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https://www.readbyqxmd.com/read/29677106/effect-of-propofol-continuous-rate-infusion-on-intravenous-glucose-tolerance-test-in-dogs
#1
Kenichi Maeda, Munehiro Iwasaki, Yuki Itou, Satomi Iwai, Shozo Okano
Hyperglycemia causes perioperative complications and many anesthetics impair glucose metabolism and cause hyperglycemia. We evaluated the effects of propofol on blood glucose metabolism and insulin secretion during an intravenous glucose tolerance test (IVGTT) in dogs. Blood glucose, insulin, triglyceride, cholesterol, and free fatty acid (FFA) levels were measured in dogs during IVGTT in a conscious state and under the effect of 2.0% isoflurane, low-concentration propofol (0.2 mg/kg/min), and high-concentration propofol (0...
April 20, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29677007/near-continuous-glucose-monitoring-makes-glycemic-control-safer-in-icu-patients
#2
Jean-Charles Preiser, Olivier Lheureux, Aurelie Thooft, Serge Brimioulle, Jacques Goldstein, Jean-Louis Vincent
OBJECTIVES: Tight glycemic control using intermittent blood glucose measurements is associated with a risk of hypoglycemia. Glucose concentrations can now be measured near continuously (every 5-15 min). We assessed the quality and safety of glycemic control guided by a near-continuous glucose monitoring system in ICU patients. DESIGN: Prospective, cluster-randomized, crossover study. SETTING: Thirty-five-bed medico-surgical department of intensive care with four separate ICUs...
April 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29676778/indirect-co-cultures-of-healthy-mesenchymal-stem-cells-restore-the-physiological-phenotypic-profile-of-psoriatic-mesenchymal-stem-cells
#3
A Campanati, M Orciani, G Sorgentoni, V Consales, M Mattioli Belmonte, R Di Primio, A Offidani
Psoriasis microenvironment, characterized by an imbalance between Th1/Th17 and Th2 cytokines, influences also mesenchymal stem cells (MSCs) phenotypic profile. MSCs from healthy donors (H-MSCs) can exert a strong paracrine effect by secreting active soluble factors, able to modulate the inflammation in the microenvironment. To evaluate the influence of H-MSCs on MSCs from psoriatic patients (PsO-MSCs), H-MSCs and PsO-MSCs were isolated and characterized. Indirect co-culture of H-MSCs with PsO-MSCs was performed; effects on proliferation and expression of cytokines linked to Th1/Th17 and Th2 pathways were assayed before and after co-culture...
April 20, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29676445/systematic-patient-involvement-for-homebased-outpatient-administration-of-complex-chemotherapy-in-acute-leukemia-and-lymphoma
#4
Katrine S Fridthjof, Peter Kampmann, Anne Dünweber, Jette S Gørløv, Connie Nexø, Lone S Friis, Kristina H Nørskov, Pernille C Welinder, Claus Moser, Lars Kjeldsen, Tom Møller
Based on experience with comprehensive patient involvement, we present data from implementation of portable, programmable infusion pumps (PPP) for home-based chemotherapy administration in patients with acute leukaemia and in lymphoma patients receiving (carmustine, etoposide, cytarabine, melphalan) BEAM regimen. Data from 84 patients, receiving 177 cycles of PPP administered chemotherapy, showed convincing safety with minor equipment errors encountered and with high patient satisfaction. In-hospital days could be reduced with 52% out of a total of 1197 treatment days...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676017/valorization-of-postharvest-discard-of-sweet-cherry-for-the-development-of-dehydrated-fruit-ingredients-compositional-physical-and-mechanical-properties
#5
Lorena Franceschinis, Paula Sette, Daniela Salvatori, Carolina Schebor
BACKGROUND: Sweet cherries are an excellent source of phenolic compounds, which may contribute to a healthy diet. The objective of this work was to generate dehydrated ingredients from postharvest discard of sweet cherries. RESULTS: Four dried ingredients were obtained from discard of fresh sweet cherry (Lapins var.), through the application of an osmotic dehydration pretreatment and freeze- or air-drying. The ingredients showed an important phenolic contribution (2...
