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https://www.readbyqxmd.com/read/28302744/noninvasive-imaging-in-adult-congenital-heart-disease
#1
Luke J Burchill, Jennifer Huang, Justin T Tretter, Abigail M Khan, Andrew M Crean, Gruschen R Veldtman, Sanjiv Kaul, Craig S Broberg
Multimodality cardiovascular imaging plays a central role in caring for patients with congenital heart disease (CHD). CHD clinicians and scientists are interested not only in cardiac morphology but also in the maladaptive ventricular responses and extracellular changes predisposing to adverse outcomes in this population. Expertise in the applications, strengths, and pitfalls of these cardiovascular imaging techniques as they relate to CHD is essential. The purpose of this article is to provide an overview of cardiovascular imaging in CHD...
March 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28294860/-coronary-flow-reserve-in-the-left-anterior-and-posterior-descending-arteries-as-an-additional-option-to-dipyridamole-stress-echocardiography-for-detection-of-stenosis
#2
A A Boshchenko, A V Vrublevsky, R S Karpov
AIM: to assess additive diagnostic value of simultaneous evaluation of coronary flow reserve (CFR) in the left anterior descending (LAD) artery and posterior descending artery (PDA) during dipyridamole stress echocardiography (stress-Echo) for detection of LAD and PDA stenoses >50%. METHODS: 108 in-patients (mean age 50+/-11 years) with cardiac chest pain underwent dipyridamole stress-Echo with ECG-analysis, wall motion analysis by 2-dimentional imaging (2D) and coronary flow reserve (CFR) evaluation in both LAD and PDA by pulse-wave Doppler...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290842/-serial-assessment-of-transthoracic-coronary-flow-reserve-as-method-of-assessing-efficacy-of-intracoronary-intervention-in-the-left-anterior-and-posterior-descending-arteries
#3
A A Boshchenko, A V Vrublevsky, R S Karpov
Transthoracic echocardiography (TTE) has been described as an accurate technique for noninvasive evaluation of coronary flow reserve (CFR) of the left anterior descending artery (LAD) and posterior descending artery (PDA). Aim of this study was to find out whether serial measurement of CFR in LAD and PDA using TTE allows detection of stenosis elimination after intracoronary intervention and is a marker of successful procedure. METHODS: The study group comprised 14 patients with single-vessel coronary disease (stenosis 82+/-14%) of the LAD (9 patients) or right coronary artery (RCA, 5 patients) scheduled for stent implantation...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290836/-problems-and-perspectives-of-echocardiographic-evaluation-of-the-left-ventricular-diastolic-function
#4
M N Alekhin
This literature review is devoted to noninvasive evaluation of the left ventricular (LV) diastolic function by echocardiography with special stress on existing problems of detection of LV dysfunction by Doppler echocardiography of transmitral blood flow. Basing on existent algorithms one often cannot clearly judge whether LV dysfunction is present even when such methods are used as assessment of blood flow in pulmonary veins, transmitral blood flow during the Valsalva maneuver, etc. The review also contains discussion and analysis of newly suggested Doppler echocardiography based algorithms of detection of LV diastolic dysfunction and estimation of its severity (two-dimensional deformation of left atrial walls, three-dimensional echocardiography and three-dimensional deformation of the left ventricle)...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290006/exercise-testing-and-stress-imaging-in-mitral-valve-disease
#5
REVIEW
Damien Voilliot, Patrizio Lancellotti
Mitral valve disease represented by mitral stenosis and mitral regurgitation is the second most frequent valvulopathy. Mitral stenosis leads to an increased left atrial pressure whereas mitral regurgitation leads to an increased left atrial pressure associated with a volume overload. Secondary to an upstream transmission of this overpressure, both mitral stenosis and regurgitation lead to pulmonary hypertension and right heart failure. In addition, mitral regurgitation also leads to left ventricular dilatation and dysfunction with left heart failure...
