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https://www.readbyqxmd.com/read/28643070/laparoscopic-revision-of-billroth-ii-with-braun-anastomosis-into-roux-en-y-anatomy-in-a-patient-with-intestinal-malrotation
#1
Fabio Garofalo, Omar Abouzahr, Henri Atlas, Ronald Denis, Pierre Garneau, Hai Huynh, Radu Pescarus
INTRODUCTION: Various reconstructions of the gastro-intestinal tract have been described in the past after distal gastrectomy. Among these, a Billroth II (BII) anastomosis can be performed with the addition of the Omega entero-enterostomy that may theoretically reduce the alkaline reflux. Given the significant complications associated with this procedure such as biliary reflux, marginal ulceration, and afferent loop syndrome, a revision into a Roux-en-Y anatomy is generally recommended...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28633399/the-interfacial-character-of-antibody-paratopes-analysis-of-antibody-antigen-structures
#2
Minh N Nguyen, Mohan R Pradhan, Chandra Verma, Pingyu Zhong
Summary: In this study, computational methods are applied to investigate the general properties of antigen engaging residues of a paratope from a non-redundant dataset of 403 antibody-antigen complexes to dissect the contribution of hydrogen bonds, hydrophobic, van der Waals contacts and ionic interactions, as well as role of water molecules in the antigen-antibody interface. Consistent with previous reports using smaller datasets, we found that Tyr, Trp, Ser, Asn, Asp, Thr, Arg, Gly, His contribute substantially to the interactions between antibody and antigen...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28597287/comparison-of-endoscopic-sphincterotomy-techniques-after-billroth-ii-gastrectomy-using-a-novel-mechanical-simulator
#3
Mohamed Abdelhafez, Eckart Frimberger, Peter Klare, Bernhard Haller, Roland M Schmid, Stefan von Delius
BACKGROUND AND AIMS: A postsurgical anatomy renders endoscopic sphincterotomy (EST) more challenging. Although different EST techniques for such a situation exist, comparative studies are lacking. The aim of the study was to compare the efficacy of different EST techniques using a novel mechanical simulator. METHODS: Ten expert endoscopists performed 6 different EST techniques on a novel mechanical Billroth II (BII) simulator in a random sequence. The EST techniques were (1) standard sphincterotome used with a side-viewing endoscope, (2) BII sphincterotome used with a side-viewing endoscope, (3) needle-knife EST guided by biliary endoprosthesis used with a side-viewing endoscope, (4) standard sphincterotome used with a forward-viewing endoscope, (5) BII sphincterotome used with a forward-viewing endoscope, and (6) needle-knife EST guided by biliary endoprosthesis used with a forward-viewing endoscope...
June 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28585420/quantitative-biogeography-of-picoprasinophytes-establishes-ecotype-distributions-and-significant-contributions-to-marine-phytoplankton
#4
Alexander J Limardo, Sebastian Sudek, Chang Jae Choi, Camille Poirier, Yoshimi M Rii, Marguerite Blum, Robyn Roth, Ursula Goodenough, Matthew J Church, Alexandra Z Worden
Bathycoccus and Ostreococcus are broadly distributed marine picoprasinophyte algae. We enumerated small phytoplankton using flow cytometry and qPCR assays for phylogenetically distinct Bathycoccus clades BI and BII and Ostreococcus clades OI and OII. Among 259 photic-zone samples from transects and time-series, Ostreococcus maxima occurred in the North Pacific coastal upwelling for OI (36,713 ± 1,485 copies ml(-1) ) and the Kuroshio Front for OII (50,189 ± 561 copies ml(-1) ) and the two overlapped only in frontal regions...
