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Coronary Optical Coherence Tomography

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https://www.readbyqxmd.com/read/29908828/the-clinical-significance-of-echo-attenuated-plaque-in-stable-angina-pectoris-compared-with-acute-coronary-syndromes-a-combined-intravascular-ultrasound-and-optical-coherence-tomography-study
#1
Shigeki Kimura, Tomoyo Sugiyama, Keiichi Hishikari, Shun Nakagama, Shun Nakamura, Toru Misawa, Masafumi Mizusawa, Kazuto Hayasaka, Yosuke Yamakami, Yuichiro Sagawa, Keisuke Kojima, Hirofumi Ohtani, Hiroyuki Hikita, Atsushi Takahashi
BACKGROUND: Echo-attenuated plaque (EA) on intravascular ultrasound (IVUS) is related to poor outcomes after percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients. However, the clinical significance of EA in stable angina pectoris (SAP) patients compared with that in ACS patients remains unclear. We assessed the relationships between EA and unstable plaque characteristics in patients with ACS and SAP. METHODS: We investigated 609 coronary lesions in 609 patients (234 with ACS; 375 with SAP) undergoing pre-intervention IVUS and optical coherence tomography (OCT)...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29907160/non-culprit-plaque-characteristics-in-acute-coronary-syndrome-patients-with-raised-hemoglobina1c-an-intravascular-optical-coherence-tomography-study
#2
Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun, Bo Yu
BACKGROUND: Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in acute coronary syndrome (ACS) patients remain largely unknown. METHODS: A total of 305 non-culprit plaques from 216 ACS patients were analyzed by intravascular optical coherence tomography. These patients were divided into three groups according to the serum glycosylated hemoglobin level: normal HbA1c (< 5...
June 15, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29901444/establishment-of-healing-profile-and-neointimal-transformation-in-the-new-polymer-free-biolimus-a9-coated-coronary-stent-by-longitudinal-sequential-optical-coherence-tomography-assessments-the-ego-biofreedom-study
#3
Stephen Wai Luen Lee, Frankie C C Tam, Kelvin K W Chan, Simon C C Lam, Shun-Ling Kong, Catherine P Shea, Michael K L Wong, Anthony Y T Wong, Arthur S Y Yung, Li-Wei Zhang, Yui-Ming Lam, Gary S Mintz, Ricardo A Costa, Hans-Peter Stoll, Akiko Maehara
AIMS: In patients at high bleeding risk treated with 1 month of dual antiplatelet therapy, the polymer-free, biolimus A9-coated BioFreedom stent (BFS) was found safer and more efficacious than bare metal stents. We used sequential optical coherence tomography (OCT) to assess the time course of strut coverage and neointimal transformation from 1 to 9 months. METHODS AND RESULTS: We randomly assigned 104 BFS recipients to 1 of 5 groups with angiography and OCT follow-up at 1, 2, 3, 4, or 5 months, together with another follow-up for all at 9 months...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29901443/device-specificity-of-vascular-healing-following-implantation-of-bioresorbable-vascular-scaffolds-and-bioabsorbable-polymer-metallic-drugeluting-stents-in-human-coronary-arteries-the-estrofa-oct-bvs-vs-bp-des-study
#4
Jose Maria de la Torre Hernandez, Nieves Gonzalo, Imanol Otaegui, Jose R Rumoroso, Hipólito Gutiérrez, Fernando Alfonso, Gerard Marti, Ana Serrador Frutos, Salvatore Brugaletta, Antonio Gomez Menchero, Tamara Garcia Camarero, Corina Biagioni, Javier Escaned
AIMS: We sought to compare vascular healing with bioresorbable everolimus-eluting vascular scaffolds (BVS) and drug-eluting stents with bioabsorbable polymers (BP-DES) at 6 and 12 months implanted both in same patients. METHODS AND RESULTS: Multicenter and prospective study including patients with at least two comparable lesions to treat. In every patient both BVS and BP-DES (Synergy™, Orsiro™ or Biomatrix Flex™) were implanted by lesion randomization. Patients included were evaluated with optical coherence tomography at 6 or 12 months (2:1)...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29901442/a-novel-experimental-thrombotic-myocardial-infarction-and-primary-angioplasty-model-in-swine
#5
