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thymoquinone cancer

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https://www.readbyqxmd.com/read/29277983/thymoquinone-can-improve-neuronal-survival-and-promote-neurogenesis-in-rat-hippocampal-neurons
#1
Merve Beker, Tuğçe Dallı, Birsen Elibol
SCOPE: Thymoquinone (TQ) has been used as a potential therapeutic for diseases such as cancer, and diabetes. Herein, we aimed to investigate the effect of TQ on behavioral and molecular parameters in healthy rat hippocampus. METHODS: TQ (20 mg/kg/day) was administered intragastrically for 15 days to adult rats. After the behavioral tests, the hippocampal tissues were investigated in histological and molecular level. RESULTS: In both DG and CA1, TQ significantly increased the number of hippocampal neurons...
December 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29229873/thymoquinone-induces-cytotoxicity-and-reprogramming-of-emt-in-gastric-cancer-cells-by-targeting-pi3k-akt-mtor-pathway
#2
Li-Min Feng, Xue-Feng Wang, Qing-Xian Huang
Gastric cancer is one of the lethal causes of cancer-related deaths worldwide. The incidence and mortality rates of this disease is comparatively higher in China. In the current study, we evaluated the anticancer effects of Thymoquinone (TQ) against gastric cancer cells (MGC80-3 and SGC-7901) and normal noncancerous GES-1 cells and attempted to investigate the underlying mechanism. Our results indicated that TQ exhibited significant growth inhibitory effects on gastric cancer cells (MGC80-3 and SGC-7901). However, lower cytotoxicity was observed against normal GES-1 cells...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29223554/oral-administration-of-nigella-sativa-oil-and-thymoquinone-attenuates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney
#3
Zeba Farooqui, Faaiza Shahid, Aijaz Ahmed Khan, Farah Khan
Cisplatin (CP) is an effective anti-cancer drug which causes remarkable toxicity to the kidney, particularly to proximal tubules, by generating reactive oxygen species. Nigella sativa (NS), commonly known as "black cumin" reduces the progression of various kidney disorders. Thymoquinone (TQ), the major bioactive constituent of NS seeds, has been credited for various pharmacological effects of NS. Since, a typical clinical CP dosing regimen involves CP administration in multiple cycles over a long time duration, hence the present study aimed to evaluate the renoprotective efficacy of NS oil and TQ against multiple dose CP treatment induced deleterious biochemical and histological alterations in rat kidney...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29207526/thymoquinone-inhibits-the-migration-and-invasive-characteristics-of-cervical-cancer-cells-siha-and-caski-in-vitro-by-targeting-epithelial-to-mesenchymal-transition-associated-transcription-factors-twist1-and-zeb1
#4
Jun Li, Md Asaduzzaman Khan, Chunli Wei, Jingliang Cheng, Hanchun Chen, Lisha Yang, Iqra Ijaz, Junjiang Fu
Cervical cancer is one of the most common gynecological malignant tumors worldwide, for which chemotherapeutic strategies are limited due to their non-specific cytotoxicity and drug resistance. The natural product thymoquinone (TQ) has been reported to target a vast number of signaling pathways in carcinogenesis in different cancers, and hence is regarded as a promising anticancer molecule. Inhibition of epithelial to mesenchymal transition (EMT) regulators is an important approach in anticancer research. In this study, TQ was used to treat the cervical cancer cell lines SiHa and CaSki to investigate its effects on EMT-regulatory proteins and cancer metastasis...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29189187/thymoquinone-tq-a-potential-therapeutic-molecule-role-of-colloidal-carriers-in-its-effective-delivery
#5
Poonam Negi, Charul Rathore, Gajanand Sharma, Bhupinder Singh Bhoop, Om Prakash Katare
From the past few decades, remarkable awareness has been laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella sativa (NS) plant has been extensively explored and revealed an array of therapeutic benefits in different in vitro and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ and NS viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastro-protective, hepato-protective, anti-microbial and anti-histaminic...
November 29, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29162539/modulation-of-diverse-oncogenic-transcription-factors-by-thymoquinone-an-essential-oil-compound-isolated-from-the-seeds-of-nigella-sativa-linn
#6
REVIEW
Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Lingzhi Wang, Boon Cher Goh, Kwang Seok Ahn, Anupam Bishayee, Gautam Sethi
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have promising effects against a variety of inflammatory diseases and cancer. Cancer development is a multistep process where normal cells acquire qualities that enable the cells to proliferate continuously and migrate to distant sites in the human body. Drugs that interfere with this process are considered potential anti-cancer therapeutics, which may ultimately result in their clinical usage...
