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https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#1
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676671/risk-factor-analysis-of-proximal-junctional-kyphosis-after-posterior-osteotomy-in-patients-with-ankylosing-spondylitis
#2
Tianhao Wang, Yongfei Zhao, Yan Liang, Haocong Zhang, Zheng Wang, Yan Wang
OBJECTIVE The aim of this paper was to analyze the incidence and risk factors of proximal junctional kyphosis (PJK) in patients with ankylosing spondylitis (AS) who underwent pedicle subtraction osteotomy. METHODS The records of 83 patients with AS and thoracolumbar kyphosis who underwent surgery at the authors' institution between 2007 and 2013 were reviewed. The patients were divided into 2 groups based on the presence or absence of PJK. The radiographic measurements, including proximal junctional angle (PJA), sagittal parameters, and pelvic parameters of these 2 groups, were compared at different time points: before surgery and 2 weeks, 12 months, and 2 years after surgery...
April 20, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#3
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: J Neuroinflamm Neurodegener Dis
https://www.readbyqxmd.com/read/29675675/adolescent-idiopathic-scoliosis-correction-by-instrumented-vertebral-arthrodesis-with-autologous-bone-graft-from-local-harvesting-without-bone-substitute-use-results-with-mean-3-year-follow-up
#4
Marco Crostelli, Osvaldo Mazza, Massimo Mariani, Dario Mascello, Carlo Iorio
PURPOSE: Bone substitutes' advantage is enhancing arthrodesis biologic support without further autologous bone graft harvested from other skeleton sites, as from posterior iliac crests; however, in our experience, bone substitutes' integration is often incomplete. METHODS: From 2012 to 2017, we operated 108 patients by posterior instrumented vertebral arthrodesis in adolescent idiopathic scoliosis (AIS) correction, mean main curve 80° Cobb, and mean age 12 years and 6 months, with all pedicle screws instrumentation in main curve/curves area and hooks at upper tip of implant; bone graft has been harvested only at vertebral level, without bone substitutes or autologous graft from other patient sites or allogenic bone graft...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29673822/vascularized-spinous-process-graft-rotated-on-a-paraspinous-muscle-pedicle-for-lumbar-fusion-technique-description-and-early-clinical-experience
#5
Michael A Bohl, Kaith K Almefty, Mark C Preul, Jay D Turner, U Kumar Kakarla, Edward M Reece, Steve W Chang
BACKGROUND: Vascularized bone grafts (VBGs) are described as having superior osteogenicity, osteoconductivity, and osteoinductivity compared with other graft types, and have been used in high-risk patients to augment arthrodesis. Pedicled VBGs are rotated on an intact vascular pedicle and therefore maintain all the benefits of VBG, but avoid many of the challenges and additional morbidity of free-tissue transfer. This study describes a novel surgical technique for rotating vascularized spinous process into the posterolateral space for augmenting arthrodesis in patients undergoing posterolateral fusion (PLF)...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673199/thoracic-lumbar-and-sacral-pedicle-screw-placement-using-stryker-ziehm-virtual-screw-technology-and-navigated-stryker-cordless-driver-3-technical-note
#6
Praveen Satarasinghe, Kojo D Hamilton, Michael J Tarver, Robert J Buchanan, Michael T Koltz
OBJECT: Utilization of pedicle screws (PS) for spine stabilization is common in spinal surgery. With reliance on visual inspection of anatomical landmarks prior to screw placement, the free-hand technique requires a high level of surgeon skill and precision. Three-dimensional (3D), computer-assisted virtual neuronavigation improves the precision of PS placement and minimization steps. METHODS: Twenty-three patients with degenerative, traumatic, or neoplastic pathologies received treatment via a novel three-step PS technique that utilizes a navigated power driver in combination with virtual screw technology...
April 17, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29672775/free-or-perforator-pedicled-propeller-flaps-in-lower-extremity-reconstruction-defining-the-coverage-failure
#7
Farid Bekara, Christian Herlin, Antoine De Runz, David Boccara, Benoit Chaput
No abstract text is available yet for this article.
April 19, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29672420/the-arrival-of-robotics-in-spine-surgery-a-review-of-the-literature
#8
Alexander Ghasem, Akhil Sharma, Dylan N Greif, Milad Alam, Motasem Al Maaieh
STUDY DESIGN: Systematic Review. OBJECTIVE: The authors aim to review comparative outcome measures between robotic and free-hand spine surgical procedures including: accuracy of spinal instrumentation, radiation exposure, operative time, hospital stay, and complication rates. SUMMARY OF BACKGROUND DATA: Misplacement of pedicle screws in conventional open as well as minimally invasive surgical procedures has prompted the need for innovation and allowed the emergence of robotics in spine surgery...
