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Ellagic acid cancer

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https://www.readbyqxmd.com/read/29725861/ellagic-acid-sulforaphane-and-ursolic-acid-in-the-prevention-and-therapy-of-breast-cancer-current-evidence-and-future-perspectives
#1
REVIEW
Md Sadikuj Jaman, Md Abu Sayeed
Globally, breast cancer is the most common cancer and the second leading cause of cancer-related death among women. Surgery, chemotherapy, hormonal therapy, and radiotherapy are currently available treatment options for breast cancer therapy. However, chemotherapy, hormonal therapy, and radiotherapy are often associated with side effects and multidrug resistance, recurrence, and lack of treatment in metastasis are the major problems in the treatment of breast cancer. Recently, dietary phytochemicals have emerged as advantageous agents for the prevention and therapy of cancer due to their safe nature...
May 3, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29465116/polyphenols-rich-extract-from-pleurotus-eryngii-with-growth-inhibitory-of-hct116-colon-cancer-cells-and-anti-inflammatory-function-in-raw264-7-cells
#2
Qiuhui Hu, Biao Yuan, Hang Xiao, Liyan Zhao, Xian Wu, Kanyasiri Rakariyatham, Lei Zhong, Yanhui Han, Benard Muinde Kimatu, Wenjian Yang
Edible mushrooms are rich sources of bioactive components. In this study, a polyphenol-rich extract, designated as PPEP, was isolated from an edible mushroom, Pleurotus eryngii. Using ultra high performance liquid chromatograph combined with triple time-of-flight mass spectrometry (UPLC-TOF/MS/MS), gallic acid monohydrate, 3-(3,4-dihydroxyphenyl)-propionic acid, methyl gallate, syringic acid, ellagic acid and catechin were identified in PPEP. This phenolic-rich extract PPEP exhibited anti-inflammatory effect in lipopolysaccharide-stimulated RAW264...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29423599/establishment-of-pressurized-liquid-extraction-by-response-surface-methodology-approach-coupled-to-hplc-dad-tof-ms-for-the-determination-of-phenolic-compounds-of-myrtle-leaves
#3
Elixabet Díaz-de-Cerio, David Arráez-Román, Antonio Segura-Carretero, Pasquale Ferranti, Rosario Nicoletti, Giuseppe Mirko Perrotta, Ana María Gómez-Caravaca
Myrtus communis L. (myrtle) is native to the Mediterranean region and Western Asia. Its leaves have demonstrated its potential effect towards different bioactivities like anti-diabetic, anti-diarrheic, anti-ulcer, anti-cancer, among others. These activities have been associated with its phenolic content. In this sense, the aim of this work has been to develop a new pressurized-liquid extraction procedure (PLE), by using a response surface methodology (RSM), to evaluate the phenolic composition from myrtle leaves by HPLC-DAD-TOF-MS...
February 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29407582/nm23-downregulation-and-lysophosphatidic-acid-receptor-edg2-lpa1-upregulation-during-myeloid-differentiation-of-human-leukemia-cells
#4
Junko Okabe-Kado, Yuki Hagiwara-Watanabe, Nozomi Niitsu, Takashi Kasukabe, Yasuhiko Kaneko
The NM23 gene is overexpressed in many hematological malignancies and its overexpression predicts poor treatment outcomes. NM23 overexpression is thought to suppress myeloid differentiation of leukemia cells, but the molecular mechanism is unknown. In breast cancer cells, the lysophosphatidic acid (LPA) receptor EDG2/lpa1 was downregulated by NM23-H1 overexpression, and this reciprocal expression pattern was associated with suppressed or induced cell motility/metastasis. Here, we examined the relationship between EDG2 and NM23 expression during myeloid differentiation of leukemia cells...
March 2018: Leukemia Research
https://www.readbyqxmd.com/read/29300453/novel-metal-polyphenol-framework-for-mr-imaging-guided-photothermal-therapy
#5
Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Haibao Wang, Zhen Guo, Qianwang Chen
Phothermal therapy has received increasing attention in recent years as a potentially effective way to treat cancer. In pursuit of a more biocompatible photothermal agent, we utilize biosafe materials including ellagic acid (EA), polyvinylpyrrolidone (PVP), and iron element as building blocks, and we successfully fabricate a homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nanoagent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo...
