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https://www.readbyqxmd.com/read/28724616/marburg-virus-survivor-immune-responses-are-th1-skewed-with-limited-neutralizing-antibody-responses
#1
Spencer W Stonier, Andrew S Herbert, Ana I Kuehne, Ariel Sobarzo, Polina Habibulin, Chen V Abramovitch Dahan, Rebekah M James, Moses Egesa, Stephen Cose, Julius Julian Lutwama, Leslie Lobel, John M Dye
Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune responses. Immune responses in survivors of Ebola virus (EBOV) and Sudan virus (SUDV) infections have provided the most insight, with T cell responses as well as detailed antibody responses having been characterized. Immune responses to Marburg virus (MARV), however, remain almost entirely uncharacterized...
July 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28722538/dispersed-synthesis-of-uniform-fe3o4-magnetic-nanoparticles-via-in-situ-decomposition-of-iron-precursor-along-cotton-fiber-for-sudan-dyes-analysis-in-food-samples
#2
Yassine Bentahir, Said Elmarhoum, Rachid Salghi, Manuel Algarra, Angel Ríos, Mohammed Zougagh
Fe3O4 magnetic nanoparticles, with a negative charge surface, are known to have efficient adsorbent properties, but they tend to be agglomerated into larger aggregates or flocs, which can cause loss of specific area. The addition of cotton fiber, as a stabilizer in preparation of the Fe3O4 nanoparticles, is able to efficiently reduce particle aggregation, and thus, effective particle size, resulting in much greater specific surface area and adsorption sites. Fe3O4 nanoparticles synthesis was accomplished by in-situ high temperature decomposition of the precursor ferric ion in the presence of cotton fiber and ethylene glycol solvent...
July 19, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28719276/high-hepatitis-e-seroprevalence-among-displaced-persons-in-south-sudan
#3
Andrew S Azman, Malika Bouhenia, Anita S Iyer, John Rumunu, Richard Lino Laku, Joseph F Wamala, Isabel Rodriguez-Barraquer, Justin Lessler, Etienne Gignoux, Francisco J Luquero, Daniel T Leung, Emily S Gurley, Iza Ciglenecki
AbstractLarge protracted outbreaks of hepatitis E virus (HEV) have been documented in displaced populations in Africa over the past decade though data are limited outside these exceptional settings. Serological studies can provide insights useful for improving surveillance and disease control. We conducted an age-stratified serological survey using samples previously collected for another research study from 206 residents of an internally displaced person camp in Juba, South Sudan. We tested serum for anti-HEV antibodies (IgM and IgG) and estimated the prevalence of recent and historical exposure to the virus...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719270/mycetoma-madura-foot-in-israel-recent-cases-and-a-systematic-review-of-the-literature
#4
Ohad Bitan, Yonit Wiener-Well, Rina Segal, Eli Schwartz
AbstractMycetoma is a chronic soft tissue infection caused by fungal or bacterial pathogens, and is endemic in tropical and subtropical regions. Cases in developed countries outside the mycetoma belt are rare and usually imported by immigrants. Sporadic cases have been reported in Israel. Unpublished cases in the participating medical centers are reported. In addition, a systematic review of the literature was performed. All published mycetoma cases diagnosed in Israel were included with relevant variables collected...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717601/investigation-on-papillomavirus-infection-in-dromedary-camels-in-al-ahsa-saudi-arabia
#5
Abdelmalik Ibrahim Khalafalla, Ramadan Omer Ramadan, Annabel Rector, Seif Barakat
We investigated two outbreaks of papillomatosis between 2013 and 2015 in Al Ahsa region of eastern Saudi Arabia involving fourteen dromedary camels. The disease affected both young and adult animals and occurred in coincidence with demodectic mange infestation. Diagnosis was made based on gross and histopathological characteristics of the wart lesion and was confirmed by PCR. Rolling circle amplification followed by degenerate primer PCR and sequencing of the amplicons revealed the presence of both Camelus dromedarius papillomavirus types 1 and 2, previously identified in infected dromedaries in Sudan...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28713911/glucagon-like-peptide-1-analogue-liraglutide-ameliorates-atherogenesis-via-inhibiting-advanced-glycation-end-product-induced-receptor-for-advanced-glycosylation-end-product-expression-in-apolipoprotein-e-deficient-mice
#6
Peicheng Li, Zhaosheng Tang, Lin Wang, Bo Feng
Glucagon-like peptide-1 (GLP-1) can protect arteriosclerotic lesions in apolipoprotein-E deficient (ApoE-/-) mice. Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) interaction serves a key role in the development of diabetic vascular complications. The present study examined whether the GLP-1 analogue liraglutide can ameliorate atherogenesis via inhibiting AGEs-induced RAGE expression. Male ApoE-/- mice (age, 10 weeks) were divided into control, GLP-1, AGEs and AGEs+GLP-1 group...
