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https://www.readbyqxmd.com/read/28539069/real-world-challenges-for-hepatitis-c-virus-medications-a-critical-overview
#1
Imran Shahid, Waleed Hassan AlMalki, Sajida Hassan, Muhammad Hassan Hafeez
From 2010, the landscape of hepatitis C therapeutics has been changed rapidly, and today we are standing at a cusp of a pharmacological revolution where highly effective and interferon (IFN)-free direct acting antivirals (DAAs) are already on the market. Such treatment paradigms attain 90-95% sustained virologic response (SVR; undetectable viral load at week 12 or 24 at the end of therapy) rates in treated individuals compared to 50-70% with treatment completion of dual-therapy-pegylated interferon (PEG-IFN) and ribavirin (RBV)...
May 25, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28532866/the-effects-of-12-weeks-pilates-inspired-exercise-training-on-functional-performance-in-older-women-a-randomized-clinical-trial
#2
Natália Donzeli Vieira, Daniela Testa, Paula Cristine Ruas, Tânia de Fátima Salvini, Aparecida Maria Catai, Ruth Caldeira Melo
BACKGROUND: Recent scientific evidence supports the benefits of Pilates exercises on postural balance and muscle strength of older persons. However, their effects on other aspects of physical fitness, which are also important for independent living in older age, are still unknown. OBJECTIVE: To investigate the effects of a 12-week Pilates-inspired exercise program on the functional performance of community-dwelling older women. METHODS: Forty community-dwelling older women were randomly enrolled in a Pilates-inspired exercise training (2 times/week, 60 min/session) (PG, n = 21, 66...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28506500/autonomic-and-electrocardiographic-findings-in-parkinson-s-disease
#3
Christopher H Gibbons, David K Simon, Meilin Huang, Barbara Tilley, Michael J Aminoff, Jacquelyn L Bainbridge, Matthew Brodsky, Roy Freeman, John Goudreau, Robert W Hamill, Sheng T Luo, Carlos Singer, Aleksandar Videnovic, Ivan Bodis-Wollner, Pei S Wong
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms and signs. Many reports suggest that diminished heart rate variability occurs early, even prior to the cardinal signs of PD. In a longitudinal study of PD, we evaluated whether heart rate variability (HRV) obtained using a 10-second ECG tracing, and the electrocardiographic QT-interval would be associated with PD severity and progression. Subjects were derived from a longitudinal study of 1741 individuals with early, stable PD...
April 14, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28470591/high-intensity-interval-training-in-facioscapulohumeral-muscular-dystrophy-type-1-a-randomized-clinical-trial
#4
Grete Andersen, Karen Heje, Astrid Emile Buch, John Vissing
Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 × 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7)...
May 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28466851/parental-body-mass-index-and-its-association-with-body-composition-physical-fitness-and-lifestyle-factors-in-their-4-year-old-children-results-from-the-ministop-trial
#5
C Cadenas-Sanchez, P Henriksson, H Henriksson, C Delisle Nyström, J Pomeroy, J R Ruiz, F B Ortega, M Löf
BACKGROUND/OBJECTIVES: To examine the association between parental body mass index (BMI) and their offspring's body composition, physical fitness and lifestyle factors (that is, sedentary time, physical activity and diet). SUBJECTS/METHODS: A total of 307 preschoolers (4.5±0.1 years) and their parents (fathers: 38.1±5.1 years and mothers: 35.6±4.2 years) participated in this study. Parental BMI was calculated using self-reported weight and height. Preschoolers body composition was assessed using: BMI, fat mass percentage, fat mass index, fat-free mass index (measured via air-displacement plethysmography) and waist circumference...
