keyword
MENU ▼
Read by QxMD icon Read
search

Fetal Alcohol Spectrum Disorder

keyword
https://www.readbyqxmd.com/read/29024604/the-avian-embryo-as-a-model-for-fetal-alcohol-spectrum-disorders
#1
Susan M Smith, George R Flentke
Prenatal alcohol exposure (PAE) remains a leading preventable cause of structural birth defects and permanent neurodevelopmental disability. The chick (Gallus gallus domesticus) is a powerful embryological research model and was possibly the first (Fere, 1895) in which alcohol's teratogenicity was demonstrated. Pharmacologically relevant alcohol exposures in the range of 20-70 mM (20-80 mg/egg) disrupt chick embryo growth, morphogenesis, and behavior, and the resulting phenotypes strongly parallel those of mammalian models...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29023818/commentary-on-montag-et%C3%A2-al-2017-the-importance-of-cbpr-in-fasd-prevention-with-american-indian-communities
#2
Jessica D Hanson, Tess L Weber
Prenatal alcohol consumption is a public health concern due to potential lifelong physical and cognitive effects in offspring, often presenting in the form of fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). FASD is the continuum of lifelong outcomes in those born prenatally exposed to alcohol and includes a diagnosis of fetal alcohol syndrome (FAS), which is diagnosed through facial abnormalities, growth retardation, and delayed brain growth (Hoyme et al., 2016), as well as secondary disabilities such as conduct disorders, mental illness, and psychosocial functioning...
October 10, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29017910/developmental-ethanol-exposure-alters-the-morphology-of-mouse-prefrontal-neurons-in-a-layer-specific-manner
#3
Emma L Louth, Hanna D Luctkar, Kayla A Heney, Craig D C Bailey
Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent on medial prefrontal cortex (mPFC) circuitry. The objective of this study was to determine long-term effects of chronic developmental ethanol exposure on mPFC neuron morphology, in order to better-understand potential neuronal mechanisms underlying cognitive impairments associated with FASD...
October 7, 2017: Brain Research
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#4
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28988969/fetal-alcohol-spectrum-disorders-zebrafish-in-the-analysis-of-the-milder-and-more-prevalent-form-of-the-disease
#5
REVIEW
Diane Seguin, Robert Gerlai
Fetal Alcohol Spectrum Disorders (FASD) represent a large unmet medical need. Exposure of the developing human embryo to alcohol can lead to life-long suffering. Despite the well documented deleterious effects of alcohol on the developing fetus, pregnant women continue to drink alcohol, and FASD remains the leading cause of preventable mental retardation and other behavioral abnormalities. Particularly prevalent are the milder forms of the disease cluster, representing children who do not show obvious physical signs and who may be undiagnosed or misdiagnosed...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28987617/mitigation-of-postnatal-ethanol-induced-neuroinflammation-ameliorates-trace-fear-memory-deficits-in-juvenile-rats
#6
Molly J Goodfellow, Youn Ju Shin, Derick H Lindquist
Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4 to 9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats...
October 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28982294/the-effect-of-prenatal-alcohol-exposure-on-fetal-growth-and-cardiovascular-parameters-in-a-baboon-model-of-pregnancy
#7
Ana M Tobiasz, Jose R Duncan, Zoran Bursac, Ryan D Sullivan, Danielle L Tate, Alex M Dopico, Anna N Bukiya, Giancarlo Mari
Prenatal alcohol exposure often results in an array of fetal developmental abnormalities termed fetal alcohol spectrum disorders (FASDs). Despite the high prevalence of FASDs, the pathophysiology of fetal damage by alcohol remains poorly understood. One of the major obstacles in studying fetal development in response to alcohol exposure is the inability to standardize the amount, pattern of alcohol consumption, and peak blood alcohol levels in pregnant mothers. In the present study, we used Doppler ultrasonography to assess fetal growth and cardiovascular parameters in response to alcohol exposure in pregnant baboons...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28982012/competition-between-ethanol-clearance-and-retinoic-acid-biosynthesis-in-the-induction-of-fetal-alcohol-syndrome
#8
Yehuda Shabtai, Abraham Fainsod
Several models have been proposed to explain the neurodevelopmental syndrome induced by alcohol exposure of human embryos, known as Fetal Alcohol Spectrum Disorder (FASD). One of the proposed models suggests a competition for the enzymes required for retinoic acid biosynthesis. The outcome of such competition is the development under conditions of reduced retinoic acid signaling. Retinoic acid is one of the biologically-active metabolites of vitamin A (retinol) and regulates numerous embryonic and differentiation processes...