April 20, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29675957/endoplasmic-reticulum-stress-induces-spatial-memory-deficits-by-activating-gsk-3
#6
Li Lin, Jie Cao, Shu-Sheng Yang, Zheng-Qi Fu, Peng Zeng, Jiang Chu, Lin-Na Ning, Teng Zhang, Yan Shi, Qing Tian, Xin-Wen Zhou, Jian-Zhi Wang
Endoplasmic reticulum (ER) stress is involved in Alzheimer's disease (AD), but the mechanism is not fully understood. Here, we injected tunicamycin (TM), a recognized ER stress inducer, into the brain ventricle of Sprague-Dawley (SD) rats to induce the unfolded protein response (UPR), demonstrated by the enhanced phosphorylation of pancreatic ER kinase (PERK), inositol-requiring enzyme-1 (IRE-1) and activating transcription factor-6 (ATF-6). We observed that UPR induced spatial memory deficits and impairments of synaptic plasticity in the rats...
April 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29675928/differential-cardiac-sympatho-inhibitory-responses-produced-by-the-agonists-b-ht-933-quinpirole-and-immepip-in-normoglycemic-and-diabetic-pithed-rats
#7
Eduardo Rivera-Mancilla, Alain H Altamirano-Espinoza, Guadalupe Manrique-Maldonado, Belinda Villanueva-Castillo, Carlos M Villalón
This study compared the cardiac sympatho-inhibitory responses produced by agonists at α2 -adrenergic (B-HT 933), dopamine D2 -like (quinpirole) and histamine H3 /H4 (immepip) receptors between normoglycemic and streptozotocin-pretreated (diabetic) pithed rats. Intravenous (i.v.) continuous infusions of B-HT 933, quinpirole or immepip were used in normoglycemic and diabetic pithed rats to analyse their sympatho-inhibitory effects on the electrically-stimulated cardioaccelerator sympathetic outflow. Both in normoglycemic and diabetic animals, B-HT 933 (until 100 μg/kg...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29675923/latent-therapeutic-demand-model-for-the-immunoglobulin-replacement-therapy-of-primary-immune-deficiency-disorders-in-the-usa
#8
J S Stonebraker, J Hajjar, J S Orange
BACKGROUND AND OBJECTIVES: Our research aim is to model latent therapeutic demand (LTD) for the immunoglobulin replacement therapy (IgGRT) of primary immune deficiency disorders (PIDDs) in the USA. Given the high level of variability of IgGRT use and major differences among American and European practices in the management of patients with PIDDs, we develop a USA-specific LTD model for common variable immune deficiency (CVID), hyper IGM syndrome, severe combined immune deficiency, Wiskott-Aldrich syndrome and X-linked agammaglobulinemia (XLA)...
April 20, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29675607/medical-and-financial-burden-of-acute-intermittent-porphyria
#9
Rochus A Neeleman, Margreet A E M Wagenmakers, Rita H Koole-Lesuis, G Sophie Mijnhout, J H Paul Wilson, Edith C H Friesema, Janneke G Langendonk
INTRODUCTION: A small proportion of patients with acute intermittent porphyria (AIP) suffer from recurrent porphyric attacks, with a severely diminished quality of life. In this retrospective case-control study, the burden of disease is quantified and compared among three AIP patient subgroups: cases with recurrent attacks, cases with one or occasional attacks and asymptomatic carriers. METHODS: Data from patient records and questionnaires were collected in patients between 1960 and 2016 at the Erasmus Medical Center, Rotterdam, the Netherlands...