March 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28288539/ischemia-modified-albumin-as-a-marker-of-vascular-dysfunction-and-subclinical-atherosclerosis-in-%C3%AE-thalassemia-major
#6
Amira Abdel Moneam Adly, Nayera Hazaa Khalil ElSherif, Eman Abdel Rahman Ismail, Yosra Abdelzaher Ibrahim, Gamal Niazi, Sara Hamed Elmetwally
BACKGROUND: Ischemia-modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and an independent predictor of major adverse cardiovascular events. OBJECTIVES: To measure the levels of IMA in 45 children and adolescents with β-thalassemia major (β-TM) compared with 30 healthy controls and assess its relation to lipid peroxidation, vascular complications and subclinical atherosclerosis. METHODS: β-TM patients without symptoms of heart disease were studied focusing on transfusion history, chelation therapy, serum ferritin, malondialdehyde (MDA) and IMA levels...
March 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28288162/left-ventricular-long-axis-tissue-doppler-systolic-velocity-is-independently-related-to-heart-rate-and-body-size
#7
Roger E Peverill, Bon Chou, Lesley Donelan
BACKGROUND: The physiological factors which affect left ventricular (LV) long-axis function are not fully defined. We investigated the relationships of resting heart rate and body size with the peak velocities and amplitudes of LV systolic and early diastolic long axis motion, and also with long-axis contraction duration. METHODS: Two groups of adults free of cardiac disease underwent pulsed-wave tissue Doppler imaging at the septal and lateral mitral annular borders...
2017: PloS One
https://www.readbyqxmd.com/read/28287506/assessment-of-pulmonary-capillary-blood-volume-membrane-diffusing-capacity-and-intrapulmonary-arteriovenous-anastomoses-during-exercise
#8
Vincent Tedjasaputra, Sean van Diepen, Sophie É Collins, Wade M Michaelchuk, Michael K Stickland
Exercise is a stress to the pulmonary vasculature. With incremental exercise, the pulmonary diffusing capacity (DLCO) must increase to meet the increased oxygen demand; otherwise, a diffusion limitation may occur. The increase in DLCO with exercise is due to increased capillary blood volume (Vc) and membrane diffusing capacity (Dm). Vc and Dm increase secondary to the recruitment and distension of pulmonary capillaries, increasing the surface area for gas exchange and decreasing pulmonary vascular resistance, thereby attenuating the increase in pulmonary arterial pressure...
February 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28279382/trials-of-imaging-use-in-the-emergency-department-for-acute-chest-pain
#9
REVIEW
Gilbert L Raff, Udo Hoffmann, James E Udelson
Over 8 million patients seek emergency department care for acute chest pain annually in the United States alone, and <5% have an acute coronary syndrome. In the absence of overt electrocardiographic or biomarker evidence, expensive and time-consuming diagnostic strategies are frequently required. Beginning in 2000, radionuclide myocardial perfusion, stress echocardiography, cardiac magnetic resonance imaging, and coronary computed tomographic angiography have become increasingly common in evaluating these patients...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28279226/the-ppar-pan-agonist-bezafibrate-ameliorates-cardiomyopathy-in-a-mouse-model-of-barth-syndrome
#10
Yan Huang, Corey Powers, Victoria Moore, Caitlin Schafer, Mindong Ren, Colin K L Phoon, Jeanne F James, Alexander V Glukhov, Sabzali Javadov, Frédéric M Vaz, John L Jefferies, Arnold W Strauss, Zaza Khuchua
BACKGROUND: The PGC-1α/PPAR axis has been proposed as a potential therapeutic target for several metabolic disorders. The aim was to evaluate the efficacy of the pan-PPAR agonist, bezafibrate, in tafazzin knockdown mice (TazKD), a mouse model of Barth syndrome that exhibits age-dependent dilated cardiomyopathy with left ventricular (LV) dysfunction. RESULTS: The effect of bezafibrate on cardiac function was evaluated by echocardiography in TazKD mice with or without beta-adrenergic stress...
