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https://www.readbyqxmd.com/read/28930381/intraocular-pressure-and-big-bubble-diameter-in-deep-anterior-lamellar-keratoplasty-an-ex-vivo-microscope-integrated-oct-with-heads-up-display-study
#1
Paramjit K Bhullar, Oscar M Carrasco-Zevallos, Alexandria Dandridge, Neel D Pasricha, Brenton Keller, Liangbo Shen, Joseph A Izatt, Cynthia A Toth, Anthony N Kuo
PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artificial anterior chamber connected to a column of balanced salt solution. A surgeon-in-training learned to perform DALK via the BB technique using swept-source microscope-integrated optical coherence tomography (SS-MIOCT) with heads-up display (HUD)...
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28929966/-a-case-with-scalp-pruritus-caused-by-dermanysus-gallinae-order-mesostigmata
#2
Mustafa Şengül, Nida Kaçar, Mehmet Karaca, Sedef Zeliha Öner, Çağrı Ergin
Dermanyssus gallinae is one of the important hematophagous ectoparasite species of poultry like chicken, pigeon and wild bird species. These ectoparasites in the form of nymphs or adults who can not find their hosts are also seen in mammals and even in humans. For this reason, they are considered as important for public health. The ectoparasite causes a clinical condition named gamasoidosis among pet owners and people who live or work close to animal shelters, barns and chicken farms. Pruritus dermatitis is also caused by D...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929902/neurochemical-changes-underpinning-the-development-of-adjunct-therapies-in-recovery-after-stroke-a-role-for-gaba
#3
Ainslie Johnstone, Jacob M Levenstein, Emily L Hinson, Charlotte J Stagg
Stroke is a leading cause of long-term disability, with around three-quarters of stroke survivors experiencing motor problems. Intensive physiotherapy is currently the most effective treatment for post-stroke motor deficits, but much recent research has been targeted at increasing the effects of the intervention by pairing it with a wide variety of adjunct therapies, all of which aim to increase cortical plasticity, and thereby hope to maximize functional outcome. Here, we review the literature describing neurochemical changes underlying plasticity induction following stroke...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28929481/lessons-learned-from-the-total-evacuation-of-a-hospital-after-the-2016-kumamoto-earthquake
#4
Youichi Yanagawa, Hisayoshi Kondo, Takashi Okawa, Fumio Ochi
BACKGROUND: The 2016 Kumamoto Earthquakes were a series of earthquakes that included a foreshock earthquake (magnitude 6.2) on April 14 and a main shock (magnitude 7.0) on April 16, 2016. A number of hospitals in Kumamoto were severely damaged by the two major earthquakes and required total evacuation. METHODS: The authors retrospectively analyzed the activity data of the Disaster Medical Assistance Teams using the Emergency Medical Information System records to investigate the cases in which the total evacuation of a hospital was attempted following the 2016 Kumamoto Earthquake...
July 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28929301/urban-heart-detroit-a-tool-to-better-understand-and-address-health-equity-gaps-in-the-city
#5
R Mehdipanah, A J Schulz, B A Israel, C Gamboa, Z Rowe, M Khan, A Allen
The Urban Health Equity Assessment Response Tool (Urban HEART) combines statistical evidence and community knowledge to address urban health inequities. This paper describes the process of adopting and implementing this tool for Detroit, Michigan, the first city in the USA to use it. The six steps of Urban HEART were implemented by the Healthy Environments Partnership, a community-based participatory research partnership made up of community-based organizations, health service providers, and researchers based in academic institutions...
September 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28929098/the-degree-of-one-health-implementation-in-the-west-nile-virus-integrated-surveillance-in-northern-italy-2016
#6
REVIEW
Giulia Paternoster, Laura Tomassone, Marco Tamba, Mario Chiari, Antonio Lavazza, Mauro Piazzi, Anna R Favretto, Giacomo Balduzzi, Alessandra Pautasso, Barbara R Vogler
West Nile virus (WNV) is endemic in the Po valley area, Northern Italy, and within the legal framework of the national plan for the surveillance of human vector-borne diseases, WNV surveillance has over time been implemented. The surveillance plans are based on the transdisciplinary and trans-sectorial collaboration between regional institutions involved in public, animal, and environmental health. This integrated surveillance targets mosquitoes, wild birds, humans, and horses and aims at early detecting the viral circulation and reducing the risk of infection in the human populations...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28927421/a-25-gene-classifier-predicts-overall-survival-in-resectable-pancreatic-cancer
#7
David J Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier, François Bertucci
BACKGROUND: Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. Because of a strong metastatic propensity, neoadjuvant chemotherapy is being tested in randomized clinical trials. In this context, improving the selection of patients for immediate surgery or neoadjuvant chemotherapy is crucial, and high-throughput molecular analyses may help; the present study aims to address this...