May 3, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28420258/lace-up-for-healthy-feet-the-impact-of-shoe-closure-on-plantar-stress-response
#6
Hadi Rahemi, David G Armstrong, Ana Enriquez, Joshua Owl, Talal K Talal, Bijan Najafi
OBJECTIVE: This study examined the impact of shoe closure on plantar thermal stress response (TSR), which is known to be a surrogate of shear stress and skin perfusion. It is aimed to explore potential impact of shoe closure on increasing risk factors associated with plantar ulcers in people with diabetic peripheral neuropathy (DPN). METHODS: Fifteen eligible subjects were enrolled. The left foot was used as a reference and fitted to a self-adjusted and habitual lace-tightening method by each subject...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28160388/cardiovascular-autonomic-dysfunction-in-ehlers-danlos-syndrome-hypermobile-type
#7
Alan Hakim, Chris O'Callaghan, Inge De Wandele, Lauren Stiles, Alan Pocinki, Peter Rowe
Autonomic dysfunction contributes to health-related impairment of quality of life in the hypermobile type of Ehlers-Danlos syndrome (hEDS). Typical signs and symptoms include tachycardia, hypotension, gastrointestinal dysmotility, and disturbed bladder function and sweating regulation. Cardiovascular autonomic dysfunction may present as Orthostatic Intolerance, Orthostatic Hypotension, Postural Orthostatic Tachycardia Syndrome, or Neurally Mediated Hypotension. The incidence, prevalence, and natural history of these conditions remain unquantified, but observations from specialist clinics suggest they are frequently seen in hEDS...
February 4, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28129779/targeting-functional-fitness-hearing-and-health-related-quality-of-life-in-older-adults-with-hearing-loss-walk-talk-n-listen-study-protocol-for-a-pilot-randomized-controlled-trial
#8
Justin Lambert, Rouzbeh Ghadry-Tavi, Kate Knuff, Marc Jutras, Jodi Siever, Paul Mick, Carolyn Roque, Gareth Jones, Jonathan Little, Harry Miller, Colin Van Bergen, Donna Kurtz, Mary Ann Murphy, Charlotte Ann Jones
BACKGROUND: Hearing loss (HL) is a disability associated with poorer health-related quality of life including an increased risk for loneliness, isolation, functional fitness declines, falls, hospitalization and premature mortality. The purpose of this pilot trial is to determine the feasibility and acceptability of a novel intervention to reduce loneliness, improve functional fitness, social connectedness, hearing and health-related quality of life in older adults with HL. METHODS: This 10-week, single-blind, pilot randomized control trial (RCT) will include a convenience sample of ambulatory adults aged 65 years or older with self-reported HL...
January 28, 2017: Trials
https://www.readbyqxmd.com/read/28117498/factors-that-explain-the-cancer-related-insomnia
#9
Noelia Galiano-Castillo, Manuel Arroyo-Morales, Angélica Ariza-Garcia, Carolina Fernández-Lao, Andrés J Fernández-Fernández, Irene Cantarero-Villanueva
A better understanding of cancer related insomnia and its relationship with other associated factors is necessary to improve its management. To clarify the relationship between insomnia and treatment related variables, sociodemographic data, health related fitness, pain, anxiety, and depression in breast cancer patients. One hundred twenty-three patients participated in this cross-sectional study. As a primary variable was insomnia using The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 version...
January 24, 2017: Breast Journal
https://www.readbyqxmd.com/read/28103811/study-protocol-effect-of-playful-training-on-functional-abilities-of-older-adults-a-randomized-controlled-trial
#10
Jari Due Jessen, Henrik Hautop Lund
BACKGROUND: Loss of functional capabilities due to inactivity is one of the most common reasons for fall accidents, and it has been well established that loss of capabilities can be effectively reduced by physical activity. Pilot studies indicate a possible improvement in functional abilities of community dwelling elderly as a result of short-term playing with an exergame system in the form of interactive modular tiles. Such playful training may be motivational to perform and viewed by the subjects to offer life-fulfilling quality, while providing improvement in physical abilities, e...
