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https://www.readbyqxmd.com/read/28335538/precise-orbit-solution-for-swarm-using-space-borne-gps-data-and-optimized-pseudo-stochastic-pulses
#1
Bingbing Zhang, Zhengtao Wang, Lv Zhou, Jiandi Feng, Yaodong Qiu, Fupeng Li
Swarm is a European Space Agency (ESA) project that was launched on 22 November 2013, which consists of three Swarm satellites. Swarm precise orbits are essential to the success of the above project. This study investigates how well Swarm zero-differenced (ZD) reduced-dynamic orbit solutions can be determined using space-borne GPS data and optimized pseudo-stochastic pulses under high ionospheric activity. We choose Swarm space-borne GPS data from 1-25 October 2014, and Swarm reduced-dynamic orbits are obtained...
March 20, 2017: Sensors
https://www.readbyqxmd.com/read/28328097/markers-of-iron-status-in-chronic-kidney-disease
#2
Adam E Gaweda
Anemia is one of the main comorbidities related to chronic kidney disease (CKD). Until the advent of erythropoiesis stimulating agents (ESA), endogenous erythropoietin deficiency has been thought to be the main culprit of anemia in CKD patients. The use of ESAs has shed new light on the physiology of CKD anemia, where iron homeostasis plays an increasingly important role. Disorders of iron homeostasis occurring in CKD turn the anemia management in those patients into a complex multifactorial therapeutic task, where ESA and Iron dose must be properly balanced to achieve the desired outcome without exposing the patients to the risk of serious adverse events...
March 22, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28325880/balancing-selection-maintains-polymorphisms-at-neurogenetic-loci-in-field-experiments
#3
Eija Lonn, Esa Koskela, Tapio Mappes, Mikael Mokkonen, Angela M Sims, Phillip C Watts
Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reproductive behaviors in mammals, including humans. That these genes have important fitness consequences and that natural populations contain extensive diversity at these loci implies the action of balancing selection...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28323091/age-related-differences-in-functional-synchronization-of-eeg-activity-as-evaluated-by-means-of-tms-eeg-coregistrations
#4
Florinda Ferreri, Fabrizio Vecchio, Andrea Guerra, Francesca Miraglia, David Ponzo, Luca Vollero, Giulio Iannello, Sara Maatta, Esa Mervaala, Paolo Maria Rossini, Vincenzo Di Lazzaro
It was recently demonstrated that the characteristics of EEG rhythms preceding a transcranial magnetic stimulation (TMS) of the motor cortex (M1) influence the motor-evoked potential (MEP) amplitude with a peculiar pattern, thus reflecting the M1 functional state. As physiological aging is related to a decrease in motor performance and changes in excitability and connectivity strength within cerebral sensorimotor circuits, we aimed to explore whether aging affects EEG-MEP interactions. Using MRI-navigated TMS and multichannel EEG, we compared the EEG-MEP interactions observed in healthy aged subjects with those observed in young volunteers...
March 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28320343/targets-for-adapting-intravenous-iron-dose-in-hemodialysis-a-proof-of-concept-study
#5
N O Peters, N Jay, J Cridlig, G Rostoker, L Frimat
BACKGROUND: Intravenous iron is widely used to control anemia in dialysis patients and limits costs related to erythropoiesis-stimulating agents (ESA). Current guidelines do not clearly set upper limits for serum ferritin (SF) and transferrin saturation (TSAT). International surveys such as the Dialysis Outcomes and Practice Patterns Study (DOPPS) showed that this lack of upper limits potentially led nephrologists to prescribe iron infusions even for patients with a high SF. Recent publications have suggested a risk of short- and long-term adverse effects related to iron overload...
March 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28320088/flower-extract-of-allium-atroviolaceum-triggered-apoptosis-activated-caspase-3-and-down-regulated-antiapoptotic-bcl-2-gene-in-hela-cancer-cell-line
#6
Somayeh Khazaei, Vasudevan Ramachandran, Roslida Abdul Hamid, Norhaizan Mohd Esa, Ali Etemad, Sara Moradipoor, Patimah Ismail
Cervical cancer accounts for the second most frequent cancer and also third leading cause of cancer mortality (15%) among women worldwide. The major problems of chemotherapeutic treatment in cervical cancer are non-specific cytotoxicity and drug resistance. Plant-derived products, known as natural therapies, have been used for thousands of years in cancer treatment with a very low number of side effects. Allium atroviolaceum is a species in the genus Allium and Liliaceae family, which could prove to have beneficial effects on cancer treatment, although there is a lack of corresponding attention...
March 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28316046/treatment-of-municipal-wastewater-in-full-scale-on-site-sand-filter-reduces-bod-efficiently-but-does-not-reach-requirements-for-nitrogen-and-phosphorus-removal
#7
Petteri Laaksonen, Aki Sinkkonen, Gennadi Zaitsev, Esa Mäkinen, Timo Grönroos, Martin Romantschuk
A traditional sand filter for treatment of household wastewater was constructed in the fall of 2012 at Biolinja 12, Turku, Finland. Construction work was led and monitored by an authorized wastewater treatment consultant. The filter was placed on a field bordered by open ditches from all sides in order to collect excess rain and snowmelt waters. The filter was constructed and insulated from the environment so that all outflowing water was accounted for. Untreated, mainly municipal, wastewater from Varissuo suburb was pumped from a sewer separately via three septic tanks (volume = 1 m(3) each) into the filters...
