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Coronary Optical Coherence Tomography

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https://www.readbyqxmd.com/read/29678337/relation-of-coronary-culprit-lesion-morphology-determined-by-optical-coherence-tomography-and-cardiac-outcomes-to-serum-uric-acid-levels-in-patients-with-acute-coronary-syndrome
#1
Nobuaki Kobayashi, Noritake Hata, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Masamichi Takano, Yoshihiko Seino, Wataru Shimizu
The aims of the present study were to elucidate features of culprit lesion plaque morphology using optical coherence tomography (OCT) in relation to elevated serum uric acid (sUA) levels and to clarify the impact of sUA levels on adverse clinical outcomes in patients with acute coronary syndrome (ACS). Clinical data and outcomes were compared between ACS patients with sUA ≥6 mg/dl (high-sUA; n = 506) and sUA <6.0 mg/dl (low-sUA; n = 608). Angiography and OCT findings were analyzed in patients with preintervention OCT and compared between groups of high-sUA (n = 206) and low-sUA (n = 273)...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29668639/impact-of-vessel-curvature-on-neointimal-healing-after-stent-implantation-as-assessed-by-optical-coherence-tomography
#2
Yandong Fu, Shaotao Zhang, Hongwei Du, Lulu Li, Chao Wang, Gonghui Zheng, Yan Wang, Hui Dong, Haibo Jia, Bo Yu
PURPOSE: Previous studies have indicated that stent implantation could alter the vessel geometry, which may impact the neointimal healing process. Curvature is an important parameter for evaluating vessel geometry. The purpose of our study was to investigate the relationship between vessel curvature and neointimal healing after stent implantation. METHODS: Fifty-nine patients with acute coronary syndrome (ACS) who underwent stent implantation were enrolled in the study...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29656280/real-world-bioresorbable-vascular-scaffold-experience-compared-with-second-generation-metallic-drug-eluting-stents-in-complex-coronary-lesions
#3
Naotaka Okamoto, Hiroshi Ueda, Takahiro Yoshimura, Surbhi Chamaria, Samit Bhatheja, Yuliya Vengrenyuk, Samaneh Rabiei, Yonandy Barrientos, Vishal Kapur, Nitin Barman, Joseph Sweeny, Usman Baber, Roxana Mehran, Samin K Sharma, Annapoorna S Kini
OBJECTIVES: The aim of the study was to compare the acute outcomes of Absorb bioresorbable vascular scaffolds (BVS) and second-generation drug-eluting stent (DES) implantation in routine clinical practice. There is a paucity of data regarding BVS use in a real-world patient population. METHODS: The study population comprised 40 consecutive patients who underwent percutaneous coronary intervention (PCI) with BVS implantation at a tertiary-care center in New York, New York between July and December of 2016...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29655510/histopathological-validation-of-optical-coherence-tomography-findings-of-the-coronary-arteries
#4
REVIEW
Kenichi Fujii, Rika Kawakami, Seiichi Hirota
Optical coherence tomography (OCT), a catheter-based imaging modality for the visualization of coronary arteries, is widely used during percutaneous coronary intervention to improve the understanding of the anatomy of coronary artery stenosis and to elucidate the mechanisms of atherosclerosis. In this review, we provide a short description of the histopathological validations of OCT for visualizing atherosclerotic plaques and vascular healing response after drug-eluting stent (DES) implantation. Because OCT measures the intensity of light returning from within a tissue, tissue having a higher heterogeneity of optical index of refraction, such as microcalcification deposition and foam cell accumulation on the luminal surface, may exhibit stronger optical scattering that appears as a thin-cap fibroatheroma image...
