keyword
https://read.qxmd.com/read/38700687/contemporary-management-of-pediatric-brainstem-tumors
#1
REVIEW
Sheng-Che Chou, Yu-Ning Chen, Hsin-Yi Huang, Meng-Fai Kuo, Tai-Tong Wong, Sung-Hsin Kuo, Shih-Hung Yang
Brain tumors are the second most common malignancy in childhood. Around 15-20% of pediatric brain tumors occur in the brainstem. The most common type of brainstem tumor are diffuse tumors in the ventral pons, whereas focal tumors tend to arise from the midbrain, medulla, and dorsal pons. Glioma is the most common pathological entity. Contemporary management consists of surgery, radiotherapy, chemotherapy, and other adjuvant treatment. Surgical options range from biopsy to radical excision. Biopsy can be performed for diagnostic and prognostic purposes, or in the setting of clinical trials, mainly for diffuse intrinsic pontine gliomas...
2024: Advances and Technical Standards in Neurosurgery
https://read.qxmd.com/read/38694785/ewing-sarcoma-of-the-pancreas-a-pediatric-case-report-and-narrative-literature-review
#2
Zhensheng Liu, Jian Bian, Yong Yang, Decheng Wei, Shiqin Qi
Ewing's Sarcoma (ES) is an rare, small round-cell sarcoma that predominantly occurs in children and young adults, with both skeletal and extraskeletal manifestations. However, pancreatic ES, due to its rarity, is infrequently featured in scholarly literature, with only a scant 43 reported instances. Our study describes a case of pancreatic ES in an 8-year-old boy who was found to have an abdominal mass. Following an exhaustive examination, the boy was diagnosed with a neoplasm in the pancreatic head and underwent a complex surgical procedure encompassing pancreatoduodenectomy and partial transverse colectomy...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38693667/responding-to-the-need-an-evaluation-of-the-subspecialty-units-in-a-pediatric-surgical-department-in-a-limited-resource-setting-using-selected-optimal-resources-for-children-s-surgery-strategies
#3
JOURNAL ARTICLE
T R Govender, J Scribante, T Govender, A Withers, J A Loveland
BACKGROUND: The Global Initiative for Children's Surgery group published the Optimal Resources for Children's Surgery (OReCS) document outlining the essential criteria and strategies for children's surgical care in low-resource settings. Limited data exist on subspecialties in pediatric surgery and their contribution to global surgery efforts. The study aimed to evaluate the development of subspecialty units within Chris Hani Baragwanath Academic Hospital (CHBAH) Department of Pediatric Surgery (DPS) from January 1, 2018 to December 31, 2021 using selected OReCS strategies for the improvement of pediatric surgery...
May 1, 2024: World Journal of Surgery
https://read.qxmd.com/read/38691048/diagnostic-value-of-the-pediatric-bleeding-questionnaire-in-prediction-of-bleeding-in-minor-surgery
#4
JOURNAL ARTICLE
Ayşe Çakil Güzin, Yeşim Oymak, Akgün Oral, Canan Vergin
OBJECTIVE: Preoperative coagulation tests have not been shown to be effective in predicting bleeding complications. The Pediatric Bleeding Questionnaire (PBQ) is a proven and sensitive tool for diagnosing children with a predisposition to bleeding. The aim of this study was to evaluate the usefulness of PBQ as a preoperative screening tool for the prediction of bleeding after minor surgical interventions. METHODS: Preoperative coagulation tests and PBQ were performed in all patients who underwent minor surgery...
April 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38689623/focus-on-current-and-emerging-treatment-options-for-glioma-a-comprehensive-review
#5
REVIEW
Brandon Lucke-Wold, Burhanuddin Sohail Rangwala, Muhammad Ashir Shafique, Mohammad Arham Siddiq, Muhammad Saqlain Mustafa, Fnu Danish, Rana Muhammad Umer Nasrullah, Noor Zainab, Abdul Haseeb
This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas (LGG), the predominant primary tumors in the central nervous system. With a general incidence rate of 5.81 per 100000, gliomas pose a significant global concern, necessitating advancements in treatment techniques to reduce mortality and morbidity. This review places a particular focus on immunotherapies, discussing promising agents such as Zotiraciclib and Lerapolturev. Zotiraciclib, a CDK9 inhibitor, has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies, showing its potential as a therapeutic breakthrough...
