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Ellagic acid cancer

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https://www.readbyqxmd.com/read/28718725/ellagic-acid-enhances-apoptotic-sensitivity-of-breast-cancer-cells-to-%C3%AE-radiation
#1
Vidhula Ahire, Amit Kumar, Kaushala Prasad Mishra, Gauri Kulkarni
Herbal polyphenols have gained increased significance because of the promises they hold in the prevention and treatment of cancer. There exists an enormous opportunity for the screening and valuation of natural dietary compounds in the development of an effective chemopreventive drug and radiosensitizer that may be of practical use for patients undergoing cancer therapy. This study describes the effect of the flavonoid ellagic acid (EA) on gamma-irradiated human breast cancer MCF-7 cells in vitro when administered alone or in combination with radiation...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28696100/thermosensitive-liposomal-codelivery-of-hsa-paclitaxel-and-hsa-ellagic-acid-complexes-for-enhanced-drug-perfusion-and-efficacy-against-pancreatic-cancer
#2
Yan Wei, Yuxi Wang, Dengning Xia, Shiyan Guo, Feng Wang, Xinxin Zhang, Yong Gan
Fibrotic stroma and tumor-promoting pancreatic stellate cells (PSCs), critical characters in the pancreatic ductal adenocarcinoma (PDA) microenvironment, promote a tumor-facilitating environment that simultaneously prevents drug penetration into tumor foci and stimulates tumor growth. Nab-PTX, a human serum albumin (HSA) nanoparticle of paclitaxel (PTX), indicates enhanced matrix penetration in PDA probably due to its small size in vivo and high affinity of HSA with secreted protein acidic and rich in cysteine (SPARC), overexpressed in the PDA stroma...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28631098/urolithins-impair-cell-proliferation-arrest-the-cell-cycle-and-induce-apoptosis-in-umuc3-bladder-cancer-cells
#3
Joana Liberal, Anália Carmo, Célia Gomes, Maria Teresa Cruz, Maria Teresa Batista
Ellagitannins have been gaining attention as potential anticancer molecules. However, the low bioavailability of ellagitannins and their extensive metabolization in the gastrointestinal tract into ellagic acid and urolithins suggest that the health benefits of consuming ellagitannins rely on the direct effects of their metabolites. Recently, chemopreventive and chemotherapeutic activities were ascribed to urolithins. Nonetheless, there is still a need to screen and evaluate the selectivity of these molecules and to elucidate their cellular mechanisms of action...
June 20, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28557449/antimalarial-activities-of-alkyl-cyclohexenone-derivatives-isolated-from-the-leaves-of-poupartia-borbonica
#4
Allison Ledoux, Alexis St-Gelais, Ewa Cieckiewicz, Olivia Jansen, Annélise Bordignon, Bertrand Illien, Nicolas Di Giovanni, Arnaud Marvilliers, Floriane Hoareau, Hélène Pendeville, Joëlle Quetin-Leclercq, Michel Frédérich
Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1-3, and named Poupartone A-C. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data analysis and MS, whereas calculated and experimental ECD spectra were used to define the absolute configurations. These compounds were active against 3D7 and W2 Plasmodium falciparum strains with IC50 values between 0.55 and 1.81 μM...
May 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28521254/cs-peg-decorated-plga-nano-prototype-for-delivery-of-bioactive-compounds-a-novel-approach-for-induction-of-apoptosis-in-hepg2-cell-line
#5
Ahmed A Abd-Rabou, Hanaa H Ahmed
PURPOSE: Polymer-based nanoparticles are used as vectors for cancer drug delivery. The bioactive compounds (quercetin, ellagic acid and gallic acid) are well known to be not only antioxidants but also chemopreventive candidates against various types of cancers. To circumvent the low bioavailability and the short half-life time obstacles, we hypothesized a novel PLGA nano-platform functionalized with CS and PEG to encapsulate these phytochemicals. This encapsulation will protect the compounds from the phagocytic uptake and deliver PLGA-CS-PEG nano-prototype with high biodegradability and biosafety...