July 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713577/seroprevalence-of-spotted-fever-group-sfg-rickettsiae-infection-in-domestic-ruminants-in-khartoum-state-sudan
#7
Nagwa M Eisawi, Dina A Hassan, Mohammed O Hussien, Azza B Musa, Abdel Rahim M El Hussein
Spotted fever group (SFG) rickettsiosis is caused by obligatory intracellular Gram-negative bacteria that belong to the genus Rickettsia. Ticks belonging to the family Ixodidae can act as vectors, reservoirs or amplifiers of SFG rickettsiae. This study was conducted to estimate the seroprevalence of SFG rickettsioses in cattle, sheep and goats from Khartoum State, Sudan. Blood samples were collected from a total of 600 animals (sheep, goats and cattle) from 32 different farms distributed in three locations in Khartoum State during the period January to December 2012...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28710808/the-application-of-physiologically-based-pharmacokinetic-modelling-to-assess-the-impact-of-antiretroviral-mediated-drug-drug-interactions-on-piperaquine-antimalarial-therapy-during-pregnancy
#8
Olusola Olafuyi, Michael Coleman, Raj K S Badhan
Antimalarial therapy during pregnancy poses important safety concerns due to potential teratogenicity and maternal physiological and biochemical changes during gestation. Piperaquine (PQ) has gained interest for use in pregnancy in response to increasing resistance towards sulfadoxine-pyrimethamine in sub-Saharan Africa. Co-infection with HIV is common in many developing countries, however, little is known about the impact of anti-retroviral (ARV) mediated drug-drug interaction (DDI) on PQ pharmacokinetics during pregnancy...
July 14, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28706920/obesity-among-sudanese-adults-with-diabetes-a-population-based-survey
#9
Yasmeen A Ali, Ahmed O Almobarak, Heitham Awadalla, Wadie M Elmadhoun, Mohamed H Ahmed
BACKGROUND: The aim of this study was to determine the prevalence of obesity among Sudanese individuals with diabetes. METHODS: Demographic and clinical data from 1,337 individuals with type 2 diabetes were collected using a pretested, standardized, interviewer administered questionnaire. Subjects were recruited from three states namely Khartoum, Northern and River Nile States. Anthropometric measurements including body weight, height and waist circumference were determined using standardized techniques and calibrated equipment...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28705469/systematic-prioritization-of-functional-hotspot-in-rig-1-domains-using-pattern-based-conventional-molecular-dynamic-simulation
#10
P Raghuraman, R Jesu Jaya Sudan, J Lesitha Jeeva Kumari, C Sudandiradoss
BACKGROUND: Retinoic acid inducible gene 1 (RIG-1), multi-domain protein has a role-play in detecting viral nucleic acids and stimulates the antiviral response. Dysfunction of this protein due to mutations makes the route vulnerable to viral diseases. AIM: Identification of functional hotspots that maintains conformational stability in RIG-1 domains. METHODS: In this study, we employed a systematic in silico strategy on RIG-1 protein to understand the mechanism of structural changes upon mutation...
July 10, 2017: Life Sciences
https://www.readbyqxmd.com/read/28702039/ceres-maize-model-for-determining-the-optimum-planting-dates-of-early-maturing-maize-varieties-in-northern-nigeria
#11
Adnan A Adnan, Jibrin M Jibrin, Alpha Y Kamara, Bassam L Abdulrahman, Abdulwahab S Shaibu, Ismail I Garba
Field trials were carried out in the Sudan Savannah of Nigeria to assess the usefulness of CERES-maize crop model as a decision support tool for optimizing maize production through manipulation of plant dates. The calibration experiments comprised of 20 maize varieties planted during the dry and rainy seasons of 2014 and 2015 at Bayero University Kano and Audu Bako College of Agriculture Dambatta. The trials for model evaluation were conducted in 16 different farmer fields across the Sudan (Bunkure and Garun-Mallam) and Northern Guinea (Tudun-Wada and Lere) Savannas using two of the calibrated varieties under four different sowing dates...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28701857/laparoscopic-single-site-inguinal-hernia-repair-using-a-self-fixating-mesh
#12
Alfredo D Guerron, Hui-Jie Lee, Jin Yoo, Keri Seymour, Ranjan Sudan, Dana Portenier, Chan Park
BACKGROUND AND OBJECTIVES: Every year ∼20 million inguinal hernia repairs are completed worldwide. Increased patient access to medical information and education has elicited interest in minimally invasive surgical techniques that obtain improved surgical outcomes and cosmesis. Because of these factors, there is a growing interest in single-incision surgery. Laparoscopic totally extraperitoneal (TEP) single-incision hernia repair technique has been reported with different meshes used in a tack fixation system...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28698785/haptoglobin-phenotypes-and-susceptibility-to-schistosoma-parasites-infection-in-central-sudan
#13
Ashraf Siddig Yousif, Atif Abdelrahman Elagib
Haptoglobin (Hp) is an acute phase protein that binds the free hemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has antioxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1, and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study, we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28698743/higher-rate-of-iron-deficiency-in-obese-pregnant-sudanese-women
#14
Wisal Abbas, Ishag Adam, Duria A Rayis, Nada G Hassan, Mohamed F Lutfi
AIM: To assess the association between obesity and iron deficiency (ID). MATERIAL AND METHODS: Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during January-April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire. Weight and height were measured, and body mass index (BMI) was calculated. Women were sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5-24.9 kg/m^2), overweight (25-29...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28691730/effects-of-colocynth-alkaloids-and-glycosides-on-wistar-rats-fed-high-fat-diet-a-biochemical-and-morphological-study
#15
Zahia Birem, Khadidja Tabani, Farid Lahfa, Rabah Djaziri, Fatima Hadjbekkouche, Elhadj Ahmed Koceir, Naima Omari
INTRODUCTION: . In traditional medicine, Citrullus colocynthis is used to treat diabetes, hyperlipidemia, cardiovascular diseases, inflammation, and oxidative stress, all of which can appear when a diet rich in vegetable fats, such as palm oil, is continuously consumed. Such high-fat diets are chronic stressors of the hypothalamic-pituitary-adrenal axis. The objective of our study was to analyze and evaluate the effects of colocynth total alkaloids and glycosides on metabolic, hormonal, and structural disorders of the adrenal medulla in Wistar rats fed a high-fat diet...
