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https://www.readbyqxmd.com/read/28645108/prognostic-factors-influencing-the-survival-of-patients-with-carcinoma-of-the-gastric-cardia-receiving-preoperative-interventional-embolization-chemotherapy
#1
Hai-Li Cao, Shu-Qiang Jin, Kai-Bing Wang, Bin Bai
The purpose of this study was to analyze the characteristics of patients with gastric cardia cancer (GCC) to identify the main factors the influence the survival rate after interventional embolization chemotherapy (IEC). One hundred and fifty-six patients with advanced GCC were treated with IEC via the left gastric artery. Survival time was defined as from the date of diagnosis until death or the end of this study in June 2015. The median survival time was 15 months (range 3 to 29 months). The Cox proportional hazard model found that patients' age (p< 0...
June 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644917/an-oxygen-isotope-chronometer-for-cellulose-deposition-the-successive-leaves-formed-by-tillers-of-a-c4-perennial-grass
#2
Hai Tao Liu, Fang Yang, Xiao Ying Gong, Rudi Schäufele, Hans Schnyder
Multiannual time series of (palaeo)hydrological information can be reconstructed from the oxygen isotope composition of cellulose (δ(18) OCel ) in biological archives, e.g. tree-rings, but our ability to temporally resolve information at subannual scale is limited. We capitalized on the short and predictable leaf appearance interval (2.4 d) of a perennial C4 grass (Cleistogenes squarrosa), to assess its potential for providing highly time-resolved δ(18) OCel records of vapor pressure deficit (VPD). Plants grown at low (0...
June 23, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28644752/expression-and-purification-of-swine-rag2-in-e-coli-for-production-of-porcine-rag2-polyclonal-antibodies
#3
Yu-Bei Jin, Wen-Tao Yang, Ke-Yan Huang, Hong-Liang Chen, Seria-Masole Shonyela, Jing Liu, Qiong Liu, Bo Feng, You Zhou, Shu-Li Zhi, Yan-Long Jiang, Jian-Zhong Wang, Hai-Bin Huang, Chun-Wei Shi, Gui-Lian Yang, Chun-Feng Wang
Recombination activating gene 2 (RAG2) is necessary for immature B cell differentiation. Antibodies to human and rabbit RAG2 are currently commercially available, but antibodies to swine RAG remain unavailable to date. In this study, the swine RAG2 genes sequence was synthesized and then cloned into a pET-28a vector. The recombinant fusion protein was successfully expressed in E. coli, purified through nickel column chromatography, and further digested with Tobacco Etch Virus protease. The cleaved protein was purified by molecular-exclusion chromatography and named pRAG2...
June 23, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28644707/relationship-between-neurocognitive-function-and-clinical-symptoms-with-self-stigma-in-patients-with-schizophrenia-spectrum-disorders
#4
Sherry Kit Wa Chan, Shiao Yan Sharon Kao, Shing Lam Leung, Christy Lai Ming Hui, Edwin Ho Ming Lee, Wing Chung Chang, Eric Yu Hai Chen
BACKGROUND: Self-stigma is associated with poor outcomes of patients with schizophrenia and development of self-stigma is a complex process. Results of studies on relationship of both positive and negative symptoms of psychosis with self-stigma have been inconsistent. Cognitive deficits are common to patients. However, number of studies exploring the relationship specifically between self-stigma and neurocognition are limited. AIMS: The current study aimed to examine the relationship between neurocognitive functions and clinical symptoms with self-stigma...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28644557/selective-arterial-embolization-for-the-treatment-of-sacral-and-pelvic-giant-cell-tumor-a-systematic-review
#5
REVIEW
Shao-Hui He, Wei Xu, Zheng-Wang Sun, Wei-Bo Liu, Yu-Jie Liu, Hai-Feng Wei, Jian-Ru Xiao
Giant cell tumor of the bone (GCTB) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT (SGCT) and pelvic GCT (PGCT), surgery has its limitations, especially for unresectable or recurrent tumors. Selective arterial embolization (SAE) is reported to be an option for treatment in several cases, but there are few systematic reviews on the effects of SAE on SGCT and/or PGCT. Medline and Embase databases were searched for eligible English articles. Inclusion and exclusion criteria were conducted before searching...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28644015/photochromic-hydrazone-switches-with-extremely-long-thermal-half-lives
#6
Hai Qian, Susnata Pramanik, Ivan Aprahamian
A family of easily accessible light-activated hydrazone switches has been developed having thermal half-lives of up to 2700 years! Structure-property analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with a phenyl one leads to the long-live negative photochromic compounds. The switching properties of the hydrazones in both toluene and DMSO were assessed offering insights into the kinetics and thermodynamics of the switching process.