Georgios Sideris, Nikolaos Magkoutis, Sebastian Voicu, Chantal Kang, Michel Bonneau, Demetris Yannopoulos, Claire Bal Dit Sollier, Jean-Guillaume Dillinger, Natacha Berge, Philippe Brouland, Patrick Henry, Ludovic Drouet
AIMS: We sought to develop a reproducible animal model for acute myocardial infarction (AMI) in adult atherosclerosis-prone pigs. METHODS AND RESULTS: A coil was placed in the right coronary artery or the left anterior descending artery in 26 downsized spontaneously hypercholesterolemic pigs and left untreated until thrombotic occlusion. Then, we crossed the thrombotic occlusion with a guidewire, followed by pre-dilatation, thrombus visualization with Optical Coherence Tomography (OCT) imaging and, finally, deployment of a stent and repeated OCT...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29901441/optical-coherence-tomography-substudy-of-a-prospective-multicenter-randomized-post-market-trial-to-assess-the-safety-and-effectiveness-of-the-firehawk%C3%A2-rapamycin-target-eluting-cobalt-chromium-coronary-stent-system-for-the-treatment-of-atherosclerotic-lesions
#6
Andreas Baumbach, Alexandra J Lansky, Yoshi Onuma, Taku Asano, Thomas Johnson, Richard Anderson, Ferdinand Kiemeneij, Ming Zheng, Niels Van Royen, Ton Slagboom, Georg Vlachojannis, Bo Xu, Patrick Serruys, William Wijns
AIMS: Durable polymer drug-eluting stents (DP DES) may contribute to persistent inflammation, delayed endothelial healing and subsequent late DES thrombosis. The aim of this Optical Coherence Tomography (OCT) sub-study was to compare healing and neointimal coverage of a novel bioabsorbable polymer sirolimus-eluting stent (FIREHAWK®) (BP DES) versus the DP DES (XIENCE) at 90 days in an all comers patient population. METHODS AND RESULTS: The TARGET All Comers study is a prospective multicenter randomised post-market trial of 1656 patients randomised 1:1 to FIREHAWK or XIENCE at 21 centers in 10 European countries...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29900190/data-on-impact-of-monocytes-and-glucose-fluctuation-on-plaque-vulnerability-in-patients-with-coronary-artery-disease
#7
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
Data presented in this article are supplementary material to our research article entitled "Impact of CD14++ CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients" [1]. This article contains the data of study population, diagnostic ability of CD14++ CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899175/atherosclerotic-coronary-plaque-development-visualized-by-in-vivo-coronary-imaging
#8
Kenji Sakamoto, Suguru Nagamatsu, Eiichiro Yamamoto, Koichi Kaikita, Kenichi Tsujita
In the past decades, coronary imaging has evolved as a valuable adjunct to angiography, providing scientific insights into vascular biology and practical guidance by direct visualization of atherosclerosis and other pathologic conditions within the vessel walls. Especially with intravascular ultrasound (IVUS), the signal is able to penetrate below the luminal surface, so the entire cross-section of an artery, including the complete thickness of the plaque, can be imaged in real-time. On the other hand, optical coherence tomography (OCT) has been offering higher image resolution of both the plaque and the luminal surface...
June 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29898865/angioscopic-differences-of-coronary-intima-between-diffuse-and-focal-coronary-vasospasm-comparison-of-optical-coherence-tomography-findings
#9
Daisuke Kitano, Tadateru Takayama, Mitsumasa Sudo, Takaaki Kogo, Keisuke Kojima, Naotaka Akutsu, Toshihiko Nishida, Hironori Haruta, Daisuke Fukamachi, Taro Kawano, Takashi Kanai, Takafumi Hiro, Satoshi Saito, Atsushi Hirayma
BACKGROUND: Coronary artery vasospasm (CS) can be identified as either a diffuse type or focal type; however, the difference in endothelial characteristics between these spasm types remains unclear. The features of coronary intima associated with diffuse spasm and focal spasm using coronary angioscopy (CAS) were evaluated and the optical coherence tomography (OCT) findings were compared. METHODS: CAS and/or OCT observational analysis was performed in 55 patients (mean age: 61...
