keyword
MENU ▼
Read by QxMD icon Read
search

ESA

keyword
https://www.readbyqxmd.com/read/28548470/whole-exome-sequencing-of-etv6-runx1-in-four-childhood-acute-lymphoblastic-leukaemia-cases
#1
Zubaidah Zakaria, Norodiyah Othman, Azli Ismail, Nor Rizan Kamaluddin, Ezalia Esa, Eni Juraida Abdul Rahman, Yuslina Mat Yusoff, Fazlin Mohd Fauzi, Ten Sew Keoh
Background: ETV6/RUNX1 gene fusion is the most frequently seen chromosomal abnormality in childhood acute lymphobastic leukamia (ALL). However, additional genetic changes are known to be required for the development of this type of leukaemia. Therefore, we here aimed to assess the somatic mutational profile of four ALL cases carrying the ETV6/RUNX1 fusion gene using whole-exome sequencing. Methods: DNA was isolated from bone marrow samples using a QIAmp DNA Blood Mini kit and subsequently sequenced using the Illumina MiSeq system...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28546302/considerations-and-controversies-in-managing-chronic-kidney-disease-an-update
#2
REVIEW
Lalita Prasad-Reddy, Diana Isaacs, Alexander Kantorovich
PURPOSE: Current considerations and controversies surrounding the management of chronic kidney disease (CKD) are reviewed. SUMMARY: Patients diagnosed with CKD require a unique clinical approach to prevent medication toxicities and ensure appropriate management of disease-progressing comorbidities, and they require attention to commonly occurring complications that may affect disease control and impact quality of life, including anemia and CKD-bone-mineral disorder (CKD-BMD)...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28545063/financial-distress-in-patients-with-advanced-cancer
#3
Cécile Barbaret, Christelle Brosse, Wadih Rhondali, Murielle Ruer, Léa Monsarrat, Patrick Michaud, Anne Marie Schott, Marvin Delgado-Guay, Eduardo Bruera, Stéphane Sanchez, Marilène Filbet
PURPOSE: We examined the frequency and severity of financial distress (FD) and its association with quality of life (QOL) and symptoms among patients with advanced cancer in France. DESIGN: In this cross-sectional study, 143 patients with advanced cancer were enrolled. QOL was assessed using the Functional Assessment of Cancer General (FACT-G) and symptoms assessed using Edmonton Assessment System (ESAS) and Hospital Anxiety and Depression Scale (HADS). FD was assessed using a self-rated numeric scale from 0 to 10...
2017: PloS One
https://www.readbyqxmd.com/read/28540993/administration-of-a-high-dose-erythropoietin-stimulating-agent-in-hemodialysis-patients-is-associated-with-late-arteriovenous-fistula-failure
#4
Hye Yun Jeong, Eun Jung Ko, Sang Hoon Kim, Mi Jung Lee, Hye Jeong Cho, Dong Ho Yang, So Young Lee
PURPOSE: Investigating the risk of vascular access failure is critical for maintenance hemodialysis (MHD) patients. Erythropoietin stimulating agents (ESA) typically used for anemia of chronic kidney disease (CKD) may also stimulate neointimal hyperplasia, which is the most important factor in late arteriovenous fistula (AVF) failure. The aim of this study was to investigate whether ESA treatment is associated with late AVF failure. MATERIALS AND METHODS: The late AVF failure group comprised 51 patients who underwent percutaneous intervention or surgery for fistula revision after successful use for at least three months...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28538306/effects-of-sparring-load-on-reaction-speed-and-punch-force-during-the-precompetition-and-competition-periods-in-boxing
#5
Esa Hukkanen, Keijo Häkkinen
Hukkanen, E and Häkkinen, K. Effects of sparring load on reaction speed and punch force during the precompetition and competition periods in boxing. J Strength Cond Res 31(6): 1563-1568, 2017-Seven, male, national-level boxers (age, 20.3 ± 2.7 years; height, 1.80 ± 0.06 m; mass, 73.8 ± 11.1 kg) participated in this study to investigate the effects of sparring on reaction time and punch force of straight punches measured during the precompetition and competition periods. Heart rate and blood lactate concentrations were also monitored...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28537456/angiogenic-profile-and-smoking-in-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec-cohort
#6
Tiina Jääskeläinen, Sanna Suomalainen-König, Esa Hämäläinen, Kari Pulkki, Jarkko Romppanen, Seppo Heinonen, Hannele Laivuori
Objectives The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. Subjects and Methods First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE. Second/third trimester serum samples were available from 174 PE and 54 non-PE women...
