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Age 80 and older

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https://www.readbyqxmd.com/read/28731266/a-randomized-double-blind-placebo-controlled-crossover-study-of-the-effects-of-levetiracetam-on-cognition-mood-and-balance-in-healthy-older-adults
#1
Mike R Schoenberg, Ruba S Rum, Katie E Osborn, Mary Ann Werz
OBJECTIVE: The cognitive and mood effects of levetiracetam (LEV) in older adults are not known. This study compared the cognitive and mood effects of LEV to placebo in healthy older adults. METHODS: Cognitive, mood, and balance variables were compared between LEV and placebo using a randomized, double-blind, placebo-controlled crossover study with two 5-week treatment periods. Healthy volunteers (n = 20) aged 65-80 (mean age 72.4) received either LEV or placebo in which the LEV target dose was 1,000 mg/day...
July 21, 2017: Epilepsia
https://www.readbyqxmd.com/read/28728775/mexican-adolescents-self-reports-of-parental-monitoring-and-sexual-communication-for-prevention-of-sexual-risk-behavior
#2
Sandra Paloma Esparza Dávila, Jane Dimmitt Champion, Maria Guadalupe Moreno Monsiváis, Marlene Tovar, Maria Luisa Flores Arias
PURPOSE: Assess perceptions of parental monitoring and sexual communication for sexual health promotion among adolescents who are Mexican. DESIGN AND METHODS: Adolescents (N=153, n=85 females, n=68 males) between 14years (n=80) and 15 years (n=73) were recruited at a public high school in Monterrey in the state of Nuevo Leon, Mexico. All participants were living with a parent(s). Descriptive statistical analyses were conducted to assess sociodemographic characteristics of the group...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28728460/acute-effects-of-moderate-alcohol-consumption-on-postural-stability-in-older-adults
#3
Helen Z Wu, Lisa C Barry, Yinghui Duan, Richard W Bohannon, Jonathan M Covault, James J Grady
This study involved healthy community-living older adults in an investigation of the association between moderate alcohol consumption (AC) and acute changes in postural stability and whether the association differed according to pre-AC balance skills. Thirty-nine moderate drinkers aged ≥ 65 years (62% women; mean age: 73.9 ± 6.1 years) consumed a moderate dose of alcohol (0.4 g/kg; administered as two drinks). Breath alcohol concentration and postural stability were measured at five time points (pre-AC and 40, 80, 120, and 160 minutes post-AC)...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28728345/safety-of-percutaneous-endoscopic-gastrostomy-tubes-in-centenarian-patients
#4
Zain A Sobani, Kevin Tin, Steven Guttmann, Anna A Abbasi, Ira Mayer, Yuriy Tsirlin
Background/Aims: Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, no study has evaluated the safety of PEG tube placement in patients over the age of 100 years. Methods: We conducted a retrospective review of patient records for patients who underwent PEG tube placement. Thirty patients aged 100 years and older were identified and a random sample of 275 patients was selected for comparison. Results: The mean age of the patients was 80...
July 21, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28727937/preoperative-short-form-health-survey-score-is-predictive-of-return-to-play-and-minimal-clinically-important-difference-at-a-minimum-2-year-follow-up-after-anterior-cruciate-ligament-reconstruction
#5
Benedict U Nwachukwu, Brenda Chang, Pramod B Voleti, Patricia Berkanish, Matthew R Cohn, David W Altchek, Answorth A Allen, Riley J Williams
BACKGROUND: There is increased interest in understanding the preoperative determinants of postoperative outcomes. Return to play (RTP) and the patient-reported minimal clinically important difference (MCID) are useful measures of postoperative outcomes after anterior cruciate ligament reconstruction (ACLR). PURPOSE: To define the MCID after ACLR and to investigate the role of preoperative outcome scores for predicting the MCID and RTP after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28727253/systemic-treatment-for-sarcoidosis-was-needed-for-16-of-1810-caucasian-patients
#6
Magdalena M Martusewicz-Boros, Piotr W Boros, Elżbieta Wiatr, Justyna Fijołek, Kazimierz Roszkowski-Śliż
INTRODUCTION AND OBJECTIVE: Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs, although granulomas can also involve all other organs. Fortunately, it is often a self-limiting disease and aggressive treatment is not indicated in majority of cases. However, treatment is recommended when critical organs are affected or the disease is progressive. So far, there is lack of reliable information regarding the frequency of treatment in Caucasian population or data are discordant...
