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Parotid Gland Tumor

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https://www.readbyqxmd.com/read/28332994/predicting-patient-specific-dosimetric-benefits-of-proton-therapy-for-skull-base-tumors-using-a-geometric-knowledge-based-method
#1
David C Hall, Alexei V Trofimov, Brian A Winey, Norbert J Liebsch, Harald Paganetti
PURPOSE: To predict the organ at risk (OAR) dose levels achievable with proton beam therapy (PBT), solely based on the geometric arrangement of the target volume in relation to the OARs. A comparison with an alternative therapy yields a prediction of the patient-specific benefits offered by PBT. This could enable physicians at hospitals without proton capabilities to make a better-informed referral decision or aid patient selection in model-based clinical trials. METHODS AND MATERIALS: Skull-base tumors were chosen to test the method, owing to their geometric complexity and multitude of nearby OARs...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332304/sclerosing-polycystic-adenosis-a-rare-tumor-misdiagnosed-as-retention-cyst-on-fine-needle-aspiration-cytology
#2
Shilpi, Fuzail Ahmad Ansari, Shalini Bahadur, Akshi Katyal, Aastha Narula, Namrata Nargotra, Sompal Singh
Sclerosing polycystic adenosis (SPA) is a rare benign neoplasm of the salivary gland which resembles the fibrocystic disease of the breast clinically as well as morphologically. This entity has varied morphological presentation on fine needle aspiration. Only a few case reports and occasional case series are found in the literature describing its cytology. Here we are presenting a case of SPA in the parotid gland in a 13-year-old male patient who presented with a slow growing infra-auricular mass since one year without any other symptoms...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28330578/necrotizing-sialometaplasia-of-the-parotid-gland-associated-with-facial-nerve-paralysis
#3
P Haen, L Ben Slama, P Goudot, T Schouman
INTRODUCTION: Necrotizing sialometaplasia is a benign inflammatory lesion involving most frequently the minor salivary gland of the hard palate. Involvement of the parotid gland is rare, involvement of the parotid gland associated with facial palsy is exceptional. CASE REPORT: A 56-year-old male patient with Marfan syndrome presented with swelling and inflammation of the left parotid gland associated with progressively complete facial nerve paralysis. CT scan and MRI showed a parotid collection with hyper signal of the nearest tissues associated with erosion of the styloid process...
February 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28326706/-clinical-efficacy-of-the-fine-needle-aspiration-of-the-cell-block-in-the-diagnosis-of-parotid-gland-masses
#4
Chen Hong, Fang Qingquan, Tu Jinhua, Cai Qiaoling, Zhang Suhua
OBJECTIVE: To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses. METHODS: Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326325/a-potential-of-sfasl-in-preventing-gland-injury-in-sjogren-s-syndrome
#5
Jiao Luo, Ying Wang, Bing Yu, Hongyan Qian, Yan He, Guixiu Shi
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL (sFasL). sFasL can be produced by mFasL cleaved by matrix metalloproteinases (MMP) and also reveals a role for binding to Fas which is expressed on cell surface. Although Fas/FasL axis has been implicated in a variety of diseases, its role in Sjogren's syndrome still remains ill defined. In this study, we investigated the potential of sFasL in the pathogenesis of Sjogren's syndrome (SS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28326216/an-unusual-clinical-presentation-of-solitary-fibrous-tumor-in-the-oral-cavity
#6
Everton Freitas de Morais, Deborah Gondim Lambert Moreira, Viviane Alves De Oliveira, Rodrigo Rodrigues Rodrigues, Adriano Rocha Germano, Roseana de Almeida Freitas
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28321773/salivary-duct-carcinoma-an-update-on-morphologic-mimics-and-diagnostic-use-of-androgen-receptor-immunohistochemistry
#7
Aaron M Udager, Simion I Chiosea
More than 15 years ago, seminal studies by Dr. E. Leon Barnes and colleagues transformed our understanding of salivary duct carcinoma (SDC) and, in doing so, paved the way for contemporary diagnostic and therapeutic approaches to this aggressive salivary adenocarcinoma. In particular, attention to the apocrine phenotype of SDC and expression of androgen receptor (AR) by immunohistochemistry has improved the diagnostic accuracy and showed how SDC can be reliably distinguished from its morphologic mimics (i.e...