January 31, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29249924/the-comparative-study-among-different-fractions-of-muscadine-grape-noble-pomace-extracts-regarding-anti-oxidative-activities-cell-cycle-arrest-and-apoptosis-in-breast-cancer
#6
Jianming Luo, Shiren Song, Zheng Wei, Yu Huang, Yali Zhang, Jiang Lu
As a by-product of wine making, pomace contains rich amounts of phenolic compounds that can be potentially utilized as raw materials to make beneficial products especially for the anti-cancer agents including the breast cancer. Muscadinia rotundifolia 'Noble' is a wine-making grape cultivar, and to better use 'Noble' pomace, the most effective phenolic fractions in cancer inhibition must be identified. In this study, anti-oxidative activities of three separated fractions of 'Noble' pomace (F1, F2 and F3) were compared in 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging (DPPH and ABTS) assays as well as the ferric-reducing antioxidant power (FRAP) assay...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29244711/flavonoids-and-ellagitannins-characterization-antioxidant-and-cytotoxic-activities-of-phyllanthus-acuminatus-vahl
#7
Mirtha Navarro, Ileana Moreira, Elizabeth Arnaez, Silvia Quesada, Gabriela Azofeifa, Felipe Vargas, Diego Alvarado, Pei Chen
The phenolic composition of leaves from Phyllanthus acuminatus L., a plant commonly used in Costa Rica as traditional medicine, was studied using UPLC-ESI-MS on an enriched phenolic extract. A total of 20 phenolic compounds were identified, comprising eight flavonoids (two flavanones-pinocembrin isomers and six derivatives from apigenin, chrysin, quercetin, and kaempferol); seven ellagitannins, two flavan-3-ols (prodelphinidin B dimer and (epi)gallocatechin); and three phenolic acids (ellagic acid, trimethylellagic acid, and ferulic acid)...
December 15, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29200719/anti-cancer-effects-of-polyphenolic-compounds-in-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-resistant-non-small-cell-lung-cancer
#8
Hyungmin Jeong, Ai N H Phan, Jong-Whan Choi
Background: Polyphenolic phytochemicals are natural compounds, easily found in fruits and vegetables. Importantly, polyphenols have been intensively studied as excellent antioxidant activity which contributes to anticancer function of the natural compounds. Lung cancer has been reported to mainly account for cancer-related deaths in the world. Moreover, epidermal growth factor receptor tyrosine kinase inhibitor (TKI) resistance is one of the biggest issues in cancer treatment, especially in nonsmall cell lung cancer (NSCLC)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29197410/direct-inhibition-of-actn4-by-ellagic-acid-limits-breast-cancer-metastasis-via-regulation-of-%C3%AE-catenin-stabilization-in-cancer-stem-cells
#9
Neng Wang, Qi Wang, Hailin Tang, Fengxue Zhang, Yifeng Zheng, Shengqi Wang, Jin Zhang, Zhiyu Wang, Xiaoming Xie
BACKGROUND: Pharmacology-based target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. Ellagic acid (EA), a dietary polyphenol compound, exhibits potent anticancer activities; however, the underlying mechanisms remain unclear. The current study sought to determine the role and regulation of ACTN4 expression in human breast cancer metastasis and EA-based therapy. METHODS: The anti-metastasis ability of EA was validated by MMTV-PyMT mice and in vitro cell models...
December 2, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29173024/main-components-of-pomegranate-ellagic-acid-and-luteolin-inhibit-metastasis-of-ovarian-cancer-by-down-regulating-mmp2-and-mmp9
#10
Huidi Liu, Zheng Zeng, Siwen Wang, Ting Li, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Yongfang Liu, Wei Liu, Sijing Hu, Shan Gao, Miao Yu, Yingying Qi, Zhihang Shen, Hongyue Wang, Tingting Gao, Lingqin Dong, Randal N Johnston, Shu-Lin Liu
Ovarian cancer is the third most common cancer in the female reproductive organs and epithelial ovarian cancer has the highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) has been shown to inhibit the growth of several types of cancer other than ovarian cancer. In this study, we exposed the ovarian cancer cell line A2780 to PFJ and two of its components (ellagic acid and luteolin). MTT and wound healing assays demonstrated that all three treatments suppressed the proliferation and migration of the ovarian cancer cells...
December 2, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29141541/ellagic-acid-a-logical-lead-for-drug-development
#11
Abolfazl Shakeri, Mohammad Reza Zirak, Amirhossein Sahebkar
BACKGROUND: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. METHODS: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29109723/inhibition-of-pro-inflammatory-and-anti-apoptotic-biomarkers-during-experimental-oral-cancer-chemoprevention-by-dietary-black-raspberries
#12
Steve Oghumu, Bruce C Casto, Jennifer Ahn-Jarvis, Logan C Weghorst, Jim Maloney, Paul Geuy, Kyle Z Horvath, Claire E Bollinger, Blake M Warner, Kurt F Summersgill, Christopher M Weghorst, Thomas J Knobloch
Oral cancer continues to be a significant public health problem worldwide. Recently conducted clinical trials demonstrate the ability of black raspberries (BRBs) to modulate biomarkers of molecular efficacy that supports a chemopreventive strategy against oral cancer. However, it is essential that a preclinical animal model of black raspberry (BRB) chemoprevention which recapitulates human oral carcinogenesis be developed, so that we can validate biomarkers and evaluate potential mechanisms of action. We therefore established the ability of BRBs to inhibit oral lesion formation in a carcinogen-induced rat oral cancer model and examined potential mechanisms...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29103827/hybrid-drug-combination-anti-diabetic-treatment-of-type-2-diabetic-wistar-rats-with-combination-of-ellagic-acid-and-pioglitazone
#13
Rakesh P Nankar, Mukesh Doble
BACKGROUND: Pioglitazone is an effective drug for the treatment of type 2 diabetes. The drug was suspended from Indian market in June 2013 due to the risk of bladder cancer but was reintroduced in July 2013 because its benefits outweighed the risks. The risks associated with pioglitazone can be minimized if its dose is reduced. HYPOTHESIS: Ellagic acid, a polyphenolic antioxidant, is reported to reduce blood sugar in diabetic rats. The mechanism of anti-diabetic action of ellagic acid is not known...
