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https://www.readbyqxmd.com/read/27879516/performance-of-a-commercially-available-mal-antibody-in-the-diagnosis-of-primary-mediastinal-large-b-cell-lymphoma
#1
Michael Gentry, Juraj Bodo, Lisa Durkin, Eric D Hsi
Myelin and lymphocyte (MAL) protein has been previously reported as a highly specific marker for distinguishing primary mediastinal large B-cell lymphoma (PMBL) from diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). However, there has not been a commercially available MAL antibody for immunohistochemistry. We identified a commercially available MAL monoclonal antibody and evaluated it by immunohistochemistry on 43 cases of PMBL and 63 cases of DLBCL, NOS. We also compared this with a CD200 antibody that was previously reported useful in distinguishing PMBL and DLBCL, NOS...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27821974/effect-of-mental-practice-using-inverse-video-of-the-unaffected-upper-limb-in-a-subject-with-chronic-hemiparesis-after-stroke
#2
Naoki Iso, Shirou Ooso, Noboru Yamamoto, Takefumi Moriuchi, Akira Sagari, Fumiko Iso, Koji Tanaka, Takayuki Tabira, Toshio Higashi
[Purpose] The aim of this case study was to investigate whether a method of mental practice (MP) using an inverse video of a subject's unaffected limb to complement the vividness of motor imagery (MI) would be effective for improving affected upper limb function. [Subjects and Methods] The participant was 60-year-old male in the chronic stage of stroke recovery with left sided hemiparesis. The design of the study was AB method of Single-System-Design. He performed the MP as a home program with DVD. The intervention lasted 30 minutes a session, twice a day, 5 times a week, over 6 weeks...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27793071/self-training-to-improve-ue-function-at-the-chronic-stage-post-stroke-a-pilot-randomized-controlled-trial
#3
Debbie Rand, Harold Weingarden, Ronit Weiss, Anat Yacoby, Shlomit Reif, Rachel Malka, David Andrew Shiller, Gabi Zeilig
BACKGROUND AND PURPOSE: On-going practice and use of the weaker upper extremity (UE) are important for maintaining and improving function in individuals with chronic stroke. The effectiveness of two self-training programs for UE function and daily-use was compared. METHODS: In this pilot, single-blinded clinical trial, individuals with chronic stroke were randomized to video-games or traditional self-training (1-hour/day, 6-times/week, 5 weeks). Assessments were performed pre-intervention (an average of two assessments), post-intervention, and at 4-week follow-up...
October 28, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27788605/a-consensus-on-the-use-of-daylight-photodynamic-therapy-in-the-uk
#4
Sally Ibbotson, Robin Stones, Jonathan Bowling, Sandra Campbell, Stephen Kownacki, Muthu Sivaramakrishnan, Ronan Valentine, Colin A Morton
BACKGROUND: Actinic keratoses (AKs) are a consequence of chronic exposure to ultraviolet radiation. Treatment of chronically photo-damaged skin and AKs is driven by risk of progression to squamous cell carcinoma, as well as for symptomatic relief. Conventional photodynamic therapy (c-PDT) is indicated when AKs are multiple or confluent and if patients respond poorly or are unable to tolerate other therapies. c-PDT is limited by the field size that can be treated in single sessions and can cause significant discomfort...
October 27, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27723324/plasmonically-engineered-nanoprobes-for-biomedical-applications
#5
Amit Kumar, Sungi Kim, Jwa-Min Nam
The localized surface plasmon resonance of metal nanopar-ticles is the collective oscillation of electrons on particle surface, and is a particle composition, morphology and cou-pling-dependent property. Plasmonic engineering deals with highly precise formation of the targeted nanostructures with targeted plasmonic properties (e.g., electromagnetic field distribution and enhancement) via controlled synthetic, assembling and atomic/molecular tuning strategies. These plasmonically engineered nanostructures (PENs) have a variety of unique and beneficial physical, chemical and bio-logical properties including optical signal enhancement, catalytic property and local temperature-tuning photother-mal property...