March 9, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28274956/natriuretic-peptides-in-the-evaluation-and-management-of-degenerative-mitral-regurgitation-a-systematic-review
#11
REVIEW
Michael M Johl, Pankaj Malhotra, Devin W Kehl, Florian Rader, Robert J Siegel
Progression of degenerative mitral regurgitation (MR) leads to irreversible cardiac damage. Therefore, longitudinal follow up to determine the optimal timing of surgery is critical. Current data indicates that in addition to the standard of care-assessing for symptoms and signs of left ventricular (LV) decompensation with routine echocardiography-serial measurement of natriuretic peptides offers a quantitative means to identify patients who may benefit from closer supervision, if not surgery. Natriuretic peptide levels, and specifically changes from baseline, identify both symptomatic patients and others likely to develop cardiac dysfunction...
March 8, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28274518/replacing-the-anterior-mitral-valve-leaflet-with-autologous-jugular-vein-in-a-sheep-model
#12
Jacques T Janson, Andre Coetzee, Gawie Rossouw, Izak Loftus, Adriaan Murray, Pieter Rossouw, Philip Herbst
BACKGROUND: This study evaluated the use of an autologous vein graft, supported by expanded polytetrafluoroethylene (ePTFE) chordae tendineae, to replace an anterior mitral valve leaflet. METHODS: A double-layered autologous jugular vein graft, supported by ePTFE chords, was used to create an anterior mitral valve leaflet in 21 sheep. Mitral valve function was monitored with echocardiography for up to 10 months. Surviving sheep were euthanized between 6 and 10 months later, and vein implants were examined histologically...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28273654/cost-effectiveness-of-diagnostic-evaluation-strategies-for-individuals-with-stable-chest-pain-syndrome-and-suspected-coronary-artery-disease
#13
James K Min, Amanda Gilmore, Erica C Jones, Daniel S Berman, Wijnand J Stuijfzand, Leslee J Shaw, Ken O'Day, Ibrahim Danad
PURPOSE: To determine lifetime cost-effectiveness of diagnostic evaluation strategies for individuals with stable chest pain and suspected coronary artery disease (CAD). METHODS: Exercise treadmill testing (ETT), stress echocardiography (SE), myocardial perfusion scintigraphy (MPS), coronary computed tomographic angiography (CCTA), and invasive coronary angiography (ICA) were assessed alone, or in succession to each other. RESULTS: Initial ETT followed by imaging wherein ETT was equivocal or unable to be performed appeared more cost-effective than any strategy employing initial testing by imaging...
February 10, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28271289/diastolic-stress-echocardiography
#14
REVIEW
Tsutomu Takagi
Evaluation of diastolic dysfunction and diagnosis of heart failure with preserved ejection fraction (HFpEF) by echocardiography are routinely performed at rest. However, many patients with modest HFpEF develop symptoms such as dyspnea only during exercise. Therefore, echocardiographic analysis at rest could be insufficient to identify these patients. Recent studies have demonstrated the utility of diastolic stress echocardiography to evaluate diastolic dysfunction during exercise. This review attempts to summarize and discuss current studies in diastolic stress echocardiography...
March 7, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28269363/an-accelerometer-based-system-to-measure-myocardial-performance-index-during-stress-testing
#15
Anh Dinh, Francis M Bui, Tam Nguyen
Stress testing is used to measure the performance of the heart in an elevated stress state, in order to monitor or diagnose certain heart problems. Many measurements can be used to determine the performance of the heart, with the Tei index being the measurement of interest in this work. The Tei index has been used as a reliable method to evaluate systolic and diastolic performance, as it overcomes some limitations of the classical echocardiographic indices. It is calculated based on the time intervals derived from echocardiography...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268082/discrimination-of-stress-takotsubo-cardiomyopathy-from-acute-coronary-syndrome-with-clinical-risk-factors-and-coronary-evaluation-in-real-world-clinical-practice
#16
So-Ryoung Lee, Sang Eun Lee, Tae-Min Rhee, Jin Joo Park, Hyunjai Cho, Hae-Young Lee, Dong-Ju Choi, Byung-Hee Oh
BACKGROUND: Diagnosing stress cardiomyopathy (SCMP) apart from acute coronary syndrome (ACS) is challenging since coronary evaluation is not always feasible in real-world clinical practice. We explored the current practice pattern of coronary evaluation in patients suspected to have SCMP and divulged the distinguishable features of SCMP from ACS. METHODS AND RESULTS: From 2010 to 2015, only 219 out of 691 (32%) hospitalized patients suspected to have SCMP have received coronary evaluation in two tertiary hospitals...