April 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38680063/after-the-t%C3%A3-rkiye-earthquake-the-experience-of-a-pediatric-emergency-department-in-a-university-hospital-distant-from-the-disaster-area
#6
JOURNAL ARTICLE
Burcu Akbaba, Hande Yiğit, Emre Güngör, Mustafa O Kaynak, Hafize H Kahya, Ahmet Z Birbilen, Selman Kesici, Ali Düzova, Benan Bayrakçı, Özlem Tekşam
INTRODUCTION: Earthquakes rank among the most deadly natural disasters, and children are particularly affected due to their inherent vulnerability. Following an earthquake, there is a substantial increase in visits to emergency services. These visits stem not only from patients seeking care for physical traumas resulting from the earthquake and its subsequent complications, but also from individuals affected by the circumstances created by the disaster. STUDY OBJECTIVE: This study aims to determine the characteristics and outcomes of children who presented to the pediatric emergency department (PED) after the earthquake and to evaluate children who had crush injuries at a referral tertiary university hospital away from the earthquake area...
April 29, 2024: Prehospital and Disaster Medicine
https://read.qxmd.com/read/38679864/survival-outcomes-in-pediatric-patients-with-metastatic-ewing-sarcoma-who-achieve-a-rapid-complete-response-of-pulmonary-metastases
#7
JOURNAL ARTICLE
Audra J Reiter, Lynn Huang, Brian T Craig, Andrew M Davidoff, Lindsay J Talbot, Jordan Coggins, Jasmine Smith, Jennifer H Aldrink, Katherine C Bergus, Taleen A MacArthur, Stephanie F Polites, Chloe Boehmer, Joseph Brungardt, Marcus M Malek, Hannah N Rinehardt, Zachary J Kastenberg, Cameron M Arkin, Antoine Gourmel, Nelson Piche, Marshall Wallace, Jiancong Liang, Harold N Lovvorn, Robin T Petroze, Gwendolyn Gillies, John P Marquart, Kerri Becktell, Hau D Le, Juan Favela, Barrie S Rich, Richard D Glick, Natashia M Seemann, Jacob Davidson, Claire A Wilson, Jonathan Roach, Erin G Brown, Kathleen E Doyle, Brian A Coakley, Pamela Emengo, Pamela Merola, Christa N Grant, Anuritha Tirumani, Elisabeth T Tracy, Mary E Moya-Mendez, Roshni Dasgupta, Timothy B Lautz
PURPOSE: Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non-RCR). PATIENTS AND METHODS: This retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative...
April 28, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38676786/podcast-on-emerging-treatment-options-for-pediatric-patients-with-alk-positive-anaplastic-large-cell-lymphoma-and-inflammatory-myofibroblastic-tumors
#8
JOURNAL ARTICLE
Eric Lowe, Yael P Mossé
Anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT) are rare cancers observed predominantly in children and young adults. ALCL accounts for 10-15% of all pediatric non-Hodgkin lymphomas and is commonly diagnosed at an advanced stage of disease. In children, 84-91% of cases of ALCL harbor an anaplastic lymphoma kinase (ALK) gene translocation. IMT is a rare mesenchymal neoplasm that also tends to occur in children and adolescents. Approximately 50-70% of IMT cases involve rearrangements in the ALK gene...
April 27, 2024: Oncology and Therapy
https://read.qxmd.com/read/38665953/plasma-mirna-expression-profile-in-pediatric-pineal-pure-germinomas
#9
JOURNAL ARTICLE
Mona Fakhry, Moatasem Elayadi, Mariam G Elzayat, Omar Samir, Eslam Maher, Hala Taha, Mohamed El-Beltagy, Amal Refaat, Manal Zamzam, Mohamed S Abdelbaki, Ahmed A Sayed, Mark Kieran, Alaa Elhaddad
BACKGROUND: Pure germinomas account for 40% of pineal tumors and are characterized by the lack of appreciable tumor markers, thus requiring a tumor biopsy for diagnosis. MicroRNAs (miRNA) have emerged as potential non-invasive biomarkers for germ cell tumors and may facilitate the non-invasive diagnosis of pure pineal germinomas. MATERIAL AND METHODS: A retrospective chart review was performed on all patients treated at the Children's Cancer Hospital Egypt diagnosed with a pineal region tumor between June 2013 and March 2021 for whom a research blood sample was available...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38662222/role-of-sodium-fluorescein-in-pediatric-low-grade-glioma-surgery-an-update
#10
JOURNAL ARTICLE
Camilla de Laurentis, Claudia Pasquali, Pierre-Aurélien Beuriat, Carmine Mottolese, Alexandru Szathmari, Matthieu Vinchon, Federico Di Rocco
PURPOSE: Complete surgical resection is still the mainstay in the treatment of central nervous system low-grade tumors, eventually resulting curative. The complete surgical removal of these lesions, however, may be difficult in some cases because of their infiltrative nature. Intraoperative adjuncts may be a game changer. Sodium fluorescein (SF) is among the ideal candidates as intraoperative tools to favor the actual recognition of the tumor extension, since it accumulates in areas of altered blood-brain barrier, a typical characteristic of pediatric gliomas, and has a low rate of adverse events...
