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https://www.readbyqxmd.com/read/29776788/next-generation-sequencing-identifies-trpv4-related-skeletal-dysplasia-in-a-boy-with-progressive-bowlegs
#1
Rai-Hseng Hsu, Wuh-Liang Hwu, Ming Chen, I-Fang Chung, Steven Shinn-Forng Peng, Chen-Yang Chen, Wei-Chung Cheng, Yin-Hsiu Chien, Ni-Chung Lee
No abstract text is available yet for this article.
April 13, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29770609/whole-exome-sequencing-for-variant-discovery-in-blepharospasm
#2
Jun Tian, Satya R Vemula, Jianfeng Xiao, Enza Maria Valente, Giovanni Defazio, Simona Petrucci, Angelo Fabio Gigante, Monika Rudzińska-Bar, Zbigniew K Wszolek, Kathleen D Kennelly, Ryan J Uitti, Jay A van Gerpen, Peter Hedera, Elizabeth J Trimble, Mark S LeDoux
BACKGROUND: Blepharospasm (BSP) is a type of focal dystonia characterized by involuntary orbicularis oculi spasms that are usually bilateral, synchronous, and symmetrical. Despite strong evidence for genetic contributions to BSP, progress in the field has been constrained by small cohorts, incomplete penetrance, and late age of onset. Although several genetic etiologies for dystonia have been identified through whole-exome sequencing (WES), none of these are characteristically associated with BSP as a singular or predominant manifestation...
May 16, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29765419/low-magnitude-of-compression-enhances-biosynthesis-of-mesenchymal-stem-cells-towards-nucleus-pulposus-cells-via-the-trpv4-dependent-pathway
#3
Yibo Gan, Bing Tu, Pei Li, Jixing Ye, Chen Zhao, Lei Luo, Chengmin Zhang, Zetong Zhang, Linyong Zhu, Qiang Zhou
Mesenchymal stem cell- (MSC-) based therapy is regarded as a promising tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to promote the biosynthesis of MSC to meet the requirement of NP regeneration. The purpose of this study was to optimize the compressive magnitude to enhance the extracellular matrix (ECM) deposition towards discogenesis of MSCs. Thus, we constructed a 3D culture model for MSCs to bear different magnitudes of compression for 7 days (5%, 10%, and 20% at the frequency of 1...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29737240/mtros-induced-trpv4-activation-in-traumatic-brain-injury
#4
Karthik Suresh
In a recent article in J. Neurotrauma, Szarka et al report a novel role for mtROS in activating TRPV4 and promoting myogenic constriction in TBI. We discuss the implications of this article and the exciting body of emerging literature surrounding redox activation of TRPV4.
May 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29733975/role-of-trpv1-and-trpv4-in-surgical-incision-induced-tissue-swelling-and-fos-like-immunoreactivity-in-the-central-nervous-system-of-mice
#5
Yasuhito Motojima, Haruki Nishimura, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentaro Tanaka, Reiko Saito, Mitsuhiro Yoshimura, Takashi Maruyama, Takanori Matsuura, Hitoshi Suzuki, Makoto Kawasaki, Hideo Ohnishi, Akinori Sakai, Yoichi Ueta
Pain management remains a major concern regarding the treatment of postoperative patients. Transient receptor potential (TRP) channels are considered to be new therapeutic targets for pain control. We investigated whether the genes Trpv1 and Trpv4 are involved in hind paw swelling caused after surgical incision in mice or in incision-induced Fos-like immunoreactivity (Fos-LI) levels in the central nervous system. Mice were divided into four groups: wild-type (WT) control, WT incision, Trpv1 knockout (Trpv1-/- ) incision, and Trpv4 knockout (Trpv4-/- ) incision...