December 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29070894/radiosensitizing-effect-of-ellagic-acid-on-growth-of-hepatocellular-carcinoma-cells-an-in-vitro-study
#14
Ujjal Das, Sushobhan Biswas, Sreya Chattopadhyay, Anindita Chakraborty, Rakhi Dey Sharma, Asoke Banerji, Sanjit Dey
Failure of treatment for cancer in clinic by radio/chemotherapy is generally attributed to tumour resistance. Therefore, it is important to develop strategies to increase the cytotoxicity of tumour cells by radiation in combination with unique tumour selective cytotoxic agents. We evaluated the potential of ellagic acid (EA) as an enhancer of oxidative stress in cancer cells. HepG2 cells were treated with EA (10 µM) for 12 h prior to exposure of single 7.5 Gy dose of irradiation. Treatment of HepG2 cells with EA and gamma radiation showed increased reactive oxygen species generation, up regulation of p53 protein expression, decreased survival markers level like p-Akt, p-NF-kB and p-STAT3 which were significantly higher after radiation treatment alone...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066891/enhanced-anticancer-activity-and-oral-bioavailability-of-ellagic-acid-through-encapsulation-in-biodegradable-polymeric-nanoparticles
#15
Fatma M Mady, Mohamed A Shaker
Despite the fact that various studies have investigated the clinical relevance of ellagic acid (EA) as a naturally existing bioactive substance in cancer therapy, little has been reported regarding the efficient strategy for improving its oral bioavailability. In this study, we report the formulation of EA-loaded nanoparticles (EA-NPs) to find a way to enhance its bioactivity as well as bioavailability after oral administration. Poly(ε-caprolactone) (PCL) was selected as the biodegradable polymer for the formulation of EA-NPs through the emulsion-diffusion-evaporation technique...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28992990/one-step-targeted-accumulation-and-detection-of-camptothecin-analogues-from-fruits-of-camptotheca-acuminata-decne-using-bilayer-solid-phase-extraction-coupled-with-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#16
Menghan Chen, Yi Li, Deran Xu, Jun Luo, Lingyi Kong
Camptothecins, a kind of monoterpene-quinoline alkaloids from Camptotheca acuminata Decne, have long attracted much attention worldwide as an anti-cancer drug. However, there is still a lack of effective methods for the accumulation and discovery of camptothecin analogues from botanic resources for camptothecin-based drug research. This work develops a one-step method for the targeted accumulation, quick detection, and identification of camptothecin analogues from C. acuminata fruit using bilayer solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (bilayer-SPE-UHPLC-Q-TOF-MS/MS)...
November 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28979765/micrornas-in-the-development-and-neoplasia-of-the-mammary-gland
#17
REVIEW
Manoj Kumar Jena
Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation...
2017: F1000Research
https://www.readbyqxmd.com/read/28932378/benefits-of-ellagic-acid-from-grapes-and-pomegranates-against-colorectal-cancer
#18
Sayedalireza Mirsane, Sayedmojtaba Mirsane
No abstract text is available yet for this article.
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28855870/leaf-and-root-extracts-from-campomanesia-adamantium-myrtaceae-promote-apoptotic-death-of-leukemic-cells-via-activation-of-intracellular-calcium-and-caspase-3
#19
Jaqueline F Campos, Priscilla P de Toledo Espindola, Heron F V Torquato, Wagner D Vital, Giselle Z Justo, Denise B Silva, Carlos A Carollo, Kely de Picoli Souza, Edgar J Paredes-Gamero, Edson L Dos Santos
Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer potential of this plant species, the aim of this study was to evaluate the antileukemic activity and the chemical composition of aqueous extracts from the leaves (AECL) and roots (AECR) of C. adamantium and their possible mechanisms of action...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28841784/regulation-of-microrna-using-promising-dietary-phytochemicals-possible-preventive-and-treatment-option-of-malignant-mesothelioma
#20
REVIEW
Md Abu Sayeed, Massimo Bracci, Guendalina Lucarini, Raffaella Lazzarini, Roberto Di Primio, Lory Santarelli
Malignant mesothelioma (MM) is a very aggressive, lethal cancer, and its incidence is increasing worldwide. Development of multi-drug resistance, therapy related side-effects, and disease recurrence after therapy are the major problems for the successful treatment of MM. Emerging evidence indicates that dietary phytochemicals can exert anti-cancer activities by regulating microRNA expression. Until now, only one dietary phytochemical (ursolic acid) has been reported to have MM microRNA regulatory ability. A large number of dietary phytochemicals still remain to be tested...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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