July 20, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28724530/the-population-health-benefits-of-a-healthy-lifestyle-life-expectancy-increased-and-onset-of-disability-delayed
#7
Neil Mehta, Mikko Myrskylä
A key determinant of population health is the behavioral profile of a population. Nearly 80 percent of Americans reach their fifties having smoked cigarettes, been obese, or both. It is unknown to what extent risky behaviors (for example, smoking, having a poor diet, being physically inactive, and consuming an excessive amount of alcohol) collectively are reducing the health and life expectancy of the US population, or what improvements might be achievable in their absence. Using data from the Health and Retirement Study, we studied people ages fifty and older who had never smoked, who were not obese, and who consumed alcohol moderately...
July 19, 2017: Health Affairs
https://www.readbyqxmd.com/read/28723333/enhanced-prophylaxis-plus-antiretroviral-therapy-for-advanced-hiv-infection-in-africa
#8
James Hakim, Victor Musiime, Alex J Szubert, Jane Mallewa, Abraham Siika, Clara Agutu, Simon Walker, Sarah L Pett, Mutsa Bwakura-Dangarembizi, Abbas Lugemwa, Symon Kaunda, Mercy Karoney, Godfrey Musoro, Sheila Kabahenda, Kusum Nathoo, Kathryn Maitland, Anna Griffiths, Margaret J Thomason, Cissy Kityo, Peter Mugyenyi, Andrew J Prendergast, A Sarah Walker, Diana M Gibb
BACKGROUND: In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%. METHODS: In this factorial open-label trial conducted in Uganda, Zimbabwe, Malawi, and Kenya, we enrolled HIV-infected adults and children 5 years of age or older who had not received previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter...
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28721429/frailty-and-fear-of-falling-the-fistac-study
#9
M Esbrí-Víctor, I Huedo-Rodenas, M López-Utiel, J L Navarro-López, M Martínez-Reig, J A Serra-Rexach, L Romero-Rizos, P Abizanda
OBJECTIVE: To analyze the association between frailty and Fear of Falling (FoF) in a cohort of older adults with previous falls. DESIGN: Cross-sectional study (FISTAC). SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete (Spain). PARTICIPANTS: 183 adults older than 69 years, from the Falls Unit, with a history of a previous fall in the last year. MEASUREMENTS: FoF was assessed at baseline using the Falls Efficacy Scale International (FES-I) and three questions previously validated...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28720169/characteristics-of-healthy-older-adults-that-influence-self-rated-cognitive-function
#10
Bryce P Mulligan, Colette M Smart, Sidney J Segalowitz, Stuart W S MacDonald
OBJECTIVES: We sought to clarify the nature of self-reported cognitive function among healthy older adults by considering the short-term, within-person association (coupling) of subjective cognitive function with objective cognitive performance. We expected this within-person coupling to differ between persons as a function of self-perceived global cognitive decline and depression, anxiety, or neuroticism. METHODS: This was an intensive measurement (short-term longitudinal) study of 29 older adult volunteers between the ages of 65 and 80 years without an existing diagnosis of dementia or mild cognitive impairment...
July 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28717854/pharmaceutically-treated-anxiety-but-not-depression-prior-to-cancer-diagnosis-predicts-the-onset-of-cardiovascular-disease-among-breast-cancer-survivors
#11
Dounya Schoormans, Lonneke van de Poll-Franse, Pauline Vissers, Myrthe P P van Herk-Sukel, Susanne S Pedersen, Nina Rottmann, Trine Horsbøl, Susanne Dalton, Johan Denollet
PURPOSE: To examine the associations between pharmaceutically treated anxiety and depression present in the year prior to breast cancer diagnosis and the risk of incident cardiovascular disease (CVD), while controlling for traditional cardiovascular risk factors and clinical characteristics in a population-based observational study. METHODS: Adult 1-year breast cancer survivors (n = 7227), diagnosed between 01-01-1999 and 12-31-2010, with no history of CVD, were selected from the Netherlands Cancer Registry...