April 11, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29652433/vasculitis-or-coronary-atherosclerosis-optical-coherence-tomography-images-in-polyarteritis-nodosa
#5
Maciej Lewandowski, Jarosław Gorący, Irmina Kossuth, Małgorzata Peregud-Pogorzelska
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29650398/the-role-of-optical-coherence-tomography-in-the-setting-of-acute-myocardial-infarction
#6
REVIEW
Yongcheol Kim, Thomas W Johnson, Takashi Akasaka, Myung Ho Jeong
In recent years, intravascular imaging-guided percutaneous coronary intervention (PCI) has been increasing in patients with acute myocardial infarction (AMI). However, the role of optical coherence tomography (OCT) has not been established in the setting of AMI despite OCT providing superior resolution (10μm axial resolution) and facilitating assessment of baseline lesion characteristics and post-intervention evaluation of the acute result of stent implantation, including visualization of procedural dissections, malapposition, tissue prolapse, and thrombus...
April 9, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29643697/vascular-healing-response-after-everolimus-eluting-stent-implantation-in-acute-coronary-syndrome-culprit-lesions-comparison-with-implantation-in-stable-angina-pectoris
#7
Yutaka Goryo, Teruyoshi Kume, Tomoya Ueda, Makoto Watanabe, Ryotaro Yamada, Yoji Neishi, Yoshihiko Saito, Shiro Uemura
Background: To evaluate the neointimal conditions of everolimus-eluting stents (EESs) implanted in culprit lesions of patients with acute coronary syndrome (ACS) compared with stable angina pectoris (SAP) using optical coherence tomography (OCT). EESs are second-generation drug-eluting stents that have recently been shown to be useful in patients with ACS as well as in patients with SAP. However, few studies have analyzed the intra-stent conditions of EESs that can lead to favorable results in such ACS lesions...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29623170/a-practical-approach-to-assessing-stent-results-with-ivus-or-oct
#8
REVIEW
Daisuke Hachinohe, Satoru Mitomo, Luciano Candilio, Azeem Latib
Coronary angiography is routinely used to assess the extent and severity of coronary artery disease and for decision-making during percutaneous coronary interventions (PCI). However, it is sometimes inadequate for deciding a strategy and defining optimal stenting outcomes. In this review, we present a comprehensive and practical approach to PCI using intravascular ultrasound or optical coherence tomography to optimize stent deployment and assess procedural complications after stent implantation.
January 2018: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29616627/lumen-boundaries-extracted-from-coronary-computed-tomography-angiography-on-computed-fractional-flow-reserve-ffrct-validation-with-optical-coherence-tomography
#9
Kenzo Uzu, Hiromasa Otake, Gilwoo Choi, Takayoshi Toba, Hyun Jin Kim, Arjun Rou, Michiel Schaap, Leo Grady, Masahito Kawata, Toshiro Shinke, Charles Anthony Taylor, Ken-Ichi Hirata
AIMS: To evaluate the accuracy of minimal lumen area (MLA) by coronary computed tomography angiography (cCTA) and its impact on fractional flow reserve (FFRCT). METHODS AND RESULTS: Fifty-seven patients (118 lesions, 72 vessels) who underwent cCTA and optical coherence tomography (OCT) were enrolled. OCT and cCTA were co-registered and MLAs were measured with both modalities. FFROCT was calculated using OCT-updated models with cCTA-based lumen geometry replaced by OCT-derived geometry...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29616625/plaque-burden-influences-accurate-classification-of-fibrous-cap-atheroma-by-in-vivo-optical-coherence-tomography-in-a-porcine-model-of-advanced-coronary-atherosclerosis
#10
Christian B Poulsen, Ryan M Pedrigi, Nilesh Pareek, Ismail D Kilic, Niels Ramsing Holm, Jacob F Bentzon, Hans Erik Bøtker, Erling Falk, Rob Krams, Ranil de Silva
AIMS: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. METHODS AND RESULTS: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29607444/oct-based-three-dimensional-modeling-of-stent-deployment
#11
Pengfei Dong, David Prabhu, David L Wilson, Hiram G Bezerra, Linxia Gu
Stent deployment has been widely used to treat narrowed coronary artery. Its acute outcome in terms of stent under expansion and malapposition depends on the extent and shape of calcifications. However, no clear understanding as to how to quantify or categorize the impact of calcification. We have conducted ex vivo stenting characterized by the optical coherence tomography (OCT). The goal of this work is to capture the ex vivo stent deployment and quantify the effect of calcium morphology on the stenting. A three dimensional model of calcified plaque was reconstructed from ex vivo OCT images...