October 5, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28977761/understanding-and-managing-sleep-disruption-in-children-with-fasd
#9
Ana Hanlon-Dearman, Maida Lynn Chen, Heather Carmichael Olson
Accumulating evidence has revealed high rates of sleep disruption among children with Fetal Alcohol Spectrum Disorder (FASD). Multiple animal and clinical studies have found a clear association between sleep problems and prenatal alcohol exposure (PAE), and recent research is beginning to characterize the types and extent of sleep disruption in FASD. Nevertheless, sleep disruption in children with FASD often goes unrecognized or is treated without referring to an evidence base. Children's disrupted sleep interferes with parental sleep and increases caregiver burden, which is of particular importance for families raising children with FASD, a group with very high levels of caregiving stress...
October 4, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28977753/the-manitoba-youth-justice-program-empowering-and-supporting-fasd-affected-youth-in-conflict-with-the-law
#10
Sally Elizabeth Longstaffe, Albert Chudley, Mary Kate Harvie, Teresa Brown, Dan Neault, Trevor John Markesteyn
Fetal Alcohol Spectrum Disorder (FASD) describes a constellation of physical, cognitive, neurologic and behavioral impairments resulting from prenatal exposure to alcohol. FASD is recognized as being one of the largest causes of preventable brain injury in children. There had long been concerns that some youth in conflict with the law may be affected with FASD given repetitive patterns of offending and apparent lack of understanding of consequences of their actions. In 2004 funding was received from Justice Canada for a pilot project with a cross departmental steering committee working together to determine a best way of working across systems to provide FASD assessments to these youth...
October 4, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28961168/choline-and-working-memory-training-improve-cognitive-deficits-caused-by-prenatal-exposure-to-ethanol
#11
Jaylyn Waddell, Sandra M Mooney
Prenatal ethanol exposure is associated with deficits in executive function such as working memory, reversal learning and attentional set shifting in humans and animals. These behaviors are dependent on normal structure and function in cholinergic brain regions. Supplementation with choline can improve many behaviors in rodent models of fetal alcohol spectrum disorders and also improves working memory function in normal rats. We tested the hypothesis that supplementation with choline in the postnatal period will improve working memory during adolescence in normal and ethanol-exposed animals, and that working memory engagement during adolescence will transfer to other cognitive domains and have lasting effects on executive function in adulthood...
September 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28948136/fetal-alcohol-spectrum-disorders-a-case-study
#12
Leila Glass, Sarah N Mattson
This grand rounds manuscript reviews important considerations in developing case conceptualizations for individuals with a history of prenatal alcohol exposure. This case study provides an introduction to fetal alcohol spectrum disorders, diagnostic issues, a detailed description of the individual's history, presenting symptoms, neuropsychological test results, and an integrated summary. We describe a 9-year old girl diagnosed with a fetal alcohol spectrum disorder (FASD): Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE)...
June 2017: J Pediatr Neuropsychol
https://www.readbyqxmd.com/read/28944474/altered-neural-oscillations-during-multisensory-integration-in-adolescents-with-fetal-alcohol-spectrum-disorder
#13
Alfredo D Bolaños, Brian A Coffman, Felicha T Candelaria-Cook, Piyadasa Kodituwakku, Julia M Stephen
BACKGROUND: Children with fetal alcohol spectrum disorder (FASD), who were exposed to alcohol in utero, display a broad range of sensory, cognitive, and behavioral deficits, which are broadly theorized to be rooted in altered brain function and structure. Based on the role of neural oscillations in multisensory integration from past studies, we hypothesized that adolescents with FASD would show a decrease in oscillatory power during event-related gamma oscillatory activity (30-100Hz), when compared to typically-developing healthy controls (HC), and that such decrease in oscillatory power would predict behavioral performance...
