keyword
MENU ▼
Read by QxMD icon Read
search

Ciclesonide

keyword
https://www.readbyqxmd.com/read/28356782/an-evaluation-of-exact-matching-and-propensity-score-methods-as-applied-in-a-comparative-effectiveness-study-of-inhaled-corticosteroids-in-asthma
#1
Anne Burden, Nicolas Roche, Cristiana Miglio, Elizabeth V Hillyer, Dirkje S Postma, Ron Mc Herings, Jetty A Overbeek, Javaria Mona Khalid, Daniela van Eickels, David B Price
BACKGROUND: Cohort matching and regression modeling are used in observational studies to control for confounding factors when estimating treatment effects. Our objective was to evaluate exact matching and propensity score methods by applying them in a 1-year pre-post historical database study to investigate asthma-related outcomes by treatment. METHODS: We drew on longitudinal medical record data in the PHARMO database for asthma patients prescribed the treatments to be compared (ciclesonide and fine-particle inhaled corticosteroid [ICS])...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28334528/why-prodrugs-and-propesticides-succeed
#2
John E Casida
What are the advantages of bioactivation in optimizing drugs and pesticides? Why are there so many prodrugs and propesticides? These questions are examined here by considering compounds selected on the basis of economic value or market success. The 100 major drugs and 90 major pesticides are divided into ones acting directly and those definitely or possibly requiring bioactivation. Established or candidate prodrugs accounted for 19% of the total drug sales with corresponding values of 20, 37 and 17% for proinsecticides, proherbicides and profungicides...
March 23, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28331346/control-of-moderate-to-severe-asthma-with-randomized-ciclesonide-doses-of-160-320-and-640-%C3%AE-g-day
#3
Søren E Pedersen, Niyati Prasad, Udo-Michael Goehring, Henrik Andersson, Dirkje S Postma
BACKGROUND: The inhaled corticoteroid (ICS) ciclesonide (Cic), controls asthma symptoms in the majority of patients at the recommended dose of 160 µg/day. However, the relationship between the level of asthma control and increasing doses of Cic is unknown. This study investigated whether long-term treatment with higher doses of Cic would further improve asthma symptoms in patients with uncontrolled asthma despite ICS use. PATIENTS AND METHODS: In a double-blind, randomized, parallel-group study, 367 patients were allocated to one of three treatment arms (Cic 160, 320 and 640 µg/day)...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28159683/measurement-of-the-raman-spectra-and-hygroscopicity-of-four-pharmaceutical-aerosols-as-they-travel-from-pressurised-metered-dose-inhalers-pmdi-to-a-model-lung
#4
N Davidson, H-J Tong, M Kalberer, P C Seville, A D Ward, M K Kuimova, F D Pope
Particle inhalation is an effective and rapid delivery method for a variety of pharmaceuticals, particularly bronchodilation drugs used for treating asthma and COPD. Conditions of relative humidity and temperature inside the lungs are generally very different from the outside ambient air, with the lung typically being warmer and more humid. Changes in humidity, from inhaler to lung, can cause hygroscopic phase transitions and particle growth. Increasing particle size and mass can negatively affect particle deposition within the lung leading to inefficient treatment, while deliquescence prior to impaction is liable to accelerate drug uptake...
January 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28144080/a-randomized-double-blind-study-comparing-the-efficacy-and-safety-of-a-combination-of-formoterol-and-ciclesonide-with-ciclesonide-alone-in-asthma-subjects-with-moderate-to-severe-airflow-limitation
#5
Madhu Sudan Barthwal, Shailesh Meshram
No abstract text is available yet for this article.