February 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28261377/identification-of-patients-affected-by-mitral-valve-prolapse-with-severe-regurgitation-a-multivariable-regression-model
#17
Paola Songia, Benedetta Porro, Mattia Chiesa, Veronika Myasoedova, Francesco Alamanni, Elena Tremoli, Paolo Poggio
Background. Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. Besides echocardiography, up to now there are no reliable biomarkers available for the identification of this pathology. We aim to generate a predictive model, based on circulating biomarkers, able to identify MVP patients with the highest accuracy. Methods. We analysed 43 patients who underwent mitral valve repair due to MVP and compared to 29 matched controls. We assessed the oxidative stress status measuring the oxidized and the reduced form of glutathione by liquid chromatography-tandem mass spectrometry method...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28256328/additive-prognostic-values-of-nt-probnp-and-exercise-stress-echocardiography-in-asymptomatic-patients-with-degenerative-mitral-regurgitation-and-preserved-left-ventricular-ejection-fraction
#18
Sung-Ji Park, Eun Jeong Cho, Joonghyun Ahn, Keumhee Carriere, Eun Kyoung Kim, Ga Yeon Lee, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park
BACKGROUND: Exercise stress echocardiography (ESE) can be used to identify left ventricular (LV) dysfunction in asymptomatic chronic MR. NT-proBNP is the best marker for monitoring LV dysfunction. OBJECTIVE: The aim of this study was to estimate the complementary prognostic value of ESE and NT-proBNP in asymptomatic degenerative MR with preserved LV ejection fraction (EF). METHODS: Symptom-limited treadmill ESE was performed in 114 asymptomatic with significant degenerative MR (ERO >20mm, RV >30ml), LV end-systolic diameter <40mm and preserved LV function (EF >60%)...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28247428/predictors-and-prognostic-significance-of-atrial-fibrillation-developed-during-dobutamine-stress-echocardiography-a%C3%A2-propensity-score-matched-comparison
#19
Yuba Acharya, Sahil Agrawal, Junu Bhattarai, Vlad Cotarlan, Jamshid Shirani
AIMS: Atrial fibrillation (AF) uncommonly occurs during dobutamine stress echocardiography (DSE). We aimed to characterize the predictors and long-term prognostic significance of AF during DSE. METHODS: The clinical, echocardiographic, and outcome data of patients in sinus rhythm who developed AF during DSE were reviewed and compared to a propensity score-matched group of controls. RESULTS: Atrial fibrillation developed in 73 (1% of 7026) patients (age 70±10 years, 58% men)...
March 2017: Echocardiography
https://www.readbyqxmd.com/read/28242292/systemic-mastocytosis-kounis-syndrome-and-coronary-intervention-case-report-and-systematic-review
#20
REVIEW
Elizabeth D Paratz, Nancy Khav, Andrew T Burns
A 72-year-old male reported a long-standing history of unexplained syncope. Stress echocardiography demonstrated inducible anterior hypokinesis, and he proceeded to percutaneous coronary intervention for an 80% stenosis of the left anterior descending artery. Thirty minutes post-procedure, he experienced a pulseless electrical activity (PEA) cardiac arrest. Urgent repeat angiography demonstrated profound coronary artery spasm consistent with Kounis syndrome. Three days later, a second PEA arrest occurred. Systemic mastocytosis was ultimately diagnosed as the cause of his recurrent syncopal episodes and cardiac arrests...
February 15, 2017: Heart, Lung & Circulation
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