April 18, 2018: Spine
https://www.readbyqxmd.com/read/29671110/pulmonary-cement-embolism-following-cement-augmented-fenestrated-pedicle-screw-fixation-in-adult-spinal-deformity-patients-with-severe-osteoporosis-analysis-of-2978-fenestrated-screws
#9
Onur Levent Ulusoy, Sinan Kahraman, Isik Karalok, Emel Kaya, Meric Enercan, Cem Sever, Burak Abay, Selhan Karadereler, Azmi Hamzaoglu
INTRODUCTION: There is very limited information about pulmonary cement embolism (PCE) following cement-augmented fenestrated pedicle screw (CAFPS) fixation in the literature. The aim of this study to report the incidence of PCE following CAFPS fixation in adult deformity patients with severe osteoporosis and to identify risk factors such as; the number of levels, number of screws, and the cement volume used. METHODS: 281 patients (204F, 77M) in whom CAFPS fixation was used during deformity surgery were included...
April 18, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29670905/cortical-bone-trajectory-screws-in-posterior-lumbar-interbody-fusion-minimally-invasive-surgery-for-maximal-muscle-sparing-a-prospective-comparative-study-with-the-traditional-open-technique
#10
Nicola Marengo, Marco Ajello, Michele Federico Pecoraro, Giulia Pilloni, Giovanni Vercelli, Fabio Cofano, Francesco Zenga, Alessandro Ducati, Diego Garbossa
Introduction: A prospective comparative study between classical posterior interbody fusion with peduncular screws and the new technique with divergent cortical screws was conducted. Material and Methods: Only patients with monosegmental degenerative disease were recruited into this study. We analyzed a cohort of 40 patients treated from January 2015 to March 2016 divided into 2 groups (20 patients went to traditional open surgery and 20 patients under mini-invasive strategy)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669577/is-a-patient-specific-drill-template-via-a-cortical-bone-trajectory-safe-in-cervical-anterior-transpedicular-insertion
#11
Peng Peng, Yafei Xu, Xintao Zhang, Meisong Zhu, Bingran Du, Wenrui Li, Wenhua Huang, Jun Song, Jianyi Li
BACKGROUND: This study aimed to develop patient-specific drill templates by computer numerical control or three-dimensional printing via two cortical bone trajectories (CBTs) and to evaluate their efficacies and accuracies in cervical anterior transpedicular insertion. METHODS: Preoperative CT images of 20 cadaveric cervical vertebrae (C3-C7) were obtained. After image processing, patient-specific drill templates were randomly assigned to be constructed via two CBTs (CBT0 and CBT0...
April 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29668632/outcomes-of-using-a-modified-anteromedial-thigh-perforator-flap-for-repairing-the-anterolateral-thigh-free-flap-donor-site-a-retrospective-clinical-review
#12
Xiao Zhou, Jin Wang, Li Qiang, Yongjun Rui, Mingyu Xue
The anterolateral thigh (ALT) flap plays an essential part in plastic and reconstructive surgery. However, repair of the anterolateral donor site has not been the focus of the clinicians.To assess the clinical value and feasibility of using a modified anteromedial thigh (AMT) perforator flap for repairing the ALT free flap donor site.In this retrospective study, 16 ALT flaps were transferred to resurface large soft-tissue defects (ranged from 7 × 5 to 13 × 8 cm) in the foot or hand from June 2012 to March 2013...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668509/a-description-of-the-vascular-anatomy-of-the-tensor-fascia-lata-perforator-flap-using-computed-tomography-angiography
#13
Jeremy M Powers, Mariana Martinez, Shuhao Zhang, Santosh S Kale
BACKGROUND: The perforator anatomy of the tensor fascia lata (TFL) flap has been studied using cadaver dissection; however, exact descriptions of location, size, and origin of perforator vessels using preoperative imaging modalities remain limited. The aims of this study are to describe TFL perforator anatomy using high-resolution computed tomography angiography (CTA) and to correlate these findings with landmarks for the anterolateral thigh flap to facilitate flap planning. METHODS: We identified 33 patients who previously underwent bilateral lower extremity CTAs for preoperative planning of free-flap reconstruction...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29667170/cone-synapses-in-mammalian-retinal-rod-bipolar-cells
#14
Ji-Jie Pang, Zhuo Yang, Roy A Jacoby, Samuel M Wu
Some mammalian rod bipolar cells (RBCs) can receive excitatory chemical synaptic inputs from both rods and cones (DBCR2 ), but anatomical evidence for mammalian cone-RBC contacts has been sparse. We examined anatomical cone-RBC contacts using neurobiotin (NB) to visualize individual mouse cones and standard immuno-markers to identify RBCs, cone pedicles and synapses in mouse and baboon retinas. Peanut agglutinin (PNA) stained the basal membrane of all cone pedicles, and mouse cones were positive for red/green (R/G)-opsin, whereas baboon cones were positive for calbindin D-28k...
