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Fountain of youth

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https://www.readbyqxmd.com/read/29729760/editorial-commentary-platelet-rich-plasma-fountain-of-youth-cart-before-the-horse-or-both
#1
EDITORIAL
Matthew J Salzler
Platelet-rich plasma (PRP) injections have gained widespread popularity for the treatment of many orthopaedic conditions including osteoarthritis of the knee. Despite its increasing usage, there is comparatively little evidence regarding the mechanisms of action and relative roles of the multiple growth factors contained within PRP. That said, although future research will clarify the issue, current evidence suggests that PRP is safe and, for the treatment of knee osteoarthritis, effective.
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29651863/incarnation-and-the-dynamics-of-medical-promises-dhea-as-a-fountain-of-youth-hormone
#2
Boris Hauray, Sébastien Dalgalarrondo
For more than a decade, the sociology of hope and expectations has gained growing influence in the social studies of health, medicine, and healthcare. This literature has stressed the role of representations of the future-through images, metaphors, theories, or visions-in the medical sector and analyzed the translation of these discursive contents into social practices and organizations. This article builds on these results and intends to explore a dimension that has received less attention: the incarnation of medical promises...
April 1, 2018: Health (London)
https://www.readbyqxmd.com/read/29593463/young-blood-rejuvenates-old-bodies-a-call-for-reflection-when-moving-from-mice-to-men
#3
Bjørn Hofmann
Connecting the circulatory system of old and young mice (parabiosis) is documented to have rejuvenating effects on cells, tissues, organs, and functions. A wide range of benefits are envisioned. Blood-based rejuvenation can come to totally change population health and aging. The first blood rejuvenation studies on humans with Alzheimer's disease have started. It puts blood at the center of therapy and revitalizes the historical line of humoral pathology from Hippocrates and Harvey, creating a new type of 'bloodletting...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29579297/bringing-water-to-the-fountain-of-youth-how-new-evidence-of-sex-reversals-helps-show-how-sex-chromosomes-are-maintained-over-evolutionary-time
#4
Joseph Caspermeyer
No abstract text is available yet for this article.
April 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29531798/fountain-of-youth-of-pancreatic-cancer-cells-the-extracellular-matrix
#5
Victoire Gouirand, Sophie Vasseur
No abstract text is available yet for this article.
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29394416/sex-chromosome-recombination-in-common-frogs-brings-water-to-the-fountain-of-youth
#6
Nicolas Rodrigues, Tania Studer, Christophe Dufresnes, Nicolas Perrin
According to the canonical model of sex-chromosome evolution, the degeneration of Y or W chromosomes (as observed in mammals and birds, respectively) results from an arrest of recombination in the heterogametic sex, driven by the fixation of sexually antagonistic mutations. However, sex chromosomes have remained homomorphic in many lineages of fishes, amphibians, and nonavian reptiles. According to the "fountain-of-youth" model, this homomorphy results from occasional events of sex reversal. If recombination arrest in males is controlled by maleness per se (and not by genotype), then Y chromosomes are expected to recombine in XY females, preventing their long-term degeneration...
April 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29106993/the-role-of-cellular-senescence-in-aging-through-the-prism-of-koch-like-criteria
#7
REVIEW
Hagai Yanai, Vadim E Fraifeld
Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the field has been accumulated and intensively discussed. Here, we attempted to organize the evidence "for" and "against" the hypothesized causal role of CS in aging. For that purpose, we utilized robust Koch-like logical criteria, based on the assumption that some quantitative relationships between the accumulation of senescent cells and aging rate should exist. If so, it could be expected that (i) the "CS load" would be greater in the premature aging phenotype and lesser in longevity phenotype; (ii) CS would promote age-related diseases, and (iii) the interventions that modulate the levels of senescent cells should also modulate health/lifespan...
January 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29104943/the-fountain-of-youth-a-tale-of-parabiosis-stem-cells-and-rejuvenation
#8
Massimo Conese, Annalucia Carbone, Elisa Beccia, Antonella Angiolillo
Transfusion (or drinking) of blood or of its components has been thought as a rejuvenation method since ancient times. Parabiosis, the procedure of joining two animals so that they share each others blood circulation, has revitalized the concept of blood as a putative drug. Since 2005, a number of papers have reported the anti-ageing effect of heterochronic parabiosis, which is joining an aged mouse to a young partner. The hallmark of aging is the decline of regenerative properties in most tissues, partially attributed to impaired function of stem and progenitor cells...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28802278/gdf11-a-fountain-of-youth-for-the-ageing-copd-lung
#9
EDITORIAL
Ma'en Obeidat, Don D Sin
No abstract text is available yet for this article.