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28115915/effects-of-corticosteroid-plus-long-acting-beta2-agonist-on-the-expression-of-pd-l1-in-double-stranded-rna-induced-lung-inflammation-in-mice
#6
Saaka Hamano, Koichiro Matsumoto, Ken Tonai, Satoru Fukuyama, Keiko Kan-O, Nanae Seki, Hiromasa Inoue, Yoichi Nakanishi
BACKGROUND: Airway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of viruses from the host immune systems. This escape may be associated with the persistence of viral infection and the exacerbation of the underlying diseases. In a study in vitro, we have shown that corticosteroids plus long-acting beta2-agonists (LABAs) attenuate the upregulation of PD-L1 on airway epithelial cells stimulated with an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly I:C)...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28102056/asthma-related-outcomes-in-patients-initiating-extrafine-ciclesonide-or-fine-particle-inhaled-corticosteroids
#7
Dirkje S Postma, Richard Dekhuijzen, Thys van der Molen, Richard J Martin, Wim van Aalderen, Nicolas Roche, Theresa W Guilbert, Elliot Israel, Daniela van Eickels, Javaria Mona Khalid, Ron M C Herings, Jetty A Overbeek, Cristiana Miglio, Victoria Thomas, Catherine Hutton, Elizabeth V Hillyer, David B Price
PURPOSE: Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS. We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate or non-extrafine beclomethasone). METHODS: This historical, matched cohort study included patients aged 12-60 years prescribed their first ICS as ciclesonide or fine-particle ICS. The 2 cohorts were matched 1:1 for key demographic and clinical characteristics over the baseline year...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27979015/inhaled-corticosteroids-effects-on-growth-and-bone-health
#8
David P Skoner
BACKGROUND: Both slowed growth in children and reduced bone mineral density (BMD) are systemic effects of corticosteroids, and there is concern about the degree to which these systemic effects affect growth and BMD. OBJECTIVE: To engage in a data-driven discussion of the effects of inhaled corticosteroids (ICSs) on growth in children and BMD. METHODS: Articles were selected based on their relevance to this review. RESULTS: Studies of ICSs in children in which growth was a secondary outcome have revealed slowed growth associated with low doses of budesonide, fluticasone propionate, and beclomethasone dipropionate...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27931302/new-insights-into-treatment-of-children-with-exercise-induced-asthma-symptoms
#9
RANDOMIZED CONTROLLED TRIAL
Iwona Stelmach, Anna Sztafiska, Joanna Jerzyska, Daniela Podlecka, Pawe Majak, Wodzimierz Stelmach
BACKGROUND: Exercise is one of the most common triggers of bronchoconstriction and affects up to 80% of children with asthma. OBJECTIVE: The purpose of this randomized, double-blind, placebo-controlled study was to assess the effectiveness of treatment with ciclesonide 160 microgram, either alone, with a higher dose, with a leukotriene receptor antagonist (LTRA), or with a long-acting beta-agonist (LABA) in children with asthma with postexercise-induced symptoms...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931289/measures-to-reduce-maintenance-therapy-with-oral-corticosteroid-in-adults-with-severe-asthma
#10
Vivi Q Nguyen, Charlotte S Ulrik
BACKGROUND: Maintenance therapy with oral corticosteroid (OCS) is used, although not based on evidence, for patients with severe asthma, but OCS is associated with serious adverse effects; therefore, management strategies aimed at steroid sparing are important. OBJECTIVE: To provide an update on the evidence for OCS-sparing strategies in adults with severe asthma. METHODS: A systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27919315/implication-of-alternative-minimal-clinically-important-difference-threshold-estimation-methods-on-technology-assessment
#11
Diana Brixner, Eli O Meltzer, Kellie Morland, Cathryn A Carroll, Ullrich Munzel, Brian J Lipworth
OBJECTIVES: Various minimal clinically important difference (MCID) threshold estimation techniques have been applied to seasonal allergic rhinitis (SAR). The objectives of this study are to (i) assess the difference in magnitude of alternative SAR MCID threshold estimates and (ii) evaluate the impact of alternative MCID estimates on health technology assessment (HTA). METHODS: Data describing change from baseline of the reflective Total Nasal Symptom Score (rTNSS) for four intranasal SAR treatments were obtained from United States Food and Drug Administration-approved prescribing information...
December 6, 2016: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/27742496/inhaled-corticosteroids-and-voice-problems-what-is-new
#12
Nikolaos Spantideas, Eirini Drosou, Anastasia Bougea, Dimitrios Assimakopoulos
BACKGROUND: Voice problems are the most common and most annoying local side effect of inhaled corticosteroids (ICS), affecting not only patients' treatment compliance but also their quality of life. The literature is very poor regarding prevalence, mechanism, prevention, and management of voice problems attributed to ICS use and especially for the new ICS, ciclesonide. Prevalence of dysphonia seems to be less common with the use of ciclesonide and beclomethasone dipropionate. METHOD: We conducted a bibliography review based on recently published data, including data from the recently introduced ICS, ciclesonide, which are lacking in previous reviews...
October 11, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27582089/vilanterol-and-fluticasone-furoate-for-asthma
#13
REVIEW
Kerry Dwan, Stephen J Milan, Lynne Bax, Nicola Walters, Colin Powell
BACKGROUND: Vilanterol (VI) is a long-acting beta2-agonist (LABA) that binds to the beta2-adrenoceptor on the airway smooth muscle, producing bronchodilation. LABA therapy, which is well established in adults as part of the British Thoracic Society (BTS) Guidelines for the Management of Asthma, leads to improvement in symptoms and lung function and reduction in exacerbations. At present, the commonly used LABAs licensed for use in asthma management (formoterol and salmeterol) require twice-daily administration, whereas VI is a once-daily therapy...