November 2017: International Mechanical Engineering Congress and Exposition: [proceedings]
https://www.readbyqxmd.com/read/29602326/type-d-personality-and-coronary-atherosclerotic-plaque-vulnerability-the-potential-mediating-effect-of-health-behavior
#12
Fangman Cheng, Ping Lin, Yini Wang, Guojie Liu, Ling Li, Huai Yu, Bo Yu, Zhenjuan Zhao, Xueqin Gao
OBJECTIVE: The association between type D personality and coronary plaque vulnerability has been suggested. The objective of the study was to evaluate the potential mediating effects of health behavior on the association between type D personality and plaque vulnerability in coronary artery disease (CAD) patients. METHODS: A total of 319 CAD patients were assessed for type D personality and health behavior via self-administered questionnaires. The plaque vulnerability, evaluated according to characteristics, accompaniment, and outcomes of plaque, was assessed by optical coherence tomography...
May 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29576586/local-flow-patterns-after-implantation-of-bioresorbable-vascular-scaffold-in-coronary-bifurcations-novel-findings-by-computational-fluid-dynamics
#13
Yingguang Li, Zehang Li, Emil N Holck, Bo Xu, Antonios Karanasos, Zhenyu Fei, Yunxiao Chang, Miao Chu, Jouke Dijkstra, Evald H Christiansen, Johan H C Reiber, Niels R Holm, Shengxian Tu
BACKGROUND: Development of methods for accurate reconstruction of bioresorbable scaffolds (BRS) and assessing local hemodynamics is crucial for investigation of vascular healing after BRS implantation.Methods and Results:Patients with BRS that crossed over in a coronary bifurcation were included for analysis. Reconstructions of the coronary lumen and BRS were performed by fusion of optical coherence tomography and coronary angiography generating a tree model (TM) and a hybrid model with BRS (TM-BRS)...
March 24, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29572319/ossabaw-pigs-with-a-pcsk9-gain-of-function-mutation-develop-accelerated-coronary-atherosclerotic-lesions-a-novel-model-for-preclinical-studies
#14
Fang Yuan, Liang Guo, Kyoung-Ha Park, John R Woollard, Kwon Taek-Geun, Kai Jiang, Tamene Melkamu, Bin Zang, Samantha L Smith, Scott C Fahrenkrug, Frank D Kolodgie, Amir Lerman, Renu Virmani, Lilach O Lerman, Daniel F Carlson
BACKGROUND: Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic Ossabaw swine expressing chimp PCSK9 (proprotein convertase subtilisin-like/kexin type 9) containing the D374Y gain of function would develop familial hypercholesterolemia and coronary artery plaques more rapidly than Landrace swine with the same transgene. METHODS AND RESULTS: Ossabaw and Landrace PCSK9 gain-of-function founders were generated by Sleeping Beauty transposition and cloning...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29568764/correlation-of-serum-uric-acid-levels-with-nonculprit-plaque-instability-in-patients-with-acute-coronary-syndromes-a-3-vessel-optical-coherence-tomography-study
#15
Donghui Zhang, Ruoxi Zhang, Ning Wang, Lin Lin, Bo Yu
Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS). However, the correlation between SUA level and coronary plaque instability has not been fully evaluated. The aim of this study was to investigate the association between SUA level and plaque instability of nonculprit lesions in patients with ACS using optical coherence tomography. A total of 150 patients with ACS who underwent 3-vessel optical coherence tomography were selected. Patients were classified into 3 groups according to tertiles of SUA level...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29568146/voxel-based-plaque-classification-in-coronary-intravascular-optical-coherence-tomography-images-using-decision-trees
#16
Chaitanya Kolluru, David Prabhu, Yazan Gharaibeh, Hao Wu, David L Wilson