March 12, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28476711/new-ellagic-acid-derivative-from-the-fruits-of-heat-tolerant-plant-conocarpus-lancifolius-engl-and-their-anti-inflammatory-cytotoxic-ppar-agonistic-activities
#6
Areej Mohammad Al-Taweel, Shagufta Perveen, Ghada Ahmed Fawzy, Rashad Mehmood, Afsar Khan, Shabana Iqrar Khan
Conocarpus lancifolius (Combretaceae), is distributed in Riyadh, Saudi Arabia. It is a heat-tolerant Saudi medicinal plant, demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against MRC-5 cancer cell line, as well as prominent antiprotozoal and antibacterial activities. The objective of this study is to isolate the compounds and evaluate the anti-inflammatory, cytotoxic, PPAR agonistic and antioxidant activities of extracts and pure constituents from C. lancifolius...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28467979/negative-effect-of-ellagic-acid-on-cytosolic-ph-regulation-and-glycolytic-flux-in-human-endometrial-cancer-cells
#7
Khalid N M Abdelazeem, Yogesh Singh, Florian Lang, Madhuri S Salker
BACKGROUND/AIMS: Key properties of tumor cells include enhanced glycolytic flux with excessive consumption of glucose and formation of lactate. As glycolysis is highly sensitive to cytosolic pH, maintenance of glycolysis requires export of H+ ions, which is in part accomplished by Na+/H+ exchangers, such as NHE1. The carrier is sensitive to oxidative stress. Growth of tumor cells could be suppressed by the polyphenol Ellagic acid, which is found in various fruits and vegetables. An effect of Ellagic acid on transport processes has, however, never been reported...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28462130/water-extract-of-galla-rhois-with-steaming-process-enhances-apoptotic-cell-death-in-human-colon-cancer-cells
#8
Nam-Hui Yim, Min Jung Gu, Youn-Hwan Hwang, Won-Kyung Cho, Jin Yeul Ma
BACKGROUND: Galla Rhois has been considered to have medicinal properties against diarrhea, excessive sweating, bleeding, and chronic cough in Asian countries. Gallotannins, which are Galla Rhois-derived tannins, have been reported to possess biological and pharmacological activities, especially anticancer activity. In this study, we evaluated the effect of steaming at a temperature over 120 °C on the chemical constituents and biological activities of the water extract of Galla Rhois (GRE)...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28329437/phenolic-fractions-from-muscadine-grape-noble-pomace-can-inhibit-breast-cancer-cell-mda-mb-231-better-than-those-from-european-grape-cabernet-sauvignon-and-induce-s-phase-arrest-and-apoptosis
#9
Jianming Luo, Zheng Wei, Shengyu Zhang, Xichun Peng, Yu Huang, Yali Zhang, Jiang Lu
Tons of grape pomace which still contained a rich amount of plant polyphenols, is discarded after winemaking. Plant polyphenols have multi-functional activities for human body. In this study, polyphenols of pomaces from Muscadinia rotundifolia "Noble" and Vitis vinifera "Cabernet Sauvignon" were extracted and fractionated, and then they were analyzed with LC-MS and the inhibitory effects on breast cancer cells were compared. The inhibition on MDA-MB-231 cells of fractions from "Noble" was further evaluated...
May 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28207992/inhibitory-activities-of-butanol-fraction-from-butea-monosperma-lam-taub-bark-against-free-radicals-genotoxins-and-cancer-cells
#10
Varinder Kaur, Manish Kumar, Paramjeet Kaur, Sandeep Kaur, Satwinderjeet Kaur
The present study was undertaken to investigate antioxidant, antigenotoxic, and antiproliferative activity of butanol fraction (Bmbu) from bark of medicinal plant Butea monosperma. Antioxidant potency of Bmbu was examined by various in vitro assays. It was also investigated for antigenotoxic activity using Escherichia coli. PQ37 employing SOS chromotest. Further, cytotoxic and apoptosis inducing activity of Bmbu was evaluated in MCF-7 breast cancer cells. Bmbu showed potent free radical scavenging ability in ABTS assay (IC50 56...