May 24, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28536884/an-update-in-symptom-clusters-using-the-edmonton-symptom-assessment-system-in-a-palliative-radiotherapy-clinic
#7
Vithusha Ganesh, Liying Zhang, Stephanie Chan, Bo Angela Wan, Leah Drost, May Tsao, Cyril Danjoux, Elizabeth Barnes, Rachel McDonald, Leigha Rowbottom, Pearl Zaki, Ronald Chow, Matthew K Hwang, Carlo DeAngelis, Nicholas Lao, Edward Chow
PURPOSE: To identify symptom clusters in advanced cancer patients attending a palliative radiotherapy clinic using the Edmonton Symptom Assessment System (ESAS). METHODS: Principal component analysis (PCA), exploratory factor analysis (EFA), and hierarchical cluster analysis (HCA) were used to identify symptom clusters among the nine ESAS items using scores from each patient's first visit. RESULTS: ESAS scores from 182 patients were analyzed...
May 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28534094/lifetime-traumatic-events-health-related-quality-of-life-and-satisfaction-with-life-in-older-adults
#8
Catherine Lamoureux-Lamarche, Helen-Maria Vasiliadis
PURPOSES: The aims were to assess the association between lifetime traumatic events and post-traumatic stress syndrome (PTSS) and health-related quality of life (HRQOL) and satisfaction with life stratified by gender among a community-dwelling sample of older adults. METHODS: Data used came from the ESA-Services study (2011-2013) and included a large convenience sample of 1811 older adults. Traumatic events were measured using a list of 14 events. PTSS was measured using the Impact of Event Scale-Revised...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28525891/identification-of-precision-treatment-strategies-for-relapsed-refractory-multiple-myeloma-by-functional-drug-sensitivity-testing
#9
Muntasir Mamun Majumder, Raija Silvennoinen, Pekka Anttila, David Tamborero, Samuli Eldfors, Bhagwan Yadav, Riikka Karjalainen, Heikki Kuusanmäki, Juha Lievonen, Alun Parsons, Minna Suvela, Esa Jantunen, Kimmo Porkka, Caroline A Heckman
Novel agents have increased survival of multiple myeloma (MM) patients, however high-risk and relapsed/refractory patients remain challenging to treat and their outcome is poor. To identify novel therapies and aid treatment selection for MM, we assessed the ex vivo sensitivity of 50 MM patient samples to 308 approved and investigational drugs. With the results we i) classified patients based on their ex vivo drug response profile; ii) identified and matched potential drug candidates to recurrent cytogenetic alterations; and iii) correlated ex vivo drug sensitivity to patient outcome...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28525291/the-state-of-opioid-agonist-therapy-in-canada-20-years-after-federal-oversight
#10
Joseph K Eibl, Kristen Morin, Esa Leinonen, David C Marsh
Opioid agonist therapy was introduced in Canada in 1959 with the use of methadone for the treatment of opioid dependence. The regulation of methadone was the responsibility of Health Canada until 1995, when oversight was transferred to the provincial health systems. During the more than 20 years since the federal health authority transferred oversight of methadone to the provincial level, methadone programming has evolved differently in every province. The landscape of opioid dependence treatment is varied across the country, with generally increasing treatment capacity in all provinces and dramatic increases in some...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28524660/photon-energy-threshold-in-direct-photocatalysis-with-metal-nanoparticles-key-evidence-from-the-action-spectrum-of-the-reaction
#11
Sarina Sarina, Esa Jaatinen, Qi Xiao, Yi Ming Huang, Philip Christopher, Jin Cai Zhao, Huai Yong Zhu
By investigating the action spectra (the relationship between the irradiation wavelength and apparent quantum efficiency of reactions under constant irradiance) of a number of reactions catalyzed by nanoparticles including plasmonic metals, nonplasmonic metals, and their alloys at near-ambient temperatures, we found that a photon energy threshold exists in each photocatalytic reaction; only photons with sufficient energy (e.g., higher than the energy level of the lowest unoccupied molecular orbitals) can initiate the reactions...