March 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28301279/integrating-palliative-care-services-in-ambulatory-oncology-an-application-of-the-edmonton-symptom-assessment-system
#8
Sherri L Rauenzahn, Susanne Schmidt, Ifeoma O Aduba, Jessica T Jones, Nazneen Ali, Laura L Tenner
PURPOSE: Research in palliative care demonstrates improvements in overall survival, quality of life, symptom management, and reductions in the cost of care. Despite the American Society of Clinical Oncology recommendation for early concurrent palliative care in patients with advanced cancer and high symptom burden, integrating palliative services is challenging. Our aims were to quantitatively describe the palliative referral rates and symptom burden in a South Texas cancer center and establish a palliative referral system by implementing the Edmonton Symptom Assessment Scale (ESAS)...
March 16, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28301037/primary-care-for-diabetes-mellitus-patients-from-the-perspective-of-the-care-model-for-chronic-conditions
#9
Maria Aparecida Salci, Betina Hörner Schlindwein Meirelles, Denise Maria Guerreiro Vieira da Silva
Objective: to assess the health care Primary Health Care professionals provide to diabetes mellitus patients from the perspective of the Modelo de Atenção às Condições Crônicas. Method: qualitative study, using the theoretical framework of Complex Thinking and the Modelo de Atenção às Condições Crônicas and the methodological framework of assessment research. To collect the data, 38 interviews were held with health professionals and managers; observation of the activities by the health teams; and analysis of 25 files of people who received this care...
March 9, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28300416/correction-to-prediction-of-ocular-drug-distribution-from-systemic-blood-circulation
#10
Kati-Sisko Vellonen, Esa-Matti Soini, Eva M Del Amo, Arto Urtti
No abstract text is available yet for this article.
March 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28300338/chinese-1-strain-of-toxoplasma-gondii-excreted-secreted-antigens-negatively-modulate-foxp3-via-inhibition-of-the-tgf%C3%A3-rii-smad2-smad3-smad4-pathway
#11
Jinling Chen, Caiqun Huang, Dandan Zhu, Pei Shen, Yinong Duan, Jianxin Wang, Chunzhao Yang, Liting Wu
Toxoplasma gondii is an opportunistic intracellular parasite and is considered an important aetiological factor in the process of abortion, especially as occurs in early gestation. Chinese 1 strain of T. gondii is a dominant genotype prevalent in China. Although it is known that early foetal resorption triggered by RH strain of T. gondii is attributable to immune mechanisms rather than its direct effect in uterus, the underlying mechanism of the abortion caused by Chinese 1 strain remains unclear. This study was designed to investigate the effect of excreted-secreted antigens (ESA) of Chinese 1 strain of T...
March 16, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28299946/single-institute-experience-with-methylphenidate-and-american-ginseng-in-cancer-related-fatigue
#12
Young D Chang, Joshua Smith, Diane Portman, Richard Kim, Ritika Oberoi-Jassal, Sahana Rajasekhara, Mellar Davis
BACKGROUND: Single therapy with methylphenidate or American ginseng contributes to the reduction in cancer-related fatigue (CRF) with different pharmacologic mechanisms and is relatively safe. However, the safety and efficacy of treating CRF with methylphenidate and AG combination therapy is unknown. AIM: The primary objective was to assess the clinical safety and the change in fatigue with numerical rating scale (NRS) on the Edmonton Symptom Assessment Scale (ESAS) after intervention with methylphenidate and AG combination therapy...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28298724/variability-of-chlorophyll-a-concentration-in-the-gulf-of-guinea-and-its-relation-to-physical-oceanographic-variables
#13
Karen Nieto, Frédéric Mélin
The Gulf of Guinea represents a wide tract of the African coast with complex and rich coastal ecosystems undergoing various pressures. The seasonal variations of chlorophyll-a concentration (Chla) along the Gulf of Guinea (GoG) and their relations with physical oceanographic variables were analyzed using satellite observations covering the period 2002-2012. The effects of sea surface temperature (SST), sea level anomalies (SLA), winds, geostrophic currents, eddy kinetic energy (EKE), mesoscale eddies and fronts were considered on a monthly time scale...
February 2017: Progress in Oceanography
https://www.readbyqxmd.com/read/28296531/risk-factors-associated-with-acute-kidney-injury-in-a-cohort-of-20-575-arthroplasty-patients
#14
Pyry Jämsä, Esa Jämsen, Leo-Pekka Lyytikäinen, Jarkko Kalliovalkama, Antti Eskelinen, Niku Oksala
Background and purpose - Patients developing postoperative acute kidney injury (AKI) are at risk of higher morbidity and mortality. In arthroplasty patients, many pre- and perioperative factors are associated with AKI but some of the risk factors are unclear. We report the incidence of postoperative AKI, the conditions associated with it, and survival rates in AKI patients. Patients and methods - We obtained data from 20,575 consecutive hip or knee arthroplasties. Postoperative AKI, occurring within 7 days after the operation, was defined using the risk, injury, failure, loss, and end-stage (RIFLE) criteria...