September 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28930068/risk-for-alcohol-exposed-pregnancies-among-women-at-drinking-venues-in-cape-town-south-africa
#14
Melissa H Watt, Brandon A Knettel, Karmel W Choi, Elizabeth T Knippler, Philip A May, Soraya Seedat
OBJECTIVE: South Africa's Western Cape Province has one of the highest rates of fetal alcohol spectrum disorder globally. Alcohol-serving venues are likely important sites to identify women at high risk of having a child with fetal alcohol spectrum disorder. The goal of this study was to examine the risk for alcohol-exposed pregnancies among women who drink in alcohol-serving venues. METHOD: Cross-sectional surveys were conducted with 200 women of reproductive age at seven drinking venues in a single Cape Town community...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#15
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28915355/thiamin-deficiency-on-fetal-brain-development-with-and-without-prenatal-alcohol-exposure
#16
Olena Kloss, Michael Eskin, Miyoung Suh
Adequate thiamin levels are crucial for optimal health, through maintenance of homeostasis and viability of metabolic enzymes, which require thiamine as a co-factor. Thiamin deficiency occurs during pregnancy when dietary intake is inadequate or excessive alcohol is consumed. Thiamin deficiency leads to brain dysfunction due to its involvement in synthesis of myelin and neurotransmitters (eg. acetylcholine, γ-aminobutyric acid, glutamate), and increases oxidative stress by decreasing the production of reducing agents...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28887224/the-zebrafish-as-a-promising-tool-for-modeling-human-brain-disorders-a-review-based-upon-an-ibns-symposium
#17
REVIEW
Soaleha Shams, Jason Rihel, Jose G Ortiz, Robert Gerlai
The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders...
September 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28882694/embryonic-alcohol-exposure-leading-to-social-avoidance-and-altered-anxiety-responses-in-adult-zebrafish
#18
Suelen Baggio, Ben Hur Mussulini, Diogo Losch de Oliveira, Robert Gerlai, Eduardo Pacheco Rico
Fetal Alcohol Spectrum Disorders (FASD) is a syndrome characterized by neurological and behavioral impairments. A recently discovered hallmark of FASD is impaired social behavior. Avoidance of social interaction typical of FASD may be the result of increased anxiety. Previously, the zebrafish was successfully used to model embryonic alcohol induced social abnormalities. Here, we analyzed both anxiety and social responses using a zebrafish FASD model, in adult fish. We exposed zebrafish embryos to low concentrations of ethanol (0...
September 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28873290/intelligence-and-fetal-alcohol-spectrum-disorders-a-review
#19
Vanessa K de L Ferreira, Marcelo S Cruz
BACKGROUND: Background: The studies on intelligence in individuals with fetal alcohol exposure are conflicting. Some have found a relevant impairment in this population, while others found results that were consistent with the population at large. OBJECTIVES: Describe the results of studies on intelligence in individuals with Fetal Alcohol Spectrum Disorders. METHODS: Indexed articles of the last 10 years were selected for an integrative literature review...
January 8, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28869026/-a-danish-fetal-alcohol-spectrum-disorders-definition
#20
Marcella Broccia, Jennifer Vikre-Jørgensen, Nete Lundager Klokker Rausgaard
The Danish Paediatric Society presents the first Danish definition of fetal alcohol spectrum disorders (FASD) in a new guideline. FASD is an umbrella term for conditions caused by prenatal alcohol exposure. To varying degrees, fetal alcohol damages manifest as physical defects, characteristic facial features and poor growth, as well as behavioural and cognitive disorders. It requires both somatic and psychological evaluation to identify these damages. Early diagnosis and identification of problems are important for prognosis as professional care has a positive preventive effect on comorbidities...
August 7, 2017: Ugeskrift for Laeger
keyword
keyword
23745
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"