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https://www.readbyqxmd.com/read/27915456/use-of-iron-sucrose-and-red-blood-cell-transfusions-in-anaemic-cancer-patients-in-france-oncofer-study
#1
Elisabeth Luporsi, Alain Toledano, Dominique Spaeth, Florian Scotté, Marc Espié, Stéphanie Perot, Ladan Duvillié, Isabelle Pithois Merli, Roland Bugat
PURPOSE: This report describes the results of an observational, retrospective cohort study, evaluating the use of iron sucrose (IS) and red blood cell (RBC) transfusions in patients with cancer in routine clinical practice in France. A parallel investigated cohort treated with ferric carboxymaltose (FCM) has been reported earlier. METHODS: Data of patients with a solid tumour or haematological malignancy who have received IS or an RBC transfusion during 2010 from 3 months prior (M-3) to 3 months post first treatment (M+3) were analysed...
December 3, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27913517/treatment-of-low-risk-myelodysplastic-syndromes
#2
Valeria Santini
The majority of myelodysplastic syndrome (MDS) patients belong to the International Prognostic Scoring System (IPSS) and IPSS-revised (IPSS-R) lower-risk categories. Their precise diagnostics and prognostic stratification is often a challenge, but may ensure the optimization of therapy. The availability of diverse treatment options has significantly improved the quality of life and survival of this group of patients. Anemia is the most relevant cytopenia in terms of frequency and symptoms in lower-risk MDS, and may be treated successfully with erythropoietic stimulating agents, provided a careful selection is performed on the basis of IPSS-R, endogenous erythropoietin levels, and transfusion independence...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27909384/examining-emotional-support-animals-and-role-conflicts-in-professional-psychology
#3
Jeffrey N Younggren, Jennifer A Boisvert, Cassandra L Boness
This article examines the role conflicts that psychologists may face in their practices related to the evaluation and certification of emotional support animals (ESAs). It reviews the legal differences between ESAs and service animals (SAs), outlines ethical guidelines and legal policies/regulations regarding the use of ESAs, and examines the potential role conflicts that exist when a treating psychologist is certifying the need for an ESA. Finally, it makes recommendations to assist psychologists in staying within the standards of practice in order to avoid the ethical and legal risks associated with certifying an ESA...
August 2016: Professional Psychology, Research and Practice
https://www.readbyqxmd.com/read/27901331/clinical-indices-and-biomarkers-for-perioperative-cardiac-risk-stratification-an-update
#4
Radmilo J Janković, Danica Z Marković, Dušan T Sokolović, Ivana Zdravković, Massimiliano Sorbello
European Society of Cardiology (ESC)/ European Society of Anesthesiology (ESA) highlighted that anesthesiologist has a leading role in perioperative cardiovascular assessment and management in the year of 2014. During cardiovascular assessment one can rely on cooperation of multi-disciplinary specialists like: other anesthesiologists, cardiologists and surgeons. For the purpose of precise systematization and decision making the Lee score or NSQUIP database can be used besides the traditionally used ASA score...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27900963/initiation-of-darbepoetin-for-management-of-anemia-in-non-dialysis-dependent-patients-with-chronic-kidney-disease
#5
Fatma Al Raisi, Issa Al Salmi, Pramod Kamble, Muna Al Shehri, Faissal A M Shaheen
The anemia of chronic kidney disease (CKD) is a common comorbidity seen in kidney diseases. It is also associated with increased cardiovascular morbidity and mortality and diminished quality of life. Often, patients with CKD of different stages require erythropoiesis-stimulating agents (ESAs) to maintain their hemoglobin (Hb) within the target range. Darbepoetin alfa is a newer ESA with a longer half-life than recombinant human erythropoietin (EPO). The objective of this study is to assess the efficacy and safety profile of twice-monthly (Q2W) and once a month (1QM) darbepoetin alfa in CKD patients, not on dialysis...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899478/one-year-prospective-study-on-the-presence-of-chronic-diseases-and-subsequent-cognitive-decline-in-older-adults
#6
Hamzah Bakouni, Samantha Gontijo Guerra, Veronica Chudzinski, Djamal Berbiche, Helen-Maria Vasiliadis
BACKGROUND: The literature is inconsistent regarding the effect of the presence of chronic physical and mental diseases on cognitive decline in older adults. The objectives of this study were to explore the effect of chronic diseases on subsequent cognitive decline assessed via the Mini Mental State Examination (MMSE) in community living older adults. METHODS: We used data from individuals (n = 2010) participating in the ESA (Étude sur la Santé des Aînés) study...