October 2017: Thorax
https://www.readbyqxmd.com/read/28797374/hormone-replacement-the-fountain-of-youth
#10
REVIEW
Bradley R Williams, Janet Soojeung Cho
Natural aging brings reduced production of growth and sex hormones, beginning in middle age, with noticeable physiologic changes by the sixth or seventh decade of life: reduced muscle mass, energy, and exercise capacity and alterations in sexual function. Hormones and hormone precursors have been investigated to delay changes in body composition, strength, and physical and cognitive function. Menopausal hormone therapy is effective for vasomotor and genitourinary symptoms. Testosterone is effective in men with hypogonadism and declines in physiologic function...
September 2017: Primary Care
https://www.readbyqxmd.com/read/28691755/maybe-the-fountain-of-youth-was-actually-a-treadmill-role-of-exercise-in-reversing-microvascular-and-diastolic-dysfunction
#11
Jacob P DeBlois, Wesley K Lefferts
No abstract text is available yet for this article.
September 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28611710/promising-links-between-meditation-and-reduced-brain-aging-an-attempt-to-bridge-some-gaps-between-the-alleged-fountain-of-youth-and-the-youth-of-the-field
#12
REVIEW
Florian Kurth, Nicolas Cherbuin, Eileen Luders
Over the last decade, an increasing number of studies has reported a positive impact of meditation on cerebral aging. However, the underlying mechanisms for these seemingly brain-protecting effects are not well-understood. This may be due to the fact, at least partly, that systematic empirical meditation research has emerged only recently as a field of scientific scrutiny. Thus, on the one hand, critical questions remain largely unanswered; and on the other hand, outcomes of existing research require better integration to build a more comprehensive and holistic picture...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28531560/uneasy-encounters-youth-social-dis-comfort-and-the-autistic-self
#13
Edmund Coleman-Fountain
Notions of deficit and 'faultiness' shape depictions of the association between autism and uneasy social relationships. That framing has been the focus of critique by autistic activists and scholars who, exploring autistic people's sociality, reframe issues of social difficulty in terms of inequality and discomfort. Located within this set of debates, the article analyses data from a UK based study of mental health narratives derived from semi-structured interviews with 19 autistic young adults aged 23 to 24...
July 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28475881/eyeing-the-fountain-of-youth
#14
COMMENT
Magali Saint-Geniez, Mariana Aparecida B Rosales
Stem cell-based disease modeling is an emerging technology for the mechanistic study and therapeutic screening of complex ocular pathologies. In this issue of Cell Stem Cell, Saini et al. (2017) show that iPSC-derived RPE cells from age-related macular degeneration patients express increased levels of pro-inflammatory factors that can be normalized by the anti-aging drug nicotinamide.
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28456364/saphenous-vein-graft-patency-and-fountain-of-youth
#15
EDITORIAL
Paul Kurlansky
No abstract text is available yet for this article.
August 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28426866/cognitive-fountain-of-youth
#16
Reid Hoshide, Rahul Jandial
No abstract text is available yet for this article.
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28364326/of-cytometry-stem-cells-and-fountain-of-youth
#17
REVIEW
Dariusz Galkowski, Mariusz Z Ratajczak, Janusz Kocki, Zbigniew Darzynkiewicz
Outlined are advances of cytometry applications to identify and sort stem cells, of laser scanning cytometry and ImageStream imaging instrumentation to further analyze morphometry of these cells, and of mass cytometry to classify a multitude of cellular markers in large cell populations. Reviewed are different types of stem cells, including potential candidates for cancer stem cells, with respect to their "stemness", and other characteristics. Appraised is further progress in identification and isolation of the "very small embryonic-like stem cells" (VSELs) and their autogenous transplantation for tissue repair and geroprotection...
August 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28314502/nutrient-sensing-and-the-oxidative-stress-response
#18
REVIEW
Hanzhi Luo, Hou-Hsien Chiang, Makensie Louw, Albert Susanto, Danica Chen
The simplicity and effectiveness of calorie restriction (CR) in lifespan and healthspan extension have fascinated generations searching for the Fountain of Youth. CR reduces levels of oxidative stress and damage, which have been postulated in the free radical theory of aging as a major cause of aging and diseases of aging. This reduction has long been viewed as a result of passive slowing of metabolism. Recent advances in nutrient sensing have provided molecular insights into the oxidative stress response and suggest that CR triggers an active defense program involving a cascade of molecular regulators to reduce oxidative stress...
June 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28041781/the-fountain-of-youth-by-targeting-senescent-cells
#19
REVIEW
Peter L J de Keizer
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner...
December 20, 2016: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28041565/the-fountain-of-youth-by-targeting-senescent-cells
#20
REVIEW
Peter L J de Keizer
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner...
January 2017: Trends in Molecular Medicine
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