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https://www.readbyqxmd.com/read/27909828/the-dopamine-related-polymorphisms-bdnf-comt-drd2-drd3-and-drd4-are-not-linked-with-changes-in-csf-dopamine-levels-and-frequency-of-hiv-infection
#1
Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt, J Hain, P Riederer, E Koutsilieri
We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection)...
December 1, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27893846/cerebellum-transcriptome-of-mice-bred-for-high-voluntary-activity-offers-insights-into-locomotor-control-and-reward-dependent-behaviors
#2
Kelsey Caetano-Anollés, Justin S Rhodes, Theodore Garland, Sam D Perez, Alvaro G Hernandez, Bruce R Southey, Sandra L Rodriguez-Zas
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties. Changes in the cerebellum transcriptional networks of mice from a line selectively bred for High voluntary running (H) were profiled relative to an unselected Control (C) line. The environmental modulation of these changes was assessed both in activity environments corresponding to 7 days of Free (F) access to running wheel and to Blocked (B) access on day 7...
2016: PloS One
https://www.readbyqxmd.com/read/27892953/thalamic-mir-338-3p-mediates-auditory-thalamocortical-disruption-and-its-late-onset-in-models-of-22q11-2-microdeletion
#3
Sungkun Chun, Fei Du, Joby J Westmoreland, Seung Baek Han, Yong-Dong Wang, Donnie Eddins, Ildar T Bayazitov, Prakash Devaraju, Jing Yu, Marcia M Mellado Lagarde, Kara Anderson, Stanislav S Zakharenko
Although 22q11.2 deletion syndrome (22q11DS) is associated with early-life behavioral abnormalities, affected individuals are also at high risk for the development of schizophrenia symptoms, including psychosis, later in life. Auditory thalamocortical (TC) projections recently emerged as a neural circuit that is specifically disrupted in mouse models of 22q11DS (hereafter referred to as 22q11DS mice), in which haploinsufficiency of the microRNA (miRNA)-processing-factor-encoding gene Dgcr8 results in the elevation of the dopamine receptor Drd2 in the auditory thalamus, an abnormal sensitivity of thalamocortical projections to antipsychotics, and an abnormal acoustic-startle response...
November 28, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27886638/preliminary-evidence-that-negative-symptom-severity-relates-to-multilocus-genetic-profile-for-dopamine-signaling-capacity-and-d2-receptor-binding-in-healthy-controls-and-in-schizophrenia
#4
Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barch
Deficits in central, subcortical dopamine (DA) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. To investigate these relationships, we assessed negative symptoms with the Schedule for the Assessment of Negative Symptoms and the Brief Negative Symptom Scale (BNSS) and self-reported anhedonia with the Scales for Physical and Social Anhedonia (SPSA), Temporal Experience of Pleasure Scale, and Snaith-Hamilton Pleasure Scale in 36 healthy controls (HC), 27 siblings (SIB) of individuals with schizophrenia, and 66 individuals with schizophrenia or schizoaffective disorder (SCZ)...
November 17, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27883923/gilles-de-la-tourette-syndrome-is-associated-with-hypermethylation-of-the-dopamine-d2-receptor-gene
#5
Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frieling
Several lines of evidence support a "dopaminergic hypothesis" in the pathophysiology of Gilles de la Tourette syndrome (TS). The aim of this study was to investigate for the first time epigenetic changes in DNA methylation in different dopamine genes in adult patients with TS. We included 51 well characterized adult patients with TS (41 males, 10 females, mean age = 35 ± 12.6 years, range, 18-71 years) and compared results with data from a group of 51 sex- and age-matched healthy controls. Bisulfite sequencing was used to measure peripheral DNA methylation of the dopamine transporter (DAT), the dopamine D2 receptor (DRD2), and the catechol-O-methyltransferase (COMT) genes...
