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Hui Wang, Tao Feng, Ning Hai Zhuang, Min Zhi Xu, Ran Ye, Min Sun
This review attempts to visualize the actual impact of starch nanoparticle-based materials in different areas. In recent patent databases, starch nanoparticles showed the importance of this material, as well as relevant topics concerning the applications of starch nanoparticles in different domains. Because starch is environmentally friendly, starch nanoparticles are suggested as one of the promising biomaterials for novel utilization in foods, papermaking, medicines as well as various composites. In this review, the most common techniques for starch nanoparticles preparation were found to be acid and enzymatic procedures, ultrasonic treatment, combination of hydrolysis and Ultrasonic treatment, high pressure homogenization, enzymatic hydrolysis and recrystallization and emulsion-crosslinking...
March 20, 2018: Recent Patents on Food, Nutrition & Agriculture
Hai Shang, Zhi Qiang Hao, Xi Bo Fu, Xiang Dong Hua, Zuo Hong Ma, Fu Lu Ai, Zhao Qiang Feng, Kun Wang, Wen Xin Li, Bo Li
The proliferative activity of hepatic carcinoma cells is directly associated with tumorigenesis, tumor development, metastasis and invasion. A variety of cytokines and peptides serve important roles in the development of hepatic carcinoma. The aim of the present study was to examine the effect of intermedin (IMD) on hepatic carcinoma cell proliferation and its mechanism of action. HepG2 hepatic carcinoma cell lines were treated with human recombinant IMD1-53 and its receptor antagonist IMD17-47. Cell proliferation was detected using a Cell Counting kit-8...
April 2018: Oncology Letters
Weiwei Yan, Zhenyu Zhu, Fei Pan, Ang Huang, Guang-Hai Dai
Background: To explore new biomarkers for indicating the recurrence and prognosis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients after tumor resection, we investigated the expression and prognostic value of c-kit(CD117) in HBV-related HCC. Materials and methods: Immunohistochemistry was used to estimate the expression of c-kit(CD117) and CD34 in the liver cancer tissues. The correlations between the expression of these biomarkers and the clinicopathologic characteristics were analyzed...
2018: OncoTargets and Therapy
Hai-Yan Sun, Qiu Tang, Jian-Hong Chen, Xiao-Juan Lv, Ye-Qiang Tu, Ding-Ding Yan
Purpose: To determine if postoperative cisplatin concurrent chemoradiotherapy (CCRT) improves the outcome in stage IA/IIB cervical cancer patients with intermediate risk factors, when compared with radiation therapy (RT) alone, and identify the potential eligible populations for this treatment. Patients and methods: We reviewed medical records of 1,240 patients with stage IA/IIB cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy in our hospital between January 2008 and December 2011...
2018: OncoTargets and Therapy
Nassima Chouaki-Benmansour, Kilian Ruminski, Anne-Marie Sartre, Marie-Claire Phelipot, Audrey Salles, Elise Bergot, Ambroise Wu, Gaëtan Chicanne, Mathieu Fallet, Sophie Brustlein, Cyrille Billaudeau, Anthony Formisano, Sébastien Mailfert, Bernard Payrastre, Didier Marguet, Sophie Brasselet, Yannick Hamon, Hai-Tao He
Phosphoinositides (PIs) play important roles in numerous membrane-based cellular activities. However, their involvement in the mechanism of T cell receptor (TCR) signal transduction across the plasma membrane (PM) is poorly defined. Here, we investigate their role, and in particular that of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in TCR PM dynamics and activity in a mouse T-cell hybridoma upon ectopic expression of a PM-localized inositol polyphosphate-5-phosphatase (Inp54p). We observed that dephosphorylation of PI(4,5)P2 by the phosphatase increased the TCR/CD3 complex PM lateral mobility prior stimulation...
March 21, 2018: Scientific Reports
Xiaojian Yang, Fugui Yin, Yuhui Yang, Dion Lepp, Hai Yu, Zheng Ruan, Chengbo Yang, Yulong Yin, Yongqing Hou, Steve Leeson, Joshua Gong
Butyrate can modulate the immune response and energy expenditure of animals and enhance intestinal health. The present study investigated changes in the intestinal microbiota composition and serum metabolites of young broilers in response to 3,000 ppm butyrate in the form of butyrate glycerides (BG) via pyrosequencing of bacterial 16S rRNA genes and nuclear magnetic resonance (NMR). The dietary treatment did not affect the alpha diversity of intestinal microbiota, but altered its composition. Thirty-nine key operational taxonomic units (OTUs) in differentiating cecal microbiota community structures between BG treated and untreated chickens were also identified...