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28643469/atra-signaling-regulates-the-expression-of-col9a1-through-bmp2-wnt4-runx1-pathway-in-antler-chondrocytes
#7
Hong-Liang Zhang, Bin Guo, Zhan-Qing Yang, Cui-Cui Duan, Shuang Geng, Kai Wang, Hai-Fan Yu, Zhan-Peng Yue
Although all-trans retinoic acid (ATRA) is involved in the regulation of cartilage growth and development, its regulatory mechanisms remain unknown. Here, we showed that ATRA could induce the expression of COL9A1 in antler chondrocytes. Silencing of cellular retinoic acid binding protein 2 (CRABP2) could impede the ATRA-induced upregulation of COL9A1, whereas overexpression of CRABP2 presented the opposite effect. RARα agonist Am80 induced the expression of COL9A1, whereas treatment with RARα antagonist Ro 41-5253 or RXRα small-interfering RNA (siRNA) caused an obvious blockage of ATRA on COL9A1...
June 22, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28643335/a-review-of-hemolysis-prediction-models-for-computational-fluid-dynamics
#8
REVIEW
Hai Yu, Sebastian Engel, Gábor Janiga, Dominique Thévenin
Flow-induced hemolysis is a crucial issue for many biomedical applications; in particular, it is an essential issue for the development of blood-transporting devices such as left ventricular assist devices, and other types of blood pumps. In order to estimate red blood cell (RBC) damage in blood flows, many models have been proposed in the past. Most models have been validated by their respective authors. However, the accuracy and the validity range of these models remains unclear. In this work, the most established hemolysis models compatible with computational fluid dynamics of full-scale devices are described and assessed by comparing two selected reference experiments: a simple rheometric flow and a more complex hemodialytic flow through a needle...
June 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28643180/first-complete-genome-sequences-of-genogroup-v-genotype-3-porcine-sapoviruses-common-5-terminal-genomic-feature-of-sapoviruses
#9
Tomoichiro Oka, Yen Hai Doan, Takashi Shimoike, Kei Haga, Takenori Takizawa
Sapoviruses (SaVs) are enteric viruses and have been detected in various mammals. They are divided into multiple genogroups and genotypes based on the entire major capsid protein (VP1) encoding region sequences. In this study, we determined the first complete genome sequences of two genogroup V, genotype 3 (GV.3) SaV strains detected from swine fecal samples, in combination with Illumina MiSeq sequencing of the libraries prepared from viral RNA and PCR products. The lengths of the viral genome (7494 nucleotides [nt] excluding polyA tail) and short 5'-untranslated region (14 nt) as well as two predicted open reading frames are similar to those of other SaVs...
June 22, 2017: Virus Genes
https://www.readbyqxmd.com/read/28643108/integrated-tk-td-modeling-for-drug-induced-concurrent-tachycardia-and-qt-changes-in-beagle-dogs
#10
Fan Wu, Tycho Heimbach, Panos Hatsis, Hai-Ming Tang, Raviprakash Dugyala, Qin Yue, Tao Wang, Handan He
Drug-induced cardiotoxicity, including tachycardia and QT prolongation, remains a major safety concern that needs to be identified and its risk mitigated in early stages of drug development. In the present study, an integrated toxicokinetic-toxicodynamic (TK-TD) modeling approach within a nonlinear mixed-effect modeling framework is applied to investigate concurrent abnormal heart rate and QT changes in three beagle dogs, using a Novartis internal compound (NVS001) as the case example. By accounting for saturable drug absorption, circadian rhythms, drug-effect tolerance, and nonlinear rate-dependency of QT interval, the dynamic TK-TD model captures the experimentally observed drug effects on heart rate and QT interval across a wide dosing range of NVS001 in beagle dogs...
