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Fountain of youth

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https://www.readbyqxmd.com/read/28041781/the-fountain-of-youth-by-targeting-senescent-cells
#1
REVIEW
Peter L J de Keizer
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner...
December 20, 2016: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28041565/the-fountain-of-youth-by-targeting-senescent-cells
#2
REVIEW
Peter L J de Keizer
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner...
January 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/27924789/kallikrein-kinin-system-is-it-the-fountain-of-youth
#3
Giulio Garaffa, Fabio Castiglione
No abstract text is available yet for this article.
January 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27599462/metschnikowia-half-tetrads-a-regicide-and-the-fountain-of-youth
#4
Marc-André Lachance
The purpose of this review is to introduce Metschnikowia to the yeast researcher community and to convince readers that the genus is a worthwhile object of study in developmental biology, genetics, ecology and biotechnology. Metschnikowia sits at the foundation of modern immunology, having been instrumental in the discovery of animal phagocytosis. Some 81 species form a monophyletic group within the Metschnikowiaceae, which also include the smaller genus Clavispora and a few clades of Candida species. The family stands out by the habit of forming, by meiosis, only two ascospores, which in Metschnikowia are needle shaped...
September 7, 2016: Yeast
https://www.readbyqxmd.com/read/27588026/better-living-through-chemistry-caloric-restriction-cr-and-cr-mimetics-alter-genome-function-to-promote-increased-health-and-lifespan
#5
REVIEW
Zoe E Gillespie, Joshua Pickering, Christopher H Eskiw
Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans. Many drugs and other compounds naturally occurring in our diet (nutraceuticals) have been postulated to act as mimetics of caloric restriction, leading to a wave of research investigating the efficacy of these compounds in preventing age-related diseases and promoting healthier, longer lifespans. Although well studied at the biochemical level, there are still many unanswered questions about how CR and CR mimetics impact genome function and structure...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27580804/searching-for-the-%C3%AE-cell-fountain-of-youth
#6
Nathalie Jouvet, Jennifer L Estall
Aging affects every species and tissue but not in equal ways. Human pancreatic β-cells lose their ability to replicate, regenerate, and secrete insulin as one gets older. This natural process increases risk of developing diabetes as you age and is a concern for donor islets and stem cells obtained from older subjects destined for transplantation or emerging regenerative therapies. Using fluidic sorting and RNA sequencing on single cells, Xin et al describe a transcriptional signature of mouse β-cell aging between adulthood and a very old age...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27474426/power-process-and-protection-juveniles-as-defendants-in-the-justice-system
#7
Jennifer L Woolard, Kristin Henning, Erika Fountain
The juvenile court was created in 1899 in part to remedy the unfairness of trying youth in the adult criminal justice system, but its success at rectifying those problems is unclear. One concern is that the vast majority of youth who are adjudicated delinquent are adjudicated after waiving their right to trial and entering a guilty plea. Fairness and equity in the plea bargaining process are premised on the assumption that youth have the capacity to understand and elect between available options and will be given a meaningful opportunity to choose without coercion and deception...
2016: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/27406358/testosterone-treatment-in-older-men
#8
LETTER
Michaël R Laurent, Leen Antonio, Dirk Vanderschueren
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406357/testosterone-treatment-in-older-men
#9
LETTER
Douglas A Mata, Ranjith Ramasamy, Larry I Lipshultz
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406356/testosterone-treatment-in-older-men
#10
LETTER
Konstantinos Stavropoulos, Chrysoula Boutari, Konstantinos Imprialos
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406355/testosterone-treatment-in-older-men
#11
LETTER
Thomas T Perls
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406354/testosterone-treatment-in-older-men
#12
LETTER
Peter J Snyder, Susan S Ellenberg, John T Farrar
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27072490/cardiac-aging-and-the-fountain-of-youth
#13
EDITORIAL
Barry A Borlaug
No abstract text is available yet for this article.
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26827953/1-25-dihydroxyvitamin-d-and-klotho-a-tale-of-two-renal-hormones-coming-of-age
#14
Mark R Haussler, G Kerr Whitfield, Carol A Haussler, Marya S Sabir, Zainab Khan, Ruby Sandoval, Peter W Jurutka
1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes encoding factors stimulating calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling exerts feedback control of Ca/PO4 via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, fibrosis, and associated pathologies...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/26229129/commentary-on-the-fountain-of-stem-cell-based-youth-online-portrayals-of-anti-aging-stem-cell-technologies
#15
COMMENT
Afshin Mosahebi
No abstract text is available yet for this article.
August 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/26227874/enhanced-enos-activation-as-the-fountain-of-youth-for-vascular-disease-is-bpifb4-what-ponce-de-le%C3%A3-n-was-looking-for
#16
EDITORIAL
Jan R Kraehling, William C Sessa
No abstract text is available yet for this article.
July 31, 2015: Circulation Research
https://www.readbyqxmd.com/read/26041720/fountain-of-youth-in-the-aorta
#17
EDITORIAL
Hiroki Aoki
No abstract text is available yet for this article.
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26003784/gdf11-and-the-mythical-fountain-of-youth
#18
COMMENT
Caroline E Brun, Michael A Rudnicki
Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.
July 7, 2015: Cell Metabolism
https://www.readbyqxmd.com/read/25922365/the-fountain-of-stem-cell-based-youth-online-portrayals-of-anti-aging-stem-cell-technologies
#19
Christen M Rachul, Ivona Percec, Timothy Caulfield
BACKGROUND: The hype surrounding stem cell science has created a market opportunity for the cosmetic industry. Cosmetic and anti-aging products and treatments that make claims regarding stem cell technology are increasingly popular, despite a lack of evidence for safety and efficacy of such products. OBJECTIVES: This study explores how stem cell-based products and services are portrayed to the public through online sources, in order to gain insight into the key messages available to consumers...
August 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/25917148/acute-coronary-syndromes-acute-mi-in-women-the-fountain-of-youth-has-run-dry
#20
COMMENT
Cindy L Grines
No abstract text is available yet for this article.
June 2015: Nature Reviews. Cardiology
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