February 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28183047/gene-expression-changes-in-colon-tissues-from-colorectal-cancer-patients-following-the-intake-of-an-ellagitannin-containing-pomegranate-extract-a-randomized-clinical-trial
#11
María A Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, Noelia V García-Talavera, María B Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M García-Albert, Francisco J Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A Pastor-Quirante, Francisco Martínez-Díaz, Francisco A Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa
The clinical evidence of dietary polyphenols as colorectal cancer (CRC) chemopreventive compounds is very weak. Verification in humans of tissue-specific molecular regulation by the intake of polyphenols requires complex clinical trials that allow for the procurement of sufficient pre- and postsupplementation tissue samples. Ellagitannins (ETs), ellagic acid (EA) and their gut microbiota-derived metabolites, the urolithins, modify gene expression in colon normal and cancer cultured cells. We conducted here the first clinical trial with 35 CRC patients daily supplemented with 900 mg of an ET-containing pomegranate extract (PE) and evaluated the expression of various CRC-related genes in normal and cancerous colon tissues before (biopsies) and after (surgical specimens) 5-35 days of supplementation...
January 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28169238/evaluating-the-effects-of-ellagic-acid-on-pstat3-pakt-and-perk1-2-signaling-pathways-in-prostate-cancer-pc3-cells
#12
Elaheh Eskandari, Esfandiar Heidarian, Sayed Asadollah Amini, Javad Saffari-Chaleshtori
OBJECTIVE: One of the most common malignancies among men is prostate cancer. Ellagic acid (EA), a polyphenol antioxidant, has many pharmacological actions, especially anticancer effects. The purpose of this study was to evaluate the effect of EA treatment on interleukin-6 (IL-6) gene expression, cell viability, IL-6 secretion, phosphorylated STAT3, ERK, and AKT cellular signaling proteins in human prostate cancer cells (PC3). MATERIALS AND METHODS: The cytotoxic effects of the EA (0-100 µM) on PC3 cells were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28135203/ellagic-acid-inhibits-the-proliferation-of-human-pancreatic-carcinoma-panc-1-cells-in-vitro-and-in-vivo
#13
Hao Cheng, Chenglin Lu, Ribo Tang, Yiming Pan, Shanhua Bao, Yudong Qiu, Min Xie
Ellagic aicd (EA), a dietary polyphenolic compound found in plants and fruits, possesses various pharmacological activities. This study investigated the effect of EA on human pancreatic carcinoma PANC-1 cells both in vitro and in vivo; and defined the associated molecular mechanisms. In vitro, the cell growth and repairing ability were assessed by CCK-8 assay and wound healing assay. The cell migration and invasion activity was evaluated by Tanswell assay. In vivo, PANC-1 cell tumor-bearing mice were treated with different concentrations of EA...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28122160/physicochemical-properties-antioxidant-and-anti-proliferative-capacities-of-dried-leaf-and-its-extract-from-xao-tam-phan-paramignya-trimera
#14
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (Paramignya trimera) has been used for the treatment of cancer and cancer-like aliments. Among different parts of the P. trimera plant, leaf is considered as a residual part after harvesting of the root. This study aimed to determine the physiochemical properties and the antioxidant and anti-proliferative capacities of P. trimera leaf (PTL) using microwave drying for the preparation of dry sample; MeOH and microwave-assisted extraction for the preparation of crude extract; and freeze-drying for the preparation of powdered extract...