July 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28690885/cancer-research-in-the-arab-world-a-review-of-publications-from-seven-countries-between-2000-2013
#16
REVIEW
Randah R Hamadeh, Saif M Borgan, Abla M Sibai
This review aimed to examine trends in cancer research in the Arab world and identify existing research gaps. A search of the MEDLINE® database (National Library of Medicine, Bethesda, Maryland, USA) was undertaken for all cancer-related publications published between January 2000 and December 2013 from seven countries, including Bahrain, Kuwait, Iraq, Lebanon, Morocco, Palestine and Sudan. A total of 1,773 articles were identified, with a significant increase in yearly publications over time (P <0.005)...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28690170/polyhydroxybutyrate-by-streptomyces-sp-production-and-characterization
#17
Sivakumar Krishnan, Gandhi Shree Chinnadurai, Palani Perumal
A total number of 20 actinomycetes isolates were isolated from soil sediments obtained from Semmancheri coastal areas of Bay of Bengal, India and they were qualitatively screened for the production of polyhydroxybutyrate (PHB) on a medium containing Sudan black stain. Nine of the 20 isolates produced PHB and the quantity of PHB produced varied from 1.79 to 4.26g(-L). Among the positive isolates an actinomycete isolate which was identified as Streptomyces sp. through 16S rRNA sequencing analysis (Accession No: KF667247) produced relatively higher PHB than other positive isolates...
July 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28685565/a-reversible-colorimetric-sensor-for-moisture-detection-in-organic-solvents-and-application-in-ink-less-writing
#18
Pawan Kumar, Rahul Sakla, Amrita Ghosh, D Amilan Jose
Colorimetric sensors based on Sudan- III (1) and Alizarin Red S (2) have been developed for the detection of a trace amount of water in organic solvents such as THF, acetone, acetonitrile and DMSO. The deprotonated (anionic) forms of 1 and 2 such as 1.F and 2.F are re-protonated by using a trace amount of water. Deprotonation of 1 and 2 were obtained by using fluoride anion. Test papers of 1.F and 2.F in organic solvents with and without moisture showed dramatic changes in color. Receptor 1.F exhibits high sensitivity for water in acetone and THF with the detection limit as low as 0...
July 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28684586/exposure-to-intermittent-hypoxia-and-sustained-hypercapnia-reduces-therapeutic-cpap-in-participants-with-obstructive-sleep-apnea
#19
Mohamad El-Chami, Sukhesh Sudan, Ho-Sheng Lin, Jason H Mateika
PURPOSE: To determine if exposure to mild intermittent hypoxia leads to a reduction in the therapeutic continuous positive airway pressure required to eliminate breathing events. METHODS: Ten male participants were treated with twelve 2-minute episodes of hypoxia (PETO2 ≈ 50 mmHg) separated by 2-minute intervals of normoxia in the presence of PETCO2 that was sustained 3 mmHg above baseline. During recovery from the last episode the positive airway pressure was reduced in a step-wise fashion until flow limitation was evident...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684567/first-report-and-complete-genome-sequence-of-alfalfa-enamovirus-from-sudan
#20
Lev G Nemchinov, Samuel C Grinstead, Dimitre S Mollov
We report the complete genome sequence of a viral pathogen detected in alfalfa samples from Sudan and provisionally named alfalfa enamovirus 2 (AEV-2). Based on high nucleotide and amino acid identities, AEV-2 represents a strain of a newly discovered alfalfa enamovirus 1 that has only been described in Argentina.
July 6, 2017: Genome Announcements
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