keyword
MENU ▼
Read by QxMD icon Read
search

TRPV4

keyword
https://www.readbyqxmd.com/read/29152668/the-role-of-astrocytic-calcium-and-trpv4-channels-in-neurovascular-coupling
#1
Allanah Kenny, Michael J Plank, Tim David
Neuronal activity evokes a localised change in cerebral blood flow in a response known as neurovascular coupling (NVC). Although NVC has been widely studied the exact mechanisms that mediate this response remain unclear; in particular the role of astrocytic calcium is controversial. Mathematical modelling can be a useful tool for investigating the contribution of various signalling pathways towards NVC and for analysing the underlying cellular mechanisms. The lumped parameter model of a neurovascular unit with both potassium and nitric oxide (NO) signalling pathways and comprised of neurons, astrocytes, and vascular cells has been extended to include the glutamate induced astrocytic calcium pathway with epoxyeicosatrienoic acid (EET) signalling and the stretch dependent TRPV4 calcium channel on the astrocytic endfoot...
November 20, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29148820/a-functional-kinase-short-interfering-ribonucleic-acid-screen-using-protease-activated-receptor-2-dependent-opening-of-transient-receptor-potential-vanilloid-4
#2
William G Darby, Megan S Grace, Kaylene J Simpson, Owen L Woodman, Peter McIntyre
Protease-activated receptor 2 (PAR2) is a proinflammatory G-protein coupled receptor (GPCR) that is activated by inflammatory proteases, and its activation initiates signaling pathways that modulate the nonselective cation channel transient receptor potential vanilloid-4 (TRPV4). PAR2-dependent opening of TRPV4 has been attributed to kinase activation, but the identity of the responsible enzymes is unknown. Deciphering the signaling pathways involved in the PAR2-dependent opening of TRPV4 may yield new targets for pain treatment...
November 17, 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29126921/the-role-of-trpv4-in-fibrosis
#3
REVIEW
Lei Zhan, Jun Li
The transient receptor potential vanilloid 4 (TRPV4) is a highly Ca(2+)-permeable non-selective cation channel in TRPV family. Accumulating evidence hints that TRPV4 play a significant role in a wide diversity of pathologic changes. Fibrosis is a kind of chronic disease which was characterized by the formation of excessive accumulation of extracellular matrix (ECM) components in tissues and organs. In recent years, a growing body of studies showed that TRPV4 acted as a crucial regulator in the progression of fibrosis including myocardial fibrosis, cystic fibrosis, pulmonary fibrosis, hepatic fibrosis and pancreatic fibrosis, suggesting TRPV4 may be a potential therapeutic vehicle in fibrotic diseases...
November 7, 2017: Gene
https://www.readbyqxmd.com/read/29109192/turning-dilatation-to-constriction-endothelial-trpv4-transient-receptor-potential-vanilloid-4-matters
#4
EDITORIAL
Zhiming Zhu, Peng Gao, Yu Huang
No abstract text is available yet for this article.
November 6, 2017: Hypertension
https://www.readbyqxmd.com/read/29109190/trpv4-transient-receptor-potential-vanilloid-4-mediates-endothelium-dependent-contractions-in-the-aortae-of-hypertensive-mice
#5
Peng Zhang, Chunyuan Sun, Hongjuan Li, Chunlei Tang, Hao Kan, Zhenyu Yang, Aiqin Mao, Xin Ma
The role of TRPV4 (transient receptor potential vanilloid 4) in regulating vascular contraction in hypertensive mice is poorly established. We tested the hypothesis that TRPV4 regulates endothelium-dependent contractions in aortae from hypertensive mice through the activation of cytosolic cPLA2 (phospholipase A2) and COX2 (cyclooxygenase 2) and identified the possible endothelium-derived contracting factor generated by COX2. Using myography, we demonstrated that GSK1016790A (a TRPV4 agonist) and acetylcholine (ACh) trigger endothelium-dependent contractions in aortae from hypertensive mice, and the contractions were abolished with TRPV4 deletion...