May 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29721987/trpv4-does-not-regulate-the-distal-retinal-light-response
#6
Oleg Yarishkin, Tam T T Phuong, Monika Lakk, David Križaj
The transient receptor potential vanilloid isoform 4 (TRPV4) functions as polymodal transducer of swelling, heat, stretch, and lipid metabolites, is widely expressed across sensory tissues, and has been implicated in pressure sensing in vertebrate retinas. Although TRPV4 knockout mice exhibit a variety of mechanosensory, nociceptive, and thermo- and osmoregulatory phenotypes, it is not known whether the transmission of light-induced signals in the eye is affected by the loss of TRPV4. We utilized field potentials, a measure of rod and cone signaling, to determine whether TRPV4 impacts on the generation and/or transmission of the photoreceptor light response and neurotransmission...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29715474/trpv4-inhibition-prevents-paclitaxel-induced-neurotoxicity-in-preclinical-models
#7
Wolfgang Boehmerle, Petra Huehnchen, Sabrina Lin Lin Lee, Christoph Harms, Matthias Endres
Paclitaxel is a cytotoxic drug which frequently causes sensory peripheral neuropathy in patients. Increasing evidence suggests that altered intracellular calcium (Ca2+ ) signals play an important role in the pathogenesis of this condition. In the present study, we examined the interplay between Ca2+ release channels in the endoplasmic reticulum (ER) and Ca2+ permeable channels in the plasma membrane in the context of paclitaxel mediated neurotoxicity. We observed that in small to medium size dorsal root ganglia neurons (DRGN) the inositol-trisphosphate receptor (InsP3 R) type 1 was often concentrated in the periphery of cells, which is in contrast to homogenous ER distribution...
April 30, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29713744/skin-neurogenic-inflammation
#8
REVIEW
Jae Eun Choi, Anna Di Nardo
The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than others in the generation of itch. The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation...
April 30, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29707744/trpv4-mediated-anti-nociceptive-effect-of-suberanilohydroxamic-acid-on-mechanical-pain
#9
Geunyeol Choi, Tae-Jin Yang, Sungjae Yoo, Seung-In Choi, Ji Yeon Lim, Pyung Sun Cho, Sun Wook Hwang
Biological effects of suberanilohydroxamic acid (SAHA) have mainly been observed in the context of tumor suppression via epigenetic mechanisms, but other potential outcomes from its use have also been proposed in different fields such as pain modulation. Here, we tried to understand whether SAHA modulates specific pain modalities by a non-epigenetic unknown mechanism. From 24 h Complete Freund's Adjuvant (CFA)-inflamed hind paws of mice, mechanical and thermal inflammatory pain indices were collected with or without immediate intraplantar injection of SAHA...
April 29, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29701904/trpv4-activates-cytosolic-phospholipase-a-2-via-ca-2-dependent-pkc-erk1-2-signaling-in-controlling-hypertensive-contraction
#10
Hongjuan Li, Hao Kan, Xiaodong Zhang, Zhenyu Yang, Jian Jin, Peng Zhang, Xin Ma
Activation of TRPV4 (transient receptor potential vanilloid 4) has been reported to result in endothelium-dependent contraction in the aortae of hypertensive mice. This contraction involved increased cPLA2 (cytosolic phospholipase A2 ) activity. The mechanism by which TRPV4 regulates cPLA2 activity to induce contraction in hypertension, however, is unknown. Through measurements of arterial tension and protein level, we showed that high salt diet induced hypertension increases activity of PKC (protein kinase C) and ERK1/2 (extracellular signal-regulated kinase 1/2)...