April 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29675402/poor-compliance-with-sepsis-guidelines-in-a-tertiary-care-children-s-hospital-emergency-room
#10
Benjamin Louis Moresco, Clinton Woosley, Morris Sauter, Utpal Bhalala
Objectives: This study aimed to assess factors related to adherence to the Pediatric Advanced Life Support guidelines for severe sepsis and septic shock in an emergency room (ER) of a tertiary care children's hospital. Methods: This was a retrospective, observational study of children (0-18 years old) in The Children's Hospital of San Antonio ER over 1 year with the International Consensus Definition Codes, version-9 (ICD-9) diagnostic codes for "severe sepsis" and "shocks...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29674975/possible-role-of-nadph-oxidase-4-in-angiotensin-ii-induced-muscle-wasting-in-mice
#11
Tomoyasu Kadoguchi, Kazunori Shimada, Hiroshi Koide, Tetsuro Miyazaki, Tomoyuki Shiozawa, Shuhei Takahashi, Tatsuro Aikawa, Shohei Ouchi, Kenichi Kitamura, Yurina Sugita, Al Shahi Hamad, Mitsuhiro Kunimoto, Yayoi Sato-Okabayashi, Koji Akita, Kikuo Isoda, Hiroyuki Daida
Background: Muscle wasting is a debilitating phenotype associated with chronic heart failure (CHF). We have previously demonstrated that angiotensin II (AII) directly induces muscle wasting in mice through the activation of NADPH oxidase (Nox). In this study, we tested the hypothesis that deficiency of NADPH oxidase 4 (Nox4), a major source of oxidative stress, ameliorates AII-induced muscle wasting through the regulation of redox balance. Methods and Results: Nox4 knockout (KO) and wild-type (WT) mice were used...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674727/acute-hyperthermia-inhibits-tgf-%C3%AE-1-induced-cardiac-fibroblast-activation-via-suppression-of-akt-signaling
#12
Masatoshi Narikawa, Masanari Umemura, Ryo Tanaka, Takayuki Fujita, Utako Yokoyama, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura, Yoshihiro Ishikawa
Transforming growth factor-β1 (TGF-β1) induces phenotypic changes in fibroblasts to become myofibroblasts with increased production of extracellular matrix (ECM) components and cytokines. It is also known that excessive activation of myofibroblasts accelerates cardiac fibrosis, remodeling, and thus cardiac dysfunction. However, no effective therapy has been established to prevent this process although recent clinical studies have demonstrated the effectiveness of hyperthermia in cardiac dysfunction. The aim of this study was to examine the molecular mechanism of hyperthermia on TGF-β1-mediated phenotypic changes in cardiac fibroblasts...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674718/tak-733-inhibits-inflammatory-neointimal-formation-by-suppressing-proliferation-migration-and-inflammation-in-vitro-and-in-vivo
#13
Jun-Hee Park, Sang Woo Kim, Min-Ji Cha, Nara Yoon, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Sunhye Shin, Jung-Won Choi, Seahyoung Lee, Soyeon Lim, Ki-Chul Hwang
As a potent and selective allosteric inhibitor of MEK, TAK-733 has been shown to exert anti-cancer effects for a wide range of cancers both in vitro and in vivo. However, its effects on inhibiting growth have never been investigated in the cardiovascular system, where regulation of abnormal vascular smooth muscle cell growth in neointimal hyperplasia is an important area of focus. Angiotensin II was used to mimic inflammatory neointimal hyperplasia in an in vitro environment, and balloon catheter-induced injury with an infusion of angiotensin II was used to generate an in vivo rat restenosis model under inflammatory conditions...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29674588/capillarity-induced-folds-fuel-extreme-shape-changes-in-thin-wicked-membranes
#14
Paul Grandgeorge, Natacha Krins, Aurélie Hourlier-Fargette, Christel Laberty-Robert, Sébastien Neukirch, Arnaud Antkowiak
Soft deformable materials are needed for applications such as stretchable electronics, smart textiles, or soft biomedical devices. However, the design of a durable, cost-effective, or biologically compatible version of such a material remains challenging. Living animal cells routinely cope with extreme deformations by unfolding preformed membrane reservoirs available in the form of microvilli or membrane folds. We synthetically mimicked this behavior by creating nanofibrous liquid-infused tissues that spontaneously form similar reservoirs through capillarity-induced folding...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29674334/p-wave-amplitude-and-pr-changes-in-patients-with-inappropriate-sinus-tachycardia-findings-supportive-of-a-central-mechanism
#15
Michael E Field, Paolo Donateo, Nicola Bottoni, Matteo Iori, Michele Brignole, Ryan T Kipp, Douglas E Kopp, Miguel A Leal, Lee L Eckhardt, Jennifer M Wright, Kathleen E Walsh, Richard L Page, Mohamed H Hamdan
BACKGROUND: The mechanism of inappropriate sinus tachycardia (IST) remains incompletely understood. METHODS AND RESULTS: We prospectively compared 3 patient groups: 11 patients with IST (IST Group), 9 control patients administered isoproterenol (Isuprel Group), and 15 patients with cristae terminalis atrial tachycardia (AT Group). P-wave amplitude in lead II and PR interval were measured at a lower and higher heart rate (HR1 and HR2, respectively). P-wave amplitude increased significantly with the increase in HR in the IST Group (0...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29674328/catastrophic-circulatory-collapse-after-inadvertent-subcutaneous-injection-of-treprostinil
#16
John J Radosevich, Mohan Dutt, Jeremy Feldman
PURPOSE: A case of life-threatening cardiovascular collapse after inadvertent subcutaneous injection of undiluted treprostinil is reported. SUMMARY: A 29-year-old, 76-kg woman with group 1 pulmonary arterial hypertension managed with subcutaneous treprostinil infusion arrived at the emergency department (ED) with headache, nausea, vomiting, and a syncopal episode. Her vital signs were stable on presentation. Admission orders were placed, and the appropriate 3-mL syringe containing 7...