November 6, 2017: Hypertension
https://www.readbyqxmd.com/read/29107647/muscle-protective-effects-of-schisandrae-fructus-extracts-in-old-mice-after-chronic-forced-exercise
#6
Ki-Young Kim, Sae-Kwang Ku, Ki-Won Lee, Chang-Hyun Song, Won G An
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandrae Fructus (SF), the dried fruit of Schisandra chinensis (Turcz.) Baill., is a well-known traditional herb used in Asia for enhancing physical work capacity as well as providing anti-stress and anti-inflammatory effects. Extracts of SF (SFe) have also been reported to increase skeletal muscle mass and inhibit muscle atrophy. AIM OF THE STUDY: We examined whether SFe had muscle-protective effects in old mice after chronic forced exercises, and, if so, relevant mechanisms...
October 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29100528/silica-nanoparticles-inhibit-the-cation-channel-trpv4-in-airway-epithelial-cells
#7
Alicia Sanchez, Julio L Alvarez, Kateryna Demydenko, Carole Jung, Yeranddy A Alpizar, Julio Alvarez-Collazo, Stevan M Cokic, Miguel A Valverde, Peter H Hoet, Karel Talavera
BACKGROUND: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure levels experienced by the general population and the ability of SiNPs to penetrate cells and tissues have raised concerns about possible toxic effects of this material. Although SiNPs are known to affect the function of the airway epithelium, the molecular targets of these particles remain largely unknown...
November 3, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29097199/trpv4-is-involved-in-irisin-induced-endothelium-dependent-vasodilation
#8
Li Ye, Mengnan Xu, Min Hu, Hai Zhang, Xianming Tan, Qing Li, Bing Shen, Junhao Huang
Irisin, an exercise-induced myokine, induces conversion of white into brown adipocytes, promoting mitochondrial biogenesis and energy expenditure. Irisin has a vascular protective effect on endothelial function in animals, including humans. Defects in irisin signaling pathways result in endothelial dysfunction in obesity and diabetes. However, the mechanisms underlying the effects of irisin on endothelial function have not been elucidated. Transient receptor potential vanilloid subtype 4 (TRPV4) channels are one of the most important Ca(2+)-permeable cation channels in vascular endothelial cells...
October 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29090425/endogenous-trpv4-expression-of-a-hybrid-neuronal-cell-line-n18d3-and-its-utilization-to-find-a-novel-synthetic-ligand
#9
Sungjae Yoo, Seung-In Choi, Seul Lee, Jiho Song, Chungmi Yang, Sangsu Bang, Seung Up Kim, Kyung Hoon Min, Sun Wook Hwang
Primary sensory afferent neurons detect environmental and painful stimuli at their peripheral termini. A group of transient receptor potential ion channels (TRPs) are expressed in these neurons and constitute sensor molecules for the stimuli such as thermal, mechanical, and chemical insults. We examined whether a mouse sensory neuronal line, N18D3, shows the sensory TRP expressions and their functionality. In Ca(2+) imaging and electrophysiology with these cells, putative TRPV4-mediated responses were observed...
October 31, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29079544/megalencephalic-leukoencephalopathy-with-subcortical-cysts-a-personal-biochemical-retrospective
#10
REVIEW
Raúl Estévez, Xabier Elorza-Vidal, Héctor Gaitán-Peñas, Carla Pérez-Rius, Mercedes Armand-Ugón, Marta Alonso-Gardón, Efren Xicoy-Espaulella, Sònia Sirisi, Tanit Arnedo, Xavier Capdevila-Nortes, Tania López-Hernández, Marisol Montolio, Anna Duarri, Oscar Teijido, Alejandro Barrallo-Gimeno, Manuel Palacín, Virginia Nunes
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy characterized by dysfunction of the role of glial cells in controlling brain fluid and ion homeostasis. Patients affected by MLC present macrocephaly, cysts and white matter vacuolation, which lead to motor and cognitive impairments. To date, there is no treatment for MLC, only supportive care. MLC is caused by mutations in the MLC1 and GLIALCAM genes. MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family...