Intravascular Optical Coherence Tomography (IVOCT) is a high contrast, 3D microscopic imaging technique that can be used to assess atherosclerosis and guide stent interventions. Despite its advantages, IVOCT image interpretation is challenging and time consuming with over 500 image frames generated in a single pullback volume. We have developed a method to classify voxel plaque types in IVOCT images using machine learning. To train and test the classifier, we have used our unique database of labeled cadaver vessel IVOCT images accurately registered to gold standard cryo-images...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29563385/contribution-of-poststent-irregular-protrusion-to-subsequent-in-stent-neoatherosclerosis-after-the-second-generation-drug-eluting-stent-implantation
#17
Yoshinori Sanuki, Shinjo Sonoda, Yoshitaka Muraoka, Akiyoshi Shimizu, Megumi Kitagawa, Hironori Takami, Reo Anai, Tetsu Miyamoto, Yasushi Oginosawa, Yuki Tsuda, Masaru Araki, Yutaka Otsuji
Previous optical coherence tomography (OCT) study reported that irregular protrusion (IP) post drug-eluting stent (DES) implantation was an independent predictor of clinical outcome; however, the relationship between IP and the presence of subsequent in-stent neoatherosclerosis remains unclear. This study aimed to assess the relationship between IP and in-stent neoatheroscrerosis formation using OCT. We evaluated 83 patients (101 lesions) who underwent second-generation DES implantation and 8-month follow-up (8M-FU) using OCT...
March 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29561847/macrophage-polarization-and-acceleration-of-atherosclerotic-plaques-in-a-swine-model
#18
Seul-Gee Lee, Jaewon Oh, Sung-Kyung Bong, Jung-Sun Kim, Seil Park, Sehoon Kim, Sungha Park, Sang-Hak Lee, Yangsoo Jang
AIMS: Atherosclerosis is a well-known cause of cardiovascular disease and is associated with a variety of inflammatory reactions. However, an adequate large-animal model of advanced plaques to investigate the pathophysiology of atherosclerosis is lacking. Therefore, we developed and assessed a swine model of advanced atherosclerotic plaques with macrophage polarization. METHODS: Mini-pigs were fed a 2% high-cholesterol diet for 7 weeks followed by withdrawal periods of 4 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29556525/mobilization-of-progenitor-cells-and-assessment-of-vessel-healing-after-second-generation-drug-eluting-stenting-by-optical-coherence-tomography
#19
Masashi Sakuma, Takahisa Nasuno, Shichiro Abe, Syotaro Obi, Shigeru Toyoda, Isao Taguchi, Ryoichi Sohma, Ken-Ichi Inoue, Setsu Nishino, Koichi Node, Guiherme Attizzani, Hiram Bezerra, Marco Costa, Daniel Simon, Teruo Inoue
Background: Bone marrow-derived progenitor cells likely contribute to both endothelial- and smooth muscle cell-dependent healing responses in stent-injured vessel sites. This study aimed to assess mobilization of progenitor cells and vessel healing after zotarolimus-eluting (ZES) and everolimus-eluting (EES) stents. Methods and results: In 63 patients undergoing coronary stent implantation, we measured circulating CD34 + CD133 + CD45low cells and serum levels of biomarkers relevant to stem cell mobilization...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29553940/benefit-of-a-new-provisional-stenting-strategy-the-re-proximal-optimizing-technique-the-repot-clinical-study
#20
François Dérimay, Gérard Finet, Geraud Souteyrand, Luc Maillard, Adel Aminian, Benoit Lattuca, Guillaume Cayla, Guillaume Cellier, Pascal Motreff, Gilles Rioufol
AIMS: A new coronary bifurcation provisional stenting technique without kissing balloon, rePOT, associating proximal optimizing technique (POT), side-branch inflation and final POT, showed excellent mechanical results in a bench test. The present study sought to use optical coherence tomography (OCT) to quantify the mechanical results of rePOT in vivo in a large patient sample with complex coronary bifurcations. METHODS AND RESULTS: 106 patients with coronary bifurcations were included in a multicenter prospective registry (left main, 40...
March 20, 2018: EuroIntervention
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