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https://www.readbyqxmd.com/read/29470297/competitively-selected-donor-fecal-microbiota-transplantation-butyrate-concentration-and-diversity-as-measures-of-donor-quality
#1
Danielle Barnes, Katharine Ng, Sam Smits, Justin Sonnenburg, Zain Kassam, K T Park
In this prospective cohort study, we examine the feasibility of a protocol to optimize microbiota for fecal microbiota transplantation (FMT). Donor stool metrics generally accepted as markers of gut health were used to select a stool donor based on superior microbial diversity, balanced constitution of Bacteroidetes versus Firmicutes and high concentration of fecal butyrate. Selected donor microbiota was then administered via FMT. A total of 10 patients with median age of 12 years with recurrent Clostridium difficile infection (rCDI) received the intervention...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29467194/identification-and-characterization-of-clostridium-difficile-genotype-st37-by-maldi-tof-mass-spectrometry
#2
Ruxin Li, Di Xiao, Jing Yang, Suju Sun, Samuel Kaplan, Zhirong Li, Yanan Niu, Cuixin Qiang, Yu Zhai, Xiaoming Wang, Xingzhen Zhao, Baoxin Zhao, Martin Welker, David H Pincus, Dazhi Jin, Mini Kamboj, Guanghui Zheng, Guojun Zhang, Jianzhong Zhang, Yi-Wei Tang, Jianhong Zhao
Clostridium difficile multilocus sequence type 37 (ST37), which mainly corresponds to ribotype 017, has been a dominant genotype circulating in China. In this study, we report the use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to analyze and characterize 204 C. difficile clinical isolates including 49 ST37 and 155 non-ST37 isolates collected in China and other countries. Distribution of two major protein peaks ( m/z 3242 and 3286) was significantly different between ST37 and non-ST37 prototype strains and clinical isolates...
February 21, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29465540/clostridium-difficile-infection-in-hospitalized-patients-with-inflammatory-bowel-disease-prevalence-risk-factors-and-prognosis-erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464969/clostridioides-clostridium-difficile-infection-current-and-alternative-therapeutic-strategies
#4
Fernando Gil, Iván L Calderón, Juan A Fuentes, Daniel Paredes-Sabja
Clostridioides difficile (C. difficile) has become a pathogen of worldwide importance considering that epidemic strains are disseminated in hospitals of several countries, where community-acquired infections act as a constant source of new C. difficile strains into hospitals. Despite the advances in the treatment of infections, more effective therapies against C. difficile are needed but, at the same time, these therapies should be less harmful to the resident gastrointestinal microbiota. The purpose of this review is to present a description of issues associated to C...
February 21, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29463537/impact-of-oral-fidaxomicin-administration-on-the-intestinal-microbiota-and-susceptibility-to-clostridium-difficile-colonization-in-mice
#5
N J Ajami, J L Cope, M C Wong, J F Petrosino, L Chesnel
Clostridium difficile infection (CDI), a common cause of hospital-acquired infections, typically occurs after disruption of the normal gut microbiome by broad-spectrum antibiotics. Fidaxomicin is a narrow-spectrum antibiotic that demonstrates reduced impact on the normal gut microbiota and is approved for the treatment of CDI. To further explore the benefits of this property, we used a murine model to examine the effects of fidaxomicin versus vancomycin on gut microbiota and susceptibility to C. difficile colonization while tracking microbiota recovery over time...
February 20, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29463339/cost-effectiveness-of-competing-treatment-strategies-for-clostridium-difficile-infection-a-systematic-review
#6
Phuc Le, Van T Nghiem, Patricia Dolan Mullen, Abhishek Deshpande
BACKGROUND Clostridium difficile infection (CDI) presents a substantial economic burden and is associated with significant morbidity. While multiple treatment strategies have been evaluated, a cost-effective management strategy remains unclear. OBJECTIVE We conducted a systematic review to assess cost-effectiveness analyses of CDI treatment and to summarize key issues for clinicians and policy makers to consider. METHODS We searched PubMed and 5 other databases from inception to August 2016. These searches were not limited by study design or language of publication...