June 5, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28577527/misdiagnosis-of-hiv-treatment-failure-based-on-clinical-and-immunological-criteria-in-eastern-and-central-kenya
#5
Sunguti Luke Joram, Gathii Paul, Kitheka Moses, Bii Stanley, Malonza Isaac, Gohole Allan, Marwa Tom, Karimi Lilian, Mudany Mildred
BACKGROUND: Routine laboratory monitoring is part of the basic care package offered to people living with the Human Immunodeficiency Virus (PLHIV). This paper aims to identify the proportion of PLHIVs with clinical and immunological failure who are virologically suppressed and risk being misclassified as treatment failures. METHODS: A retrospective analysis of patient viral load data collected between January 2013 and June 2014 was conducted. Of the patients classified as experiencing either clinical or immunological failure, we evaluated the proportion of true (virological) failure, and estimated the sensitivity and specificity of the immunological and clinical criteria in diagnosing true treatment failure...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28574448/simultaneous-quantification-of-multiple-representative-components-in-the-xian-ling-gu-bao-capsule-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#6
Zhi-Hong Yao, Zi-Fei Qin, Hong Cheng, Xiao-Meng Wu, Yi Dai, Xin-Luan Wang, Ling Qin, Wen-Cai Ye, Xin-Sheng Yao
Xian-Ling-Gu-Bao capsule (XLGB), a famous traditional Chinese medicine prescription, is extensively used for the treatment of osteoporosis in China. However, few studies on the holistic quality control of XLGB have been reported. In this study, a reliable method using 18 representative components in XLGB was successfully established and applied to evaluate 34 batches of XLGB samples by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The choice of quantitative markers mostly followed four principles, i...
June 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28554939/simplified-clinical-algorithm-for-identifying-patients-eligible-for-immediate-initiation-of-antiretroviral-therapy-for-hiv-slate-protocol-for-a-randomised-evaluation
#7
Sydney Rosen, Matthew P Fox, Bruce A Larson, Alana T Brennan, Mhairi Maskew, Isaac Tsikhutsu, Margaret Bii, Peter D Ehrenkranz, Wd Francois Venter
INTRODUCTION: African countries are rapidly adopting guidelines to offer antiretroviral therapy (ART) to all HIV-infected individuals, regardless of CD4 count. For this policy of 'treat all' to succeed, millions of new patients must be initiated on ART as efficiently as possible. Studies have documented high losses of treatment-eligible patients from care before they receive their first dose of antiretrovirals (ARVs), due in part to a cumbersome, resource-intensive process for treatment initiation, requiring multiple clinic visits over a several-week period...
May 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28539647/physiological-concentrations-of-soluble-uric-acid-are-chondroprotective-and-anti-inflammatory
#8
Jenn-Haung Lai, Shue-Fen Luo, Li-Feng Hung, Chuan-Yueh Huang, Shiu-Bii Lien, Leou-Chyr Lin, Feng-Cheng Liu, B Linju Yen, Ling-Jun Ho
High uric acid levels are a risk factor for cardiovascular disorders and gout; however, the role of physiological concentrations of soluble uric acid (sUA) is poorly understood. This study aimed to clarify the effects of sUA in joint inflammation. Both cell cultures of primary porcine chondrocytes and mice with collagen-induced arthritis (CIA) were examined. We showed that sUA inhibited TNF-α- and interleukin (IL)-1β-induced inducible nitric oxide synthase, cyclooxygenase-2 and matrix metalloproteinase (MMP)-13 expression...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487918/heteroannulation-enabled-by-a-bimetallic-rh-iii-ag-i-relay-catalysis-application-in-the-total-synthesis-of-aristolactam-bii
#9
Wei-Wei Ji, E Lin, Qingjiang Li, Honggen Wang
A redox-neutral bimetallic Rh(iii)/Ag(i) relay catalysis allowed the efficient construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The Rh(iii) catalyst was responsible for the C-H monofluoroalkenylation reaction, whereas the Ag(i) salt was an activator for the follow-up cyclization. The methodology developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.
May 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28451019/prevalence-aetiology-and-antibiotic-sensitivity-profile-of-asymptomatic-bacteriuria-isolates-from-pregnant-women-in-selected-antenatal-clinic-from-nairobi-kenya
#10
Adelaide Ogutu Ayoyi, Gideon Kikuvi, Christine Bii, Samuel Kariuki
INTRODUCTION: Asymptomatic bacteriuria (ASB) is the presence of bacteria in urine without apparent symptoms of urinary tract infections. The importance of asymptomatic bacteriuria lies in the insight it provides into symptomatic infections. To determine prevalence, bacterial isolates and Antibiotic Sensitivity Profile of asymptomatic bacterial urinary tract infection in pregnant women in selected clinics in Nairobi. METHODS: This was a cross-sectional study involving women attending antenatal clinic at selected clinics of Nairobi County...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28445094/proteinases-during-early-development-of-the-pacific-whiteleg-shrimp-penaeus-vannamei
#11
Patricia Hernandez-Cortes, Crisalejandra Rivera-Pérez, Fernando García-Carreño, Diana Martínez-Alarcón
During shrimp larval development, changes occur in molecular components. Enzyme activity and mRNA expression of proteinases were assayed in Penaeus vannamei during larval development, which consists of 5 nauplius stages, 3 protozoeal stages, 3 mysis stages, and 12 postlarval stages. Trypsin activity reached a maximum at the beginning of postlarval stages 1 and 2, and significantly decreased in subsequent postlarval stages. Chymotrypsin activity increased at the third protozoeal stage, then significantly decreased in subsequent stages...
