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Coronary Optical Coherence Tomography

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https://www.readbyqxmd.com/read/27896843/impact-of-clinical-presentation-on-early-vascular-healing-after-bioresorbable-vascular-scaffold-implantation
#1
Moritz Baquet, Christoph Brenner, Maximilian Wenzler, Madeleine Eickhoff, Jochheim David, Stefan Brunner, Hans Theiss, Steffen Massberg, Giulio Guagliumi, Julinda Mehilli
BACKGROUND: Optimal strut coverage and early vascular healing are important factors to reduce the risk of stent thrombosis. Data on early vascular healing with the new bioresorbable vascular scaffolds (BVS) are lacking. Further, healing response after BVS implantation in different clinical presentation has not been fully investigated. METHODS AND RESULTS: We assessed with optical coherence tomography (OCT) the early vascular response to BVS implantation in 26 consecutive patients presenting with acute coronary syndrome (ACS) or stable angina (SA)...
November 28, 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27896495/accuracy-of-coronary-computed-tomography-angiography-for-bioresorbable-scaffold-luminal-investigation-a-comparison-with-optical-coherence-tomography
#2
Carlos Collet, Yohei Sotomi, Rafael Cavalcante, Taku Asano, Yosuke Miyazaki, Erhan Tenekecioglu, Pieter Kistlaar, Yaping Zeng, Pannipa Suwanasson, Robbert J de Winter, Koen Nieman, Patrick W Serruys, Yoshinobu Onuma
To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed...
November 28, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27894264/optical-coherence-tomography-findings-after-longitudinal-ablation-for-an-underexpanded-stent-in-a-heavily-calcified-lesion-a-case-report
#3
Masahiro Koide, Keiji Inoue, Akiko Matsuo, Hiroshi Fujita
BACKGROUND: Heavy coronary artery calcification is responsible for stent underexpansion, which is associated with increased in-stent restenosis. Here we report a case in which optical coherence tomography (OCT) demonstrated that the metal component of an underexpanded stent previously implanted in a heavy calcified lesion had been completely removed after ablation with rotational atherectomy. CASE PRESENTATION: An 83-year-old man with exertional angina was referred to our hospital...
November 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27885511/does-anticoagulation-therapy-prevent-thrombosis-in-coronary-stent-grafts
#4
Yuki Honda, Kohei Wakabayashi, Takayasu Suzuki, Hiroshi Suzuki
A polytetrafluoroethylene (PTFE)-covered stent was deployed for enlarging coronary aneurysms in a 73-year-old man. Optical coherence tomography (OCT) and coronary angioscopy performed 3 months later revealed naked stent struts and thin patches of red thrombi covering the PTFE membrane even under dual antiplatelet therapy (DAPT). After 5-month warfarin administration under DAPT, OCT and angioscopy showed a clear extinction of the thin patches of red thrombi on the PTFE membrane and stent struts, although most of the struts were still naked...
November 24, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27884129/in-vivo-optical-coherence-tomography-visualization-of-intraplaque-neovascularization-at-the-site-of-coronary-vasospasm-a-case-report
#5
Kenichi Tsujita, Koichi Kaikita, Satoshi Araki, Toshihiro Yamada, Suguru Nagamatsu, Kenshi Yamanaga, Kenji Sakamoto, Sunao Kojima, Seiji Hokimoto, Hisao Ogawa
BACKGROUND: Coronary plaques in patients with coronary vasospastic angina have been characterized by diffuse intima-media thickening with homogeneous fibrous tissue, without confluent necrotic tissue. However, coronary vasospasm can trigger coronary thrombosis, and may play an important role in the pathogenesis of acute coronary syndromes, though the precise morphological mechanisms underlying this process remain unclear. CASE PRESENTATION: A 43-year-old man with a history of multivessel coronary vasospastic angina had been treated with long-acting diltiazem and fluvastatin since 2004...