October 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27446776/effects-of-adjuvant-mental-practice-on-affected-upper-limb-function-following-a-stroke-results-of-three-dimensional-motion-analysis-fugl-meyer-assessment-of-the-upper-extremity-and-motor-activity-logs
#6
Hyun Seung Oh, Eun Joo Kim, Doo Young Kim, Soo Jeong Kim
OBJECTIVE: To investigate the effects of adjuvant mental practice (MP) on affected upper limb function following a stroke using three-dimensional (3D) motion analysis. METHODS: In this AB/BA crossover study, we studied 10 hemiplegic patients who had a stroke within the past 6 months. The patients were randomly allocated to two groups: one group received MP combined with conventional rehabilitation therapy for the first 3 weeks followed by conventional rehabilitation therapy alone for the final 3 weeks; the other group received the same therapy but in reverse order...
June 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27409613/mal-daylight-photodynamic-therapy-for-actinic-keratosis-clinical-and-imaging-evaluation-by-3d-camera
#7
Carmen Cantisani, Giovanni Paolino, Giovanni Pellacani, Dario Didona, Marco Scarno, Valentina Faina, Tommaso Gobello, Stefano Calvieri
Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common and reflect an abnormal multistep skin cell development due to the chronic ultraviolet (UV) light exposure. No ideal treatment exists, but the potential risk of their development in a more invasive form requires prompt treatment. As patients usually present with multiple AK on fields of actinic damage, there is a need for effective, safe, simple and short treatments which allow the treatment of large areas...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27347225/long-term-arrhythmia-monitoring-in-cryptogenic-stroke-who-how-and-for-how-long
#8
Mayra Montalvo, Rushna Ali, Brian Silver, Muhib Khan
Cryptogenic stroke and transient ischemic attack (TIA) account for approximately one-third of stroke patients [1]. Paroxys-mal atrial fibrillation (PAF) has been suggested as a major etiology of these cryptogenic strokes [2, 3]. PAF can be difficult to diagnose because it is intermittent, often brief, and asymptomatic. PAF might be more prevalent than persistent atrial fibrillation in stroke and TIA patients, especially in younger populations [4, 5]. In patients with atrial fibrillation, anticoagulation provides significant risk reduction [6]...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27110357/moving-in-extreme-environments-extreme-loading-carriage-versus-distance
#9
REVIEW
Samuel J E Lucas, Jørn W Helge, Uwe H W Schütz, Ralph F Goldman, James D Cotter
This review addresses human capacity for movement in the context of extreme loading and with it the combined effects of metabolic, biomechanical and gravitational stress on the human body. This topic encompasses extreme duration, as occurs in ultra-endurance competitions (e.g. adventure racing and transcontinental races) and expeditions (e.g. polar crossings), to the more gravitationally limited load carriage (e.g. in the military context). Juxtaposed to these circumstances is the extreme metabolic and mechanical unloading associated with space travel, prolonged bedrest and sedentary lifestyle, which may be at least as problematic, and are therefore included as a reference, e...
2016: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/27070955/bioengineered-probiotics-as-a-new-hope-for-health-and-diseases-an-overview-of-potential-and-prospects
#10
Manoj Kumar, Ashok Kumar Yadav, Vinod Verma, Birbal Singh, Gorakh Mal, Ravinder Nagpal, Rajkumar Hemalatha
Despite the use of microorganisms as therapeutics for over a century, the scientific and clinical admiration of their potential is a recent phenomenon. Genome sequencing and genetic engineering has enabled researchers to develop novel strategies, such as bioengineered probiotics or pharmabiotics, which may become a therapeutic strategy. Bioengineered probiotics with multiple immunogenic or antagonistic properties could be a viable option to improve human health. The bacteria are tailored to deliver drugs, therapeutic proteins or gene therapy vectors with precision and a higher degree of site specificity than conventional drug administration regimes...
