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Fountain of youth

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https://www.readbyqxmd.com/read/27599462/metschnikowia-half-tetrads-a-regicide-and-the-fountain-of-youth
#1
Marc-André Lachance
The purpose of this review is to introduce Metschnikowia to the yeast researcher community and to convince readers that the genus is a worthwhile object of study in developmental biology, genetics, ecology and biotechnology. Metschnikowia sits at the foundation of modern immunology, having been instrumental in the discovery of animal phagocytosis. Some 81 species form a monophyletic group within the Metschnikowiaceae, which also include the smaller genus Clavispora and a few clades of Candida species. The family stands out by the habit of forming, by meiosis, only two ascospores, which in Metschnikowia are needle shaped...
September 7, 2016: Yeast
https://www.readbyqxmd.com/read/27588026/better-living-through-chemistry-caloric-restriction-cr-and-cr-mimetics-alter-genome-function-to-promote-increased-health-and-lifespan
#2
REVIEW
Zoe E Gillespie, Joshua Pickering, Christopher H Eskiw
Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans. Many drugs and other compounds naturally occurring in our diet (nutraceuticals) have been postulated to act as mimetics of caloric restriction, leading to a wave of research investigating the efficacy of these compounds in preventing age-related diseases and promoting healthier, longer lifespans. Although well studied at the biochemical level, there are still many unanswered questions about how CR and CR mimetics impact genome function and structure...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27580804/searching-for-the-%C3%AE-cell-fountain-of-youth
#3
Nathalie Jouvet, Jennifer L Estall
Aging affects every species and tissue but not in equal ways. Human pancreatic β-cells lose their ability to replicate, regenerate, and secrete insulin as one gets older. This natural process increases risk of developing diabetes as you age and is a concern for donor islets and stem cells obtained from older subjects destined for transplantation or emerging regenerative therapies. Using fluidic sorting and RNA sequencing on single cells, Xin et al describe a transcriptional signature of mouse β-cell aging between adulthood and a very old age...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27474426/power-process-and-protection-juveniles-as-defendants-in-the-justice-system
#4
Jennifer L Woolard, Kristin Henning, Erika Fountain
The juvenile court was created in 1899 in part to remedy the unfairness of trying youth in the adult criminal justice system, but its success at rectifying those problems is unclear. One concern is that the vast majority of youth who are adjudicated delinquent are adjudicated after waiving their right to trial and entering a guilty plea. Fairness and equity in the plea bargaining process are premised on the assumption that youth have the capacity to understand and elect between available options and will be given a meaningful opportunity to choose without coercion and deception...
2016: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/27406358/testosterone-treatment-in-older-men
#5
LETTER
Michaël R Laurent, Leen Antonio, Dirk Vanderschueren
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406357/testosterone-treatment-in-older-men
#6
LETTER
Douglas A Mata, Ranjith Ramasamy, Larry I Lipshultz
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406356/testosterone-treatment-in-older-men
#7
LETTER
Konstantinos Stavropoulos, Chrysoula Boutari, Konstantinos Imprialos
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406355/testosterone-treatment-in-older-men
#8
LETTER
Thomas T Perls
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27406354/testosterone-treatment-in-older-men
#9
LETTER
Peter J Snyder, Susan S Ellenberg, John T Farrar
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27072490/cardiac-aging-and-the-fountain-of-youth
#10
EDITORIAL
Barry A Borlaug
No abstract text is available yet for this article.
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26827953/1-25-dihydroxyvitamin-d-and-klotho-a-tale-of-two-renal-hormones-coming-of-age
#11
Mark R Haussler, G Kerr Whitfield, Carol A Haussler, Marya S Sabir, Zainab Khan, Ruby Sandoval, Peter W Jurutka
1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes encoding factors stimulating calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling exerts feedback control of Ca/PO4 via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, fibrosis, and associated pathologies...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/26229129/commentary-on-the-fountain-of-stem-cell-based-youth-online-portrayals-of-anti-aging-stem-cell-technologies
#12
COMMENT
Afshin Mosahebi
No abstract text is available yet for this article.