September 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27339407/ciclesonide-a-pro-soft-drug-approach-for-mitigation-of-side-effects-of-inhaled-corticosteroids
#14
Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, Hartmut Derendorf
Inhaled corticosteroids are used as one of the first-line drug therapy in patients with asthma. However, their long-term use is associated with various oropharyngeal and systemic side and adverse effects. Design of pro-soft drug is one of the strategies, which was adopted in the design of ciclesonide for mitigation of side effects usually observed with the use of inhaled corticosteroids. Ciclesonide, a pro-soft drug, is converted to an active metabolite desisobutyryl-ciclesonide in the lungs. The anti-inflammatory effect of desisobutyryl-ciclesonide is much higher than ciclesonide, and therefore, the local effect of the metabolite is higher with lower systemic side effects...
September 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27284755/inhaled-corticosteroid-related-adrenal-suppression-detected-by-poor-growth-and-reversed-with-ciclesonide
#15
Brian S Liddell, John M Oberlin, Daniel P Hsu
INTRODUCTION: This case series intends to highlight the association between decreased linear growth velocity and adrenal suppression in patients receiving inhaled corticosteroids for asthma. A potential treatment option is also discussed. Adrenal suppression secondary to inhaled corticosteroids has previously been reported and is often underrecognized. A decrease in linear height velocity has also been associated with inhaled corticosteroids. However, a decrease in height velocity has not been shown to predict adrenal suppression...
January 2, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27185990/a-randomized-double-blind-study-comparing-the-efficacy-and-safety-of-a-combination-of-formoterol-and-ciclesonide-with-ciclesonide-alone-in-asthma-subjects-with-moderate-to-severe-airflow-limitation
#16
Sundeep S Salvi, Abhijit J Vaidya, Rahul R Kodgule, Jaideep A Gogtay
CONTEXT: The combination of inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) is widely used in the treatment of moderate-to-severe asthma uncontrolled by ICS alone. AIMS: To evaluate the efficacy and safety of a new ICS-LABA combination inhaler containing Formoterol (F) and Ciclesonide (C). SETTINGS AND DESIGN: A double-blind, double-dummy, parallel group fashion, multi-centric study. SUBJECTS AND METHODS: A total of 169 asthma patients received Ciclesonide 80 μg once daily during a 4-week run-in period, after which, they were randomized to receive either C (80 μg) or a combination of F (4...
May 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27184175/effectiveness-of-initiating-extrafine-particle-versus-fine-particle-inhaled-corticosteroids-as-asthma-therapy-in-the-netherlands
#17
COMPARATIVE STUDY
Thys van der Molen, Dirkje S Postma, Richard J Martin, Ron M C Herings, Jetty A Overbeek, Victoria Thomas, Cristiana Miglio, Richard Dekhuijzen, Nicolas Roche, Theresa Guilbert, Elliot Israel, Wim van Aalderen, Elizabeth V Hillyer, Simon van Rysewyk, David B Price
BACKGROUND: Most randomised clinical trials typically exclude a significant proportion of asthma patients, including those at higher risk of adverse events, with comorbidities, obesity, poor inhaler technique and adherence, or smokers. However, these patients might differentially benefit from extrafine-particle inhaled corticosteroids (ICS). This matched cohort, database study, compared the effectiveness of extrafine-particle with fine-particle ICS in a real-life population initiating ICS therapy in the Netherlands...
May 17, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27160342/association-of-symptom-control-with-changes-in-lung-function-bronchial-hyperresponsiveness-and-exhaled-nitric-oxide-after-inhaled-corticosteroid-treatment-in-children-with-asthma
#18
Geun-Mi Park, Hye Won Han, Jae Youn Kim, Eun Lee, Hyun-Ju Cho, Jisun Yoon, Soo-Jong Hong, Song-I Yang, Hyeon-Jong Yang, Jinho Yu
BACKGROUND: A key therapeutic approach to asthma, which is characterized by chronic airway inflammation, is inhaled corticosteroid (ICS). This study evaluated the association of symptom control with changes in lung function, bronchial hyperresponsiveness (BHR), and exhaled nitric oxide (eNO) after ICS treatment in asthmatic children. METHODS: A total of 33 children aged between 5 and 12 years with mild to moderate persistent asthma were treated with 160 μg ciclesonide per day for 3 months...
October 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27115215/different-types-of-intranasal-steroids-for-chronic-rhinosinusitis
#19
REVIEW
Lee Yee Chong, Karen Head, Claire Hopkins, Carl Philpott, Martin J Burton, Anne G M Schilder
BACKGROUND: This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Topical (intranasal) corticosteroids are used with the aim of reducing inflammation in the sinonasal mucosa in order to improve patient symptoms...
April 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26852062/ciclesonide-induced-bronchospasm-an-important-but-preventable-side-effect
#20
Payal H Mandaliya, Brendan Kennedy, Peter van Asperen, Paul D Robinson
No abstract text is available yet for this article.
September 7, 2015: Medical Journal of Australia
keyword
keyword
23787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"