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https://www.readbyqxmd.com/read/29783774/d-amino-acid-peptide-residualizing-agents-for-protein-radioiodination-effect-of-aspartate-for-glutamate-substitution
#1
Marek Pruszynski, Choong Mo Kang, Eftychia Koumarianou, Ganesan Vaidyanathan, Michael R Zalutsky
The residualizing prosthetic agent N ε -(3-[* I]iodobenzoyl)-Lys⁵- N α -maleimido-Gly¹-d-GEEEK ([* I]IB-Mal-d-GEEEK) showed promise for the radioiodination of monoclonal antibodies (mAbs) that bind to internalizing molecular targets. Although enhanced tumor uptake was achieved in these studies, elevated kidney accumulation also was observed, particularly with low-molecular-weight, single-domain antibody fragments (sdAbs). Here, we developed an analogous agent (IB-Mal-d-GDDDK), in which glutamate residues (E) were replaced with aspartates (D) to determine whether this modification could decrease renal uptake...
May 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29697043/infant-feeding-practices-and-determinant-variables-for-early-complementary-feeding-in-the-first-8-months-of-life-results-from-the-brazilian-mal-ed-cohort-site
#2
Bll Maciel, M L Moraes, A M Soares, Ifs Cruz, Mir de Andrade, J Q Filho, F S Junior, P N Costa, C B Abreu, R Ambikapathi, R L Guerrant, L E Caulfield, Aam Lima
OBJECTIVE: The present study aimed to describe breast-feeding, complementary feeding and determining factors for early complementary feeding from birth to 8 months of age in a typical Brazilian low-income urban community. DESIGN: A birth cohort was conducted (n 233), with data collection twice weekly, allowing close observation of breast-feeding, complementary feeding introduction and description of the WHO core indicators on infant and young child feeding. Infant feeding practices were related to socio-economic status (SES), assessed by Water/sanitation, wealth measured by a set of eight Assets, Maternal education and monthly household Income (WAMI index)...
April 26, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29669466/-everything-changes-listening-to-homicidally-bereaved-individuals-practice-and-intervention-needs
#3
Filipa Alves-Costa, Catherine Hamilton-Giachritsis, Sarah Halligan
This study sought to understand how individuals bereaved through homicide (murder or manslaughter) describe their postevent experiences to inform clinical needs and promote mechanisms for change. A total of 21 participants (18 females) between the ages of 29 and 66 ( M age = 47.81 years, SD = 8.99) took part in this study. They were all participating in a residential program for homicidally bereaved individuals and were all residents in the United Kingdom. The sample comprised of 12 parents, five siblings, one partner, one daughter, one friend, and one grandmother of the deceased...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29534766/seasonality-and-within-subject-clustering-of-rotavirus-infections-in-an-eight-site-birth-cohort-study
#4
J M Colston, A M S Ahmed, S B Soofi, E Svensen, R Haque, J Shrestha, R Nshama, Z Bhutta, I F N Lima, A Samie, L Bodhidatta, A A M Lima, P Bessong, M Paredes Olortegui, A Turab, V R Mohan, L H Moulton, E N Naumova, G Kang, M N Kosek
Improving understanding of the pathogen-specific seasonality of enteric infections is critical to informing policy on the timing of preventive measures and to forecast trends in the burden of diarrhoeal disease. Data obtained from active surveillance of cohorts can capture the underlying infection status as transmission occurs in the community. The purpose of this study was to characterise rotavirus seasonality in eight different locations while adjusting for age, calendar time and within-subject clustering of episodes by applying an adapted Serfling model approach to data from a multi-site cohort study...