May 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28513765/factors-associated-with-suicidal-ideation-among-university-students
#12
Hugo Gedeon Barros Dos Santos, Samira Reschetti Marcon, Mariano Martínez Espinosa, Makilin Nunes Baptista, Paula Mirianh Cabral de Paulo
Objective: to analyze the factors associated with suicidal ideation in a representative sample of university students. Methods: cross-sectional study, carried out with 637 students of the Federal University of Mato Grosso. The presence of suicidal ideation, demographic and socioeconomic variables, use of alcohol through the Alcohol, Smoking and Substance Involvement Screening Test, and depressive symptoms (Major Depression Inventory) were investigated. Bivariate analysis was performed with the Chi-square test and multivariate analysis using the Poisson regression model...
May 15, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28513083/screen-printed-ambulatory-electrode-set-enables-accurate-diagnostics-of-sleep-bruxism
#13
Tomi Miettinen, Katja Myllymaa, Anu Muraja-Murro, Susanna Westeren-Punnonen, Taina Hukkanen, Juha Töyräs, Reijo Lappalainen, Esa Mervaala, Kirsi Sipilä, Sami Myllymaa
Currently, definite diagnosis of sleep bruxism requires polysomnography. However, it is restrictedly available, and too cumbersome and expensive for the purpose. The aim of this study was to introduce an ambulatory electrode set and evaluate its feasibility for more cost-effective diagnostics of sleep bruxism. Six self-assessed bruxers (one male, five females; aged 21-58 years) and six healthy controls (four males, two females, aged 21-25 years) underwent a standard polysomnographic study and a concurrent study with the ambulatory electrode set...
May 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28509707/burden-of-psychosocial-and-cognitive-impairment-in-patients-with-atrial-fibrillation
#14
John A Bostrom, Jane S Saczynski, Alexandra Hajduk, Kevin Donahue, Lawrence S Rosenthal, Clifford Browning, Cynthia Ennis, Kevin C Floyd, Heather Richardson, Nada Esa, Jessica Ogarek, David D McManus
BACKGROUND: Impairments in psychosocial status and cognition relate to poor clinical outcomes in patients with atrial fibrillation (AF). However, how often these conditions co-occur and associations between burden of psychosocial and cognitive impairment and quality of life (QoL) have not been systematically examined in patients with AF. METHODS: A total of 218 patients with symptomatic AF were enrolled in a prospective study of AF and psychosocial factors between May 2013 and October 2014 at the University of Massachusetts Medical Center...
June 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28509534/analysis-of-three-epoetin-alpha-products-by-lc-and-lc-ms-indicates-differences-in-glycosylation-critical-quality-attributes-including-sialic-acid-content
#15
Rebecca I Thomson, Richard Andrew Gardner, Katja Strohfeldt, Daryl L Fernandes, Graham Philip Stafford, Daniel I R Spencer, Helen M I Osborn
Erythropoietin (EPO) is one of the main treatments for anaemic patients, greatly improving their quality of life. In this study, biosimilars Binocrit and a development product, called here CIGB-EPO, were compared to the originator product, Eprex. All three are epoetin alpha products, reputed to have similar glycosylation profiles. The quality, safety and efficacy of this biotherapeutic depend on the following glycosylation critical quality attributes (GCQAs): sialylation, N-glycolyl-neuraminic acid (Neu5Gc) content, branching, N-acetyl-lactosamine (LacNAc) extensions and, arguably, O-acetylation pattern...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28508278/physiotherapy-programme-reduces-fatigue-in-patients-with-advanced-cancer-receiving-palliative-care-randomized-controlled-trial
#16
Anna Pyszora, Jacek Budzyński, Agnieszka Wójcik, Anna Prokop, Małgorzata Krajnik
PURPOSE: Cancer-related fatigue (CRF) is a common and relevant symptom in patients with advanced cancer that significantly decreases their quality of life. The aim of this study was to evaluate the effect of a physiotherapy programme on CRF and other symptoms in patients diagnosed with advanced cancer. METHODS: The study was designed as a randomized controlled trial. Sixty patients diagnosed with advanced cancer receiving palliative care were randomized into two groups: the treatment group (n = 30) and the control group (n = 30)...
