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Ellagic acid cancer

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https://www.readbyqxmd.com/read/28092161/estimation-of-ellagic-acid-and-or-repaglinide-effects-on-insulin-signaling-oxidative-stress-and-inflammatory-mediators-of-liver-pancreas-adipose-tissue-and-brain-in-insulin-resistant-type-2-diabetic-rats
#1
Mohamed M Amin, Mahmoud S Arbid
Even though ellagic acid has previously been valued in many models of cancer, so far its full mechanistic effect as a natural antiapoptotic agent in the prevention of type 2 diabetes complications has not been completely elucidated, which was the goal of this study. We fed albino rats a high-fat fructose diet (HFFD) for 2 months to induce insulin resistance/type 2 diabetes and then treated the rats with ellagic acid (10 mg/kg body weight, orally) and/or repaglinide (0.5 mg/kg body weight, orally) for 2 weeks...
October 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28017997/nutraceutical-properties-of-cumin-residue-generated-from-ayurvedic-industries-using-cell-line-models
#2
K B Arun, U Aswathi, V V Venugopal, T S Madhavankutty, P Nisha
Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe(2+) ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC50-238...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28004224/antioxidant-and-antiproliferative-effects-of-different-solvent-fractions-from-terminalia-belerica-roxb-fruit-on-various-cancer-cells
#3
Tapasree Basu, Sourav Panja, Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal
Terminalia belerica Roxb. fruits have been previously reported against diabetes, ulcer, microbial problems and hepatotoxicity. The present study was aimed to investigate antioxidant and anticancer potential of sequentially fractionated hexane (TBHE), chloroform (TBCE), ethyl acetate (TBEE), butanol (TBBE) and water (TBWE) extracts from the 70% methanolic extract of T. belerica fruits. TBCE, TBEE, TBBE and TBWE showed excellent ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging activities which was investigated using 11 different assays for various free radicals...
December 21, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27941714/inhibition-of-cervical-cancer-by-promoting-igfbp7-expression-using-ellagic-acid-from-pomegranate-peel
#4
Hongjun Guo, Dongya Zhang, Qingrui Fu
BACKGROUND The aim of this study was to explore the mechanism by which cervical cancer is inhibited by promoting IGFBP7 expression using ellagic acid from pomegranate peel extract. MATERIAL AND METHODS HeLa cells were divided into 6 groups: control group (NC), blank control group (BL), and IGFBP7 overexpression group (IGFBP7), and 2.5 uM, 5. 0 uM, and 10.0 uM ellagic acid-treated groups. The cell proliferation ability was detected and the degree of invasion in the 6 groups was measured by Transwell assay. The expression levels of IGFBP7 and AKT/mTOR in the 6 groups of cells were detected by RT-PCR technique...
December 12, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27879653/ellagic-acid-inhibits-bladder-cancer-invasiveness-and-in-vivo-tumor-growth
#5
Claudia Ceci, Lucio Tentori, Maria Grazia Atzori, Pedro M Lacal, Elena Bonanno, Manuel Scimeca, Rosella Cicconi, Maurizio Mattei, Maria Gabriella de Martino, Giuseppe Vespasiani, Roberto Miano, Grazia Graziani
Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. Previous studies have reported the antitumor properties of EA mainly using in vitro models. No data are available about EA influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular endothelial growth factor-A (VEGF-A), an angiogenic factor associated with disease progression and recurrence, and tumor growth in vivo...