August 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/26227874/enhanced-enos-activation-as-the-fountain-of-youth-for-vascular-disease-is-bpifb4-what-ponce-de-le%C3%A3-n-was-looking-for
#13
EDITORIAL
Jan R Kraehling, William C Sessa
No abstract text is available yet for this article.
July 31, 2015: Circulation Research
https://www.readbyqxmd.com/read/26041720/fountain-of-youth-in-the-aorta
#14
EDITORIAL
Hiroki Aoki
No abstract text is available yet for this article.
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26003784/gdf11-and-the-mythical-fountain-of-youth
#15
COMMENT
Caroline E Brun, Michael A Rudnicki
Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.
July 7, 2015: Cell Metabolism
https://www.readbyqxmd.com/read/25922365/the-fountain-of-stem-cell-based-youth-online-portrayals-of-anti-aging-stem-cell-technologies
#16
Christen M Rachul, Ivona Percec, Timothy Caulfield
BACKGROUND: The hype surrounding stem cell science has created a market opportunity for the cosmetic industry. Cosmetic and anti-aging products and treatments that make claims regarding stem cell technology are increasingly popular, despite a lack of evidence for safety and efficacy of such products. OBJECTIVES: This study explores how stem cell-based products and services are portrayed to the public through online sources, in order to gain insight into the key messages available to consumers...
August 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/25917148/acute-coronary-syndromes-acute-mi-in-women-the-fountain-of-youth-has-run-dry
#17
COMMENT
Cindy L Grines
No abstract text is available yet for this article.
June 2015: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/25845195/-age-related-dehydroepiandrosterone-decrease-clinical-significance-and-therapeutic-interest
#18
REVIEW
Nikolaos Samaras, Dimitrios Samaras, Alexandre Forster, Emilia Frangos, Jacques Philippe
Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroids in humans, but their levels fall with age. This decrease has been associated with several age related diseases such as falls, osteoporosis, depression, atherosclerosis and sexual disorders. Moreover, studies have shown positive effects of DHEA administration on several of these disorders, with a satisfying safety profile. Unfortunately, DHEA has been too frequently mediatized as a "fountain of youths, which was responsible for either inadequate prescription, or prescription refusal...
January 28, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25760821/rejuvenating-the-senescent-heart
#19
REVIEW
Nathalie Nguyen, Mark A Sussman
PURPOSE OF REVIEW: The purpose of this review is to provide an update on the cardiac stem cell field with an emphasis on aging and to suggest some relevant strategies directed toward rejuvenation of the senescent heart. RECENT FINDINGS: Stem cells were long considered as a fountain of youth and were assumed to be equipped against any form of aging effect. However, it is now clear that stem cells suffer the consequences of aging as well. With the discovery that cardiac stem cells reside in the heart comes the question whether these cells are also impaired upon aging...
May 2015: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/25579854/sirtuin-function-in-aging-heart-and-vessels
#20
REVIEW
Chiara Cencioni, Francesco Spallotta, Antonello Mai, Fabio Martelli, Antonella Farsetti, Andreas M Zeiher, Carlo Gaetano
Age is the most important risk factor for metabolic alterations and cardiovascular accidents. Although class III histone deacetylases, alias Sirtuins, have been appealed as "the fountain of youth" their role in longevity control and prevention of aging-associated disease is still under debate. Indeed, several lines of evidence indicate that sirtuin activity is strictly linked to metabolism and dependent on NAD(+) synthesis both often altered as aging progresses. During aging the cardiovascular system is attacked by a variety of environmental stresses, including those determined by high blood glucose and lipid levels, or by the presence of oxidized lipoproteins which, among others, determine important oxidative stress signals...
June 2015: Journal of Molecular and Cellular Cardiology
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