May 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28506795/parallel-elisas-using-crude-soluble-antigen-and-excretory-secretory-antigen-for-improved-serodiagnosis-of-amoebic-liver-abscess
#17
Weng-Kin Wong, Phiaw-Chong Foo, Alfonso Olivos-Garcia, Rahmah Noordin, Zeehaida Mohamed, Nurulhasanah Othman, Ling-Ling Few, Boon-Huat Lim
Crude soluble antigen (CSA) produced from Entamoeba histolytica trophozoite is conventionally used for serodiagnosis of invasive amoebiasis. However, high background seropositivities by CSA-assay in endemic areas complicate the interpretation of positive result in clinical settings. Instead, incorporating a second assay which indicates active or recent infection into the routine amoebic serology could possibly complement the limitations of CSA-assay. Hence, the present study aimed to evaluate the diagnostic efficacies of indirect ELISAs using CSA and excretory-secretory antigen (ESA) for serodiagnosis of amoebic liver abscess (ALA)...
May 12, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28503810/a-minor-role-of-asparaginase-in-predisposing-to-cerebral-venous-thromboses-in-adult-acute-lymphoblastic-leukemia-patients
#18
Saara Roininen, Outi Laine, Marjut Kauppila, Marko Vesanen, Maria Rämet, Marjatta Sinisalo, Esa Jantunen, Marjaana Säily, Riikka Räty, Erkki Elonen, Ulla Wartiovaara-Kautto
Cerebral venous thrombosis (CVT) covers up to a third of all venous thromboses (VTs) detected in patients with acute lymphoblastic leukemia (ALL). It usually hampers patients' lives and may also endanger efficient leukemia treatment. Although many factors have been suggested to account for an elevated risk of VTs in patients with ALL, there still is a lack of studies focusing on CVTs and especially in the setting of adult ALL patients. We studied in our retrospective population-based cohort the occurrence, characteristics, as well as risk factors for VTs in 186 consecutively diagnosed Finnish adult ALL patients treated with a national pediatric-inspired treatment protocol ALL2000...
May 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28503212/associations-between-maternal-risk-factors-of-adverse-pregnancy-and-birth-outcomes-and-the-offspring-epigenetic-clock-of-gestational-age-at-birth
#19
Polina Girchenko, Jari Lahti, Darina Czamara, Anna K Knight, Meaghan J Jones, Anna Suarez, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Michael S Kobor, Alicia K Smith, Elisabeth B Binder, Katri Räikkönen
BACKGROUND: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28503167/the-impact-of-space-flight-on-survival-and-interaction-of-cupriavidus-metallidurans-ch34-with-basalt-a-volcanic-moon-analog-rock
#20
Bo Byloos, Ilse Coninx, Olivier Van Hoey, Charles Cockell, Natasha Nicholson, Vyacheslav Ilyin, Rob Van Houdt, Nico Boon, Natalie Leys
Microbe-mineral interactions have become of interest for space exploration as microorganisms could be used to biomine from extra-terrestrial material and extract elements useful as micronutrients in life support systems. This research aimed to identify the impact of space flight on the long-term survival of Cupriavidus metallidurans CH34 in mineral water and the interaction with basalt, a lunar-type rock in preparation for the ESA spaceflight experiment, BIOROCK. Therefore, C. metallidurans CH34 cells were suspended in mineral water supplemented with or without crushed basalt and send for 3 months on board the Russian FOTON-M4 capsule...
2017: Frontiers in Microbiology
keyword
keyword
23769
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"