April 25, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38651631/the-use-of-vascularized-fibula-flap-with-allograft-in-post-oncologic-microsurgical-bone-reconstruction-of-lower-limbs-in-pediatric-patients
#11
JOURNAL ARTICLE
Delcroix Luca, Tamburello Sara, Innocenti Marco, Campanacci Domenico Andrea
BACKGROUND: Post-oncologic surgical reconstruction of lower limbs in pediatrics remains a challenging topic. Microsurgical techniques allow reconstructions of large bony defects. The use of vascularized fibular flap with allograft has proven to be an ideal biologic construct. We aim to assess the success rate of this operation, including flap survival, bony union, weight-bearing ambulation, and complications in a long-term follow-up in our case series compared to the literature. PATIENTS AND METHODS: Our case-series includes 18 femoral resections (9 osteosarcomas, 8 Ewing sarcoma, and 1 desmoid tumor) and 15 tibial resections (10 osteosarcoma, 4 Ewing sarcoma, and 1 Malignant Fibrous Histiocytoma)...
May 2024: Microsurgery
https://read.qxmd.com/read/38647646/screening-and-surveillance-recommendations-for-central-nervous-system-hemangioblastomas-in-pediatric-patients-with-von-hippel-lindau-disease
#12
JOURNAL ARTICLE
Anna Laura Knoblauch, B-I Blaß, C Steiert, N Neidert, A Puzik, E Neumann-Haefelin, A Ganner, F Kotsis, T Schäfer, H P H Neumann, S Elsheikh, J Beck, J-H Klingler
PURPOSE: Von Hippel-Lindau (VHL) disease is an autosomal-dominantly inherited tumor predisposition syndrome. One of the most common tumors are central nervous system (CNS) hemangioblastomas. Recommendations on the initiation and continuation of the screening and surveillance program for CNS tumors in pediatric VHL patients are based on small case series and thus low evidence level. To derive more robust screening recommendations, we report on the largest monocentric pediatric cohort of VHL patients...
April 22, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38646358/pediatric-prostatic-alveolar%C3%A2-rhabdomyosarcoma-presenting-with-metastatic-spinal-cord-compression-in-the-thoracic-spine-a-case-report-and-review-of-the-literature
#13
Matthew T Perry, Andrew J Witten, Majeed Marwan, Alexander Vortmeyer, Jignesh Tailor
Rhabdomyosarcoma (RMS) is a pediatric malignancy with a variable prognosis depending on tumor stage and genotype. There has been a significant improvement in survival rates over the past decades. However, aggressive variants can metastasize to locations that are difficult to treat. We report a case of prostatic alveolar rhabdomyosarcoma with metastases to the bone marrow and thoracic spine in a child. The patient was treated with a multimodal approach that included surgical resection of the epidural mass; the administration of vincristine, dactinomycin, and cyclophosphamide; and radiotherapy...
March 2024: Curēus
https://read.qxmd.com/read/38643155/clinical-implications-of-pediatric-biliary-intraepithelial-neoplasia-diagnosed-from-a-choledochal-cyst-specimen
#14
JOURNAL ARTICLE
Sujin Gang, Hyunhee Kwon, In Hye Song, Jung-Man Namgoong
BACKGROUND: Biliary intraepithelial neoplasia (BilIN), a noninvasive precursor of cholangiocarcinoma, can manifest malignant transformation. Since cholangiocarcinoma (CCA) may progress due to chronic inflammation in the bile ducts and gallbladder, choledochal cysts are considered a precursor to CCA. However, BilIN has rarely been reported in children, to date. METHODS: We reviewed medical records of patients (< 18 years of age, n = 329) who underwent choledochal cyst excision at Asan Medical Center from 2008 to 2022...
April 20, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38637207/central-venous-catheter-consideration-in-pediatric-oncology-a-systematic-review-and-meta-analysis-from-the-american-pediatric-surgical-association-cancer-committee
#15
JOURNAL ARTICLE
Emily R Christison-Lagay, Erin G Brown, Jennifer Bruny, Melissa Funaro, Richard D Glick, Roshni Dasgupta, Christa N Grant, Abigail J Engwall-Gill, Timothy B Lautz, David Rothstein, Ashley Walther, Peter F Ehrlich, Jennifer H Aldrink, David Rodeberg, Reto M Baertschiger
BACKGROUND: Tunneled central venous catheters (CVCs) are the cornerstone of modern oncologic practice. Establishing best practices for catheter management in children with cancer is essential to optimize care, but few guidelines exist to guide placement and management. OBJECTIVES: To address four questions: 1) Does catheter composition influence the incidence of complications; 2) Is there a platelet count below which catheter placement poses an increased risk of complications; 3) Is there an absolute neutrophil count (ANC) below which catheter placement poses an increased risk of complications; and 4) Are there best practices for the management of a central line associated bloodstream infection (CLABSI)? METHODS: Data Sources: English language articles in Ovid Medline, PubMed, Embase, Web of Science, and Cochrane Databases...