February 21, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29463185/concomitant-resolution-through-fecal-microbiota-transplantation-of-clostridium-difficile-and-oxa-48-producing-klebsiella-pneumoniae
#7
Giovanni Bruno, Luciano Colangelo, Danilo Badiali, Salvatore Minisola, Enrico Stefano Corazziari, Walter Gianni
No abstract text is available yet for this article.
February 20, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29462695/a-3d-intestinal-tissue-model-supports-clostridioides-difficile-germination-colonization-toxin-production-and-epithelial-damage
#8
Lamyaa Shaban, Ying Chen, Alyssa C Fasciano, Yinan Lin, David L Kaplan, Carol A Kumamoto, Joan Mecsas
Endospore-forming Clostridioides difficile is a causative agent of antibiotic-induced diarrhea, a major nosocomial infection. Studies of its interactions with mammalian tissues have been hampered by the fact that C. difficile requires anaerobic conditions to survive after spore germination. We recently developed a bioengineered 3D human intestinal tissue model and found that low O2 conditions are produced in the lumen of these tissues. Here, we compared the ability of C. difficile spores to germinate, produce toxin and cause tissue damage in our bioengineered 3D tissue model versus in a 2D transwell model in which human cells form a polarized monolayer...
February 17, 2018: Anaerobe
https://www.readbyqxmd.com/read/29462393/increased-rate-of-venous-thromboembolism-in-hospitalized-inflammatory-bowel-disease-patients-with-clostridium-difficile-infection
#9
Sanjay Bhandari, Kia Saeian, Daniel Stein
No abstract text is available yet for this article.
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29462392/venous-thromboembolism-in-hospitalized-inflammatory-bowel-disease-patients-with-clostridium-difficile-infection
#10
Cong Dai, Qin Cao, Ming-Jun Sun
No abstract text is available yet for this article.
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29462386/mice-with-inflammatory-bowel-disease-are-susceptible-to-clostridium-difficile-infection-with-severe-disease-outcomes
#11
Fenfen Zhou, Therwa Hamza, Ashley S Fleur, Yongrong Zhang, Hua Yu, Kevin Chen, Jonathon E Heath, Ye Chen, Haihui Huang, Hanping Feng
Background: Over the past several decades, there has been a significant increase in the incidence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD). However, a wild-type animal model is not available to study these comorbid diseases. Methods: We evaluated the susceptibility to CDI of mice with dextran sulfate sodium salt (DSS)-induced colitis (IBD mice) with or without antibiotic exposure; we examined the histopathology and cytokine response in the concomitant diseases after the model was created...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29462306/a-multicentre-stewardship-initiative-to-decrease-excessive-duration-of-antibiotic-therapy-for-the-treatment-of-community-acquired-pneumonia
#12
Farnaz Foolad, Angela M Huang, Cynthia T Nguyen, Lindsay Colyer, Megan Lim, Jessica Grieger, Julius Li, Sara Revolinski, Megan Mack, Tejal Gandhi, J Njeri Wainaina, Gregory Eschenauer, Twisha S Patel, Vincent D Marshall, Jerod Nagel
Background: The increased emphasis on pneumonia-related performance measures and patient outcomes has led hospitals to implement multifaceted approaches to quickly identify patients with community-acquired pneumonia (CAP), start timely therapy and reduce readmission. However, there has been minimal focus on duration of therapy (DOT) and patients often receive prolonged antibiotic courses. The IDSA and American Thoracic Society (IDSA/ATS) CAP guidelines recommend 5 days of therapy for clinically stable patients that quickly defervesce and stewardship teams are well positioned to influence prescribing practices...
February 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29462280/clinical-practice-guidelines-for-clostridium-difficile-infection-in-adults-and-children-2017-update-by-the-infectious-diseases-society-of-america-idsa-and-society-for-healthcare-epidemiology-of-america-shea
#13
L Clifford McDonald, Dale N Gerding, Stuart Johnson, Johan S Bakken, Karen C Carroll, Susan E Coffin, Erik R Dubberke, Kevin W Garey, Carolyn V Gould, Ciaran Kelly, Vivian Loo, Julia Shaklee Sammons, Thomas J Sandora, Mark H Wilcox
A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment), includes significant changes in the management of this infection and reflects the evolving controversy over best methods for diagnosis...