April 27, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29693628/influence-of-mechanical-unloading-on-articular-chondrocyte-dedifferentiation
#11
Simon L Wuest, Martina Caliò, Timon Wernas, Samuel Tanner, Christina Giger-Lange, Fabienne Wyss, Fabian Ille, Benjamin Gantenbein, Marcel Egli
Due to the limited self-repair capacity of articular cartilage, the surgical restoration of defective cartilage remains a major clinical challenge. The cell-based approach, which is known as autologous chondrocyte transplantation (ACT), has limited success, presumably because the chondrocytes acquire a fibroblast-like phenotype in monolayer culture. This unwanted dedifferentiation process is typically addressed by using three-dimensional scaffolds, pellet culture, and/or the application of exogenous factors...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29689522/differential-effects-of-lipopolysaccharide-on-mouse-sensory-trp-channels
#12
Brett Boonen, Yeranddy A Alpizar, Alicia Sanchez, Alejandro López-Requena, Thomas Voets, Karel Talavera
Acute neurogenic inflammation and pain associated to bacterial infection have been traditionally ascribed to sensitization and activation of sensory nerve afferents secondary to immune cell stimulation. However, we recently showed that lipopolysaccharides (LPS) directly activate the Transient Receptor Potential channels TRPA1 in sensory neurons and TRPV4 in airway epithelial cells. Here we investigated whether LPS activates other sensory TRP channels expressed in sensory neurons. Using intracellular Ca2+ imaging and patch-clamp we determined the effects of LPS on recombinant TRPV1, TRPV2, TRPM3 and TRPM8, heterologously expressed in HEK293T cells...
April 14, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29668377/pulsed-infrared-releases-ca-2-from-the-endoplasmic-reticulum-of-cultured-spiral-ganglion-neurons
#13
John N Barrett, Samantha Rincon, Jayanti Singh, Cristina Matthewman, Julio Pasos, Ellen F Barrett, Suhrud M Rajguru
We investigated the effects of pulsed infrared radiation (IR, 1863 nm) stimulation on cytosolic [Ca2+ ] in inner ear spiral ganglion neurons cultured from day 4 postnatal mice and loaded with a fluorescent Ca2+ indicator (fluo-4, -5F or -5N). IR pulse trains (200 µs, 200-250 Hz, 2-5 s) delivered via an optical fiber coupled to IR source produced a rapid, transient temperature increase of 6-11ºC (above a baseline of 24-30 ºC) and evoked transient increases in both nuclear and cytosolic [Ca2+ ] of 0.20 - 1...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29665111/inhibition-of-transient-receptor-potential-vanilloid-4-decreases-the-expressions-of-caveolin-1-and-caveolin-2-after-focal-cerebral-ischemia-and-reperfusion-in-rats
#14
Hui Xie, Wei-Cheng Lu
This study aimed to investigate the effects of transient receptor potential vanilloid 4 (TRPV4) inhibition on blood-brain barrier (BBB) integrity and the expressions of caveolae structural proteins caveolin-1 and caveolin-2 in rats with focal cerebral ischemia and reperfusion. BBB permeability was assessed by Evans blue extravasation. The mRNA and protein expressions of caveolin-1 and caveolin-2 were determined by RT-PCR, Western blot and immunohistochemistry assays. We found that BBB permeability significantly increased and reaches its peak at 72 h of reperfusion in cerebral ischemia-reperfusion rats and is able to be ameliorated by administration of HC-067047, an antagonist of TRPV4...
April 17, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29664963/trpv4-inhibition-attenuates-stretch-induced-inflammatory-cellular-responses-and-lung-barrier-dysfunction-during-mechanical-ventilation
#15
N Pairet, S Mang, G Fois, M Keck, M Kühnbach, J Gindele, M Frick, P Dietl, D J Lamb
Mechanical ventilation is an important tool for supporting critically ill patients but may also exert pathological forces on lung cells leading to Ventilator-Induced Lung Injury (VILI). We hypothesised that inhibition of the force-sensitive transient receptor potential vanilloid (TRPV4) ion channel may attenuate the negative effects of mechanical ventilation. Mechanical stretch increased intracellular Ca2+ influx and induced release of pro-inflammatory cytokines in lung epithelial cells that was partially blocked by about 30% with the selective TRPV4 inhibitor GSK2193874, but nearly completely blocked with the pan-calcium channel blocker ruthenium red, suggesting the involvement of more than one calcium channel in the response to mechanical stress...