November 22, 2016: Nutrients
https://www.readbyqxmd.com/read/27876336/inhibition-of-protein-glycation-antioxidant-and-antiproliferative-activities-of-carpobrotus-edulis-extracts
#6
Jawhar Hafsa, Khaoula Mkadmini Hammi, Med Raâfet Ben Khedher, Med Ali Smach, Bassem Charfeddine, Khalifa Limem, Hatem Majdoub
Carpobrotus edulis is an important South African medicinal plants used as a food and therapeutic agent in traditional medicine. The aim of this study was to determine the phytochemical content, antioxidant, antiglycation and cytotoxic effect against Human Colon Cancer Cell Line (HCT-116) of aqueous and ethanol-water (1:1v/v) extracts of Carpobrotus edulis.The content of total phenolics and flavonoids in aqueous and ethanol-water extract were 151.99μg and 66.35μg gallic acid equivalents/mg of dry extract, and 38...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27869910/the-methanol-ethyl-acetate-partitioned-fraction-from-chinese-olive-fruits-inhibits-cancer-cell-proliferation-and-tumor-growth-by-promoting-apoptosis-through-the-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Shu-Chen Hsieh, Wang-Ju Hsieh, An-Na Chiang, Nan-Wei Su, Yu-Te Yeh, Yi-Chun Liao
Chinese olives (Canarium album L.) have historically been used for medicinal purposes rather than commercially for oil. In this report, we reveal that the methanol-ethyl acetate partitioned fraction from Chinese olive fruits (MEO), of which ellagic acid accounted for 12%, exhibited profound anti-proliferative activities in the human colon cancer cell line, HCT116. Additionally, oral administration of MEO remarkably inhibited the tumor growth of subcutaneously implanted CT26 cells, a mouse colon carcinoma cell line, in BALB/c mice...
December 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27725205/methylated-urolithin-a-the-modified-ellagitannin-derived-metabolite-suppresses-cell-viability-of-du145-human-prostate-cancer-cells-via-targeting-mir-21
#8
Benhong Zhou, Jing Wang, Guohua Zheng, Zhenpeng Qiu
Urolithins are bioactive ellagic acid-derived metabolites produced by human colonic microflora. Although previous studies have demonstrated the cytotoxicity of urolithins, the effect of urolithins on miRNAs is still unclear. In this study, the suppressing effects of methylated urolithin A (mUA) on cell viability in human prostate cancer DU145 cells was investigated. mUA induced caspase-dependent cell apoptosis, mitochondrial depolarization and down-regulation of Bcl-2/Bax ratio. The results showed that upon exposure to mUA, miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27671231/sanguisorba-officinalis-l-synergistically-enhanced-5-fluorouracil-cytotoxicity-in-colorectal-cancer-cells-by-promoting-a-reactive-oxygen-species-mediated-mitochondria-caspase-dependent-apoptotic-pathway
#9
Meng-Ping Liu, Min Liao, Cong Dai, Jie-Feng Chen, Chun-Juan Yang, Ming Liu, Zuan-Guang Chen, Mei-Cun Yao
Sanguisorba officinalis L. radix is a widely used herb called DiYu (DY) in China and has an extensive range of bioactivities, including anti-cancer, anti-inflammatory, and anti-oxidative activities. However, there is little evidence to support its anti-cancer effects against colorectal cancer (CRC). The first-line chemotherapeutic agent 5-fluorouracil (5-FU) is used to treat CRC, but its efficiency is hampered by acquired drug resistance. This study found that a water extract of DY exerted anti-proliferative effects against two CRC cell lines (HCT-116 and RKO), and it sensitized CRC cells to 5-FU therapy by activating a reactive oxygen species (ROS)-mediated, mitochondria-caspase-dependent apoptotic pathway...
September 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27633111/improvements-in-metabolic-health-with-consumption-of-ellagic-acid-and-subsequent-conversion-into-urolithins-evidence-and-mechanisms
#10
REVIEW
Inhae Kang, Teresa Buckner, Neil F Shay, Liwei Gu, Soonkyu Chung
Ellagic acid (EA) is a naturally occurring polyphenol found in some fruits and nuts, including berries, pomegranates, grapes, and walnuts. EA has been investigated extensively because of its antiproliferative action in some cancers, along with its anti-inflammatory effects. A growing body of evidence suggests that the intake of EA is effective in attenuating obesity and ameliorating obesity-mediated metabolic complications, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27618150/a-phenolic-extract-obtained-from-methyl-jasmonate-treated-strawberries-enhances-apoptosis-in-a-human-cervical-cancer-cell-line
#11
Carmela Spagnuolo, Gema Flores, Gian Luigi Russo, Maria Luisa Ruiz Del Castillo
In the present study, we evaluated the effect of methyl jasmonate (MeJA) treatment on strawberry phenolic composition. Strawberry extracts contain a mixture of phenolic compounds possessing several biological properties. We demonstrated that these extracts were more effective in inducing apoptosis in HeLa cells compared to phenolic preparations derived from untreated strawberries. Treatment of strawberries with 0.5% MeJA resulted in increased polyphenols content (from 7.4 to 8.6 mM quercetin equivalents) and antioxidant properties (from 3...