March 21, 2018: Scientific Reports
Dan Zhao, James Kit-Hon Tsoi, Hai Ming Wong, Chun Hung Chu, Jukka P Matinlinna
This study investigated the softening and erosive effects of various paediatric over-the-counter (OTC) oral liquids on deciduous teeth. Twenty sectioned and polished deciduous enamel blocks were ground on the buccal surface (2 × 2 mm²) and randomly divided into five groups, immersed into four commercially-available paediatric OTC oral liquids (two for paracetamol, both sugared; and two for chlorpheniramine, one sugared and one sugar-free), with deionized water as control. The pH of the oral liquids ranged from 2...
May 11, 2017: Dent J (Basel)
Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Ping Yan, Hai-Bing Zhou, Jian Huang
Gastric cancer is the second leading cause of cancer-related deaths in the world. SAHA, one of the emerging HDAC inhibitor widely used for cancer treatment, has unignorable side effects, as it is a multi-target HDAC inhibitor. However, it is believed that specifically targeting against fewer HDACs might decrease this cytoxin effect. In our previous work, we have designed and synthesized a series of new compounds, which specifically targets to HDAC6, and TC24 was one of them. In this study, we further demonstrated that TC24 selectively inhibited the activity of HDAC6 other than class I HDACs...
March 18, 2018: European Journal of Pharmacology
Sora Yoon, Hai C T Nguyen, Yun J Yoo, Jinhwan Kim, Bukyung Baik, Sounkou Kim, Jin Kim, Sangsoo Kim, Dougu Nam
Pathway-based analysis in genome-wide association study (GWAS) is being widely used to uncover novel multi-genic functional associations. Many of these pathway-based methods have been used to test the enrichment of the associated genes in the pathways, but exhibited low powers and were highly affected by free parameters. We present the novel method and software GSA-SNP2 for pathway enrichment analysis of GWAS P-value data. GSA-SNP2 provides high power, decent type I error control and fast computation by incorporating the random set model and SNP-count adjusted gene score...
March 19, 2018: Nucleic Acids Research
Liansheng Liu, Jinqiu Lu, Xiaoling Li, Ailing Wu, Qingzhe Wu, Mujun Zhao, Nan Tang, Hai Song
Intracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function. The cytoplasmic dynein motor and its regulatory proteins LIS1 and NDE1 are required for transporting a variety of cellular cargos along the microtubule network. In this study, we show that deletion of Lis1 in developing lung endoderm and limb mesenchymal cells causes agenesis of the lungs and limbs. In both mutants, there is increased cell death and decreased fibroblast growth factor (FGF) signaling activity...
March 20, 2018: Cell Reports
Yun Wang, Qing-Jiang Pang, Jiang-Tao Liu, Hai-Hao Wu, Dong-Ying Tao
MicroRNAs play a crucial role in the progression of spinal cord ischemia/reperfusion injury (SCII). The role of miR-448 and SIRT1 in SCII was investigated in this study, to provide further insights into prevention and improvement of this disorder. In this study, expressions of miR-448 and SIRT1 protein were determined by qRT-PCR and western blot, respectively. Flow cytometry was used to analyze cell apoptosis. The endogenous expression of genes was modulated by recombinant plasmids and cell transfection. Dual-luciferase reporter assay was performed to determine the interaction between miR-448 and SIRT1...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Richard Mbundu Ilunga, Céline Helbling, Lucie Favre, Tinh-Hai Collet
Obesity is associated with elevated levels of triglycerides, sometimes LDL-cholesterol, and lower levels of HDL-cholesterol. Management should first focus on dietary advices and increased physical activity, while lipid-lowering drugs are indicated only in patients at intermediate or high cardiovascular risk. We summarize nutritional recommendations from scientific societies: although they do not always overlap, they agree on lowering consumption of dietary fat (20-35 % of total energy intake) and favoring non-saturated fatty acids...
March 21, 2018: Revue Médicale Suisse
Tian Meng, Hai-Lin Zhang, Xiao Long, Xiao-Jun Wang
RATIONALE: A significant clinical issue for treating patients with large upper lip defects is how to reconstruct the lip functionally and aesthetically. Traditional methods usually lead to asymmetry of the nasal base, philtrum and the lips. PATIENT CONCERNS: A 22-year-old lady presented with a large congenital nevus on her upper lip which involved the cutaneous, vermilion, and the philtrum. Secondary deformity caused by previous partial excisions was also identified...