November 12, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27878728/structural-organization-of-cerebral-basolateral-nucleus-of-the-amygdaloid-complex-in-wag-rij-rats-with-different-genotypes-by-the-taq-1a-locus-of-dopamine-2-receptor-gene-drd2
#6
A V Akhmadeev, N F Leushkina, L B Kalimullina
Anxiety levels and structural organization of the basolateral nucleus of the amygdaloid complex were analyzed in WAG/Rij rats with genotypes A1/A1 and A2/A2 by DRD2 locus Taq 1A. Association of anxious behavior with A2/A2 genotype and the relationship between the structural organization of the nucleus and polymorphic variants of this locus are detected.
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27871902/the-effects-of-long-term-estradiol-treatment-on-social-behavior-and-gene-expression-in-adult-female-rats
#7
Alexandra N Garcia, Kelsey Bezner, Christina Depena, Weiling Yin, Andrea C Gore
This study tested the effects of long-term estradiol (E2) replacement on social behavior and gene expression in brain nuclei involved in the regulation of these social behaviors in adult female rats. We developed an ultrasonic vocalization (USV) test and a sociability test to examine communications, social interactions, and social preference, using young adult female cagemates. All rats were ovariectomized (OVX) and implanted with a Silastic capsule containing E2 or vehicle, and housed in same-treatment pairs for a 3-month period...
November 18, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27867061/interaction-between-drd2-variation-and-sound-environment-on-mood-and-emotion-related-brain-activity
#8
T Quarto, M C Fasano, P Taurisano, L Fazio, L A Antonucci, B Gelao, R Romano, M Mancini, A Porcelli, R Masellis, K J Pallesen, A Bertolino, G Blasi, E Brattico
Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise...
November 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27852134/further-evidence-of-the-limited-role-of-candidate-genes-in-relation-to-infant-mother-attachment-outcomes
#9
Esther M Leerkes, Lindsey R Gedaly, Nan Zhou, Susan Calkins, Vincent C Henrich, Andrew Smolen
In this paper, we examine the associations between specific candidate genes (DRD2, DRD4, COMT, biallelic and tri-allelic 5HTTLPR, and OXTR) and infant attachment outcomes as main effects and in conjunction with maternal sensitivity. The sample included 200 infants (97 European American, 94 African-American, and 9 biracial) and their mothers. Maternal sensitivity and overtly negative maternal behavior were observed when infants were 6 months and 1 year old in distress-eliciting contexts, attachment was assessed via the Strange Situation at age 1, and DNA samples were collected when children were 2 years old...
November 16, 2016: Attachment & Human Development
https://www.readbyqxmd.com/read/27851959/identification-of-serotonergic-neuronal-modules-that-affect-aggressive-behavior
#10
Vera Niederkofler, Tedi E Asher, Benjamin W Okaty, Benjamin D Rood, Ankita Narayan, Lara S Hwa, Sheryl G Beck, Klaus A Miczek, Susan M Dymecki
Escalated aggression can have devastating societal consequences, yet underlying neurobiological mechanisms are poorly understood. Here, we show significantly increased inter-male mouse aggression when neurotransmission is constitutively blocked from either of two subsets of serotonergic, Pet1(+) neurons: one identified by dopamine receptor D1(Drd1a)::cre-driven activity perinatally, and the other by Drd2::cre from pre-adolescence onward. Blocking neurotransmission from other Pet1(+) neuron subsets of similar size and/or overlapping anatomical domains had no effect on aggression compared with controls, suggesting subtype-specific serotonergic neuron influences on aggression...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27848079/cabergoline-and-prolactinomas-lack-of-association-between-drd2-polymorphisms-and-response-to-treatment
#11
Cbf Bueno, E B Trarbach, M D Bronstein, A Glezer
BACKGROUND: About 80% of prolactinomas respond to dopamine agonists (DA) with hormonal normalization and tumor shrinkage. Mechanisms of DA resistance include reduction of dopamine receptor subtype 2 (DRD2) expression, short and long isoform ratio and post-receptor mechanisms. It was suggested that polymorphisms in the gene encoding dopamine receptor subtype 2 gene (DRD2) could be associated with variable effectiveness of cabergoline (CAB). OBJECTIVE: To assess the influence of DRD2 polymorphisms in responsiveness of CAB treatment in patients with prolactinoma...