November 29, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27899469/emergency-surgical-airways-following-activation-of-a-difficult-airway-management-team-in-hospitalized-critically-ill-patients-a-case-series
#7
REVIEW
Joseph M Darby, Gregory Halenda, Courtney Chou, Joseph J Quinlan, Louis H Alarcon, Richard L Simmons
INTRODUCTION: An emergency surgical airway (ESA) is widely recommended for securing the airway in critically ill patients who cannot be intubated or ventilated. Little is known of the frequency, clinical circumstances, management methods, and outcomes of hospitalized critically ill patients in whom ESA is performed outside the emergency department or operating room environments. METHODS: We retrospectively reviewed all adult patients undergoing ESA in our intensive care units (ICUs) and other hospital units from 2008 to 2012 following activation of our difficult airway management team (DAMT)...
November 28, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27895706/whole-genome-metabolic-model-of-trichoderma-reesei-built-by-comparative-reconstruction
#8
Sandra Castillo, Dorothee Barth, Mikko Arvas, Tiina M Pakula, Esa Pitkänen, Peter Blomberg, Tuulikki Seppanen-Laakso, Heli Nygren, Dhinakaran Sivasiddarthan, Merja Penttilä, Merja Oja
BACKGROUND: Trichoderma reesei is one of the main sources of biomass-hydrolyzing enzymes for the biotechnology industry. There is a need for improving its enzyme production efficiency. The use of metabolic modeling for the simulation and prediction of this organism's metabolism is potentially a valuable tool for improving its capabilities. An accurate metabolic model is needed to perform metabolic modeling analysis. RESULTS: A whole-genome metabolic model of T. reesei has been reconstructed together with metabolic models of 55 related species using the metabolic model reconstruction algorithm CoReCo...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27893131/association-between-palliative-care-and-patient-and-caregiver-outcomes-a-systematic-review-and-meta-analysis
#9
Dio Kavalieratos, Jennifer Corbelli, Di Zhang, J Nicholas Dionne-Odom, Natalie C Ernecoff, Janel Hanmer, Zachariah P Hoydich, Dara Z Ikejiani, Michele Klein-Fedyshin, Camilla Zimmermann, Sally C Morton, Robert M Arnold, Lucas Heller, Yael Schenker
Importance: The use of palliative care programs and the number of trials assessing their effectiveness have increased. Objective: To determine the association of palliative care with quality of life (QOL), symptom burden, survival, and other outcomes for people with life-limiting illness and for their caregivers. Data Sources: MEDLINE, EMBASE, CINAHL, and Cochrane CENTRAL to July 2016. Study Selection: Randomized clinical trials of palliative care interventions in adults with life-limiting illness...
November 22, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27892510/strong-quantum-scarring-by-local-impurities
#10
Perttu J J Luukko, Byron Drury, Anna Klales, Lev Kaplan, Eric J Heller, Esa Räsänen
We discover and characterise strong quantum scars, or quantum eigenstates resembling classical periodic orbits, in two-dimensional quantum wells perturbed by local impurities. These scars are not explained by ordinary scar theory, which would require the existence of short, moderately unstable periodic orbits in the perturbed system. Instead, they are supported by classical resonances in the unperturbed system and the resulting quantum near-degeneracy. Even in the case of a large number of randomly scattered impurities, the scars prefer distinct orientations that extremise the overlap with the impurities...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891685/the-dna-aptamer-binds-stemness-enriched-cancer-cells-in-pancreatic-cancer
#11
Yoon-Jin Kim, Hee Seung Lee, Dawoon E Jung, Jeong Mi Kim, Si Young Song
Pancreatic cancer remains one of the most common and lethal cancers. Most patients (80%) present with inoperable advanced pancreatic cancer at initial diagnosis, and their early diagnosis is a significant unmet challenge. Recent studies indicate that cancer, including pancreatic cancer, is initiated and propagated by cancer stem cells (CSCs). CSCs are responsible not only for the pathogenesis of cancer but also for the heterogeneity, malignant degree, anticancer therapy resistance, and recurrence of tumors...
