/alzheimer-s-disease-the-influence-of-age-on-clinical-heterogeneity-through-the-human-brain-connectome
#3
Bradford C Dickerson, Michael Brickhouse, Scott McGinnis, David A Wolk
INTRODUCTION: One major factor that influences the heterogeneity of Alzheimer's disease (AD) is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that this age-related heterogeneity can be understood better by considering age-related differences in atrophy in the context of large-scale brain networks subserving cognitive functions that contribute to memory. METHODS: We examined data from 75 patients with mild AD dementia from Alzheimer's Disease Neuroimaging Initiative...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28238673/bisphosphonate-use-after-hip-fracture-in-older-adults-a%C3%A2-nationwide-retrospective-cohort-study
#4
Peter Nordström, Annika Toots, Yngve Gustafson, Karl-Göran Thorngren, Ami Hommel, Anna Nordström
OBJECTIVES: The aim of this study was to investigate the association between bisphosphonate use and the risk of new fracture in a nationwide cohort of individuals with previous hip fractures, with emphasis on individuals above 80 years of age. DESIGN, SETTING, AND PARTICIPANTS: From a nationwide cohort with hip fracture (2006-2012) (n = 93, 601), each individual prescribed bisphosphonates after hip fracture (n = 5845) was matched with up to three individuals not prescribed bisphosphonates, resulting in a cohort of 21,363 individuals...
February 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28238199/increased-number-of-community-living-older-adults-attending-an-emergency-department-with-falls-and-fractures-north-dublin-experience
#5
C W Fan, J Duggan, D Rodger, E Brazil, F McCarthy
BACKGROUND: The number of attendances to emergency department (ED) due to falls and fractures increases as the population ages. The community-based falls prevention strategy may reduce the number of falls requiring medical attention. AIM: Our aim was to determine the changes over time in community-living older adults on the number of attendances to an urban ED over a 5 year period. METHODS: Community-living adults aged ≥65 years from a catchment attending with falls and fractures to an ED in 2010 and 2014 were identified through an electronic patient record...
February 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28236586/impaired-mobility-depressed-mood-cognitive-impairment-and-polypharmacy-are-independently-associated-with-disability-in-older-cancer-outpatients-the-prospective-physical-frailty-in-elderly-cancer-patients-pf-ec-cohort-study
#6
Frederic Pamoukdjian, Thomas Aparicio, Laurent Zelek, Marouane Boubaya, Philippe Caillet, Veronique François, Laure de Decker, Vincent Lévy, Georges Sebbane, Elena Paillaud
OBJECTIVE: To assess the prevalence of disability and the oncologic factors associated with disability in older outpatients with cancer. MATERIALS AND METHODS: The Physical Frailty in Elderly Cancer patients (PF-EC) study (France) is a prospective bicentric observational cohort study. Two hundred and ninety outpatients with cancer were included. A cross-sectional analysis of oncologic factors and geriatric variables associated with disability that were collected using a comprehensive geriatric assessment (CGA) was conducted...
February 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28236456/outcomes-after-percutaneous-coronary-intervention-of-acute-coronary-syndrome-complicated-with-cardiopulmonary-arrest-from-a-japanese-multicenter-registry
#7
Yohei Numasawa, Mitsuaki Sawano, Hiroaki Miyata, Ikuko Ueda, Shigetaka Noma, Masahiro Suzuki, Toshiki Kuno, Masaki Kodaira, Yuichiro Maekawa, Keiichi Fukuda, Shun Kohsaka
Details on the characteristics and outcomes in patients with acute coronary syndrome (ACS) complicated with cardiopulmonary arrest (CPA) have been limited. We evaluated inhospital outcomes after percutaneous coronary intervention in these patients. From 2008 to 2014, 5,943 patients with ACS including 2,973 patients with ST-elevation myocardial infarction (STEMI) and 2,970 patients with non-STEMI or unstable angina (NSTE-ACS) were registered. In total, 264 patients experienced CPA within 24 hours of admission...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28231658/-relationship-between-reproductive-history-and-preterm-births-in-the-last-pregnancy-in-shaanxi-province
#8
B W Qin, J Ying, Q Lei, P F Qu, F L Lei, J M Li, H Yan
Objective: To analyze the incidence of preterm delivery among single live neonates and the association between maternal reproductive history and preterm birth. Methods: A questionnaire survey was conducted on reproductive history among women at childbearing age who were selected through multi-stage stratified random sampling method in Shaanxi, during 2010-2013. Samples would include women at childbearing age and in pregnancy or having had definite pregnancy outcomes. Results: A total of 29 608 women at childbearing age with their infants, were studied...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28230421/medicare-expenditure-correlates-of-atrophy-and-cerebrovascular-disease-in-older-adults
#9
Briana S Last, Maria-José García Rubio, Carolyn W Zhu, Stephanie Cosentino, Jennifer J Manly, Charles DeCarli, Yaakov Stern, Adam M Brickman