April 18, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29667139/spinal-navigation-for-minimally-invasive-thoracic-and-lumbosacral-spine-fixation-implications-for-radiation-exposure-operative-time-and-accuracy-of-pedicle-screw-placement
#15
T Tajsic, K Patel, R Farmer, R J Mannion, R A Trivedi
PURPOSE: Navigation is emerging as a useful adjunct in percutaneous, minimally invasive spinal surgery (MIS). The aim of this study was to compare C-Arm navigated, O-Arm navigated and conventional 2D-fluoroscopy assisted MIS thoracic and lumbosacral spine fixation techniques in terms of operating time, radiation exposure and accuracy of pedicle screw (PS) placement. METHODS: Retrospective observational study of 152 consecutive adults who underwent MIS fixations for spinal instability: 96 2D-fluoroscopy assisted, 39 3D-C-Arm navigated and 27 using O-Arm navigated...
April 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29664831/design-of-mini-latissimus-dorsi-flap-based-on-thoracodorsal-vascular-patterns
#16
Ehab Mostafa Elzawawy, Melad Naim Kelada, Ahmed Farouk Al Karmouty
INTRODUCTION: Latissimus dorsi (LD) flap has been used for reconstructive purposes in oncoplastic breast surgery. Using large part of the muscle as a flap leads to a residual functional loss. Muscle sparing and mini LD flaps can be used with no functional sequelae. However, the design of such flap presents a challenge. METHODS: Twenty cadavers were dissected on both sides to identify the different vascular patterns of the thoracodorsal (TD) pedicle. The vessels were counted, and the following measurements were taken: diameter, length, distance from inferior angel of scapula, and vertebral level...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29664826/repeated-use-of-gluteal-fold-flaps-for-post-oncologic-vulvoperineal-reconstruction
#17
J Joris Hage, Maurits Lange, Henry J Zijlmans, Marc van Beurden
BACKGROUND AND AIM: Because of the associated high recurrence rate, future reconstructive options should be reckoned with during surgical treatment of primary or recurrent (pre)malignant vulvoperineal lesions. One of the claimed advantages of the gluteal fold flap is the possibility of repeated use of the flap in case of recurrence. We present our experience with such reuse of gluteal fold flaps to illustrate this possibility. METHODS: A mean of 27 months after initial use, 10 subcutaneously pedicled or perforator-based V-Y advancement or propeller-rotation flaps were elevated from previously used gluteal fold flaps in 9 women presenting with recurrent vulvoperineal (pre)malignancy...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29664802/free-thoracoacromial-artery-perforator-flap-for-skin-defects-of-the-dorsal-hand
#18
Satoshi Kodaira, Keizo Fukumoto, Naoki Kato
Various flaps are used for skin defects of the dorsal hand and fingers. A sensory flap is not essential, but a thin and good color-matched flap is suitable, and donor site mobility of the flap should be considered. A reverse or free posterior interosseous artery perforator flap is one of the standard flaps. This flap requires no major arterial sacrifice, but direct closure of the donor site is difficult when the width of the flap is >3 cm, and there is also the risk of posterior interosseous nerve injury, especially the motor branch of the extensor carpi ulnaris muscle...
April 16, 2018: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/29664450/quantitative-assessment-of-vertebral-artery-anatomy-in-relation-to-cervical-pedicles-surgical-considerations-based-on-regional-differences
#19
Amro Al-Habib, Fahad Albadr, Jehad Ahmed, Abdulrahman Aleissa, Abdullah Al Towim
OBJECTIVE: To quantify the anatomic relationship between the Cervical pedicle screw (CPS), vertebral artery (VA), and related anatomic structures in the Saudi population. METHODS: This retrospective single center study included 50 consecutive patients (35 males) with normal neck findings on computed tomography angiography performed for trauma or vascular evaluation between 2012 and 2014. Radiologic parameters were assessed and correlated with age, weight, height, and body mass index (BMI)...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29663147/cortical-bone-trajectory-screws-for-circumferential-arthrodesis-in-lumbar-degenerative-spine-clinical-and-radiological-outcomes-of-101-cases
#20
Nicola Marengo, Pedro Berjano, Fabio Cofano, Marco Ajello, Francesco Zenga, Giulia Pilloni, Federica Penner, Salvatore Petrone, Lorenzo Vay, Alessandro Ducati, Diego Garbossa
PURPOSE: The use of cortical bone trajectory (CBT) pedicle screws for circumferential interbody fusion represents a viable alternative for single-level procedure with reduced invasiveness and less tissue destruction than the traditional technique. In addition, CBT screws have a potentially stronger pullout strength because of the greater amount of cortical bone intercepted. Only few series exist evaluating clinical and radiological outcomes of CBT screws. METHODS: This is a retrospective cohort study...
April 16, 2018: European Spine Journal
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