2016: Future Microbiology
https://www.readbyqxmd.com/read/27041899/extraction-protocols-for-orthodontic-treatment-a-retrospective-study
#11
Vaishnevi N Thirunavukkarasu, Srinivas Sulugodu Ramachandra, Daniel D Dicksit, Kalyan C Gundavarapu
BACKGROUND AND OBJECTIVES: Various extraction protocols have been followed for successful orthodontic treatment. The purpose of this study was to evaluate the extraction protocols in patients who had previously undergone orthodontic treatment and also who had reported for continuing orthodontic treatment from other clinics. MATERIALS AND METHODS: One hundred thirty eight patients who registered for orthodontic treatment at the Faculty of Dentistry were divided into 10 extraction protocols based on the Orthodontic treatment protocol given by Janson et al...
January 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/26995005/illness-perceptions-are-associated-with-mortality-among-1552-colorectal-cancer-survivors-a-study-from-the-population-based-profiles-registry
#12
Melissa S Y Thong, Adrian A Kaptein, Pauline A J Vissers, Gerard Vreugdenhil, Lonneke V van de Poll-Franse
PURPOSE: Cancer survivors construct perceptions of illness as a (mal)adaptive mechanism. These perceptions motivate/drive subsequent self-management behaviors toward symptoms and treatment that influence health outcomes. Negative illness perceptions have been associated with increased mortality in other chronically ill groups. However, this association is under-researched in cancer survivors. We aimed to explore the association between illness perceptions and mortality in stage I-III progression-free colorectal cancer (CRC) survivors...
October 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/26956030/full-protection-of-swine-against-foot-and-mouth-disease-by-a-bivalent-b-cell-epitope-dendrimer-peptide
#13
Esther Blanco, Beatriz Guerra, Beatriz G de la Torre, Sira Defaus, Aldo Dekker, David Andreu, Francisco Sobrino
Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. We have reported (Cubillos et al., 2008) that a synthetic dendrimeric peptide consisting of four copies of a B-cell epitope [VP1(136-154)] linked through thioether bonds to a T-cell epitope [3A(21-35)] of FMDV [B4T(thi)] elicits potent B- and T-cell specific responses and confers solid protection in pigs to type C FMDV challenge. Herein we show that downsized versions of this peptide bearing two copies of a B-cell epitope from a type O isolate and using thioether [B2T(thi)] or maleimide [B2T(mal)] conjugation chemistries for their synthesis elicited in swine similar or higher B and T-cell specific responses than tetravalent B4T(thi)...
May 2016: Antiviral Research
https://www.readbyqxmd.com/read/26949145/chest-radiograph-after-fluoroscopic-guided-line-placement-no-longer-necessary
#14
Brian G A Dalton, Katherine W Gonzalez, Michael C Keirsy, Douglas C Rivard, Shawn D St Peter
PURPOSE: Historically, a chest radiograph was obtained after central line placement in the operating room. Recent retrospective studies have questioned the need for this radiograph. The prevailing current practice at our center is to order chest radiograph only for symptomatic patients. This study examines the outcomes of selective chest radiography after fluoroscopic guided central line placement. METHODS: After obtaining institutional review board approval, a single institution retrospective chart review of patients undergoing central venous catheter placement by the pediatric surgery or interventional radiology service between January 2010 and July 2014 was performed...
September 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26862533/protective-effect-of-selenium-based-medicines-on-toxicity-of-three-common-organophosphorus-compounds-in-human-erythrocytes-in-vitro
#15
Maryam Sadat Fakhri-Bafghi, Seyedeh Farnaz Ghasemi-Niri, Sara Mostafalou, Mona Navaei-Nigjeh, Maryam Baeeri, Azadeh Mohammadirad, Mohammad Abdollahi
OBJECTIVE: Organophosphorus (OP) compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase (AChE) inhibition and oxidative stress (OS). Among the OPs, chlorpyrifos (CHP), malathion (MAL), and diazinon (DIA) are commonly used for commercial extermination purposes, in addition to veterinary practices, domestic, agricul- ture and public health applications. Two new recently registered medicines that contain selenium and other antioxidants, IMOD and angipars (ANG), have shown beneficial ef- fects for OS related disorders...