: Background/Study Context: Magnetic resonance imaging (MRI) markers of cerebrovascular disease and atrophy are common in older adults and are associated with cognitive and medical burden. However, the extent to which they are related to health care expenditures has not been examined. We studied whether increased Medicare expenditures were associated with brain markers of atrophy and cerebrovascular disease in older adults. METHODS: A subset of participants (n = 592; mean age = 80 years; 66% women) from the Washington Heights Inwood Columbia Aging Project (WHICAP), a community-based observational study of aging in upper Manhattan, received high-resolution MRI and had Medicare expenditure data on file...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28230419/the-association-between-physical-performance-and-executive-function-in-a-sample-of-rural-older-adults-from-south-carolina-usa
#10
Ryan S Falck, Sara Wilcox, John R Best, Jessica L Chandler, Teresa Liu-Ambrose
BACKGROUND: Mobility and executive functions (EFs) decline with age, although associations between mobility and EFs are less clear. This study examined relationships between different mobility measures and EFs among rural older adults. METHODS: This cross-sectional study recruited 56 older adults (60+ years) in rural South Carolina. Mobility was assessed via gait speed, timed up-and-go, chair stand, and as a composite physical performance score (PPS). EFs was assessed via Trail Making Test, semantic fluency, and phonemic fluency...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28230301/social-participation-among-older-adults-not-engaged-in-full-or-part-time-work-is-associated-with-more-physical-activity-and-less-sedentary-time
#11
Hiroyuki Kikuchi, Shigeru Inoue, Noritoshi Fukushima, Tomoko Takamiya, Yuko Odagiri, Yumiko Ohya, Shiho Amagasa, Koichiro Oka, Neville Owen
AIM: Social participation provides health benefits for older adults. However, there is the need to identify whether higher social participation is associated with older adults being more physically active and less sedentary (sitting time). We examined the associations of social participation with physical activity, and sedentary time, in a population-based sample of older Japanese adults. METHODS: A population-based, cross-sectional mail survey carried out in 2010 was used to collect data on social participation, physical activity, sedentary time and sociodemographic characteristics...
February 23, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28229384/relationship-of-meteorological-factors-and-acute-stroke-events-in-kaunas-lithuania-in-2000-2010
#12
Laura Tamasauskiene, Daiva Rastenyte, Ricardas Radisauskas, Abdonas Tamosiunas, Domantas Tamasauskas, Vidmantas Vaiciulis, Daina Kranciukaite-Butylkiniene, Egle Milinaviciene
Some researchers have hypothesised that meteorological factors may have an impact on acute cerebrovascular diseases. The aim of this study was to determine an impact of some meteorological factors on occurrence of acute cerebrovascular events in the middle-aged Kaunas population. Kaunas stroke register data were used. Data on meteorological factors for the time period from 2000 to 2010 were obtained from the Lithuanian Hydrometeorological Service Kaunas Meteorological Station. We analysed 4038 cases with stroke...
February 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28224924/left-bundle-branch-block-in-patients-with-acute-myocardial-infarction-presentation-treatment-and-trends-in-outcome-from-1997-to-2016-in-routine-clinical-practice
#13
Paul Erne, Juan F Iglesias, Philip Urban, Franz R Eberli, Hans Rickli, René Simon, Thomas A Fischer, Dragana Radovanovic
BACKGROUND: Whether patients with acute myocardial infarction presenting with new or presumed new left bundle-branch block (LBBB) should be treated in the same way as those presenting with ST-elevation (STE) is still a matter of debate. METHODS: Data from 28,358 patients enrolled in AMIS Plus from 1997 to 2016 were analyzed to evaluate differences in treatment and outcome of patients presenting with LBBB (n=2295) or STE (n=26,090) on their initial electrocardiogram using descriptive statistics and multivariate logistic regression...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28222827/health-risk-appraisal-in-older-people-7-long-acting-benzodiazepine-use-in-community-dwelling-older-adults-in-london-is-it-related-to-physical-or-psychological-factors
#14
Devoshree Chatterjee, Steve Iliffe, Kalpa Kharicha, Danielle Harari, Cameron Swift, Gerhard Gillman, Andreas E Stuck
: Aim To investigate whether the use of long-acting benzodiazepines, in individuals aged 65 and over is mediated by physical or psychological factors. BACKGROUND: Long-acting benzodiazepine consumption among older people has implications for mortality, morbidity and cost-effective prescribing. Two models explain benzodiazepine use in this age group, one linked to physical illness and disability and one to psychological factors. METHODS: Secondary analysis of baseline data from a study of 1059 community-dwelling non-disabled people aged 65 years and over recruited from three general practices in London...