November 15, 2016: Pituitary
https://www.readbyqxmd.com/read/27829443/the-role-of-c957t-taqi-and-ser311cys-polymorphisms-of-the-drd2-gene-in-schizophrenia-systematic-review-and-meta-analysis
#12
REVIEW
Thelma Beatriz González-Castro, Yazmín Hernández-Díaz, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Alma Genis-Mendoza, Mariela Alpuin-Reyes
BACKGROUND: The association between the dopamine D2 receptor (DRD2) gene and schizophrenia has been studied though no conclusive outcomes have been attained. The aim of this study was to perform a systematic review and meta-analysis to explore the relation between three polymorphisms of the DRD2 gene (C957T, TaqI and Ser311Cys) and schizophrenia. METHODS: The search was made in PubMed and EBSCO databases (up to February 2016). The systematic review included 34 case-control association studies (34 for C957T, 16 for TaqI and 36 for Ser311Cys)...
November 9, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27826691/drd2-c957t-polymorphism-is-associated-with-improved-6-month-verbal-learning-following-traumatic-brain-injury
#13
John K Yue, Ethan A Winkler, Jonathan W Rick, John F Burke, Thomas W McAllister, Sam S Oh, Esteban G Burchard, Donglei Hu, Jonathan Rosand, Nancy R Temkin, Frederick K Korley, Marco D Sorani, Adam R Ferguson, Hester F Lingsma, Sourabh Sharma, Caitlin K Robinson, Esther L Yuh, Phiroz E Tarapore, Kevin K W Wang, Ava M Puccio, Pratik Mukherjee, Ramon Diaz-Arrastia, Wayne A Gordon, Alex B Valadka, David O Okonkwo, Geoffrey T Manley
Traumatic brain injury (TBI) often leads to heterogeneous clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism (SNP) in the dopamine D2 receptor (DRD2) may influence cognitive deficits following TBI. However, part of the association with DRD2 has been attributed to genetic variability within the adjacent ankyrin repeat and kinase domain containing 1 protein (ANKK1). Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether a novel DRD2 C957T polymorphism (rs6277) influences outcome on a cognitive battery at 6 months following TBI-California Verbal Learning Test (CVLT-II), Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), and Trail Making Test (TMT)...
November 8, 2016: Neurogenetics
https://www.readbyqxmd.com/read/27819741/association-between-dopamine-d2-receptor-gene-polymorphisms-and-the-risk-of-heroin-dependence
#14
N Wang, J B Zhang, J Zhao, X T Cai, Y S Zhu, S B Li
Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and six polymorphisms of the DRD2 gene using the MassARRAY system. Three hundred and thirty-four patients with heroin dependence and 299 healthy controls participated in the research. Compared with the healthy controls, heroin-dependent patients had a significantly lower frequency of the AA genotype of rs6275 (P = 0...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27817855/association-of-the-drd2-can-str-and-drd3-ser9gly-polymorphisms-with-parkinson-s-disease-and-response-to-dopamine-agonists
#15
Shaoqing Xu, Jiujiang Liu, Xiaodong Yang, Yiwei Qian, Qin Xiao
Dopamine agonists (DAs) play important roles in the treatment of Parkinson's disease (PD). Currently, it is thought that genetic variations in the genes encoding dopamine receptors (DR) are important factors in determining inter-individual variability in drug responses. To investigate the association between Dopamine receptor D type 2 (DRD2) dinucleotide short tandem repeat (CAn-STR) and Dopamine receptor D type 3 (DRD3) Ser9Gly polymorphisms and the risk of PD, as well as the possible reasons for PD patients using different doses of DAs, we recruited 168 idiopathic PD patients and 182 controls...