January 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28008603/a-pilot-randomized-controlled-trial-of-the-effects-of-chair-yoga-on-pain-and-physical-function-among-community-dwelling-older-adults-with-lower-extremity-osteoarthritis
#11
Juyoung Park, Ruth McCaffrey, David Newman, Patricia Liehr, Joseph G Ouslander
OBJECTIVES: To determine effects of Sit 'N' Fit Chair Yoga, compared to a Health Education program (HEP), on pain and physical function in older adults with lower extremity osteoarthritis (OA) who could not participate in standing exercise. DESIGN: Two-arm randomized controlled trial. SETTING: One HUD senior housing facility and one day senior center in south Florida. PARTICIPANTS: Community-dwelling older adults (N = 131) were randomly assigned to chair yoga (n = 66) or HEP (n = 65)...
March 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27991604/a-pilot-randomized-controlled-trial-of-a-wall-climbing-intervention-for-gynecologic-cancer-survivors
#12
Jennifer J Crawford, Jeff K Vallance, Nicholas L Holt, Gordon J Bell, Helen Steed, Kerry S Courneya
PURPOSE/OBJECTIVES: To examine the feasibility and preliminary efficacy of an eight-week supervised climbing intervention for gynecologic cancer survivors (GCSs).
. DESIGN: A pilot randomized, controlled trial.
. SETTING: The Wilson Climbing Center in Edmonton, Alberta, Canada.
. SAMPLE: 35 GCSs who had completed cancer therapy.
. METHODS: GCSs were randomized to an eight-week (16 session) supervised wall climbing intervention (WCI) (n = 24) or usual care (UC) (n = 11)...
January 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/27927218/efficacy-of-interventions-that-use-apps-to-improve-diet-physical-activity-and-sedentary-behaviour-a-systematic-review
#13
REVIEW
Stephanie Schoeppe, Stephanie Alley, Wendy Van Lippevelde, Nicola A Bray, Susan L Williams, Mitch J Duncan, Corneel Vandelanotte
BACKGROUND: Health and fitness applications (apps) have gained popularity in interventions to improve diet, physical activity and sedentary behaviours but their efficacy is unclear. This systematic review examined the efficacy of interventions that use apps to improve diet, physical activity and sedentary behaviour in children and adults. METHODS: Systematic literature searches were conducted in five databases to identify papers published between 2006 and 2016. Studies were included if they used a smartphone app in an intervention to improve diet, physical activity and/or sedentary behaviour for prevention...
December 7, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27918772/energy-based-facial-rejuvenation-advances-in-diagnosis-and-treatment
#14
Christopher J Britt, Benjamin Marcus
Importance: The market for nonsurgical, energy-based facial rejuvenation techniques has increased exponentially since lasers were first used for skin rejuvenation in 1983. Advances in this area have led to a wide range of products that require the modern facial plastic surgeon to have a large repertoire of knowledge. Objective: To serve as a guide for current trends in the development of technology, applications, and outcomes of laser and laser-related technology over the past 5 years...
January 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27881152/fitness-and-mobility-training-in-patients-with-intensive-care-unit-acquired-muscle-weakness-fitonicu-study-protocol-for-a-randomised-controlled-trial
#15
Jan Mehrholz, Simone Thomas, Jane H Burridge, André Schmidt, Bettina Scheffler, Ralph Schellin, Stefan Rückriem, Daniel Meißner, Katja Mehrholz, Wolfgang Sauter, Ulf Bodechtel, Bernhard Elsner
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP) are a common complication of critical illness. Both cause intensive-care-unit-acquired (ICU-acquired) muscle weakness (ICUAW) which increases morbidity and delays rehabilitation and recovery of activities of daily living such as walking ability. Focused physical rehabilitation of people with ICUAW is, therefore, of great importance at both an individual and a societal level. A recent systematic Cochrane review found no randomised controlled trials (RCT), and thus no supporting evidence, for physical rehabilitation interventions for people with defined CIP and CIM to improve activities of daily living...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27866841/thai-yoga-improves-physical-function-and-well-being-in-older-adults-a-randomised-controlled-trial
#16
Chaiya Noradechanunt, Anthony Worsley, Herbert Groeller
OBJECTIVES: Compare two 12-week low-intensity exercise regimens on components of physical function and quality of life in community-dwelling healthy yet sedentary adults aged over 60. DESIGN: This study used a randomised, multi-arm, controlled trial design. METHODS: Thirty-nine sedentary participants (29 women), aged 67.7±6.7 years were randomly allocated to either a 12-week Thai Yoga (TY) or Tai Chi (TC) for 90min twice per week, or telephone counselling Control (C)...