June 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29859471/in-vivo-optical-coherence-tomography-imaging-and-histopathology-of-healed-coronary-plaques
#10
Aiko Shimokado, Yoshiki Matsuo, Takashi Kubo, Tsuyoshi Nishiguchi, Akira Taruya, Ikuko Teraguchi, Yasutsugu Shiono, Makoto Orii, Takashi Tanimoto, Takashi Yamano, Yasushi Ino, Takeshi Hozumi, Atsushi Tanaka, Yasuteru Muragaki, Takashi Akasaka
BACKGROUND AND AIMS: The aim of this study was to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo, and to evaluate the prevalence and characteristics of HCPs in vivo. METHODS: Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with ≥50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT for HCPs (OCT-derived HCPs); the remaining 114 pairs were used to evaluate the accuracy of OCT in detecting histologically-defined HCPs...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29858960/a-review-in-enormity-of-oct-and-its-enduring-understanding-of-vulnerable-plaque-in-coronary-bifurcation-lesion
#11
REVIEW
Rajiv Shrestha, Aanchal Shrestha, Jing Kan, Shaoliang Chen
Optical coherence tomography (OCT) has emerged as one of the most promising tools to assist the optimization of percutaneous coronary intervention (PCI). Its ability to provide unique information on the plaque at high risk for rupture, plaque composition, the thickness of the fibrous cap, the presence of macrophage and thrombi has not only assisted simple PCI but also in many complex bifurcation lesions PCI. OCT has helped to provide valuable anatomic information to optimize stent implantation and adapt PCI strategy in individual patients...
June 1, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29850411/very-late-bare-metal-stent-thrombosis-in-the-setting-of-discontinuation-of-optimal-medical-therapy-for-2-years
#12
Kota Murai, Kenji Sakata, Tomohito Mabuchi, Masato Yamaguchi, Masayuki Mori, Kenshi Hayashi, Masa-Aki Kawashiri
A 52-year-old man was admitted to our hospital because of acute anteroseptal myocardial infarction. After a bare metal stent (BMS) was implanted in the left anterior descending artery (LAD), aspirin, clopidogrel, statin, angiotensin II receptor blocker, and β blocker were prescribed. 6 years later, however, the patient stopped taking all medication by himself. Further 2 years later, the patient was admitted to our hospital again with chest pain, and emergent coronary angiography showed the total occlusion of the LAD at the site where the previous stent was deployed...
April 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29849660/seizure-associated-st-elevation-myocardial-infarction-in-absence-of-plaque-rupture
#13
Haytham Mously, Mohammed Wazzan, Ahmed Z Alkhathlan, Indiresha Iyer
Acute coronary syndrome (ACS) is a very common cause of morbidity and mortality in the U.S. Here, we present a case of acute ST elevation myocardial infarction (STEMI) in the setting of seizure activity. In this rare case, we have data from optical coherence tomography (OCT) that showed no plaque disruption, showing the role of OCT in understanding the pathophysiology of STEMI and providing some ideas for the mechanism of this seizure-induced STEMI.
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29848333/numerical-analysis-of-the-pressure-drop-across-highly-eccentric-coronary-stenoses-application-to-the-calculation-of-the-fractional-flow-reserve
#14
R Agujetas, M R González-Fernández, J M Nogales-Asensio, J M Montanero
BACKGROUND: Fractional flow reverse (FFR) is the gold standard assessment of the hemodynamic significance of coronary stenoses. However, it requires the catheterization of the coronary artery to determine the pressure waveforms proximal and distal to the stenosis. On the contrary, computational fluid dynamics enables the calculation of the FFR value from relatively non-invasive computed tomography angiography (CTA). METHODS: We analyze the flow across idealized highly-eccentric coronary stenoses by solving the Navier-Stokes equations...
May 30, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29805111/long-term-coronary-functional-assessment-of-the-infarct-related-artery-treated-with-everolimus-eluting-bioresorbable-scaffolds-or-everolimus-eluting-metallic-stents-insights-of-the-trofi-ii-trial
#15
Josep Gomez-Lara, Salvatore Brugaletta, Luis Ortega-Paz, Bert Vandeloo, Elisabetta Moscarella, Miguel Salas, Rafael Romaguera, Gerard Roura, José L Ferreiro, Luis Teruel, Montserrat Gracida, Stephan Windecker, Patrick W Serruys, Joan-Antoni Gomez-Hospital, Manel Sabaté, Angel Cequier
OBJECTIVES: The study sought to compare the vasomotor and microcirculatory function of the infarct-related artery (IRA) between bioresorbable vascular scaffolds (BVS) and everolimus-eluting stents (EES) at 3 years. BACKGROUND: The ABSORB STEMI TROFI II study showed similar outcomes between BVS and EES in the context of ST-segment elevation myocardial infarction at 3 years. METHODS: Sixty-three consecutive event-free patients of the randomized TROFI II study were screened to undergo coronary angiography with vasomotor, microcirculatory, and optical coherence tomography (OCT) examination at 3 years...