February 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29460760/artificial-differences-in-clostridium-difficile-infection-rates-associated-with-disparity-in-testing
#14
Mini Kamboj, Jennifer Brite, Anoshe Aslam, Jessica Kennington, N Esther Babady, David Calfee, Yoko Furuya, Donald Chen, Michael Augenbraun, Belinda Ostrowsky, Gopi Patel, Monica Mircescu, Vivek Kak, Roman Tuma, Teresa A Karre, Deborah A Fry, Yola P Duhaney, Amber Moyer, Denise Mitchell, Sherry Cantu, Candace Hsieh, Nancy Warren, Stacy Martin, Jill Willson, Jeanne Dickman, Julie Knight, Kim Delahanty, Annemarie Flood, Jennifer Harrington, Deborah Korenstein, Janet Eagan, Kent Sepkowitz
In 2015, Clostridium difficile testing rates among 30 US community, multispecialty, and cancer hospitals were 14.0, 16.3, and 33.9/1,000 patient-days, respectively. Pooled hospital onset rates were 0.56, 0.84, and 1.57/1,000 patient-days, respectively. Higher testing rates may artificially inflate reported rates of C. difficile infection. C. difficile surveillance should consider testing frequency.
March 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29460560/-isolation-precautions-in-multi-drug-resistent-infections-and-nursing-workload-in-a-general-intensive-care-unit
#15
Stefano Elli, Luigi Cannizzo, Giuseppe Foti, Roberto Fumagalli, Alberto Lucchini
BACKGROUND: Critically ill patients in ICU are exposed to high risk of hospital acquired infections. In recent years, the multi drug resistant microorganisms (MDR) represent the most worrying epidemiological problem. AIM: The aim of this study is to evaluate the relationship between isolation precautions and nursing workload. METHODS: We studied patients who had an infection by MDR, subject to isolation precautions, and measured their NAS score during stay in ICU...
October 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29459965/increasing-incidence-of-multiply-recurrent-clostridium-difficile-infection
#16
Gene K Ma, James D Lewis
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29459964/increasing-incidence-of-multiply-recurrent-clostridium-difficile-infection
#17
Jodie A Barkin, Neil Stollman, Jamie S Barkin
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29459963/increasing-incidence-of-multiply-recurrent-clostridium-difficile-infection
#18
Mark Wilcox
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29459891/evaluating-the-sporicidal-activity-of-disinfectants-against-clostridium-difficile-and-bacillus-amyloliquefaciens-spores-by-using-the-improved-methods-based-on-astm-e2197-11
#19
Marie Christine Uwamahoro, Richard Massicotte, Yves Hurtubise, François Gagné-Bourque, Akier Assanta Mafu, L'Hocine Yahia
Spore-forming pathogenic bacteria, such as Clostridium difficile , are associated with nosocomial infection, leading to the increased use of sporicidal disinfectants, which impacts socioeconomic costs. However, C. difficile can be prevented using microorganisms such as Bacillus amyloliquefaciens , a prophylactic agent that has been proven to be effective against it in recent tests or it can be controlled by sporicidal disinfectants. These disinfectants against spores should be evaluated according to a known and recommended standard...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29457584/immunological-stability-of-clostridium-difficile-toxins-in-clinical-specimens
#20
Donna M Schora, Lance R Peterson, Elena A Usacheva
OBJECTIVE The impact of storage on stability and detection of Clostridium difficile toxins in feces is poorly understood. The objective of this study was to investigate the immunological stability of C. difficile toxins in clinical stool specimens under different storage conditions by evaluating this stability using toxin detection by enzyme immunoassay (EIA). METHODS Stool specimens positive for C. difficile infection (CDI) by quantitative polymerase chain reaction (qPCR) were used for EIA testing with the C...
February 19, 2018: Infection Control and Hospital Epidemiology
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