October 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27506341/a-novel-photoelectrochemical-biosensor-for-protein-kinase-activity-assay-based-on-phosphorylated-graphite-like-carbon-nitride
#12
Xue Li, Yunlei Zhou, Yan Xu, Huijie Xu, Minghui Wang, Huanshun Yin, Shiyun Ai
Protein kinases are general and significant regulators in the cell signaling pathway, and it is still greatly desired to achieve simple and quick kinase detection. Herein, we develop a simple and sensitive photoelectrochemical strategy for the detection of protein kinase activity based on the bond between phosphorylated peptide and phosphorylated graphite-like carbon nitride (P-g-C3N4) conjugates triggered by Zr(4+) ion coordination. Under optimal conditions, the increased photocurrent is proportional to the protein kinase A (PKA) concentration ranging from 0...
August 31, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27478793/anti-inflammatory-and-antioxidant-activity-of-acalypha-hispida-leaf-and-analysis-of-its-major-bioactive-polyphenols-by-hplc
#13
Md Afjalus Siraj, Jamil A Shilpi, Md Golam Hossain, Shaikh Jamal Uddin, Md Khirul Islam, Ismet Ara Jahan, Hemayet Hossain
PURPOSE: Inflammation and oxidative stress can lead to different chronic diseases including cancer and atherosclerosis. Many medicinal plants have the potential to show as anti-inflammatory activity. Present investigation was performed to investigate anti-inflammatory, antioxidant activity, and quantification of selected bioactive plant polyphenols of the ethanol (EAH) and aqueous (AAH) extracts of Acalypha hispida (Euphorbiaceae) leaves. METHODS: Anti-inflammatory activity was evaluated by carragenan and histamine induced rat paw edema models while antioxidant capacity was evaluated by DPPH free radical scavenging, Fe+2 chelating ability, reducing power, NO scavenging, total phenolic and total flavonoid content assay...
June 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27460082/the-anti-oncogenic-influence-of-ellagic-acid-on-colon-cancer-cells-in-leptin-enriched-microenvironment
#14
Amany I Yousef, Omar S El-Masry, Eman H Yassin
Ellagic acid (EA) has been proposed as a promising candidate for therapeutic use in colon cancer. Investigation of the effectiveness of EA in a leptin-enriched model might have been given a little interest. Here in, we investigated the anti-tumor effect of EA in the presence of leptin to reflect on therapeutic use of EA in obesity-linked colon cancer. Proven effective in leptin-enriched microenvironment, EA inhibited cell proliferation of HCT-116 and CaCo-2 cell lines, modulated cell cycle, translocated Bax to the mitochondrial fraction of cells, activated caspase-8, and reduced PCNA expression...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27455311/walnut-phenolic-extract-and-its-bioactive-compounds-suppress-colon-cancer-cell-growth-by-regulating-colon-cancer-stemness
#15
Jisoo Lee, Yoo-Sun Kim, JaeHwan Lee, Seung Chul Heo, Kook Lae Lee, Sang-Woon Choi, Yuri Kim
Walnut has been known for its health benefits, including anti-cardiovascular disease and anti-oxidative properties. However, there is limited evidence elucidating its effects on cancer stem cells (CSCs) which represent a small subset of cancer cells that provide resistance against chemotherapy. This study aimed to evaluate the anti-CSCs potential of walnut phenolic extract (WPE) and its bioactive compounds, including (+)-catechin, chlorogenic acid, ellagic acid, and gallic acid. In the present study, CD133⁺CD44⁺ cells were isolated from HCT116 cells using fluorescence-activated cell sorting (FACS) and then treated with WPE...