May 17, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29804698/in-vivo-tissue-characterization-of-human-atherosclerotic-plaques-by-optical-coherence-tomography-a-directional-coronary-atherectomy-study-with-histopathologic-confirmation
#16
Maoto Habara, Fumiyuki Otsuka, Etsuo Tsuchikane, Mitsuyasu Terashima, Kenya Nasu, Yoshihisa Kinoshita, Akira Murata, Yoriyasu Suzuki, Yoshiaki Kawase, Munenori Okubo, Hitoshi Matsuo, Tetsuo Matsubara, Satoshi Yasuda, Hatsue Ishibashi-Ueda, Takahiko Suzuki
BACKGROUND: The histopathological validation of optical coherence tomography (OCT) in visualizing atherosclerotic plaques has been reported only in ex vivo studies. We sought to evaluate the accuracy of OCT in tissue characterization in vivo. METHODS AND RESULTS: A total of 25 patients with stable angina pectoris who underwent directional coronary atherectomy (DCA) were included in the investigation, whereby OCT was performed before and after a single debulking...
May 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29794389/exacerbated-peri-stent-contrast-staining-on-serial-angiography-and-optical-coherence-tomography-after-platinum-chromium-everolimus-eluting-stent-implantation-for-infrapopliteal-artery-lesions
#17
Yusuke Tomoi, Shoichi Kuramitsu, Yoshimitsu Soga, Seiichi Hiramori, Kenji Ando
Unlike coronary arteries, little is known about peri-stent contrast staining (PSS) formation after drug-eluting stent (DES) implantation for infrapopliteal arteries. Herein, we report exacerbated PSS assessed by serial angiography and optical coherence tomography (OCT) after platinum-chromium everolimus-eluting stent (PtCr-EES) implantation for infrapopliteal artery lesions. A 68-year-old women with recurrent left critical limb ischemia was admitted to our hospital. Standard endovascular techniques were performed for the popliteal artery (POP) and tibioperoneal trunk (TPT), but residual stenosis occurred...
May 23, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29790954/clinical-use-of-intracoronary-imaging-part-1-guidance-and-optimization-of-coronary-interventions-an-expert-consensus-document-of-the-european-association-of-percutaneous-cardiovascular-interventions-endorsed-by-the-chinese-society-of-cardiology
#18
Lorenz Räber, Gary S Mintz, Konstantinos C Koskinas, Thomas W Johnson, Niels R Holm, Yoshinubo Onuma, Maria D Radu, Michael Joner, Bo Yu, Haibo Jia, Nicolas Menevau, Jose M de la Torre Hernandez, Javier Escaned, Jonathan Hill, Francesco Prati, Antonio Colombo, Carlo di Mario, Evelyn Regar, Davide Capodanno, William Wijns, Robert A Byrne, Giulio Guagliumi
This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified...
May 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29790037/one-year-optical-coherence-tomography-findings-in-patients-with-late-and-very-late-stent-thrombosis-treated-with-intravascular-imaging-guided-percutaneous-coronary-intervention
#19
Marcos Ñato, Josep Gomez-Lara, Rafael Romaguera, Gerard Roura, José Luis Ferreiro, Luis Teruel, Montserrat Gracida, Lara Fuentes, Bert Vandeloo, Joan-Antoni Gomez-Hospital, Angel Cequier
Patients with late/very-late stent thrombosis (ST) are at high risk of recurrent-ST. The mechanisms of recurrent-ST are largely unknown. The objective is to describe the 1-year optical coherence tomography (OCT) findings of patients suffering from late/very-late ST treated with intravascular imaging guided percutaneous coronary intervention (PCI). All consecutive patients with late/very-late ST undergoing intravascular imaging guided PCI were screened to undergo coronary angiography and OCT examination at 1 year...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29788263/temporal-course-of-vascular-healing-and-neoatherosclerosis-after-implantation-of-durable-or-biodegradable-polymer-drug-eluting-stents
#20
Giulio Guagliumi, Kunihiro Shimamura, Vasile Sirbu, Roberto Garbo, Giacomo Boccuzzi, Angelina Vassileva, Orazio Valsecchi, Luigi Fiocca, Paolo Canova, Francesco Colombo, Gabriel Tensol Rodriguez Pereira, Daisuke Nakamura, Guilherme F Attizzani, Alberto Cereda, Keisuke Satogami, Leonardo De Luca, Francesco Saia, Davide Capodanno
Aims: Delayed healing and endothelial dysfunction may occur with drug-eluting stents (DES), promoting accelerated infiltration of lipids in the neointima and development of neoatherosclerosis (NA). Pathology data suggest durable polymer (DP) of DES to play a major role in this process. Whether biodegradable polymer (BP) may address these issues is uncertain. We compared in vivo vessel healing and NA of current generation BP- or DP-DES using serial optical coherence tomography (OCT) assessments...
May 19, 2018: European Heart Journal
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