February 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28423002/human-sr-bii-mediates-saa-uptake-and-contributes-to-saa-pro-inflammatory-signaling-in-vitro-and-in-vivo
#12
Irina N Baranova, Ana C P Souza, Alexander V Bocharov, Tatyana G Vishnyakova, Xuzhen Hu, Boris L Vaisman, Marcelo J Amar, Zhigang Chen, Alan T Remaley, Amy P Patterson, Peter S T Yuen, Robert A Star, Thomas L Eggerman
Serum amyloid A (SAA) is an acute phase protein with cytokine-like and chemotactic properties, that is markedly up-regulated during various inflammatory conditions. Several receptors, including FPRL-1, TLR2, TLR4, RAGE, class B scavenger receptors, SR-BI and CD36, have been identified as SAA receptors. This study provides new evidence that SR-BII, splice variant of SR-BI, could function as an SAA receptor mediating its uptake and pro-inflammatory signaling. The uptake of Alexa Fluor488 SAA was markedly (~3 fold) increased in hSR-BII-expressing HeLa cells when compared with mock-transfected cells...
2017: PloS One
https://www.readbyqxmd.com/read/28408892/conceptualizing-the-dynamics-between-bicultural-identification-and-personal-social-networks
#13
Lydia Repke, Verónica Benet-Martínez
An adequate understanding of the acculturation processes affecting immigrants and their descendants involves ascertaining the dynamic interplay between the way these individuals manage their multiple (and sometimes conflictual) cultural value systems and identifications and possible changes in their social networks. To fill this gap, the present research examines how key acculturation variables (e.g., strength of ethnic/host cultural identifications, bicultural identity integration or BII) relate to the composition and structure of bicultural individuals' personal social networks...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28391381/osseointegration-improves-bone-implant-interface-of-pedicle-screws-in-the-growing-spine-a-biomechanical-and-histological-study-using-an-in-vivo-immature-porcine-model
#14
Kanako Shiba, Hiroshi Taneichi, Takashi Namikawa, Satoshi Inami, Daisaku Takeuchi, Yutaka Nohara
PURPOSE: Implant failure is a frequent complication in corrective surgery for early onset scoliosis, since considerable forces are acting on small and fragile vertebrae. Osseointegration showing biomechanical and histological improvement in bone-implant interface (BII) after dental implant placement has been well investigated. However, there are no studies regarding osseointegration in immature vertebral bone. The purpose was to evaluate the timecourse of biomechanical and histological changes at BII after pedicle screw placement using in vivo immature porcine model...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28383294/roux-en-y-or-billroth-ii-reconstruction-after-radical-distal-gastrectomy-for-gastric-cancer-a-multicenter-randomized-controlled-trial
#15
Jimmy Bok-Yan So, Jaideepraj Rao, Andrew Siang-Yih Wong, Yiong-Huak Chan, Ning Qi Pang, Amy Yuh Ling Tay, Man Yee Yung, Zheng Su, Janelle Niam Sin Phua, Asim Shabbir, Enders Kwok Wai Ng
OBJECTIVE: The aim of the study was to compare the clinical symptoms between Billroth II (B-II) and Roux-en-Y (R-Y) reconstruction after distal subtotal gastrectomy (DG) for gastric cancer. BACKGROUND: Surgery is the mainstay of curative treatment for gastric cancer. The technique for reconstruction after DG remains controversial. Both B-II and R-Y are popular methods. METHODS: This is a prospective multicenter randomized controlled trial...