March 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28299943/the-value-of-combining-conventional-diffusion-weighted-and-dynamic-contrast-enhanced-mr-imaging-for-the-diagnosis-of-parotid-gland-tumors
#8
Xiaofeng Tao, Gongxin Yang, Pingzhong Wang, Yingwei Wu, Wenjing Zhu, Huimin Shi, Xin Gong, Weiqing Gao, Qiang Yu
OBJECTIVE: The aim of this study was to determine the value of combining conventional MRI, diffusion-weighted (DWI) and dynamic contrast enhanced MRI (DCE-MRI) in diagnosing solid neoplasms in the parotid gland. METHODS: A total of 148 subjects (101 with benign and 47 with malignant tumors) were evaluated with conventional MRI, DWI and DCE-MRI prior to surgery and pathologic verification. The items observed with conventional MRI included the shape, capsule and signal intensity of parotid masses...
March 16, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28299278/a-rare-case-of-parotid-gland-lipoma-arising-from-the-deep-lobe-of-the-parotid-gland
#9
Francesco Paparo, Mauro Massarelli, Giorgio Giuliani
Lipomas are the most commonly encountered benign mesenchymal tumors, but their occurrence in the head and neck is rare, even more at the level of the parotid region where they can be found nearby the parotid capsule, inside the capsule, or within the gland. In addition, lipomas involving the deep parotid lobe are extremely unusual. That is why lipomas are not often considered for differential diagnosis of parotid lumps. Concerning diagnostic tools, magnetic resonance imaging (MRI) is nowadays considered as the main imaging examination for parotid lipomas due to a characteristic signal intensity on T1- and T2-weighted images...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28295401/staging-cutaneous-squamous-cell-carcinoma-metastases-to-the-parotid-gland
#10
Lukasz Czerwonka, Robert J De Santis, Gilad Horowitz, Michael Hong, Mario Orsini, Danny Enepekides, David P Goldstein, Joe Dort, Kevin Higgins
OBJECTIVE: The staging of cutaneous squamous cell cancers (cSCC) was revised by the American Joint Committee on Cancer in 2010 to incorporate known prognostic factors and expand the N (node) category. The purpose of this study was to validate this staging system using a North American cohort, and to compare it to the O'Brien P (Parotid) and N staging system. METHODS: An exhaustive collaborative database search was performed for all patients with cSCC metastasis to the parotid gland treated at three major Canadian tertiary referral centers from December 1999 to March 2015...
March 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28292389/salivary-duct-carcinoma-of-the-parotid-gland-report-of-two-cases-in-females
#11
Syed Aslam Shah, Arfa Nawazish, Muhammad Tahir, Syed Muhammad Ali Shah, Mohammad Faheem
Salivary duct carcinoma is a rare tumor, commonly involving parotid gland. It typically affects middle aged to elderly males. The tumor has an aggressive behaviour and is notorious for early metastasis, high rate of local recurrence, and high mortality. Treatment is mainly surgical but other modalities are also used. We are reporting 2 cases in females who had different presentation, course of disease, treatment, and prognosis.
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28280360/arenobufagin-activates-p53-to-trigger-esophageal-squamous-cell-carcinoma-cell-apoptosis-in-vitro-and-in-vivo
#12
Junhong Lv, Shaohuan Lin, Panli Peng, Changqing Cai, Jianming Deng, Mingzhi Wang, Xuejun Li, Rongsheng Lin, Yu Lin, Ailing Fang, Qiling Li
Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little information about the effects and action mechanisms of bufadienolides on ESCC cells. In this study, the in vitro and in vivo anti-ESCC activities of bufadienolides, including bufalin (Bu) and arenobufagin (ArBu), were examined and the underlying molecular mechanisms were elucidated...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28271999/postoperative-radiotherapy-in-salivary-gland-carcinoma-a-single-institution-experience
#13
Öztun Temelli, Ersoy Kekilli, Ahmet Kizilay
BACKGROUND: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. MATERIALS AND METHODS: The medical records of 30 patients with salivary gland tumors operated on and referred to our clinic for adjuvant RT between January 2004 and June 2015 were retrospectively evaluated...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28262005/parotid-or-carotid-misled-by-site
#14
Ruchita Tyagi, Manish Munjal, Pavneet Kaur, Harpreet Kaur, Neena Sood
We present an interesting scenario where a 64 years old male presented with a long standing painless, infra-auricular swelling, which had progressively increased in size. Based on the site, the clinical impression was of a salivary gland lesion and FNAC was performed. The smears were unusually cellular and had necrotic background. The cytological diagnosis was a cystic neoplasm of salivary gland, possibly mucoepidermoid carcinoma. Warthin's tumor was also kept in differential. However, the radiological investigations, which were made available after the FNAC report were conflicting with cytological diagnosis of a malignancy and were characteristic of a carotid body tumor, generally a benign neoplasm...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28255469/differential-diagnosis-of-parotid-lipoma-in-a-breast-ca-patient