November 28, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27885961/insig2-polymorphism-and-weight-gain-dyslipidemia-and-serum-adiponectin-in-finnish-patients-with-schizophrenia-treated-with-clozapine
#12
Suvi Koskinen, Olli Kampman, Anssi Solismaa, Leo-Pekka Lyytikäinen, Niko Seppälä, Merja Viikki, Mari Hämäläinen, Eeva Moilanen, Nina Mononen, Terho Lehtimäki, Esa Leinonen
AIM: To investigate INSIG2's association with obesity, weight change and serum lipid profile during clozapine treatment. MATERIALS & METHODS: Subjects with schizophrenia (n = 190) were genotyped, identifying seven SNPs. Genetic risk scores (GRSs) were calculated to adiponectin, high-density lipoprotein cholesterol, triglycerides and weight gain. RESULTS: In the model for weight gain, SNPs rs12151787, rs17047733 and rs10490626 were selected...
November 25, 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27883945/recent-advances-in-the-treatment-of-lower-risk-non-del-5q-myelodysplastic-syndromes-mds
#13
REVIEW
Antonio Almeida, Pierre Fenaux, Alan F List, Azra Raza, Uwe Platzbecker, Valeria Santini
Patients with lower-risk myelodysplastic syndromes (MDS) are affected primarily by symptoms of chronic anemia and fatigue rather than progression to acute myeloid leukemia. Severe thrombocytopenia, although less common in lower-risk MDS, is associated with increased risk of bleeding. For anemic patients, the principal aim of treatment is to improve anemia and decrease red blood cell transfusions. For transfusion-dependent patients with lower-risk MDS without chromosome 5q deletion [non-del(5q) MDS], there are limited effective treatments...
November 13, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27861459/effects-of-scheduled-waiting-for-psychotherapy-in-patients-with-major-depression
#14
Pasi Ahola, Mikko Joensuu, Paul Knekt, Olavi Lindfors, Pirjo Saarinen, Tommi Tolmunen, Minna Valkonen-Korhonen, Tuija Jääskeläinen, Esa Virtala, Jari Tiihonen, Johannes Lehtonen
The role of nonspecific factors in the outcome of psychotherapy is poorly understood. To study the effects of pretreatment expectancy of scheduled psychotherapy, we examined the effects of an agreed waiting time on the outcome of psychodynamic psychotherapy. Thirty-three treatment-naive outpatients with major depressive disorder were randomly selected to start psychotherapy either directly (DG; n = 17) or after waiting for 6 months (WG; n = 16). In WG, 18% to 60% of the total decline in symptoms took place during the waiting time...