January 25, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28101576/multiple-effects-of-ellagic-acid-on-human-colorectal-carcinoma-cells-identified-by-gene-expression-profile-analysis
#15
Jinlu Zhao, Guodong Li, Wanlan Bo, Yuhui Zhou, Shuwei Dang, Jiufeng Wei, Xinglong Li, Ming Liu
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer in the world. Phytochemicals have become a research hotspot in recent years as cancer prevention and treatment agents due to their low toxicity and limited side-effects. Ellagic acid (EA), a natural phenolic constituent, displays various biological activities, including anticancer effects. However, the detailed anticancer mechanisms of EA remain unclear. In the present study, we found that EA inhibited the growth of HCT-116 colon cancer cells...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28092161/estimation-of-ellagic-acid-and-or-repaglinide-effects-on-insulin-signaling-oxidative-stress-and-inflammatory-mediators-of-liver-pancreas-adipose-tissue-and-brain-in-insulin-resistant-type-2-diabetic-rats
#16
COMPARATIVE STUDY
Mohamed M Amin, Mahmoud S Arbid
Even though ellagic acid has previously been valued in many models of cancer, so far its full mechanistic effect as a natural antiapoptotic agent in the prevention of type 2 diabetes complications has not been completely elucidated, which was the goal of this study. We fed albino rats a high-fat fructose diet (HFFD) for 2 months to induce insulin resistance/type 2 diabetes and then treated the rats with ellagic acid (10 mg/kg body weight, orally) and/or repaglinide (0.5 mg/kg body weight, orally) for 2 weeks...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28017997/nutraceutical-properties-of-cumin-residue-generated-from-ayurvedic-industries-using-cell-line-models
#17
K B Arun, U Aswathi, V V Venugopal, T S Madhavankutty, P Nisha
Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe(2+) ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC50-238...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28004224/antioxidant-and-antiproliferative-effects-of-different-solvent-fractions-from-terminalia-belerica-roxb-fruit-on-various-cancer-cells
#18
Tapasree Basu, Sourav Panja, Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal
Terminalia belerica Roxb. fruits have been previously reported against diabetes, ulcer, microbial problems and hepatotoxicity. The present study was aimed to investigate antioxidant and anticancer potential of sequentially fractionated hexane (TBHE), chloroform (TBCE), ethyl acetate (TBEE), butanol (TBBE) and water (TBWE) extracts from the 70% methanolic extract of T. belerica fruits. TBCE, TBEE, TBBE and TBWE showed excellent ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging activities which was investigated using 11 different assays for various free radicals...
April 2017: Cytotechnology
https://www.readbyqxmd.com/read/27941714/inhibition-of-cervical-cancer-by-promoting-igfbp7-expression-using-ellagic-acid-from-pomegranate-peel
#19
Hongjun Guo, Dongya Zhang, Qingrui Fu
BACKGROUND The aim of this study was to explore the mechanism by which cervical cancer is inhibited by promoting IGFBP7 expression using ellagic acid from pomegranate peel extract. MATERIAL AND METHODS HeLa cells were divided into 6 groups: control group (NC), blank control group (BL), and IGFBP7 overexpression group (IGFBP7), and 2.5 uM, 5. 0 uM, and 10.0 uM ellagic acid-treated groups. The cell proliferation ability was detected and the degree of invasion in the 6 groups was measured by Transwell assay. The expression levels of IGFBP7 and AKT/mTOR in the 6 groups of cells were detected by RT-PCR technique...
December 12, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27879653/ellagic-acid-inhibits-bladder-cancer-invasiveness-and-in-vivo-tumor-growth
#20
Claudia Ceci, Lucio Tentori, Maria Grazia Atzori, Pedro M Lacal, Elena Bonanno, Manuel Scimeca, Rosella Cicconi, Maurizio Mattei, Maria Gabriella de Martino, Giuseppe Vespasiani, Roberto Miano, Grazia Graziani
Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. Previous studies have reported the antitumor properties of EA mainly using in vitro models. No data are available about EA influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular endothelial growth factor-A (VEGF-A), an angiogenic factor associated with disease progression and recurrence, and tumor growth in vivo...
November 22, 2016: Nutrients
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