#15
Melda Misirlioglu, Yagmur Yilmaz Akyil, Mehmet Zahit Adisen, Alime Okkesim
Lipomas are common benign tumors usually detected on the torso, neck, upper thighs, and upper arms. However, they are rarely found in the parotid gland region. Because of their rarity at this site, they are not often considered in the differential diagnosis of parotid tumors. This report describes a rare case of a lipoma in the superficial lobe of parotid gland. A 71-year-old female patient admitted to our department complaining about swelling and pain in the posterior area of the left mandibular region since one month...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28250301/tumor-induced-osteomalacia-caused-by-a-parotid-tumor
#16
Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Manabu Taguchi, Masaaki Takahashi, Naoya Egami, Shogo Tajima, Masaomi Nangaku, Seiji Fukumoto
A 77-year-old man was suspected of having tumor-induced osteomalacia (TIO) because of hypophosphatemia (1.9 mg/dL) and elevated serum fibroblast growth factor 23 (FGF23) level (186.9 pg/mL). We detected a tumor in his left parotid gland, and the FGF23 level in the left external jugular vein indicated that the tumor overproduced FGF23. After the removal of the tumor, the serum FGF23 level rapidly decreased, and the serum phosphate normalized. This is the first case of TIO caused by a tumor in a parotid gland...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28249655/salivary-gland-pleomorphic-adenoma-in-the-netherlands-a-nationwide-observational-study-of-primary-tumor-incidence-malignant-transformation-recurrence-and-risk-factors-for-recurrence
#17
M H Valstar, M de Ridder, E C van den Broek, M M Stuiver, B A C van Dijk, M L F van Velthuysen, A J M Balm, L E Smeele
INTRODUCTION: Whereas salivary gland pleomorphic adenoma (SGPA) is the most common type of salivary gland tumor, little is known about its epidemiology because national cancer registries do not register this disease. OBJECTIVES: To establish SGPA incidence trends, rates of secondary malignant transformation and recurrence and associated factors in the Netherlands. MATERIALS AND METHODS: Data on incidence, epidemiology, secondary malignant transformation and recurrence were retrieved from the Dutch pathology registry (PALGA) for the years 1992, 1997, 2002, 2007, and 2012...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28246588/intermittent-facial-spasms-as-the-presenting-sign-of-a-recurrent-pleomorphic-adenoma
#18
Rosalie A Machado, Sami P Moubayed, Azita Khorsandi, Juan C Hernandez-Prera, Mark L Urken
The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma arising in a recurrent pleomorphic adenoma of the left parotid gland (i.e., carcinoma ex pleomorphic adenoma) that presented with hemifacial spasms...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28207533/lymphoepithelial-carcinoma-of-the-salivary-glands
#19
Yeun J Kim, Hyun S Hong, Sun H Jeong, Eun H Lee, Min J Jung
RATIONALE: Lymphoepithelial carcinoma (LEC) is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Here, we report 3 cases of primary LEC arising in the major salivary glands, which showed unusual imaging features unlike other malignant tumors. PATIENT CONCERNS: Our first case is a 44-year-old man with LEC in the right parotid gland, the second case is a 71-year-old woman with LEC in the right submandibular gland, and the third case is a 35-year-old woman with LEC in the right parotid gland...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28180194/prospective-evaluation-of-quasistatic-ultrasound-elastography-use-compared-with-baseline-us-for-parotid-gland-lesions-preliminary-results-of-elasticity-contrast-index-eci-evaluation
#20
Vito Cantisani, Emanuele David, Armando De Virgilio, Paul S Sidhu, Hektor Grazhdani, Antonio Greco, Marco De Vincentiis, Alessandro Corsi, Flaminia De Cristofaro, Luca Brunese, Fabrizio Calliada, Alfredo Blandino, Mario Tombolini, Giorgio Ascenti, Roberto Stramare, Marcello Caratozzolo, Ferdinando D'Ambrosio
AIMS: To assess the diagnostic value of elasticity contrast index (ECI) elastography, in comparison with conventional ultrasound for the differentiation of benign and malignant parotid lesions. MATERIAL AND METHODS: Sixty-three consecutive patients with parotid gland tumors, treated surgically at a single tertiary center were enrolled. Ultrasound evaluation consisted of B-mode, color-Doppler and quasistatic ultrasound elastography (USE), conducted with the ECI technique...
January 31, 2017: Medical Ultrasonography
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