November 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29156767/enhancing-conventional-chemotherapy-drug-cisplatin-induced-anti-tumor-effects-on-human-gastric-cancer-cells-both-in-vitro-and-in-vivo-by-thymoquinone-targeting-pten-gene
#7
Jingjing Ma, Xue Hu, Jiao Li, Dandan Wu, Qingzhi Lan, Qian Wang, Shan Tian, Weiguo Dong
Combination chemotherapy regimen with several anti-tumor drugs is a strategy to improve outcome. Thymoquinone (TQ) has been reported to exert biological activity on various types of human cancers without obvious toxicity. However, only few studies showed the anti-tumor effects of TQ combination with cisplatin on gastric cancer (GC). Here, we showed pretreatment with 5μM TQ significantly increased the apoptotic effects induced by cisplatin on GC cell lines. Combined treatment of cisplatin with TQ represented a significantly superior tumor suppression effect than either agent alone in a xenograft tumor mouse model...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29075062/antiproliferative-and-apoptosis-inducing-activities-of-thymoquinone-in-lymphoblastic-leukemia-cell-line
#8
Amin Soltani, Batoul Pourgheysari, Hedayatollah Shirzad, Zahra Sourani
Acute lymphoblastic leukemia is one of the malignant proliferations of lymphoid cells in the early stages of differentiation and accounts for about 80% of all cases of childhood leukemia. Side effects of available treatment are still main concern. Thymoquinone (TQ), a natural compound isolated from Nigella sativa, induces growth inhibition and apoptosis in several cancer cell lines. The aim of the present study was to investigate the effect of TQ alone and in combination with doxorubicine on the proliferation inhibition and apoptosis induction of TQ in a lymphoblastic leukemia cell line...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29039572/thymoquinone-inhibits-epithelial-mesenchymal-transition-in-prostate-cancer-cells-by-negatively-regulating-the-tgf-%C3%AE-smad2-3-signaling-pathway
#9
Bo Kou, Wei Liu, Wei Zhao, Peng Duan, Yang Yang, Qiuyue Yi, Fengwei Guo, Jianpeng Li, Jinsong Zhou, Qingshan Kou
Thymoquinone, a major ingredient of black seed oil (Nigella sativa), has been shown to exhibit anticancer capacity in various types of cancers. However, there are few studies concerning the correlation between thymoquinone and epithelial-to-mesenchymal transition (EMT) in prostate cancer. In the present study, we firstly found that thymoquinone showed antimetastatic capacity in prostate cancer DU145 and PC3 cells. Additionally, thymoquinone reversed EMT by increasing E-cadherin expression and decreasing vimentin and Slug expression in a concentration-dependent manner...
October 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28983249/therapeutic-potential-and-pharmaceutical-development-of-thymoquinone-a-multitargeted-molecule-of-natural-origin
#10
REVIEW
Sameer N Goyal, Chaitali P Prajapati, Prashant R Gore, Chandragouda R Patil, Umesh B Mahajan, Charu Sharma, Sandhya P Talla, Shreesh K Ojha
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known as black cumin or black seed and belongs to the family Ranunculaceae. A large number of studies have revealed that thymoquinone is the major active constituent in N. sativa oil this constituent is responsible for the majority of the pharmacological properties. The beneficial organoprotective activities of thymoquinone in experimental animal models of different human diseases are attributed to the potent anti-oxidant and anti-inflammatory properties...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28890201/enhanced-anticancer-effect-and-reduced-toxicity-of-doxorubicin-in-combination-with-thymoquinone-released-from-poly-n-acetyl-glucosamine-nanomatrix-in-mice-bearing-solid-ehrlish-carcinoma
#11
Nahla E El-Ashmawy, Eman G Khedr, El-Zeiny M Ebeid, Mohamed L Salem, Abdel-Aziz A Zidan, Esraa M Mosalam
The incidence of breast cancer remarkably increases all over the world. Therefore, there is a great demand to introduce new approaches into cancer treatment field. The current study was designated to evaluate the role of doxorubicin (DOX) and/or thymoquinone (TQ) nanomatrix in potentiating the cytotoxicity of either drug, and to investigate the ability of TQ to reduce cardiotoxicity of DOX in solid Ehrlich carcinoma (SEC)-bearing mice. DOX and TQ were loaded into F2 gel, which is a fully-acetylated poly-N-acetyl glucosamine nanofiber...