October 25, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29057902/trpv4-activation-triggers-protective-responses-to-bacterial-lipopolysaccharides-in-airway-epithelial-cells
#11
Yeranddy A Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A J Vanoirbeek, Victor M Meseguer, Thomas Voets, Julio L Alvarez, Peter W Hellings, Peter H M Hoet, Benoit Nemery, Miguel A Valverde, Karel Talavera
Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune pathway. Here we show that airway epithelial cells display an increase in intracellular Ca(2+) concentration within seconds of LPS application. This response occurs in a TLR4-independent manner, via activation of the transient receptor potential vanilloid 4 cation channel (TRPV4). We found that TRPV4 mediates immediate LPS-induced increases in ciliary beat frequency and the production of bactericidal nitric oxide...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29053877/trpv4-regulates-vascular-endothelial-permeability-during-colonic-inflammation-in-dextran-sulphate-sodium-induced-murine-colitis
#12
Kenjiro Matsumoto, Riho Yamaba, Ken Inoue, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Makoto Tominaga, Shinichi Kato
BACKGROUND AND PURPOSE: The transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel involved in physical sensing in various tissue types. The present study aimed to elucidate the function and expression of TRPV4 in colonic vascular endothelial cells during dextran sulphate sodium (DSS)-induced colitis. EXPERIMENTAL APPROACH: The role of TRPV4 in the progression of colonic inflammation was examined in the 2 % DSS-induced murine colitis model using immunohistochemical analysis, western blotting, and Evans blue dye extrusion assay...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29038158/activation-of-human-transient-receptor-potential-melastatin-8-trpm8-by-calcium-rich-particulate-materials-and-effects-on-human-lung-cells
#13
John G Lamb, Erin G Romero, Zhenyu Lu, Seychelle K Marcus, Hannah C Peterson, John M Veranth, Cassandra E Deering-Rice, Christopher A Reilly
To better understand how adverse health effects are caused by particulate materials, and to develop preventative measures, it is important to identify the properties of particles and proteins that link exposure with specific biological outcomes. Coal fly ash (CFA) is a by-product of coal combustion that can affect human health. Here we show that human transient receptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-Δ801) are activated by CFA and calcium-rich nanoparticles and/or soluble salts within CFA...
October 16, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29037241/the-potassium-channel-kca3-1-constitutes-a-pharmacological-target-for-astrogliosis-associated-with-ischemia-stroke
#14
Mengni Yi, Tianjiao Wei, Yanxia Wang, Qin Lu, Gaoxian Chen, Xiaoling Gao, Herbert M Geller, Hongzhuan Chen, Zhihua Yu
BACKGROUND: Reactive astrogliosis is one of the significantly pathological features in ischemic stroke accompanied with changes in gene expression, morphology, and proliferation. KCa3.1 was involved in TGF-β-induced astrogliosis in vitro and also contributed to astrogliosis-mediated neuroinflammation in neurodegeneration disease. METHODS: Wild type mice and KCa3.1(-/-) mice were subjected to permanent middle cerebral artery occlusion (pMCAO) to evaluate the infarct areas by 2,3,5-triphenyltetrazolium hydrochloride staining and neurological deficit...
October 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29026201/dual-contribution-of-trpv4-antagonism-in-the-regulatory-effect-of-vasoinhibins-on-blood-retinal-barrier-permeability-diabetic-milieu-makes-a-difference
#15
David Arredondo Zamarripa, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Fernando López-Casillas, Wolfgang Liedtke, Carmen Clapp, Stéphanie Thébault
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate the expression of some transient receptor potential (TRP) family members, yet their role in regulating the TRP vanilloid subtype 4 (TRPV4) remains unknown. TRPV4 is a calcium-permeable channel involved in barrier permeability, which blockade has been shown to prevent and resolve pulmonary edema...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29018170/temperature-activated-ion-channels-in-neural-crest-cells-confer-maternal-fever-associated-birth-defects
#16
Mary R Hutson, Anna L Keyte, Miriam Hernández-Morales, Eric Gibbs, Zachary A Kupchinsky, Ioannis Argyridis, Kyle N Erwin, Kelly Pegram, Margaret Kneifel, Paul B Rosenberg, Pavle Matak, Luke Xie, Jörg Grandl, Erica E Davis, Nicholas Katsanis, Chunlei Liu, Eric J Benner
Birth defects of the heart and face are common, and most have no known genetic cause, suggesting a role for environmental factors. Maternal fever during the first trimester is an environmental risk factor linked to these defects. Neural crest cells are precursor populations essential to the development of both at-risk tissues. We report that two heat-activated transient receptor potential (TRP) ion channels, TRPV1 and TRPV4, were present in neural crest cells during critical windows of heart and face development...