2018: PloS One
https://www.readbyqxmd.com/read/29616344/novel-pharmacological-nonopioid-therapies-in-chronic-pain
#16
REVIEW
Alan David Kaye, Elyse M Cornett, Brendon Hart, Shilpadevi Patil, Andrew Pham, Matthew Spalitta, Kenneth F Mancuso
PURPOSE OF REVIEW: Opioid use and abuse has led to a worldwide opioid epidemic. And while opioids are clinically useful when appropriately indicated, they are associated with a wide range of dangerous side effects and whether they are effective at treating or eliminating chronic pain is controversial. There has long been a need for the development of nonopioid alternative treatments for patients that live in pain, and until recently, only a few effective treatments were available. Today, there are a wide range of nonopioid treatments available including NSAIDs, acetaminophen, corticosteroids, nerve blocks, SSRIs, neurostimulators, and anticonvulsants...
April 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29604963/stim1-and-trpv4-regulate-fluid-flow-induced-calcium-oscillation-at-early-and-late-stages-of-osteoclast-differentiation
#17
Ping Li, Xueyan Bian, Chenglin Liu, Shurong Wang, Mengmeng Guo, Yingjie Tao, Bo Huo
Bone resorption is mainly mediated by osteoclasts (OCs), whose formation and function are regulated by intracellular Ca2+ oscillation. Our previous studies demonstrated that fluid shear stress (FSS) lead to Ca2+ oscillation through mechanosensitive cation-selective channels. However, the specific channels responsible for this FSS-induced Ca2+ oscillation remain unknown. In the present study, we examined the expression of several Ca2+ channels in OCs, including STIM1, ORAI1, TRPV1, TRPV4, TRPV5, and TRPV6, by western blotting and reverse transcription-polymerase chain reaction...
May 2018: Cell Calcium
https://www.readbyqxmd.com/read/29602213/expression-of-the-sox9-foxl2-vasa-and-trpv4-genes-in-the-ovaries-and-testes-of-the-morelet-s-crocodile-crocodylus-moreletii
#18
Adriana Martínez-Juárez, Marco A López-Luna, Tania J Porras-Gómez, Norma Moreno-Mendoza
The Sox9 gene is important for determining sex in vertebrates, as well as for maintaining testis morphology and fertility during adult life. In the same way, Vasa is an important gene for the maintenance of the germinal lineage and has been highly conserved throughout evolution, as it is expressed in germ cells of both vertebrates and invertebrates. In the particular case of crocodiles, the expression of Sox9 during gonadal morphogenesis and in the testes of 3-month-old Alligator mississippiensis has been studied...
March 30, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29601335/mechanosensitive-ion-channels-trpv4-and-p2x7-in-disseminating-cancer-cells
#19
Jacob M Hope, Joshua D Greenlee, Michael R King
Cancer metastasis is the second leading cause of death in the United States. Despite its morbidity, metastasis is an inefficient process that few cells can survive. However, cancer cells can overcome these metastatic barriers via cellular responses to microenvironmental cues, such as through mechanotransduction. This review focuses on the mechanosensitive ion channels TRPV4 and P2X7, and their roles in metastasis, as both channels have been shown to significantly affect tumor cell dissemination. Upon activation, these channels help form tumor neovasculature, promote transendothelial migration, and increase cell motility...
March 2018: Cancer Journal
https://www.readbyqxmd.com/read/29582401/trpv4-a-sensor-for-homeostasis-and-pathological-events-in-the-cns
#20
REVIEW
Hemant Kumar, Soo-Hong Lee, Kyoung-Tae Kim, Xiang Zeng, Inbo Han
Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. TRPV4 is involved in maintaining homeostasis, serves as an osmosensor and thermosensor, can be activated directly by endogenous or exogenous chemical stimuli, and can be activated or sensitized indirectly via intracellular signaling pathways...
March 26, 2018: Molecular Neurobiology
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