August 3, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27793702/clinical-and-biological-predictors-of-response-to-electroconvulsive-therapy-ect-a-review
#16
REVIEW
Martina Pinna, Mirko Manchia, Rossana Oppo, Filomena Scano, Gianluca Pillai, Anna Paola Loche, Piergiorgio Salis, Gian Paolo Minnai
Electroconvulsive therapy (ECT), developed in the 30's by Bini and Cerletti, remains a key element of the therapeutic armamentarium in psychiatry, particularly for severe and life-threatening psychiatric symptoms. However, despite its well-established clinical efficacy, the prescription of ECT has declined constantly over the years due to concerns over its safety (cognitive side effects) and an increasingly negative public perception. As for other treatments in the field of psychiatry, ECT is well suited to a personalized approach that would increment its efficacy, as well as reducing the impact of side effects...
October 25, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27786532/relations-between-three-dopaminergic-system-genes-school-attachment-and-adolescent-delinquency
#17
Adam Fine, Alissa Mahler, Cortney Simmons, Chuansheng Chen, Robert Moyzis, Elizabeth Cauffman
Both environmental factors and genetic variation, particularly in genes responsible for the dopaminergic system such as DRD4, DRD2, and DAT1 (SLC6A3), affect adolescent delinquency. The school context, despite its developmental importance, has been overlooked in gene-environment research. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development (NICHD ECCYD), this study examined key interactions between school attachment and (a) each of the DRD4, DRD2, and DAT1 (SLC6A3) genotypes; and (b) a polygenic score...
November 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27785835/a-dense-cluster-of-d1-cells-in-the-mouse-nucleus-accumbens
#18
Sarah Petryszyn, Maria Gabriela Sánchez, Dave Gagnon, Jean-Martin Beaulieu, André Parent, Martin Parent
The striatum is known to be largely composed of intermingled medium-sized projection neurons expressing either the D1 or the D2 dopamine receptors. In the present study, we took advantage of the double BAC Drd1a-TdTomato/Drd2-GFP (D1 /D2 ) transgenic mice to reveal the presence of a peculiar cluster of densely-packed D1 + cells located in the shell compartment of the nucleus accumbens. This spherical cluster has a diameter of 110 µm and is exclusively composed by D1 + cells, which are all immunoreactive for the neuronal nuclear marker (NeuN)...
October 27, 2016: Synapse
https://www.readbyqxmd.com/read/27779245/association-between-drd2-and-drd3-gene-polymorphisms-and-gastrointestinal-symptoms-induced-by-levodopa-therapy-in-parkinson-s-disease
#19
M Rieck, A F Schumacher-Schuh, V Altmann, S M Callegari-Jacques, C R M Rieder, M H Hutz
Levodopa is the most used drug to treat motor symptoms in Parkinson's disease (PD). However, dopaminergic side effects such as nausea and vomiting may occur. Several evidences indicate a major role for dopamine receptors D2 (DRD2) and D3 (DRD3) in emetic activity. The aim of this study was to investigate the relationship of DRD2 rs1799732 and DRD3 rs6280 gene polymorphisms with gastrointestinal (GI) symptoms induced by levodopa in PD patients. Two hundred and seventeen PD patients on levodopa therapy were investigated...
October 25, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27757834/transcriptome-profile-changes-in-mice-with-mptp-induced-early-stages-of-parkinson-s-disease
#20
Anelya Kh Alieva, Elena V Filatova, Anna A Kolacheva, Margarita M Rudenok, Petr A Slominsky, Mikhail V Ugrumov, Maria I Shadrina
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Despite progress in the study of the molecular, genetic, and pathogenic mechanisms of PD, it is unclear which processes trigger the development of the pathology associated with PD. Models of the presymptomatic and early symptomatic stages of PD induced by MPTP have been used to analyze changes in transcriptome profile in brain tissues, to identify specific patterns and mechanisms underlying neurodegeneration in PD. The whole-transcriptome analysis in the brain tissues of the mice with MPTP-induced PD showed that striatum is involved in the pathogenesis in the earliest stages and the processes associated with vesicular transport may be altered...
October 18, 2016: Molecular Neurobiology
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