November 16, 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27857321/improved-algorithm-for-the-transmittance-estimation-of-spectra-obtained-with-soir-venus-express
#15
Loic Trompet, Arnaud Mahieux, Bojan Ristic, Séverine Robert, Valérie Wilquet, Ian R Thomas, Ann Carine Vandaele, Jean-Loup Bertaux
The Solar Occultation in the InfraRed (SOIR) instrument onboard the ESA Venus Express spacecraft, an infrared spectrometer sensitive from 2.2 to 4.3 μm, probed the atmosphere of Venus from June 2006 until December 2014. During this time, it performed more than 750 solar occultations of the Venus mesosphere and lower thermosphere. A new procedure has been developed for the estimation of the transmittance in order to decrease the number of rejected spectra, to check that the treated spectra are well calibrated, and to improve the quality of the calibrated spectra by reducing the noise and accurately normalizing it to the solar spectrum...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27836781/nrf2-mediated-liver-protection-by-esculentoside-a-against-acetaminophen-toxicity-through-the-ampk-akt-gsk3%C3%AE-pathway
#16
Lidong Wang, Songling Zhang, Hang Cheng, Hongming Lv, Genhong Cheng, Xinxin Ci
Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant activities, but its therapeutic potential for APAP hepatotoxicity remains unknown. This study aimed to assess the protective effects and mechanism of EsA against APAP-induced hepatotoxicity in vitro and in vivo. In vitro, EsA treatment inhibited APAP- or H2O2-induced cytotoxicity, H2O2 and O2(-) production, glutathione (GSH) depletion and apoptosis dependent on nuclear factor erythroid-2-related factor 2 (Nrf2) activation in HepG2 cells...
November 9, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27833556/increased-motor-impairing-effects-of-the-neuroactive-steroid-pregnanolone-in-mice-with-targeted-inactivation-of-the-gabaa-receptor-%C3%AE-2-subunit-in-the-cerebellum
#17
Elli Leppä, Anni-Maija Linden, Maria I Aller, Peer Wulff, Olga Vekovischeva, Bernhard Luscher, Hartmut Lüddens, William Wisden, Esa R Korpi
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the α, β, and δ subunits of the receptor, especially on those that form extrasynaptic GABAA receptors responsible for non-synaptic (tonic) inhibition, but they also act on synaptically enriched γ2 subunit-containing receptors and even on αβ binary receptors. Here we tested whether behavioral sensitivity to the neuroactive steroid agonist 5β-pregnan-3α-ol-20-one is altered in genetically engineered mouse models that have deficient GABAA receptor-mediated synaptic inhibition in selected neuronal populations...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27828524/estimation-of-daily-photosynthetically-active-radiation-par-in-presence-of-low-to-high-aerosol-loads-application-to-olci-like-satellite-data
#18
Tristan Harmel, Malik Chami
Estimation of daily photosynthetically active radiation (PAR) is of primary importance for monitoring the ocean primary production and the subsequent production of carbon by phytoplankton at global scale from remote sensing ocean color sensors. On the other hand, aerosol abundance and composition play a critical role in the modulation of PAR. In this study, an original algorithm, so-called OLCIPAR, is proposed for routinely determining the daily PAR from optical satellite sensors such as the OLCI sensor aboard Sentinel-3 (ESA)...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27826250/static-and-dynamic-adaptation-of-insect-photoreceptor-responses-to-naturalistic-stimuli
#19
Andrew S French, Esa-Ville Immonen, Roman V Frolov
We describe a new nonlinear dynamic model of insect phototransduction using a NLN (nonlinear, linear, nonlinear) block structure. The first nonlinear stage provides a single exponential decline in gain and mean following the start of light stimulation. The linear stage uses a two-parameter log-normal convolution model previously applied alone to insect photoreceptors. The final stage is a static quadratic function. The model fitted current and voltage responses of isolated single photoreceptors from three different insect species with reasonable fidelity when they were stimulated by naturalistic time series having wide bandwidth and contrast, over a light intensity range of >1:10(4)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27823825/dynamics-of-chloroacetanilide-herbicides-in-various-types-of-mesocosm-wetlands
#20
Zhongbing Chen, Yi Chen, Jan Vymazal, Lumír Kule, Milan Koželuh
Constructed wetlands (CWs) for pesticide mitigation from agricultural runoff became widespread in the last decade. However, comparison of different types of CWs at one location is missing. Therefore, site by site comparison of three different types (subsurface flow, surface flow and floating hydroponic root mat) of CWs treating four chloroacetanilide herbicides (acetochlor, s-metolachlor, metazachlor, dimethachlor) were carried out. All three planted systems are effective in removing the four herbicides with removal efficiency >92% after 9days...
January 15, 2017: Science of the Total Environment
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