September 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28927325/molecular-imaging-of-hydrolytic-enzymes-using-pet-and-spect
#8
Brian P Rempel, Eric W Price, Christopher P Phenix
Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora of critical biochemical processes required to maintain human health. However, the expression and/or activity of these important enzymes can change in many different diseases and therefore represent exciting targets for the development of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radiotracers. This review focuses on recently reported radiolabeled substrates, reversible inhibitors, and irreversible inhibitors investigated as PET and SPECT tracers for imaging hydrolytic enzymes...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28924815/automatic-determination-of-the-need-for-intravenous-contrast-in-musculoskeletal-mri-examinations-using-ibm-watson-s-natural-language-processing-algorithm
#9
Hari Trivedi, Joseph Mesterhazy, Benjamin Laguna, Thienkhai Vu, Jae Ho Sohn
Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors...
September 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28924003/learning-the-high-dimensional-immunogenomic-features-that-predict-public-and-private-antibody-repertoires
#10
Victor Greiff, Cédric R Weber, Johannes Palme, Ulrich Bodenhofer, Enkelejda Miho, Ulrike Menzel, Sai T Reddy
Recent studies have revealed that immune repertoires contain a substantial fraction of public clones, which may be defined as Ab or TCR clonal sequences shared across individuals. It has remained unclear whether public clones possess predictable sequence features that differentiate them from private clones, which are believed to be generated largely stochastically. This knowledge gap represents a lack of insight into the shaping of immune repertoire diversity. Leveraging a machine learning approach capable of capturing the high-dimensional compositional information of each clonal sequence (defined by CDR3), we detected predictive public clone and private clone-specific immunogenomic differences concentrated in CDR3's N1-D-N2 region, which allowed the prediction of public and private status with 80% accuracy in humans and mice...
September 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28923360/when-theory-and-biology-differ-the-relationship-between-reward-prediction-errors-and-expectancy
#11
Chad C Williams, Cameron D Hassall, Robert Trska, Clay B Holroyd, Olave E Krigolson
Comparisons between expectations and outcomes are critical for learning. Termed prediction errors, the violations of expectancy that occur when outcomes differ from expectations are used to modify value and shape behaviour. In the present study, we examined how a wide range of expectancy violations impacted neural signals associated with feedback processing. Participants performed a time estimation task in which they had to guess the duration of one second while their electroencephalogram was recorded. In a key manipulation, we varied task difficulty across the experiment to create a range of different feedback expectancies - reward feedback was either very expected, expected, 50/50, unexpected, or very unexpected...
September 15, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28923016/5-hydroxymethylcytosine-is-highly-dynamic-across-human-fetal-brain-development
#12
Helen Spiers, Eilis Hannon, Leonard C Schalkwyk, Nicholas J Bray, Jonathan Mill
BACKGROUND: Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory...
September 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28922835/rewards-and-cognitive-control-in-the-human-prefrontal-cortex
#13
Sandrine Duverne, Etienne Koechlin
The human prefrontal cortex (PFC) subserves cognitive control, that is, the ability to form behavioral strategies that coordinate actions and thoughts in relation to internal goals. Cognitive control involves the medial and lateral PFC but we still poorly understand how these regions guide strategy selection according to expected rewards. We addressed this issue using neuroimaging, computational modeling and model-based analyses of information flows between medial and lateral PFC. We show here that the (dorsal) medial PFC encodes and conveys to lateral PFC reward expectations driving strategy selection, while strategy selection originates in lateral PFC and propagates backward to medial PFC...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922115/colour-constancy-beyond-the-classical-receptive-field
#14
Arash Akbarinia, C Alejandro Parraga
The problem of removing illuminant variations to preserve the colours of objects (colour constancy) has already been solved by the human brain using mechanisms that rely largely on centre-surround computations of local contrast. In this paper we adopt some of these biological solutions described by long known physiological findings into a simple, fully automatic, functional model (termed Adaptive Surround Modulation or ASM). In ASM, the size of a visual neuron's receptive field (RF) as well as the relationship with its surround varies according to the local contrast within the stimulus, which in turn determines the nature of the centre-surround normalisation of cortical neurons higher up in the processing chain...