June 22, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28643070/laparoscopic-revision-of-billroth-ii-with-braun-anastomosis-into-roux-en-y-anatomy-in-a-patient-with-intestinal-malrotation
#11
Fabio Garofalo, Omar Abouzahr, Henri Atlas, Ronald Denis, Pierre Garneau, Hai Huynh, Radu Pescarus
INTRODUCTION: Various reconstructions of the gastro-intestinal tract have been described in the past after distal gastrectomy. Among these, a Billroth II (BII) anastomosis can be performed with the addition of the Omega entero-enterostomy that may theoretically reduce the alkaline reflux. Given the significant complications associated with this procedure such as biliary reflux, marginal ulceration, and afferent loop syndrome, a revision into a Roux-en-Y anatomy is generally recommended...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28642968/enhancing-the-enzymatic-saccharification-of-bamboo-shoot-shell-by-sequential-biological-pretreatment-with-galactomyces-sp-cczu11-1-and-deep-eutectic-solvent-extraction
#12
Yong Dai, Hai-Sheng Zhang, Bin Huan, Yucai He
In this study, sequential biological pretreatment (BP) with Galactomyces sp. CCZU11-1 at 30 °C for 3 days and deep eutectic solvent (DES) choline chloride: oxalic acid (ChCl:OA, 1 mol/2 mol) extraction at 120 °C for 1.5 h was used for pretreating BSS. It was found that combination pretreatment could effectively remove xylan and lignin for enhancing enzymatic saccharification. The reducing sugars and glucose from the hydrolysis of 100 g/L pretreated BSS with complexed cellulases of Galactomyces sp. CCZU11-1 were obtained in the yields of 81...
June 22, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28642881/combining-carcinoembryonic-antigen-and-platelet-to-lymphocyte-ratio-to-predict-brain-metastasis-of-resected-lung-adenocarcinoma-patients
#13
Wei Wang, Chao Bian, Di Xia, Jin-Xi He, Ping Hai, Ren Zhao, Yan-Yang Wang
We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients. The records of 103 patients with completely resected lung adenocarcinoma between 2013 and 2014 were reviewed. Clinicopathologic characteristics of these patients were assessed in the Cox proportional hazards regression model. Brain metastasis occurred in 12 patients (11.6%). On univariate analysis, N2 stage (P = 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642758/time-and-antigen-stimulation-history-influence-memory-cd8-t-cell-bystander-responses
#14
Matthew D Martin, Qiang Shan, Hai-Hui Xue, Vladimir P Badovinac
Memory CD8 T cells can be activated and induced to produce cytokines and increase stores of cytolytic proteins not only in response to cognate antigen (Ag) but also in response to inflammatory cytokines (bystander responses). Importantly, bystander memory CD8 T cell functions have been shown to be dependent upon memory CD8 T cell fitness, since exhausted CD8 T cells have diminished capacity to respond to inflammatory cues. While it is known that memory CD8 T cell functional abilities, including ability to produce cytokines in response to cognate Ag, change with time after initial Ag encounter and upon multiple Ag stimulations (e...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28642641/inequality-in-human-capital-and-endogenous-credit-constraints
#15
Rong Hai, James J Heckman
This paper investigates the determinants of inequality in human capital with an emphasis on the role of the credit constraints. We develop and estimate a model in which individuals face uninsured human capital risks and invest in education, acquire work experience, accumulate assets and smooth consumption. Agents can borrow from the private lending market and from government student loan programs. The private market credit limit is explicitly derived by extending the natural borrowing limit of Aiyagari (1994) to incorporate endogenous labor supply, human capital accumulation, psychic costs of working, and age...