July 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28716973/incremental-benefit-of-cardiac-resynchronisation-therapy-with-versus-without-a-defibrillator
#12
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Dieter Nuyens, Hugo Van Herendael, Maximo Rivero-Ayerza, Wilson H Tang, Wilfried Mullens
OBJECTIVE: To determine the incremental value of implantable cardioverter defibrillators (ICD) in contemporary optimally treated patients with heart failure (HF) undergoing cardiac resynchronisation therapy (CRT). METHODS: Consecutive patients with HF undergoing CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) implantation in a single tertiary care centre between October 2008 and August 2015 were retrospectively evaluated. For patients with a primary prevention indication of the CRT-D, no benefit of the ICD was defined as absence of appropriate therapy (device analysis) or lethal ventricular tachyarrhythmias (mode of death analysis) during follow-up...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28715624/-chickenpox-seroprevalence-among-healthcare-and-social-assistance-workers-in-catalonia-spain
#13
Joan Inglés Torruella, Rosa Gil Soto
AIMS: Chickenpox is a frequent and contagious disease in healthcare and social assistance settings, and there are limited data on seroprevalence among workers in this sector. We estimated susceptibility to chickenpox among workers, by demographic and occupational variables, and measured the rate of seroprotection after vaccination. METHODS: A retrospective seroprevalence study of chickenpox (varicella) and serological vaccine response. The earliest recorded varicella serology, analyzed by the ELISA method, was identified for each worker from a health surveillance database of a group of medical and healthcare companies in Catalonia, recorded between 2004 and 2013...
July 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28715306/a-data-rich-longitudinal-wellness-study-for-the-digital-age-fixing-a-broken-medical-system-requires-data-about-each-patient
#14
Gustavo Glusman
We live in an age of plentiful information, collected continuously by pervasive gadgetry, distributed through digital and social networks, and mined deeply by ever-more-powerful analytics systems. And yet, one of the things we know the least about is our bodies. When it comes to our own health, we are driving blindly. Modern medicine has clearly been remarkably successful, as evidenced by continually growing life expectancies. For example, the number of people 65 and older in the United States has seen a steady increase over the last century, rising from 3...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28713184/childhood-iq-and-survival-to-79-follow-up-of-94-of-the-scottish-mental-survey-1947
#15
Iva Čukić, Caroline E Brett, Catherine M Calvin, G David Batty, Ian J Deary
OBJECTIVE: To extend previous literature that suggests higher IQ in youth is associated with living longer. Previous studies have been unable to assess reliably whether the effect differs across sexes and ages of death, and whether the effect is graded across different levels of IQ. METHODS: We test IQ-survival associations in 94% of the near-entire population born in Scotland in 1936 who took an IQ test at age 11 (n = 70,805) and were traced in a 68-year follow-up...
July 2017: Intelligence
https://www.readbyqxmd.com/read/28712941/rituximab-biosimilar-and-reference-rituximab-in-patients-with-previously-untreated-advanced-follicular-lymphoma-assist-fl-primary-results-from-a-confirmatory-phase-3-double-blind-randomised-controlled-study
#16
Wojciech Jurczak, Ilídia Moreira, Govind Babu Kanakasetty, Eduardo Munhoz, Maria Asunción Echeveste, Pratyush Giri, Nelson Castro, Juliana Pereira, Luiza Akria, Sergey Alexeev, Eugeniy Osmanov, Peijuan Zhu, Siyka Alexandrova, Angela Zubel, Olof Harlin, Jutta Amersdorffer
BACKGROUND: GP2013 is a rituximab biosimilar developed to stringent development guidelines, including non-clinical and preclinical investigations and clinical trials in rheumatoid arthritis and follicular lymphoma. We aimed to compare the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of GP2013 plus cyclophosphamide, vincristine, and prednisone (GP2013-CVP) with rituximab-CVP (R-CVP) in patients with follicular lymphoma. METHODS: In this phase 3, multinational, double-blind, randomised, controlled trial, adults (aged 18 years or older) with previously untreated, advanced stage (Ann Arbor stage III or IV) follicular lymphoma of WHO histological grades 1, 2, or 3a were randomly assigned (1:1) using interactive response technology to eight cycles of GP2013-CVP or R-CVP (combination phase), followed by monotherapy maintenance in responders for a 2-year period...