September 18, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28920443/four-fallacies-and-an-oversight-searching-for-martian-life
#15
J D Rummel, C A Conley
While it is anticipated that future human missions to Mars will increase the amount of biological and organic contamination that might be distributed on that planet, robotic missions continue to grow in capability and complexity, requiring precautions to be taken now to protect Mars, and particularly areas of Mars that might be Special Regions. Such precautionary cleanliness requirements for spacecraft have evolved over the course of the space age, as we have learned more about planetary environments, and are the subject of regular deliberations and decisions sponsored by the Committee on Space Research (COSPAR)...
September 16, 2017: Astrobiology
https://www.readbyqxmd.com/read/28919868/the-affective-core-of-the-self-a-neuro-archetypical-perspective-on-the-foundations-of-human-and-animal-subjectivity
#16
REVIEW
Antonio Alcaro, Stefano Carta, Jaak Panksepp
Psychologists usually considered the "Self" as an object of experience appearing when the individual perceives its existence within the conscious field. In accordance with such a view, the self-representing capacity of the human mind has been related to corticolimbic learning processes taking place within individual development. On the other hand, Carl Gustav Jung considered the Self as the core of our personality, in its conscious and unconscious aspects, as well as in its actual and potential forms. According to Jung, the Self originates from an inborn dynamic structure integrating the essential drives of our "brain-mind," and leading both to instinctual behavioral actions and to archetypal psychological experiences...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28919408/neural-oscillations-reflect-latent-learning-states-underlying-dual-context-sensorimotor-adaptation
#17
Justin M Fine, Dalton Moore, Marco Santello
Recent studies have suggested that individuals can form multiple motor memories when simultaneously adapting to multiple, but oppositely-oriented perturbations. These findings predict that individuals detect the change in learning context, allowing the selective initialization and update of motor memories. However, previous electrophysiological studies of sensorimotor adaptation have not identified a neural mechanism supporting the detection of a context switch and adaptation to separate contexts. Here, we tested the hypothesis that such a mechanism is identifiable through neural oscillations measured through EEG...
September 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28919222/understanding-active-sampling-strategies-empirical-approaches-and-implications-for-attention-and-decision-research
#18
REVIEW
Jacqueline Gottlieb
In natural behavior we actively gather information using attention and active sensing behaviors (such as shifts of gaze) to sample relevant cues. However, while attention and decision making are naturally coordinated, in the laboratory they have been dissociated. Attention is studied independently of the actions it serves. Conversely, decision theories make the simplifying assumption that the relevant information is given, and do not attempt to describe how the decision maker may learn and implement active sampling policies...
August 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28919042/new-tools-for-the-visualization-of-biological-pathways
#19
Tomojit Ghosh, Xiaofeng Ma, Michael Kirby
This paper presents several geometrically motivated techniques for the visualization of high-dimensional biological data sets. The Grassmann manifold provides a robust framework for measuring data similarity in a subspace context. Sparse radial basis function classification as a visualization technique leverages recent advances in radial basis function learning via convex optimization. In the spirit of deep belief networks, supervised centroid-encoding is proposed as a way to exploit class label information...
September 14, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28918605/food-or-threat-wild-capuchin-monkeys-sapajus-libidinosus-as-both-predators-and-prey-of-snakes
#20
Tiago Falótico, Michele P Verderane, Olívia Mendonça-Furtado, Noemi Spagnoletti, Eduardo B Ottoni, Elisabetta Visalberghi, Patrícia Izar
Snakes present a hazard to primates, both as active predators and by defensive envenomation. This risk might have been a selective pressure on the evolution of primate visual and cognitive systems, leading to several behavioral traits present in human and non-human primates, such as the ability to quickly learn to fear snakes. Primates seldom prey on snakes, and humans are one of the few primate species that do. We report here another case, the wild capuchin monkey (Sapajus libidinosus), which preys on snakes...
September 16, 2017: Primates; Journal of Primatology
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