April 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29485737/hypertension-in-pregnancy-taking-cues-from-pathophysiology-for-clinical-practice
#5
REVIEW
Ruxandra I Sava, Keith L March, Carl J Pepine
Pregnancy-related hypertension (PHTN) syndromes are a frequent and potentially deadly complication of pregnancy, while also negatively impacting the lifelong health of the mother and child. PHTN appears in women likely to develop hypertension later in life, with the stress of pregnancy unmasking a subclinical hypertensive phenotype. However, distinguishing between PHTN and chronic hypertension is essential for optimal management. Preeclampsia (PE) is linked to potentially severe outcomes and lacks effective treatments due to poorly understood mechanisms...
February 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29454583/post-operative-ventricular-flow-dynamics-following-atrioventricular-valve-surgical-and-device-therapies-a-review
#6
REVIEW
Yen Ngoc Nguyen, Munirah Ismail, Foad Kabinejadian, Edgar Lik Wui Tay, Hwa Liang Leo
Intra-ventricular flow dynamics has recently emerged as an important evaluation and diagnosis tool in different cardiovascular conditions. The formation of vortex pattern during the cardiac cycle has been suggested to play important epigenetic and energy-modulation roles in cardiac remodelling, adaptations and mal-adaptations. In this new perspective, flow alterations due to different cardiovascular procedures can affect the long-term outcome of those procedures. Especially, repairs and replacements performed on atrioventricular valves are likely to exert direct impact on intra-ventricular flow pattern...
April 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29416572/etiology-of-cesarean-uterine-scar-defect-niche-detailed-critical-analysis-of-hypotheses-and-prevention-strategies-and-peritoneal-closure-debate
#7
REVIEW
Shashikant L Sholapurkar
There is an increasing incidence of cesarean scar (CS) defect/niche and its sequelae, probably not entirely explained by better diagnosis or rising cesarean rate. Discussion of possible etiological factors has received scant attention but would be important to formulate preventive strategies. Meaningful informative studies on long-term sequelae of cesarean section are very difficult and none are available for causation of CS defect. Hence, it is crucial to identify key areas in etiology of CS defect for focused research...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29351725/daylight-mediated-photodynamic-therapy-with-methyl-aminolevulinate-in-actinic-keratosis-treatment
#8
Shantel D J Demay, Kunal Sharma, Sheetal Sapra, Rahul Sapra, Priya Sapra
BACKGROUND: Research has shown daylight-mediated photodynamic therapy (PDT) for the treatment of actinic keratosis (AK) to be effective, tolerable, and convenient, with excellent patient satisfaction and cosmesis. Although success has been demonstrated in areas with similar latitudes to Switzerland and Scandinavia, this treatment has not been studied in a Canadian population. OBJECTIVES: The purpose of this study is to investigate the effectiveness, safety, and patient satisfaction of daylight-mediated methyl 5-aminolevulinate (MAL)-PDT to make recommendations for its use in Canadian practice...
January 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29343176/on-understanding-the-nature-of-interpersonal-conflict-between-coaches-and-athletes
#9
Svenja Wachsmuth, Sophia Jowett, Chris G Harwood
Conflict is a part of coach-athlete relationships and should be carefully considered as it can have effects on the quality of coaching and the level of performance. Despite its practical relevance, there is a dearth of research around coach-athlete conflict. Therefore, the current study aimed to explore the characteristics and topics of conflict, as well as coaches and athletes' emotional, cognitive and behavioural experiences during conflict. A total of 22 independent coaches and athletes participated in semi-structured interviews evolving around the nature of interpersonal conflict...