July 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28712940/efficacy-pharmacokinetics-and-safety-of-the-biosimilar-ct-p10-compared-with-rituximab-in-patients-with-previously-untreated-advanced-stage-follicular-lymphoma-a-randomised-double-blind-parallel-group-non-inferiority-phase-3-trial
#17
Won Seog Kim, Christian Buske, Michinori Ogura, Wojciech Jurczak, Juan-Manuel Sancho, Edvard Zhavrid, Jin Seok Kim, José-Ángel Hernández-Rivas, Aliaksandr Prokharau, Mariana Vasilica, Rajinish Nagarkar, Dzhelil Osmanov, Larry W Kwak, Sang Joon Lee, Sung Young Lee, Yun Ju Bae, Bertrand Coiffier
BACKGROUND: Studies in patients with rheumatoid arthritis have shown that the rituximab biosimilar CT-P10 (Celltrion, Incheon, South Korea) has equivalent efficacy and pharmacokinetics to rituximab. In this phase 3 study, we aimed to assess the non-inferior efficacy and pharmacokinetic equivalence of CT-P10 compared with rituximab, when used in combination with cyclophosphamide, vincristine, and prednisone (CVP) in patients with newly diagnosed advanced-stage follicular lymphoma. METHODS: In this ongoing, randomised, double-blind, parallel-group, active-controlled study, patients aged 18 years or older with Ann Arbor stage III-IV follicular lymphoma were assigned 1:1 to CVP plus intravenous infusions of 375 mg/m(2) CT-P10 or rituximab on day 1 of eight 21-day cycles...
July 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28712657/prevalence-of-age-related-macular-degeneration-in-europe-the-past-and-the-future
#18
Johanna M Colijn, Gabriëlle H S Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L Cachulo, Anthony P Khawaja, Audrey Cougnard-Gregoire, Bénédicte M J Merle, Christina Korb, Maja G Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T V M de Jong, Johannes R Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertelsen, Norbert Pfeiffer, Astrid E Fletcher, Paul J Foster, Rufino Silva, Jean-François Korobelnik, Cécile Delcourt, Caroline C W Klaver
PURPOSE: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. DESIGN: Meta-analysis of prevalence data. PARTICIPANTS: A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe...
July 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28712639/reduction-in-fracture-resistance-of-the-root-with%C3%A2-aging
#19
Weishi Yan, Carolina Montoya, Marit Øilo, Alex Ossa, Avina Paranjpe, Hai Zhang, Dwayne Arola
INTRODUCTION: The incidence of vertical root fracture in endodontically treated teeth increases with patient age. This study evaluated the microstructure, chemical composition, and mechanical properties of radicular dentin as a function of aging. METHODS: Single-rooted teeth were obtained from adult donors ranging from age 15 to older than 80 years. Beams were extracted from the middle third of the root and subjected to 4-point flexure to failure to evaluate strength of dentin in terms of donor age...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28712429/the-association-between-multiple-chemical-sensitivity-and-mental-illness-evidence-from-a-nationally-representative-sample-of-canadians
#20
Dylan Johnson, Ian Colman
OBJECTIVE: The goal of the present study was to investigate the association between multiple chemical sensitivity (MCS) and major depressive disorder (MDD), generalized anxiety disorder (GAD), MDD and GAD comorbidity (MDD+GAD), severe distress, and positive mental wellbeing. METHODS: This cross-sectional investigation was carried out using the 2012 Canadian Community Health Survey - Mental Health Component. The study population consisted of 21,977 individuals aged 20 and older, from Canada's ten provinces...
August 2017: Journal of Psychosomatic Research
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