April 2017: Review of Economic Dynamics
https://www.readbyqxmd.com/read/28642590/toughening-fe-based-amorphous-coatings-by-reinforcement-of-amorphous-carbon
#16
Wei Wang, Cheng Zhang, Zhi-Wei Zhang, Yi-Cheng Li, Muhammad Yasir, Hai-Tao Wang, Lin Liu
Toughening of Fe-based amorphous coatings meanwhile maintaining a good corrosion resistance remains challenging. This work reports a novel approach to improve the toughness of a FeCrMoCBY amorphous coating through in-situ formation of amorphous carbon reinforcement without reducing the corrosion resistance. The Fe-based composite coating was prepared by high velocity oxy-fuel (HVOF) thermal spraying using a pre-mixed Fe-based amorphous/nylon-11 polymer feedstock powders. The nylon-11 powders were in-situ carbonized to amorphous carbon phase during thermal spraying process, which homogeneously distributed in the amorphous matrix leading to significant enhancement of toughness of the coating...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642154/a-boosting-skin-vaccination-with-dissolving-microneedle-patch-encapsulating-m2e-vaccine-broadens-the-protective-efficacy-of-conventional-influenza-vaccines
#17
Wandi Zhu, Winston Pewin, Chao Wang, Yuan Luo, Gilbert X Gonzalez, Teena Mohan, Mark R Prausnitz, Bao-Zhong Wang
The biodegradable microneedle patch (MNP) is a novel technology for vaccine delivery that could improve the immunogenicity of vaccines. To broaden the protective efficiency of conventional influenza vaccines, a new 4M2e-tFliC fusion protein construct containing M2e sequences from different subtypes was generated. Purified fusion protein was encapsulated into MNPs with a biocompatible polymer for use as a boosting vaccine. The results demonstrated that mice receiving a conventional inactivated vaccine followed by a skin-applied dissolving 4M2e-tFliC MNP boost could better maintain the humoral antibody response than that by the conventional vaccine-prime alone...
June 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28641893/recent-development-of-transition-metal-complexes-with-in-vivo-antitumor-activity
#18
Jia-Xin Liang, Hai-Jing Zhong, Guanjun Yang, Kasipandi Vellaisamy, Dik-Lung Ma, Chung-Hang Leung
The often severe side effects displayed by currently used platinum and ruthenium complexes have motivated researchers to design and develop transition metal-based anti-tumor agents with reduced toxicity. Distinct from organic anti-tumor drugs, transition metal complexes possess several properties that render them as promising scaffolds for anti-cancer drug discovery. While a vast number of metal complexes have been synthesized and reported to be promising and potent in vitro anticancer active compounds, fewer have shown efficacy in in vivo models...
June 16, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28641657/-affected-factors-of-separating-erythrocytes-by-discontinuous-of-density-gradient-centrifugation
#19
Meng-Xia Lin, Shuai Yu, Chao Zhu, Ya Huang, Hai-Bao Wang, Yang Yu
OBJECTIVE: To study the affected factors of the separation of red blood cells by discontinuous density gradient method, and to establish the optimal operating conditions of percoll for the separation of erythrocytes. METHODS: The osmolality of different ratio of Percoll and 1.5 mol/L NaCl were 9:1, 10:1, 11:1, 12:1, 13:1 ratio, was detected respectively. The isotonic osmolality ratio was selected as optimum stock isotonic Percoll solution(SIP). Evaluation criteria: All the different density cells were separated sufficiently by centrifugation, there is little red cell retention and entrainment phenomena...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28641654/-efficacy-and-safety-of-posaconazoleon-for-primary-antifungal-prophylaxis-against-invasive-fungal-disease-in-patients-with-stem-cell-transplantation
#20
Ya-Mei Wu, Yong-Bin Cao, Xiao-Hong Li, Li-Xin Xu, Bei Yan, Song-Wei Li, Hai-Tao Wang, Ya-Hui Gao, Tian-Tian Zhang, Ya-Qian Zhang, Li Wang, Xiao-Xiong Wu
OBJECTIVE: To investigate the efficacy and clinical safety of posaconazoleon primary antifungal prophylaxis against invasive fungal disease (IFD) in patients with stem cell transplantation. METHODS: At the start from preconditioning regimen, 45 patients without IFD were administered with posaconazoleon until neutrophils greater than 0.5×10(9)/L, 35 patients treated with micafungin were enrolled in control group. The incidence, risk factors of IFD and side effects of medicines were evaluated...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
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