January 18, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29221498/influence-of-community-based-education-on-undergraduate-health-professions-students-decision-to-work-in-underserved-areas-in-uganda
#10
Samuel Kizito, Rhona Baingana, Kintu Mugagga, Peter Akera, Nelson K Sewankambo
BACKGROUND: Uganda is beset by a shortage of health workers and the few available are mal-distributed. Providing rural exposure through community-based education could positively influence students' perspectives towards work in rural areas. We aimed to assess the impact of Community-Based Education and Research (COBERS) on health professions students' attitudes towards working in rural areas. This was a before-and-after study among 525 students of 4 medical universities in Uganda. Data was collected using self-administered paper-based questionnaires...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29188345/imaging-in-syndesmotic-injury-a-systematic-literature-review
#11
Nicola Krähenbühl, Maxwell W Weinberg, Nathan P Davidson, Megan K Mills, Beat Hintermann, Charles L Saltzman, Alexej Barg
OBJECTIVES: To give a systematic overview of current diagnostic imaging options for assessment of the distal tibio-fibular syndesmosis. MATERIALS AND METHODS: A systematic literature search across the following sources was performed: PubMed, ScienceDirect, Google Scholar, and SpringerLink. Forty-two articles were included and subdivided into three groups: group one consists of studies using conventional radiographs (22 articles), group two includes studies using computed tomography (CT) scans (15 articles), and group three comprises studies using magnet resonance imaging (MRI, 9 articles)...
November 30, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29184296/effects-of-mental-practice-combined-with-electromyogram-triggered-electrical-stimulation-for-upper-extremity-function-in-stroke-patients
#12
Ji-Su Park, Jong-Bae Choi, Duk-Hyun An, Moon-Young Chang
[Purpose] To investigate the effect of mental practice combined with electromyogram-triggered electrical stimulation (MP-EMG ES) on the upper extremity of stroke patients. [Subjects and Methods] Participants were randomly assigned to experimental group or control group. The experimental group received MP-EMG ES plus conventional rehabilitation therapy for 5 days per week for 4 weeks. The control group received only conventional rehabilitation therapy. Outcome measure included the Fugl-Meyer Assessment (FMA) and Motor Activity Log (MAL)...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29136306/patient-and-physician-satisfaction-in-an-observational-study-with-methyl-aminolevulinate-daylight-photodynamic-therapy-in-the-treatment-of-multiple-actinic-keratoses-of-the-face-and-scalp-in-six-european-countries
#13
M C Fargnoli, S H Ibbotson, R E Hunger, G Rostain, M T W Gaastra, L Eibenschutz, C Cantisani, A W Venema, S Medina, N Kerrouche, B Pérez-Garcia
BACKGROUND: Guidelines recommend treating actinic keratoses (AKs) as they are recognized as precursors of invasive squamous cell carcinoma. OBJECTIVE: The objective of this study was to collect real-world clinical data on the use of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) for the treatment of face and scalp AK in Europe. METHODS: A prospective, multicenter, non-interventional study was conducted in six European countries in patients receiving a single treatment of MAL DL-PDT for face and/or scalp AK...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29106837/evaluation-of-industrial-compensation-to-cardiologists-in-2015
#14
MULTICENTER STUDY
Muhammad Shahzeb Khan, Tariq Jamal Siddiqi, Kaneez Fatima, Haris Riaz, Faisal Khosa, Warren J Manning, Richard Krasuski
The categorization and characterization of pharmaceutical and device manufacturers or group purchasing organization payments to clinicians is an important step toward assessing conflicts of interest and the potential impact of these payments on practice patterns. Payments have not previously been compared among the subspecialties of cardiology. This is a retrospective analysis of the Open Payments database, including all installments and payments made to doctors in the calendar year 2015 by pharmaceutical and device manufacturers or group purchasing organization...
December 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29069076/childhood-stunting-in-relation-to-the-pre-and-postnatal-environment-during-the-first-2-years-of-life-the-mal-ed-longitudinal-birth-cohort-study
#15
(no author information available yet)
BACKGROUND: Stunting is the most prevalent manifestation of childhood malnutrition. To characterize factors that contribute to stunting in resource-poor settings, we studied a priori selected biological and social factors collected longitudinally in a cohort of newborns. METHODS AND FINDINGS: We enrolled 1,868 children across 7 resource-poor settings in Bangladesh, Brazil, India, Nepal, Peru, South Africa, and Tanzania shortly after birth and followed them for 24 months between 2 November 2009 and 28 February 2014...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29037267/tracking-of-infant-and-young-child-feeding-practices-among-9-to-24-month-old-children-in-nepal-the-mal-ed-birth-cohort-study
#16
Marianne S Morseth, Liv Elin Torheim, Mekdes K Gebremariam, Ram K Chandyo, Manjeswori Ulak, Sanjaya K Shrestha, Binob Shrestha, Sigrun Henjum
OBJECTIVE: The present study aimed to assess infant and young child feeding (IYCF) practices and the tracking of dietary diversity score (DDS), intakes of Fe- and vitamin A-rich foods and meal frequency in a peri-urban area in Nepal. Furthermore, to explore whether sociodemographic factors were associated with tracking patterns of these IYCF practices. DESIGN: Longitudinal study. Monthly food intake was measured by 24 h recall. Four time slots were used (9-12, 13-16, 17-20 and 21-24 months)...