July 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27386358/a-systematic-determination-of-polyphenols-constituents-and-cytotoxic-ability-in-fruit-parts-of-pomegranates-derived-from-five-chinese-cultivars
#16
Rui Li, Xiang Gui Chen, Kun Jia, Zhen Ping Liu, Hai Yan Peng
Plant polyphenols derived from pomegranates are natural health-promoting components, and their bioactivities are well proved. However, the systematic studies of polyphenols constituents and cytotoxic ability in fruit parts of pomegranates derived from different Chinese cultivars have not been studied yet. In this report, a validated and sensitive HPLC-DAD method and fluorescence spectrophotometric method was established for quantitative analysis of four polyphenols and total phenolic content (TPC) in fruit parts of pomegranates (including peels, flesh, seeds, juices and leaves) derived from five Chinese cultivars, respectively...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27320046/emblica-officinalis-amla-a-review-for-its-phytochemistry-ethnomedicinal-uses-and-medicinal-potentials-with-respect-to-molecular-mechanisms
#17
REVIEW
Bhavesh C Variya, Anita K Bakrania, Snehal S Patel
Medicinal plants, having great elementary and therapeutic importance, are the gift to mankind to acquire healthy lifestyle. Emblica officinalis Gaertn. or Phyllanthus emblica Linn. (Euphorbeaceae), commonly known as Indian gooseberry or Amla, has superior value in entirely indigenous traditional system of medicine, including folklore Ayurveda, for medicinal and nutritional purposes to build up lost vitality and vigor. In this article, numerous phytochemicals isolated from E. officinalis and its ethnomedical and pharmacological potentials with molecular mechanisms are briefly deliberated and recapitulated...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27261574/curcumin-and-ellagic-acid-synergistically-induce-ros-generation-dna-damage-p53-accumulation-and-apoptosis-in-hela-cervical-carcinoma-cells
#18
Devbrat Kumar, Soumya Basu, Lucy Parija, Deeptimayee Rout, Sanjeet Manna, Jagneshwar Dandapat, Priya Ranjan Debata
Cervical cancer and precancerous lesions of the cervix continue to be a global health issue, and the medication for the treatment for chronic HPV infection so far has not been effective. Potential anticancer and anti HPV activities of two known phytochemicals, Curcumin and Ellagic acid were evaluated in HeLa cervical cancer cells. Curcumin is a natural compound found in the root of Curcuma longa plant and Ellagic acid a polyphenol found in fruits of strawberries, raspberries and walnuts. The combination of Curcumin and Ellagic acid at various concentrations showed better anticancer properties than either of the drug when used alone as evidenced by MTT assay...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27219259/coagulation-changes-following-combined-ablative-and-reconstructive-breast-surgery
#19
Casey J Allen, Charles A Karcutskie, Laura Zebib, Gerardo A Guarch, Mena M Hanna, Jonathan P Meizoso, Juliet J Ray, Morad Askari, Seth R Thaller, Kenneth G Proctor
BACKGROUND: This study assessed hemostatic function in cancer patients at high risk for venous thromboembolism. METHODS: Thirty-eight female patients (age, 53 ± 9 years) undergoing immediate postmastectomy reconstruction were prospectively studied with informed consent. Blood was sampled preoperatively, on postoperative day 1, and at 1 week follow-up. Rotational thromboelastography clotting time, α-angle (clot kinetics), clot formation time, and maximum clot firmness were studied with three different activating agents: intrinsically activated test using ellagic acid, extrinsically activated test with tissue factor, and fibrin-based extrinsically activated test with tissue factor and the platelet inhibitor cytochalasin D...
June 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27216246/evidence-supporting-the-conceptual-framework-of-cancer-chemoprevention-in-canines
#20
Tamara P Kondratyuk, Julie Ann Luiz Adrian, Brian Wright, Eun-Jung Park, Richard B van Breemen, Kenneth R Morris, John M Pezzuto
As with human beings, dogs suffer from the consequences of cancer. We investigated the potential of a formulation comprised of resveratrol, ellagic acid, genistein, curcumin and quercetin to modulate biomarkers indicative of disease prevention. Dog biscuits were evaluated for palatability and ability to deliver the chemopreventive agents. The extent of endogenous DNA damage in peripheral blood lymphocytes from dogs given the dietary supplement or placebo showed no change. However, H2O2-inducible DNA damage was significantly decreased after consumption of the supplement...
2016: Scientific Reports
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