October 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28994159/calcium-and-electrical-dynamics-in-lymphatic-endothelium
#17
Erik J Behringer, Joshua P Scallan, Mohammad Jafarnejad, Jorge A Castorena-Gonzalez, Scott D Zawieja, James E Moore, Michael J Davis, Steven S Segal
Subsequent to a rise in intracellular Ca(2+) ([Ca(2+) ]i ), hyperpolarization of the endothelium coordinates vascular smooth muscle relaxation along resistance arteries during blood flow control. In the lymphatic vasculature, collecting vessels generate rapid contractions coordinated along lymphangions to propel lymph, but the underlying signalling pathways are unknown. We tested the hypothesis that lymphatic endothelial cells (LECs) exhibit Ca(2+) and electrical signalling properties that facilitate lymph propulsion...
October 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28980722/calcium-signaling-of-in-situ-chondrocytes-in-articular-cartilage-under-compressive-loading-roles-of-calcium-sources-and-cell-membrane-ion-channels
#18
Mengxi Lv, Yilu Zhou, Xingyu Chen, Lin Han, Liyun Wang, X Lucas Lu
Mechanical loading on articular cartilage can induce many physical and chemical stimuli on chondrocytes residing in the extracellular matrix (ECM). Intracellular calcium ([Ca(2+) ]i ) signaling is among the earliest responses of chondrocytes to physical stimuli, but the [Ca(2+) ]i signaling of in situ chondrocytes in loaded cartilage is not fully understood due to the technical challenges in [Ca(2+) ]i imaging of chondrocytes in a deforming ECM. This study developed a novel bi-directional microscopy loading device that enables the record of transient [Ca(2+) ]i responses of in situ chondrocytes in loaded cartilage...
October 5, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28978477/omega-3-fatty-acids-modulate-trpv4-function-through-plasma-membrane-remodeling
#19
Rebeca Caires, Francisco J Sierra-Valdez, Jonathan R M Millet, Joshua D Herwig, Esra Roan, Valeria Vásquez, Julio F Cordero-Morales
Dietary consumption of ω-3 polyunsaturated fatty acids (PUFAs), present in fish oils, is known to improve the vascular response, but their molecular targets remain largely unknown. Activation of the TRPV4 channel has been implicated in endothelium-dependent vasorelaxation. Here, we studied the contribution of ω-3 PUFAs to TRPV4 function by precisely manipulating the fatty acid content in Caenorhabditis elegans. By genetically depriving the worms of PUFAs, we determined that the metabolism of ω-3 fatty acids is required for TRPV4 activity...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28970794/functional-cooperation-between-kca3-1-and-trpv4-channels-in-bronchial-smooth-muscle-cell-proliferation-associated-with-chronic-asthma
#20
Zhihua Yu, Yanxia Wang, Lu Qin, Hongzhuan Chen
Airway smooth muscle cells (SMC) proliferation contributes to the airways remodeling and irreversible airway obstruction during severe asthma, but the mechanisms of airway SMC proliferation are poorly understood. Intracellular Ca(2)(+) levels play an important role in regulating cell proliferation. We have previously reported KCa3.1 channels regulated human bronchial smooth muscle (HBSM) cells proliferation via the Ca(2+) influx as a consequence of membrane hyperpolarization. However, the role of potassium channels KCa3...
2017: Frontiers in Pharmacology
keyword
keyword
23732
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"