2016: Cell Journal
https://www.readbyqxmd.com/read/26861915/enhancing-future-acceptance-of-rural-placement-in-tanzania-through-peripheral-hospital-rotations-for-medical-students
#16
Gibson Erick Kapanda, Charles Muiruri, Ahaz T Kulanga, Chrispina N Tarimo, Esther Lisasi, Lucy Mimano, Kien Mteta, John A Bartlett
BACKGROUND: Mal-distribution of health care workers is a global health challenge that exacerbates health disparities, especially in resource-limited settings. Interventions to mitigate the problem have targeted qualified personnel with little focus on medical students. However, studies have demonstrated that rural rotations positively influence students to practice in rural settings upon graduation. To evaluate the influence of peripheral rotations in a resource-limited setting, the Kilimanjaro Christian Medical University College introduced a 12-week clerkship rotation in peripheral hospitals for third-year medical (MD3) students in 2012...
2016: BMC Medical Education
https://www.readbyqxmd.com/read/26827831/-reps-aren-t-enough-augmenting-functional-electrical-stimulation-with-behavioral-supports-significantly-reduces-impairment-in-moderately-impaired-stroke
#17
Stephen J Page, Peter G Levine, Brittani A Basobas
OBJECTIVE: To determine the impact of repetitive task-specific practice (RTP) integrating electrical stimulation and behavioral supports on upper extremity (UE) impairment, gross manual dexterity, and paretic UE amount and quality of use in chronic stroke survivors exhibiting moderate, stable UE deficits. DESIGN: Case series with 3-month follow-up. SETTING: Outpatient rehabilitation hospital. PARTICIPANTS: Persons (N=9) who experienced a stroke >12 months before enrollment and exhibiting chronic, moderate, stable UE impairment...
May 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/26774818/chronic-intermittent-abdominal-pain-in-young-woman-with-intestinal-malrotation-fitz-hugh-curtis-syndrome-and-appendiceal-neuroendocrine-tumor-a-rare-case-report-and-literature-review
#18
REVIEW
Alessia Cusimano, Ahmed Mohammed Alaaeldien Beniamin Abdelghany, Andrea Donadini
BACKGROUND: There are a lot of different causes of abdominal pain; in this case, a young woman suffers from three diseases with similar symptoms. Adult intestinal mal-rotation is a rare condition of deviation from the normal 270° counter clockwise rotation of the midgut resulting in, not only mal-position of the small intestine, but also mal-fixation of the mesentery. Fitz-Hugh-Curtis syndrome is a rare complication of pelvic inflammatory disease; it involves liver capsule inflammation associated with genital tract infection, which is usually caused by Neisseria gonorrhoea and Chlamydia trachomatis...
2016: BMC Women's Health
https://www.readbyqxmd.com/read/26612792/daylight-pdt-with-mal-current-data-and-practical-recommendations-of-an-expert-panel
#19
REVIEW
Wolfgang G Philipp-Dormston, Sigrid Karrer, Holger Petering, Claas Ulrich, Thomas Dirschka, Carola Berking, Anke S Lonsdorf, Peter Arne Gerber, Sonja Radakovic, Robert E Hunger, Rolf-Markus Szeimies
Photodynamic Therapy (PDT) is one of the standard treatment modalities for actinic keratoses (AKs). Daylight PDT (DL-PDT) with MAL cream is a rather recent development, which, instead of an artificial light source, uses daylight for the activation of the photosensitizer. The present review summarizes available data based on a selective literature search, highlights practical aspects, and reflects the authors' expert knowledge in using DL-PDT. With respect to efficacy, study data shows that DL-PDT is noninferior to conventional PDT (cPDT)...
December 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/26486305/the-chloroplast-genome-hidden-in-plain-sight-open-access-publishing-and-anti-fragile-distributed-data-sources
#20
Kevin Judd McKernan
We sequenced several cannabis genomes in 2011 of June and the first and the longest contigs to emerge were the chloroplast and mitochondrial genomes. Having been a contributor to the Human Genome Project and an eye-witness to the real benefits of immediate data release, I have first hand experience with the potential mal-investment of millions of dollars of tax payer money narrowly averted due to the adopted global rapid data release policy. The policy was vital in reducing duplication of effort and economic waste...
October 21, 2015: Mitochondrial DNA
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