November 25, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27879518/three-month-evaluation-of-strut-healing-using-a-novel-optical-coherence-tomography-analytical-method-following-bioresorbable-polymer-everolimus-eluting-stent-implantation-in-humans-the-timeless-study
#6
Boris Vesga, Hector Hernandez, Miguel Moncada, Pawel Gasior, Sergio A H Leal, Antonio Dager, Camilo Arana, Juan A Delgado, Philippe Généreux, Akiko Maehara, Juan F Granada
AIMS: Bioresorbable polymer drug-eluting stent technologies have been considered to have the potential to enhance vascular healing by reducing polymer exposure to the vessel wall, potentially allowing the earlier discontinuation of dual antiplatelet therapy. At present, the early vascular healing response to this type of technologies is still unclear. PATIENTS AND METHODS: The TIMELESS study is a multicenter, prospective, single-arm study that enrolled real-world patients undergoing percutaneous coronary intervention...
November 22, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27871242/comparison-of-coronary-arterial-lumen-dimensions-on-angiography-and-plaque-characteristics-on-optical-coherence-tomography-images-and-their-changes-induced-by-statin
#7
Nana Dong, Zulong Xie, Wei Wang, Jiannan Dai, Meng Sun, Zhongyue Pu, Jinwei Tian, Bo Yu
BACKGROUND: Coronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence tomography (OCT) is used to evaluate the characteristics of atherosclerotic plaque. This study was aimed to compare coronary lumen dimensions using CAG and plaque characteristics using OCT and their changes during statin therapy. METHODS: We identified 97 lipid-rich plaques from 69 statin-naïve patients, who received statin therapy in the following 12 months...
November 22, 2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27867716/automatic-classification-of-atherosclerotic-plaques-imaged-with-intravascular-oct
#8
Jose J Rico-Jimenez, Daniel U Campos-Delgado, Martin Villiger, Kenichiro Otsuka, Brett E Bouma, Javier A Jo
Intravascular optical coherence tomography (IV-OCT) allows evaluation of atherosclerotic plaques; however, plaque characterization is performed by visual assessment and requires a trained expert for interpretation of the large data sets. Here, we present a novel computational method for automated IV-OCT plaque characterization. This method is based on the modeling of each A-line of an IV-OCT data set as a linear combination of a number of depth profiles. After estimating these depth profiles by means of an alternating least square optimization strategy, they are automatically classified to predefined tissue types based on their morphological characteristics...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27866137/clinical-and-multimodality-imaging-results-at-6-months-of-a-bioresorbable-sirolimus-eluting-scaffold-for-patients-with-single-de-novo-coronary-artery-lesions-the-neovas-first-in-man-trial
#9
Yao-Jun Zhang, Xiao-Zeng Wang, Guosheng Fu, Quan-Min Jing, Geng Wang, Chong-Ying Jin, Li-Hua Xie, Jin-Zan Cai, Bo Xu, Ya-Ling Han
AIMS: The study sought to investigate clinical and multimodality imaging assessment of a bioresorbable sirolimus-eluting scaffold (NeoVas, Lepu Medical, Beijing, China) for patients with single de novo coronary artery lesions. METHODS AND RESULTS: The NeoVas first-in-man study was a prospective, open-label study which enrolled 31 patients with single de novo lesions treated with a bioresorbable sirolimus-eluting scaffold. The primary endpoint was target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction and clinically indicated target lesion revascularisation (TLR)...
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27866017/safety-of-optical-coherence-tomography-in-pediatric-heart-transplant-patients
#10
Sarah M Ulrich, Anja Lehner, Julia Birnbaum, Stefanie Heckel, Nikolaus A Haas, Lale Hakami, Rene Schramm, Robert Dalla Pozza, Marcus Fischer, Rainer Kozlik-Feldmann
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a crucial problem after heart transplantation, in adults as well as in children. CAV is the main risk factor for a reduced long-term graft survival. The early diagnosis and treatment of CAV is essential for a successful long-term preservation of the donor heart. However, asymptomatic progression of CAV and concentric hyperplasia of the coronary arteries may complicate the early diagnosis by conventional measures. Intravascular imaging, such as intravascular ultrasound and optical coherence tomography (OCT), enables the diagnosis of early stage CAV...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27863843/score2-report-2-study-design-and-baseline-characteristics
#11
Ingrid U Scott, Paul C VanVeldhuisen, Michael S Ip, Barbara A Blodi, Neal L Oden, Maria Figueroa, Pravin U Dugel
PURPOSE: To describe the design and baseline characteristics of participants in the Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE2) and to compare with cohorts from other retinal vein occlusion trials. DESIGN: Phase III prospective, multicenter, randomized clinical trial designed to assess whether intravitreal bevacizumab is noninferior to intravitreal aflibercept for treatment of decreased vision attributable to macular edema associated with central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO)...