March 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28283577/distinct-roles-of-light-activated-channels-trp-and-trpl-in-photoreceptors-of-periplaneta-americana
#15
Paulus Saari, Andrew S French, Päivi H Torkkeli, Hongxia Liu, Esa-Ville Immonen, Roman V Frolov
Electrophysiological studies in Drosophila melanogaster and Periplaneta americana have found that the receptor current in their microvillar photoreceptors is generated by two light-activated cationic channels, TRP (transient receptor potential) and TRPL (TRP-like), each having distinct properties. However, the relative contribution of the two channel types to sensory information coding by photoreceptors remains unclear. We recently showed that, in contrast to the diurnal Drosophila in which TRP is the principal phototransduction channel, photoreceptors of the nocturnal P...
March 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28283484/comparative-effectiveness-and-safety-of-erythropoiesis-stimulating-agents-biosimilars-vs-originators-in-clinical-practice-a-population-based-cohort-study-in-italy
#16
Francesco Trotta, Valeria Belleudi, Danilo Fusco, Laura Amato, Alessandra Mecozzi, Flavia Mayer, Massimo Sansone, Marina Davoli, Antonio Addis
OBJECTIVES: To evaluate the benefit/risk profile of epoetin α biosimilar with the erythropoiesis-stimulating agents (ESAs) originators when administered to naïve patients from clinical practice. DESIGN: Population-based observational cohort study. SETTING: All residents in the Lazio Region, Italy, with chronic kidney disease (CKD) or cancer retrieved from the Electronic Therapeutic Plan (ETP) Register for ESA between 2012 and 2014. PARTICIPANTS: Overall, 13 470 incident ESA users were available for the analysis, 8161 in the CKD and 5309 in the oncology setting, respectively...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28277851/management-of-lower-risk-myelodysplastic-syndromes-without-del5q-current-approach-and-future-trends
#17
Maximilian Stahl, Amer M Zeidan
Myelodysplastic syndromes (MDS) are characterized by progressive bone marrow failure manifesting as blood cytopenia and a variable risk of progression into acute myeloid leukemia. MDS is heterogeneous in biology and clinical behavior. MDS is generally divided into lower-risk (LR) or higher-risk (HR) MDS. Goals of care in HR-MDS is changing the natural history of the disease, whereas in LR-MDS it is symptom control and quality of life. Areas covered: We review the epidemiology, tools of risk assessment, and the available therapeutic modalities for LR-MDS...
February 21, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28277427/effects-of-sparring-load-on-reaction-speed-and-punch-force-during-the-pre-competition-and-competition-periods-in-boxing
#18
Esa Hukkanen, Keijo Häkkinen
Seven male national team level boxers (age 20.3±2.7 years, height 1.80±0.06 m, mass 73.8±11.1 kg) participated in this study to investigate effects of sparring on reaction time and punch force of straight punches measured during the pre-competition and competition periods. Heart rate and blood lactate concentrations were also monitored. Sparring load was chosen in accordance with the current rules (AIBA) 3x3 minute bouts with one minute break in between. Reaction time of rear straight lengthened (p<0...
March 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28276797/old-enemies-in-new-disguises-emergence-of-enterococcus-faecium-as-a-significant-clinical-problem-at-an-adult-haematology-ward
#19
Sari Hämäläinen, Jaana Pentikäinen, Jori Reijula, Ella Mauranen, Irma Koivula, Laura Lindholm, Auni Juutilainen, Tapio Nousiainen, Marja Pyörälä, Jaana Vuopio, Esa Jantunen
No abstract text is available yet for this article.
March 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28272424/restricted-use-of-erythropoiesis-stimulating-agent-is-safe-and-associated-with-deferred-dialysis-initiation-in-stage-5-chronic-kidney-disease
#20
Szu-Yu Pan, Wen-Chih Chiang, Ping-Min Chen, Heng-Hsiu Liu, Yu-Hsiang Chou, Tai-Shuan Lai, Chun-Fu Lai, Yen-Ling Chiu, Wan-Yu Lin, Yung-Ming Chen, Tzong-Shinn Chu, Shuei-Liong Lin
The effect of erythropoiesis-stimulating agent (ESA) on dialysis initiation in advanced chronic kidney disease (CKD) patients is not clear. We retrospectively analyzed the outcome of dialysis initiation in a stage 5 CKD cohort with ESA reimbursement limited to the maximal standardized monthly ESA dose equivalent to epoetin beta 20,000 U by the National Health Insurance program. Totally 423 patients were followed up for a median of 1.37 year. A time-dependent Cox regression model, adjusted for monthly levels of estimated glomerular filtration rate (eGFR) and hemoglobin, was constructed to investigate the association between ESA and outcome...
March 8, 2017: Scientific Reports
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