April 19, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29674241/protective-effect-of-betulinic-acid-against-intracerebroventricular-streptozotocin-induced-cognitive-impairment-and-neuronal-damage-in-rats-possible-neurotransmitters-and-neuroinflammatory-mechanism
#17
Madhu Kaundal, Rahul Deshmukh, Mohd Akhtar
BACKGROUND: The purpose of the study was to explore the therapeutic potential of Betulinic acid (BA) in streptozotocin (STZ) induced memory damage in experimental rats. METHODS: STZ (3 mg/kg bilaterally) as intracerebroventrical (icv) route was administered on day 1 and 3 in rats. Donepezil (5 mg/kg/day po), used as standard, and BA (5, 10 and 15 mg/kg/day po) were administered after 1 h of 1st STZ infusion up to 21 days. Object recognition task (ORT) for non-spatial, Morris water maze (MWM) for spatial and locomotor activity were performed to evaluate behavioral changes in rats...
December 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29673795/electrochemotherapy-for-breast-cancer-results-from-the-inspect-database
#18
Louise Wichmann Matthiessen, Mohammed Keshtgar, Pietro Curatolo, Christian Kunte, Eva-Maria Grischke, Joy Odili, Tobian Muir, David Mowatt, James P Clover, Se Hwang Liew, Karin Dahlstroem, Jackie Newby, Valerie Letulé, Eva Stauss, Alison Humphreys, Shramana Banerjee, Annette Klein, Roberta Rotunno, Francesca de Terlizzi, Julie Gehl
BACKGROUND: Cutaneous recurrence from breast cancer can pose a clinical challenge. It might be the only disease site, or could be part of disseminated disease, and often profoundly affects quality of life. Electrochemotherapy is a palliative treatment using electric pulses to locally permeabilize tumor cells and thereby significantly increase bleomycin cytotoxicity. Collaborating with the International Network for Sharing Practice on ElectroChemoTherapy (INSPECT), we consecutively and prospectively accrued data on patients treated with electrochemotherapy for cutaneous metastases from breast cancer...
March 14, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29673564/factors-affecting-the-efficacy-and-safety-of-aminophylline-in-treatment-of-apnea-of-prematurity-in-neonatal-intensive-care-unit
#19
Chaohui Ye, Caiyun Miao, Li Yu, Zhuoya Dong, Jie Zhang, Yingying Mao, Xiaodong Lu, Qin Lyu
BACKGROUND: The factors affecting the safety and efficacy of aminophylline use in the treatment of apnea of prematurity (AOP) in the neonatal intensive care unit (NICU) are not clear. In this study, we aimed to evaluate the potential factors affecting the efficacy and safety of aminophylline in AOP treatment at standard doses and to determine appropriate patients for this therapy. METHODS: Over a 3-year period (January 2012 to December 2014), the medical records of 206 preterm infants with apnea who were admitted to the NICU of our hospital to receive aminophylline infusions were retrospectively reviewed...
March 30, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29673413/seven-cases-of-probable-endotoxin-poisoning-related-to-contaminated-glutathione-infusions
#20
T Johnstone, E Quinn, S Tobin, R Davis, Z Najjar, B Battye, L Gupta
We report seven cases of probable endotoxin poisoning linked to contaminated compounded glutathione. Five of the cases were using the infusions for treatment of Lyme disease highlighting the risks of using compounded sterile preparations for unapproved indications, especially if the quality of source products cannot be assured.
April 20, 2018: Epidemiology and Infection
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