November 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27863292/mechanical-abnormalities-associated-with-first-and-second-generation-drug-eluting-stent-thrombosis-analyzed-by-optical-coherence-tomography-in-the-national-pesto-french-registry
#12
Nicolas Amabile, Charlotte Trouillet, Nicolas Meneveau, Claire Marie Tissot, Loic Belle, Nicolas Combaret, Grégoire Range, Michel Pansieri, Regis Delaunay, Sébastien Levesque, Thibault Lhermusier, François Derimay, Pascal Motreff, Christophe Caussin, Géraud Souteyrand
BACKGROUND AND OBJECTIVES: DES thrombosis may be triggered by different mechanisms that are difficult to identify by angiography alone. This work aimed to investigate and compare the characteristics of stent thrombosis (ST) between 1st- and 2nd-generation drug-eluting stents (DES) among a large cohort of patients explored by optical coherence tomography (OCT). METHODS AND RESULTS: The PESTO study was a prospective national registry involving 29 French catheterization facilities...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27862314/impact-of-diabetes-mellitus-on-intravascular-ultrasound-guided-provisional-stenting-in-coronary-bifurcation-lesions-j-reverse-sub-study
#13
Masahiro Yamawaki, Daisuke Terashita, Hachidai Takahashi, Toshiro Shinke, Kenichi Fujii, Yoshihisa Shimada, Yoshihiro Takeda, Shinichiro Yamada, Yoshihisa Kinoshita, Yoshinobu Murasato
OBJECTIVE: To investigate the impact of diabetes mellitus (DM) on provisional coronary bifurcation stenting under the complete guidance of intravascular-ultrasound (IVUS). BACKGROUND: The efficacy of such intervention has not yet been fully elucidated in the DM patients. METHODS: A total of 100 DM and 139 non-DM patients in a prospective multi-center registry of IVUS-guided bifurcation stenting were compared in angiographic results at 9 months...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27846629/assessment-of-a-drug-eluting-balloon-for-the-treatment-of-de-novo-coronary-lesions-guided-by-optical-coherence-tomography-study-protocol-for-a-randomized-controlled-trial
#14
Bo Li, Yu Ding, Feng Tian, Weiren Chen, Tianwen Han, Yundai Chen
BACKGROUND: The drug-eluting balloon (DEB) is a promising tool to prevent restenosis after coronary angioplasty. However, data on the outcomes of DEB in de novo lesions are scarce. Vessel recoil and constrictive remodeling are the dominant causes of restenosis after angioplasty. The use of cutting balloons (CB) may effectively reduce elastic recoil after balloon dilation. In this study, we evaluate the efficacy and safety of DEB in treating de novo coronary artery lesions, using a predilation strategy with cutting balloon (CB) dilation before DEB angioplasty...
November 16, 2016: Cardiology
https://www.readbyqxmd.com/read/27836501/evaluation-of-a-framework-for-the-co-registration-of-intravascular-ultrasound-and-optical-coherence-tomography-coronary-artery-pullbacks
#15
David S Molony, Lucas H Timmins, Emad Rasoul-Arzrumly, Habib Samady, Don P Giddens
A growing number of studies have used a combination of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for the assessment of atherosclerotic plaques. Given their respective strengths these imaging modalities highly complement each other. Correlations of hemodynamics and coronary artery disease (CAD) have been extensively investigated with both modalities separately, though not concurrently due to challenges in image registration. Manual co-registration of these modalities is a time expensive task subject to human error, and the development of an automatic method has not been previously addressed...