September 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28881699/thymoquinone-as-an-anticancer-molecule-from-basic-research-to-clinical-investigation
#12
REVIEW
Md Asaduzzaman Khan, Mousumi Tania, Shangyi Fu, Junjiang Fu
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28707601/potential-role-of-natural-compounds-as-anti-angiogenic-agents-in-cancer
#13
Muthu K Shanmugam, Sudha Warrier, Alan Prem Kumar, Gautam Sethi, Frank Arfuso
BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28693287/effect-of-thymoquinone-on-head-and-neck-squamous-cell-carcinoma-cells-in-vitro-synergism-with-radiation
#14
Ulana Kotowski, Gregor Heiduschka, Lorenz Kadletz, Tammer Fahim, Rudolf Seemann, Rainer Schmid, Sven Schneider, Andreas Mitterbauer, Dietmar Thurnher
Thymoquinone (TQ) is the main bioactive constituent present in black seed oil (Nigella sativa); it has shown anti-inflammatory and anti-neoplastic effects in various cancer cell types. The aim of the present study was to investigate the effects of TQ on head and neck squamous cell carcinoma (HNSCC) cell lines, on its own and in combination with radiation and cisplatin, respectively. The SCC25 and CAL27 HNSCC cell lines were treated with TQ alone and in combination with cisplatin or radiation, respectively. Proliferation assays and clonogenic assays were performed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692636/the-effect-of-thymoquinone-on-apoptosis-of-sk-ov-3-ovarian-cancer-cell-by-regulation-of-bcl-2-and-bax
#15
Xiaoli Liu, Jinhu Dong, Wangyu Cai, Ying Pan, Ruili Li, Bing Li
OBJECTIVE: We aim to determine how cisplatin, thymoquinone (TQ), and combination regimen can affect apoptosis of cultured SK-OV-3 cells. We also want to explore the mechanism of these influences on the cells' apoptosis by Bcl-2 and Bax gene. METHOD/MATERIALS: Cell Counting Kit-8 assay was used to measure the viability of cultured ovarian cancer cells. Propidium iodide with flow cytometry was used in cell cycle analysis. Thereafter, we used fluorescein isothiocyanate-stained annexin V and propidium iodide to detect the effect of cisplatin, TQ, and combination regimen on apoptosis...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28671634/regressions-of-breast-carcinoma-syngraft-following-treatment-with-piperine-in-combination-with-thymoquinone
#16
Wamidh H Talib
Thymoquinone (TQ) and piperine, the active ingredients in cumin (Nigella sativa) and black pepper (Piper longum), respectively, exhibit various bioactivities including anticancer effects. The aim of the present study is to investigate the antineoplastic activity of a combination of TQ and piperine against breast cancer implanted in mice. The antiproliferative effects of TQ, piperine, and a combination of both agents were tested against mouse epithelial breast cancer cell line (EMT6/P) using MTT assay. The isobolographic method was used to calculate the combination index (CI)...
July 3, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28661475/protein-kinase-a-activation-by-the-anti-cancer-drugs-abt-737-and-thymoquinone-is-caspase-3-dependent-and-correlates-with-platelet-inhibition-and-apoptosis
#17
Natalia Rukoyatkina, Elke Butt, Hariharan Subramanian, Viacheslav O Nikolaev, Igor Mindukshev, Ulrich Walter, Stepan Gambaryan, Peter M Benz
Chemotherapy-induced thrombocytopenia is a common bleeding risk in cancer patients and limits chemotherapy dose and frequency. Recent data from mouse and human platelets revealed that activation of protein kinase A/G (PKA/PKG) not only inhibited thrombin/convulxin-induced platelet activation but also prevented the platelet pro-coagulant state. Here we investigated whether or not PKA/PKG activation could attenuate caspase-dependent apoptosis induced by the anti-cancer drugs ABT-737 (the precursor of navitoclax) and thymoquinone (TQ), thereby potentially limiting chemotherapy-induced thrombocytopenia...
June 29, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28659794/thymoquinone-as-a-potential-adjuvant-therapy-for-cancer-treatment-evidence-from-preclinical-studies
#18
REVIEW
A G M Mostofa, Md Kamal Hossain, Debasish Basak, Muhammad Shahdaat Bin Sayeed
Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumor cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28606050/insights-into-the-targeting-potential-of-thymoquinone-for-therapeutic-intervention-against-triple-negative-breast-cancer
#19
Md Abul Barkat, Harshita Abul, Javed Ahmad, Mohammad Ahmed Khan, Sarwar Beg, Farhan Jalees Ahmad
BACKGROUND: Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE: Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhances the efficacy and improve safety profile of clinically used anticancer drugs. METHOD: TQ acts on cell cycle and inhibits progression from G1 to S phase by targeting various proteins (cyclin D1, cyclin E, and p27)...
June 11, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28552110/antitumor-effect-of-thymoquinone-combined-with-resveratrol-on-mice-transplanted-with-breast-cancer
#20
Omar H Alobaedi, Wamidh H Talib, Iman A Basheti
OBJECTIVE: To test the anticancer potential activity of the combination of thymoquinone (TQ) and resveratrol (RES) against breast cancer in mice. METHODS: The antiproliferative activity of TQ, RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay. The combination index was calculated using isobolographic method. Balb/C mice were inoculated with EMT6/P cells and in vivo antitumor activity was evaluated...
April 2017: Asian Pacific Journal of Tropical Medicine
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