February 22, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28222583/evaluation-of-self-administered-versus-interviewer-administered-completion-of-edinburgh-claudication-questionnaire
#15
Bilgin B Basgoz, Ilker Tasci, Birol Yildiz, Cengizhan Acikel, Hasan K Kabul, Kenan Saglam
BACKGROUND: The aim of this study was to determine the impacts of different administration modes on sensitivity and specificity of Edinburgh Claudication Questionnaire (ECQ) in estimation of Ankle Brachial Index (ABI) detecting lower extremity arterial disease (LEAD). METHODS: Eligible respondents aged fifty years or older underwent first a self-administered (SA-) ECQ, and then an interviewer-administered (IA-) ECQ. Interviewing included additional guidance on symptoms relevant to claudication...
February 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28219334/assessing-the-predictive-power-of-psychological-empowerment-and-health-literacy-for-older-patients-participation-in-health-care-a-cross-sectional-population-based-study
#16
Gabriele Sak, Fabia Rothenfluh, Peter J Schulz
BACKGROUND: Research has confirmed a positive link between patient involvement in decision-making and improvements in health outcomes. The objective of this study was to examine the roles of psychological empowerment and health literacy on the elderly's willingness to engage in treatment decisions. METHODS: A self-administered questionnaire was completed by a randomly selected sample of Swiss adults aged 65-80 years old (N = 826). Multivariate logistic regression was applied to determine the contribution of health literacy, psychological empowerment, and trust in physician on participants' preference to be active, collaborative or passive in decision-making...
February 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28219149/-study-on-vitamin-a-nutritional-status-of-chinese-urban-elderly-residents-in-2010-2012
#17
J Chen, Y C Hu, C Yang, C F Yun, R Wang, D Q Mao, W D Li, Y H Yang, X G Yang, L C Yang
Objective: To assess the vitamin A nutritional status of the Chinese urban elderly population by analyzing serum retinol level in 2010-2012. Methods: Data were collected from the Chinese National Nutrition and Health Survey in 2010-2012. Using the multi-stage stratified cluster sampling method, serum samples from elderly residents aged ≥60 years old were obtained from 34 metropolis and 41 middle-sized and small cities. Demographic data were collected using a questionnaire survey. The serum retinol concentration was determined by high-performance liquid chromatography...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28218985/soft-palatal-melanosis-a-simple-predictor-for-neoplasia-in-the-upper-aerodigestive-tract-in-japanese-alcoholic-men
#18
Kenro Hirata, Akira Yokoyama, Rieko Nakamura, Tai Omori, Hirofumi Kawakubo, Takeshi Mizukami, Katsuya Maruyama, Takanori Kanai, Tetsuji Yokoyama
Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and the soft palatal melanosis. We reviewed digitalized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening. Soft palatal melanosis was observed in 381 (21.3%) of the subjects (distinct, 6...
February 20, 2017: Cancer Science
https://www.readbyqxmd.com/read/28218341/influence-of-hip-and-knee-osteoarthritis-on-dynamic-postural-control-parameters-among-older-fallers
#19
Sumaiyah Mat, Chin Teck Ng, Maw Pin Tan
OBJECTIVE: To compare the relationship between postural control and knee and hip osteoarthritis in older adults with and without a history of falls. METHODS: Fallers were those with ≥ 2 falls or 1 injurious fall over 12 months. Non-fallers were volunteers with no falls in the past year. Radiological evidence of osteoarthritis with no reported symptoms was considered "asymptomatic osteoarthritis", while "symptomatic osteoarthritis" was defined as radiographic osteoarthritis with pain or stiffness...
February 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28216585/effect-of-indoor-temperature-on-physical-performance-in-older-adults-during-days-with-normal-temperature-and-heat-waves
#20
Ulrich Lindemann, Anja Stotz, Nina Beyer, Juha Oksa, Dawn A Skelton, Clemens Becker, Kilian Rapp, Jochen Klenk
Indoor temperature is relevant with regard to mortality and heat-related self-perceived health problems. The aim of this study was to describe the association between indoor temperature and physical performance in older adults. Eighty-one older adults (84% women, mean age 80.9 years, standard deviation 6.53) were visited every four weeks from May to October 2015 and additionally during two heat waves in July and August 2015. Indoor temperature, habitual gait speed, chair-rise performance and balance were assessed...
February 14, 2017: International Journal of Environmental Research and Public Health
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