February 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/28958169/recommendations-for-infant-feeding-policy-and-programs-in-dzimauli-region-south-africa-results-from-the-mal-ed-birth-cohort
#17
Lindelani Fhumudzani Mushaphi, Tjale Cloupas Mahopo, Cebisa Noxolo Nesamvuni, Brenda Baloyi, Ellen Mashau, Jeniata Richardson, Rebecca Dillingham, Richard Guerrant, Ramya Ambikapathi, Pascal Bessong
BACKGROUND: There is strong evidence that exclusive breastfeeding (EBF) in the first 6 months of life reduces the risk of diseases in infancy and in later life. OBJECTIVE: To understand the maternal reasoning that influences optimum infant feeding practices of caregivers in semirural communities of Limpopo province. METHODS: Nested qualitative study among mothers in an ongoing birth cohort study was conducted; structured and semi-structured interviews were used to collect data...
September 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#18
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28893223/brca2-carriers-with-male-breast-cancer-show-elevated-tumour-methylation
#19
Siddhartha Deb, Kylie L Gorringe, Jia-Min B Pang, David J Byrne, Elena A Takano, kConFab Investigators, Alexander Dobrovic, Stephen B Fox
BACKGROUND: Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biological and molecular differences likely to impact on tumour behaviour and therefore patient outcome. The aim of this study was to investigate methylation of a panel of commonly methylated breast cancer genes in familial MBCs. METHODS: 60 tumours from 3 BRCA1 and 25 BRCA2 male mutation carriers and 32 males from BRCAX families were assessed for promoter methylation by methylation-sensitive high resolution melting in a panel of 10 genes (RASSF1A, TWIST1, APC, WIF1, MAL, RARβ, CDH1, RUNX3, FOXC1 and GSTP1)...
September 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28782337/diagnosis-management-and-prevention-of-hepatitis-c-in-pakistan-2017
#20
Muhammad Umar, Hamama-Tul-Bushra Khaar, Tayyab Saeed Akhter, Faiza Aslam, Syed Irfan Ahmad, Rai Mohammad Asghar, Mohammad Khurram, Tassawar Hussain, Amjad Salamat, Anwar A Khan, Fazal-E-Hadi, Zahid Mahmood Minhas, Hasnain Ali Shah, Javed Farooqui, Asif Abbas Naqvi, Aftab Mohsin, Waseem-Ud-Din, Sohail Iqbal Bhutta, Sibt Ul Hasnain Syed, Saleem Qureshi, Tashfeen Adam, Moazzam Uddin, Ghias-U-Nabi Tayyab, Najeeb Ul Haq, Atifa Shoaib, Saima Ambreen, Arslan Shahzad, Nadeem Ikram, Gul Nisar, Mohammad Mujeeb Khan, Mohammad Osama
Aims and Objectives: Since the advent of direct acting antiviral agents, there is a revolutionary change in the management of HCV infection. Newer drugs with different mechanism of action are being introduced and are expected to be available in coming few months in Pakistan as well. The main purpose of the guideline is to review and induct the latest research in field of HCV infection in Pakistani perspective so that our healthcare professionals can apply the new recommendations in timely and judicial manner...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
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