March 2018: Medicine (Baltimore)
Na-Na Tao, Rui Gong, Xiang Chen, Lin He, Fang Ren, Hai-Bo Yu, Juan Chen, Ji-Hua Ren
Hepatitis B virus (HBV) infection is a major health problem worldwide. Interleukin-35 (IL-35) is a definite immunosuppressive cytokine belonging to the IL-12 family. Nevertheless, the role of IL-35 in HBV replication remains elusive. In this study, we found that the level of HBV DNA replicative intermediates detected by qPCR and Southern blotting analysis was significantly increased by rhIL-35 in a dose-dependent manner. Moreover, HBV 3.5 kb mRNA levels were up-regulated by rhIL-35. The HBV core protein level as well as the HBsAg and HBeAg secretion levels were also increased by rhIL-35...
March 21, 2018: Journal of General Virology
Min Liu, Xu-Feng Yang, Hai-Bin Zhu, Bao-Sheng Di, Yue Zhao
A Keggin-type polyoxometalate (POM)-templated metal-organic framework, [Cd(TTPB-4)(DMF)3]4[PMo12O40]2[HPMo12O40]·6DMF·4H2O (1), based on a newly designed linker of TTPB-4 [TTPB-4 = 1,3,5-tris(4-(4H-1,2,4-triazol-4-yl)phenyl)benzene], has been hydrothermally synthesized and characterized using IR, XRD, TGA, UV-Vis and photoluminescence spectra. Single-crystal X-ray crystallography reveals that 1 represents a unique POM-templated four-fold interpenetrated 3-D coordination network. The POM-templated MOF of 1 exhibits strong chemical stability that can withstand aqueous solutions of various pH-values (2-10)...
March 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Jindan Li, Zijuan Hai, Huiqiong Xiao, Xiaoyi Yi, Gaolin Liang
Nanoprobes are advantageous over small molecular probes in sensitivity but most luminescence molecules used to construct nanoprobes often suffer from an aggregation-caused quenching effect. Herein, we rationally designed a small molecular probe Cys(StBu)-Lys(Ru(bpy)32+)-CBT (1) which "smartly" self-assembled into nanoparticles 1-NPs inside cells with non-quenched, persistent phosphorescence. Employing this property, we successfully applied 1 for long-term sensing of biothiol activity in living HepG2 cells and tumors...
March 21, 2018: Chemical Communications: Chem Comm
Hai-Shen Tang, De-Gang Wang, Lv-Yin Huang, Dong-Zhi Li
No abstract text is available yet for this article.
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Qiong Wang, Hai-Jiao Xing, Na Bao, Ling-Juan Kong, Ye-Juan Jia, Ke Yang, Yan-Hui Sun, Jian-Ling Wang, Jing Shi, Xiao-Feng Li, Jing Xu, Xuan-Ping Zhang, Xin Zhang, Chun-Sheng Jia, Ren-Ling Li
OBJECTIVE: To explore the regularity and characteristics of clinical application of scalp acupuncture therapy for different types of clinical conditions so as to provide a reference for clinical practice. METHODS: In the present study, "head acupuncture" and"scalp acupuncture" were used as the keywords to search papers and academic dissertations having definite standards for diagnosis and therapeutic effect assessment and published in journals and academic conferences collected in database China National Knowledge Internet(CNKI) from January 1 of 1959 to December 31 of 2016, followed by constructing a database after sorting, screening, recording, extracting, and statistical analysis by using a computer...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Ya-Ni Tang, Cheng-Fu Tan, Wei-Wei Liu, Jie Yan, Chao Wang, Mi Liu, Dong-Hai Lin, Cai-Hua Huang, Lin Du, Mei-Lin Chen, Jiao-Lan Li, Ding-Ming Zhu
OBJECTIVE: We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can improve myocardial ischemia in rats. The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy. METHODS: Thirty male SD rats were equally randomized into blank control, model and EA groups...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Ting-Ting Liu, Xi-Sheng Liu, Meng Zhang, Xue-Ni Liu, Fu-Xiang Zhu, Fang-Ming Zhu, Si-Wen Ouyang, Shan-Bao Li, Chen-Long Song, Hui-Min Sun, Su Lu, Yu Zhang, Jun Lin, Hua-Mei Tang, Zhi-Hai Peng
PURPOSE: Recent studies have determined that cartilage oligomeric matrix protein (COMP) plays a vital role in carcinogenesis. We sought to clarify the role of COMP in colon cancer. METHODS: We investigated gene expression data from The Cancer Genome Atlas (TCGA) dataset. Tissue microarrays (TMA) containing paired samples from 253 patients with colon cancer were subjected to immunostaining. COMP levels in serum of colon cancer patients and healthy donors were measured with ELISA...
March 20, 2018: Journal of Cancer Research and Clinical Oncology
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