April 5, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28371233/simultaneous-quantitative-determination-of-13-active-components-in-the-traditional-chinese-medicinal-preparation-suanzaoren-oral-liquid-by-hplc-coupled-with-diode-array-detection-and-evaporative-light-scattering-detection
#16
Lin Zhu, Zhenru Wang, Xinran Zhai, Zhenyu Sui, Di Wang, Qing Li, Kaishun Bi, Bosai He, Tiejie Wang
To control the quality of different forms of Suanzaoren decoction, an effective and reliable method for the simultaneous determination of 13 major components (neomangiferin, mangiferin, spinosin, liquiritin apioside, liquiritin, 6'''-feruloylspinosin, senkyunolide I, timosaponin BII, isoliquiritoside, timosaponin C, jujuboside A, jujuboside B, and timosaponin AIII) was developed and validated for the first time in this study using high-performance liquid chromatography with diode array detection and evaporative light scattering detection...
March 31, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28320386/delayed-gastric-emptying-following-pancreatoduodenectomy-with-alimentary-reconstruction-according-to-roux-en-y-or-billroth-ii
#17
Tim R Glowka, Markus Webler, Hanno Matthaei, Nico Schäfer, Volker Schmitz, Jörg C Kalff, Jens Standop, Steffen Manekeller
BACKGROUND: Delayed gastric emptying (DGE) remains the most frequent complication following pancreatoduodenectomy (PD) with published incidences as high as 61%. The present study investigates the impact of bowel reconstruction techniques on DGE following classic PD (Whipple-Kausch procedure) with pancreatogastrostomy (PG). METHODS: We included 168 consecutive patients who underwent PD with PG with either Billroth II type (BII, n = 78) or Roux-en-Y type reconstruction (ReY, n = 90) between 2004 and 2015...
March 20, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28294471/ultra-brief-behavioral-skills-trainings-for-blood-injection-injury-phobia
#18
Alicia E Meuret, Erica Simon, Lavanya Bhaskara, Thomas Ritz
BACKGROUND: Blood injection injury (BII) phobia is common, with debilitating consequences to the health and well being of many of its sufferers. BII phobia presents with a unique fear response that can involve drops in blood pressure and ultimately fainting. The aim of this study was to provide proof of concept for a line of brief, easy to implement, video-based interventions for reducing phobic avoidance and fears in BII sufferers. One of the interventions was a novel Hypoventilation Respiratory Training (HRT) aimed at reducing the exaggerated ventilation response (hyperventilation) seen in BII phobia...
March 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28294314/generation-of-precursor-immature-and-mature-murine-b1-cell-lines-from-c-myc-bcl-xl-overexpressing-pre-bi-cells
#19
Inge Wolf, Corinne Bouquet, Friederike Naumann, Fritz Melchers
Deregulated expression of c-myc and bcl-xL is long known to generate transformed B cells in humans and mice. We overexpressed these genes to induce in vitro and in vivo differentiation of fetal liver-derived mouse pre-BI cells to B1-lineage pre-BII-like, immature and mature B-cell lines, and to Ig-secreting cells. In vitro, doxycycline-controlled c-myc/bcl-xL-overexpressing CD19(+) CD93(+) c-kikt(+) IgM(-) pre-BI cells differentiate to and survive as CD19(+) CD93(+) c-kit(-) IgM(+) immature B1 cells. Timed CpG stimulation of these oncogene-overexpressing pre-B or immature B1 cells generates either CD19(+) CD93(low) c-kit(-) IgM(-) SLC(-) pre-BII-like or IgM(+) MHCII(+) CD73(+) CD80(+) CD40(+) mature B1-cell lines and IgM-secreting B1 cells in vitro and fixes their state of differentiation...
May 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28163716/billroth-ii-with-braun-enteroenterostomy-is-a-good-alternative-reconstruction-to-roux-en-y-gastrojejunostomy-in-laparoscopic-distal-gastrectomy
#20
Long-Hai Cui, Sang-Yong Son, Ho-Jung Shin, Cheulsu Byun, Hoon Hur, Sang-Uk Han, Yong Kwan Cho
Background. Although Billroth II (BII) reconstruction is simpler and faster than Billroth I or Roux-en-Y (RY) reconstruction in patients undergoing totally laparoscopic distal gastrectomy (TLDG), BII reconstruction is associated with several complications, including more severe bile reflux. BII Braun anastomosis may be a better alternative to RY reconstruction. Methods. This retrospective study included 56 consecutive patients who underwent TLDG for gastric cancer, followed by BII Braun or RY reconstruction, between January 2013 and December 2015...
2017: Gastroenterology Research and Practice
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