March 27, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38616844/penile-epithelioid-hemangioendothelioma-in-a-child
#16
Palak Singhai, Nitin James Peters, Aravind Sekar, Girdhar S Bora, Ujjwal Gorsi, Jai Kumar Mahajan
An 8-year-old boy initially thought to have a penile arteriovenous malformation was later diagnosed with a rare vascular sarcoma, epithelioid hemangioendothelioma (EHE). Despite challenges in diagnosis, he underwent supraselective angioembolization and partial penectomy for oncological clearance. EHE, a low-grade malignancy, requires prompt identification and treatment due to potential systemic involvement.
2024: Journal of Indian Association of Pediatric Surgeons
https://read.qxmd.com/read/38609910/impact-of-the-covid-19-pandemic-in-childhood-and-adolescent-cancer-care-in-northern-tanzania-a-cross-sectional-study
#17
JOURNAL ARTICLE
Yotham Gwanika, Hannah E Rice, Madeline Metcalf, Pamela Espinoza, Happiness D Kajoka, Henry E Rice, Catherine Staton, Blandina T Mmbaga, Esther Majaliwa, Emily R Smith, Cesia Cotache-Condor
INTRODUCTION: The SARS-CoV-2 (COVID-19) pandemic has strained healthcare systems and presented unique challenges for children requiring cancer care, particularly in low- and middle-income countries. This study aimed to assess the impact of the COVID-19 pandemic on access to cancer care for children and adolescents in Northern Tanzania. METHODS: In this cross-sectional study, we assessed the demographic and clinical characteristics of 547 pediatric and adolescent cancer patients (ages 0-19 years old) between 2016 and 2022 using the population-based Kilimanjaro Cancer Registry (KCR)...
April 12, 2024: BMC Cancer
https://read.qxmd.com/read/38608813/intraventricular-glioma-in-pediatric-patients-a-systematic-review-of-demographics-clinical-characteristics-and-outcomes
#18
REVIEW
Gina Watanabe, Andie Conching, Lane Fry, Dillon Putzler, Mohammad Faizan Khan, Mohammad Ammar Haider, Ali S Haider, Gianluca Ferini, Freddie Yamel Rodriguez-Beato, Mayur Sharma, Giuseppe E Umana, Paolo Palmisciano
OBJECTIVE: We conducted a systematic review on pediatric intraventricular gliomas to survey the patient population, tumor characteristics, management, and outcomes. METHODS: PubMed, Scopus, Web-of-Science, and Cochrane were searched using PRISMA guidelines to include studies reporting pediatric patients with intraventricular gliomas. RESULTS: A total of 30 studies with 317 patients were included. Most patients were male (54%), diagnosed at a mean age of 8 years (0...
April 10, 2024: World Neurosurgery
https://read.qxmd.com/read/38607550/pediatric-hemispheric-cerebellar-low-grade-gliomas-clinical-approach-diagnosis-and-management-challenges-experience-at-a-tertiary-care-children-s-hospital
#19
REVIEW
Santiago Ezequiel Cicutti, Ramiro José Del Río, Adrian Cáceres, Javier Danilo Gonzalez Ramos
PURPOSE: This study aims to provide an exhaustive analysis of pediatric low-grade gliomas (pLGGs) in the cerebellar hemispheres, focusing on incidence, clinical characteristics, surgical outcomes, and prognosis. It seeks to enhance understanding and management of pLGGs in the pediatric population. METHODS: We conducted an observational, descriptive, retrospective, and cross-sectional study at a pediatric hospital, reviewing medical records of 30 patients with cerebellar hemispheric pLGGs treated from December 2014 to January 2023...
April 12, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38607453/bilateral-adrenal-neuroblastoma-peculiar-pattern-of-a-rare-pediatric-presentation
#20
JOURNAL ARTICLE
Mohamed Fawzy, Gehad Ahmed, Yasser Youssef, Naglaa Elkinaai, Amal Refaat, Mai Amr Elahmadawy, Fadwa Said, Salma Elmenawi
BACKGROUND: Bilateral suprarenal neuroblastoma (BSN) is a rare presentation. Few previously published literature showed BSN patients to have favorable pattern and prognosis. This study aim was to evaluate clinical and biological features in relation to outcome of Egyptian patients with BSN. METHODS: Included patients were diagnosed from 2007 to 2017, retrospectively. Tissue biopsy, imaging and bone marrow were evaluated at presentation. Clinical, demographic, biological variables and risk group were determined and analyzed in relation to overall (OS) and event-free-survival (EFS)...
April 12, 2024: Discover. Oncology
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