October 28, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27832420/disruption-of-bioresorbable-vascular-scaffold-struts-due-to-loss-of-radial-integrity-insights-from-optical-coherence-tomography
#16
Ana Rita Ramalho, João Silva Marques, Guilherme Mariano Pêgo
Strut disruption of bioresorbable vascular scaffold is a known potential concern, although uncommon when adequate lesion preparation is achieved and nominal size of the scaffold is respected. It is usually difficult to detect with angiography and/or intravascular ultrasound. Three-dimensional reconstructions of optical coherence tomography facilitates understanding of complex luminal anatomy and configuration of stent struts, providing evaluation of stent integrity immediately after deployment and therefore optimization of the complex revascularization procedure...
November 10, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27830336/optical-coherence-tomography-influence-of-contrast-concentration-on-image-quality-and-diagnostic-confidence
#17
Florian Blachutzik, Stephan Achenbach, Holger Nef, Christian Hamm, Oliver Dörr, Niklas Boeder, Mohamed Marwan, Monique Tröbs, Reinhard Schneider, Jens Röther, Christian Schlundt
OCT requires intracoronary injection of contrast agent to remove blood from the coronary lumen during data acquisition, which is a possible limitation of this method. Aim of this study was to analyze the influence of iodine concentration on image quality and diagnostic certainty of optical coherence tomography (OCT). OCT sequences acquired using contrast agent with a reduced concentration of 150 mg iodine/ml and a standard concentration of 350 mg iodine/ml were analyzed. Cross-sectional images with a spacing of 10 mm were evaluated regarding image quality and diagnostic confidence...
November 9, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27824620/progression-of-a-lesion-with-nodular-calcification-serial-observations-by-optical-coherence-tomography-and-coronary-angioscopy
#18
Shigeki Kimura, Yuichiro Sagawa, Tomoyo Sugiyama, Keiichi Hishikari, Shun Nakamura, Shun Nakagama, Toru Misawa, Masafumi Mizusawa, Kazuto Hayasaka, Yosuke Yamakami, Keisuke Kojima, Hirofumi Ohtani, Hiroyuki Hikita, Atsushi Takahashi, Mitsuaki Isobe
No abstract text is available yet for this article.
November 7, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27818479/optical-coherence-tomography-findings-in-early-stent-thrombosis-by-heparin-induced-thrombocytopenia
#19
Hiroshi Okamoto, Teruyoshi Kume, Kenzo Fukuhara, Yusuke Kobayashi, Ai Kawamura, Yutaka Goryo, Terumasa Koyama, Tomoko Tamada, Ryotaro Yamada, Koichiro Imai, Yoji Neishi, Shiro Uemura
A 62-year-old man with a family history of coronary artery disease and a history of smoking, diabetes and dyslipidemia was admitted to our hospital with chest pain from acute myocardial infarction. Emergent coronary angiography was performed with intervention to a mid-right coronary occlusion with drug-eluting stent implantation. Optical coherence tomography (OCT) visualized well-apposed stent struts and no remarkable tissue protrusion, stent underexpansion, malapposition, edge dissection, and hematoma. Immediately after OCT imaging, a coronary angiogram showed a filling defect surrounded by contrast medium at the site of the stented lesion...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27806900/optical-coherence-tomography-compared-with-intravascular-ultrasound-and-with-angiography-to-guide-coronary-stent-implantation-ilumien-iii-optimize-pci-a-randomised-controlled-trial
#20
Ziad A Ali, Akiko Maehara, Philippe Généreux, Richard A Shlofmitz, Franco Fabbiocchi, Tamim M Nazif, Giulio Guagliumi, Perwaiz M Meraj, Fernando Alfonso, Habib Samady, Takashi Akasaka, Eric B Carlson, Massoud A Leesar, Mitsuaki Matsumura, Melek Ozgu Ozan, Gary S Mintz, Ori Ben-Yehuda, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) is most commonly guided by angiography alone. Intravascular ultrasound (IVUS) guidance has been shown to reduce major adverse cardiovascular events (MACE) after PCI, principally by resulting in a larger postprocedure lumen than with angiographic guidance. Optical coherence tomography (OCT) provides higher resolution imaging than does IVUS, although findings from some studies suggest that it might lead to smaller luminal diameters after stent implantation...
November 26, 2016: Lancet
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