May 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27848017/effects-of-a-12-week-short-interval-intermittent-low-intensity-slow-jogging-program-on-skeletal-muscle-fat-infiltration-and-fitness-in-older-adults-randomized-controlled-trial
#17
Masahiro Ikenaga, Yosuke Yamada, Yujiro Kose, Kazuhiro Morimura, Yasuki Higaki, Akira Kiyonaga, Hiroaki Tanaka
PURPOSE: We developed a short-interval, low-intensity, slow-jogging (SJ) program consisting of sets of 1 min of SJ at walking speed and 1 min of walking. We aimed to examine the effects of an easily performed SJ program on skeletal muscle, fat infiltration, and fitness in older adults. METHODS: A total of 81 community-dwelling, independent, older adults (70.8 ± 4.0 years) were randomly assigned to the SJ or control group. The SJ group participants were encouraged to perform 90 min of SJ at their anaerobic threshold (AT) intensity and 90 min of walking intermittently per week...
November 15, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27807532/effects-of-therapeutic-tai-chi-on-functional-fitness-and-activities-of-daily-living-in-patients-with-parkinson-disease
#18
Hye-Jung Choi
The purpose of the study is to investigate the effects of therapeutic Tai chi (TTC) on the functional fitness status and activities of daily living (ADL) of patients with Parkinson disease (PD). The participants were clinically stable PDs in Hoehn and Yahr stage 1-2. These patients were randomly assigned to either the TTC group (n=11) or the control (CON) group (n=9). The TTC exercised at the clinic 2 times a week and performed home-based activity 1 time per week for 12 weeks. All the PDs were evaluated for functional fitness test and ADL screen before and after the 12-week trial...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27297443/positive-effects-on-bone-mineralisation-and-muscular-fitness-after-10%C3%A2-months-of-intense-school-based-physical-training-for-children-aged-8-10%C3%A2-years-the-fit-first-randomised-controlled-trial
#19
Malte Nejst Larsen, Claus Malta Nielsen, Eva Wulff Helge, Mads Madsen, Vibeke Manniche, Lone Hansen, Peter Riis Hansen, Jens Bangsbo, Peter Krustrup
OBJECTIVES: We investigated whether musculoskeletal fitness of school children aged 8-10 years was affected by frequent intense PE sessions. DESIGN AND PARTICIPANTS: 295 Danish school children aged 8-10 years were cluster randomised to a small-sided ball game group (SSG) (n=96, four schools, five classes), a circuit strength training group (CST) (n=83, four schools, four classes) or a control group (CON, n=116, two schools, five classes). INTERVENTION: SSG or CST was performed 3×40 min/week over 10 months...
June 13, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27239405/patient-centred-physical-therapy-is-cost-effective-in-increasing-physical-activity-and-reducing-frailty-in-older-adults-with-mobility-problems-a-randomized-controlled-trial-with-6%C3%A2-months-follow-up
#20
Nienke M de Vries, J Bart Staal, Philip J van der Wees, Eddy M M Adang, Reinier Akkermans, Marcel G M Olde Rikkert, Maria W G Nijhuis-van der Sanden
BACKGROUND: Despite the well-known health benefits of physical activity, it is a great challenge to stay physically active for frail-older adults with mobility limitations. The aim of this study was to test the (cost-) effectiveness of a patient-centred physical therapy strategy (Coach2Move) in which individualized treatment (motivational interviewing, physical examination, individualized goal setting, coaching and advice on self management, and physical training) is combined to increase physical activity level and physical fitness and, thereby, to decrease the level of frailty...
September 2016: Journal of Cachexia, Sarcopenia and Muscle
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